Homozygous mice have reduced viability, especially on a C57BL/6 background. Approximately 1 out of 4 homozygotes are very small and die before reaching 2 weeks of age. The remaining homozygotes are 20-30% smaller than wildtype and heterozygous littermates; these survive and eventually become similar in size to wildtypes. All homozygotes have a characteristic craniofacial defect that includes a very pointed nose, eyes that are delayed in opening, and a shortened jaw. The alpha transcript of the gene is absent, as determined by brain mRNA and protein assays. Beta transcript RNA is present in heart and brain. 

These A kinase (PRKA) anchor protein 6 (<i>Akap6</i>)-mutant mice may be useful in studying developmental biology and craniofacial defects.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

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