Mice homozygous for the high stepper mutation display an abnormal gait in which they pull their rear legs up to the body as they walk. They also draw the rear legs to the belly when picked up by the tail. Electroretinogram recordings are abnormal for all homozygotes on a pure C57BL/6J background or on a (C57BL/6J x CAST/EiJ)F2 background. Histology of the eye shows rosettes and misplaced ganglion cells by approximately 2 weeks of age.
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous | Rorb | RAR-related orphan receptor beta |
Mice homozygous for the high stepper mutation display an abnormal gait in which they pull their rear legs up to the body as they walk. They also draw the rear legs to the belly when picked up by the tail. Electroretinogram recordings are abnormal for all homozygotes on a pure C57BL/6J background or on a (C57BL/6J x CAST/EiJ)F2 background. Histology of the eye shows rosettes and misplaced ganglion cells by approximately 2 weeks of age.
The high stepper mutation arose spontaneously in 2003 in the inbred C57BL/6J colony at The Jackson Laboratory. It has been maintained on the C57BL/6J background ever since, primarily maintained by the backcross-intercross breeding scheme.
Allele Name | high stepper |
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Allele Type | Spontaneous |
Allele Synonym(s) | |
Gene Symbol and Name | Rorb, RAR-related orphan receptor beta |
Gene Synonym(s) | |
Strain of Origin | C57BL/6J |
Chromosome | 19 |
Molecular Note | This spontaneous mutation is an approximately 300 kb duplication from Chromosome 19 19,010,565 bp to 19,336,747 bp (GRCm38), which includes the first exon of this gene. |
When using the C57BL/6J-Rorbhstp/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #006948 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous for hstp |
Frozen Mouse Embryo | C57BL/6J-Rorb<hstp>/J Frozen Embryo | $2595.00 |
Frozen Mouse Embryo | C57BL/6J-Rorb<hstp>/J Frozen Embryo | $2595.00 |
Frozen Mouse Embryo | C57BL/6J-Rorb<hstp>/J Frozen Embryo | $3373.50 |
Frozen Mouse Embryo | C57BL/6J-Rorb<hstp>/J Frozen Embryo | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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