| Allele Name | transgene insertion 14, Gordon Fishell |
| Allele Type | Transgenic (Recombinase-expressing, Inducible) |
| Allele Synonym(s) | Atoh1-cre; Math1-cre; Math1-CreERT2; Tg(Atoh1-cre/ESR1)1Fsh; Tg(HBB-cre)1Fsh |
| Gene Symbol and Name | Tg(Atoh1-cre/Esr1*)14Fsh, transgene insertion 14, Gordon Fishell |
| Gene Synonym(s) | |
| Promoter | Atoh1, atonal bHLH transcription factor 1, mouse, laboratory |
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| Expressed Gene | cre/Esr1, Cre recombinase and estrogen receptor 1 fusion gene, |
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| Site of Expression | tamoxifen-inducible cre activity is observed in neural progenitors of the cerebellar rhombic lip, dorsal hindbrain and spinal cord, as well as in inner-ear primordia (with a limited amount of ectopic expression in the primordium of the hippocampus but not the cortex) |
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| Strain of Origin | FVB/N |
| Chromosome | UN |
| Molecular Note | The transgene was designed with a 1.4 kb mouse Math1 (Atoh1) 3' enhancer (and a beta-globin minimal promoter) sequence upstream of a CreERT2 fusion gene (Cre recombinase fused to a G400V/M543A/L544A triple mutation of the human estrogen receptor ligand binding domain). Tamoxifen-inducible cre activity is observed in neural progenitors of the cerebellar rhombic lip, dorsal hindbrain and spinal cord, as well as in inner-ear primordia (with a limited amount of ectopic expression in the primordium of the hippocampus but not the cortex). |
| Mutations Made By | Rob Machold, The Skirball Institute, NYU Sch. of Med. |
