JAX Mouse Strain Datasheet - 006883

B6.129S7-Ldlr^tm1Her Sod2^tm1Leb/J

Stock No:: 006883 |; LDLR-

Cryo Recovery

Overview

Also Known As: LDLR-, LDLR MnSOD

Mice heterozygous for Sod2^tm1Leb and homozygous for Ldlr^tm1Her may be predisposed to atherosclerosis.

Donating Investigator

Dr. Jan L. Breslow, Rockefeller University

Genetic overview

Genetic Background	Generation

Ldlr^tm1Her

Allele Type	Gene Symbol	Gene Name
Targeted (Null/Knockout)	Ldlr	low density lipoprotein receptor

Allele Type	Gene Symbol	Gene Name
Targeted (Null/Knockout)	Sod2	superoxide dismutase 2, mitochondrial

Research Applications

Cardiovascular Research
Developmental Biology Research
Diabetes and Obesity Research
Metabolism Research
Neurobiology Research
Research Tools

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Base Price

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$2,595.00 Domestic price Cryo Recovery

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Details

Detailed Description

Independently, mice that are homozygous for this MnSOD mutation (Sod2^tm1Leb) allele exhibit postnatal lethality and exhibit anemia, degeneration of neurons in the basal ganglia and brainstem, progressive motor disturbances, and myocardial injury. Individual LDLR homozygous mutants are predisposed to atherosclerosis. When mutant mice are homozygous for both alleles, they die in utero. Mice heterozygous for the Sod2 mutation and homozygous for the LDLR are viable and fertile. The mice may be useful in studies of diabetes, metabolism, hyperglycemia, atherosclerosis, and hypercholesterolemia, and oxidative stress.

Development

The Ldlr^tm1Her mutation was made by Dr. Robert Hammer and Joachim Herz (HHMI, University of Texas Southwestern Medical Center). Briefly, a targeting vector was used to insert a neo cassette into exon 4. The vector was electroporated into 129S7/SvEvBrd-derived AB1 embryonic stem (ES) cells. Chimeric mice were bred to C57BL/6J, and the strain was made congenic on a C57BL/6J genetic background at The Jackson Laboratory (Stock No. 002207). The Sod2^tm1Leb was created by Dr. Russell Lebovitz (Baylor College of Medicine) by replacing exons 1-2 with a PGK-HPRT minigene. The targeting vector was electroporated into 129S7/SvEvBrd-derived AB2.1 and then maintained on a congenic genetic background at The Jackson Laboratory (Stock No. 002973). To generate the double mutant strain, Stock No. 002207 mice were bred with Stock No. 002973 mice in the laboratory of Dr. Jan Breslow at The Rockefeller University. Double mutant mice were then backcrossed to C57BL/6J for approximately 7 generations prior to arrival at The Jackson Laboratory. The donating investigators indicate that 103/104 microsatellite markers indicate C57BL/6J background. The single exception is D17Mit143.2.

Control Suggestions

000664 C57BL/6J

Additional Information

Considerations for Choosing Controls

Genetics

Ldlr^tm1Her

Allele Symbol: Ldlr^tm1Her

Allele Name	targeted mutation 1, Joachim Herz
Allele Type	Targeted (Null/Knockout)
Allele Synonym(s)	LDLR KO; LDLR-; LDLr-KO; LDLr0; LDLrKO; Ldlrtm1Her
Gene Symbol and Name	Ldlr, low density lipoprotein receptor
Gene Synonym(s)	FH; FHC; LDLCQ2; LDLRA
Site of Expression	Immunoblot analysis of liver membranes detected a truncated protein in homozygous mutant animals.
Strain of Origin	129S7/SvEvBrd-Hprt<+>
Chromosome	9
General Note	When used in bone marrow transplant into Ldlr^tm1Her homozygous mice, Abca1^tm1Jdm Abcg1^tm1Dgen homozygous cells accelerate the development of atherosclerosis. (J:130777) Phenotypic Similarity to Human Syndrome: Atherosclerosis, Susceptibility to J:29950, J:225091 in mice fed a high-cholesterol diet.
Molecular Note	Insertion of a neomycin resistance cassette into exon 4. The authors predict that the targeted allele would encode a truncated non-functional protein that will not bind LDL, and that lacks a membrane spanning segment. Immunoblot analysis of liver membranes detected a truncated protein in homozygous mutant animals.
Mutations Made By	Dr. Joachim Herz, Univ of Texas Southwest Med Ctr Dallas

Sod2^tm1Leb

Allele Symbol: Sod2^tm1Leb

Allele Name	targeted mutation 1, Russell M Lebovitz
Allele Type	Targeted (Null/Knockout)
Allele Synonym(s)	SOD2^m1BCM; Sod2^-; Sod2^mlbcm
Gene Symbol and Name	Sod2, superoxide dismutase 2, mitochondrial
Gene Synonym(s)	IPO-B; IPOB; MGC:6144; MNSOD; MVCD6; Mn-SOD; MnSOD; Sod-2; Sod-2; manganese SOD; manganese superoxide dismutase
Strain of Origin	129S7/SvEvBrd-Hprt
Chromosome	17
Molecular Note	A human HPRT minigene driven by the PGK promoter replaced exons 1 and 2, and sequences approximately 500 bp immediately 5' of exon 1. The replaced region encodes the transcription and translation start sites, the mitochondrial targeting sequence, and one of three histidines that bind directly to the manganese cofactor. Northern blot analysis of brain did not detect mRNA in homozygous mutant mice. Enzyme activity assays of heart did not detect active protein in homozygous mutant mice.
Mutations Made By	Dr. Russell Lebovitz, SUMA Partners

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Cardiovascular Research
- Atherosclerosis
- Hypercholesterolemia
- Other
  - altered fat metabolism
Developmental Biology Research
- Embryonic Lethality (Homozygous)
Diabetes and Obesity Research
- Hyperglycemia
Metabolism Research
- Lipid Metabolism
Neurobiology Research
- Metabolic Defects
Research Tools
- Cardiovascular Research
- Diabetes and Obesity Research
- Metabolism Research

Genotype: Ldlr^tm1Her related

Cardiovascular Research
- Atherosclerosis
- Hypercholesterolemia
Metabolism Research
- Lipid Metabolism

Genotype: Sod2^tm1Leb related

Metabolism Research
Neurobiology Research
- Metabolic Defects
- Neurodegeneration

References

Additional References

Ishibashi S; Brown MS; Goldstein JL; Gerard RD; Hammer RE; Herz J. 1993. Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery [see comments] J Clin Invest 92(2):883-93. PubMed: 8349823 MGI: J:37394
Lebovitz RM; Zhang H; Vogel H; Cartwright J Jr; Dionne L; Lu N; Huang S; Matzuk MM. 1996. Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice. Proc Natl Acad Sci U S A 93(18):9782-7. PubMed: 8790408 MGI: J:36148

Additional - Ldlr^tm1Her related

Accad M; Smith SJ; Newland DL; Sanan DA; King LE Jr; Linton MF; Fazio S; Farese RV Jr. 2000. Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA:cholesterol acyltransferase 1 [see comments] J Clin Invest 105(6):711-9. PubMed: 10727439 MGI: J:61147
Adachi H; Kondo T; Koh GY; Nagy A; Oike Y; Araki E. 2011. Angptl4 deficiency decreases serum triglyceride levels in low-density lipoprotein receptor knockout mice and streptozotocin-induced diabetic mice. Biochem Biophys Res Commun 409(2):177-80. PubMed: 21549101 MGI: J:172599
Afek A; Keren G; Harats D; George J. 2001. Whole body hyperthermia accelerates atherogenesis in low-density lipoprotein receptor deficient mice. Exp Mol Pathol 71(1):63-72. PubMed: 11502098 MGI: J:106255
Ahmad PJ; Trcka D; Xue S; Franco C; Speer MY; Giachelli CM; Bendeck MP. 2009. Discoidin domain receptor-1 deficiency attenuates atherosclerotic calcification and smooth muscle cell-mediated mineralization. Am J Pathol 175(6):2686-96. PubMed: 19893047 MGI: J:155320
Ait-Oufella H; Herbin O; Lahoute C; Coatrieux C; Loyer X; Joffre J; Laurans L; Ramkhelawon B; Blanc-Brude O; Karabina S; Girard CA; Payre C; Yamamoto K; Binder CJ; Murakami M; Tedgui A; Lambeau G; Mallat Z. 2013. Group X secreted phospholipase A2 limits the development of atherosclerosis in LDL receptor-null mice. Arterioscler Thromb Vasc Biol 33(3):466-73. PubMed: 23349189 MGI: J:216884
Ait-Oufella H; Kinugawa K; Zoll J; Simon T; Boddaert J; Heeneman S; Blanc-Brude O; Barateau V; Potteaux S; Merval R; Esposito B; Teissier E; Daemen MJ; Leseche G; Boulanger C; Tedgui A; Mallat Z. 2007. Lactadherin deficiency leads to apoptotic cell accumulation and accelerated atherosclerosis in mice. Circulation 115(16):2168-77. PubMed: 17420351 MGI: J:135906
Ait-Oufella H; Pouresmail V; Simon T; Blanc-Brude O; Kinugawa K; Merval R; Offenstadt G; Leseche G; Cohen PL; Tedgui A; Mallat Z. 2008. Defective mer receptor tyrosine kinase signaling in bone marrow cells promotes apoptotic cell accumulation and accelerates atherosclerosis. Arterioscler Thromb Vasc Biol 28(8):1429-31. PubMed: 18467644 MGI: J:159811
Ait-Oufella H; Salomon BL; Potteaux S; Robertson AK; Gourdy P; Zoll J; Merval R; Esposito B; Cohen JL; Fisson S; Flavell RA; Hansson GK; Klatzmann D; Tedgui A; Mallat Z. 2006. Natural regulatory T cells control the development of atherosclerosis in mice. Nat Med 12(2):178-80. PubMed: 16462800 MGI: J:105800
Albrecht C; Preusch MR; Hofmann G; Morris-Rosenfeld S; Blessing E; Rosenfeld ME; Katus HA; Bea F. 2010. Egr-1 deficiency in bone marrow-derived cells reduces atherosclerotic lesion formation in a hyperlipidaemic mouse model. Cardiovasc Res 86(2):321-9. PubMed: 20110335 MGI: J:175882
Alger HM; Brown JM; Sawyer JK; Kelley KL; Shah R; Wilson MD; Willingham MC; Rudel LL. 2010. Inhibition of acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) prevents dietary cholesterol-associated steatosis by enhancing hepatic triglyceride mobilization. J Biol Chem 285(19):14267-74. PubMed: 20231283 MGI: J:162960
Allred KF; Smart EJ; Wilson ME. 2006. Estrogen receptor-alpha mediates gender differences in atherosclerosis induced by HIV protease inhibitors. J Biol Chem 281(3):1419-25. PubMed: 16299001 MGI: J:107322
Altenburg M; Arbones-Mainar J; Johnson L; Wilder J; Maeda N. 2008. Human LDL receptor enhances sequestration of ApoE4 and VLDL remnants on the surface of hepatocytes but not their internalization in mice. Arterioscler Thromb Vasc Biol 28(6):1104-10. PubMed: 18369154 MGI: J:149026
Angeli V; Llodra J; Rong JX; Satoh K; Ishii S; Shimizu T; Fisher EA; Randolph GJ. 2004. Dyslipidemia associated with atherosclerotic disease systemically alters dendritic cell mobilization. Immunity 21(4):561-74. PubMed: 15485633 MGI: J:93917
Anggraeni VY; Emoto N; Yagi K; Mayasari DS; Nakayama K; Izumikawa T; Kitagawa H; Hirata K. 2011. Correlation of C4ST-1 and ChGn-2 expression with chondroitin sulfate chain elongation in atherosclerosis. Biochem Biophys Res Commun 406(1):36-41. PubMed: 21284936 MGI: J:170936
Arai S; Shelton JM; Chen M; Bradley MN; Castrillo A; Bookout AL; Mak PA; Edwards PA; Mangelsdorf DJ; Tontonoz P; Miyazaki T. 2005. A role for the apoptosis inhibitory factor AIM/Spalpha/Api6 in atherosclerosis development. Cell Metab 1(3):201-13. PubMed: 16054063 MGI: J:129845
Aryal B; Rotllan N; Araldi E; Ramirez CM; He S; Chousterman BG; Fenn AM; Wanschel A; Madrigal-Matute J; Warrier N; Martin-Ventura JL; Swirski FK; Suarez Y; Fernandez-Hernando C. 2016. ANGPTL4 deficiency in haematopoietic cells promotes monocyte expansion and atherosclerosis progression. Nat Commun 7:12313. PubMed: 27460411 MGI: J:241166
Aslanian AM; Chapman HA; Charo IF. 2005. Transient role for CD1d-restricted natural killer T cells in the formation of atherosclerotic lesions. Arterioscler Thromb Vasc Biol 25(3):628-32. PubMed: 15591216 MGI: J:110061
Aslanian AM; Charo IF. 2006. Targeted disruption of the scavenger receptor and chemokine CXCL16 accelerates atherosclerosis. Circulation 114(6):583-90. PubMed: 16880330 MGI: J:123851
Ason B; van der Hoorn JW; Chan J; Lee E; Pieterman EJ; Nguyen KK; Di M; Shetterly S; Tang J; Yeh WC; Schwarz M; Jukema JW; Scott R; Wasserman SM; Princen HM; Jackson S. 2014. PCSK9 inhibition fails to alter hepatic LDLR, circulating cholesterol, and atherosclerosis in the absence of ApoE. J Lipid Res 55(11):2370-9. PubMed: 25258384 MGI: J:216603
Asterholm IW; Rutkowski JM; Fujikawa T; Cho YR; Fukuda M; Tao C; Wang ZV; Gupta RK; Elmquist JK; Scherer PE. 2014. Elevated resistin levels induce central leptin resistance and increased atherosclerotic progression in mice. Diabetologia 57(6):1209-18. PubMed: 24623101 MGI: J:210884
Averill MM; Kim EJ; Goodspeed L; Wang S; Subramanian S; Den Hartigh LJ; Tang C; Ding Y; Reardon CA; Getz GS; Chait A. 2014. The apolipoprotein-AI mimetic peptide L4F at a modest dose does not attenuate weight gain, inflammation, or atherosclerosis in LDLR-null mice. PLoS One 9(10):e109252. PubMed: 25286043 MGI: J:223469
Avraham-Davidi I; Ely Y; Pham VN; Castranova D; Grunspan M; Malkinson G; Gibbs-Bar L; Mayseless O; Allmog G; Lo B; Warren CM; Chen TT; Ungos J; Kidd K; Shaw K; Rogachev I; Wan W; Murphy PM; Farber SA; Carmel L; Shelness GS; Iruela-Arispe ML; Weinstein BM; Yaniv K. 2012. ApoB-containing lipoproteins regulate angiogenesis by modulating expression of VEGF receptor 1. Nat Med 18(6):967-73. PubMed: 22581286 MGI: J:187459
Azhar S; Luo Y; Medicherla S; Reaven E. 1999. Upregulation of selective cholesteryl ester uptake pathway in mice with deletion of low-density lipoprotein receptor function. J Cell Physiol 180(2):190-202. PubMed: 10395289 MGI: J:56099
Babaev VR; Chew JD; Ding L; Davis S; Breyer MD; Breyer RM; Oates JA; Fazio S; Linton MF. 2008. Macrophage EP4 deficiency increases apoptosis and suppresses early atherosclerosis. Cell Metab 8(6):492-501. PubMed: 19041765 MGI: J:144376
Babaev VR; Ding L; Reese J; Morrow JD; Breyer MD; Dey SK; Fazio S; Linton MF. 2006. Cyclooxygenase-1 deficiency in bone marrow cells increases early atherosclerosis in apolipoprotein E- and low-density lipoprotein receptor-null mice. Circulation 113(1):108-17. PubMed: 16380543 MGI: J:121507
Babaev VR; Hebron KE; Wiese CB; Toth CL; Ding L; Zhang Y; May JM; Fazio S; Vickers KC; Linton MF. 2014. Macrophage deficiency of Akt2 reduces atherosclerosis in Ldlr null mice. J Lipid Res 55(11):2296-308. PubMed: 25240046 MGI: J:216614
Babaev VR; Ishiguro H; Ding L; Yancey PG; Dove DE; Kovacs WJ; Semenkovich CF; Fazio S; Linton MF. 2007. Macrophage expression of peroxisome proliferator-activated receptor-alpha reduces atherosclerosis in low-density lipoprotein receptor-deficient mice. Circulation 116(12):1404-12. PubMed: 17724261 MGI: J:139843
Babaev VR; Yancey PG; Ryzhov SV; Kon V; Breyer MD; Magnuson MA; Fazio S; Linton MF. 2005. Conditional knockout of macrophage PPARgamma increases atherosclerosis in C57BL/6 and low-density lipoprotein receptor-deficient mice. Arterioscler Thromb Vasc Biol 25(8):1647-53. PubMed: 15947238 MGI: J:114332
Baeyens N; Mulligan-Kehoe MJ; Corti F; Simon DD; Ross TD; Rhodes JM; Wang TZ; Mejean CO; Simons M; Humphrey J; Schwartz MA. 2014. Syndecan 4 is required for endothelial alignment in flow and atheroprotective signaling. Proc Natl Acad Sci U S A 111(48):17308-13. PubMed: 25404299 MGI: J:216650
Baldan A; Pei L; Lee R; Tarr P; Tangirala RK; Weinstein MM; Frank J; Li AC; Tontonoz P; Edwards PA. 2006. Impaired development of atherosclerosis in hyperlipidemic Ldlr-/- and ApoE-/- mice transplanted with Abcg1-/- bone marrow. Arterioscler Thromb Vasc Biol 26(10):2301-7. PubMed: 16888235 MGI: J:128048
Banko NS; McAlpine CS; Venegas-Pino DE; Raja P; Shi Y; Khan MI; Werstuck GH. 2014. Glycogen synthase kinase 3alpha deficiency attenuates atherosclerosis and hepatic steatosis in high fat diet-fed low density lipoprotein receptor-deficient mice. Am J Pathol 184(12):3394-404. PubMed: 25451156 MGI: J:218258
Barish GD; Yu RT; Karunasiri MS; Becerra D; Kim J; Tseng TW; Tai LJ; Leblanc M; Diehl C; Cerchietti L; Miller YI; Witztum JL; Melnick AM; Dent AL; Tangirala RK; Evans RM. 2012. The Bcl6-SMRT/NCoR cistrome represses inflammation to attenuate atherosclerosis. Cell Metab 15(4):554-62. PubMed: 22465074 MGI: J:184208
Barlic J; Murphy PM. 2007. Chemokine regulation of atherosclerosis. J Leukoc Biol 82(2):226-36. PubMed: 17329566 MGI: J:123530
Bartelt A; Bruns OT; Reimer R; Hohenberg H; Ittrich H; Peldschus K; Kaul MG; Tromsdorf UI; Weller H; Waurisch C; Eychmuller A; Gordts PL; Rinninger F; Bruegelmann K; Freund B; Nielsen P; Merkel M; Heeren J. 2011. Brown adipose tissue activity controls triglyceride clearance. Nat Med 17(2):200-5. PubMed: 21258337 MGI: J:168555
Barthwal MK; Anzinger JJ; Xu Q; Bohnacker T; Wymann MP; Kruth HS. 2013. Fluid-phase pinocytosis of native low density lipoprotein promotes murine M-CSF differentiated macrophage foam cell formation. PLoS One 8(3):e58054. PubMed: 23536783 MGI: J:199527
Basak JM; Verghese PB; Yoon H; Kim J; Holtzman DM. 2012. Low-density lipoprotein receptor represents an apolipoprotein E-independent pathway of Abeta uptake and degradation by astrocytes. J Biol Chem 287(17):13959-71. PubMed: 22383525 MGI: J:241474
Bassett CM; Edel AL; Patenaude AF; McCullough RS; Blackwood DP; Chouinard PY; Paquin P; Lamarche B; Pierce GN. 2010. Dietary vaccenic acid has antiatherogenic effects in LDLr-/- mice. J Nutr 140(1):18-24. PubMed: 19923390 MGI: J:155556
Basso F; Amar MJ; Wagner EM; Vaisman B; Paigen B; Santamarina-Fojo S; Remaley AT. 2006. Enhanced ABCG1 expression increases atherosclerosis in LDLr-KO mice on a western diet. Biochem Biophys Res Commun 351(2):398-404. PubMed: 17070501 MGI: J:116554
Basso F; Freeman LA; Ko C; Joyce C; Amar MJ; Shamburek RD; Tansey T; Thomas F; Wu J; Paigen B; Remaley AT; Santamarina-Fojo S; Brewer HB Jr. 2007. Hepatic ABCG5/G8 overexpression reduces apoB-lipoproteins and atherosclerosis when cholesterol absorption is inhibited. J Lipid Res 48(1):114-26. PubMed: 17060690 MGI: J:117682
Bauer RC; Tohyama J; Cui J; Cheng L; Yang J; Zhang X; Ou K; Paschos GK; Zheng XL; Parmacek MS; Rader DJ; Reilly MP. 2015. Knockout of Adamts7, a novel coronary artery disease locus in humans, reduces atherosclerosis in mice. Circulation 131(13):1202-13. PubMed: 25712206 MGI: J:234324
Bavendiek U; Zirlik A; LaClair S; MacFarlane L; Libby P; Schonbeck U. 2005. Atherogenesis in mice does not require CD40 ligand from bone marrow-derived cells. Arterioscler Thromb Vasc Biol 25(6):1244-9. PubMed: 15746436 MGI: J:114293
Becker L; Liu NC; Averill MM; Yuan W; Pamir N; Peng Y; Irwin AD; Fu X; Bornfeldt KE; Heinecke JW. 2012. Unique proteomic signatures distinguish macrophages and dendritic cells. PLoS One 7(3):e33297. PubMed: 22428014 MGI: J:186914
Becker M; Rabe K; Lebherz C; Zugwurst J; Goke B; Parhofer KG; Lehrke M; Broedl UC. 2010. Expression of human chemerin induces insulin resistance in the skeletal muscle but does not affect weight, lipid levels, and atherosclerosis in LDL receptor knockout mice on high-fat diet. Diabetes 59(11):2898-903. PubMed: 20724582 MGI: J:169337
Bell TA 3rd; Kelley K; Wilson MD; Sawyer JK; Rudel LL. 2007. Dietary fat-induced alterations in atherosclerosis are abolished by ACAT2-deficiency in ApoB100 only, LDLr-/- mice. Arterioscler Thromb Vasc Biol 27(6):1396-402. PubMed: 17431188 MGI: J:134910
Berbee JF; Boon MR; Khedoe PP; Bartelt A; Schlein C; Worthmann A; Kooijman S; Hoeke G; Mol IM; John C; Jung C; Vazirpanah N; Brouwers LP; Gordts PL; Esko JD; Hiemstra PS; Havekes LM; Scheja L; Heeren J; Rensen PC. 2015. Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development. Nat Commun 6:6356. PubMed: 25754609 MGI: J:232977
Bernal-Mizrachi C; Weng S; Feng C; Finck BN; Knutsen RH; Leone TC; Coleman T; Mecham RP; Kelly DP; Semenkovich CF. 2003. Dexamethasone induction of hypertension and diabetes is PPAR-alpha dependent in LDL receptor-null mice. Nat Med 9(8):1069-75. PubMed: 12847522 MGI: J:84844
Bernhagen J; Krohn R; Lue H; Gregory JL; Zernecke A; Koenen RR; Dewor M; Georgiev I; Schober A; Leng L; Kooistra T; Fingerle-Rowson G; Ghezzi P; Kleemann R; McColl SR; Bucala R; Hickey MJ; Weber C. 2007. MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment. Nat Med 13(5):587-596. PubMed: 17435771 MGI: J:121807
Bhasin KK; van Nas A; Martin LJ; Davis RC; Devaskar SU; Lusis AJ. 2009. Maternal low-protein diet or hypercholesterolemia reduces circulating essential amino acids and leads to intrauterine growth restriction. Diabetes 58(3):559-66. PubMed: 19073773 MGI: J:146932
Bhatia VK; Yun S; Leung V; Grimsditch DC; Benson GM; Botto MB; Boyle JJ; Haskard DO. 2007. Complement C1q reduces early atherosclerosis in low-density lipoprotein receptor-deficient mice. Am J Pathol 170(1):416-26. PubMed: 17200212 MGI: J:117210
Bi X; Zhu X; Duong M; Boudyguina EY; Wilson MD; Gebre AK; Parks JS. 2013. Liver ABCA1 deletion in LDLrKO mice does not impair macrophage reverse cholesterol transport or exacerbate atherogenesis. Arterioscler Thromb Vasc Biol 33(10):2288-96. PubMed: 23814116 MGI: J:222231
Bi X; Zhu X; Gao C; Shewale S; Cao Q; Liu M; Boudyguina E; Gebre AK; Wilson MD; Brown AL; Parks JS. 2014. Myeloid cell-specific ATP-binding cassette transporter A1 deletion has minimal impact on atherogenesis in atherogenic diet-fed low-density lipoprotein receptor knockout mice. Arterioscler Thromb Vasc Biol 34(9):1888-99. PubMed: 24833800 MGI: J:227105
Bie J; Wang J; Marqueen KE; Osborne R; Kakiyama G; Korzun W; Ghosh SS; Ghosh S. 2013. Liver-specific cholesteryl ester hydrolase deficiency attenuates sterol elimination in the feces and increases atherosclerosis in ldlr-/- mice. Arterioscler Thromb Vasc Biol 33(8):1795-802. PubMed: 23744992 MGI: J:221021
Bie J; Wang J; Yuan Q; Kakiyama G; Ghosh SS; Ghosh S. 2014. Liver-specific transgenic expression of cholesteryl ester hydrolase reduces atherosclerosis in Ldlr-/- mice. J Lipid Res 55(4):729-38. PubMed: 24563511 MGI: J:208896
Bie J; Zhao B; Ghosh S. 2011. Atherosclerotic lesion progression is attenuated by reconstitution with bone marrow from macrophage-specific cholesteryl ester hydrolase transgenic mice. Am J Physiol Regul Integr Comp Physiol 301(4):R967-74. PubMed: 21795638 MGI: J:178811
Bie J; Zhao B; Song J; Ghosh S. 2010. Improved insulin sensitivity in high fat- and high cholesterol-fed Ldlr-/- mice with macrophage-specific transgenic expression of cholesteryl ester hydrolase: role of macrophage inflammation and infiltration into adipose tissue. J Biol Chem 285(18):13630-7. PubMed: 20189995 MGI: J:163056
Bieghs V; Van Gorp PJ; Wouters K; Hendrikx T; Gijbels MJ; van Bilsen M; Bakker J; Binder CJ; Lutjohann D; Staels B; Hofker MH; Shiri-Sverdlov R. 2012. LDL receptor knock-out mice are a physiological model particularly vulnerable to study the onset of inflammation in non-alcoholic fatty liver disease. PLoS One 7(1):e30668. PubMed: 22295101 MGI: J:184219
Bietrix F; Lombardo E; van Roomen CP; Ottenhoff R; Vos M; Rensen PC; Verhoeven AJ; Aerts JM; Groen AK. 2010. Inhibition of glycosphingolipid synthesis induces a profound reduction of plasma cholesterol and inhibits atherosclerosis development in APOE*3 Leiden and low-density lipoprotein receptor-/- mice. Arterioscler Thromb Vasc Biol 30(5):931-7. PubMed: 20167657 MGI: J:175820
Billon-Gales A; Fontaine C; Douin-Echinard V; Delpy L; Berges H; Calippe B; Lenfant F; Laurell H; Guery JC; Gourdy P; Arnal JF. 2009. Endothelial estrogen receptor-alpha plays a crucial role in the atheroprotective action of 17beta-estradiol in low-density lipoprotein receptor-deficient mice. Circulation 120(25):2567-76. PubMed: 19996016 MGI: J:168125
Billon-Gales A; Fontaine C; Filipe C; Douin-Echinard V; Fouque MJ; Flouriot G; Gourdy P; Lenfant F; Laurell H; Krust A; Chambon P; Arnal JF. 2009. The transactivating function 1 of estrogen receptor alpha is dispensable for the vasculoprotective actions of 17beta-estradiol. Proc Natl Acad Sci U S A 106(6):2053-8. PubMed: 19188600 MGI: J:144952
Billon-Gales A; Krust A; Fontaine C; Abot A; Flouriot G; Toutain C; Berges H; Gadeau AP; Lenfant F; Gourdy P; Chambon P; Arnal JF. 2011. Activation function 2 (AF2) of estrogen receptor-alpha is required for the atheroprotective action of estradiol but not to accelerate endothelial healing. Proc Natl Acad Sci U S A 108(32):13311-6. PubMed: 21788522 MGI: J:175619
Binder CJ; Hartvigsen K; Chang MK; Miller M; Broide D; Palinski W; Curtiss LK; Corr M; Witztum JL. 2004. IL-5 links adaptive and natural immunity specific for epitopes of oxidized LDL and protects from atherosclerosis. J Clin Invest 114(3):427-37. PubMed: 15286809 MGI: J:118092
Binder CJ; Horkko S; Dewan A; Chang MK; Kieu EP; Goodyear CS; Shaw PX; Palinski W; Witztum JL; Silverman GJ. 2003. Pneumococcal vaccination decreases atherosclerotic lesion formation: molecular mimicry between Streptococcus pneumoniae and oxidized LDL. Nat Med 9(6):736-43. PubMed: 12740573 MGI: J:83726
Bischoff ED; Daige CL; Petrowski M; Dedman H; Pattison J; Juliano J; Li AC; Schulman IG. 2010. Non-redundant roles for LXRalpha and LXRbeta in atherosclerosis susceptibility in low density lipoprotein receptor knockout mice. J Lipid Res 51(5):900-6. PubMed: 20388921 MGI: J:160160
Bjorkegren JL; Hagg S; Talukdar HA; Foroughi Asl H; Jain RK; Cedergren C; Shang MM; Rossignoli A; Takolander R; Melander O; Hamsten A; Michoel T; Skogsberg J. 2014. Plasma cholesterol-induced lesion networks activated before regression of early, mature, and advanced atherosclerosis. PLoS Genet 10(2):e1004201. PubMed: 24586211 MGI: J:211003
Blasiole DA; Oler AT; Attie AD. 2008. Regulation of ApoB secretion by the low density lipoprotein receptor requires exit from the endoplasmic reticulum and interaction with ApoE or ApoB. J Biol Chem 283(17):11374-81. PubMed: 18272520 MGI: J:136523
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van Gils JM; Derby MC; Fernandes LR; Ramkhelawon B; Ray TD; Rayner KJ; Parathath S; Distel E; Feig JL; Alvarez-Leite JI; Rayner AJ; McDonald TO; O'Brien KD; Stuart LM; Fisher EA; Lacy-Hulbert A; Moore KJ. 2012. The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques. Nat Immunol 13(2):136-43. PubMed: 22231519 MGI: J:181210
van Gils JM; Ramkhelawon B; Fernandes L; Stewart MC; Guo L; Seibert T; Menezes GB; Cara DC; Chow C; Kinane TB; Fisher EA; Balcells M; Alvarez-Leite J; Lacy-Hulbert A; Moore KJ. 2013. Endothelial expression of guidance cues in vessel wall homeostasis dysregulation under proatherosclerotic conditions. Arterioscler Thromb Vasc Biol 33(5):911-9. PubMed: 23430612 MGI: J:218812
van Kampen E; Beaslas O; Hildebrand RB; Lammers B; Van Berkel TJ; Olkkonen VM; Van Eck M. 2014. Orp8 deficiency in bone marrow-derived cells reduces atherosclerotic lesion progression in LDL receptor knockout mice. PLoS One 9(10):e109024. PubMed: 25347070 MGI: J:223099
van Kampen E; Jaminon A; van Berkel TJ; Van Eck M. 2014. Diet-induced (epigenetic) changes in bone marrow augment atherosclerosis. J Leukoc Biol 96(5):833-41. PubMed: 25024399 MGI: J:220135
van Leeuwen M; Kemna MJ; de Winther MP; Boon L; Duijvestijn AM; Henatsch D; Bos NA; Gijbels MJ; Tervaert JW. 2013. Passive immunization with hypochlorite-oxLDL specific antibodies reduces plaque volume in LDL receptor-deficient mice. PLoS One 8(7):e68039. PubMed: 23874490 MGI: J:204410
van Puijvelde GH; Hauer AD; de Vos P; van den Heuvel R; van Herwijnen MJ; van der Zee R; van Eden W; van Berkel TJ; Kuiper J. 2006. Induction of oral tolerance to oxidized low-density lipoprotein ameliorates atherosclerosis. Circulation 114(18):1968-76. PubMed: 17060383 MGI: J:127201
van Stijn CM; Kim J; Barish GD; Tietge UJ; Tangirala RK. 2014. Adiponectin expression protects against angiotensin II-mediated inflammation and accelerated atherosclerosis. PLoS One 9(1):e86404. PubMed: 24466075 MGI: J:225166
van Vlijmen BJ; Rohlmann A; Page ST; Bensadoun A; Bos IS; van Berkel TJ; Havekes LM; Herz J. 1999. An extrahepatic receptor-associated protein-sensitive mechanism is involved in the metabolism of triglyceride-rich lipoproteins. J Biol Chem 274(49):35219-26. PubMed: 10575007 MGI: J:58704
van Vlijmen BJ; van Dijk KW; van't Hof HB; van Gorp PJ; van der Zee A; van der Boom H; Breuer ML; Hofker MH; Havekes LM. 1996. In the absence of endogenous mouse apolipoprotein E, apolipoprotein E*2(Arg-158 --> Cys) transgenic mice develop more severe hyperlipoproteinemia than apolipoprotein E*3-Leiden transgenic mice. J Biol Chem 271(48):30595-602. PubMed: 8940032 MGI: J:37473
van der Hoogt CC; Berbee JF; Espirito Santo SM; Gerritsen G; Krom YD; van der Zee A; Havekes LM; van Dijk KW; Rensen PC. 2006. Apolipoprotein CI causes hypertriglyceridemia independent of the very-low-density lipoprotein receptor and apolipoprotein CIII in mice. Biochim Biophys Acta 1761(2):213-20. PubMed: 16478678 MGI: J:110564

Additional - Sod2^tm1Leb related

Andrews ZB; Horvath TL. 2009. Uncoupling protein-2 regulates lifespan in mice. Am J Physiol Endocrinol Metab 296(4):E621-7. PubMed: 19141680 MGI: J:148135
Asimakis GK; Lick S; Patterson C. 2002. Postischemic recovery of contractile function is impaired in SOD2(+/-) but not SOD1(+/-) mouse hearts. Circulation 105(8):981-6. PubMed: 11864929 MGI: J:103317
Bhattacharya A; Hegazy AN; Deigendesch N; Kosack L; Cupovic J; Kandasamy RK; Hildebrandt A; Merkler D; Kuhl AA; Vilagos B; Schliehe C; Panse I; Khamina K; Baazim H; Arnold I; Flatz L; Xu HC; Lang PA; Aderem A; Takaoka A; Superti-Furga G; Colinge J; Ludewig B; Lohning M; Bergthaler A. 2015. Superoxide Dismutase 1 Protects Hepatocytes from Type I Interferon-Driven Oxidative Damage. Immunity 43(5):974-86. PubMed: 26588782 MGI: J:234575
Chrispell JD; Feathers KL; Kane MA; Kim CY; Brooks M; Khanna R; Kurth I; Hubner CA; Gal A; Mears AJ; Swaroop A; Napoli JL; Sparrow JR; Thompson DA. 2009. Rdh12 activity and effects on retinoid processing in the murine retina. J Biol Chem 284(32):21468-77. PubMed: 19506076 MGI: J:153181
Crane JD; Abadi A; Hettinga BP; Ogborn DI; MacNeil LG; Steinberg GR; Tarnopolsky MA. 2013. Elevated mitochondrial oxidative stress impairs metabolic adaptations to exercise in skeletal muscle. PLoS One 8(12):e81879. PubMed: 24324727 MGI: J:211014
Das KC; Muniyappa H. 2013. Age-dependent mitochondrial energy dynamics in the mice heart: role of superoxide dismutase-2. Exp Gerontol 48(9):947-59. PubMed: 23806974 MGI: J:210210
Dugan LL; You YH; Ali SS; Diamond-Stanic M; Miyamoto S; DeCleves AE; Andreyev A; Quach T; Ly S; Shekhtman G; Nguyen W; Chepetan A; Le TP; Wang L; Xu M; Paik KP; Fogo A; Viollet B; Murphy A; Brosius F; Naviaux RK; Sharma K. 2013. AMPK dysregulation promotes diabetes-related reduction of superoxide and mitochondrial function. J Clin Invest 123(11):4888-99. PubMed: 24135141 MGI: J:204683
Esposito L; Raber J; Kekonius L; Yan F; Yu GQ; Bien-Ly N; Puolivali J; Scearce-Levie K; Masliah E; Mucke L. 2006. Reduction in mitochondrial superoxide dismutase modulates Alzheimer's disease-like pathology and accelerates the onset of behavioral changes in human amyloid precursor protein transgenic mice. J Neurosci 26(19):5167-79. PubMed: 16687508 MGI: J:108685
Fan YY; Zhan Y; Aukema HM; Davidson LA; Zhou L; Callaway E; Tian Y; Weeks BR; Lupton JR; Toyokuni S; Chapkin RS. 2009. Proapoptotic effects of dietary (n-3) fatty acids are enhanced in colonocytes of manganese-dependent superoxide dismutase knockout mice. J Nutr 139(7):1328-32. PubMed: 19458032 MGI: J:149998
Hou Y; Ouyang X; Wan R; Cheng H; Mattson MP; Cheng A. 2012. Mitochondrial superoxide production negatively regulates neural progenitor proliferation and cerebral cortical development. Stem Cells 30(11):2535-47. PubMed: 22949407 MGI: J:194645
Huang TT; Carlson EJ; Raineri I; Gillespie AM; Kozy H; Epstein CJ. 1999. The use of transgenic and mutant mice to study oxygen free radical metabolism Ann N Y Acad Sci 893:95-112. PubMed: 10672232 MGI: J:60488
Jackson RM; Helton ES; Viera L; Ohman T. 1999. Survival, lung injury, and lung protein nitration in heterozygous MnSOD knockout mice in hyperoxia. Exp Lung Res 25(7):631-46. PubMed: 10598322 MGI: J:103295
Joe MK; Nakaya N; Abu-Asab M; Tomarev SI. 2015. Mutated myocilin and heterozygous Sod2 deficiency act synergistically in a mouse model of open-angle glaucoma. Hum Mol Genet 24(12):3322-34. PubMed: 25740847 MGI: J:221189
Kashimshetty R; Desai VG; Kale VM; Lee T; Moland CL; Branham WS; New LS; Chan EC; Younis H; Boelsterli UA. 2009. Underlying mitochondrial dysfunction triggers flutamide-induced oxidative liver injury in a mouse model of idiosyncratic drug toxicity. Toxicol Appl Pharmacol 238(2):150-9. PubMed: 19442681 MGI: J:151453
Kinugawa S; Wang Z; Kaminski PM; Wolin MS; Edwards JG; Kaley G; Hintze TH. 2005. Limited exercise capacity in heterozygous manganese superoxide dismutase gene-knockout mice: roles of superoxide anion and nitric oxide. Circulation 111(12):1480-6. PubMed: 15781740 MGI: J:108992
Kirkland RA; Saavedra GM; Cummings BS; Franklin JL. 2010. Bax regulates production of superoxide in both apoptotic and nonapoptotic neurons: role of caspases. J Neurosci 30(48):16114-27. PubMed: 21123558 MGI: J:166748
Le T; Keithley EM. 2007. Effects of antioxidants on the aging inner ear. Hear Res 226(1-2):194-202. PubMed: 16843623 MGI: J:119972
Lebovitz RM; Zhang H; Vogel H; Cartwright J Jr; Dionne L; Lu N; Huang S; Matzuk MM. 1996. Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice. Proc Natl Acad Sci U S A 93(18):9782-7. PubMed: 8790408 MGI: J:36148
Lee YH; Chung MC; Lin Q; Boelsterli UA. 2008. Troglitazone-induced hepatic mitochondrial proteome expression dynamics in heterozygous Sod2(+/-) mice: two-stage oxidative injury. Toxicol Appl Pharmacol 231(1):43-51. PubMed: 18495193 MGI: J:140073
Liang LP; Patel M. 2004. Mitochondrial oxidative stress and increased seizure susceptibility in Sod2(-/+) mice. Free Radic Biol Med 36(5):542-54. PubMed: 14980699 MGI: J:88798
Matzuk MM; Dionne L; Guo Q; Kumar TR; Lebovitz RM. 1998. Ovarian function in superoxide dismutase 1 and 2 knockout mice. Endocrinology 139(9):4008-11. PubMed: 9724058 MGI: J:64299
Muller FL; Lustgarten MS; Jang Y; Richardson A; Van Remmen H. 2007. Trends in oxidative aging theories. Free Radic Biol Med 43(4):477-503. PubMed: 17640558 MGI: J:123504
Ohashi M; Runge MS; Faraci FM; Heistad DD. 2006. MnSOD deficiency increases endothelial dysfunction in ApoE-deficient mice. Arterioscler Thromb Vasc Biol 26(10):2331-6. PubMed: 16873728 MGI: J:128050
Ong MM; Latchoumycandane C; Boelsterli UA. 2007. Troglitazone-induced hepatic necrosis in an animal model of silent genetic mitochondrial abnormalities. Toxicol Sci 97(1):205-13. PubMed: 17150972 MGI: J:122231
Ong MM; Wang AS; Leow KY; Khoo YM; Boelsterli UA. 2006. Nimesulide-induced hepatic mitochondrial injury in heterozygous Sod2(+/-) mice. Free Radic Biol Med 40(3):420-9. PubMed: 16443156 MGI: J:105443
Reddy VN; Kasahara E; Hiraoka M; Lin LR; Ho YS. 2004. Effects of variation in superoxide dismutases (SOD) on oxidative stress and apoptosis in lens epithelium. Exp Eye Res 79(6):859-68. PubMed: 15642323 MGI: J:115465
Roos CM; Hagler M; Zhang B; Oehler EA; Arghami A; Miller JD. 2013. Transcriptional and phenotypic changes in aorta and aortic valve with aging and MnSOD deficiency in mice. Am J Physiol Heart Circ Physiol 305(10):H1428-39. PubMed: 23997094 MGI: J:204531
Shimasaki Y; Pan N; Messina LM; Li C; Chen K; Liu L; Cooper MP; Vita JA; Keaney JF Jr. 2013. Uncoupling protein 2 impacts endothelial phenotype via p53-mediated control of mitochondrial dynamics. Circ Res 113(7):891-901. PubMed: 23819990 MGI: J:213382
Srivastava S; Banerjee H; Chaudhry A; Khare A; Sarin A; George A; Bal V; Durdik JM; Rath S. 2007. Apoptosis-inducing factor regulates death in peripheral T cells. J Immunol 179(2):797-803. PubMed: 17617569 MGI: J:149344
Xiong Y; Shie FS; Zhang J; Lee CP; Ho YS. 2005. Prevention of mitochondrial dysfunction in post-traumatic mouse brain by superoxide dismutase. J Neurochem 95(3):732-44. PubMed: 16248885 MGI: J:136792
Yan C; Huang A; Wu Z; Kaminski PM; Wolin MS; Hintze TH; Kaley G; Sun D. 2005. Increased superoxide leads to decreased flow-induced dilation in resistance arteries of Mn-SOD-deficient mice. Am J Physiol Heart Circ Physiol 288(5):H2225-31. PubMed: 15637112 MGI: J:98222
Yang D; Elner SG; Lin LR; Reddy VN; Petty HR; Elner VM. 2009. Association of superoxide anions with retinal pigment epithelial cell apoptosis induced by mononuclear phagocytes. Invest Ophthalmol Vis Sci 50(10):4998-5005. PubMed: 19458341 MGI: J:154540
Yoshihara D; Fujiwara N; Ookawara T; Kato S; Sakiyama H; Yokoe S; Eguchi H; Suzuki K. 2009. Protective role of glutathione S-transferase A4 induced in copper/zinc-superoxide dismutase knockout mice. Free Radic Biol Med 47(5):559-67. PubMed: 19482077 MGI: J:151433

Also Known As: LDLR-, LDLR MnSOD

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Ldlrtm1Her

Allele Symbol: Ldlrtm1Her

Sod2tm1Leb

Allele Symbol: Sod2tm1Leb

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This mouse can be used to support research in many areas including:

Genotype: Ldlrtm1Her related

Genotype: Sod2tm1Leb related

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Ldlr^tm1Her

Allele Symbol: Ldlr^tm1Her

Sod2^tm1Leb

Allele Symbol: Sod2^tm1Leb

Genotype: Ldlr^tm1Her related

Genotype: Sod2^tm1Leb related

Additional - Ldlr^tm1Her related

Additional - Sod2^tm1Leb related