JAX Mouse Strain Datasheet - 007082

CByJ.129S(B6)-Tnf^tm1Gkl/J

Stock No:: 007082 |; TNFα^-

Cryo Recovery

Overview

Also Known As: TNFα^-

These tumor necrosis factor null knock-out mice may be useful in studies of susceptibility to parasitic and bacterial infection, endotoxin sensitivity and immune response.

Donating Investigator

Dr. George Kollias, Biomedical Sciences Research Centre Alexander Fleming

Genetic overview

Genetic Background	Generation

Tnf^tm1Gkl

Allele Type	Gene Symbol	Gene Name
Targeted (Null/Knockout)	Tnf	tumor necrosis factor

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Research Applications

Apoptosis Research
Cancer Research
Cardiovascular Research
Diabetes and Obesity Research
Endocrine Deficiency Research
Hematological Research
Immunology, Inflammation and Autoimmunity Research
Internal/Organ Research

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Base Price

Starting at:

$2,595.00 Domestic price Cryo Recovery

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Details

Detailed Description

Mice homozygous for the Tnf^tm1Gkl targeted mutation are viable and fertile. Development of both lymph nodes and Peyer's patches is normal, and homozygous mutant mice show no apparent phenotypic abnormalities. Homozygous mice completely lack splenic primary B cell follicles and cannot form organized follicular dendritic cell networks and germinal centers. TNF-deficient mice treated to induce skin carcinogenesis develop significantly less benign and malignant tumors than treated wildtype mice. Nonobese homozygous mutant mice show modest decreases in body weight, epididymal fat depot weight, and percent body fat (statistically significant in males at 28 weeks of age). Further characterization indicates that 28 week old male mutant mice display lower insulin, triglyceride, and leptin levels compared to wildtype controls. Characterization of TNF deficient homozygotes injected with gold-thioglucose (GTG) to induce hyperphagic obesity indicates that the presence of TNF does not affect the degree of obesity. However, fasting plasma glucose and insulin levels, and the insulin response to an oral glucose load were significantly decreased in obese TNF deficient mice compared to obese wildtype controls. These results indicate TNF plays a role in lipid and glucose metabolism but is not sufficient to completely eliminate hyperglycemia and hyperinsulinemia in this induced obesity model.

In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. This is the case for the strain above. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.

Development

The targeting vector was constructed by replacing with an MC1neopA cassette (Stratagene) the 438-bp Narl-BglII fragment containing 40 bp of the 5' UTR, all the coding region, including the ATG translation initiation codon, of the first exon and part of the first intron of the muTNFa gene. The construct was electroporated into 129S/SvEv-Gpi1^c-derived CCE embryonic stem (ES) cells. Correctly targeted ES cells were injected into C57BL/6 blastocysts. The resulting chimeric animals were crossed to C57BL/6 mice before being intercrossed to produce homozygotes. The mice were then backcrossed to BALB/cByJ for 5 generations (using a speed congenic protocol) before being made homozygous.

Control Suggestions

001026 BALB/cByJ

Additional Information

Considerations for Choosing Controls

Selected References

Pasparakis M; Alexopoulou L; Episkopou V; Kollias G. 1996. Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response [see comments] J Exp Med 184(4):1397-411. PubMed: 8879212 MGI: J:47673

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Genetics

Tnf^tm1Gkl

Allele Symbol: Tnf^tm1Gkl

Allele Name	targeted mutation 1, George Kollias
Allele Type	Targeted (Null/Knockout)
Allele Synonym(s)	TNF-; TNFKO; TNFalpha KO; TNFalpha^-; Tnf-alpha-; Tnf0
Gene Symbol and Name	Tnf, tumor necrosis factor
Gene Synonym(s)	DIF; RATTNF; TNF alpha; TNF-alpha; TNFA; TNFSF2; TNFalpha; TNLG1F; Tnfa; Tnfa; Tnfsf1a; tumor necrosis factor, alpha; tumor necrosis factor-alpha
Strain of Origin	129S/SvEv-Gpi1
Chromosome	17
Molecular Note	Replacement of 40 bp of the 5' UTR, all the coding region, including the ATG translation initiation codon, of the first exon and part of the first intron with MC1neopA cassette. Northern blot analysis of LPS stimulated macrophages confirmed disruption of Tnf mRNA expression.
Mutations Made By	Dr. George Kollias, Biomedical Sciences Research Centre Alexander Fleming

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Apoptosis Research
- Extracellular Modulators

Genotype: Tnf^tm1Gkl related

Apoptosis Research
- Extracellular Modulators
Cancer Research
- Growth Factors/Receptors/Cytokines
- Increased Tumor Incidence
  - Skin Cancers
  - Skin Cancers: Resistant
Cardiovascular Research
- Hypotriglyceridemia
Diabetes and Obesity Research
- Obesity Without Diabetes
  - induced
Endocrine Deficiency Research
- Spleen Defects
Hematological Research
- Immunological Defects
Immunology, Inflammation and Autoimmunity Research
- Growth Factors/Receptors/Cytokines
- Immunodeficiency
- Inflammation
- T Cell Receptor Signaling Defects
Internal/Organ Research
- Spleen Defects
Neurobiology Research
- Neurodegeneration

Mammalian Phenotype Terms by Genotype

Genotype: Tnf^tm1Gkl/Tnf^tm1Gkl
C.129S-Tnf^tm1Gkl

neoplasm

decreased incidence of tumors by chemical induction
- DMBA and TPA-treated mice exhibit papillomas than in similarly treated wild-type mice

homeostasis/metabolism phenotype

decreased incidence of tumors by chemical induction
- DMBA and TPA-treated mice exhibit papillomas than in similarly treated wild-type mice

The following phenotype information is associated with a similar, but not exact match to this JAX^® Mice strain

Genotype: Tnf^tm1Gkl/Tnf^tm1Gkl
involves: 129S/SvEv * C57BL/6J

immune system phenotype

abnormal Peyer's patch T cell area morphology
- T cells fail to segregate from B cells

abnormal Peyer's patch follicle morphology
- B cells fail to segregate from T cell areas

abnormal Peyer's patch germinal center morphology
- upon immunization with a T cell dependent antigen, germinal centers fail to develop

abnormal Peyer's patch morphology
- Peyer's patches have a flattened appearance

abnormal metallophilic macrophage morphology
- there are almost no metallophillic macrophages present in the marginal zone

abnormal spleen follicular dendritic cell network
- upon immunization with a T cell dependent antigen, there is a no formation of a follicular dendritic cell network

abnormal spleen marginal sinus morphology
- marginal sinus lining cells expressing mucosal addressin cell adhesion molecules are not present when immunized with a T cell antigen

abnormal spleen primary B follicle morphology
- B cells fail to form a defined primary follicle instead forming a ring-like structure that is partially mixed with the T cell region

absent spleen germinal center
- upon immunization with T cell dependent antigen, germinal centers fail to develop

decreased Peyer's patch number
- the mean number of Peyer's patches in mutant mice is 5 compared to 7 in wild-type mice

increased susceptibility to bacterial infection
- 7 days after a sublethal dose of Listeria monocytogenes, no mice survive compared to 60% survival of wild-type mice

hematopoietic system phenotype

abnormal metallophilic macrophage morphology
- there are almost no metallophillic macrophages present in the marginal zone

abnormal spleen follicular dendritic cell network
- upon immunization with a T cell dependent antigen, there is a no formation of a follicular dendritic cell network

abnormal spleen marginal sinus morphology
- marginal sinus lining cells expressing mucosal addressin cell adhesion molecules are not present when immunized with a T cell antigen

abnormal spleen primary B follicle morphology
- B cells fail to form a defined primary follicle instead forming a ring-like structure that is partially mixed with the T cell region

absent spleen germinal center
- upon immunization with T cell dependent antigen, germinal centers fail to develop

Genotype: Tnf^tm1Gkl/Tnf^tm1Gkl
involves: 129S/SvEv

immune system phenotype

abnormal chemokine secretion
- induction of MCP-1 was reduced in spleens of mutants infected with Listeria monocytogenes

decreased circulating tumor necrosis factor level
- serum TNF levels were reduced in mutants injected with LPS and could not be detected on day 2 of Listeria monocytogenes infection

decreased susceptibility to autoimmune disorder
- increased resistance to liver injury after ConA-induced autoimmune hepatitis, with only infiltrating cells but no liver necrosis detected

decreased susceptibility to endotoxin shock
- protected from S. aureus enterotoxin B induced toxic shock

increased susceptibility to bacterial infection
- loss of resistance against Listeria monocytogenes infection

homeostasis/metabolism phenotype

decreased circulating tumor necrosis factor level
- serum TNF levels were reduced in mutants injected with LPS and could not be detected on day 2 of Listeria monocytogenes infection

Genotype: Tnf^tm1Gkl/Tnf^tm1Gkl
B6;129S-Tnf^tm1Gkl/J

cellular phenotype

oligozoospermia
- at 12 weeks of age, male homozygotes show a ~53% reduction in epididymal sperm count relative to wild-type controls
- in mutant males, the number of sperm per testis weight is only ~68% that of wild-type controls

reproductive system phenotype

abnormal spermatogenesis
- at P26, the most advanced germ cells in mutant testes remain as late pachytene spermatocytes, instead of developing into haploid round spermatids as in wild-type testes
- at P33, only early elongated spermatids are noted in mutant testes, whereas late elongated spermatids are seen in wild-type testes
- male homozygotes show a significant delay in the onset of spermatogenesis, likely due to decreased testicular testosterone levels

abnormal spermiation
- at P37, no sperm are yet detected in mutant epididymides
- at P56, spermatozoa are detected at the luminal edge of seminiferous epithelia in both wild-type and mutant testes; however, the lumen is only dilated in wild-type tubules indicating active release of sperm

abnormal testes secretion
- after puberty, male homozygotes display significantly lower testicular testosterone levels than wild-type males, as a result of higher anti-Mullerian hormone levels in mutant testes

abnormal testis physiology
- after puberty (P30 to adulthood), mRNA levels of key steroidogenesis-related genes are significantly lower in mutant testes than in wild-type testes

decreased testis weight
- at 12 weeks of age, male homozygotes show a ~30% reduction in average testis weight relative to wild-type controls

oligozoospermia
- at 12 weeks of age, male homozygotes show a ~53% reduction in epididymal sperm count relative to wild-type controls
- in mutant males, the number of sperm per testis weight is only ~68% that of wild-type controls

endocrine/exocrine gland phenotype

abnormal testes secretion
- after puberty, male homozygotes display significantly lower testicular testosterone levels than wild-type males, as a result of higher anti-Mullerian hormone levels in mutant testes

abnormal testis physiology
- after puberty (P30 to adulthood), mRNA levels of key steroidogenesis-related genes are significantly lower in mutant testes than in wild-type testes

decreased testis weight
- at 12 weeks of age, male homozygotes show a ~30% reduction in average testis weight relative to wild-type controls

Genotype: Tnf^tm1Gkl/Tnf^tm1Gkl
either: B6.129-Tnf^tm1Gkl or (involves: 129/Sv * C57BL/6)

immune system phenotype

decreased Peyer's patch number
- Peyer's patches are fewer in number

decreased susceptibility to bacterial infection
- homozygotes are protected from LPS/D-Gal induced shock

increased leukocyte cell number
- a modest increase in peripheral white cell count is seen compared to wild-type mice

increased lymphocyte cell number
- lymphocyte numbers are increased compared to Tnf^tm1.2Sned homozygotes

increased neutrophil cell number
- neutrophil numbers are increased compared to Tnf^tm1.2Sned homozygotes

increased susceptibility to parasitic infection
- homozygotes show increased sensitivity to systemic and alimentary L. monocytogenes infection

small Peyer's patches

hematopoietic system phenotype

increased leukocyte cell number
- a modest increase in peripheral white cell count is seen compared to wild-type mice

increased lymphocyte cell number
- lymphocyte numbers are increased compared to Tnf^tm1.2Sned homozygotes

increased neutrophil cell number
- neutrophil numbers are increased compared to Tnf^tm1.2Sned homozygotes

Genotype: Tnf^tm1Gkl/Tnf^tm1Gkl
involves: 129S/SvEv * C57BL/6

growth/size/body region phenotype

decreased body weight
- at 28 weeks, mutant animals weigh less

cellular phenotype

decreased keratinocyte proliferation
- following DMBA and TPA treatment compared with similarly treated wild-type mice

adipose tissue phenotype

abnormal fat pad morphology

decreased percent body fat/body weight

homeostasis/metabolism phenotype

abnormal glucose homeostasis

abnormal lipid homeostasis

decreased circulating glucose level
- decreased fasting plasma glucose concentrations at 28 weeks of age

decreased circulating insulin level
- decreased plasma insulin concentrations at 28 weeks of age

decreased circulating leptin level
- decreased plasma leptin concentrations at 28 weeks of age

decreased circulating triglyceride level
- decreased plasma triglyceride concentrations at 28 weeks of age

decreased incidence of tumors by chemical induction
- DMBA and TPA-treated mice exhibit papillomas that develop with a greater latency than in similarly treated wild-type mice DMBA and TPA-treated mice exhibit papillomas that develop with a greater latency than in similarly treated wild-type mice however, malignant progression of tumors is normal lignant progression of tumors is normal
- however, malignant progression of tumors is normal

immune system phenotype

abnormal Peyer's patch follicle morphology
- B cells are present but no organized follicles are seen and organized follicular dendritic cell networks are absent

abnormal Peyer's patch morphology
- the typical subepithelial dome areas fail to form

abnormal inflammatory response
- when treated with D-gal (a hepatotoxin) at 20 mg/animal and doses of lipopolysaccharide (LPS) up to 100ug/25g body weight, mutants are completely resistant to LPS-induced death, but wild-type mice all die at 100-fold lower LPS doses

abnormal lymph node B cell domain morphology
- B cell follicles and follicular dendritic cell network formation are impaired in mesenteric and peripheral lymph nodes; however, B cells are present and B and T cell areas are segregated

abnormal lymphocyte physiology
- after intraperitoneal injection of SRBC, mutants exhibit severely impaired SRBC-specific IgG1 antibody responses

abnormal macrophage physiology
- LPS-stimulated thioglycollate-elicited peritoneal macrophages (TEPMs) cannot induce thymocyte proliferation, but stimulated TEPMs in wild-type and Tnf^tm3Gki homozygotes induce thymocyte proliferation with equal efficiency

abnormal mesenteric lymph node morphology
- mesenteric lymph nodes (MLN) lack organized B cell follicles but occasionally have GC-like regions that are centered in B cell areas

abnormal spleen follicular dendritic cell network
- organized follicular dendritic cell networks are absent

abnormal spleen primary B follicle morphology
- absence of splenic primary B cell follicles

absent follicular dendritic cells
- organized follicular dendritic cell networks are absent

absent spleen germinal center
- after immunization with sheep red blood cells (SRBCs), mutants fail to form organized germinal centers
- inability to form organized germinal centers

decreased Peyer's patch number
- average of 2 - 4 per mouse compared to 6 - 8 in wild-type mice

decreased inflammatory response
- in the skin following treatment with TPA compared with similarly treated wild-type mice

decreased susceptibility to experimental autoimmune encephalomyelitis
- 16 days post-immunization with pertussis toxin, mutants begin to show clinical signs of experimental allergic encephalomyelitis (EAE) which progresses to chronic non-remitting disease compared to wild-type mice which show signs of EAE at 12 days post-injectiona and peak EAE occurs at ~15 days, with gradual remission and results in only a mild deficitctiona and peak EAE occurs at ~15 days, with gradual remission and results in only a mild deficit

decreased susceptibility to type IV hypersensitivity reaction
- impaired contact hypersensitivity response

immune system phenotype
- mutant spleen cells isolated 49 days after myelin oligodendrocyte glycoprotein (MOG) display lack of autoimmune T cell responses (proliferation) to MOG peptide, similar to wild type spleen cells
- mutant spleen cells isolated 49 days after myelin oligodendrocyte glycoprotein (MOG) display lack of autoimmune T cell responses (proliferation) to MOG peptide, similar to wild-type spleen cells

increased susceptibility to bacterial infection
- susceptibility to death from Listeria monocytogenes infection
- with challenge at high doses (10000 cfu) of Listeria monocytogenes (LM), mutants show high sensitivity with maximal lethality at 6 days post-infection, compared to wild-type; mutants are highly sensitive when challenged with a physiological dose of LM (100 cfu) compared to wild-type0 cfu) compared to wild-type

hematopoietic system phenotype

abnormal lymphocyte physiology
- after intraperitoneal injection of SRBC, mutants exhibit severely impaired SRBC-specific IgG1 antibody responses

abnormal macrophage physiology
- LPS-stimulated thioglycollate-elicited peritoneal macrophages (TEPMs) cannot induce thymocyte proliferation, but stimulated TEPMs in wild-type and Tnf^tm3Gki homozygotes induce thymocyte proliferation with equal efficiency

abnormal spleen follicular dendritic cell network
- organized follicular dendritic cell networks are absent

abnormal spleen primary B follicle morphology
- absence of splenic primary B cell follicles

absent spleen germinal center
- after immunization with sheep red blood cells (SRBCs), mutants fail to form organized germinal centers
- inability to form organized germinal centers

neoplasm

decreased incidence of tumors by chemical induction
- DMBA and TPA-treated mice exhibit papillomas that develop with a greater latency than in similarly treated wild-type mice DMBA and TPA-treated mice exhibit papillomas that develop with a greater latency than in similarly treated wild-type mice however, malignant progression of tumors is normal lignant progression of tumors is normal
- however, malignant progression of tumors is normal

craniofacial phenotype

abnormal alveolar process morphology
- modest alveolar bone loss at 30 weeks

skeleton phenotype

abnormal alveolar process morphology
- modest alveolar bone loss at 30 weeks

abnormal trabecular bone morphology
- 32% increase in trabecular bone volume

increased bone mineral density
- significantly increased

increased osteoblast cell number

integument phenotype

decreased keratinocyte proliferation
- following DMBA and TPA treatment compared with similarly treated wild-type mice

References

Pasparakis M; Alexopoulou L; Episkopou V; Kollias G. 1996. Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response [see comments] J Exp Med 184(4):1397-411. PubMed: 8879212 MGI: J:47673

Additional - Tnf^tm1Gkl related

Abdullah Z; Geiger S; Nino-Castro A; Bottcher JP; Muraliv E; Gaidt M; Schildberg FA; Riethausen K; Flossdorf J; Krebs W; Chakraborty T; Kurts C; Schultze JL; Knolle PA; Klotz L. 2012. Lack of PPARgamma in myeloid cells confers resistance to Listeria monocytogenes infection. PLoS One 7(5):e37349. PubMed: 22629382 MGI: J:196535
Abe K; Yarovinsky FO; Murakami T; Shakhov AN; Tumanov AV; Ito D; Drutskaya LN; Pfeffer K; Kuprash DV; Komschlies KL; Nedospasov SA. 2003. Distinct contributions of TNF and LT cytokines to the development of dendritic cells in vitro and their recruitment in vivo. Blood 101(4):1477-83. PubMed: 12560241 MGI: J:115537
Abo-Ouf H; Hooper AW; White EJ; van Rensburg HJ; Trigatti BL; Igdoura SA. 2013. Deletion of tumor necrosis factor-alpha ameliorates neurodegeneration in Sandhoff disease mice. Hum Mol Genet 22(19):3960-75. PubMed: 23727835 MGI: J:201101
Acharyya S; Villalta SA; Bakkar N; Bupha-Intr T; Janssen PM; Carathers M; Li ZW; Beg AA; Ghosh S; Sahenk Z; Weinstein M; Gardner KL; Rafael-Fortney JA; Karin M; Tidball JG; Baldwin AS; Guttridge DC. 2007. Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy. J Clin Invest 117(4):889-901. PubMed: 17380205 MGI: J:121279
Akassoglou K; Bauer J; Kassiotis G; Pasparakis M; Lassmann H; Kollias G; Probert L. 1998. Oligodendrocyte apoptosis and primary demyelination induced by local TNF/p55TNF receptor signaling in the central nervous system of transgenic mice: models for multiple sclerosis with primary oligodendrogliopathy. Am J Pathol 153(3):801-13. PubMed: 9736029 MGI: J:106592
Akassoglou K; Douni E; Bauer J; Lassmann H; Kollias G; Probert L. 2003. Exclusive tumor necrosis factor (TNF) signaling by the p75TNF receptor triggers inflammatory ischemia in the CNS of transgenic mice. Proc Natl Acad Sci U S A 100(2):709-14. PubMed: 12522266 MGI: J:135049
Alayan J; Ivanovski S; Farah CS. 2007. Alveolar bone loss in T helper 1/T helper 2 cytokine-deficient mice. J Periodontal Res 42(2):97-103. PubMed: 17305866 MGI: J:147935
Alexopoulou L; Kranidioti K; Xanthoulea S; Denis M; Kotanidou A; Douni E; Blackshear PJ; Kontoyiannis DL; Kollias G. 2006. Transmembrane TNF protects mutant mice against intracellular bacterial infections, chronic inflammation and autoimmunity. Eur J Immunol 36(10):2768-80. PubMed: 16983719 MGI: J:114740
Alexopoulou L; Pasparakis M; Kollias G. 1997. A murine transmembrane tumor necrosis factor (TNF) transgene induces arthritis by cooperative p55/p75 TNF receptor signaling. Eur J Immunol 27(10):2588-92. PubMed: 9368614 MGI: J:43603
Anderson AL; Sporici R; Lambris J; Larosa D; Levinson AI. 2006. Pathogenesis of B-cell superantigen-induced immune complex-mediated inflammation. Infect Immun 74(2):1196-203. PubMed: 16428769 MGI: J:104987
Ando T; Matsumoto K; Namiranian S; Yamashita H; Glatthorn H; Kimura M; Dolan BR; Lee JJ; Galli SJ; Kawakami Y; Jamora C; Kawakami T. 2013. Mast Cells Are Required for Full Expression of Allergen/SEB-Induced Skin Inflammation. J Invest Dermatol 133(12):2695-705. PubMed: 23752044 MGI: J:202870
Andoh M; Zhang G; Russell-Lodrigue KE; Shive HR; Weeks BR; Samuel JE. 2007. T Cells Are Essential for Bacterial Clearance, and Gamma Interferon, Tumor Necrosis Factor Alpha, and B Cells Are Crucial for Disease Development in Coxiella burnetii Infection in Mice. Infect Immun 75(7):3245-55. PubMed: 17438029 MGI: J:122426
Andrade RM; Wessendarp M; Portillo JA; Yang JQ; Gomez FJ; Durbin JE; Bishop GA; Subauste CS. 2005. TNF receptor-associated factor 6-dependent CD40 signaling primes macrophages to acquire antimicrobial activity in response to TNF-alpha. J Immunol 175(9):6014-21. PubMed: 16237096 MGI: J:119350
Aoki R; Kawamura T; Goshima F; Ogawa Y; Nakae S; Nakao A; Moriishi K; Nishiyama Y; Shimada S. 2013. Mast Cells Play a Key Role in Host Defense against Herpes Simplex Virus Infection through TNF-alpha and IL-6 Production. J Invest Dermatol 133(9):2170-9. PubMed: 23528820 MGI: J:200049
Arnett HA; Mason J; Marino M; Suzuki K; Matsushima GK; Ting JP. 2001. TNFalpha promotes proliferation of oligodendrocyte progenitors and remyelination. Nat Neurosci 4(11):1116-22. PubMed: 11600888 MGI: J:72695
Arsenijevic D; Clavel S; Sanchis D; Plamondon J; Huang Q; Ricquier D; Rouger L; Richard D. 2007. Induction of Ucp2 expression in brain phagocytes and neurons following murine toxoplasmosis: an essential role of IFN-gamma and an association with negative energy balance. J Neuroimmunol 186(1-2):121-32. PubMed: 17467814 MGI: J:124552
Ashkar AA; Di Santo JP; Croy BA. 2000. Interferon gamma contributes to initiation of uterine vascular modification, decidual integrity, and uterine natural killer cell maturation during normal murine pregnancy [see comments] J Exp Med 192(2):259-70. PubMed: 10899912 MGI: J:63645
Awad AE; Kandalam V; Chakrabarti S; Wang X; Penninger JM; Davidge ST; Oudit GY; Kassiri Z. 2010. Tumor necrosis factor induces matrix metalloproteinases in cardiomyocytes and cardiofibroblasts differentially via superoxide production in a PI3K{gamma}-dependent manner. Am J Physiol Cell Physiol 298(3):C679-92. PubMed: 20007453 MGI: J:157465
Baluk P; Yao LC; Feng J; Romano T; Jung SS; Schreiter JL; Yan L; Shealy DJ; McDonald DM. 2009. TNF-alpha drives remodeling of blood vessels and lymphatics in sustained airway inflammation in mice. J Clin Invest 119(10):2954-64. PubMed: 19759514 MGI: J:154641
Barber EM; Fazzari M; Pollard JW. 2005. Th1 cytokines are essential for placental immunity to Listeria monocytogenes. Infect Immun 73(10):6322-31. PubMed: 16177303 MGI: J:104232
Barker V; Middleton G; Davey F; Davies AM. 2001. TNFalpha contributes to the death of NGF-dependent neurons during development. Nat Neurosci 4(12):1194-8. PubMed: 11685224 MGI: J:109370
Barrios B; Baez NS; Reynolds D; Iribarren P; Cejas H; Young HA; Rodriguez-Galan MC. 2014. Abrogation of TNFalpha production during cancer immunotherapy is crucial for suppressing side effects due to the systemic expression of IL-12. PLoS One 9(2):e90116. PubMed: 24587231 MGI: J:214472
Battula S; Hao S; Pedraza PL; Stier CT; Ferreri NR. 2011. Tumor necrosis factor-{alpha} is an endogenous inhibitor of Na+-K+-2Cl- cotransporter (NKCC2) isoform A in the thick ascending limb. Am J Physiol Renal Physiol 301(1):F94-F100. PubMed: 21511694 MGI: J:174108
Baxevanis CN; Voutsas IF; Tsitsilonis OE; Tsiatas ML; Gritzapis AD; Papamichail M. 2000. Compromised anti-tumor responses in tumor necrosis factor-alpha knockout mice. Eur J Immunol 30(7):1957-66. PubMed: 10940885 MGI: J:63509
Bertrand F; Rochotte J; Colacios C; Montfort A; Tilkin-Mariame AF; Touriol C; Rochaix P; Lajoie-Mazenc I; Andrieu-Abadie N; Levade T; Benoist H; Segui B. 2015. Blocking Tumor Necrosis Factor alpha Enhances CD8 T-cell-Dependent Immunity in Experimental Melanoma. Cancer Res 75(13):2619-28. PubMed: 25977337 MGI: J:222932
Biedermann T; Kneilling M; Mailhammer R; Maier K; Sander CA; Kollias G; Kunkel SL; Hultner L; Rocken M. 2000. Mast cells control neutrophil recruitment during T cell-mediated delayed-type hypersensitivity reactions through tumor necrosis factor and macrophage inflammatory protein 2 J Exp Med 192(10):1441-52. PubMed: 11085746 MGI: J:65843
Binstadt BA; Patel PR; Alencar H; Nigrovic PA; Lee DM; Mahmood U; Weissleder R; Mathis D; Benoist C. 2006. Particularities of the vasculature can promote the organ specificity of autoimmune attack. Nat Immunol 7(3):284-92. PubMed: 16444258 MGI: J:112604
Bitsaktsis C; Huntington J; Winslow G. 2004. Production of IFN-gamma by CD4 T cells is essential for resolving ehrlichia infection. J Immunol 172(11):6894-901. PubMed: 15153508 MGI: J:90518
Bitsaktsis C; Nandi B; Racine R; MacNamara KC; Winslow G. 2007. T-Cell-independent humoral immunity is sufficient for protection against fatal intracellular ehrlichia infection. Infect Immun 75(10):4933-41. PubMed: 17664264 MGI: J:125283
Boesten LS; Zadelaar AS; van Nieuwkoop A; Gijbels MJ; de Winther MP; Havekes LM; van Vlijmen BJ. 2005. Tumor necrosis factor-alpha promotes atherosclerotic lesion progression in APOE*3-Leiden transgenic mice. Cardiovasc Res 66(1):179-85. PubMed: 15769461 MGI: J:109170
Bollmann F; Wu Z; Oelze M; Siuda D; Xia N; Henke J; Daiber A; Li H; Stumpo DJ; Blackshear PJ; Kleinert H; Pautz A. 2014. Endothelial dysfunction in tristetraprolin-deficient mice is not caused by enhanced tumor necrosis factor-alpha expression. J Biol Chem 289(22):15653-65. PubMed: 24727475 MGI: J:214114
Bonnet MC; Preukschat D; Welz PS; van Loo G; Ermolaeva MA; Bloch W; Haase I; Pasparakis M. 2011. The Adaptor Protein FADD Protects Epidermal Keratinocytes from Necroptosis In Vivo and Prevents Skin Inflammation. Immunity 35(4):572-82. PubMed: 22000287 MGI: J:177639
Boone DL; Turer EE; Lee EG; Ahmad RC; Wheeler MT; Tsui C; Hurley P; Chien M; Chai S; Hitotsumatsu O; McNally E; Pickart C; Ma A. 2004. The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses. Nat Immunol 5(10):1052-60. PubMed: 15334086 MGI: J:92694
Bouchard C; Page J; Bedard A; Tremblay P; Vallieres L. 2007. G protein-coupled receptor 84, a microglia-associated protein expressed in neuroinflammatory conditions. Glia 55(8):790-800. PubMed: 17390309 MGI: J:156094
Bouchlaka MN; Sckisel GD; Chen M; Mirsoian A; Zamora AE; Maverakis E; Wilkins DE; Alderson KL; Hsiao HH; Weiss JM; Monjazeb AM; Hesdorffer C; Ferrucci L; Longo DL; Blazar BR; Wiltrout RH; Redelman D; Taub DD; Murphy WJ. 2013. Aging predisposes to acute inflammatory induced pathology after tumor immunotherapy. J Exp Med 210(11):2223-37. PubMed: 24081947 MGI: J:204052
Brandl K; Plitas G; Schnabl B; DeMatteo RP; Pamer EG. 2007. MyD88-mediated signals induce the bactericidal lectin RegIII gamma and protect mice against intestinal Listeria monocytogenes infection. J Exp Med 204(8):1891-900. PubMed: 17635956 MGI: J:125955
Branen L; Hovgaard L; Nitulescu M; Bengtsson E; Nilsson J; Jovinge S. 2004. Inhibition of tumor necrosis factor-alpha reduces atherosclerosis in apolipoprotein E knockout mice. Arterioscler Thromb Vasc Biol 24(11):2137-42. PubMed: 15345516 MGI: J:103699
Brehm MA; Daniels KA; Welsh RM. 2005. Rapid production of TNF-alpha following TCR engagement of naive CD8 T cells. J Immunol 175(8):5043-9. PubMed: 16210607 MGI: J:119124
Buhtoiarov IN; Lum HD; Berke G; Sondel PM; Rakhmilevich AL. 2006. Synergistic activation of macrophages via CD40 and TLR9 results in T cell independent antitumor effects. J Immunol 176(1):309-18. PubMed: 16365423 MGI: J:126263
Byrne KT; Vonderheide RH. 2016. CD40 Stimulation Obviates Innate Sensors and Drives T Cell Immunity in Cancer. Cell Rep 15(12):2719-32. PubMed: 27292635 MGI: J:238302
Cachaco AS; Carvalho T; Santos AC; Igreja C; Fragoso R; Osorio C; Ferreira M; Serpa J; Correia S; Pinto-do-O P; Dias S. 2010. TNF-alpha regulates the effects of irradiation in the mouse bone marrow microenvironment. PLoS One 5(2):e8980. PubMed: 20126546 MGI: J:157937
Calzascia T; Pellegrini M; Hall H; Sabbagh L; Ono N; Elford AR; Mak TW; Ohashi PS. 2007. TNF-alpha is critical for antitumor but not antiviral T cell immunity in mice. J Clin Invest 117(12):3833-45. PubMed: 17992258 MGI: J:130779
Campana WM; Li X; Dragojlovic N; Janes J; Gaultier A; Gonias SL. 2006. The low-density lipoprotein receptor-related protein is a pro-survival receptor in Schwann cells: possible implications in peripheral nerve injury. J Neurosci 26(43):11197-207. PubMed: 17065459 MGI: J:114965
Campbell K. 2010. Mice homozygous for a dystroglycan 1 mutation with exon flanked by loxP sites are viable and fertile and appear healthy MGI Direct Data Submission :. MGI: J:156588
Carmen J; Rothstein JD; Kerr DA. 2009. Tumor necrosis factor-alpha modulates glutamate transport in the CNS and is a critical determinant of outcome from viral encephalomyelitis. Brain Res 1263:143-54. PubMed: 19368827 MGI: J:148095
Carpentier PA; Dingman AL; Palmer TD. 2011. Placental TNF-alpha Signaling in Illness-Induced Complications of Pregnancy. Am J Pathol 178(6):2802-10. PubMed: 21641402 MGI: J:173471
Chatterjee S; Eby JM; Al-Khami AA; Soloshchenko M; Kang HK; Kaur N; Naga OS; Murali A; Nishimura MI; Le Poole IC; Mehrotra S. 2014. A quantitative increase in regulatory T cells controls development of vitiligo. J Invest Dermatol 134(5):1285-94. PubMed: 24366614 MGI: J:208054
Chatzidakis I; Fousteri G; Tsoukatou D; Kollias G; Mamalaki C. 2007. An essential role for TNF in modulating thresholds for survival, activation, and tolerance of CD8+ T cells. J Immunol 178(11):6735-45. PubMed: 17513720 MGI: J:147850
Chen CY; Liu HY; Hsueh YP. 2017. TLR3 downregulates expression of schizophrenia gene Disc1 via MYD88 to control neuronal morphology. EMBO Rep 18(1):169-183. PubMed: 27979975 MGI: J:239308
Chen HC; Hofman FM; Kung JT; Lin YD; Wu-Hsieh BA. 2007. Both virus and tumor necrosis factor alpha are critical for endothelium damage in a mouse model of dengue virus-induced hemorrhage. J Virol 81(11):5518-26. PubMed: 17360740 MGI: J:153322
Chen LY; Yang-Yen HF; Tsai CC; Thio CL; Chuang HL; Yang LT; Shen LF; Song IW; Liu KM; Huang YT; Liu FT; Chang YJ; Chen YT; Yen JJ. 2017. Protein Palmitoylation by ZDHHC13 Protects Skin against Microbial-Driven Dermatitis. J Invest Dermatol 137(4):894-904. PubMed: 28017833 MGI: J:240181
Chien H; Dix RD. 2012. Evidence for multiple cell death pathways during development of experimental cytomegalovirus retinitis in mice with retrovirus-induced immunosuppression: apoptosis, necroptosis, and pyroptosis. J Virol 86(20):10961-78. PubMed: 22837196 MGI: J:196525
Chopra M; Biehl M; Steinfatt T; Brandl A; Kums J; Amich J; Vaeth M; Kuen J; Holtappels R; Podlech J; Mottok A; Kraus S; Jordan-Garrote AL; Bauerlein CA; Brede C; Ribechini E; Fick A; Seher A; Polz J; Ottmuller KJ; Baker J; Nishikii H; Ritz M; Mattenheimer K; Schwinn S; Winter T; Schafer V; Krappmann S; Einsele H; Muller TD; Reddehase MJ; Lutz MB; Mannel DN; Berberich-Siebelt F; Wajant H; Beilhack A. 2016. Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion. J Exp Med 213(9):1881-900. PubMed: 27526711 MGI: J:236727
Chopra M; Lang I; Salzmann S; Pachel C; Kraus S; Bauerlein CA; Brede C; Garrote AL; Mattenheimer K; Ritz M; Schwinn S; Graf C; Schafer V; Frantz S; Einsele H; Wajant H; Beilhack A. 2013. Tumor necrosis factor induces tumor promoting and anti-tumoral effects on pancreatic cancer via TNFR1. PLoS One 8(9):e75737. PubMed: 24098720 MGI: J:207733
Chopra M; Riedel SS; Biehl M; Krieger S; von Krosigk V; Bauerlein CA; Brede C; Jordan Garrote AL; Kraus S; Schafer V; Ritz M; Mattenheimer K; Degla A; Mottok A; Einsele H; Wajant H; Beilhack A. 2013. Tumor necrosis factor receptor 2-dependent homeostasis of regulatory T cells as a player in TNF-induced experimental metastasis. Carcinogenesis 34(6):1296-303. PubMed: 23385062 MGI: J:198326
Cohen JN; Tewalt EF; Rouhani SJ; Buonomo EL; Bruce AN; Xu X; Bekiranov S; Fu YX; Engelhard VH. 2014. Tolerogenic properties of lymphatic endothelial cells are controlled by the lymph node microenvironment. PLoS One 9(2):e87740. PubMed: 24503860 MGI: J:212969
Collazo CM; Meierovics AI; De Pascalis R; Wu TH; Lyons CR; Elkins KL. 2009. T cells from lungs and livers of Francisella tularensis-immune mice control the growth of intracellular bacteria. Infect Immun 77(5):2010-21. PubMed: 19237526 MGI: J:148524
Coursey TG; Chen PW; Niederkorn JY. 2011. Abrogating TNF-{alpha} Expression Prevents Bystander Destruction of Normal Tissues during iNOS-Mediated Elimination of Intraocular Tumors. Cancer Res 71(7):2445-54. PubMed: 21307132 MGI: J:170908
Croker BA; Lawson BR; Berger M; Eidenschenk C; Blasius AL; Moresco EM; Sovath S; Cengia L; Shultz LD; Theofilopoulos AN; Pettersson S; Beutler BA. 2008. Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger. Proc Natl Acad Sci U S A 105(39):15028-33. PubMed: 18806225 MGI: J:142845
Crow AR; Song S; Semple JW; Freedman J; Lazarus AH. 2007. A role for IL-1 receptor antagonist or other cytokines in the acute therapeutic effects of IVIg? Blood 109(1):155-8. PubMed: 16954498 MGI: J:142178
Csiszar A; Smith KE; Koller A; Kaley G; Edwards JG; Ungvari Z. 2005. Regulation of bone morphogenetic protein-2 expression in endothelial cells: role of nuclear factor-kappaB activation by tumor necrosis factor-alpha, H2O2, and high intravascular pressure. Circulation 111(18):2364-72. PubMed: 15851600 MGI: J:111595
Cusson N; Oikemus S; Kilpatrick ED; Cunningham L; Kelliher M. 2002. The death domain kinase RIP protects thymocytes from tumor necrosis factor receptor type 2-induced cell death. J Exp Med 196(1):15-26. PubMed: 12093867 MGI: J:120699
Dajani R; Sanlioglu S; Zhang Y; Li Q; Monick MM; Lazartigues E; Eggleston T; Davisson RL; Hunninghake GW; Engelhardt JF. 2007. Pleiotropic functions of TNF-alpha determine distinct IKKbeta-dependent hepatocellular fates in response to LPS. Am J Physiol Gastrointest Liver Physiol 292(1):G242-52. PubMed: 16935850 MGI: J:120596
Damjanovic D; Divangahi M; Kugathasan K; Small CL; Zganiacz A; Brown EG; Hogaboam CM; Gauldie J; Xing Z. 2011. Negative regulation of lung inflammation and immunopathology by TNF-alpha during acute influenza infection. Am J Pathol 179(6):2963-76. PubMed: 22001698 MGI: J:180064
Dawicki W; Jawdat DW; Xu N; Marshall JS. 2010. Mast cells, histamine, and IL-6 regulate the selective influx of dendritic cell subsets into an inflamed lymph node. J Immunol 184(4):2116-23. PubMed: 20083654 MGI: J:159485
Dawn B; Guo Y; Rezazadeh A; Wang OL; Stein AB; Hunt G; Varma J; Xuan YT; Wu WJ; Tan W; Zhu X; Bolli R. 2004. Tumor necrosis factor-alpha does not modulate ischemia/reperfusion injury in naive myocardium but is essential for the development of late preconditioning. J Mol Cell Cardiol 37(1):51-61. PubMed: 15242735 MGI: J:132469
DeBerge MP; Ely KH; Cheng GS; Enelow RI. 2013. ADAM17-mediated processing of TNF-alpha expressed by antiviral effector CD8+ T cells is required for severe T-cell-mediated lung injury. PLoS One 8(11):e79340. PubMed: 24223177 MGI: J:209328
Defamie V; Sanchez O; Murthy A; Khokha R. 2015. TIMP3 controls cell fate to confer hepatocellular carcinoma resistance. Oncogene 34(31):4098-108. PubMed: 25347747 MGI: J:224257
Dhadialla PS; Ohiorhenuan IE; Cohen A; Strickland S. 2009. Maximum-entropy network analysis reveals a role for tumor necrosis factor in peripheral nerve development and function. Proc Natl Acad Sci U S A :. PubMed: 19597151 MGI: J:150782
Ding J; Song D; Ye X; Liu SF. 2009. A pivotal role of endothelial-specific NF-kappaB signaling in the pathogenesis of septic shock and septic vascular dysfunction. J Immunol 183(6):4031-8. PubMed: 19692637 MGI: J:152325
Dissanayake D; Hall H; Berg-Brown N; Elford AR; Hamilton SR; Murakami K; Deluca LS; Gommerman JL; Ohashi PS. 2011. Nuclear factor-kappaB1 controls the functional maturation of dendritic cells and prevents the activation of autoreactive T cells. Nat Med 17(12):1663-7. PubMed: 22081022 MGI: J:180207
Doener F; Michel A; Reuter S; Friedrich P; Bohm L; Relle M; Codarri L; Tenzer S; Klein M; Bopp T; Schmitt E; Schild H; Radsak MP; Taube C; Stassen M; Becker M. 2013. Mast cell-derived mediators promote murine neutrophil effector functions. Int Immunol 25(10):553-61. PubMed: 23728776 MGI: J:201921
Dokun AO; Chu DT; Yang L; Bendelac AS; Yokoyama WM. 2001. Analysis of in situ NK cell responses during viral infection. J Immunol 167(9):5286-93. PubMed: 11673544 MGI: J:72673
Domercq M; Brambilla L; Pilati E; Marchaland J; Volterra A; Bezzi P. 2006. P2Y1 receptor-evoked glutamate exocytosis from astrocytes: control by tumor necrosis factor-alpha and prostaglandins. J Biol Chem 281(41):30684-96. PubMed: 16882655 MGI: J:117295
Douni E; Kollias G. 1998. A critical role of the p75 tumor necrosis factor receptor (p75TNF-R) in organ inflammation independent of TNF, lymphotoxin alpha, or the p55TNF-R. J Exp Med 188(7):1343-52. PubMed: 9763613 MGI: J:114744
Dumitru CD; Ceci JD; Tsatsanis C; Kontoyiannis D; Stamatakis K; Lin JH; Patriotis C; Jenkins NA; Copeland NG; Kollias G; Tsichlis PN. 2000. TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway. Cell 103(7):1071-83. PubMed: 11163183 MGI: J:66503
Edwards CK 3rd; Bendele AM; Reznikov LI; Fantuzzi G; Chlipala ES; Li L; Moldawer LL; Mountz JD; Li YY; Dinarello CA. 2006. Soluble human p55 and p75 tumor necrosis factor receptors reverse spontaneous arthritis in transgenic mice expressing transmembrane tumor necrosis factor alpha. Arthritis Rheum 54(9):2872-85. PubMed: 16947419 MGI: J:134143
Egea L; McAllister CS; Lakhdari O; Minev I; Shenouda S; Kagnoff MF. 2013. GM-CSF Produced by Nonhematopoietic Cells Is Required for Early Epithelial Cell Proliferation and Repair of Injured Colonic Mucosa. J Immunol 190(4):1702-13. PubMed: 23325885 MGI: J:193407
Ehlken H; Krishna-Subramanian S; Ochoa-Callejero L; Kondylis V; Nadi NE; Straub BK; Schirmacher P; Walczak H; Kollias G; Pasparakis M. 2014. Death receptor-independent FADD signalling triggers hepatitis and hepatocellular carcinoma in mice with liver parenchymal cell-specific NEMO knockout. Cell Death Differ 21(11):1721-32. PubMed: 24971483 MGI: J:230157
Ehrhardt H; Pritzke T; Oak P; Kossert M; Biebach L; Forster K; Koschlig M; Alvira CM; Hilgendorff A. 2016. Absence of TNF-alpha enhances inflammatory response in the newborn lung undergoing mechanical ventilation. Am J Physiol Lung Cell Mol Physiol 310(10):L909-18. PubMed: 27016588 MGI: J:234859
Endres R; Alimzhanov MB; Plitz T; Futterer A; Kosco-Vilbois MH; Nedospasov SA; Rajewsky K; Pfeffer K. 1999. Mature follicular dendritic cell networks depend on expression of lymphotoxin beta receptor by radioresistant stromal cells and of lymphotoxin beta and tumor necrosis factor by B cells. J Exp Med 189(1):159-68. PubMed: 9874572 MGI: J:119173
Ewing P; Miklos S; Olkiewicz KM; Muller G; Andreesen R; Holler E; Cooke KR; Hildebrandt GC. 2007. Donor CD4+ T-cell production of tumor necrosis factor alpha significantly contributes to the early proinflammatory events of graft-versus-host disease. Exp Hematol 35(1):155-63. PubMed: 17198884 MGI: J:123193
Fabis MJ; Scott GS; Kean RB; Koprowski H; Hooper DC. 2007. Loss of blood-brain barrier integrity in the spinal cord is common to experimental allergic encephalomyelitis in knockout mouse models. Proc Natl Acad Sci U S A 104(13):5656-61. PubMed: 17372191 MGI: J:120115
Fei M; Bhatia S; Oriss TB; Yarlagadda M; Khare A; Akira S; Saijo S; Iwakura Y; Fallert Junecko BA; Reinhart TA; Foreman O; Ray P; Kolls J; Ray A. 2011. TNF-{alpha} from inflammatory dendritic cells (DCs) regulates lung IL-17A/IL-5 levels and neutrophilia versus eosinophilia during persistent fungal infection. Proc Natl Acad Sci U S A 108(13):5360-5. PubMed: 21402950 MGI: J:171233
Feng HM; Walker DH. 2004. Mechanisms of immunity to Ehrlichia muris: a model of monocytotropic ehrlichiosis. Infect Immun 72(2):966-71. PubMed: 14742542 MGI: J:87862
Fenger C; Drojdahl N; Wirenfeldt M; Sylvest L; Jorgensen OS; Meldgaard M; Lambertsen KL; Finsen B. 2006. Tumor necrosis factor and its p55 and p75 receptors are not required for axonal lesion-induced microgliosis in mouse fascia dentata. Glia 54(6):591-605. PubMed: 16927297 MGI: J:156117
Flaherty MP; Guo Y; Tiwari S; Rezazadeh A; Hunt G; Sanganalmath SK; Tang XL; Bolli R; Dawn B. 2008. The role of TNF-alpha receptors p55 and p75 in acute myocardial ischemia/reperfusion injury and late preconditioning. J Mol Cell Cardiol 45(6):735-41. PubMed: 18824172 MGI: J:143321
Fleischman AG; Aichberger KJ; Luty SB; Bumm TG; Petersen CL; Doratotaj S; Vasudevan KB; Latocha DH; Yang F; Press RD; Loriaux MM; Pahl HL; Silver RT; Agarwal A; O'Hare T; Druker BJ; Bagby GC; Deininger MW. 2011. TNFalpha facilitates clonal expansion of JAK2V617F positive cells in myeloproliferative neoplasms. Blood 118(24):6392-8. PubMed: 21860020 MGI: J:179034
Florido M; Appelberg R. 2004. Granuloma necrosis during Mycobacterium avium infection does not require tumor necrosis factor. Infect Immun 72(10):6139-41. PubMed: 15385519 MGI: J:93381
Florido M; Appelberg R. 2007. Characterization of the deregulated immune activation occurring at late stages of mycobacterial infection in TNF-deficient mice. J Immunol 179(11):7702-8. PubMed: 18025216 MGI: J:154805
Folgosa L; Zellner HB; El Shikh ME; Conrad DH. 2013. Disturbed follicular architecture in B cell A disintegrin and metalloproteinase (ADAM)10 knockouts is mediated by compensatory increases in ADAM17 and TNF-alpha shedding. J Immunol 191(12):5951-8. PubMed: 24227779 MGI: J:207127
Fontaine V; Mohand-Said S; Hanoteau N; Fuchs C; Pfizenmaier K; Eisel U. 2002. Neurodegenerative and neuroprotective effects of tumor Necrosis factor (TNF) in retinal ischemia: opposite roles of TNF receptor 1 and TNF receptor 2. J Neurosci 22(7):RC216. PubMed: 11917000 MGI: J:75537
Fujita S; Saika S; Kao WW; Fujita K; Miyamoto T; Ikeda K; Nakajima Y; Ohnishi Y. 2007. Endogenous TNF{alpha} Suppression of Neovascularization in Corneal Stroma in Mice. Invest Ophthalmol Vis Sci 48(7):3051-5. PubMed: 17591872 MGI: J:123273
Gao X; Belmadani S; Picchi A; Xu X; Potter BJ; Tewari-Singh N; Capobianco S; Chilian WM; Zhang C. 2007. Tumor necrosis factor-alpha induces endothelial dysfunction in Lepr(db) mice. Circulation 115(2):245-54. PubMed: 17200442 MGI: J:129770
Gao X; Xu X; Belmadani S; Park Y; Tang Z; Feldman AM; Chilian WM; Zhang C. 2007. TNF-alpha contributes to endothelial dysfunction by upregulating arginase in ischemia/reperfusion injury. Arterioscler Thromb Vasc Biol 27(6):1269-75. PubMed: 17413034 MGI: J:134912
Gao X; Zhang H; Schmidt AM; Zhang C. 2008. AGE/RAGE produces endothelial dysfunction in coronary arterioles in Type 2 diabetic mice. Am J Physiol Heart Circ Physiol 295(2):H491-8. PubMed: 18539754 MGI: J:138204
Gerber J; Bottcher T; Hahn M; Siemer A; Bunkowski S; Nau R. 2004. Increased mortality and spatial memory deficits in TNF-alpha-deficient mice in ceftriaxone-treated experimental pneumococcal meningitis. Neurobiol Dis 16(1):133-8. PubMed: 15207270 MGI: J:120390
Gilbert MR; Wagner NJ; Jones SZ; Wisz AB; Roques JR; Krum KN; Lee SR; Nickeleit V; Hulbert C; Thomas JW; Gauld SB; Vilen BJ. 2012. Autoreactive preplasma cells break tolerance in the absence of regulation by dendritic cells and macrophages. J Immunol 189(2):711-20. PubMed: 22675201 MGI: J:189561
Gill N; Deacon PM; Lichty B; Mossman KL; Ashkar AA. 2006. Induction of innate immunity against herpes simplex virus type 2 infection via local delivery of Toll-like receptor ligands correlates with beta interferon production. J Virol 80(20):9943-50. PubMed: 17005672 MGI: J:153329
Golan H; Levav T; Mendelsohn A; Huleihel M. 2004. Involvement of tumor necrosis factor alpha in hippocampal development and function. Cereb Cortex 14(1):97-105. PubMed: 14654461 MGI: J:106248
Gowing G; Dequen F; Soucy G; Julien JP. 2006. Absence of tumor necrosis factor-alpha does not affect motor neuron disease caused by superoxide dismutase 1 mutations. J Neurosci 26(44):11397-402. PubMed: 17079668 MGI: J:114680
Grenz A; Kim JH; Bauerle JD; Tak E; Eltzschig HK; Clambey ET. 2012. Adora2b adenosine receptor signaling protects during acute kidney injury via inhibition of neutrophil-dependent TNF-alpha release. J Immunol 189(9):4566-73. PubMed: 23028059 MGI: J:190594
Grivennikov SI; Tumanov AV; Liepinsh DJ; Kruglov AA; Marakusha BI; Shakhov AN; Murakami T; Drutskaya LN; Forster I; Clausen BE; Tessarollo L; Ryffel B; Kuprash DV; Nedospasov SA. 2005. Distinct and nonredundant in vivo functions of TNF produced by t cells and macrophages/neutrophils: protective and deleterious effects. Immunity 22(1):93-104. PubMed: 15664162 MGI: J:95684
Guma M; Stepniak D; Shaked H; Spehlmann ME; Shenouda S; Cheroutre H; Vicente-Suarez I; Eckmann L; Kagnoff MF; Karin M. 2011. Constitutive intestinal NF-kappaB does not trigger destructive inflammation unless accompanied by MAPK activation. J Exp Med 208(9):1889-900. PubMed: 21825016 MGI: J:177595
Gustavsson C; Agardh CD; Zetterqvist AV; Nilsson J; Agardh E; Gomez MF. 2010. Vascular cellular adhesion molecule-1 (VCAM-1) expression in mice retinal vessels is affected by both hyperglycemia and hyperlipidemia. PLoS One 5(9):e12699. PubMed: 20856927 MGI: J:165118
Hale LP; Greer PK. 2012. A novel murine model of inflammatory bowel disease and inflammation-associated colon cancer with ulcerative colitis-like features. PLoS One 7(7):e41797. PubMed: 22848611 MGI: J:189696
Hall KC; Hill D; Otero M; Plumb DA; Froemel D; Dragomir CL; Maretzky T; Boskey A; Crawford HC; Selleri L; Goldring MB; Blobel CP. 2013. ADAM17 controls endochondral ossification by regulating terminal differentiation of chondrocytes. Mol Cell Biol 33(16):3077-90. PubMed: 23732913 MGI: J:204569
Harmsen A; Kusser K; Hartson L; Tighe M; Sunshine MJ; Sedgwick JD; Choi Y; Littman DR; Randall TD. 2002. Cutting edge: organogenesis of nasal-associated lymphoid tissue (NALT) occurs independently of lymphotoxin-alpha (LT alpha) and retinoic acid receptor-related orphan receptor-gamma, but the organization of NALT is LT alpha dependent. J Immunol 168(3):986-90. PubMed: 11801629 MGI: J:111963
Hase H; Ando T; Eldeiry L; Brebene A; Peng Y; Liu L; Amano H; Davies TF; Sun L; Zaidi M; Abe E. 2006. TNFalpha mediates the skeletal effects of thyroid-stimulating hormone. Proc Natl Acad Sci U S A 103(34):12849-54. PubMed: 16908863 MGI: J:112918
Hayashi T; Cottam HB; Chan M; Jin G; Tawatao RI; Crain B; Ronacher L; Messer K; Carson DA; Corr M. 2008. Mast cell-dependent anorexia and hypothermia induced by mucosal activation of Toll-like receptor 7. Am J Physiol Regul Integr Comp Physiol 295(1):R123-32. PubMed: 18480244 MGI: J:148644
Helmby H. 2009. Gastrointestinal nematode infection exacerbates malaria-induced liver pathology. J Immunol 182(9):5663-71. PubMed: 19380813 MGI: J:147710
Henao-Mejia J; Elinav E; Jin C; Hao L; Mehal WZ; Strowig T; Thaiss CA; Kau AL; Eisenbarth SC; Jurczak MJ; Camporez JP; Shulman GI; Gordon JI; Hoffman HM; Flavell RA. 2012. Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature 482(7384):179-85. PubMed: 22297845 MGI: J:181354
Herz J; Johnson KR; McGavern DB. 2015. Therapeutic antiviral T cells noncytopathically clear persistently infected microglia after conversion into antigen-presenting cells. J Exp Med 212(8):1153-69. PubMed: 26122661 MGI: J:226451
Higuchi A; Ohashi K; Kihara S; Walsh K; Ouchi N. 2009. Adiponectin suppresses pathological microvessel formation in retina through modulation of tumor necrosis factor-alpha expression. Circ Res 104(9):1058-65. PubMed: 19342600 MGI: J:164773
Higuchi A; Ohashi K; Shibata R; Sono-Romanelli S; Walsh K; Ouchi N. 2010. Thiazolidinediones reduce pathological neovascularization in ischemic retina via an adiponectin-dependent mechanism. Arterioscler Thromb Vasc Biol 30(1):46-53. PubMed: 19910632 MGI: J:171798
Hirata N; Yanagawa Y; Ogura H; Satoh M; Noguchi M; Matsumoto M; Togashi H; Onoe K; Iwabuchi K. 2011. The role of tumor necrosis factor-alpha for interleukin-10 production by murine dendritic cells. Cell Immunol 266(2):165-71. PubMed: 20979991 MGI: J:167015
Hitotsumatsu O; Ahmad RC; Tavares R; Wang M; Philpott D; Turer EE; Lee BL; Shiffin N; Advincula R; Malynn BA; Werts C; Ma A. 2008. The ubiquitin-editing enzyme A20 restricts nucleotide-binding oligomerization domain containing 2-triggered signals. Immunity 28(3):381-90. PubMed: 18342009 MGI: J:132994
Hojilla CV; Jackson HW; Khokha R. 2011. TIMP3 Regulates Mammary Epithelial Apoptosis with Immune Cell Recruitment Through Differential TNF Dependence. PLoS One 6(10):e26718. PubMed: 22053204 MGI: J:178068
Homberg N; Adam C; Riedel T; Brenner C; Flatley A; Rocken M; Mocikat R. 2014. CD40-independent natural killer-cell help promotes dendritic cell vaccine-induced T-cell immunity against endogenous B-cell lymphoma. Int J Cancer 135(12):2825-33. PubMed: 24771135 MGI: J:216527
Hsu DS; Wang HJ; Tai SK; Chou CH; Hsieh CH; Chiu PH; Chen NJ; Yang MH. 2014. Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages. Cancer Cell 26(4):534-48. PubMed: 25314079 MGI: J:217891
Huang L; Zhang R; Wu J; Chen J; Grosjean F; Satlin LH; Klein JD; Sands JM; Striker GE; Tan J; Zheng F. 2011. Increased susceptibility to acute kidney injury due to endoplasmic reticulum stress in mice lacking tumor necrosis factor-alpha and its receptor 1. Kidney Int 79(6):613-23. PubMed: 21150875 MGI: J:186880
Huber SA; Sartini D. 2005. Roles of tumor necrosis factor alpha (TNF-alpha) and the p55 TNF receptor in CD1d induction and coxsackievirus B3-induced myocarditis. J Virol 79(5):2659-65. PubMed: 15708985 MGI: J:96701
Husain S; Abdul Y; Webster C; Chatterjee S; Kesarwani P; Mehrotra S. 2014. Interferon-gamma (IFN-gamma)-mediated retinal ganglion cell death in human tyrosinase T cell receptor transgenic mouse. PLoS One 9(2):e89392. PubMed: 24586745 MGI: J:213830
Jackson HW; Hojilla CV; Weiss A; Sanchez OH; Wood GA; Khokha R. 2015. Timp3 deficient mice show resistance to developing breast cancer. PLoS One 10(3):e0120107. PubMed: 25807548 MGI: J:229619
Jacobs JP; Wu HJ; Benoist C; Mathis D. 2009. IL-17-producing T cells can augment autoantibody-induced arthritis. Proc Natl Acad Sci U S A :. PubMed: 19955422 MGI: J:155519
Jang S; Uematsu S; Akira S; Salgame P. 2004. IL-6 and IL-10 induction from dendritic cells in response to Mycobacterium tuberculosis is predominantly dependent on TLR2-mediated recognition. J Immunol 173(5):3392-7. PubMed: 15322203 MGI: J:92712
Jang SY; Shin YK; Lee HY; Park JY; Suh DJ; Kim JK; Bae YS; Park HT. 2012. Local production of serum amyloid a is implicated in the induction of macrophage chemoattractants in Schwann cells during wallerian degeneration of peripheral nerves. Glia 60(10):1619-28. PubMed: 22777957 MGI: J:186481
Jaquemar D; Kupriyanov S; Wankell M; Avis J; Benirschke K; Baribault H; Oshima RG. 2003. Keratin 8 protection of placental barrier function. J Cell Biol 161(4):749-56. PubMed: 12771125 MGI: J:121811
Jayaraman P; Sada-Ovalle I; Nishimura T; Anderson AC; Kuchroo VK; Remold HG; Behar SM. 2013. IL-1beta Promotes Antimicrobial Immunity in Macrophages by Regulating TNFR Signaling and Caspase-3 Activation. J Immunol 190(8):4196-204. PubMed: 23487424 MGI: J:195120
Ji H; Pettit A; Ohmura K; Ortiz-Lopez A; Duchatelle V; Degott C; Gravallese E; Mathis D; Benoist C. 2002. Critical roles for interleukin 1 and tumor necrosis factor alpha in antibody-induced arthritis. J Exp Med 196(1):77-85. PubMed: 12093872 MGI: J:132920
Johansen C; Mose M; Ommen P; Bertelsen T; Vinter H; Hailfinger S; Lorscheid S; Schulze-Osthoff K; Iversen L. 2015. IkappaBzeta is a key driver in the development of psoriasis. Proc Natl Acad Sci U S A 112(43):E5825-33. PubMed: 26460049 MGI: J:227182
Johansen C; Vestergaard C; Kragballe K; Kollias G; Gaestel M; Iversen L. 2009. MK2 regulates the early stages of skin tumor promotion. Carcinogenesis 30(12):2100-8. PubMed: 19808857 MGI: J:155222
Jones-Hall YL; Kozik A; Nakatsu C. 2015. Ablation of tumor necrosis factor is associated with decreased inflammation and alterations of the microbiota in a mouse model of inflammatory bowel disease. PLoS One 10(3):e0119441. PubMed: 25775453 MGI: J:228400
Joosten LA; Smeets RL; Koenders MI; van den Bersselaar LA; Helsen MM; Oppers-Walgreen B; Lubberts E; Iwakura Y; van de Loo FA; van den Berg WB. 2004. Interleukin-18 promotes joint inflammation and induces interleukin-1-driven cartilage destruction. Am J Pathol 165(3):959-67. PubMed: 15331419 MGI: J:92417
Kaiser WJ; Daley-Bauer LP; Thapa RJ; Mandal P; Berger SB; Huang C; Sundararajan A; Guo H; Roback L; Speck SH; Bertin J; Gough PJ; Balachandran S; Mocarski ES. 2014. RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition. Proc Natl Acad Sci U S A 111(21):7753-8. PubMed: 24821786 MGI: J:211029
Kamphuis E; Junt T; Waibler Z; Forster R; Kalinke U. 2006. Type I interferons directly regulate lymphocyte recirculation and cause transient blood lymphopenia. Blood 108(10):3253-61. PubMed: 16868248 MGI: J:140450
Kanehiro A; Lahn M; Makela MJ; Dakhama A; Fujita M; Joetham A; Mason RJ; Born W; Gelfand EW. 2001. Tumor necrosis factor-alpha negatively regulates airway hyperresponsiveness through gamma-delta T cells. Am J Respir Crit Care Med 164(12):2229-38. PubMed: 11751192 MGI: J:132387
Kaneko M; Stellwagen D; Malenka RC; Stryker MP. 2008. Tumor necrosis factor-alpha mediates one component of competitive, experience-dependent plasticity in developing visual cortex. Neuron 58(5):673-80. PubMed: 18549780 MGI: J:145367
Kang HS; Blink SE; Chin RK; Lee Y; Kim O; Weinstock J; Waldschmidt T; Conrad D; Chen B; Solway J; Sperling AI; Fu YX. 2003. Lymphotoxin is required for maintaining physiological levels of serum IgE that minimizes Th1-mediated airway inflammation. J Exp Med 198(11):1643-52. PubMed: 14638845 MGI: J:86810
Kassiotis G; Kollias G. 2001. Uncoupling the Proinflammatory from the Immunosuppressive Properties of Tumor Necrosis Factor (TNF) at the p55 TNF Receptor Level. Implications for pathogenesis and therapy of autoimmune demyelination. J Exp Med 193(4):427-34. PubMed: 11181695 MGI: J:67610
Kassiotis G; Kranidioti K; Kollias G. 2001. Defective CD4T cell priming and resistance to experimental autoimmune encephalomyelitis in TNF-deficient mice due to innate immune hypo-responsiveness. J Neuroimmunol 119(2):239-47. PubMed: 11585627 MGI: J:103105
Kassiotis G; Pasparakis M; Kollias G; Probert L. 1999. TNF accelerates the onset but does not alter the incidence and severity of myelin basic protein-induced experimental autoimmune encephalomyelitis. Eur J Immunol 29(3):774-80. PubMed: 10092079 MGI: J:53472
Kassiri Z; Oudit GY; Kandalam V; Awad A; Wang X; Ziou X; Maeda N; Herzenberg AM; Scholey JW. 2009. Loss of TIMP3 enhances interstitial nephritis and fibrosis. J Am Soc Nephrol 20(6):1223-35. PubMed: 19406980 MGI: J:164969
Kassiri Z; Oudit GY; Sanchez O; Dawood F; Mohammed FF; Nuttall RK; Edwards DR; Liu PP; Backx PH; Khokha R. 2005. Combination of tumor necrosis factor-alpha ablation and matrix metalloproteinase inhibition prevents heart failure after pressure overload in tissue inhibitor of metalloproteinase-3 knock-out mice. Circ Res 97(4):380-90. PubMed: 16037568 MGI: J:112033
Keller C; Keller P; Giralt M; Hidalgo J; Pedersen BK. 2004. Exercise normalises overexpression of TNF-alpha in knockout mice. Biochem Biophys Res Commun 321(1):179-82. PubMed: 15358232 MGI: J:91303
Kim S; Takahashi H; Lin WW; Descargues P; Grivennikov S; Kim Y; Luo JL; Karin M. 2009. Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis. Nature 457(7225):102-6. PubMed: 19122641 MGI: J:143870
Kline J; Zhang L; Battaglia L; Cohen KS; Gajewski TF. 2012. Cellular and molecular requirements for rejection of b16 melanoma in the setting of regulatory T cell depletion and homeostatic proliferation. J Immunol 188(6):2630-42. PubMed: 22312128 MGI: J:181862
Ko MK; Saraswathy S; Parikh JG; Rao NA. 2011. The role of TLR4 activation in photoreceptor mitochondrial oxidative stress. Invest Ophthalmol Vis Sci 52(8):5824-35. PubMed: 21666244 MGI: J:181405
Koenders MI; Lubberts E; van de Loo FA; Oppers-Walgreen B; van den Bersselaar L; Helsen MM; Kolls JK; Di Padova FE; Joosten LA; van den Berg WB. 2006. Interleukin-17 acts independently of TNF-alpha under arthritic conditions. J Immunol 176(10):6262-9. PubMed: 16670337 MGI: J:131778
Kontoyiannis D; Kollias G. 2000. Accelerated autoimmunity and lupus nephritis in NZB mice with an engineered heterozygous deficiency in tumor necrosis factor Eur J Immunol 30(7):2038-47. PubMed: 10940893 MGI: J:63512
Kontoyiannis D; Kotlyarov A; Carballo E; Alexopoulou L; Blackshear PJ; Gaestel M; Davis R; Flavell R; Kollias G. 2001. Interleukin-10 targets p38 MAPK to modulate ARE-dependent TNF mRNA translation and limit intestinal pathology. EMBO J 20(14):3760-70. PubMed: 11447117 MGI: J:108402
Kontoyiannis D; Pasparakis M; Pizarro TT; Cominelli F; Kollias G. 1999. Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU- rich elements: implications for joint and gut-associated immunopathologies. Immunity 10(3):387-98. PubMed: 10204494 MGI: J:54056
Kovacic JC; Gupta R; Lee AC; Ma M; Fang F; Tolbert CN; Walts AD; Beltran LE; San H; Chen G; St Hilaire C; Boehm M. 2010. Stat3-dependent acute Rantes production in vascular smooth muscle cells modulates inflammation following arterial injury in mice. J Clin Invest 120(1):303-14. PubMed: 20038813 MGI: J:156693
Kovalenko A; Kim JC; Kang TB; Rajput A; Bogdanov K; Dittrich-Breiholz O; Kracht M; Brenner O; Wallach D. 2009. Caspase-8 deficiency in epidermal keratinocytes triggers an inflammatory skin disease. J Exp Med 206(10):2161-77. PubMed: 19720838 MGI: J:153779
Krabbe G; Minami SS; Etchegaray JI; Taneja P; Djukic B; Davalos D; Le D; Lo I; Zhan L; Reichert MC; Sayed F; Merlini M; Ward ME; Perry DC; Lee SE; Sias A; Parkhurst CN; Gan WB; Akassoglou K; Miller BL; Farese RV Jr; Gan L. 2017. Microglial NFkappaB-TNFalpha hyperactivation induces obsessive-compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia. Proc Natl Acad Sci U S A 114(19):5029-5034. PubMed: 28438992 MGI: J:242226
Kreisel D; Sugimoto S; Zhu J; Nava R; Li W; Okazaki M; Yamamoto S; Ibrahim M; Huang HJ; Toth KA; Ritter JH; Krupnick AS; Miller MJ; Gelman AE. 2011. Emergency granulopoiesis promotes neutrophil-dendritic cell encounters that prevent mouse lung allograft acceptance. Blood 118(23):6172-82. PubMed: 21972291 MGI: J:179092
Kroner A; Greenhalgh AD; Zarruk JG; Passos Dos Santos R; Gaestel M; David S. 2014. TNF and increased intracellular iron alter macrophage polarization to a detrimental M1 phenotype in the injured spinal cord. Neuron 83(5):1098-116. PubMed: 25132469 MGI: J:221542
Kruglov AA; Lampropoulou V; Fillatreau S; Nedospasov SA. 2011. Pathogenic and protective functions of TNF in neuroinflammation are defined by its expression in T lymphocytes and myeloid cells. J Immunol 187(11):5660-70. PubMed: 22058414 MGI: J:179684
Kugler DG; Mittelstadt PR; Ashwell JD; Sher A; Jankovic D. 2013. CD4+ T cells are trigger and target of the glucocorticoid response that prevents lethal immunopathology in toxoplasma infection. J Exp Med 210(10):1919-27. PubMed: 23980098 MGI: J:202852
Kuprash DV; Tumanov AV; Liepinsh DJ; Koroleva EP; Drutskaya MS; Kruglov AA; Shakhov AN; Southon E; Murphy WJ; Tessarollo L; Grivennikov SI; Nedospasov SA. 2005. Novel tumor necrosis factor-knockout mice that lack Peyer's patches. Eur J Immunol 35(5):1592-600. PubMed: 15832287 MGI: J:97783
Lacey D; Hickey P; Arhatari BD; O'Reilly LA; Rohrbeck L; Kiriazis H; Du XJ; Bouillet P. 2015. Spontaneous retrotransposon insertion into TNF 3'UTR causes heart valve disease and chronic polyarthritis. Proc Natl Acad Sci U S A 112(31):9698-703. PubMed: 26195802 MGI: J:226052
Lambertsen KL; Clausen BH; Babcock AA; Gregersen R; Fenger C; Nielsen HH; Haugaard LS; Wirenfeldt M; Nielsen M; Dagnaes-Hansen F; Bluethmann H; Faergeman NJ; Meldgaard M; Deierborg T; Finsen B. 2009. Microglia protect neurons against ischemia by synthesis of tumor necrosis factor. J Neurosci 29(5):1319-30. PubMed: 19193879 MGI: J:155658
Lawrence JW; Wollenberg GK; DeLuca JG. 2001. Tumor necrosis factor alpha is not required for WY14,643-induced cell proliferation. Carcinogenesis 22(3):381-6. PubMed: 11238176 MGI: J:67996
Leclerc M; Naserian S; Pilon C; Thiolat A; Martin GH; Pouchy C; Dominique C; Belkacemi Y; Charlotte F; Maury S; Salomon BL; Cohen JL. 2016. Control of GVHD by regulatory T cells depends on TNF produced by T cells and TNFR2 expressed by regulatory T cells. Blood 128(12):1651-9. PubMed: 27506541 MGI: J:236729
Lee JH; Bullen JW Jr; Stoyneva VL; Mantzoros CS. 2005. Circulating resistin in lean, obese, and insulin-resistant mouse models: lack of association with insulinemia and glycemia. Am J Physiol Endocrinol Metab 288(3):E625-32. PubMed: 15522996 MGI: J:96072
Lee PY; Kumagai Y; Xu Y; Li Y; Barker T; Liu C; Sobel ES; Takeuchi O; Akira S; Satoh M; Reeves WH. 2011. IL-1alpha modulates neutrophil recruitment in chronic inflammation induced by hydrocarbon oil. J Immunol 186(3):1747-54. PubMed: 21191074 MGI: J:168904
Lee PY; Li Y; Kumagai Y; Xu Y; Weinstein JS; Kellner ES; Nacionales DC; Butfiloski EJ; van Rooijen N; Akira S; Sobel ES; Satoh M; Reeves WH. 2009. Type I interferon modulates monocyte recruitment and maturation in chronic inflammation. Am J Pathol 175(5):2023-33. PubMed: 19808647 MGI: J:154704
Leichtle A; Hernandez M; Ebmeyer J; Yamasaki K; Lai Y; Radek K; Choung YH; Euteneuer S; Pak K; Gallo R; Wasserman SI; Ryan AF. 2010. CC chemokine ligand 3 overcomes the bacteriocidal and phagocytic defect of macrophages and hastens recovery from experimental otitis media in TNF-/- mice. J Immunol 184(6):3087-97. PubMed: 20164426 MGI: J:160109
Lewitus GM; Konefal SC; Greenhalgh AD; Pribiag H; Augereau K; Stellwagen D. 2016. Microglial TNF-alpha Suppresses Cocaine-Induced Plasticity and Behavioral Sensitization. Neuron 90(3):483-91. PubMed: 27112496 MGI: J:239474
Lewitus GM; Pribiag H; Duseja R; St-Hilaire M; Stellwagen D. 2014. An adaptive role of TNFalpha in the regulation of striatal synapses. J Neurosci 34(18):6146-55. PubMed: 24790185 MGI: J:210602
Li Y; Li A; Strait K; Zhang H; Nanes MS; Weitzmann MN. 2007. Endogenous TNFalpha lowers maximum peak bone mass and inhibits osteoblastic Smad activation through NF-kappaB. J Bone Miner Res 22(5):646-55. PubMed: 17266397 MGI: J:135519
Liefner M; Siebert H; Sachse T; Michel U; Kollias G; Bruck W. 2000. The role of TNF-alpha during Wallerian degeneration. J Neuroimmunol 108(1-2):147-52. PubMed: 10900348 MGI: J:102968
Ligresti G; Aplin AC; Zorzi P; Morishita A; Nicosia RF. 2011. Macrophage-derived tumor necrosis factor-alpha is an early component of the molecular cascade leading to angiogenesis in response to aortic injury. Arterioscler Thromb Vasc Biol 31(5):1151-9. PubMed: 21372301 MGI: J:191480
Lin AE; Ebert G; Ow Y; Preston SP; Toe JG; Cooney JP; Scott HW; Sasaki M; Saibil SD; Dissanayake D; Kim RH; Wakeham A; You-Ten A; Shahinian A; Duncan G; Silvester J; Ohashi PS; Mak TW; Pellegrini M. 2013. ARIH2 is essential for embryogenesis, and its hematopoietic deficiency causes lethal activation of the immune system. Nat Immunol 14(1):27-33. PubMed: 23179078 MGI: J:191066
Lin X; Ma X; Rodriguez M; Feng X; Zoecklein L; Fu YX; Roos RP. 2003. Membrane lymphotoxin is required for resistance to Theiler's virus infection. Int Immunol 15(8):955-62. PubMed: 12882833 MGI: J:84938
Lindauer ML; Wong J; Iwakura Y; Magun BE. 2009. Pulmonary inflammation triggered by ricin toxin requires macrophages and IL-1 signaling. J Immunol 183(2):1419-26. PubMed: 19561099 MGI: J:151660
Liu B; Zupan B; Laird E; Klein S; Gleason G; Bozinoski M; Gal Toth J; Toth M. 2014. Maternal hematopoietic TNF, via milk chemokines, programs hippocampal development and memory. Nat Neurosci 17(1):97-105. PubMed: 24292233 MGI: J:207927
Liu J; Zhao MQ; Xu L; Ramana CV; Declercq W; Vandenabeele P; Enelow RI. 2005. Requirement for tumor necrosis factor-receptor 2 in alveolar chemokine expression depends upon the form of the ligand. Am J Respir Cell Mol Biol 33(5):463-9. PubMed: 16081883 MGI: J:115449
Mabbott NA; Williams A; Farquhar CF; Pasparakis M; Kollias G; Bruce ME. 2000. Tumor necrosis factor alpha-deficient, but not interleukin-6-deficient, mice resist peripheral infection with scrapie. J Virol 74(7):3338-44. PubMed: 10708451 MGI: J:126868
Makarenkova V; Chakrabarti AK; Liberatore JA; Popovic P; Lu G; Watkins S; Vujanovic NL. 2005. Dendritic cells and natural killer cells interact via multiple TNF family molecules. J Leukoc Biol 77(3):408-13. PubMed: 15604121 MGI: J:96428
Mandal P; Berger SB; Pillay S; Moriwaki K; Huang C; Guo H; Lich JD; Finger J; Kasparcova V; Votta B; Ouellette M; King BW; Wisnoski D; Lakdawala AS; DeMartino MP; Casillas LN; Haile PA; Sehon CA; Marquis RW; Upton J; Daley-Bauer LP; Roback L; Ramia N; Dovey CM; Carette JE; Chan FK; Bertin J; Gough PJ; Mocarski ES; Kaiser WJ. 2014. RIP3 induces apoptosis independent of pronecrotic kinase activity. Mol Cell 56(4):481-95. PubMed: 25459880 MGI: J:219498
Mann PB; Elder KD; Kennett MJ; Harvill ET. 2004. Toll-like receptor 4-dependent early elicited tumor necrosis factor alpha expression is critical for innate host defense against Bordetella bronchiseptica. Infect Immun 72(11):6650-8. PubMed: 15501798 MGI: J:93263
Matsubara S; Takeda K; Jin N; Okamoto M; Matsuda H; Shiraishi Y; Park JW; McConville G; Joetham A; O'Brien RL; Dakhama A; Born WK; Gelfand EW. 2009. Vgamma1+ T cells and tumor necrosis factor-alpha in ozone-induced airway hyperresponsiveness. Am J Respir Cell Mol Biol 40(4):454-63. PubMed: 18927346 MGI: J:159272
Mayer-Barber KD; Andrade BB; Oland SD; Amaral EP; Barber DL; Gonzales J; Derrick SC; Shi R; Kumar NP; Wei W; Yuan X; Zhang G; Cai Y; Babu S; Catalfamo M; Salazar AM; Via LE; Barry CE 3rd; Sher A. 2014. Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk. Nature 511(7507):99-103. PubMed: 24990750 MGI: J:213640
McLachlan JB; Hart JP; Pizzo SV; Shelburne CP; Staats HF; Gunn MD; Abraham SN. 2003. Mast cell-derived tumor necrosis factor induces hypertrophy of draining lymph nodes during infection. Nat Immunol 4(12):1199-205. PubMed: 14595438 MGI: J:86606
Meng X; Ao L; Song Y; Raeburn CD; Fullerton DA; Harken AH. 2005. Signaling for myocardial depression in hemorrhagic shock: roles of Toll-like receptor 4 and p55 TNF-alpha receptor. Am J Physiol Regul Integr Comp Physiol 288(3):R600-6. PubMed: 15514106 MGI: J:96316
Meng Y; Beckett MA; Liang H; Mauceri HJ; van Rooijen N; Cohen KS; Weichselbaum RR. 2010. Blockade of tumor necrosis factor alpha signaling in tumor-associated macrophages as a radiosensitizing strategy. Cancer Res 70(4):1534-43. PubMed: 20145121 MGI: J:157610
Miller PG; Bonn MB; McKarns SC. 2015. Transmembrane TNF-TNFR2 Impairs Th17 Differentiation by Promoting Il2 Expression. J Immunol 195(6):2633-47. PubMed: 26268655 MGI: J:238596
Mishalian I; Ordan M; Peled A; Maly A; Eichenbaum MB; Ravins M; Aychek T; Jung S; Hanski E. 2011. Recruited macrophages control dissemination of group A Streptococcus from infected soft tissues. J Immunol 187(11):6022-31. PubMed: 22025550 MGI: J:179768
Monraats PS; Pires NM; Schepers A; Agema WR; Boesten LS; de Vries MR; Zwinderman AH; de Maat MP; Doevendans PA; de Winter RJ; Tio RA; Waltenberger J; 't Hart LM; Frants RR; Quax PH; van Vlijmen BJ; Havekes LM; van der Laarse A; van der Wall EE; Jukema JW. 2005. Tumor necrosis factor-alpha plays an important role in restenosis development. FASEB J 19(14):1998-2004. PubMed: 16319143 MGI: J:104664
Moore RJ; Owens DM; Stamp G; Arnott C; Burke F; East N; Holdsworth H; Turner L; Rollins B; Pasparakis M; Kollias G; Balkwill F. 1999. Mice deficient in tumor necrosis factor-alpha are resistant to skin carcinogenesis. Nat Med 5(7):828-831. PubMed: 10395330 MGI: J:56068
Moreland JG; Fuhrman RM; Wohlford-Lenane CL; Quinn TJ; Benda E; Pruessner JA; Schwartz DA. 2001. TNF-alpha and IL-1 beta are not essential to the inflammatory response in LPS-induced airway disease. Am J Physiol Lung Cell Mol Physiol 280(1):L173-80. PubMed: 11133507 MGI: J:107839
Mullarky IK; Szaba FM; Berggren KN; Kummer LW; Wilhelm LB; Parent MA; Johnson LL; Smiley ST. 2006. Tumor necrosis factor alpha and gamma interferon, but not hemorrhage or pathogen burden, dictate levels of protective fibrin deposition during infection. Infect Immun 74(2):1181-8. PubMed: 16428767 MGI: J:104988
Murthy A; Defamie V; Smookler DS; Di Grappa MA; Horiuchi K; Federici M; Sibilia M; Blobel CP; Khokha R. 2010. Ectodomain shedding of EGFR ligands and TNFR1 dictates hepatocyte apoptosis during fulminant hepatitis in mice. J Clin Invest 120(8):2731-44. PubMed: 20628198 MGI: J:163773
Murthy A; Shao YW; Defamie V; Wedeles C; Smookler D; Khokha R. 2012. Stromal TIMP3 Regulates Liver Lymphocyte Populations and Provides Protection against Th1 T Cell-Driven Autoimmune Hepatitis. J Immunol 188(6):2876-83. PubMed: 22323541 MGI: J:181856
Murthy AK; Li W; Chaganty BK; Kamalakaran S; Guentzel MN; Seshu J; Forsthuber TG; Zhong G; Arulanandam BP. 2011. Tumor Necrosis Factor Alpha Production from CD8+ T Cells Mediates Oviduct Pathological Sequelae following Primary Genital Chlamydia muridarum Infection. Infect Immun 79(7):2928-35. PubMed: 21536799 MGI: J:173482
Nadeau S; Filali M; Zhang J; Kerr BJ; Rivest S; Soulet D; Iwakura Y; de Rivero Vaccari JP; Keane RW; Lacroix S. 2011. Functional Recovery after Peripheral Nerve Injury is Dependent on the Pro-Inflammatory Cytokines IL-1{beta} and TNF: Implications for Neuropathic Pain. J Neurosci 31(35):12533-12542. PubMed: 21880915 MGI: J:176222
Nakamura Y; Franchi L; Kambe N; Meng G; Strober W; Nunez G. 2012. Critical role for mast cells in interleukin-1beta-driven skin inflammation associated with an activating mutation in the nlrp3 protein. Immunity 37(1):85-95. PubMed: 22819042 MGI: J:187396
Nakao A; Fukushima H; Kajiya H; Ozeki S; Okabe K. 2007. RANKL-stimulated TNFalpha production in osteoclast precursor cells promotes osteoclastogenesis by modulating RANK signaling pathways. Biochem Biophys Res Commun 357(4):945-50. PubMed: 17467668 MGI: J:121768
Nakazawa T; Kayama M; Ryu M; Kunikata H; Watanabe R; Yasuda M; Kinugawa J; Vavvas D; Miller JW. 2011. Tumor necrosis factor-alpha mediates photoreceptor death in a rodent model of retinal detachment. Invest Ophthalmol Vis Sci 52(3):1384-91. PubMed: 21402953 MGI: J:171495
Nechemia-Arbely Y; Barkan D; Pizov G; Shriki A; Rose-John S; Galun E; Axelrod JH. 2008. IL-6/IL-6R axis plays a critical role in acute kidney injury. J Am Soc Nephrol 19(6):1106-15. PubMed: 18337485 MGI: J:150163
Nenci A; Becker C; Wullaert A; Gareus R; van Loo G; Danese S; Huth M; Nikolaev A; Neufert C; Madison B; Gumucio D; Neurath MF; Pasparakis M. 2007. Epithelial NEMO links innate immunity to chronic intestinal inflammation. Nature 446(7135):557-61. PubMed: 17361131 MGI: J:120854
Neurath MF; Fuss I; Pasparakis M; Alexopoulou L; Haralambous S ; Meyer zum Buschenfelde KH ; Strober W ; Kollias G. 1997. Predominant pathogenic role of tumor necrosis factor in experimental colitis in mice. Eur J Immunol 27(7):1743-50. PubMed: 9247586 MGI: J:41489
Nie S; Cornberg M; Selin LK. 2009. Resistance to vaccinia virus is less dependent on TNF under conditions of heterologous immunity. J Immunol 183(10):6554-60. PubMed: 19846867 MGI: J:157185
Nilsson-Ohman J; Fredrikson GN; Nilsson-Berglund LM; Gustavsson C; Bengtsson E; Smith ML; Agardh CD; Agardh E; Jovinge S; Gomez MF; Nilsson J. 2009. Tumor necrosis factor-alpha does not mediate diabetes-induced vascular inflammation in mice. Arterioscler Thromb Vasc Biol 29(10):1465-70. PubMed: 19755528 MGI: J:167795
Nowak M; Gaines GC; Rosenberg J; Minter R; Bahjat FR; Rectenwald J; MacKay SL; Edwards CK 3rd; Moldawer LL. 2000. LPS-induced liver injury in D-galactosamine-sensitized mice requires secreted TNF-alpha and the TNF-p55 receptor. Am J Physiol Regul Integr Comp Physiol 278(5):R1202-9. PubMed: 10801288 MGI: J:114276
Oberholzer A; Oberholzer C; Bahjat FR; Edwards CK 3rd; Moldawer LL. 2001. Genetic determinants of lipopolysaccharide and D-galactosamine-mediated hepatocellular apoptosis and lethality. J Endotoxin Res 7(5):375-80. PubMed: 11753206 MGI: J:117350
Ochi A; Nguyen AH; Bedrosian AS; Mushlin HM; Zarbakhsh S; Barilla R; Zambirinis CP; Fallon NC; Rehman A; Pylayeva-Gupta Y; Badar S; Hajdu CH; Frey AB; Bar-Sagi D; Miller G. 2012. MyD88 inhibition amplifies dendritic cell capacity to promote pancreatic carcinogenesis via Th2 cells. J Exp Med 209(9):1671-87. PubMed: 22908323 MGI: J:191814
Ogolla PS; Portillo JA; White CL; Patel K; Lamb B; Sen GC; Subauste CS. 2013. The protein kinase double-stranded RNA-dependent (PKR) enhances protection against disease cause by a non-viral pathogen. PLoS Pathog 9(8):e1003557. PubMed: 23990781 MGI: J:214498
Oldford SA; Haidl ID; Howatt MA; Leiva CA; Johnston B; Marshall JS. 2010. A Critical Role for Mast Cells and Mast Cell-Derived IL-6 in TLR2-Mediated Inhibition of Tumor Growth. J Immunol 185(11):7067-76. PubMed: 21041732 MGI: J:166133
Opata MM; Ye Z; Hollifield M; Garvy BA. 2013. B Cell Production of Tumor Necrosis Factor in Response to Pneumocystis murina Infection in Mice. Infect Immun 81(11):4252-60. PubMed: 24002064 MGI: J:201876
Orinska Z; Maurer M; Mirghomizadeh F; Bulanova E; Metz M; Nashkevich N; Schiemann F; Schulmistrat J; Budagian V; Giron-Michel J; Brandt E; Paus R; Bulfone-Paus S. 2007. IL-15 constrains mast cell-dependent antibacterial defenses by suppressing chymase activities. Nat Med 13(8):927-34. PubMed: 17643110 MGI: J:125124
Osawa Y; Hoshi M; Yasuda I; Saibara T; Moriwaki H; Kozawa O. 2013. Tumor necrosis factor-alpha promotes cholestasis-induced liver fibrosis in the mouse through tissue inhibitor of metalloproteinase-1 production in hepatic stellate cells. PLoS One 8(6):e65251. PubMed: 23755201 MGI: J:204251
Oshima H; Ishikawa T; Yoshida GJ; Naoi K; Maeda Y; Naka K; Ju X; Yamada Y; Minamoto T; Mukaida N; Saya H; Oshima M. 2014. TNF-alpha/TNFR1 signaling promotes gastric tumorigenesis through induction of Noxo1 and Gna14 in tumor cells. Oncogene 33(29):3820-9. PubMed: 23975421 MGI: J:212609
Oshima M; Oshima H; Matsunaga A; Taketo MM. 2005. Hyperplastic gastric tumors with spasmolytic polypeptide-expressing metaplasia caused by tumor necrosis factor-alpha-dependent inflammation in cyclooxygenase-2/microsomal prostaglandin E synthase-1 transgenic mice. Cancer Res 65(20):9147-51. PubMed: 16230370 MGI: J:102372
Oshima T; Lee S; Sato A; Oda S; Hirasawa H; Yamashita T. 2009. TNF-alpha contributes to axonal sprouting and functional recovery following traumatic brain injury. Brain Res 1290:102-10. PubMed: 19616519 MGI: J:157212
Pan W; Yu C; Hsuchou H; Zhang Y; Kastin AJ. 2008. Neuroinflammation facilitates LIF entry into brain: role of TNF. Am J Physiol Cell Physiol 294(6):C1436-42. PubMed: 18385284 MGI: J:136622
Papadopoulos G; Weinberg EO; Massari P; Gibson FC 3rd; Wetzler LM; Morgan EF; Genco CA. 2013. Macrophage-Specific TLR2 Signaling Mediates Pathogen-Induced TNF-Dependent Inflammatory Oral Bone Loss. J Immunol 190(3):1148-57. PubMed: 23264656 MGI: J:192608
Parent MA; Wilhelm LB; Kummer LW; Szaba FM; Mullarky IK; Smiley ST. 2006. Gamma interferon, tumor necrosis factor alpha, and nitric oxide synthase 2, key elements of cellular immunity, perform critical protective functions during humoral defense against lethal pulmonary Yersinia pestis infection. Infect Immun 74(6):3381-6. PubMed: 16714568 MGI: J:109236
Park SW; Chen SW; Kim M; Brown KM; Kolls JK; D'Agati VD; Lee HT. 2011. Cytokines induce small intestine and liver injury after renal ischemia or nephrectomy. Lab Invest 91(1):63-84. PubMed: 20697374 MGI: J:167189
Pasparakis M; Alexopoulou L; Grell M; Pfizenmaier K; Bluethmann H; Kollias G. 1997. Peyer's patch organogenesis is intact yet formation of B lymphocyte follicles is defective in peripheral lymphoid organs of mice deficient for tumor necrosis factor and its 55-kDa receptor [published erratum appears in Proc Natl Acad Sci U S A 1997 Aug 19;94(17):9510] Proc Natl Acad Sci U S A 94(12):6319-23. PubMed: 9177215 MGI: J:40970
Pasparakis M; Kousteni S; Peschon J; Kollias G. 2000. Tumor necrosis factor and the p55TNF receptor are required for optimal development of the marginal sinus and for migration of follicular dendritic cell precursors into splenic follicles. Cell Immunol 201(1):33-41. PubMed: 10805971 MGI: J:62236
Peschon JJ; Torrance DS; Stocking KL; Glaccum MB; Otten C; Willis CR ; Charrier K ; Morrissey PJ ; Ware CB ; Mohler KM. 1998. TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation. J Immunol 160(2):943-52. PubMed: 9551933 MGI: J:45147
Peterson KE; Hughes S; Dimcheff DE; Wehrly K; Chesebro B. 2004. Separate sequences in a murine retroviral envelope protein mediate neuropathogenesis by complementary mechanisms with differing requirements for tumor necrosis factor alpha. J Virol 78(23):13104-12. PubMed: 15542662 MGI: J:94216
Petrovich E; Feigelson SW; Stoler-Barak L; Hatzav M; Solomon A; Bar-Shai A; Ilan N; Li JP; Engelhardt B; Vlodavsky I; Alon R. 2016. Lung ICAM-1 and ICAM-2 support spontaneous intravascular effector lymphocyte entrapment but are not required for neutrophil entrapment or emigration inside endotoxin-inflamed lungs. FASEB J 30(5):1767-78. PubMed: 26823454 MGI: J:239265
Phares TW; Fabis MJ; Brimer CM; Kean RB; Hooper DC. 2007. A peroxynitrite-dependent pathway is responsible for blood-brain barrier permeability changes during a central nervous system inflammatory response: TNF-alpha is neither necessary nor sufficient. J Immunol 178(11):7334-43. PubMed: 17513784 MGI: J:147827
Phulwani NK; Esen N; Syed MM; Kielian T. 2008. TLR2 expression in astrocytes is induced by TNF-alpha- and NF-kappaB-dependent pathways. J Immunol 181(6):3841-9. PubMed: 18768838 MGI: J:139111
Poole JA; Kielian T; Wyatt TA; Gleason AM; Stone J; Palm K; West WW; Romberger DJ. 2011. Organic dust augments nucleotide-binding oligomerization domain expression via an NF-{kappa}B pathway to negatively regulate inflammatory responses. Am J Physiol Lung Cell Mol Physiol 301(3):L296-306. PubMed: 21665963 MGI: J:176330
Probert L. 2015. TNF and its receptors in the CNS: The essential, the desirable and the deleterious effects. Neuroscience 302:2-22. PubMed: 26117714 MGI: J:226284
Ramadan RT; Moyer AL; Callegan MC. 2008. A role for tumor necrosis factor-alpha in experimental Bacillus cereus endophthalmitis pathogenesis. Invest Ophthalmol Vis Sci 49(10):4482-9. PubMed: 18586878 MGI: J:141904
Rebholz B; Haase I; Eckelt B; Paxian S; Flaig MJ; Ghoreschi K; Nedospasov SA; Mailhammer R; Debey-Pascher S; Schultze JL; Weindl G; Forster I; Huss R; Stratis A; Ruzicka T; Rocken M; Pfeffer K; Schmid RM; Rupec RA. 2007. Crosstalk between Keratinocytes and Adaptive Immune Cells in an IkappaBalpha Protein-Mediated Inflammatory Disease of the Skin. Immunity 27(2):296-307. PubMed: 17692539 MGI: J:124343
Rectenwald JE; Moldawer LL; Huber TS; Seeger JM; Ozaki CK. 2000. Direct evidence for cytokine involvement in neointimal hyperplasia. Circulation 102(14):1697-702. PubMed: 11015350 MGI: J:130541
Redente EF; Keith RC; Janssen W; Henson PM; Ortiz LA; Downey GP; Bratton DL; Riches DW. 2014. Tumor necrosis factor-alpha accelerates the resolution of established pulmonary fibrosis in mice by targeting profibrotic lung macrophages. Am J Respir Cell Mol Biol 50(4):825-37. PubMed: 24325577 MGI: J:232081
Ren G; Zhao X; Wang Y; Zhang X; Chen X; Xu C; Yuan ZR; Roberts AI; Zhang L; Zheng B; Wen T; Han Y; Rabson AB; Tischfield JA; Shao C; Shi Y. 2012. CCR2-dependent recruitment of macrophages by tumor-educated mesenchymal stromal cells promotes tumor development and is mimicked by TNFalpha. Cell Stem Cell 11(6):812-24. PubMed: 23168163 MGI: J:194684
Rimkunas VM; Graham MJ; Crooke RM; Liscum L. 2009. TNF-{alpha} plays a role in hepatocyte apoptosis in Niemann-Pick type C liver disease. J Lipid Res 50(2):327-33. PubMed: 18815434 MGI: J:149006
Rowlands DJ; Islam MN; Das SR; Huertas A; Quadri SK; Horiuchi K; Inamdar N; Emin MT; Lindert J; Ten VS; Bhattacharya S; Bhattacharya J. 2011. Activation of TNFR1 ectodomain shedding by mitochondrial Ca2+ determines the severity of inflammation in mouse lung microvessels. J Clin Invest 121(5):1986-99. PubMed: 21519143 MGI: J:173932
Rudick CN; Bryce PJ; Guichelaar LA; Berry RE; Klumpp DJ. 2008. Mast cell-derived histamine mediates cystitis pain. PLoS One 3(5):e2096. PubMed: 18461160 MGI: J:136218
Russell JS; McGee SO; Ip MM; Kuhlmann D; Masso-Welch PA. 2007. Conjugated linoleic acid induces mast cell recruitment during mouse mammary gland stromal remodeling. J Nutr 137(5):1200-7. PubMed: 17449582 MGI: J:121742
Rutschmann S; Hoebe K; Zalevsky J; Du X; Mann N; Dahiyat BI; Steed P; Beutler B. 2006. PanR1, a dominant negative missense allele of the gene encoding TNF-alpha (Tnf), does not impair lymphoid development. J Immunol 176(12):7525-32. PubMed: 16751399 MGI: J:124642
Sade-Feldman M; Kanterman J; Ish-Shalom E; Elnekave M; Horwitz E; Baniyash M. 2013. Tumor Necrosis Factor-alpha Blocks Differentiation and Enhances Suppressive Activity of Immature Myeloid Cells during Chronic Inflammation. Immunity 38(3):541-54. PubMed: 23477736 MGI: J:194905
Salomon R; Hoffmann E; Webster RG. 2007. Inhibition of the cytokine response does not protect against lethal H5N1 influenza infection. Proc Natl Acad Sci U S A 104(30):12479-81. PubMed: 17640882 MGI: J:123301
Sanders CJ; Moore DA 3rd; Williams IR; Gewirtz AT. 2008. Both radioresistant and hemopoietic cells promote innate and adaptive immune responses to flagellin. J Immunol 180(11):7184-92. PubMed: 18490717 MGI: J:136347
Sangaletti S; Tripodo C; Chiodoni C; Guarnotta C; Cappetti B; Casalini P; Piconese S; Parenza M; Guiducci C; Vitali C; Colombo MP. 2012. Neutrophil extracellular traps mediate transfer of cytoplasmic neutrophil antigens to myeloid dendritic cells toward ANCA induction and associated autoimmunity. Blood 120(15):3007-18. PubMed: 22932797 MGI: J:192930
Sangaletti S; Tripodo C; Ratti C; Piconese S; Porcasi R; Salcedo R; Trinchieri G; Colombo MP; Chiodoni C. 2010. Oncogene-driven intrinsic inflammation induces leukocyte production of tumor necrosis factor that critically contributes to mammary carcinogenesis. Cancer Res 70(20):7764-75. PubMed: 20924115 MGI: J:165560
Santello M; Bezzi P; Volterra A. 2011. TNFalpha controls glutamatergic gliotransmission in the hippocampal dentate gyrus. Neuron 69(5):988-1001. PubMed: 21382557 MGI: J:174738
Saraswathy S; Nguyen AM; Rao NA. 2010. The role of TLR4 in photoreceptor {alpha}a crystallin upregulation during early experimental autoimmune uveitis. Invest Ophthalmol Vis Sci 51(7):3680-6. PubMed: 20207969 MGI: J:164096
Sayed BA; Christy AL; Walker ME; Brown MA. 2010. Meningeal mast cells affect early T cell central nervous system infiltration and blood-brain barrier integrity through TNF: a role for neutrophil recruitment? J Immunol 184(12):6891-900. PubMed: 20488789 MGI: J:161131
Schatteman GC; Awad O; Nau E; Wang C; Jiao C; Tomanek RJ; Dunnwald M. 2010. Lin- cells mediate tissue repair by regulating MCP-1/CCL-2. Am J Pathol 177(4):2002-10. PubMed: 20813969 MGI: J:165434
Schmidt C; Hocherl K; Bucher M. 2007. Cytokine-mediated regulation of urea transporters during experimental endotoxemia. Am J Physiol Renal Physiol 292(5):F1479-89. PubMed: 17229673 MGI: J:121446
Schmidt NW; Khanolkar A; Hancox L; Heusel JW; Harty JT. 2012. Perforin plays an unexpected role in regulating T-cell contraction during prolonged Listeria monocytogenes infection. Eur J Immunol 42(3):629-40. PubMed: 22161269 MGI: J:187790
Schubert T; Echtenacher B; Hofstadter F; Mannel DN. 2003. TNF-independent development of transient anemia of chronic disease in a mouse model of protracted septic peritonitis. Lab Invest 83(12):1743-50. PubMed: 14691292 MGI: J:124449
Schwitalla S; Fingerle AA; Cammareri P; Nebelsiek T; Goktuna SI; Ziegler PK; Canli O; Heijmans J; Huels DJ; Moreaux G; Rupec RA; Gerhard M; Schmid R; Barker N; Clevers H; Lang R; Neumann J; Kirchner T; Taketo MM; van den Brink GR; Sansom OJ; Arkan MC; Greten FR. 2013. Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties. Cell 152(1-2):25-38. PubMed: 23273993 MGI: J:197481
Scott KA; Arnott CH; Robinson SC; Moore RJ; Thompson RG; Marshall JF; Balkwill FR. 2004. TNF-alpha regulates epithelial expression of MMP-9 and integrin alphavbeta6 during tumour promotion. A role for TNF-alpha in keratinocyte migration? Oncogene 23(41):6954-66. PubMed: 15273742 MGI: J:93774
Sejas DP; Rani R; Qiu Y; Zhang X; Fagerlie SR; Nakano H; Williams DA; Pang Q. 2007. Inflammatory reactive oxygen species-mediated hemopoietic suppression in Fancc-deficient mice. J Immunol 178(8):5277-87. PubMed: 17404312 MGI: J:145270
Sergerie Y; Rivest S; Boivin G. 2007. Tumor necrosis factor-alpha and interleukin-1 beta play a critical role in the resistance against lethal herpes simplex virus encephalitis. J Infect Dis 196(6):853-60. PubMed: 17703415 MGI: J:145249
Shakhov AN; Lyakhov IG; Tumanov AV; Rubtsov AV; Drutskaya LN; Marino MW; Nedospasov SA. 2000. Gene profiling approach in the analysis of lymphotoxin and TNF deficiencies. J Leukoc Biol 68(1):151-7. PubMed: 10914503 MGI: J:120421
Shi M; Ye Z; Umeshappa KS; Moyana T; Xiang J. 2007. Alpha tumor necrosis factor contributes to CD8(+) T cell survival in the transition phase. Biochem Biophys Res Commun 360(3):702-7. PubMed: 17618911 MGI: J:123025
Shubayev VI; Angert M; Dolkas J; Campana WM; Palenscar K; Myers RR. 2006. TNFalpha-induced MMP-9 promotes macrophage recruitment into injured peripheral nerve. Mol Cell Neurosci 31(3):407-15. PubMed: 16297636 MGI: J:106877
Siebert H; Bruck W. 2003. The role of cytokines and adhesion molecules in axon degeneration after peripheral nerve axotomy: a study in different knockout mice. Brain Res 960(1-2):152-6. PubMed: 12505667 MGI: J:107780
Singh A; Singh A; Bauer SJ; Wheeler DL; Havighurst TC; Kim K; Verma AK. 2016. Genetic deletion of TNFalpha inhibits ultraviolet radiation-induced development of cutaneous squamous cell carcinomas in PKCepsilon transgenic mice via inhibition of cell survival signals. Carcinogenesis 37(1):72-80. PubMed: 26586792 MGI: J:230584
Small CL; Shaler CR; McCormick S; Jeyanathan M; Damjanovic D; Brown EG; Arck P; Jordana M; Kaushic C; Ashkar AA; Xing Z. 2010. Influenza infection leads to increased susceptibility to subsequent bacterial superinfection by impairing NK cell responses in the lung. J Immunol 184(4):2048-56. PubMed: 20083661 MGI: J:159483
Stewart CA; Metheny H; Iida N; Smith L; Hanson M; Steinhagen F; Leighty RM; Roers A; Karp CL; Muller W; Trinchieri G. 2013. Interferon-dependent IL-10 production by Tregs limits tumor Th17 inflammation. J Clin Invest :. PubMed: 24216477 MGI: J:204181
Sugimura T; Yoshimura Y; Komatsu Y. 2015. TNFalpha is required for the production of T-type Ca(2+) channel-dependent long-term potentiation in visual cortex. Neurosci Res 96:37-44. PubMed: 25701075 MGI: J:238882
Suh JH; Gong EY; Hong CY; Park E; Ahn RS; Park KS; Lee K. 2008. Reduced testicular steroidogenesis in tumor necrosis factor-alpha knockout mice. J Steroid Biochem Mol Biol 112(1-3):117-21. PubMed: 18832037 MGI: J:143457
Sun J; Sukhova GK; Wolters PJ; Yang M; Kitamoto S; Libby P; MacFarlane LA; Mallen-St Clair J; Shi GP. 2007. Mast cells promote atherosclerosis by releasing proinflammatory cytokines. Nat Med 13(6):719-24. PubMed: 17546038 MGI: J:125116
Sun J; Sukhova GK; Yang M; Wolters PJ; MacFarlane LA; Libby P; Sun C; Zhang Y; Liu J; Ennis TL; Knispel R; Xiong W; Thompson RW; Baxter BT; Shi GP. 2007. Mast cells modulate the pathogenesis of elastase-induced abdominal aortic aneurysms in mice. J Clin Invest 117(11):3359-68. PubMed: 17932568 MGI: J:127400
Sun L; Zhu LL; Lu P; Yuen T; Li J; Ma R; Baliram R; Moonga SS; Liu P; Zallone A; New MI; Davies TF; Zaidi M. 2013. Genetic confirmation for a central role for TNFalpha in the direct action of thyroid stimulating hormone on the skeleton. Proc Natl Acad Sci U S A 110(24):9891-6. PubMed: 23716650 MGI: J:197402
Sun M; Chen M; Dawood F; Zurawska U; Li JY; Parker T; Kassiri Z; Kirshenbaum LA; Arnold M; Khokha R; Liu PP. 2007. Tumor necrosis factor-alpha mediates cardiac remodeling and ventricular dysfunction after pressure overload state. Circulation 115(11):1398-407. PubMed: 17353445 MGI: J:133044
Takabayshi K; Corr M; Hayashi T; Redecke V; Beck L; Guiney D; Sheppard D; Raz E. 2006. Induction of a homeostatic circuit in lung tissue by microbial compounds. Immunity 24(4):475-87. PubMed: 16618605 MGI: J:113350
Tatum AM; Mylin LM; Bender SJ; Fischer MA; Vigliotti BA; Tevethia MJ; Tevethia SS; Schell TD. 2008. CD8+ T cells targeting a single immunodominant epitope are sufficient for elimination of established SV40 T antigen-induced brain tumors. J Immunol 181(6):4406-17. PubMed: 18768900 MGI: J:142961
Tawfeek H; Bedi B; Li JY; Adams J; Kobayashi T; Weitzmann MN; Kronenberg HM; Pacifici R. 2010. Disruption of PTH receptor 1 in T cells protects against PTH-induced bone loss. PLoS One 5(8):e12290. PubMed: 20808842 MGI: J:208749
Todorov V; Muller M; Schweda F; Kurtz A. 2002. Tumor necrosis factor-alpha inhibits renin gene expression. Am J Physiol Regul Integr Comp Physiol 283(5):R1046-51. PubMed: 12376397 MGI: J:113623
Tomomatsu N; Aoki K; Alles N; Soysa NS; Hussain A; Nakachi H; Kita S; Shimokawa H; Ohya K; Amagasa T. 2009. LPS-induced inhibition of osteogenesis is TNF-alpha dependent in a murine tooth extraction model. J Bone Miner Res 24(10):1770-81. PubMed: 19419299 MGI: J:168666
Torchinsky A; Shepshelovich J; Orenstein H; Zaslavsky Z; Savion S; Carp H; Fain A; Toder V. 2003. TNF-alpha protects embryos exposed to developmental toxicants. Am J Reprod Immunol 49(3):159-68. PubMed: 12797522 MGI: J:102935
Torzewski M; Wenzel P; Kleinert H; Becker C; El-Masri J; Wiese E; Brandt M; Pautz A; Twardowski L; Schmitt E; Munzel T; Reifenberg K. 2012. Chronic inflammatory cardiomyopathy of interferon gamma-overexpressing transgenic mice is mediated by tumor necrosis factor-alpha. Am J Pathol 180(1):73-81. PubMed: 22051774 MGI: J:180192
Turrin NP; Rivest S. 2006. Tumor necrosis factor alpha but not interleukin 1 beta mediates neuroprotection in response to acute nitric oxide excitotoxicity. J Neurosci 26(1):143-51. PubMed: 16399681 MGI: J:234004
Ueda N; Kuki H; Kamimura D; Sawa S; Seino K; Tashiro T; Fushuku K; Taniguchi M; Hirano T; Murakami M. 2006. CD1d-restricted NKT cell activation enhanced homeostatic proliferation of CD8+ T cells in a manner dependent on IL-4. Int Immunol 18(9):1397-404. PubMed: 16914507 MGI: J:113387
Ueki Y; Lin CY; Senoo M; Ebihara T; Agata N; Onji M; Saheki Y; Kawai T; Mukherjee PM; Reichenberger E; Olsen BR. 2007. Increased myeloid cell responses to M-CSF and RANKL cause bone loss and inflammation in SH3BP2 'cherubism' mice. Cell 128(1):71-83. PubMed: 17218256 MGI: J:117880
Urabe H; Terashima T; Lin F; Kojima H; Chan L. 2015. Bone marrow-derived TNF-alpha causes diabetic neuropathy in mice. Diabetologia 58(2):402-10. PubMed: 25399355 MGI: J:219648
Varanasi V; Avanesyan L; Schumann DM; Chervonsky AV. 2012. Cytotoxic mechanisms employed by mouse t cells to destroy pancreatic beta-cells. Diabetes 61(11):2862-70. PubMed: 22773667 MGI: J:190161
Varol C; Vallon-Eberhard A; Elinav E; Aychek T; Shapira Y; Luche H; Fehling HJ; Hardt WD; Shakhar G; Jung S. 2009. Intestinal lamina propria dendritic cell subsets have different origin and functions. Immunity 31(3):502-12. PubMed: 19733097 MGI: J:152689
Vazquez-Torres A; Fantuzzi G; Edwards CK 3rd; Dinarello CA; Fang FC. 2001. Defective localization of the NADPH phagocyte oxidase to Salmonella-containing phagosomes in tumor necrosis factor p55 receptor-deficient macrophages. Proc Natl Acad Sci U S A 98(5):2561-5. PubMed: 11226278 MGI: J:126397
Ventre J; Doebber T; Wu M; MacNaul K; Stevens K; Pasparakis M ; Kollias G ; Moller DE. 1997. Targeted disruption of the tumor necrosis factor-alpha gene: metabolic consequences in obese and nonobese mice. Diabetes 46(9):1526-31. PubMed: 9287059 MGI: J:42579
Vila-del Sol V; Diaz-Munoz MD; Fresno M. 2007. Requirement of tumor necrosis factor alpha and nuclear factor-kappaB in the induction by IFN-gamma of inducible nitric oxide synthase in macrophages. J Leukoc Biol 81(1):272-83. PubMed: 17035338 MGI: J:117247
Vila-del Sol V; Fresno M. 2005. Involvement of TNF and NF-kappa B in the transcriptional control of cyclooxygenase-2 expression by IFN-gamma in macrophages. J Immunol 174(5):2825-33. PubMed: 15728492 MGI: J:97728
Vitner EB; Salomon R; Farfel-Becker T; Meshcheriakova A; Ali M; Klein AD; Platt FM; Cox TM; Futerman AH. 2014. RIPK3 as a potential therapeutic target for Gaucher's disease. Nat Med 20(2):204-8. PubMed: 24441827 MGI: J:206864
Wald O; Weiss ID; Wald H; Shoham H; Bar-Shavit Y; Beider K; Galun E; Weiss L; Flaishon L; Shachar I; Nagler A; Lu B; Gerard C; Gao JL; Mishani E; Farber J; Peled A. 2006. IFN-gamma acts on T cells to induce NK cell mobilization and accumulation in target organs. J Immunol 176(8):4716-29. PubMed: 16585565 MGI: J:131189
Wang X; Wang Q; Yang S; Bucan M; Rich MM; Engisch KL. 2011. Impaired Activity-Dependent Plasticity of Quantal Amplitude at the Neuromuscular Junction of Rab3A Deletion and Rab3A Earlybird Mutant Mice. J Neurosci 31(10):3580-8. PubMed: 21389214 MGI: J:170082
Wang Y; Kawamura N; Schmelzer JD; Schmeichel AM; Low PA. 2008. Decreased peripheral nerve damage after ischemia-reperfusion injury in mice lacking TNF-alpha. J Neurol Sci 267(1-2):107-11. PubMed: 18028959 MGI: J:141554
Wang Y; Wang J; Sun Y; Wu Q; Fu YX. 2001. Complementary effects of TNF and lymphotoxin on the formation of germinal center and follicular dendritic cells J Immunol 166(1):330-7. PubMed: 11123309 MGI: J:66397
Weller K; Foitzik K; Paus R; Syska W; Maurer M. 2006. Mast cells are required for normal healing of skin wounds in mice. FASEB J 20(13):2366-8. PubMed: 16966487 MGI: J:129739
Welz PS; Wullaert A; Vlantis K; Kondylis V; Fernandez-Majada V; Ermolaeva M; Kirsch P; Sterner-Kock A; van Loo G; Pasparakis M. 2011. FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation. Nature 477(7364):330-4. PubMed: 21804564 MGI: J:175865
Wheeler DL; Martin KE; Ness KJ; Li Y; Dreckschmidt NE; Wartman M; Ananthaswamy HN; Mitchell DL; Verma AK. 2004. Protein kinase C epsilon is an endogenous photosensitizer that enhances ultraviolet radiation-induced cutaneous damage and development of squamous cell carcinomas. Cancer Res 64(21):7756-65. PubMed: 15520180 MGI: J:93804
Wheeler MA; Heffner DL; Kim S; Espy SM; Spano AJ; Cleland CL; Deppmann CD. 2014. TNF-alpha/TNFR1 signaling is required for the development and function of primary nociceptors. Neuron 82(3):587-602. PubMed: 24811380 MGI: J:214103
Wilson NS; Duewell P; Yang B; Li Y; Marsters S; Koernig S; Latz E; Maraskovsky E; Morelli AB; Schnurr M; Ashkenazi A. 2014. Inflammasome-dependent and -independent IL-18 production mediates immunity to the ISCOMATRIX adjuvant. J Immunol 192(7):3259-68. PubMed: 24610009 MGI: J:210246
Wojciechowski W; Harris DP; Sprague F; Mousseau B; Makris M; Kusser K; Honjo T; Mohrs K; Mohrs M; Randall T; Lund FE. 2009. Cytokine-producing effector B cells regulate type 2 immunity to H. polygyrus. Immunity 30(3):421-33. PubMed: 19249230 MGI: J:146768
Wolf Y; Shemer A; Polonsky M; Gross M; Mildner A; Yona S; David E; Kim KW; Goldmann T; Amit I; Heikenwalder M; Nedospasov S; Prinz M; Friedman N; Jung S. 2017. Autonomous TNF is critical for in vivo monocyte survival in steady state and inflammation. J Exp Med 214(4):905-917. PubMed: 28330904 MGI: J:241862
Wolfe DN; Mann PB; Buboltz AM; Harvill ET. 2007. Delayed role of tumor necrosis factor- alpha in overcoming the effects of pertussis toxin. J Infect Dis 196(8):1228-36. PubMed: 17955442 MGI: J:141574
Wortzman ME; Lin GH; Watts TH. 2013. Intrinsic TNF/TNFR2 interactions fine-tune the CD8 T cell response to respiratory influenza virus infection in mice. PLoS One 8(7):e68911. PubMed: 23874808 MGI: J:204397
Wright HV; Bailey D; Kashyap M; Kepley CL; Drutskaya MS; Nedospasov SA; Ryan JJ. 2006. IL-3-mediated TNF production is necessary for mast cell development. J Immunol 176(4):2114-21. PubMed: 16455967 MGI: J:129126
Wu Q; Wang Y; Wang J; Hedgeman EO; Browning JL; Fu YX. 1999. The requirement of membrane lymphotoxin for the presence of dendritic cells in lymphoid tissues. J Exp Med 190(5):629-38. PubMed: 10477548 MGI: J:110887
Wuthrich M; Filutowicz HI; Warner T; Klein BS. 2002. Requisite elements in vaccine immunity to Blastomyces dermatitidis: plasticity uncovers vaccine potential in immune-deficient hosts. J Immunol 169(12):6969-76. PubMed: 12471131 MGI: J:118419
Xanthoulea S; Pasparakis M; Kousteni S; Brakebusch C; Wallach D; Bauer J; Lassmann H; Kollias G. 2004. Tumor necrosis factor (TNF) receptor shedding controls thresholds of innate immune activation that balance opposing TNF functions in infectious and inflammatory diseases. J Exp Med 200(3):367-76. PubMed: 15289505 MGI: J:92470
Xiao N; Yin M; Zhang L; Qu X; Du H; Sun X; Mao L; Ren G; Zhang C; Geng Y; An L; Pan J. 2009. Tumor necrosis factor-alpha deficiency retards early fatty-streak lesion by influencing the expression of inflammatory factors in apoE-null mice. Mol Genet Metab 96(4):239-44. PubMed: 19157944 MGI: J:146902
Xiong W; MacTaggart J; Knispel R; Worth J; Persidsky Y; Baxter BT. 2009. Blocking TNF-alpha attenuates aneurysm formation in a murine model. J Immunol 183(4):2741-6. PubMed: 19620291 MGI: J:151559
Xu J; Chakrabarti AK; Tan JL; Ge L; Gambotto A; Vujanovic NL. 2007. Essential role of the TNF-TNFR2 cognate interaction in mouse dendritic cell-natural killer cell crosstalk. Blood 109(8):3333-41. PubMed: 17164346 MGI: J:145343
Xu L; Yoon H; Zhao MQ; Liu J; Ramana CV; Enelow RI. 2004. Cutting edge: pulmonary immunopathology mediated by antigen-specific expression of TNF-alpha by antiviral CD8+ T cells. J Immunol 173(2):721-5. PubMed: 15240656 MGI: J:91920
Yabal M; Muller N; Adler H; Knies N; Gross CJ; Damgaard RB; Kanegane H; Ringelhan M; Kaufmann T; Heikenwalder M; Strasser A; Gross O; Ruland J; Peschel C; Gyrd-Hansen M; Jost PJ. 2014. XIAP Restricts TNF- and RIP3-Dependent Cell Death and Inflammasome Activation. Cell Rep 7(6):1796-808. PubMed: 24882010 MGI: J:211783
Yamakawa I; Kojima H; Terashima T; Katagi M; Oi J; Urabe H; Sanada M; Kawai H; Chan L; Yasuda H; Maegawa H; Kimura H. 2011. Inactivation of TNF-alpha ameliorates diabetic neuropathy in mice. Am J Physiol Endocrinol Metab 301(5):E844-52. PubMed: 21810933 MGI: J:182178
Yamoah K; Brebene A; Baliram R; Inagaki K; Dolios G; Arabi A; Majeed R; Amano H; Wang R; Yanagisawa R; Abe E. 2008. High-Mobility Group Box Proteins Modulate Tumor Necrosis Factor-{alpha} Expression in Osteoclastogenesis via a Novel Deoxyribonucleic Acid Sequence. Mol Endocrinol 22(5):1141-53. PubMed: 18218727 MGI: J:134080
Yan K; Cheng L; Liu P; Liu Z; Zhao S; Zhu W; Wang Q; Wu H; Han D. 2015. Polyinosinic-Polycytidylic Acid Perturbs Ovarian Functions Through Toll-Like Receptor 3-Mediated Tumor Necrosis Factor A Production in Female Mice. Biol Reprod 93(1):11. PubMed: 26040668 MGI: J:224466
Yang CY; Leung PS; Yang GX; Kenny TP; Zhang W; Coppel R; Norman GL; Ansari AA; Mackay IR; Worman HJ; Gershwin ME. 2012. Epitope-specific anti-nuclear antibodies are expressed in a mouse model of primary biliary cirrhosis and are cytokine-dependent. Clin Exp Immunol 168(3):261-7. PubMed: 22519587 MGI: J:184866
Yang J; Park Y; Zhang H; Gao X; Wilson E; Zimmer W; Abbott L; Zhang C. 2009. Role of MCP-1 in tumor necrosis factor-alpha-induced endothelial dysfunction in type 2 diabetic mice. Am J Physiol Heart Circ Physiol 297(4):H1208-16. PubMed: 19666844 MGI: J:154217
Yang S; Zhang LS; Gibboni R; Weiner B; Bao S. 2014. Impaired development and competitive refinement of the cortical frequency map in tumor necrosis factor-alpha-deficient mice. Cereb Cortex 24(7):1956-65. PubMed: 23448874 MGI: J:222463
Yi AK; Yoon H; Park JE; Kim BS; Kim HJ; Martinez-Hernandez A. 2006. CpG DNA-mediated induction of acute liver injury in D-galactosamine-sensitized mice: the mitochondrial apoptotic pathway-dependent death of hepatocytes. J Biol Chem 281(21):15001-12. PubMed: 16554296 MGI: J:113473
Zganiacz A; Santosuosso M; Wang J; Yang T; Chen L; Anzulovic M; Alexander S; Gicquel B; Wan Y; Bramson J; Inman M; Xing Z. 2004. TNF-alpha is a critical negative regulator of type 1 immune activation during intracellular bacterial infection. J Clin Invest 113(3):401-13. PubMed: 14755337 MGI: J:87611
Zhang B; Maris CH; Foell J; Whitmire J; Niu L; Song J; Kwon BS; Vella AT; Ahmed R; Jacob J; Mittler RS. 2007. Immune suppression or enhancement by CD137 T cell costimulation during acute viral infection is time dependent. J Clin Invest 117(10):3029-41. PubMed: 17853940 MGI: J:127406
Zhang H; Park Y; Zhang C. 2010. Coronary and aortic endothelial function affected by feedback between adiponectin and tumor necrosis factor alpha in type 2 diabetic mice. Arterioscler Thromb Vasc Biol 30(11):2156-63. PubMed: 20814014 MGI: J:182099
Zhang H; Zhang J; Ungvari Z; Zhang C. 2009. Resveratrol improves endothelial function: role of TNF{alpha} and vascular oxidative stress. Arterioscler Thromb Vasc Biol 29(8):1164-71. PubMed: 19478208 MGI: J:167814
Zhang J; Alcaide P; Liu L; Sun J; He A; Luscinskas FW; Shi GP. 2011. Regulation of endothelial cell adhesion molecule expression by mast cells, macrophages, and neutrophils. PLoS One 6(1):e14525. PubMed: 21264293 MGI: J:169463
Zhang Y; Zhao J; Lau WB; Jiao LY; Liu B; Yuan Y; Wang X; Gao E; Koch WJ; Ma XL; Wang Y. 2013. Tumor necrosis factor-alpha and lymphotoxin-alpha mediate myocardial ischemic injury via TNF receptor 1, but are cardioprotective when activating TNF receptor 2. PLoS One 8(5):e60227. PubMed: 23704873 MGI: J:200841
Zhao C; Ling Z; Newman MB; Bhatia A; Carvey PM. 2007. TNF-alpha knockout and minocycline treatment attenuates blood-brain barrier leakage in MPTP-treated mice. Neurobiol Dis 26(1):36-46. PubMed: 17234424 MGI: J:119001
Zhao L; Chen J; Liu L; Gao J; Guo B; Zhu B. 2015. Essential role of TNF-alpha in development of spleen fibroblastic reticular cells. Cell Immunol 293(2):130-6. PubMed: 25618740 MGI: J:223841
Zimmerman MA; Selzman CH; Reznikov LL; Miller SA; Raeburn CD; Emmick J; Meng X; Harken AH. 2002. Lack of TNF-alpha attenuates intimal hyperplasia after mouse carotid artery injury Am J Physiol Regul Integr Comp Physiol 283(2):R505-12. PubMed: 12121864 MGI: J:113512
Zinselmeyer BH; Heydari S; Sacristan C; Nayak D; Cammer M; Herz J; Cheng X; Davis SJ; Dustin ML; McGavern DB. 2013. PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis. J Exp Med 210(4):757-74. PubMed: 23530125 MGI: J:198217

Also Known As: TNFα-

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Tnftm1Gkl

Allele Symbol: Tnftm1Gkl

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: Tnftm1Gkl related

Mammalian Phenotype Terms by Genotype

Genotype: Tnftm1Gkl/Tnftm1GklC.129S-Tnftm1Gkl

neoplasm

homeostasis/metabolism phenotype

Genotype: Tnftm1Gkl/Tnftm1Gklinvolves: 129S/SvEv * C57BL/6J

immune system phenotype

hematopoietic system phenotype

Genotype: Tnftm1Gkl/Tnftm1Gklinvolves: 129S/SvEv

immune system phenotype

homeostasis/metabolism phenotype

Genotype: Tnftm1Gkl/Tnftm1GklB6;129S-Tnftm1Gkl/J

cellular phenotype

reproductive system phenotype

endocrine/exocrine gland phenotype

Genotype: Tnftm1Gkl/Tnftm1Gkleither: B6.129-Tnftm1Gkl or (involves: 129/Sv * C57BL/6)

immune system phenotype

hematopoietic system phenotype

Genotype: Tnftm1Gkl/Tnftm1Gklinvolves: 129S/SvEv * C57BL/6

growth/size/body region phenotype

cellular phenotype

adipose tissue phenotype

homeostasis/metabolism phenotype

immune system phenotype

hematopoietic system phenotype

neoplasm

craniofacial phenotype

skeleton phenotype

integument phenotype

References

Additional - Tnftm1Gkl related

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Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200

Live Mouse

Cryorecovery - Pricing

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Also Known As: TNFα^-

Tnf^tm1Gkl

Allele Symbol: Tnf^tm1Gkl

Genotype: Tnf^tm1Gkl related

Genotype: Tnf^tm1Gkl/Tnf^tm1Gkl
C.129S-Tnf^tm1Gkl

Genotype: Tnf^tm1Gkl/Tnf^tm1Gkl
involves: 129S/SvEv * C57BL/6J

Genotype: Tnf^tm1Gkl/Tnf^tm1Gkl
involves: 129S/SvEv

Genotype: Tnf^tm1Gkl/Tnf^tm1Gkl
B6;129S-Tnf^tm1Gkl/J

Genotype: Tnf^tm1Gkl/Tnf^tm1Gkl
either: B6.129-Tnf^tm1Gkl or (involves: 129/Sv * C57BL/6)

Genotype: Tnf^tm1Gkl/Tnf^tm1Gkl
involves: 129S/SvEv * C57BL/6

Additional - Tnf^tm1Gkl related