JAX
Mouse Strain Datasheet - 006951
STOCK Notch1tm2Rko/GridJ
Also Known As: Notch1flox
These floxed mutant mice possess loxP sites flanking exon 1 of the Notch1 gene. This strain may be useful for generating tissue-specific conditional mutations for studying the development of a wide range of tissues.
Donating Investigator
Raphael Kopan, Cincinnati Children's Hospital Medical Center
Genetic overview
| Genetic Background | Generation |
|---|---|
|
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Notch1tm2Rko
| Allele Type | Gene Symbol | Gene Name |
|---|---|---|
| Targeted (Conditional ready (e.g. floxed), No functional change) | Notch1 | notch 1 |
Research Applications
- Cell Biology Research
- Developmental Biology Research
- Research Tools
Detailed Description
Mice homozygous for this "floxed" Notch1 allele (fN1) are viable and fertile. In the targeted allele, loxP sites were placed flanking exon 1 of the targeted gene. When these floxed mice are bred to mice expressing Cre recombinase, exon 1 of the targeted gene is deleted in cre-expressing tissue(s) in the cre-positive, homozygous floxed offspring. These conditional knockout mice may be useful in generating tissue-specific mutants for studying the development of a wide range of tissues: for example, when crossed to a strain expressing Cre recombinase primarily in the nervous system (see Stock No. 003771), this mutant strain may be useful in studies of apoptosis in neural development.
When crossed to a strain expressing a differential Cre mediated reporter protein labeling: Notch1 signaling in actively cycling stem/progenitor cells (see Stock No. 006953), this mutant strain may be useful in studies of loss of Notch1 heterozygosity.
When bred to mice carrying Tg(Wnt1-cre)11Rth (Stock No. 009107), Cre recombinase expression in the midbrain and developing neural tube results in postnatal lethality.
Development
A targeting construct was designed to place a loxP-flanked PGK-neo cassette upstream of exon 1 of the targeted gene, as well as a single loxP site in intron 1. The construct was electroporated into 129X1/SvJ-derived RW4 embryonic stem (ES) cells. Correctly targeted ES cells were transiently transfected with a Cre recombinase vector to remove the selection cassette. The resulting ES cells harboring the loxP-flanked exon 1 were injected into blastocysts to generate chimeric mice. Mutant mice were then sent to Dr. Thomas Gridley (The Jackson Laboratory) in 2003 on an unspecified mixed genetic background. These mice were supplied to The Jackson Laboratory Repository in 2007.
Control Suggestions
Selected References
- Yang X; Klein R; Tian X; Cheng HT; Kopan R; Shen J. 2004. Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway. Dev Biol 269(1):81-94. PubMed: 15081359MGI: J:90392
Notch1tm2Rko
Allele Symbol: Notch1tm2Rko
| Allele Name | targeted mutation 2, Raphael Kopan |
|---|---|
| Allele Type | Targeted (Conditional ready (e.g. floxed), No functional change) |
| Allele Synonym(s) | N1f; NICD1fl; Notch1f; Notch1flox; Notch1tm1Shn; fN1 |
| Gene Symbol and Name | Notch1, notch 1 |
| Gene Synonym(s) | 9930111A19Rik; 9930111A19Rik; AOS5; AOVD1; Mis6; Motch A; N1; NOTCH; RIKEN cDNA 9930111A19 gene; TAN1; Tan1; Tan1; hN1; lin-12; translocation-associated Notch |
| Strain of Origin | 129X1/SvJ |
| Chromosome | 2 |
| Molecular Note | LoxP were inserted flanking the first coding exon of the gene. An adjacent loxP flanked neomycin cassette was removed by Cre-mediated recombination in ES cells prior to production of chimeric animals. |
| Mutations Made By | Raphael Kopan, Cincinnati Children's Hospital Medical Center |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Cell Biology Research
- Genes Regulating Growth and Proliferation
- Signal Transduction
- Developmental Biology Research
- Growth Defects
- Research Tools
- Cell Biology Research
- Cre-lox System
- loxP-flanked Sequences
- Developmental Biology Research
- Cre-lox System
Mammalian Phenotype Terms by Genotype
The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain
Genotype: Notch1tm2Rko/Notch1tm3(cre)Rko
involves: 129X1/SvJ * C57BL/6
mortality/aging
- premature death
- life expectancy is significantly reduced in mutants (420 days) compared to wild-type (600 days) (MGI Ref ID J:171829)
neoplasm
- increased hemangioma incidence
- 11/13 mice have hemangiosarcoma/vascular tumors, some of which involve multiple organs including the ovary, testis, skin, lymph node, uterus, and colon; liver is the primary site (82% of mice) (MGI Ref ID J:171829)
vision/eye phenotype
- abnormal cornea morphology
- corneal hyperplasia develops by 2-3 months in all animals (MGI Ref ID J:171829)
- corneal deposits
- mice develop corneal plaques by 2-3 months; this increases in severity with age (MGI Ref ID J:171829)
- corneal vascularization
- normal cornea is replaced by a vascularized epidermis-like structure (MGI Ref ID J:171829)
hematopoietic system phenotype
- abnormal spleen morphology
- marked expansion of the interfollicular compartments is observed (MGI Ref ID J:171829)
- enlarged spleen
- reactive splenomegaly is observed at post mortem (MGI Ref ID J:171829)
- extramedullary hematopoiesis
- observed in the spleen in granulocytic, erythrocytic, and megakaryocytic lineages with no bias in B/T cell lineages (MGI Ref ID J:171829)
liver/biliary system phenotype
- abnormal hepatic cord morphology
- hepatic cords are separated by inflammatory infiltrate (MGI Ref ID J:171829)
- abnormal liver lobule morphology
- liver lobes have irregular contours (MGI Ref ID J:171829)
- abnormal liver morphology
- liver contains numerous reddened large blood filled spaces consistent with occurrence of vascular tumors (MGI Ref ID J:171829)
- abnormal liver parenchyma morphology
- normal parenchyma is replaced either by solid, hypercellular tissue composed of spindle and epithelioid cells interspersed with many vascular channels or by irregular vascular channels lined by cells with scant-to-moderate eosinophilic cytoplasm and round-to-oval nuclei; nuclei of these cells of endothelial origin were hyperchromatic or contained coarse chromatin-to-oval nuclei; nuclei of these cells of endothelial origin were hyperchromatic or contained coarse chromatin (MGI Ref ID J:171829)
- enlarged liver sinusoidal spaces
- (MGI Ref ID J:171829)
- liver inflammation
- dense,chronic inflammatory infiltrates are observed around the bile ducts (MGI Ref ID J:171829)
- pale liver
- on post mortem liver is observed to be pale, with many irregular reddened foci; some patches are almost white (MGI Ref ID J:171829)
cardiovascular system phenotype
- corneal vascularization
- normal cornea is replaced by a vascularized epidermis-like structure (MGI Ref ID J:171829)
- enlarged liver sinusoidal spaces
- (MGI Ref ID J:171829)
- hemoperitoneum
- observed in 6/7 naturally deceased mice (MGI Ref ID J:171829)
- increased angiogenesis
- increased angiogenesis is observed in the ear (MGI Ref ID J:171829)
immune system phenotype
- abnormal spleen morphology
- marked expansion of the interfollicular compartments is observed (MGI Ref ID J:171829)
- enlarged spleen
- reactive splenomegaly is observed at post mortem (MGI Ref ID J:171829)
- liver inflammation
- dense,chronic inflammatory infiltrates are observed around the bile ducts (MGI Ref ID J:171829)
The following phenotype relates to a compound genotype created using this strain
Genotype: Notch1tm2Rko/Notch1tm2Rko Tg(Nes-cre)1Kln/0
involves: 129X1/SvJ * C57BL/6J * SJL
cellular phenotype
- abnormal apoptosis
- at E10 the total number of apoptotic cells and relative percentage of apoptotic cells to progenitor cells in the forebrain-midbrain junction is significantly reduced compared to littermate controls (MGI Ref ID J:90392)
nervous system phenotype
- increased neuron number
- the number of postmitotic neurons is increased in the telencephalon at E11.5 - 12.5 compared to littermate controls (MGI Ref ID J:90392)
Genotype: Notch1tm2Rko/Notch1tm2Rko Tg(Wnt1-cre)11Rth/0
involves: 129X1/SvJ * C57BL/6 * CBA
References
- Yang X; Klein R; Tian X; Cheng HT; Kopan R; Shen J. 2004. Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway. Dev Biol 269(1):81-94. PubMed: 15081359MGI: J:90392
Additional - Notch1tm2Rko related
- Bai S; Kopan R; Zou W; Hilton MJ; Ong CT; Long F; Ross FP; Teitelbaum SL. 2008. NOTCH1 regulates osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblast lineage cells. J Biol Chem 283(10):6509-18. PubMed: 18156632MGI: J:133664
- Bi P; Shan T; Liu W; Yue F; Yang X; Liang XR; Wang J; Li J; Carlesso N; Liu X; Kuang S. 2014. Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity. Nat Med 20(8):911-8. PubMed: 25038826MGI: J:226881
- Boyle SC; Liu Z; Kopan R. 2014. Notch signaling is required for the formation of mesangial cells from a stromal mesenchyme precursor during kidney development. Development 141(2):346-54. PubMed: 24353058MGI: J:206586
- Carulli AJ; Keeley TM; Demitrack ES; Chung J; Maillard I; Samuelson LC. 2015. Notch receptor regulation of intestinal stem cell homeostasis and crypt regeneration. Dev Biol 402(1):98-108. PubMed: 25835502MGI: J:222415
- Del Barrio MG; Taveira-Marques R; Muroyama Y; Yuk DI; Li S; Wines-Samuelson M; Shen J; Smith HK; Xiang M; Rowitch D; Richardson WD. 2007. A regulatory network involving Foxn4, Mash1 and delta-like 4/Notch1 generates V2a and V2b spinal interneurons from a common progenitor pool. Development 134(19):3427-36. PubMed: 17728344MGI: J:128001
- Demehri S ; Kopan R. 2009. Notch signaling in bulge stem cells is not required for selection of hair follicle fate. Development 136(6):891-6. PubMed: 19211676MGI: J:146637
- Demehri S; Liu Z; Lee J; Lin MH; Crosby SD; Roberts CJ; Grigsby PW; Miner JH; Farr AG; Kopan R. 2008. Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity. PLoS Biol 6(5):e123. PubMed: 18507503MGI: J:139386
- Demehri S; Turkoz A; Kopan R. 2009. Epidermal Notch1 loss promotes skin tumorigenesis by impacting the stromal microenvironment. Cancer Cell 16(1):55-66. PubMed: 19573812MGI: J:150340
- Demehri S; Turkoz A; Manivasagam S; Yockey LJ; Turkoz M; Kopan R. 2012. Elevated epidermal thymic stromal lymphopoietin levels establish an antitumor environment in the skin. Cancer Cell 22(4):494-505. PubMed: 23079659MGI: J:192028
- El-Hashash AH; Turcatel G; Al Alam D; Buckley S; Tokumitsu H; Bellusci S; Warburton D. 2011. Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epithelium. Development 138(7):1395-407. PubMed: 21385765MGI: J:171504
- El-Hashash AH; Turcatel G; Varma S; Berika M; Al Alam D; Warburton D. 2012. Eya1 protein phosphatase regulates tight junction formation in lung distal epithelium. J Cell Sci 125(Pt 17):4036-48. PubMed: 22685326MGI: J:198889
- Elyaman W; Bassil R; Bradshaw EM; Orent W; Lahoud Y; Zhu B; Radtke F; Yagita H; Khoury SJ. 2012. Notch receptors and Smad3 signaling cooperate in the induction of interleukin-9-producing T cells. Immunity 36(4):623-34. PubMed: 22503540MGI: J:187328
- Fatima A; Culver A; Culver F; Liu T; Dietz WH; Thomson BR; Hadjantonakis AK; Quaggin SE; Kume T. 2014. Murine Notch1 is required for lymphatic vascular morphogenesis during development. Dev Dyn 243(7):957-64. PubMed: 24659232MGI: J:210971
- Gamrekelashvili J; Giagnorio R; Jussofie J; Soehnlein O; Duchene J; Briseno CG; Ramasamy SK; Krishnasamy K; Limbourg A; Kapanadze T; Ishifune C; Hinkel R; Radtke F; Strobl LJ; Zimber-Strobl U; Napp LC; Bauersachs J; Haller H; Yasutomo K; Kupatt C; Murphy KM; Adams RH; Weber C; Limbourg FP. 2016. Regulation of monocyte cell fate by blood vessels mediated by Notch signalling. Nat Commun 7:12597. PubMed: 27576369MGI: J:241907
- Hatakeyama J; Wakamatsu Y; Nagafuchi A; Kageyama R; Shigemoto R; Shimamura K. 2014. Cadherin-based adhesions in the apical endfoot are required for active Notch signaling to control neurogenesis in vertebrates. Development 141(8):1671-82. PubMed: 24715457MGI: J:208850
- Hilton MJ; Tu X; Wu X; Bai S; Zhao H; Kobayashi T; Kronenberg HM; Teitelbaum SL; Ross FP; Kopan R; Long F. 2008. Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation. Nat Med 14(3):306-14. PubMed: 18297083MGI: J:233142
- Hu B; Wu Z; Bai D; Liu T; Ullenbruch MR; Phan SH. 2015. Mesenchymal Deficiency of Notch1 Attenuates Bleomycin-Induced Pulmonary Fibrosis. Am J Pathol 185(11):3066-75. PubMed: 26358219MGI: J:227011
- Huang Z; Rivas B; Agoulnik AI. 2013. NOTCH1 gain of function in germ cells causes failure of spermatogenesis in male mice. PLoS One 8(7):e71213. PubMed: 23936265MGI: J:204938
- Humphreys R; Zheng W; Prince LS; Qu X; Brown C; Loomes K; Huppert SS; Baldwin S; Goudy S. 2012. Cranial neural crest ablation of Jagged1 recapitulates the craniofacial phenotype of Alagille syndrome patients. Hum Mol Genet 21(6):1374-83. PubMed: 22156581MGI: J:181120
- Huppert SS; Ilagan MX; De Strooper B; Kopan R. 2005. Analysis of Notch Function in Presomitic Mesoderm Suggests a gamma-Secretase-Independent Role for Presenilins in Somite Differentiation. Dev Cell 8(5):677-88. PubMed: 15866159MGI: J:98438
- Ishifune C; Maruyama S; Sasaki Y; Yagita H; Hozumi K; Tomita T; Kishihara K; Yasutomo K. 2014. Differentiation of CD11c+CX3CR1+ cells in the small intestine requires Notch signaling. Proc Natl Acad Sci U S A 111(16):5986-91. PubMed: 24711412MGI: J:208857
- Kaftanovskaya EM; Feng S; Huang Z; Tan Y; Barbara AM; Kaur S; Truong A; Gorlov IP; Agoulnik AI. 2011. Suppression of insulin-like3 receptor reveals the role of beta-catenin and Notch signaling in gubernaculum development. Mol Endocrinol 25(1):170-83. PubMed: 21147849MGI: J:182895
- Kang JA; Kim WS; Park SG. 2014. Notch1 is an important mediator for enhancing of B-cell activation and antibody secretion by Notch ligand. Immunology 143(4):550-9. PubMed: 24913005MGI: J:219445
- Kiernan AE; Cordes R; Kopan R; Gossler A; Gridley T. 2005. The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear. Development 132(19):4353-62. PubMed: 16141228MGI: J:132241
- Klinakis A; Lobry C; Abdel-Wahab O; Oh P; Haeno H; Buonamici S; van De Walle I; Cathelin S; Trimarchi T; Araldi E; Liu C; Ibrahim S; Beran M; Zavadil J; Efstratiadis A; Taghon T; Michor F; Levine RL; Aifantis I. 2011. A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia. Nature 473(7346):230-3. PubMed: 21562564MGI: J:172442
- Kode A; Mosialou I; Manavalan SJ; Rathinam CV; Friedman RA; Teruya-Feldstein J; Bhagat G; Berman E; Kousteni S. 2016. FoxO1-dependent induction of acute myeloid leukemia by osteoblasts in mice. Leukemia 30(1):1-13. PubMed: 26108693MGI: J:230612
- Krebs LT; Starling C; Chervonsky AV; Gridley T. 2010. Notch1 activation in mice causes arteriovenous malformations phenocopied by ephrinB2 and EphB4 mutants. Genesis 48(3):146-50. PubMed: 20101599MGI: J:163061
- Kwon C; Cheng P; King IN; Andersen P; Shenje L; Nigam V; Srivastava D. 2011. Notch post-translationally regulates beta-catenin protein in stem and progenitor cells. Nat Cell Biol 13(10):1244-51. PubMed: 21841793MGI: J:176965
- LeComte MD; Shimada IS; Sherwin C; Spees JL. 2015. Notch1-STAT3-ETBR signaling axis controls reactive astrocyte proliferation after brain injury. Proc Natl Acad Sci U S A 112(28):8726-31. PubMed: 26124113MGI: J:223724
- Lee J; Basak JM; Demehri S; Kopan R. 2007. Bi-compartmental communication contributes to the opposite proliferative behavior of Notch1-deficient hair follicle and epidermal keratinocytes. Development 134(15):2795-806. PubMed: 17611229MGI: J:124114
- Li W; Wu J; Yang J; Sun S; Chai R; Chen ZY; Li H. 2015. Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway. Proc Natl Acad Sci U S A 112(1):166-71. PubMed: 25535395MGI: J:218237
- Liu Z; Brunskill E; Boyle S; Chen S; Turkoz M; Guo Y; Grant R; Kopan R. 2015. Second-generation Notch1 activity-trap mouse line (N1IP::CreHI) provides a more comprehensive map of cells experiencing Notch1 activity. Development 142(6):1193-202. PubMed: 25725069MGI: J:220445
- Liu Z; Brunskill E; Varnum-Finney B; Zhang C; Zhang A; Jay PY; Bernstein I; Morimoto M; Kopan R. 2015. The intracellular domains of Notch1 and Notch2 are functionally equivalent during development and carcinogenesis. Development 142(14):2452-63. PubMed: 26062937MGI: J:224078
- Liu Z; Turkoz A; Jackson EN; Corbo JC; Engelbach JA; Garbow JR; Piwnica-Worms DR; Kopan R. 2011. Notch1 loss of heterozygosity causes vascular tumors and lethal hemorrhage in mice. J Clin Invest 121(2):800-8. PubMed: 21266774MGI: J:171829
- Lizama CO; Hawkins JS; Schmitt CE; Bos FL; Zape JP; Cautivo KM; Borges Pinto H; Rhyner AM; Yu H; Donohoe ME; Wythe JD; Zovein AC. 2015. Repression of arterial genes in hemogenic endothelium is sufficient for haematopoietic fate acquisition. Nat Commun 6:7739. PubMed: 26204127MGI: J:224446
- Maekawa Y; Ishifune C; Tsukumo S; Hozumi K; Yagita H; Yasutomo K. 2015. Notch controls the survival of memory CD4+ T cells by regulating glucose uptake. Nat Med 21(1):55-61. PubMed: 25501905MGI: J:227943
- Maurer KA; Riesenberg AN; Brown NL. 2014. Notch signaling differentially regulates Atoh7 and Neurog2 in the distal mouse retina. Development 141(16):3243-54. PubMed: 25100656MGI: J:214082
- Morimoto M; Nishinakamura R; Saga Y; Kopan R. 2012. Different assemblies of Notch receptors coordinate the distribution of the major bronchial Clara, ciliated and neuroendocrine cells. Development 139(23):4365-73. PubMed: 23132245MGI: J:190886
- Movahedan A; Afsharkhamseh N; Sagha HM; Shah JR; Milani BY; Milani FY; Logothetis HD; Chan CC; Djalilian AR. 2013. Loss of Notch1 disrupts the barrier repair in the corneal epithelium. PLoS One 8(7):e69113. PubMed: 23874882MGI: J:204394
- Murtomaki A; Uh MK; Choi YK; Kitajewski C; Borisenko V; Kitajewski J; Shawber CJ. 2013. Notch1 functions as a negative regulator of lymphatic endothelial cell differentiation in the venous endothelium. Development 140(11):2365-76. PubMed: 23615281MGI: J:198575
- Murtomaki A; Uh MK; Kitajewski C; Zhao J; Nagasaki T; Shawber CJ; Kitajewski J. 2014. Notch signaling functions in lymphatic valve formation. Development 141(12):2446-51. PubMed: 24917500MGI: J:213874
- Outtz HH; Tattersall IW; Kofler NM; Steinbach N; Kitajewski J. 2011. Notch1 controls macrophage recruitment and Notch signaling is activated at sites of endothelial cell anastomosis during retinal angiogenesis in mice. Blood 118(12):3436-9. PubMed: 21795743MGI: J:177068
- Outtz HH; Wu JK; Wang X; Kitajewski J. 2010. Notch1 deficiency results in decreased inflammation during wound healing and regulates vascular endothelial growth factor receptor-1 and inflammatory cytokine expression in macrophages. J Immunol 185(7):4363-73. PubMed: 20739676MGI: J:164219
- Pan Y; Lin MH; Tian X; Cheng HT; Gridley T; Shen J; Kopan R. 2004. gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis. Dev Cell 7(5):731-43. PubMed: 15525534MGI: J:94517
- Pan Y; Liu Z; Shen J; Kopan R. 2005. Notch1 and 2 cooperate in limb ectoderm to receive an early Jagged2 signal regulating interdigital apoptosis. Dev Biol 286(2):472-82. PubMed: 16169548MGI: J:103603
- Pellegrinet L; Rodilla V; Liu Z; Chen S; Koch U; Espinosa L; Kaestner KH; Kopan R; Lewis J; Radtke F. 2011. Dll1- and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells. Gastroenterology 140(4):1230-1240.e1-7. PubMed: 21238454MGI: J:220446
- Roderick JE; Gonzalez-Perez G; Kuksin CA; Dongre A; Roberts ER; Srinivasan J; Andrzejewski C Jr; Fauq AH; Golde TE; Miele L; Minter LM. 2013. Therapeutic targeting of NOTCH signaling ameliorates immune-mediated bone marrow failure of aplastic anemia. J Exp Med 210(7):1311-29. PubMed: 23733784MGI: J:201337
- Shi J; Fallahi M; Luo JL; Petrie HT. 2011. Nonoverlapping functions for Notch1 and Notch3 during murine steady-state thymic lymphopoiesis. Blood 118(9):2511-9. PubMed: 21768299MGI: J:177089
- Surendran K; Boyle S; Barak H; Kim M; Stomberski C; McCright B; Kopan R. 2010. The contribution of Notch1 to nephron segmentation in the developing kidney is revealed in a sensitized Notch2 background and can be augmented by reducing Mint dosage. Dev Biol 337(2):386-95. PubMed: 19914235MGI: J:157258
- Surendran K; Selassie M; Liapis H; Krigman H; Kopan R. 2010. Reduced Notch signaling leads to renal cysts and papillary microadenomas. J Am Soc Nephrol 21(5):819-32. PubMed: 20378824MGI: J:185938
- Tsao PN; Matsuoka C; Wei SC; Sato A; Sato S; Hasegawa K; Chen HK; Ling TY; Mori M; Cardoso WV; Morimoto M. 2016. Epithelial Notch signaling regulates lung alveolar morphogenesis and airway epithelial integrity. Proc Natl Acad Sci U S A 113(29):8242-7. PubMed: 27364009MGI: J:234401
- Tu X; Chen J; Lim J; Karner CM; Lee SY; Heisig J; Wiese C; Surendran K; Kopan R; Gessler M; Long F. 2012. Physiological notch signaling maintains bone homeostasis via RBPjk and Hey upstream of NFATc1. PLoS Genet 8(3):e1002577. PubMed: 22457635MGI: J:183534
- Turkoz M; Townsend RR; Kopan R. 2016. The Notch Intracellular Domain Has an RBPj-Independent Role during Mouse Hair Follicular Development. J Invest Dermatol 136(6):1106-15. PubMed: 26940862MGI: J:235539
- Wang Y; Wu B; Chamberlain AA; Lui W; Koirala P; Susztak K; Klein D; Taylor V; Zhou B. 2013. Endocardial to myocardial notch-wnt-bmp axis regulates early heart valve development. PLoS One 8(4):e60244. PubMed: 23560082MGI: J:199879
- Wei W; Zeve D; Wang X; Du Y; Tang W; Dechow PC; Graff JM; Wan Y. 2011. Osteoclast progenitors reside in the peroxisome proliferator-activated receptor gamma-expressing bone marrow cell population. Mol Cell Biol 31(23):4692-705. PubMed: 21947280MGI: J:178880
- Xing Y; Li A; Borok Z; Li C; Minoo P. 2012. NOTCH1 is required for regeneration of Clara cells during repair of airway injury. Stem Cells 30(5):946-55. PubMed: 22331706MGI: J:190179
- Xu J; Chi F; Guo T; Punj V; Lee WN; French SW; Tsukamoto H. 2015. NOTCH reprograms mitochondrial metabolism for proinflammatory macrophage activation. J Clin Invest 125(4):1579-90. PubMed: 25798621MGI: J:222272
- Zhang Y; Lam O; Nguyen MT; Ng G; Pear WS; Ai W; Wang IJ; Kao WW; Liu CY. 2013. Mastermind-like transcriptional co-activator-mediated Notch signaling is indispensable for maintaining conjunctival epithelial identity. Development 140(3):594-605. PubMed: 23293291MGI: J:194073
- Zhao C; Guo H; Li J; Myint T; Pittman W; Yang L; Zhong W; Schwartz RJ; Schwarz JJ; Singer HA; Tallquist MD; Wu M. 2014. Numb family proteins are essential for cardiac morphogenesis and progenitor differentiation. Development 141(2):281-95. PubMed: 24335256MGI: J:206589
- Zheng J; Watanabe H; Wines-Samuelson M; Zhao H; Gridley T; Kopan R; Shen J. 2012. Conditional deletion of Notch1 and Notch2 genes in excitatory neurons of postnatal forebrain does not cause neurodegeneration or reduction of Notch mRNAs and proteins. J Biol Chem 287(24):20356-68. PubMed: 22505716MGI: J:198896
- Zhong R; Bao R; Faber PW; Bindokas VP; Bechill J; Lingen MW; Spiotto MT. 2015. Notch1 Activation or Loss Promotes HPV-Induced Oral Tumorigenesis. Cancer Res 75(18):3958-69. PubMed: 26294213MGI: J:224905