Mice homozygous for the pirouette 4 Jackson mutation display bi-directional circling and are completely deaf as early as 5 weeks of age. Consistent with a vestibular defect, they fail to swim at the surface of water, but instead roll underwater and sink before rescue.
The pirouette 4 Jackson mutation arose spontaneously in 1999 in the F5 inbreeding generation of an NZB/BlNJ x NZW/LacJ cross and was backcrossed for 10 generations onto the C57BL/6J background before being maintained by sibling intercross of heterozygous females with homozygous males. In 2010 this strain reached generation N10F9.
|Allele Name||pirouette 4 Jackson|
|Gene Symbol and Name||Grxcr1, glutaredoxin, cysteine rich 1|
|Strain of Origin||(NZB/BlNJ x NZW/LacJ)F5|
|Molecular Note||This allele has a deletion that includes exon 1, but not exons 2, 3, or 4.|