This consomic is valuable in the study of sex determination. The TOrl /+ XYAKR/J offspring, from the cross of B6.Cg-TOrl /+ females with C57BL/6JEi-Chr YAKR/J/EiJ males, are sex reversed, with ovarian tissue development.
The AKR/J Y Chromosome was moved onto C57BL/6JEi through repeated backcrossing. In 2007 sperm were cryopreserved from males at generation N73.
|Allele Name||sex-determining region of Chr Y- AKR/J|
|Allele Synonym(s)||AKR YDOM; YAKR|
|Gene Symbol and Name||Sry, sex determining region of Chr Y|
|Strain of Origin||AKR/J|
|Molecular Note||This allele contains all the information necessary and sufficient to initiate normal testis development but is conditionally dysfunctional on the C57BL/6 background.|