Homozygotes are viable and fertile and do not display any gross physical abnormalities.  These mice do not elaborate photoreceptor outer segments and synaptic termini, and they lack cone and rod activities as assayed by electroretinograms.  Circadian entrainment activity is attenuated. Protein is not produced as determined by RT-PCR of retinal RNA extracts. This strain may be useful as a model of retinophathy (<i>e.g.</i>, Leber's congenital amaurosis (LCA), cone-rod dystrophy-2 (adCRD2), retinitis pigmentosa (RP)), or circadian rhythm modification.

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Homozygotes for this knock-out mutation exhibit a lack of photoreceptor outer segments and rod and cone activity, and circadian entrainment activity is attenuated.



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