JAX
Mouse Strain Datasheet - 007227
B6.B10ScN-Tlr4lps-del/JthJ
The Tlr4Lps-del spontaneous mutation exhibits a defective response to LPS stimulation and affects Toll signaling pathways involved with inflammation, including susceptibility to various bacterial infections, effects of tissue ischemia (including cerebral and retinal ischemia), myocardial infarction, neurodegeneration, and tumor immune responses.
Read More +Genetic overview
| Genetic Background | Generation |
|---|---|
|
C57BL/6 |
N6+N2F7
|
Tlr4lps-del
| Allele Type | Gene Symbol | Gene Name |
|---|---|---|
| Spontaneous | Tlr4 | toll-like receptor 4 |
Research Applications
- Immunology, Inflammation and Autoimmunity Research
Detailed Description
The stimulation of Toll-like receptor 4 (TLR4) by lipopolysaccharide (LPS) induces the release of proinflammatory cytokines that activate immune responses. The Tlr4Lps-del spontaneous mutation corresponds to a 74723 bp deletion that completely removes the Tlr4 coding sequence. No mRNA or protein is expressed. Homozygous mutants exhibit a defective response to LPS stimulation. The functionally similar Tlr4Lps-d mutation found in C3H/HeJ mice (#000659) is a point mutation that causes an amino acid substitution.
Tlr4 -deficient mice display significantly reduced expression of proinflammatory genes compared to controls 24 h after reperfusion triggered by retinal ischemic injury. These include transcriptional factor p65 (Rela), tumor necrosis factor (Thf), interleukin 6 (Il6), chemokine (C-C motif) ligand 2 (Ccl2), chemokine (C-C motif) ligand 5 (Ccl5), chemokine (C-X-C motif) ligand 10 (Cxcl10), cytochrome b-245, beta polypeptide (Cybb), nitric oxide synthase 2 (Nos2), and intercellular adhesion molecule 1 (Icam1) (Dvoriantchikova et al., 2010).
The effect of TLR4 on tumor progression appears to depend on which cells TLR4 resides and the particular ligand involved. For example, enhanced prostrate tumor progression as a result of TLR4 response to a tumor-derived ligand such as Peroxiredoxin is not seen in the Tlr4 deficient mutant mice (Riddell et al., 2011). Conversely, tumor inhibition seen in wild type mice when B16 melanoma cells were stimulated in vitro with LPS was not seen in mutant mice (Nunez et al., 2012).
TLR4 signaling may also act as innate neuroprotective mechanism through clearance of alpha-synuclein as TLR4 ablation impairs the phagocytic response of microglia to alpha-synuclein and enhances neurodegeneration (Stefanova et al. 2011).
Development
Abnormal response to lipopolysaccharide was observed in the inbred strain C57BL/10ScN in the 1970s. The phenotype was subsequently identified as a mutation in the Tlr4 gene. This strain originated from the C57BL/10ScN colony at NCI Frederick and was transferred to the laboratory of Dr. James Thomas, University of Texas Southwestern Medical Center. The allele was introgressed into C57BL/6 by backcrossing for at least five generations. The strain was donated to The Jackson Laboratory Repository in 2008.
Control Suggestions
Selected References
- Poltorak A; He X; Smirnova I; Liu MY; Huffel CV; Du X; Birdwell D; Alejos E; Silva M; Galanos C; Freudenberg M; Ricciardi-Castagnoli P; Layton B; Beutler B. 1998. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282(5396):2085-8. PubMed: 9851930MGI: J:51522
- Vogel SN; Hansen CT; Rosenstreich DL. 1979. Characterization of a congenitally LPS-resistant, athymic mouse strain. J Immunol 122(2):619-22. PubMed: 368244MGI: J:6086
Tlr4lps-del
Allele Symbol: Tlr4lps-del
| Allele Name | defective lipopolysaccharide response, deletion |
|---|---|
| Allele Type | Spontaneous |
| Allele Synonym(s) | TLR4-KO; TLR4lps-; Tlr4- |
| Gene Symbol and Name | Tlr4, toll-like receptor 4 |
| Gene Synonym(s) | ARMD10; CD284; Lps; Lps; RAS-like, family 2, locus 8; Rasl2-8; Rasl2-8; TLR-4; TOLL; lipopolysaccharide response; lipopolysaccharide response |
| Strain of Origin | C57BL/10ScN |
| Chromosome | 4 |
| General Note | C57BL/10ScN, C57BL/10ScNJ, and C57BL10/ScCr mice carry this allele. |
| Molecular Note | This allele has been characterized by lack of mRNA owing to a deletion of the locus. 74723bp of genomic DNA sequence have been removed, apparently encompasing only the Tlr4 gene. |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Immunology, Inflammation and Autoimmunity Research
- CD Antigens, Antigen Receptors, and Histocompatibility Markers
- Tlr deficiency
- Immunodeficiency
- Tlr deficiency
- Inflammation
- Tlr deficiency
- CD Antigens, Antigen Receptors, and Histocompatibility Markers
Genotype: Tlr4lps-del related
- Immunology, Inflammation and Autoimmunity Research
- CD Antigens, Antigen Receptors, and Histocompatibility Markers
- Tlr deficiency
- Immunodeficiency
- Tlr deficiency
- Inflammation
- Tlr deficiency
- CD Antigens, Antigen Receptors, and Histocompatibility Markers
Mammalian Phenotype Terms by Genotype
The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain
Genotype: Tlr4lps-del/Tlr4lps-del
C57BL/10ScCr
immune system phenotype
- abnormal cytokine secretion
- higher levels of Th1 and Th2 cytokines secreted at 4 weeks after infection with Leishmania major than in controls (MGI Ref ID J:88996)
- abnormal macrophage physiology
- poor activation of macrophage by Leishmania major (MGI Ref ID J:88996)
- increased susceptibility to bacterial infection
behavior/neurological phenotype
- hyporesponsive to tactile stimuli
- attenuated mechanical allodynia after nerve injury (MGI Ref ID J:97819)
- increased thermal nociceptive threshold
- attenuated response to heat (MGI Ref ID J:97819)
nervous system phenotype
- abnormal glial cell physiology
- glial activation after nerve injury reduced (MGI Ref ID J:97819)
cardiovascular system phenotype
- decreased response of heart to induced stress
- exhibit reduced cardiac hypertrophy following pressure overload compared to controls (MGI Ref ID J:106358)
homeostasis/metabolism phenotype
- decreased response of heart to induced stress
- exhibit reduced cardiac hypertrophy following pressure overload compared to controls (MGI Ref ID J:106358)
- decreased susceptibility to injury
integument phenotype
- hyporesponsive to tactile stimuli
- attenuated mechanical allodynia after nerve injury (MGI Ref ID J:97819)
- increased thermal nociceptive threshold
- attenuated response to heat (MGI Ref ID J:97819)
hematopoietic system phenotype
- abnormal macrophage physiology
- poor activation of macrophage by Leishmania major (MGI Ref ID J:88996)
Genotype: Tlr4lps-del/Tlr4lps-del
involves: C57BL/10ScN
immune system phenotype
- abnormal tumor necrosis factor level
- diminished TNF alpha expression after 90 minutes of liver ischemia followed by 6 hours of reperfusion (MGI Ref ID J:114368)
- decreased interleukin-10 secretion
- production is suppressed in response to E coli with or without adenosine (MGI Ref ID J:147023)
- decreased interleukin-6 secretion
- production is suppressed in response to E coli (MGI Ref ID J:147023)
homeostasis/metabolism phenotype
- abnormal circulating enzyme level
- abnormal tumor necrosis factor level
- diminished TNF alpha expression after 90 minutes of liver ischemia followed by 6 hours of reperfusion (MGI Ref ID J:114368)
- decreased circulating alanine transaminase level
- serum levels decreased after 90 minutes of liver ischemia followed by 6 hours of reperfusion (MGI Ref ID J:114368)
nervous system phenotype
- CNS ischemia
- abnormal neuron differentiation
cellular phenotype
Genotype: Tlr4lps-del/Tlr4lps-del
C57BL/10ScN
digestive/alimentary phenotype
- rectal hemorrhage
- rectal bleeding after 7 days of dextran sodium sulfate treatment is reduced relative to controls (MGI Ref ID J:37271)
cardiovascular system phenotype
- rectal hemorrhage
- rectal bleeding after 7 days of dextran sodium sulfate treatment is reduced relative to controls (MGI Ref ID J:37271)
immune system phenotype
- increased spleen weight
- spleen weight elevated with dextran sodium sulfate treatment relative to controls (MGI Ref ID J:37271)
respiratory system phenotype
- abnormal pulmonary alveolar duct morphology
- enlarged air spaces distal to the terminal bronchioles (MGI Ref ID J:114985)
- abnormal pulmonary alveolus morphology
- destruction of normal alveolar structures (MGI Ref ID J:114985)
- enlarged lung
- significantly increased lung volume at 3 months of age in contrast to normal body weights through 12 months (MGI Ref ID J:114985)
skeleton phenotype
- increased bone mass
- larger bones at 20-24 weeks of age (MGI Ref ID J:118467)
- increased bone mineral content
- greater mineral content at 20-24 weeks (MGI Ref ID J:118467)
adipose tissue phenotype
- decreased percent body fat/body weight
- 70% less body fat (MGI Ref ID J:118467)
vision/eye phenotype
- abnormal retinal layer morphology
- (MGI Ref ID J:141070)
- abnormal retinal pigment epithelium morphology
- increased number of proliferating cells in the retinal pigment cell layer at 6 days of age (MGI Ref ID J:141070)
- abnormal retinal progenitor cell morphology
- abnormal retinal rod bipolar cell morphology
- abnormal retinal rod cell morphology
nervous system phenotype
- abnormal retinal rod bipolar cell morphology
- abnormal retinal rod cell morphology
pigmentation phenotype
- abnormal retinal pigment epithelium morphology
- increased number of proliferating cells in the retinal pigment cell layer at 6 days of age (MGI Ref ID J:141070)
hematopoietic system phenotype
- increased spleen weight
- spleen weight elevated with dextran sodium sulfate treatment relative to controls (MGI Ref ID J:37271)
References
- Poltorak A; He X; Smirnova I; Liu MY; Huffel CV; Du X; Birdwell D; Alejos E; Silva M; Galanos C; Freudenberg M; Ricciardi-Castagnoli P; Layton B; Beutler B. 1998. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282(5396):2085-8. PubMed: 9851930MGI: J:51522
- Vogel SN; Hansen CT; Rosenstreich DL. 1979. Characterization of a congenitally LPS-resistant, athymic mouse strain. J Immunol 122(2):619-22. PubMed: 368244MGI: J:6086
Additional - Tlr4lps-del related
- Aachoui Y; Leaf IA; Hagar JA; Fontana MF; Campos CG; Zak DE; Tan MH; Cotter PA; Vance RE; Aderem A; Miao EA. 2013. Caspase-11 protects against bacteria that escape the vacuole. Science 339(6122):975-8. PubMed: 23348507MGI: J:193387
- Agace W; Hedges S; Svanborg C. 1992. Lps genotype in the C57 black mouse background and its influence on the interleukin-6 response to E. coli urinary tract infection. Scand J Immunol 35(5):531-8. PubMed: 1579857MGI: J:3436
- Amiel E; Alonso A; Uematsu S; Akira S; Poynter ME; Berwin B. 2009. Pivotal Advance: Toll-like receptor regulation of scavenger receptor-A-mediated phagocytosis. J Leukoc Biol 85(4):595-605. PubMed: 19112093MGI: J:146918
- An CH; Wang XM; Lam HC; Ifedigbo E; Washko GR; Ryter SW; Choi AM. 2012. TLR4 deficiency promotes autophagy during cigarette smoke-induced pulmonary emphysema. Am J Physiol Lung Cell Mol Physiol 303(9):L748-57. PubMed: 22983353MGI: J:193661
- Andonegui G; Kerfoot SM; McNagny K; Ebbert KV; Patel KD; Kubes P. 2005. Platelets express functional Toll-like receptor-4. Blood 106(7):2417-23. PubMed: 15961512MGI: J:119375
- Babelova A; Moreth K; Tsalastra-Greul W; Zeng-Brouwers J; Eickelberg O; Young MF; Bruckner P; Pfeilschifter J; Schaefer RM; Grone HJ; Schaefer L. 2009. Biglycan, a danger signal that activates the NLRP3 inflammasome via toll-like and P2X receptors. J Biol Chem 284(36):24035-48. PubMed: 19605353MGI: J:155256
- Beisswenger C; Lysenko ES; Weiser JN. 2009. Early bacterial colonization induces toll-like receptor-dependent transforming growth factor beta signaling in the epithelium. Infect Immun 77(5):2212-20. PubMed: 19255194MGI: J:148184
- Benabid R; Wartelle J; Malleret L; Guyot N; Gangloff S; Lebargy F; Belaaouaj A. 2012. Neutrophil elastase modulates cytokine expression: contribution to host defense against Pseudomonas aeruginosa-induced pneumonia. J Biol Chem 287(42):34883-94. PubMed: 22927440MGI: J:192139
- Berger SB; Romero X; Ma C; Wang G; Faubion WA; Liao G; Compeer E; Keszei M; Rameh L; Wang N; Boes M; Regueiro JR; Reinecker HC; Terhorst C. 2010. SLAM is a microbial sensor that regulates bacterial phagosome functions in macrophages. Nat Immunol 11(10):920-7. PubMed: 20818396MGI: J:164685
- Bhattacharyya S; Dudeja PK; Tobacman JK. 2008. Lipopolysaccharide activates NF-kappaB by TLR4-Bcl10-dependent and independent pathways in colonic epithelial cells. Am J Physiol Gastrointest Liver Physiol 295(4):G784-90. PubMed: 18718996MGI: J:142282
- Binck BW; Tsen MF; Islas M; White DJ; Schultz RA; Willis MS; Garcia JV; Horton JW; Thomas JA. 2005. Bone marrow-derived cells contribute to contractile dysfunction in endotoxic shock. Am J Physiol Heart Circ Physiol 288(2):H577-83. PubMed: 15458952MGI: J:96165
- Biragyn A; Coscia M; Nagashima K; Sanford M; Young HA; Olkhanud P. 2008. Murine beta-defensin 2 promotes TLR-4/MyD88-mediated and NF-kappaB-dependent atypical death of APCs via activation of TNFR2. J Leukoc Biol 83(4):998-1008. PubMed: 18192488MGI: J:134193
- Blich M; Golan A; Arvatz G; Sebbag A; Shafat I; Sabo E; Cohen-Kaplan V; Petcherski S; Avniel-Polak S; Eitan A; Hammerman H; Aronson D; Axelman E; Ilan N; Nussbaum G; Vlodavsky I. 2013. Macrophage activation by heparanase is mediated by TLR-2 and TLR-4 and associates with plaque progression. Arterioscler Thromb Vasc Biol 33(2):e56-65. PubMed: 23162016MGI: J:216913
- Bosmann M; Haggadone MD; Hemmila MR; Zetoune FS; Sarma JV; Ward PA. 2012. Complement activation product C5a is a selective suppressor of TLR4-induced, but not TLR3-induced, production of IL-27(p28) from macrophages. J Immunol 188(10):5086-93. PubMed: 22491257MGI: J:188678
- Bosmann M; Strobl B; Kichler N; Rigler D; Grailer JJ; Pache F; Murray PJ; Muller M; Ward PA. 2014. Tyrosine kinase 2 promotes sepsis-associated lethality by facilitating production of interleukin-27. J Leukoc Biol 96(1):123-31. PubMed: 24604832MGI: J:212012
- Brunn A; Mihelcic M; Carstov M; Feind L; Wieser EC; Schmidt J; Utermohlen O; Deckert M. 2017. Toll-Like Receptor 2, Toll-Like Receptor 4, Myeloid Differentiation Response Gene 88, and Toll-IL-1 Receptor Domain-Containing Adaptor-Inducing Interferon-gamma (TRIF) Selectively Regulate Susceptibility of P0106-125-Induced Murine Experimental Autoimmune Neuritis. Am J Pathol 187(1):42-54. PubMed: 27842213MGI: J:239101
- Burch LH; Yang IV; Whitehead GS; Chao FG; Berman KG; Schwartz DA. 2006. The transcriptional response to lipopolysaccharide reveals a role for interferon-gamma in lung neutrophil recruitment. Am J Physiol Lung Cell Mol Physiol 291(4):L677-82. PubMed: 16766576MGI: J:144404
- Burns E; Bachrach G; Shapira L; Nussbaum G. 2006. Cutting Edge: TLR2 is required for the innate response to Porphyromonas gingivalis: activation leads to bacterial persistence and TLR2 deficiency attenuates induced alveolar bone resorption. J Immunol 177(12):8296-300. PubMed: 17142724MGI: J:140676
- Byrne KT; Vonderheide RH. 2016. CD40 Stimulation Obviates Innate Sensors and Drives T Cell Immunity in Cancer. Cell Rep 15(12):2719-32. PubMed: 27292635MGI: J:238302
- Caballero MT; Serra ME; Acosta PL; Marzec J; Gibbons L; Salim M; Rodriguez A; Reynaldi A; Garcia A; Bado D; Buchholz UJ; Hijano DR; Coviello S; Newcomb D; Bellabarba M; Ferolla FM; Libster R; Berenstein A; Siniawaski S; Blumetti V; Echavarria M; Pinto L;Lawrence A; Ossorio MF; Grosman A; Mateu CG; Bayle C; Dericco A; Pellegrini M; Igarza I; Repetto HA; Grimaldi LA; Gudapati P; Polack NR; Althabe F; Shi M; Ferrero F; Bergel E; Stein RT; Peebles RS; Boothby M; Kleeberger SR; Polack FP. 2015. TLR4 genotype and environmental LPS mediate RSV bronchiolitis through Th2 polarization. J Clin Invest 125(2):571-82. PubMed: 25555213MGI: J:220399
- Carnevalli LS; Scognamiglio R; Cabezas-Wallscheid N; Rahmig S; Laurenti E; Masuda K; Jockel L; Kuck A; Sujer S; Polykratis A; Erlacher M; Pasparakis M; Essers MA; Trumpp A. 2014. Improved HSC reconstitution and protection from inflammatory stress and chemotherapy in mice lacking granzyme B. J Exp Med 211(5):769-79. PubMed: 24752302MGI: J:211304
- Carpentier PA; Dingman AL; Palmer TD. 2011. Placental TNF-alpha Signaling in Illness-Induced Complications of Pregnancy. Am J Pathol 178(6):2802-10. PubMed: 21641402MGI: J:173471
- Caso JR; Pradillo JM; Hurtado O; Lorenzo P; Moro MA; Lizasoain I. 2007. Toll-like receptor 4 is involved in brain damage and inflammation after experimental stroke. Circulation 115(12):1599-608. PubMed: 17372179MGI: J:133065
- Chabot S; Wagner JS; Farrant S; Neutra MR. 2006. TLRs regulate the gatekeeping functions of the intestinal follicle-associated epithelium. J Immunol 176(7):4275-83. PubMed: 16547265MGI: J:129895
- Chan YR; Liu JS; Pociask DA; Zheng M; Mietzner TA; Berger T; Mak TW; Clifton MC; Strong RK; Ray P; Kolls JK. 2009. Lipocalin 2 is required for pulmonary host defense against Klebsiella infection. J Immunol 182(8):4947-56. PubMed: 19342674MGI: J:147498
- Chandrakesan P; Jakkula LU; Ahmed I; Roy B; Anant S; Umar S. 2013. Differential effects of beta-catenin and NF-kappaB interplay in the regulation of cell proliferation, inflammation and tumorigenesis in response to bacterial infection. PLoS One 8(11):e79432. PubMed: 24278135MGI: J:209657
- Chassaing B; Ley RE; Gewirtz AT. 2014. Intestinal epithelial cell toll-like receptor 5 regulates the intestinal microbiota to prevent low-grade inflammation and metabolic syndrome in mice. Gastroenterology 147(6):1363-77.e17. PubMed: 25172014MGI: J:229155
- Chen J; Hartono JR; John R; Bennett M; Zhou XJ; Wang Y; Wu Q; Winterberg PD; Nagami GT; Lu CY. 2011. Early interleukin 6 production by leukocytes during ischemic acute kidney injury is regulated by TLR4. Kidney Int 80(5):504-15. PubMed: 21633411MGI: J:194804
- Chen J; John R; Richardson JA; Shelton JM; Zhou XJ; Wang Y; Wu QQ; Hartono JR; Winterberg PD; Lu CY. 2011. Toll-like receptor 4 regulates early endothelial activation during ischemic acute kidney injury. Kidney Int 79(3):288-99. PubMed: 20927041MGI: J:186890
- Chen J; Matzuk MM; Zhou XJ; Lu CY. 2012. Endothelial pentraxin 3 contributes to murine ischemic acute kidney injury. Kidney Int 82(11):1195-207. PubMed: 22895517MGI: J:198404
- Clarke TB; Davis KM; Lysenko ES; Zhou AY; Yu Y; Weiser JN. 2010. Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity. Nat Med 16(2):228-31. PubMed: 20081863MGI: J:157078
- Cohen-Sfady M; Pevsner-Fischer M; Margalit R; Cohen IR. 2009. Heat shock protein 60, via MyD88 innate signaling, protects B cells from apoptosis, spontaneous and induced. J Immunol 183(2):890-6. PubMed: 19561102MGI: J:151657
- Costalonga M; Zell T. 2007. Lipopolysaccharide enhances in vivo interleukin-2 production and proliferation by naive antigen-specific CD4 T cells via a Toll-like receptor 4-dependent mechanism. Immunology 122(1):124-30. PubMed: 17484770MGI: J:125617
- Csoka B; Nemeth ZH; Virag L; Gergely P; Leibovich SJ; Pacher P; Sun CX; Blackburn MR; Vizi ES; Deitch EA; Hasko G. 2007. A2A adenosine receptors and C/EBPbeta are crucially required for IL-10 production by macrophages exposed to Escherichia coli. Blood 110(7):2685-95. PubMed: 17525287MGI: J:147023
- Csoka B; Selmeczy Z; Koscso B; Nemeth ZH; Pacher P; Murray PJ; Kepka-Lenhart D; Morris SM Jr; Gause WC; Leibovich SJ; Hasko G. 2012. Adenosine promotes alternative macrophage activation via A2A and A2B receptors. FASEB J 26(1):376-86. PubMed: 21926236MGI: J:195612
- D'Avila H; Almeida PE; Roque NR; Castro-Faria-Neto HC; Bozza PT. 2007. Toll-Like Receptor-2-Mediated C-C Chemokine Receptor 3 and Eotaxin-Driven Eosinophil Influx Induced by Mycobacterium bovis BCG Pleurisy. Infect Immun 75(3):1507-11. PubMed: 17158890MGI: J:118500
- D'Avila H; Melo RC; Parreira GG; Werneck-Barroso E; Castro-Faria-Neto HC; Bozza PT. 2006. Mycobacterium bovis bacillus Calmette-Guerin induces TLR2-mediated formation of lipid bodies: intracellular domains for eicosanoid synthesis in vivo. J Immunol 176(5):3087-97. PubMed: 16493068MGI: J:129415
- Darville T; O'Neill JM; Andrews CW Jr; Nagarajan UM; Stahl L; Ojcius DM. 2003. Toll-like receptor-2, but not Toll-like receptor-4, is essential for development of oviduct pathology in chlamydial genital tract infection. J Immunol 171(11):6187-97. PubMed: 14634135MGI: J:106730
- Das S; Alhasson F; Dattaroy D; Pourhoseini S; Seth RK; Nagarkatti M; Nagarkatti PS; Michelotti GA; Diehl AM; Kalyanaraman B; Chatterjee S. 2015. NADPH Oxidase-Derived Peroxynitrite Drives Inflammation in Mice and Human Nonalcoholic Steatohepatitis via TLR4-Lipid Raft Recruitment. Am J Pathol 185(7):1944-57. PubMed: 25989356MGI: J:223295
- David MD; Cochrane CL; Duncan SK; Schrader JW. 2005. Pure lipopolysaccharide or synthetic lipid A induces activation of p21Ras in primary macrophages through a pathway dependent on Src family kinases and PI3K. J Immunol 175(12):8236-41. PubMed: 16339563MGI: J:122258
- Davis MJ; Gregorka B; Gestwicki JE; Swanson JA. 2012. Inducible renitence limits Listeria monocytogenes escape from vacuoles in macrophages. J Immunol 189(9):4488-95. PubMed: 23002437MGI: J:190625
- Desai MS; Mariscalco MM; Tawil A; Vallejo JG; Smith CW. 2008. Atherogenic diet-induced hepatitis is partially dependent on murine TLR4. J Leukoc Biol 83(6):1336-44. PubMed: 18334542MGI: J:136848
- Diehl SA; McElvany B; Noubade R; Seeberger N; Harding B; Spach K; Teuscher C. 2014. G proteins Galphai1/3 are critical targets for Bordetella pertussis toxin-induced vasoactive amine sensitization. Infect Immun 82(2):773-82. PubMed: 24478091MGI: J:209809
- Dong B; Qi D; Yang L; Huang Y; Xiao X; Tai N; Wen L; Wong FS. 2012. TLR4 regulates cardiac lipid accumulation and diabetic heart disease in the nonobese diabetic mouse model of type 1 diabetes. Am J Physiol Heart Circ Physiol 303(6):H732-42. PubMed: 22842069MGI: J:191323
- Dvoriantchikova G; Barakat DJ; Hernandez E; Shestopalov VI; Ivanov D. 2010. Toll-like receptor 4 contributes to retinal ischemia/reperfusion injury. Mol Vis 16:1907-12. PubMed: 21031135MGI: J:167913
- Ehl S; Bischoff R; Ostler T; Vallbracht S; Schulte-Monting J; Poltorak A; Freudenberg M. 2004. The role of Toll-like receptor 4 versus interleukin-12 in immunity to respiratory syncytial virus. Eur J Immunol 34(4):1146-53. PubMed: 15048726MGI: J:88878
- Espinassous Q; Garcia-de-Paco E; Garcia-Verdugo I; Synguelakis M; von Aulock S; Sallenave JM; McKenzie AN; Kanellopoulos J. 2009. IL-33 enhances lipopolysaccharide-induced inflammatory cytokine production from mouse macrophages by regulating lipopolysaccharide receptor complex. J Immunol 183(2):1446-55. PubMed: 19553541MGI: J:151399
- Fan W; Morinaga H; Kim JJ; Bae E; Spann NJ; Heinz S; Glass CK; Olefsky JM. 2010. FoxO1 regulates Tlr4 inflammatory pathway signalling in macrophages. EMBO J 29(24):4223-36. PubMed: 21045807MGI: J:167177
- Fejer G; Wegner MD; Gyory I; Cohen I; Engelhard P; Voronov E; Manke T; Ruzsics Z; Dolken L; Prazeres da Costa O; Branzk N; Huber M; Prasse A; Schneider R; Apte RN; Galanos C; Freudenberg MA. 2013. Nontransformed, GM-CSF-dependent macrophage lines are a unique model to study tissue macrophage functions. Proc Natl Acad Sci U S A 110(24):E2191-8. PubMed: 23708119MGI: J:197404
- Fellner L; Irschick R; Schanda K; Reindl M; Klimaschewski L; Poewe W; Wenning GK; Stefanova N. 2013. Toll-like receptor 4 is required for alpha-synuclein dependent activation of microglia and astroglia. Glia 61(3):349-60. PubMed: 23108585MGI: J:191118
- Feng X; Deng T; Zhang Y; Su S; Wei C; Han D. 2011. Lipopolysaccharide inhibits macrophage phagocytosis of apoptotic neutrophils by regulating the production of tumour necrosis factor alpha and growth arrest-specific gene 6. Immunology 132(2):287-95. PubMed: 21039473MGI: J:168633
- Freeman JJ; Feng Y; Demehri FR; Dempsey PJ; Teitelbaum DH. 2015. TPN-associated intestinal epithelial cell atrophy is modulated by TLR4/EGF signaling pathways. FASEB J 29(7):2943-58. PubMed: 25782989MGI: J:225472
- Ganta RR; Wilkerson MJ; Cheng C; Rokey AM; Chapes SK. 2002. Persistent Ehrlichia chaffeensis infection occurs in the absence of functional major histocompatibility complex class II genes. Infect Immun 70(1):380-8. PubMed: 11748204MGI: J:74569
- Gao W; Wang H; Zhang L; Cao Y; Bao JZ; Liu ZX; Wang LS; Yang Q; Lu X. 2016. Retinol-Binding Protein 4 Induces Cardiomyocyte Hypertrophy by Activating TLR4/MyD88 Pathway. Endocrinology 157(6):2282-93. PubMed: 27100622MGI: J:235169
- Ghosh S; Adisa OA; Chappa P; Tan F; Jackson KA; Archer DR; Ofori-Acquah SF. 2013. Extracellular hemin crisis triggers acute chest syndrome in sickle mice. J Clin Invest :. PubMed: 24084741MGI: J:203987
- Good DW; George T; Watts BA 3rd. 2012. Toll-like receptor 2 is required for LPS-induced Toll-like receptor 4 signaling and inhibition of ion transport in renal thick ascending limb. J Biol Chem 287(24):20208-20. PubMed: 22523073MGI: J:186513
- Goodyear A; Troyer R; Bielefeldt-Ohmann H; Dow S. 2012. MyD88-Dependent Recruitment of Monocytes and Dendritic Cells Required for Protection from Pulmonary Burkholderia mallei Infection. Infect Immun 80(1):110-20. PubMed: 22025508MGI: J:178961
- Gulden E; Ihira M; Ohashi A; Reinbeck AL; Freudenberg MA; Kolb H; Burkart V. 2013. Toll-like receptor 4 deficiency accelerates the development of insulin-deficient diabetes in non-obese diabetic mice. PLoS One 8(9):e75385. PubMed: 24086519MGI: J:207741
- Gurkan S; Cabinian A; Lopez V; Bhaumik M; Chang JM; Rabson AB; Mundel P. 2013. Inhibition of type I interferon signalling prevents TLR ligand-mediated proteinuria. J Pathol 231(2):248-56. PubMed: 24151637MGI: J:201950
- Ha T; Li Y; Hua F; Ma J; Gao X; Kelley J; Zhao A; Haddad GE; Williams DL; William Browder I; Kao RL; Li C. 2005. Reduced cardiac hypertrophy in toll-like receptor 4-deficient mice following pressure overload. Cardiovasc Res 68(2):224-34. PubMed: 15967420MGI: J:106358
- Hagar JA; Powell DA; Aachoui Y; Ernst RK; Miao EA. 2013. Cytoplasmic LPS activates caspase-11: implications in TLR4-independent endotoxic shock. Science 341(6151):1250-3. PubMed: 24031018MGI: J:201144
- Haziot A; Hijiya N; Gangloff SC; Silver J; Goyert SM. 2001. Induction of a novel mechanism of accelerated bacterial clearance by lipopolysaccharide in CD14-deficient and Toll-like receptor 4-deficient mice. J Immunol 166(2):1075-8. PubMed: 11145687MGI: J:127072
- He RL; Zhou J; Hanson CZ; Chen J; Cheng N; Ye RD. 2009. Serum amyloid A induces G-CSF expression and neutrophilia via Toll-like receptor 2. Blood 113(2):429-37. PubMed: 18952897MGI: J:144859
- He S; Liang Y; Shao F; Wang X. 2011. Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway. Proc Natl Acad Sci U S A 108(50):20054-9. PubMed: 22123964MGI: J:180434
- Heimesaat MM; Fischer A; Jahn HK; Niebergall J; Freudenberg M; Blaut M; Liesenfeld O; Schumann RR; Gobel UB; Bereswill S. 2007. Exacerbation of murine ileitis by Toll-like receptor 4 mediated sensing of lipopolysaccharide from commensal Escherichia coli. Gut 56(7):941-8. PubMed: 17255219MGI: J:131231
- Heimesaat MM; Fischer A; Siegmund B; Kupz A; Niebergall J; Fuchs D; Jahn HK; Freudenberg M; Loddenkemper C; Batra A; Lehr HA; Liesenfeld O; Blaut M; Gobel UB; Schumann RR; Bereswill S. 2007. Shift towards pro-inflammatory intestinal bacteria aggravates acute murine colitis via Toll-like receptors 2 and 4. PLoS One 2(7):e662. PubMed: 17653282MGI: J:129318
- Henao-Mejia J; Elinav E; Jin C; Hao L; Mehal WZ; Strowig T; Thaiss CA; Kau AL; Eisenbarth SC; Jurczak MJ; Camporez JP; Shulman GI; Gordon JI; Hoffman HM; Flavell RA. 2012. Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature 482(7384):179-85. PubMed: 22297845MGI: J:181354
- Hergott CB; Roche AM; Tamashiro E; Clarke TB; Bailey AG; Laughlin A; Bushman FD; Weiser JN. 2016. Peptidoglycan from the gut microbiota governs the lifespan of circulating phagocytes at homeostasis. Blood 127(20):2460-71. PubMed: 26989200MGI: J:233078
- Hua F; Ha T; Ma J; Li Y; Kelley J; Gao X; Browder IW; Kao RL; Williams DL; Li C. 2007. Protection against myocardial ischemia/reperfusion injury in TLR4-deficient mice is mediated through a phosphoinositide 3-kinase-dependent mechanism. J Immunol 178(11):7317-24. PubMed: 17513782MGI: J:147828
- Hua F; Ma J; Ha T; Kelley JL; Kao RL; Schweitzer JB; Kalbfleisch JH; Williams DL; Li C. 2009. Differential roles of TLR2 and TLR4 in acute focal cerebral ischemia/reperfusion injury in mice. Brain Res 1262:100-8. PubMed: 19401158MGI: J:148091
- Hua F; Ma J; Ha T; Xia Y; Kelley J; Williams DL; Kao RL; Browder IW; Schweitzer JB; Kalbfleisch JH; Li C. 2007. Activation of Toll-like receptor 4 signaling contributes to hippocampal neuronal death following global cerebral ischemia/reperfusion. J Neuroimmunol 190(1-2):101-11. PubMed: 17884182MGI: J:129001
- Ince MN; Elliott DE; Setiawan T; Blum A; Metwali A; Wang Y; Urban JF Jr; Weinstock JV. 2006. Heligmosomoides polygyrus induces TLR4 on murine mucosal T cells that produce TGFbeta after lipopolysaccharide stimulation. J Immunol 176(2):726-9. PubMed: 16393954MGI: J:126606
- Iori V; Maroso M; Rizzi M; Iyer AM; Vertemara R; Carli M; Agresti A; Antonelli A; Bianchi ME; Aronica E; Ravizza T; Vezzani A. 2013. Receptor for Advanced Glycation Endproducts is upregulated in temporal lobe epilepsy and contributes to experimental seizures. Neurobiol Dis 58C:102-114. PubMed: 23523633MGI: J:197910
- Janelsins BM; Lu M; Datta SK. 2014. Altered inactivation of commensal LPS due to acyloxyacyl hydrolase deficiency in colonic dendritic cells impairs mucosal Th17 immunity. Proc Natl Acad Sci U S A 111(1):373-8. PubMed: 24344308MGI: J:206287
- Janova H; Bottcher C; Holtman IR; Regen T; van Rossum D; Gotz A; Ernst AS; Fritsche C; Gertig U; Saiepour N; Gronke K; Wrzos C; Ribes S; Rolfes S; Weinstein J; Ehrenreich H; Pukrop T; Kopatz J; Stadelmann C; Salinas-Riester G; Weber MS; Prinz M; Bruck W; Eggen BJ; Boddeke HW; Priller J; Hanisch UK. 2016. CD14 is a key organizer of microglial responses to CNS infection and injury. Glia 64(4):635-49. PubMed: 26683584MGI: J:229486
- Jawdat DM; Rowden G; Marshall JS. 2006. Mast cells have a pivotal role in TNF-independent lymph node hypertrophy and the mobilization of Langerhans cells in response to bacterial peptidoglycan. J Immunol 177(3):1755-62. PubMed: 16849485MGI: J:137976
- Jayachandran M; Brunn GJ; Karnicki K; Miller RS; Owen WG; Miller VM. 2007. In vivo effects of lipopolysaccharide and TLR4 on platelet production and activity: implications for thrombotic risk. J Appl Physiol 102(1):429-33. PubMed: 16916914MGI: J:135961
- John B; Crispe IN. 2005. TLR-4 regulates CD8+ T cell trapping in the liver. J Immunol 175(3):1643-50. PubMed: 16034104MGI: J:107284
- Johnson GB; Riggs BL; Platt JL. 2004. A genetic basis for the 'Adonis' phenotype of low adiposity and strong bones. FASEB J 18(11):1282-4. PubMed: 15208271MGI: J:118467
- Joosten LA; Koenders MI; Smeets RL; Heuvelmans-Jacobs M; Helsen MM; Takeda K; Akira S; Lubberts E; van de Loo FA; van den Berg WB. 2003. Toll-like receptor 2 pathway drives streptococcal cell wall-induced joint inflammation: critical role of myeloid differentiation factor 88. J Immunol 171(11):6145-53. PubMed: 14634130MGI: J:119063
- Jung ID; Jeong SK; Lee CM; Noh KT; Heo DR; Shin YK; Yun CH; Koh WJ; Akira S; Whang J; Kim HJ; Park WS; Shin SJ; Park YM. 2011. Enhanced Efficacy of Therapeutic Cancer Vaccines Produced by Co-Treatment with Mycobacterium tuberculosis Heparin-Binding Hemagglutinin, a Novel TLR4 Agonist. Cancer Res 71(8):2858-2870. PubMed: 21368092MGI: J:170995
- Jurewicz M; Takakura A; Augello A; Naini SM; Ichimura T; Zandi-Nejad K; Abdi R. 2010. Ischemic injury enhances dendritic cell immunogenicity via TLR4 and NF-kappa B activation. J Immunol 184(6):2939-48. PubMed: 20164431MGI: J:160107
- Kaiser P; Regoes RR; Dolowschiak T; Wotzka SY; Lengefeld J; Slack E; Grant AJ; Ackermann M; Hardt WD. 2014. Cecum lymph node dendritic cells harbor slow-growing bacteria phenotypically tolerant to antibiotic treatment. PLoS Biol 12(2):e1001793. PubMed: 24558351MGI: J:208411
- Kalis C; Kanzler B; Lembo A; Poltorak A; Galanos C; Freudenberg MA. 2003. Toll-like receptor 4 expression levels determine the degree of LPS-susceptibility in mice. Eur J Immunol 33(3):798-805. PubMed: 12616500MGI: J:82413
- Kane CM; Jung E; Pearce EJ. 2008. Schistosoma mansoni egg antigen-mediated modulation of Toll-like receptor (TLR)-induced activation occurs independently of TLR2, TLR4, and MyD88. Infect Immun 76(12):5754-9. PubMed: 18824534MGI: J:143320
- Kawamoto EM; Cutler RG; Rothman SM; Mattson MP; Camandola S. 2014. TLR4-dependent metabolic changes are associated with cognitive impairment in an animal model of type 1 diabetes. Biochem Biophys Res Commun 443(2):731-7. PubMed: 24342620MGI: J:211853
- Kelkka T; Hultqvist M; Nandakumar KS; Holmdahl R. 2012. Enhancement of Antibody-Induced Arthritis via Toll-Like Receptor 2 Stimulation Is Regulated by Granulocyte Reactive Oxygen Species. Am J Pathol 181(1):141-50. PubMed: 22642907MGI: J:185524
- Kelly MM; McNagny K; Williams DL; van Rooijen N; Maxwell L; Gwozd C; Mody CH; Kubes P. 2008. The lung responds to zymosan in a unique manner independent of toll-like receptors, complement, and dectin-1. Am J Respir Cell Mol Biol 38(2):227-38. PubMed: 17717323MGI: J:146394
- Kezic J; Taylor S; Gupta S; Planck SR; Rosenzweig HL; Rosenbaum JT. 2011. Endotoxin-induced uveitis is primarily dependent on radiation-resistant cells and on MyD88 but not TRIF. J Leukoc Biol 90(2):305-11. PubMed: 21610198MGI: J:175728
- Khan MA; Ma C; Knodler LA; Valdez Y; Rosenberger CM; Deng W; Finlay BB; Vallance BA. 2006. Toll-like receptor 4 contributes to colitis development but not to host defense during Citrobacter rodentium infection in mice. Infect Immun 74(5):2522-36. PubMed: 16622187MGI: J:108095
- Kim K; Sohn H; Kim JS; Choi HG; Byun EH; Lee KI; Shin SJ; Song CH; Park JK; Kim HJ. 2012. Mycobacterium tuberculosis Rv0652 stimulates production of tumour necrosis factor and monocytes chemoattractant protein-1 in macrophages through the Toll-like receptor 4 pathway. Immunology 136(2):231-40. PubMed: 22385341MGI: J:185378
- Kim KA; Gu W; Lee IA; Joh EH; Kim DH. 2012. High fat diet-induced gut microbiota exacerbates inflammation and obesity in mice via the TLR4 signaling pathway. PLoS One 7(10):e47713. PubMed: 23091640MGI: J:192184
- Kropf P; Freudenberg MA; Modolell M; Price HP; Herath S; Antoniazi S; Galanos C; Smith DF; Muller I. 2004. Toll-like receptor 4 contributes to efficient control of infection with the protozoan parasite Leishmania major. Infect Immun 72(4):1920-8. PubMed: 15039311MGI: J:88996
- Kropf P; Freudenberg N; Kalis C; Modolell M; Herath S; Galanos C; Freudenberg M; Muller I. 2004. Infection of C57BL/10ScCr and C57BL/10ScNCr mice with Leishmania major reveals a role for Toll-like receptor 4 in the control of parasite replication. J Leukoc Biol 76(1):48-57. PubMed: 15039466MGI: J:91014
- Kundu P; Ling TW; Korecka A; Li Y; D'Arienzo R; Bunte RM; Berger T; Arulampalam V; Chambon P; Mak TW; Wahli W; Pettersson S. 2014. Absence of intestinal PPARgamma aggravates acute infectious colitis in mice through a lipocalin-2-dependent pathway. PLoS Pathog 10(1):e1003887. PubMed: 24465207MGI: J:242057
- Lange S; Delbro DS; Jennische E; Mattsby-Baltzer I. 1996. The role of the Lps gene in experimental ulcerative colitis in mice. APMIS 104(11):823-33. PubMed: 8982246MGI: J:37271
- Lebeis SL; Bommarius B; Parkos CA; Sherman MA; Kalman D. 2007. TLR signaling mediated by MyD88 is required for a protective innate immune response by neutrophils to Citrobacter rodentium. J Immunol 179(1):566-77. PubMed: 17579078MGI: J:149408
- Lee CC; Kung JT. 2012. Marginal zone B cell is a major source of Il-10 in Listeria monocytogenes susceptibility. J Immunol 189(7):3319-27. PubMed: 22933629MGI: J:190348
- Lee JJ; Wang PW; Yang IH; Huang HM; Chang CS; Wu CL; Chuang JH. 2015. High-fat diet induces toll-like receptor 4-dependent macrophage/microglial cell activation and retinal impairment. Invest Ophthalmol Vis Sci 56(5):3041-50. PubMed: 26024088MGI: J:230965
- Lee JS; Frevert CW; Matute-Bello G; Wurfel MM; Wong VA; Lin SM; Ruzinski J; Mongovin S; Goodman RB; Martin TR. 2005. TLR-4 pathway mediates the inflammatory response but not bacterial elimination in E. coli pneumonia. Am J Physiol Lung Cell Mol Physiol 289(5):L731-8. PubMed: 16024722MGI: J:115440
- Lehmann CHK; Baranska A; Heidkamp GF; Heger L; Neubert K; Luhr JJ; Hoffmann A; Reimer KC; Bruckner C; Beck S; Seeling M; Kiessling M; Soulat D; Krug AB; Ravetch JV; Leusen JHW; Nimmerjahn F; Dudziak D. 2017. DC subset-specific induction of T cell responses upon antigen uptake via Fcgamma receptors in vivo. J Exp Med 214(5):1509-1528. PubMed: 28389502MGI: J:242013
- Letran SE; Lee SJ; Atif SM; Uematsu S; Akira S; McSorley SJ. 2011. TLR5 functions as an endocytic receptor to enhance flagellin-specific adaptive immunity. Eur J Immunol 41(1):29-38. PubMed: 21182074MGI: J:174661
- Li M; Feng B; Wang L; Guo S; Zhang P; Gong J; Zhang Y; Zheng A; Li H. 2015. Tollip is a critical mediator of cerebral ischaemia-reperfusion injury. J Pathol :. PubMed: 26011492MGI: J:225605
- Li S; Sun Y; Liang CP; Thorp EB; Han S; Jehle AW; Saraswathi V; Pridgen B; Kanter JE; Li R; Welch CL; Hasty AH; Bornfeldt KE; Breslow JL; Tabas I; Tall AR. 2009. Defective phagocytosis of apoptotic cells by macrophages in atherosclerotic lesions of ob/ob mice and reversal by a fish oil diet. Circ Res 105(11):1072-82. PubMed: 19834009MGI: J:170144
- Li Y; Si R; Feng Y; Chen HH; Zou L; Wang E; Zhang M; Warren HS; Sosnovik DE; Chao W. 2011. Myocardial ischemia activates an injurious innate immune signaling via cardiac heat shock protein 60 and Toll-like receptor 4. J Biol Chem 286(36):31308-19. PubMed: 21775438MGI: J:176610
- Lim H; Kim D; Lee SJ. 2013. Toll-like receptor 2 mediates peripheral nerve injury-induced NADPH oxidase 2 expression in spinal cord microglia. J Biol Chem 288(11):7572-9. PubMed: 23386616MGI: J:197856
- Lippai D; Bala S; Petrasek J; Csak T; Levin I; Kurt-Jones EA; Szabo G. 2013. Alcohol-induced IL-1beta in the brain is mediated by NLRP3/ASC inflammasome activation that amplifies neuroinflammation. J Leukoc Biol 94(1):171-82. PubMed: 23625200MGI: J:201853
- Liu C; Gao F; Li B; Mitchel RE; Liu X; Lin J; Zhao L; Cai J. 2011. TLR4 knockout protects mice from radiation-induced thymic lymphoma by downregulation of IL6 and miR-21. Leukemia 25(9):1516-9. PubMed: 21617699MGI: J:175727
- Lorne E; Zmijewski JW; Zhao X; Liu G; Tsuruta Y; Park YJ; Dupont H; Abraham E. 2008. Role of extracellular superoxide in neutrophil activation: interactions between xanthine oxidase and TLR4 induce proinflammatory cytokine production. Am J Physiol Cell Physiol 294(4):C985-93. PubMed: 18287332MGI: J:136585
- Lu M; Munford RS. 2011. The transport and inactivation kinetics of bacterial lipopolysaccharide influence its immunological potency in vivo. J Immunol 187(6):3314-20. PubMed: 21849675MGI: J:179236
- Lu M; Varley AW; Munford RS. 2013. Persistently active microbial molecules prolong innate immune tolerance in vivo. PLoS Pathog 9(5):e1003339. PubMed: 23675296MGI: J:213407
- Lukewich MK; Lomax AE. 2013. Toll-like receptor 4 activation reduces adrenal chromaffin cell excitability through a nuclear factor-kappaB-dependent pathway. Endocrinology 154(1):351-62. PubMed: 23125310MGI: J:192834
- Mandell L; Moran AP; Cocchiarella A; Houghton J; Taylor N; Fox JG; Wang TC; Kurt-Jones EA. 2004. Intact gram-negative Helicobacter pylori, Helicobacter felis, and Helicobacter hepaticus bacteria activate innate immunity via toll-like receptor 2 but not toll-like receptor 4. Infect Immun 72(11):6446-54. PubMed: 15501775MGI: J:93282
- Mann PB; Elder KD; Kennett MJ; Harvill ET. 2004. Toll-like receptor 4-dependent early elicited tumor necrosis factor alpha expression is critical for innate host defense against Bordetella bronchiseptica. Infect Immun 72(11):6650-8. PubMed: 15501798MGI: J:93263
- Mann PB; Kennett MJ; Harvill ET. 2004. Toll-like receptor 4 is critical to innate host defense in a murine model of bordetellosis. J Infect Dis 189(5):833-6. PubMed: 14976600MGI: J:88587
- Mann PB; Wolfe D; Latz E; Golenbock D; Preston A; Harvill ET. 2005. Comparative toll-like receptor 4-mediated innate host defense to Bordetella infection. Infect Immun 73(12):8144-52. PubMed: 16299309MGI: J:104298
- Martin SF; Dudda JC; Bachtanian E; Lembo A; Liller S; Durr C; Heimesaat MM; Bereswill S; Fejer G; Vassileva R; Jakob T; Freudenberg N; Termeer CC; Johner C; Galanos C; Freudenberg MA. 2008. Toll-like receptor and IL-12 signaling control susceptibility to contact hypersensitivity. J Exp Med 205(9):2151-62. PubMed: 18725520MGI: J:138813
- Meng D; Zhu W; Ganguli K; Shi HN; Walker WA. 2016. Anti-inflammatory effects of Bifidobacterium longum subsp infantis secretions on fetal human enterocytes are mediated by TLR-4 receptors. Am J Physiol Gastrointest Liver Physiol 311(4):G744-G753. PubMed: 27562058MGI: J:240444
- Meng J; Yu H; Ma J; Wang J; Banerjee S; Charboneau R; Barke RA; Roy S. 2013. Morphine induces bacterial translocation in mice by compromising intestinal barrier function in a TLR-dependent manner. PLoS One 8(1):e54040. PubMed: 23349783MGI: J:195846
- Merlin T; Sing A; Nielsen PJ; Galanos C; Freudenberg MA. 2001. Inherited IL-12 unresponsiveness contributes to the high LPS resistance of the lps(d) C57BL/10ScCr mouse J Immunol 166(1):566-73. PubMed: 11123338MGI: J:66394
- Minguet S; Dopfer EP; Pollmer C; Freudenberg MA; Galanos C; Reth M; Huber M; Schamel WW. 2008. Enhanced B-cell activation mediated by TLR4 and BCR crosstalk. Eur J Immunol 38(9):2475-87. PubMed: 18819072MGI: J:140162
- Moraga A; Pradillo JM; Cuartero MI; Hernandez-Jimenez M; Oses M; Moro MA; Lizasoain I. 2014. Toll-like receptor 4 modulates cell migration and cortical neurogenesis after focal cerebral ischemia. FASEB J 28(11):4710-8. PubMed: 25063846MGI: J:217717
- Moses T; Wagner L; Fleming SD. 2009. TLR4-mediated Cox-2 expression increases intestinal ischemia/reperfusion-induced damage. J Leukoc Biol 86(4):971-80. PubMed: 19564573MGI: J:153441
- Mullaly SC; Kubes P. 2006. The role of TLR2 in vivo following challenge with Staphylococcus aureus and prototypic ligands. J Immunol 177(11):8154-63. PubMed: 17114491MGI: J:140680
- Mullaly SC; Kubes P. 2007. Mast cell-expressed complement receptor, not TLR2, is the main detector of zymosan in peritonitis. Eur J Immunol 37(1):224-34. PubMed: 17154261MGI: J:117071
- Muller I; Freudenberg M; Kropf P; Kiderlen AF; Galanos C. 1997. Leishmania major infection in C57BL/10 mice differing at the Lps locus: a new non-healing phenotype. Med Microbiol Immunol (Berl) 186(2-3):75-81. PubMed: 9403834MGI: J:44519
- Nagarajan UM; Ojcius DM; Stahl L; Rank RG; Darville T. 2005. Chlamydia trachomatis induces expression of IFN-gamma-inducible protein 10 and IFN-beta independent of TLR2 and TLR4, but largely dependent on MyD88. J Immunol 175(1):450-60. PubMed: 15972679MGI: J:100592
- Nagarajan UM; Sikes J; Prantner D; Andrews CW Jr; Frazer L; Goodwin A; Snowden JN; Darville T. 2011. MyD88 deficiency leads to decreased NK cell gamma interferon production and T cell recruitment during Chlamydia muridarum genital tract infection, but a predominant Th1 response and enhanced monocytic inflammation are associated with infection resolution. Infect Immun 79(1):486-98. PubMed: 21078858MGI: J:167051
- Nagareddy PR; Kraakman M; Masters SL; Stirzaker RA; Gorman DJ; Grant RW; Dragoljevic D; Hong ES; Abdel-Latif A; Smyth SS; Choi SH; Korner J; Bornfeldt KE; Fisher EA; Dixit VD; Tall AR; Goldberg IJ; Murphy AJ. 2014. Adipose tissue macrophages promote myelopoiesis and monocytosis in obesity. Cell Metab 19(5):821-35. PubMed: 24807222MGI: J:215261
- Necela BM; Su W; Thompson EA. 2008. Toll-like receptor 4 mediates cross-talk between peroxisome proliferator-activated receptor gamma and nuclear factor-kappaB in macrophages. Immunology 125(3):344-58. PubMed: 18422969MGI: J:144451
- Netea MG; Kullberg BJ; Jacobs LE; Verver-Jansen TJ; van der Ven-Jongekrijg J; Galama JM; Stalenhoef AF; Dinarello CA; Van der Meer JW. 2004. Chlamydia pneumoniae stimulates IFN-gamma synthesis through MyD88-dependent, TLR2- and TLR4-independent induction of IL-18 release. J Immunol 173(2):1477-82. PubMed: 15240744MGI: J:91941
- Norseen J; Hosooka T; Hammarstedt A; Yore MM; Kant S; Aryal P; Kiernan UA; Phillips DA; Maruyama H; Kraus BJ; Usheva A; Davis RJ; Smith U; Kahn BB. 2012. Retinol-binding protein 4 inhibits insulin signaling in adipocytes by inducing proinflammatory cytokines in macrophages through a c-Jun N-terminal kinase- and toll-like receptor 4-dependent and retinol-independent mechanism. Mol Cell Biol 32(10):2010-9. PubMed: 22431523MGI: J:185736
- Nunez NG; Andreani V; Crespo MI; Nocera DA; Breser ML; Moron G; Dejager L; Libert C; Rivero V; Maccioni M. 2012. IFNbeta produced by TLR4-activated tumor cells is involved in improving the antitumoral immune response. Cancer Res 72(3):592-603. PubMed: 22139376MGI: J:181135
- Nussbaum G; Ben-Adi S; Genzler T; Sela M; Rosen G. 2009. Involvement of Toll-like receptors 2 and 4 in the innate immune response to Treponema denticola and its outer sheath components. Infect Immun 77(9):3939-47. PubMed: 19596768MGI: J:152226
- Ochi A; Nguyen AH; Bedrosian AS; Mushlin HM; Zarbakhsh S; Barilla R; Zambirinis CP; Fallon NC; Rehman A; Pylayeva-Gupta Y; Badar S; Hajdu CH; Frey AB; Bar-Sagi D; Miller G. 2012. MyD88 inhibition amplifies dendritic cell capacity to promote pancreatic carcinogenesis via Th2 cells. J Exp Med 209(9):1671-87. PubMed: 22908323MGI: J:191814
- Okun E; Barak B; Saada-Madar R; Rothman SM; Griffioen KJ; Roberts N; Castro K; Mughal MR; Pita MA; Stranahan AM; Arumugam TV; Mattson MP. 2012. Evidence for a developmental role for TLR4 in learning and memory. PLoS One 7(10):e47522. PubMed: 23071817MGI: J:192223
- Oyama J; Blais C Jr; Liu X; Pu M; Kobzik L; Kelly RA; Bourcier T. 2004. Reduced myocardial ischemia-reperfusion injury in toll-like receptor 4-deficient mice. Circulation 109(6):784-9. PubMed: 14970116MGI: J:102150
- Palliser D; Huang Q; Hacohen N; Lamontagne SP; Guillen E; Young RA; Eisen HN. 2004. A role for Toll-like receptor 4 in dendritic cell activation and cytolytic CD8+ T cell differentiation in response to a recombinant heat shock fusion protein. J Immunol 172(5):2885-93. PubMed: 14978090MGI: J:88229
- Pfannes SD; Muller B; Korner S; Bessler WG; Hoffmann P. 2001. Induction of soluble antitumoral mediators by synthetic analogues of bacterial lipoprotein in bone marrow-derived macrophages from LPS-responder and -nonresponder mice. J Leukoc Biol 69(4):590-7. PubMed: 11310845MGI: J:68625
- Poltorak A; Merlin T; Nielsen PJ; Sandra O; Smirnova I; Schupp I; Boehm T; Galanos C; Freudenberg MA. 2001. A point mutation in the il-12rbeta2 gene underlies the il-12 unresponsiveness of lps-defective c57bl/10sccr mice. J Immunol 167(4):2106-11. PubMed: 11489994MGI: J:70821
- Poltorak A; Smirnova I; Clisch R; Beutler B. 2000. Limits of a deletion spanning Tlr4 in C57BL/10ScCr mice. J Endotoxin Res 6(1):51-6. PubMed: 11061032MGI: J:122203
- Pope MR; Hoffman SM; Tomlinson S; Fleming SD. 2010. Complement regulates TLR4-mediated inflammatory responses during intestinal ischemia reperfusion. Mol Immunol 48(1-3):356-64. PubMed: 20800895MGI: J:167099
- Power MR; Marshall JS; Yamamoto M; Akira S; Lin TJ. 2006. The myeloid differentiation factor 88 is dispensable for the development of a delayed host response to Pseudomonas aeruginosa lung infection in mice. Clin Exp Immunol 146(2):323-9. PubMed: 17034585MGI: J:113568
- Prantner D; Darville T; Nagarajan UM. 2010. Stimulator of IFN gene is critical for induction of IFN-beta during Chlamydia muridarum infection. J Immunol 184(5):2551-60. PubMed: 20107183MGI: J:159659
- Quintana FJ; Solomon A; Cohen IR; Nussbaum G. 2008. Induction of IgG3 to LPS via Toll-like receptor 4 co-stimulation. PLoS One 3(10):e3509. PubMed: 18946502MGI: J:144630
- Qureshi ST; Lariviere L; Leveque G; Clermont S; Moore KJ; Gros P ; Malo D. 1999. Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4) [see comments] J Exp Med 189(4):615-25. PubMed: 9989976MGI: J:53343
- Ren M; Li R; Luo M; Chen N; Deng X; Yan K; Zeng M; Wu J. 2014. Endothelial cells but not platelets are the major source of Toll-like receptor 4 in the arterial thrombosis and tissue factor expression in mice. Am J Physiol Regul Integr Comp Physiol 307(7):R901-7. PubMed: 25275013MGI: J:223885
- Riad A; Jager S; Sobirey M; Escher F; Yaulema-Riss A; Westermann D; Karatas A; Heimesaat MM; Bereswill S; Dragun D; Pauschinger M; Schultheiss HP; Tschope C. 2008. Toll-like receptor-4 modulates survival by induction of left ventricular remodeling after myocardial infarction in mice. J Immunol 180(10):6954-61. PubMed: 18453617MGI: J:134865
- Rico MA; Infantes S; Ramos M; Trento A; Johnstone C; Melero JA; Del Val M; Lopez D. 2010. TLR4-independent upregulation of activation markers in mouse B lymphocytes infected by HRSV. Mol Immunol 47(9):1802-7. PubMed: 20362337MGI: J:160628
- Riddell JR; Bshara W; Moser MT; Spernyak JA; Foster BA; Gollnick SO. 2011. Peroxiredoxin 1 Controls Prostate Cancer Growth through Toll-Like Receptor 4-Dependent Regulation of Tumor Vasculature. Cancer Res 71(5):1637-46. PubMed: 21343392MGI: J:169529
- Riddell JR; Wang XY; Minderman H; Gollnick SO. 2010. Peroxiredoxin 1 stimulates secretion of proinflammatory cytokines by binding to TLR4. J Immunol 184(2):1022-30. PubMed: 20018613MGI: J:159404
- Riva M; Kallberg E; Bjork P; Hancz D; Vogl T; Roth J; Ivars F; Leanderson T. 2012. Induction of nuclear factor-kappaB responses by the S100A9 protein is Toll-like receptor-4-dependent. Immunology 137(2):172-82. PubMed: 22804476MGI: J:189636
- Rivas MN; Koh YT; Chen A; Nguyen A; Lee YH; Lawson G; Chatila TA. 2012. MyD88 is critically involved in immune tolerance breakdown at environmental interfaces of Foxp3-deficient mice. J Clin Invest 122(5):1933-47. PubMed: 22466646MGI: J:184544
- Robblee MM; Kim CC; Porter Abate J; Valdearcos M; Sandlund KL; Shenoy MK; Volmer R; Iwawaki T; Koliwad SK. 2016. Saturated Fatty Acids Engage an IRE1alpha-Dependent Pathway to Activate the NLRP3 Inflammasome in Myeloid Cells. Cell Rep 14(11):2611-23. PubMed: 26971994MGI: J:234721
- Rolls A; Shechter R; London A; Ziv Y; Ronen A; Levy R; Schwartz M. 2007. Toll-like receptors modulate adult hippocampal neurogenesis. Nat Cell Biol 9(9):1081-8. PubMed: 17704767MGI: J:129957
- Rosen GD; Azoulay NG; Griffin EG; Newbury A; Koganti L; Fujisaki N; Takahashi E; Grant PE; Truong DT; Fitch RH; Lu L; Williams RW. 2012. Bilateral Subcortical Heterotopia with Partial Callosal Agenesis in a Mouse Mutant. Cereb Cortex :. PubMed: 22455839MGI: J:184128
- Rumbaut RE; Bellera RV; Randhawa JK; Shrimpton CN; Dasgupta SK; Dong JF; Burns AR. 2006. Endotoxin enhances microvascular thrombosis in mouse cremaster venules via a TLR4-dependent, neutrophil-independent mechanism. Am J Physiol Heart Circ Physiol 290(4):H1671-9. PubMed: 16284241MGI: J:108441
- Saberi M; Woods NB; de Luca C; Schenk S; Lu JC; Bandyopadhyay G; Verma IM; Olefsky JM. 2009. Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice. Cell Metab 10(5):419-29. PubMed: 19883619MGI: J:155431
- Scheeren FA; Kuo AH; van Weele LJ; Cai S; Glykofridis I; Sikandar SS; Zabala M; Qian D; Lam JS; Johnston D; Volkmer JP; Sahoo D; van de Rijn M; Dirbas FM; Somlo G; Kalisky T; Rothenberg ME; Quake SR; Clarke MF. 2014. A cell-intrinsic role for TLR2-MYD88 in intestinal and breast epithelia and oncogenesis. Nat Cell Biol 16(12):1238-48. PubMed: 25362351MGI: J:217693
- Schmidt M; Raghavan B; Muller V; Vogl T; Fejer G; Tchaptchet S; Keck S; Kalis C; Nielsen PJ; Galanos C; Roth J; Skerra A; Martin SF; Freudenberg MA; Goebeler M. 2010. Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel. Nat Immunol 11(9):814-9. PubMed: 20711192MGI: J:163916
- Schuettpelz LG; Borgerding JN; Christopher MJ; Gopalan PK; Romine MP; Herman AC; Woloszynek JR; Greenbaum AM; Link DC. 2014. G-CSF regulates hematopoietic stem cell activity, in part, through activation of Toll-like receptor signaling. Leukemia 28(9):1851-60. PubMed: 24518205MGI: J:213449
- Schulthess FT ; Paroni F ; Sauter NS ; Shu L ; Ribaux P ; Haataja L ; Strieter RM ; Oberholzer J ; King CC ; Maedler K. 2009. CXCL10 impairs beta cell function and viability in diabetes through TLR4 signaling. Cell Metab 9(2):125-39. PubMed: 19187771MGI: J:146651
- Scott MJ; Billiar TR. 2008. Beta2-integrin-induced p38 MAPK activation is a key mediator in the CD14/TLR4/MD2-dependent uptake of lipopolysaccharide by hepatocytes. J Biol Chem 283(43):29433-46. PubMed: 18701460MGI: J:142561
- Seimon TA; Nadolski MJ; Liao X; Magallon J; Nguyen M; Feric NT; Koschinsky ML; Harkewicz R; Witztum JL; Tsimikas S; Golenbock D; Moore KJ; Tabas I. 2010. Atherogenic lipids and lipoproteins trigger CD36-TLR2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stress. Cell Metab 12(5):467-82. PubMed: 21035758MGI: J:167910
- Seimon TA; Obstfeld A; Moore KJ; Golenbock DT; Tabas I. 2006. Combinatorial pattern recognition receptor signaling alters the balance of life and death in macrophages. Proc Natl Acad Sci U S A 103(52):19794-9. PubMed: 17167049MGI: J:118240
- Shakya AK; Kumar A; Klaczkowska D; Hultqvist M; Hagenow K; Holmdahl R; Nandakumar KS. 2011. Collagen Type II and a Thermo-Responsive Polymer of N-Isopropylacrylamide Induce Arthritis Independent of Toll-Like Receptors A Strong Influence by Major Histocompatibility Complex Class II and Ncf1 Genes. Am J Pathol 179(5):2490-500. PubMed: 21933654MGI: J:177359
- Shao B; Lu M; Katz SC; Varley AW; Hardwick J; Rogers TE; Ojogun N; Rockey DC; Dematteo RP; Munford RS. 2007. A host lipase detoxifies bacterial lipopolysaccharides in the liver and spleen. J Biol Chem 282(18):13726-35. PubMed: 17322564MGI: J:121874
- Shechter R; Ronen A; Rolls A; London A; Bakalash S; Young MJ; Schwartz M. 2008. Toll-like receptor 4 restricts retinal progenitor cell proliferation. J Cell Biol 183(3):393-400. PubMed: 18981228MGI: J:141070
- Shen XD; Ke B; Zhai Y; Gao F; Busuttil RW; Cheng G; Kupiec-Weglinski JW. 2005. Toll-like receptor and heme oxygenase-1 signaling in hepatic ischemia/reperfusion injury. Am J Transplant 5(8):1793-800. PubMed: 15996225MGI: J:114368
- Shi X; Siggins RW; Stanford WL; Melvan JN; Basson MD; Zhang P. 2013. Toll-like receptor 4/stem cell antigen 1 signaling promotes hematopoietic precursor cell commitment to granulocyte development during the granulopoietic response to Escherichia coli bacteremia. Infect Immun 81(6):2197-205. PubMed: 23545304MGI: J:199520
- Simonaro CM; Ge Y; Eliyahu E; He X; Jepsen KJ; Schuchman EH. 2010. Involvement of the Toll-like receptor 4 pathway and use of TNF-alpha antagonists for treatment of the mucopolysaccharidoses. Proc Natl Acad Sci U S A 107(1):222-7. PubMed: 20018674MGI: J:156466
- Sing A; Roggenkamp A; Geiger AM; Heesemann J. 2002. Yersinia enterocolitica evasion of the host innate immune response by V antigen-induced IL-10 production of macrophages is abrogated in IL-10-deficient mice. J Immunol 168(3):1315-21. PubMed: 11801671MGI: J:127288
- So EY; Kim BS. 2009. Theiler's virus infection induces TLR3-dependent upregulation of TLR2 critical for proinflammatory cytokine production. Glia 57(11):1216-26. PubMed: 19191335MGI: J:156204
- Speer T; Rohrer L; Blyszczuk P; Shroff R; Kuschnerus K; Krankel N; Kania G; Zewinger S; Akhmedov A; Shi Y; Martin T; Perisa D; Winnik S; Muller MF; Sester U; Wernicke G; Jung A; Gutteck U; Eriksson U; Geisel J; Deanfield J; von Eckardstein A; Luscher TF;Fliser D; Bahlmann FH; Landmesser U. 2013. Abnormal High-Density Lipoprotein Induces Endothelial Dysfunction via Activation of Toll-like Receptor-2. Immunity 38(4):754-68. PubMed: 23477738MGI: J:196201
- St John AL; Abraham SN. 2009. Salmonella disrupts lymph node architecture by TLR4-mediated suppression of homeostatic chemokines. Nat Med 15(11):1259-65. PubMed: 19855398MGI: J:155766
- Stark RJ; Aghakasiri N; Rumbaut RE. 2012. Platelet-derived Toll-like receptor 4 (Tlr-4) is sufficient to promote microvascular thrombosis in endotoxemia. PLoS One 7(7):e41254. PubMed: 22911769MGI: J:189884
- Stefanova N; Fellner L; Reindl M; Masliah E; Poewe W; Wenning GK. 2011. Toll-Like Receptor 4 Promotes alpha-Synuclein Clearance and Survival of Nigral Dopaminergic Neurons. Am J Pathol 179(2):954-63. PubMed: 21801874MGI: J:174596
- Tagliabue A; McCoy JL; Herberman RB. 1978. Refractoriness to migration inhibitory factor of macrophages of LPS nonresponder mouse strains. J Immunol 121(4):1223-6. PubMed: 359704MGI: J:6043
- Tanga FY; Nutile-McMenemy N; Deleo JA. 2005. The CNS role of Toll-like receptor 4 in innate neuroimmunity and painful neuropathy. Proc Natl Acad Sci U S A 102(16):5856-61. PubMed: 15809417MGI: J:97819
- Tarallo V; Hirano Y; Gelfand BD; Dridi S; Kerur N; Kim Y; Cho WG; Kaneko H; Fowler BJ; Bogdanovich S; Albuquerque RJ; Hauswirth WW; Chiodo VA; Kugel JF; Goodrich JA; Ponicsan SL; Chaudhuri G; Murphy MP; Dunaief JL; Ambati BK; Ogura Y; Yoo JW; Lee DK; Provost P; Hinton DR; Nunez G; Baffi JZ; Kleinman ME; Ambati J. 2012. DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88. Cell 149(4):847-59. PubMed: 22541070MGI: J:186198
- Tchaptchet S; Gumenscheimer M; Kalis C; Freudenberg N; Holscher C; Kirschning CJ; Lamers M; Galanos C; Freudenberg MA. 2012. TLR9-dependent and independent pathways drive activation of the immune system by Propionibacterium acnes. PLoS One 7(6):e39155. PubMed: 22745710MGI: J:187937
- Thomas JA; Tsen MF; White DJ; Horton JW. 2002. TLR4 inactivation and rBPI(21) block burn-induced myocardial contractile dysfunction. Am J Physiol Heart Circ Physiol 283(4):H1645-55. PubMed: 12234819MGI: J:108049
- Tsukumo DM; Carvalho-Filho MA; Carvalheira JB; Prada PO; Hirabara SM; Schenka AA; Araujo EP; Vassallo J; Curi R; Velloso LA; Saad MJ. 2007. Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance. Diabetes 56(8):1986-98. PubMed: 17519423MGI: J:126488
- Uhl B; Vadlau Y; Zuchtriegel G; Nekolla K; Sharaf K; Gaertner F; Massberg S; Krombach F; Reichel CA. 2016. Aged neutrophils contribute to the first line of defense in the acute inflammatory response. Blood :. PubMed: 27609642MGI: J:239340
- Van Hove CL; Maes T; Joos GF; Tournoy KG. 2007. Prolonged inhaled allergen exposure can induce persistent tolerance. Am J Respir Cell Mol Biol 36(5):573-84. PubMed: 17218615MGI: J:136611
- Viriyakosol S; Fierer J; Brown GD; Kirkland TN. 2005. Innate immunity to the pathogenic fungus Coccidioides posadasii is dependent on Toll-like receptor 2 and Dectin-1. Infect Immun 73(3):1553-60. PubMed: 15731053MGI: J:96684
- Vogel SN; Johnson D; Perera PY; Medvedev A; Lariviere L; Qureshi ST ; Malo D. 1999. Cutting edge: functional characterization of the effect of the C3H/HeJ defect in mice that lack an Lpsn gene: in vivo evidence for a dominant negative mutation. J Immunol 162(10):5666-70. PubMed: 10229796MGI: J:54987
- Wang F; Yang Y. 2014. Identification of an antitumor immune response of polyhistidine through a toll-like receptor 4-dependent manner. Biochem Biophys Res Commun 453(1):148-52. PubMed: 25264106MGI: J:220079
- Wang L; Chen Q; Qi H; Wang C; Wang C; Zhang J; Dong L. 2016. Doxorubicin-Induced Systemic Inflammation Is Driven by Upregulation of Toll-Like Receptor TLR4 and Endotoxin Leakage. Cancer Res :. PubMed: 27680684MGI: J:237837
- Wang X; Ha T; Liu L; Zou J; Zhang X; Kalbfleisch J; Gao X; Williams D; Li C. 2013. Increased expression of microRNA-146a decreases myocardial ischaemia/reperfusion injury. Cardiovasc Res 97(3):432-42. PubMed: 23208587MGI: J:210282
- Wang X; Moser C; Louboutin JP; Lysenko ES; Weiner DJ; Weiser JN; Wilson JM. 2002. Toll-like receptor 4 mediates innate immune responses to Haemophilus influenzae infection in mouse lung. J Immunol 168(2):810-5. PubMed: 11777976MGI: J:73739
- Wang X; Zhou S; Chi Y; Wen X; Hoellwarth J; He L; Liu F; Wu C; Dhesi S; Zhao J; Hu W; Su C. 2009. CD4(+)CD25(+) Treg induction by an HSP60-derived peptide SJMHE1 from Schistosoma japonicum is TLR2 dependent. Eur J Immunol 39(11):3052-3065. PubMed: 19882655MGI: J:154162
- Ward MA; Pierre JF; Leal RF; Huang Y; Shogan B; Dalal SR; Weber CR; Leone VA; Musch MW; An GC; Rao MC; Rubin DT; Raffals LE; Antonopoulos DA; Sogin ML; Hyman NH; Alverdy JC; Chang EB. 2016. Insights into the pathogenesis of ulcerative colitis from a murine model of stasis-induced dysbiosis, colonic metaplasia, and genetic susceptibility. Am J Physiol Gastrointest Liver Physiol 310(11):G973-88. PubMed: 27079612MGI: J:235175
- Watanabe S; Kumazawa Y; Inoue J. 2013. Liposomal lipopolysaccharide initiates TRIF-dependent signaling pathway independent of CD14. PLoS One 8(4):e60078. PubMed: 23565187MGI: J:199946
- Watts BA 3rd; George T; Good DW. 2013. Lumen LPS inhibits HCOFormula absorption in the medullary thick ascending limb through TLR4-PI3K-Akt-mTOR-dependent inhibition of basolateral Na+/H+ exchange. Am J Physiol Renal Physiol 305(4):F451-62. PubMed: 23698118MGI: J:200847
- Watts BA 3rd; George T; Sherwood ER; Good DW. 2011. Basolateral LPS inhibits NHE3 and HCOFormula absorption through TLR4/MyD88-dependent ERK activation in medullary thick ascending limb. Am J Physiol Cell Physiol 301(6):C1296-306. PubMed: 21881005MGI: J:178333
- Wu J; Yan Z; Schwartz DE; Yu J; Malik AB; Hu G. 2013. Activation of NLRP3 Inflammasome in Alveolar Macrophages Contributes to Mechanical Stretch-Induced Lung Inflammation and Injury. J Immunol 190(7):3590-9. PubMed: 23436933MGI: J:194745
- Wuthrich M; Warner T; Klein BS. 2005. CD28 is required for optimal induction, but not maintenance, of vaccine-induced immunity to Blastomyces dermatitidis. Infect Immun 73(11):7436-41. PubMed: 16239544MGI: J:104194
- Xing EM; Wu S; Ponder KP. 2015. The effect of Tlr4 and/or C3 deficiency and of neonatal gene therapy on skeletal disease in mucopolysaccharidosis VII mice. Mol Genet Metab 114(2):209-16. PubMed: 25559179MGI: J:220353
- Xu H; Su Z; Wu J; Yang M; Penninger JM; Martin CM; Kvietys PR; Rui T. 2010. The alarmin cytokine, high mobility group box 1, is produced by viable cardiomyocytes and mediates the lipopolysaccharide-induced myocardial dysfunction via a TLR4/phosphatidylinositol 3-kinase gamma pathway. J Immunol 184(3):1492-8. PubMed: 20028656MGI: J:159535
- Xue J; Habtezion A. 2014. Carbon monoxide-based therapy ameliorates acute pancreatitis via TLR4 inhibition. J Clin Invest 124(1):437-47. PubMed: 24334457MGI: J:207616
- Yang IV; Alper S; Lackford B; Rutledge H; Warg LA; Burch LH; Schwartz DA. 2011. Novel regulators of the systemic response to lipopolysaccharide. Am J Respir Cell Mol Biol 45(2):393-402. PubMed: 21131441MGI: J:186820
- Yang X; Jiang X; Chen G; Xiao Y; Geng S; Kang C; Zhou T; Li Y; Guo X; Xiao H; Hou C; Wang R; Lin Z; Li X; Feng J; Ma Y; Shen B; Li Y; Han G. 2013. T Cell Ig Mucin-3 Promotes Homeostasis of Sepsis by Negatively Regulating the TLR Response. J Immunol 190(5):2068-79. PubMed: 23365080MGI: J:193459
- Yoshitaka T; Mukai T; Kittaka M; Alford LM; Masrani S; Ishida S; Yamaguchi K; Yamada M; Mizuno N; Olsen BR; Reichenberger EJ; Ueki Y. 2014. Enhanced TLR-MYD88 signaling stimulates autoinflammation in SH3BP2 cherubism mice and defines the etiology of cherubism. Cell Rep 8(6):1752-66. PubMed: 25220465MGI: J:218550
- Zhang LL; Gao CY; Fang CQ; Wang YJ; Gao D; Yao GE; Xiang J; Wang JZ; Li JC. 2011. PPARgamma attenuates intimal hyperplasia by inhibiting TLR4-mediated inflammation in vascular smooth muscle cells. Cardiovasc Res 92(3):484-93. PubMed: 21880694MGI: J:191553
- Zhang R; Li Y; Beck PL; McCafferty DM. 2007. Toll-like receptor 4 regulates colitis-associated adenocarcinoma development in interleukin-10-deficient (IL-10(-/-)) mice. Biochem Soc Trans 35(Pt 5):1375-6. PubMed: 17956355MGI: J:131228
- Zhang X; Shan P; Jiang G; Cohn L; Lee PJ. 2006. Toll-like receptor 4 deficiency causes pulmonary emphysema. J Clin Invest 116(11):3050-9. PubMed: 17053835MGI: J:114985
- Zhou H; Lapointe BM; Clark SR; Zbytnuik L; Kubes P. 2006. A requirement for microglial TLR4 in leukocyte recruitment into brain in response to lipopolysaccharide. J Immunol 177(11):8103-10. PubMed: 17114485MGI: J:140683
- Zhu X; Zhao H; Graveline AR; Buys ES; Schmidt U; Bloch KD; Rosenzweig A; Chao W. 2006. MyD88 and NOS2 are essential for toll-like receptor 4-mediated survival effect in cardiomyocytes. Am J Physiol Heart Circ Physiol 291(4):H1900-9. PubMed: 16648192MGI: J:116319
- Zola TA; Lysenko ES; Weiser JN. 2008. Mucosal clearance of capsule-expressing bacteria requires both TLR and nucleotide-binding oligomerization domain 1 signaling. J Immunol 181(11):7909-16. PubMed: 19017981MGI: J:142379