Mice homozygous for the Cd8atm1Mak targeted mutation are deficient in functional cytotoxic T-cells; however, helper T-cell development and function is comparable to normal.
 In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. This is the case for the strain above. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.

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Mice homozygous for the Cd8atm1Mak targeted mutation may be useful in studies of susceptibility to viral infections and the role of cytotoxic T-cells in immune response.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

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