Mice that are homozygous for the floxed targeted mutation are viable, normal in size, and do not display any gross physical or behavioral abnormalities. When bred to a cre-expressing strain, the exon is excised in tissues of the resulting offspring where cre activity is present. The recombined allele generates a truncated GnT-IVb protein lacking a catalytic domain.

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Mgat4bF floxed mice possess loxP sites flanking exons 2-4 of the Mgat4b gene. When bred to a cre-expressing strain, the exon is excised in tissues of the resulting offspring where cre activity is present. The recombined allele generates a truncated GnT-IVb protein lacking a catalytic domain. This strain may be useful for generating conditional mutations in applications related to the regulation of endosomal sorting and autophagy.

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