JAX
Mouse Strain Datasheet - 007227
B6.B10ScN-Tlr4lps-del/JthJ
The Tlr4Lps-del spontaneous mutation exhibits a defective response to LPS stimulation and affects Toll signaling pathways involved with inflammation, including susceptibility to various bacterial infections, effects of tissue ischemia (including cerebral and retinal ischemia), myocardial infarction, neurodegeneration, and tumor immune responses.
Read More +Genetic overview
| Genetic Background | Generation |
|---|---|
|
C57BL/6 |
N6+N2F5
|
Tlr4lps-del
| Allele Type | Gene Symbol | Gene Name |
|---|---|---|
| Spontaneous | Tlr4 | toll-like receptor 4 |
Research Applications
- Immunology, Inflammation and Autoimmunity Research
Detailed Description
The stimulation of Toll-like receptor 4 (TLR4) by lipopolysaccharide (LPS) induces the release of proinflammatory cytokines that activate immune responses. The Tlr4Lps-del spontaneous mutation corresponds to a 74723 bp deletion that completely removes the Tlr4 coding sequence. No mRNA or protein is expressed. Homozygous mutants exhibit a defective response to LPS stimulation. The functionally similar Tlr4Lps-d mutation found in C3H/HeJ mice (#000659) is a point mutation that causes an amino acid substitution.
Tlr4 -deficient mice display significantly reduced expression of proinflammatory genes compared to controls 24 h after reperfusion triggered by retinal ischemic injury. These include transcriptional factor p65 (Rela), tumor necrosis factor (Thf), interleukin 6 (Il6), chemokine (C-C motif) ligand 2 (Ccl2), chemokine (C-C motif) ligand 5 (Ccl5), chemokine (C-X-C motif) ligand 10 (Cxcl10), cytochrome b-245, beta polypeptide (Cybb), nitric oxide synthase 2 (Nos2), and intercellular adhesion molecule 1 (Icam1) (Dvoriantchikova et al., 2010).
The effect of TLR4 on tumor progression appears to depend on which cells TLR4 resides and the particular ligand involved. For example, enhanced prostrate tumor progression as a result of TLR4 response to a tumor-derived ligand such as Peroxiredoxin is not seen in the Tlr4 deficient mutant mice (Riddell et al., 2011). Conversely, tumor inhibition seen in wild type mice when B16 melanoma cells were stimulated in vitro with LPS was not seen in mutant mice (Nunez et al., 2012).
TLR4 signaling may also act as innate neuroprotective mechanism through clearance of alpha-synuclein as TLR4 ablation impairs the phagocytic response of microglia to alpha-synuclein and enhances neurodegeneration (Stefanova et al. 2011).
Development
Abnormal response to lipopolysaccharide was observed in the inbred strain C57BL/10ScN in the 1970s. The phenotype was subsequently identified as a mutation in the Tlr4 gene. This strain originated from the C57BL/10ScN colony at NCI Frederick and was transferred to the laboratory of Dr. James Thomas, University of Texas Southwestern Medical Center. The allele was introgressed into C57BL/6 by backcrossing for at least five generations. The strain was donated to The Jackson Laboratory Repository in 2008.
Control Suggestions
Selected References
- Poltorak A; He X; Smirnova I; Liu MY; Huffel CV; Du X; Birdwell D; Alejos E; Silva M; Galanos C; Freudenberg M; Ricciardi-Castagnoli P; Layton B; Beutler B. 1998. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282(5396):2085-8. PubMed: 9851930MGI: J:51522
- Vogel SN; Hansen CT; Rosenstreich DL. 1979. Characterization of a congenitally LPS-resistant, athymic mouse strain. J Immunol 122(2):619-22. PubMed: 368244MGI: J:6086
Tlr4lps-del
Allele Symbol: Tlr4lps-del
| Allele Name | defective lipopolysaccharide response, deletion |
|---|---|
| Allele Type | Spontaneous |
| Allele Synonym(s) | TLR4-KO; TLR4lps-; Tlr4- |
| Gene Symbol and Name | Tlr4, toll-like receptor 4 |
| Gene Synonym(s) | ARMD10; CD284; Lps; Lps; RAS-like, family 2, locus 8; Rasl2-8; Rasl2-8; TLR-4; TOLL; lipopolysaccharide response; lipopolysaccharide response |
| Strain of Origin | C57BL/10ScN |
| Chromosome | 4 |
| General Note | C57BL/10ScN, C57BL/10ScNJ, and C57BL10/ScCr mice carry this allele. |
| Molecular Note | This allele has been characterized by lack of mRNA owing to a deletion of the locus. 74723bp of genomic DNA sequence have been removed, apparently encompasing only the Tlr4 gene. |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Immunology, Inflammation and Autoimmunity Research
- CD Antigens, Antigen Receptors, and Histocompatibility Markers
- Tlr deficiency
- Immunodeficiency
- Tlr deficiency
- Inflammation
- Tlr deficiency
- CD Antigens, Antigen Receptors, and Histocompatibility Markers
Genotype: Tlr4lps-del related
- Immunology, Inflammation and Autoimmunity Research
- CD Antigens, Antigen Receptors, and Histocompatibility Markers
- Tlr deficiency
- Immunodeficiency
- Tlr deficiency
- Inflammation
- Tlr deficiency
- CD Antigens, Antigen Receptors, and Histocompatibility Markers
Mammalian Phenotype Terms by Genotype
The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain
Genotype: Tlr4lps-del/Tlr4lps-del
C57BL/10ScCr
immune system phenotype
- abnormal cytokine secretion
- higher levels of Th1 and Th2 cytokines secreted at 4 weeks after infection with Leishmania major than in controls (MGI Ref ID J:88996)
- abnormal macrophage physiology
- poor activation of macrophage by Leishmania major (MGI Ref ID J:88996)
- increased susceptibility to bacterial infection
behavior/neurological phenotype
- hyporesponsive to tactile stimuli
- attenuated mechanical allodynia after nerve injury (MGI Ref ID J:97819)
- increased thermal nociceptive threshold
- attenuated response to heat (MGI Ref ID J:97819)
nervous system phenotype
- abnormal glial cell physiology
- glial activation after nerve injury reduced (MGI Ref ID J:97819)
cardiovascular system phenotype
- decreased response of heart to induced stress
- exhibit reduced cardiac hypertrophy following pressure overload compared to controls (MGI Ref ID J:106358)
homeostasis/metabolism phenotype
- decreased response of heart to induced stress
- exhibit reduced cardiac hypertrophy following pressure overload compared to controls (MGI Ref ID J:106358)
- decreased susceptibility to injury
integument phenotype
- hyporesponsive to tactile stimuli
- attenuated mechanical allodynia after nerve injury (MGI Ref ID J:97819)
- increased thermal nociceptive threshold
- attenuated response to heat (MGI Ref ID J:97819)
hematopoietic system phenotype
- abnormal macrophage physiology
- poor activation of macrophage by Leishmania major (MGI Ref ID J:88996)
Genotype: Tlr4lps-del/Tlr4lps-del
involves: C57BL/10ScN
immune system phenotype
- abnormal tumor necrosis factor level
- diminished TNF alpha expression after 90 minutes of liver ischemia followed by 6 hours of reperfusion (MGI Ref ID J:114368)
- decreased interleukin-10 secretion
- production is suppressed in response to E coli with or without adenosine (MGI Ref ID J:147023)
- decreased interleukin-6 secretion
- production is suppressed in response to E coli (MGI Ref ID J:147023)
homeostasis/metabolism phenotype
- abnormal circulating enzyme level
- abnormal tumor necrosis factor level
- diminished TNF alpha expression after 90 minutes of liver ischemia followed by 6 hours of reperfusion (MGI Ref ID J:114368)
- decreased circulating alanine transaminase level
- serum levels decreased after 90 minutes of liver ischemia followed by 6 hours of reperfusion (MGI Ref ID J:114368)
nervous system phenotype
- CNS ischemia
- abnormal neuron differentiation
cellular phenotype
Genotype: Tlr4lps-del/Tlr4lps-del
C57BL/10ScN
digestive/alimentary phenotype
- rectal hemorrhage
- rectal bleeding after 7 days of dextran sodium sulfate treatment is reduced relative to controls (MGI Ref ID J:37271)
cardiovascular system phenotype
- rectal hemorrhage
- rectal bleeding after 7 days of dextran sodium sulfate treatment is reduced relative to controls (MGI Ref ID J:37271)
immune system phenotype
- increased spleen weight
- spleen weight elevated with dextran sodium sulfate treatment relative to controls (MGI Ref ID J:37271)
respiratory system phenotype
- abnormal pulmonary alveolar duct morphology
- enlarged air spaces distal to the terminal bronchioles (MGI Ref ID J:114985)
- abnormal pulmonary alveolus morphology
- destruction of normal alveolar structures (MGI Ref ID J:114985)
- enlarged lung
- significantly increased lung volume at 3 months of age in contrast to normal body weights through 12 months (MGI Ref ID J:114985)
skeleton phenotype
- increased bone mass
- larger bones at 20-24 weeks of age (MGI Ref ID J:118467)
- increased bone mineral content
- greater mineral content at 20-24 weeks (MGI Ref ID J:118467)
adipose tissue phenotype
- decreased percent body fat/body weight
- 70% less body fat (MGI Ref ID J:118467)
vision/eye phenotype
- abnormal retinal layer morphology
- (MGI Ref ID J:141070)
- abnormal retinal pigment epithelium morphology
- increased number of proliferating cells in the retinal pigment cell layer at 6 days of age (MGI Ref ID J:141070)
- abnormal retinal progenitor cell morphology
- abnormal retinal rod bipolar cell morphology
- abnormal retinal rod cell morphology
nervous system phenotype
- abnormal retinal rod bipolar cell morphology
- abnormal retinal rod cell morphology
pigmentation phenotype
- abnormal retinal pigment epithelium morphology
- increased number of proliferating cells in the retinal pigment cell layer at 6 days of age (MGI Ref ID J:141070)
hematopoietic system phenotype
- increased spleen weight
- spleen weight elevated with dextran sodium sulfate treatment relative to controls (MGI Ref ID J:37271)
References
- Poltorak A; He X; Smirnova I; Liu MY; Huffel CV; Du X; Birdwell D; Alejos E; Silva M; Galanos C; Freudenberg M; Ricciardi-Castagnoli P; Layton B; Beutler B. 1998. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282(5396):2085-8. PubMed: 9851930MGI: J:51522
- Vogel SN; Hansen CT; Rosenstreich DL. 1979. Characterization of a congenitally LPS-resistant, athymic mouse strain. J Immunol 122(2):619-22. PubMed: 368244MGI: J:6086
Additional - Tlr4lps-del related
- Aachoui Y; Leaf IA; Hagar JA; Fontana MF; Campos CG; Zak DE; Tan MH; Cotter PA; Vance RE; Aderem A; Miao EA. 2013. Caspase-11 protects against bacteria that escape the vacuole. Science 339(6122):975-8. PubMed: 23348507MGI: J:193387
- Agace W; Hedges S; Svanborg C. 1992. Lps genotype in the C57 black mouse background and its influence on the interleukin-6 response to E. coli urinary tract infection. Scand J Immunol 35(5):531-8. PubMed: 1579857MGI: J:3436
- Amiel E; Alonso A; Uematsu S; Akira S; Poynter ME; Berwin B. 2009. Pivotal Advance: Toll-like receptor regulation of scavenger receptor-A-mediated phagocytosis. J Leukoc Biol 85(4):595-605. PubMed: 19112093MGI: J:146918
- An CH; Wang XM; Lam HC; Ifedigbo E; Washko GR; Ryter SW; Choi AM. 2012. TLR4 deficiency promotes autophagy during cigarette smoke-induced pulmonary emphysema. Am J Physiol Lung Cell Mol Physiol 303(9):L748-57. PubMed: 22983353MGI: J:193661
- Andonegui G; Kerfoot SM; McNagny K; Ebbert KV; Patel KD; Kubes P. 2005. Platelets express functional Toll-like receptor-4. Blood 106(7):2417-23. PubMed: 15961512MGI: J:119375
- Babelova A; Moreth K; Tsalastra-Greul W; Zeng-Brouwers J; Eickelberg O; Young MF; Bruckner P; Pfeilschifter J; Schaefer RM; Grone HJ; Schaefer L. 2009. Biglycan, a danger signal that activates the NLRP3 inflammasome via toll-like and P2X receptors. J Biol Chem 284(36):24035-48. PubMed: 19605353MGI: J:155256
- Beisswenger C; Lysenko ES; Weiser JN. 2009. Early bacterial colonization induces toll-like receptor-dependent transforming growth factor beta signaling in the epithelium. Infect Immun 77(5):2212-20. PubMed: 19255194MGI: J:148184
- Benabid R; Wartelle J; Malleret L; Guyot N; Gangloff S; Lebargy F; Belaaouaj A. 2012. Neutrophil elastase modulates cytokine expression: contribution to host defense against Pseudomonas aeruginosa-induced pneumonia. J Biol Chem 287(42):34883-94. PubMed: 22927440MGI: J:192139
- Berger SB; Romero X; Ma C; Wang G; Faubion WA; Liao G; Compeer E; Keszei M; Rameh L; Wang N; Boes M; Regueiro JR; Reinecker HC; Terhorst C. 2010. SLAM is a microbial sensor that regulates bacterial phagosome functions in macrophages. Nat Immunol 11(10):920-7. PubMed: 20818396MGI: J:164685
- Bhattacharyya S; Dudeja PK; Tobacman JK. 2008. Lipopolysaccharide activates NF-kappaB by TLR4-Bcl10-dependent and independent pathways in colonic epithelial cells. Am J Physiol Gastrointest Liver Physiol 295(4):G784-90. PubMed: 18718996MGI: J:142282
- Binck BW; Tsen MF; Islas M; White DJ; Schultz RA; Willis MS; Garcia JV; Horton JW; Thomas JA. 2005. Bone marrow-derived cells contribute to contractile dysfunction in endotoxic shock. Am J Physiol Heart Circ Physiol 288(2):H577-83. PubMed: 15458952MGI: J:96165
- Biragyn A; Coscia M; Nagashima K; Sanford M; Young HA; Olkhanud P. 2008. Murine beta-defensin 2 promotes TLR-4/MyD88-mediated and NF-kappaB-dependent atypical death of APCs via activation of TNFR2. J Leukoc Biol 83(4):998-1008. PubMed: 18192488MGI: J:134193
- Blich M; Golan A; Arvatz G; Sebbag A; Shafat I; Sabo E; Cohen-Kaplan V; Petcherski S; Avniel-Polak S; Eitan A; Hammerman H; Aronson D; Axelman E; Ilan N; Nussbaum G; Vlodavsky I. 2013. Macrophage activation by heparanase is mediated by TLR-2 and TLR-4 and associates with plaque progression. Arterioscler Thromb Vasc Biol 33(2):e56-65. PubMed: 23162016MGI: J:216913
- Bosmann M; Haggadone MD; Hemmila MR; Zetoune FS; Sarma JV; Ward PA. 2012. Complement activation product C5a is a selective suppressor of TLR4-induced, but not TLR3-induced, production of IL-27(p28) from macrophages. J Immunol 188(10):5086-93. PubMed: 22491257MGI: J:188678
- Bosmann M; Strobl B; Kichler N; Rigler D; Grailer JJ; Pache F; Murray PJ; Muller M; Ward PA. 2014. Tyrosine kinase 2 promotes sepsis-associated lethality by facilitating production of interleukin-27. J Leukoc Biol 96(1):123-31. PubMed: 24604832MGI: J:212012
- Brunn A; Mihelcic M; Carstov M; Feind L; Wieser EC; Schmidt J; Utermohlen O; Deckert M. 2017. Toll-Like Receptor 2, Toll-Like Receptor 4, Myeloid Differentiation Response Gene 88, and Toll-IL-1 Receptor Domain-Containing Adaptor-Inducing Interferon-gamma (TRIF) Selectively Regulate Susceptibility of P0106-125-Induced Murine Experimental Autoimmune Neuritis. Am J Pathol 187(1):42-54. PubMed: 27842213MGI: J:239101
- Burch LH; Yang IV; Whitehead GS; Chao FG; Berman KG; Schwartz DA. 2006. The transcriptional response to lipopolysaccharide reveals a role for interferon-gamma in lung neutrophil recruitment. Am J Physiol Lung Cell Mol Physiol 291(4):L677-82. PubMed: 16766576MGI: J:144404
- Burns E; Bachrach G; Shapira L; Nussbaum G. 2006. Cutting Edge: TLR2 is required for the innate response to Porphyromonas gingivalis: activation leads to bacterial persistence and TLR2 deficiency attenuates induced alveolar bone resorption. J Immunol 177(12):8296-300. PubMed: 17142724MGI: J:140676
- Byrne KT; Vonderheide RH. 2016. CD40 Stimulation Obviates Innate Sensors and Drives T Cell Immunity in Cancer. Cell Rep 15(12):2719-32. PubMed: 27292635MGI: J:238302
- Caballero MT; Serra ME; Acosta PL; Marzec J; Gibbons L; Salim M; Rodriguez A; Reynaldi A; Garcia A; Bado D; Buchholz UJ; Hijano DR; Coviello S; Newcomb D; Bellabarba M; Ferolla FM; Libster R; Berenstein A; Siniawaski S; Blumetti V; Echavarria M; Pinto L;Lawrence A; Ossorio MF; Grosman A; Mateu CG; Bayle C; Dericco A; Pellegrini M; Igarza I; Repetto HA; Grimaldi LA; Gudapati P; Polack NR; Althabe F; Shi M; Ferrero F; Bergel E; Stein RT; Peebles RS; Boothby M; Kleeberger SR; Polack FP. 2015. TLR4 genotype and environmental LPS mediate RSV bronchiolitis through Th2 polarization. J Clin Invest 125(2):571-82. PubMed: 25555213MGI: J:220399
- Carnevalli LS; Scognamiglio R; Cabezas-Wallscheid N; Rahmig S; Laurenti E; Masuda K; Jockel L; Kuck A; Sujer S; Polykratis A; Erlacher M; Pasparakis M; Essers MA; Trumpp A. 2014. Improved HSC reconstitution and protection from inflammatory stress and chemotherapy in mice lacking granzyme B. J Exp Med 211(5):769-79. PubMed: 24752302MGI: J:211304
- Carpentier PA; Dingman AL; Palmer TD. 2011. Placental TNF-alpha Signaling in Illness-Induced Complications of Pregnancy. Am J Pathol 178(6):2802-10. PubMed: 21641402MGI: J:173471
- Caso JR; Pradillo JM; Hurtado O; Lorenzo P; Moro MA; Lizasoain I. 2007. Toll-like receptor 4 is involved in brain damage and inflammation after experimental stroke. Circulation 115(12):1599-608. PubMed: 17372179MGI: J:133065
- Chabot S; Wagner JS; Farrant S; Neutra MR. 2006. TLRs regulate the gatekeeping functions of the intestinal follicle-associated epithelium. J Immunol 176(7):4275-83. PubMed: 16547265MGI: J:129895
- Chan YR; Liu JS; Pociask DA; Zheng M; Mietzner TA; Berger T; Mak TW; Clifton MC; Strong RK; Ray P; Kolls JK. 2009. Lipocalin 2 is required for pulmonary host defense against Klebsiella infection. J Immunol 182(8):4947-56. PubMed: 19342674MGI: J:147498
- Chandrakesan P; Jakkula LU; Ahmed I; Roy B; Anant S; Umar S. 2013. Differential effects of beta-catenin and NF-kappaB interplay in the regulation of cell proliferation, inflammation and tumorigenesis in response to bacterial infection. PLoS One 8(11):e79432. PubMed: 24278135MGI: J:209657
- Chassaing B; Ley RE; Gewirtz AT. 2014. Intestinal epithelial cell toll-like receptor 5 regulates the intestinal microbiota to prevent low-grade inflammation and metabolic syndrome in mice. Gastroenterology 147(6):1363-77.e17. PubMed: 25172014MGI: J:229155
- Chen J; Hartono JR; John R; Bennett M; Zhou XJ; Wang Y; Wu Q; Winterberg PD; Nagami GT; Lu CY. 2011. Early interleukin 6 production by leukocytes during ischemic acute kidney injury is regulated by TLR4. Kidney Int 80(5):504-15. PubMed: 21633411MGI: J:194804
- Chen J; John R; Richardson JA; Shelton JM; Zhou XJ; Wang Y; Wu QQ; Hartono JR; Winterberg PD; Lu CY. 2011. Toll-like receptor 4 regulates early endothelial activation during ischemic acute kidney injury. Kidney Int 79(3):288-99. PubMed: 20927041MGI: J:186890
- Chen J; Matzuk MM; Zhou XJ; Lu CY. 2012. Endothelial pentraxin 3 contributes to murine ischemic acute kidney injury. Kidney Int 82(11):1195-207. PubMed: 22895517MGI: J:198404
- Clarke TB; Davis KM; Lysenko ES; Zhou AY; Yu Y; Weiser JN. 2010. Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity. Nat Med 16(2):228-31. PubMed: 20081863MGI: J:157078
- Cohen-Sfady M; Pevsner-Fischer M; Margalit R; Cohen IR. 2009. Heat shock protein 60, via MyD88 innate signaling, protects B cells from apoptosis, spontaneous and induced. J Immunol 183(2):890-6. PubMed: 19561102MGI: J:151657
- Costalonga M; Zell T. 2007. Lipopolysaccharide enhances in vivo interleukin-2 production and proliferation by naive antigen-specific CD4 T cells via a Toll-like receptor 4-dependent mechanism. Immunology 122(1):124-30. PubMed: 17484770MGI: J:125617
- Csoka B; Nemeth ZH; Virag L; Gergely P; Leibovich SJ; Pacher P; Sun CX; Blackburn MR; Vizi ES; Deitch EA; Hasko G. 2007. A2A adenosine receptors and C/EBPbeta are crucially required for IL-10 production by macrophages exposed to Escherichia coli. Blood 110(7):2685-95. PubMed: 17525287MGI: J:147023
- Csoka B; Selmeczy Z; Koscso B; Nemeth ZH; Pacher P; Murray PJ; Kepka-Lenhart D; Morris SM Jr; Gause WC; Leibovich SJ; Hasko G. 2012. Adenosine promotes alternative macrophage activation via A2A and A2B receptors. FASEB J 26(1):376-86. PubMed: 21926236MGI: J:195612
- D'Avila H; Almeida PE; Roque NR; Castro-Faria-Neto HC; Bozza PT. 2007. Toll-Like Receptor-2-Mediated C-C Chemokine Receptor 3 and Eotaxin-Driven Eosinophil Influx Induced by Mycobacterium bovis BCG Pleurisy. Infect Immun 75(3):1507-11. PubMed: 17158890MGI: J:118500
- D'Avila H; Melo RC; Parreira GG; Werneck-Barroso E; Castro-Faria-Neto HC; Bozza PT. 2006. Mycobacterium bovis bacillus Calmette-Guerin induces TLR2-mediated formation of lipid bodies: intracellular domains for eicosanoid synthesis in vivo. J Immunol 176(5):3087-97. PubMed: 16493068MGI: J:129415
- Darville T; O'Neill JM; Andrews CW Jr; Nagarajan UM; Stahl L; Ojcius DM. 2003. Toll-like receptor-2, but not Toll-like receptor-4, is essential for development of oviduct pathology in chlamydial genital tract infection. J Immunol 171(11):6187-97. PubMed: 14634135MGI: J:106730
- Das S; Alhasson F; Dattaroy D; Pourhoseini S; Seth RK; Nagarkatti M; Nagarkatti PS; Michelotti GA; Diehl AM; Kalyanaraman B; Chatterjee S. 2015. NADPH Oxidase-Derived Peroxynitrite Drives Inflammation in Mice and Human Nonalcoholic Steatohepatitis via TLR4-Lipid Raft Recruitment. Am J Pathol 185(7):1944-57. PubMed: 25989356MGI: J:223295
- David MD; Cochrane CL; Duncan SK; Schrader JW. 2005. Pure lipopolysaccharide or synthetic lipid A induces activation of p21Ras in primary macrophages through a pathway dependent on Src family kinases and PI3K. J Immunol 175(12):8236-41. PubMed: 16339563MGI: J:122258
- Davis MJ; Gregorka B; Gestwicki JE; Swanson JA. 2012. Inducible renitence limits Listeria monocytogenes escape from vacuoles in macrophages. J Immunol 189(9):4488-95. PubMed: 23002437MGI: J:190625
- Desai MS; Mariscalco MM; Tawil A; Vallejo JG; Smith CW. 2008. Atherogenic diet-induced hepatitis is partially dependent on murine TLR4. J Leukoc Biol 83(6):1336-44. PubMed: 18334542MGI: J:136848
- Diehl SA; McElvany B; Noubade R; Seeberger N; Harding B; Spach K; Teuscher C. 2014. G proteins Galphai1/3 are critical targets for Bordetella pertussis toxin-induced vasoactive amine sensitization. Infect Immun 82(2):773-82. PubMed: 24478091MGI: J:209809
- Dong B; Qi D; Yang L; Huang Y; Xiao X; Tai N; Wen L; Wong FS. 2012. TLR4 regulates cardiac lipid accumulation and diabetic heart disease in the nonobese diabetic mouse model of type 1 diabetes. Am J Physiol Heart Circ Physiol 303(6):H732-42. PubMed: 22842069MGI: J:191323
- Dvoriantchikova G; Barakat DJ; Hernandez E; Shestopalov VI; Ivanov D. 2010. Toll-like receptor 4 contributes to retinal ischemia/reperfusion injury. Mol Vis 16:1907-12. PubMed: 21031135MGI: J:167913
- Ehl S; Bischoff R; Ostler T; Vallbracht S; Schulte-Monting J; Poltorak A; Freudenberg M. 2004. The role of Toll-like receptor 4 versus interleukin-12 in immunity to respiratory syncytial virus. Eur J Immunol 34(4):1146-53. PubMed: 15048726MGI: J:88878
- Espinassous Q; Garcia-de-Paco E; Garcia-Verdugo I; Synguelakis M; von Aulock S; Sallenave JM; McKenzie AN; Kanellopoulos J. 2009. IL-33 enhances lipopolysaccharide-induced inflammatory cytokine production from mouse macrophages by regulating lipopolysaccharide receptor complex. J Immunol 183(2):1446-55. PubMed: 19553541MGI: J:151399
- Fan W; Morinaga H; Kim JJ; Bae E; Spann NJ; Heinz S; Glass CK; Olefsky JM. 2010. FoxO1 regulates Tlr4 inflammatory pathway signalling in macrophages. EMBO J 29(24):4223-36. PubMed: 21045807MGI: J:167177
- Fejer G; Wegner MD; Gyory I; Cohen I; Engelhard P; Voronov E; Manke T; Ruzsics Z; Dolken L; Prazeres da Costa O; Branzk N; Huber M; Prasse A; Schneider R; Apte RN; Galanos C; Freudenberg MA. 2013. Nontransformed, GM-CSF-dependent macrophage lines are a unique model to study tissue macrophage functions. Proc Natl Acad Sci U S A 110(24):E2191-8. PubMed: 23708119MGI: J:197404
- Fellner L; Irschick R; Schanda K; Reindl M; Klimaschewski L; Poewe W; Wenning GK; Stefanova N. 2013. Toll-like receptor 4 is required for alpha-synuclein dependent activation of microglia and astroglia. Glia 61(3):349-60. PubMed: 23108585MGI: J:191118
- Feng X; Deng T; Zhang Y; Su S; Wei C; Han D. 2011. Lipopolysaccharide inhibits macrophage phagocytosis of apoptotic neutrophils by regulating the production of tumour necrosis factor alpha and growth arrest-specific gene 6. Immunology 132(2):287-95. PubMed: 21039473MGI: J:168633
- Freeman JJ; Feng Y; Demehri FR; Dempsey PJ; Teitelbaum DH. 2015. TPN-associated intestinal epithelial cell atrophy is modulated by TLR4/EGF signaling pathways. FASEB J 29(7):2943-58. PubMed: 25782989MGI: J:225472
- Ganta RR; Wilkerson MJ; Cheng C; Rokey AM; Chapes SK. 2002. Persistent Ehrlichia chaffeensis infection occurs in the absence of functional major histocompatibility complex class II genes. Infect Immun 70(1):380-8. PubMed: 11748204MGI: J:74569
- Gao W; Wang H; Zhang L; Cao Y; Bao JZ; Liu ZX; Wang LS; Yang Q; Lu X. 2016. Retinol-Binding Protein 4 Induces Cardiomyocyte Hypertrophy by Activating TLR4/MyD88 Pathway. Endocrinology 157(6):2282-93. PubMed: 27100622MGI: J:235169
- Ghosh S; Adisa OA; Chappa P; Tan F; Jackson KA; Archer DR; Ofori-Acquah SF. 2013. Extracellular hemin crisis triggers acute chest syndrome in sickle mice. J Clin Invest :. PubMed: 24084741MGI: J:203987
- Good DW; George T; Watts BA 3rd. 2012. Toll-like receptor 2 is required for LPS-induced Toll-like receptor 4 signaling and inhibition of ion transport in renal thick ascending limb. J Biol Chem 287(24):20208-20. PubMed: 22523073MGI: J:186513
- Goodyear A; Troyer R; Bielefeldt-Ohmann H; Dow S. 2012. MyD88-Dependent Recruitment of Monocytes and Dendritic Cells Required for Protection from Pulmonary Burkholderia mallei Infection. Infect Immun 80(1):110-20. PubMed: 22025508MGI: J:178961
- Gulden E; Ihira M; Ohashi A; Reinbeck AL; Freudenberg MA; Kolb H; Burkart V. 2013. Toll-like receptor 4 deficiency accelerates the development of insulin-deficient diabetes in non-obese diabetic mice. PLoS One 8(9):e75385. PubMed: 24086519MGI: J:207741
- Gurkan S; Cabinian A; Lopez V; Bhaumik M; Chang JM; Rabson AB; Mundel P. 2013. Inhibition of type I interferon signalling prevents TLR ligand-mediated proteinuria. J Pathol 231(2):248-56. PubMed: 24151637MGI: J:201950
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