JAX
Mouse Strain Datasheet - 006860
B6.Cg-Ins2Akita Bdkrb2tm1Jfh/SmiJ
Also Known As: B6-Akita, B2R, B6-B2R, Akita
Mice homozygous for this targeted mutation of the bradykinin receptor, beta 2 (Bdkrb2) gene and heterozygous for the Akita spontaneous mutation of the insulin 2 (Ins2) gene (Ins2Akita) are viable and fertile. They are extremely diabetic, underweight, hyperphagic, polyuric, and have severe kidney, skeletal, and testicular defects. essentially no subcutaneous fat, and a significantly reduced lifespan. This strain may be used to research the kallikrein-kinin system, specifically the role of bradykinin B2 receptor in diabetes, oxidative stress, mitochondrial DNA damage, apoptosis, kidney morphology and function, and other senescence-associated phenotypes.
Donating Investigator
Dr. Masao Kakoki, University of North Carolina at Chapel H
Genetic overview
| Genetic Background | Generation |
|---|---|
|
000664 C57BL/6J |
|
Bdkrb2tm1Jfh
| Allele Type | Gene Symbol | Gene Name |
|---|---|---|
| Targeted (Null/Knockout) | Bdkrb2 | bradykinin receptor, beta 2 |
Ins2Akita
| Allele Type | Gene Symbol | Gene Name |
|---|---|---|
| Spontaneous | Ins2 | insulin II |
Research Applications
- Apoptosis Research
- Cancer Research
- Diabetes and Obesity Research
- Immunology, Inflammation and Autoimmunity Research
- Internal/Organ Research
- Cardiovascular Research
- Cell Biology Research
- Endocrine Deficiency Research
Detailed Description
Mice homozygous for the targeted mutation and heterozygous for the Ins2Akita spontaneous mutation are viable and fertile. Similar to mice only heterozygous for the Ins2Akita mutation, the double mutant mice are severely diabetic: their body weights are 70% of wildtype, they consume over 3-fold the normal amount of food, and their urinary output is approximately 20-fold more than that of wildtype mice. Double mutant mice have markedly enlarged kidneys. Urinary albumin excretion in double mutants is almost 4-fold that of either single mutant, and double mutants experience more severe nephropathy than mice that are heterozygous for the Akita mutation alone. Megsin and nephrin expression is markedly increased in double mutant mice when compared to wildtype or to mice with either single mutation alone. By 12 months of age, double mutant mice experience hair loss due to a reduction in hair follicle numbers and thinning of the dermis. Double mutants have essentially no subcutaneous fat, severe kyphosis, reduced bone density, osteoporosis, testicular atrophy, lipofuscin accumulation in the renal proximal tubule and testicular Leydig cells, increased apoptosis in the testicular seminiferous tubules and intestinal villi, and a significantly reduced lifespan.
This model is useful for studying the kallikrein-kinin system, specifically the role of bradykinin B2 receptor in diabetes, oxidative stress, mitochondrial DNA damage, apoptosis, morphological and functional kidney changes, and other senescence-associated phenotypes.
Development
Dr. Oliver Smithies laboratory backcrossed Stock No. 002641 B6;129S7-Bdkrb2tm1Jfh/J mice to C57BL/6J (Stock No. 000664) for an additional 6 generations prior to mating to Stock No. 003548 C57BL/6-Ins2Akita/J. In 2007, The Jackson Laboratory received C57BL/6 congenic males homozygous for the Bdkrb2tm1Jfh mutation at N9F? and mated them to heterozygous females from Stock No. 003548 C57BL/6-Ins2Akita/J. The strain has been maintained subsequently by brother x sister matings.
Genetic quality control completed at The Jackson Laboratory indicates that there is 129 genetic contamination on chromosomes 3, 4, 6, 11, 15 and 17 (006860 SNP's marker data)
Control Suggestions
Selected References
- Kakoki M; Kizer CM; Yi X; Takahashi N; Kim HS; Bagnell CR; Edgell CJ; Maeda N; Jennette JC; Smithies O. 2006. Senescence-associated phenotypes in Akita diabetic mice are enhanced by absence of bradykinin B2 receptors. J Clin Invest 116(5):1302-9. PubMed: 16604193MGI: J:108948
- Kakoki M; McGarrah RW; Kim HS; Smithies O. 2007. Bradykinin B1 and B2 receptors both have protective roles in renal ischemia/reperfusion injury. Proc Natl Acad Sci U S A 104(18):7576-81. PubMed: 17452647MGI: J:121339
- Kakoki M; Takahashi N; Jennette JC; Smithies O. 2004. Diabetic nephropathy is markedly enhanced in mice lacking the bradykinin B2 receptor. Proc Natl Acad Sci U S A 101(36):13302-5. PubMed: 15326315MGI: J:92403
Bdkrb2tm1Jfh
Allele Symbol: Bdkrb2tm1Jfh
| Allele Name | targeted mutation 1, J Fred Hess |
|---|---|
| Allele Type | Targeted (Null/Knockout) |
| Allele Synonym(s) | B2-; B2-KO; B2R-; BdkrB2; Bk B2R-; Bk2r-; rB2 - |
| Gene Symbol and Name | Bdkrb2, bradykinin receptor, beta 2 |
| Gene Synonym(s) | B(2); B2; B2BKR; B2BRA; B2R; BK-2; BK2; BK2R; BKR2; BRB2; kinin B2 |
| Strain of Origin | 129S7/SvEvBrd-Hprt |
| Chromosome | 12 |
| Molecular Note | A neomycin selection cassette replaced the entire coding sequences of the gene. Binding assays on membranes prepared from ileum tissue of homozygous mice confirmed that no functional protein is produced from this allele. |
| Mutations Made By | Dr. J. Hess, Merck Research Laboratories |
Ins2Akita
Allele Symbol: Ins2Akita
| Allele Name | Akita |
|---|---|
| Allele Type | Spontaneous |
| Allele Synonym(s) | Akita; AkitaIns2; Ins2C96Y; Ins2Mody; Mody; Mody4 |
| Gene Symbol and Name | Ins2, insulin II |
| Gene Synonym(s) | AA986540; CP-II; IDDM; IDDM1; IDDM2; ILPR; IRDN; Ins-2; Ins-2; InsII; MODY10; Mody; Mody; Mody4; Mody4; expressed sequence AA986540; maturity onset diabetes of the young; maturity onset diabetes of the young 4 |
| Strain of Origin | C57BL/6NSlc |
| Chromosome | 7 |
| Molecular Note | In the mutant allele a transition from G to A at nucleotide 1907 disrupted an Fnu4HI site in exon 3. This mutation changed the seventh amino acid in the A chain of mature insulin, Cys96 (TGC), to Tyr (TAC). The authors predict that the transition would disrupt a disulfide bond between the A and the B chains and would likely induce a major conformational change in insulin 2 molecules. RT-PCR studies suggest that both normal and mutant Ins2 alleles are transcribed similarly in pancreatic islets of heterozygous mice, although immunofluorescence and immunoblot analyses of heterozygous islets detected reduced levels of insulin and proinsulin. |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Apoptosis Research
- Cancer Research
- Growth Factors/Receptors/Cytokines
- Osteoporosis
- Growth Factors/Receptors/Cytokines
- Diabetes and Obesity Research
- Hyperglycemia
- Hypoinsulinemia
- Impaired Insulin Processing
- Insulin Receptors and Growth Factors
- Type 1 Diabetes (IDDM)
- MODY, mature onset diabetes of the young
- Immunology, Inflammation and Autoimmunity Research
- Autoimmunity
- Type 1 Diabetes
- Inflammation
- Autoimmunity
- Internal/Organ Research
- Kidney Defects
- Skeleton
- Bone
Genotype: Bdkrb2tm1Jfh related
- Cardiovascular Research
- Hypertension
- diet-induced
- Hypertension
- Immunology, Inflammation and Autoimmunity Research
- Inflammation
Genotype: Ins2Akita related
- Cell Biology Research
- Protein Processing
- Diabetes and Obesity Research
- Hyperglycemia
- Hypoinsulinemia
- Impaired Insulin Processing
- Insulin Receptors and Growth Factors
- Islet Transplantation Studies
- Type 1 Diabetes (IDDM)
- MODY, mature onset diabetes of the young
- Endocrine Deficiency Research
- Pancreas Defects
Mammalian Phenotype Terms by Genotype
Genotype: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh Ins2Akita/Ins2+
B6.Cg-Ins2Akita Bdkrb2tm1Jfh
mortality/aging
- premature death
- mice have much shorter lifespan than wild-type; 909 days (wt) vs 246 days (mutant) (MGI Ref ID J:108948)
cellular phenotype
- abnormal mitochondrial chromosome morphology
- mutants display increased mitochondrial DNA damage compared to single mutants or wild-type mice at 12 months of age (MGI Ref ID J:108948)
- abnormal spermatogonia morphology
- in double mutant males, severe loss of spermatogonia is observed and atrophy of spermatic cords is prevalent at 12 months of age (MGI Ref ID J:108948)
endocrine/exocrine gland phenotype
- abnormal Leydig cell morphology
- double mutant males display numerous pigmented vacuoles in Leydig cells in the testes at 12 months of age (MGI Ref ID J:108948)
- abnormal seminiferous tubule morphology
- double mutants have an increased frequency of apoptotic cells in the seminiferous tubules at 12 months of age (MGI Ref ID J:108948)
reproductive system phenotype
- abnormal Leydig cell morphology
- double mutant males display numerous pigmented vacuoles in Leydig cells in the testes at 12 months of age (MGI Ref ID J:108948)
- abnormal seminiferous tubule morphology
- double mutants have an increased frequency of apoptotic cells in the seminiferous tubules at 12 months of age (MGI Ref ID J:108948)
- abnormal spermatogonia morphology
- in double mutant males, severe loss of spermatogonia is observed and atrophy of spermatic cords is prevalent at 12 months of age (MGI Ref ID J:108948)
digestive/alimentary phenotype
- abnormal intestinal epithelium morphology
- intestinal villi in mutants have a greater frequency of apoptotic cells (MGI Ref ID J:108948)
adipose tissue phenotype
- decreased subcutaneous adipose tissue amount
- mutants have almost no subcutaneous fat (MGI Ref ID J:108948)
skeleton phenotype
- decreased bone mineral density
- double mutants have significantly reduced bone density compared to wild-type or single mutant mice (MGI Ref ID J:108948)
- kyphosis
- double mutants exhibit marked kyphosis (MGI Ref ID J:108948)
integument phenotype
- alopecia
- most mutants show significant alopecia by 12 months of age (MGI Ref ID J:108948)
- decreased subcutaneous adipose tissue amount
- mutants have almost no subcutaneous fat (MGI Ref ID J:108948)
References
- Kakoki M; Kizer CM; Yi X; Takahashi N; Kim HS; Bagnell CR; Edgell CJ; Maeda N; Jennette JC; Smithies O. 2006. Senescence-associated phenotypes in Akita diabetic mice are enhanced by absence of bradykinin B2 receptors. J Clin Invest 116(5):1302-9. PubMed: 16604193MGI: J:108948
- Kakoki M; McGarrah RW; Kim HS; Smithies O. 2007. Bradykinin B1 and B2 receptors both have protective roles in renal ischemia/reperfusion injury. Proc Natl Acad Sci U S A 104(18):7576-81. PubMed: 17452647MGI: J:121339
- Kakoki M; Takahashi N; Jennette JC; Smithies O. 2004. Diabetic nephropathy is markedly enhanced in mice lacking the bradykinin B2 receptor. Proc Natl Acad Sci U S A 101(36):13302-5. PubMed: 15326315MGI: J:92403
Additional - Bdkrb2tm1Jfh related
- Abadir PM; Carey RM; Siragy HM. 2003. Angiotensin AT2 receptors directly stimulate renal nitric oxide in bradykinin B2-receptor-null mice. Hypertension 42(4):600-4. PubMed: 12953015MGI: J:103114
- Adolfo Arganaraz G; Regina Perosa S; Cristina Lencioni E; Bader M; Abrao Cavalheiro E; da Graca Naffah-Mazzacoratti M; Bosco Pesquero J; Antonio Silva J Jr. 2004. Role of kinin B1 and B2 receptors in the development of pilocarpine model of epilepsy. Brain Res 1013(1):30-9. PubMed: 15196965MGI: J:90943
- Alfie ME; Alim S; Mehta D; Shesely EG; Carretero OA. 1999. An enhanced effect of arginine vasopressin in bradykinin B2 receptor null mutant mice. Hypertension 33(6):1436-40. PubMed: 10373229MGI: J:56192
- Alfie ME; Yang XP; Hess F; Carretero OA. 1996. Salt-sensitive hypertension in bradykinin B2 receptor knockout mice. Biochem Biophys Res Commun 224(3):625-30. PubMed: 8713099MGI: J:34497
- Aliberti J; Viola JP; Vieira-de-Abreu A; Bozza PT; Sher A; Scharfstein J. 2003. Cutting edge: Bradykinin induces IL-12 production by dendritic cells: a danger signal that drives Th1 polarization. J Immunol 170(11):5349-53. PubMed: 12759407MGI: J:83453
- Barros CC; Haro A; Russo FJ; Schadock I; Almeida SS; Reis FC; Moraes MR; Haidar A; Hirata AE; Mori M; Bacurau RF; Wurtele M; Bader M; Pesquero JB; Araujo RC. 2012. Bradykinin inhibits hepatic gluconeogenesis in obese mice. Lab Invest 92(10):1419-27. PubMed: 22868909MGI: J:188609
- Bergaya S; Meneton P; Bloch-Faure M; Mathieu E; Alhenc-Gelas F; Levy BI; Boulanger CM. 2001. Decreased flow-dependent dilation in carotid arteries of tissue kallikrein-knockout mice. Circ Res 88(6):593-9. PubMed: 11282893MGI: J:115590
- Bernstein KE; Xiao HD; Frenzel K; Li P; Shen XZ; Adams JW; Fuchs S. 2005. Six truisms concerning ACE and the renin-angiotensin system educed from the genetic analysis of mice. Circ Res 96(11):1135-44. PubMed: 15947253MGI: J:109628
- Bhagat TD; Zhou L; Sokol L; Kessel R; Caceres G; Gundabolu K; Tamari R; Gordon S; Mantzaris I; Jodlowski T; Yu Y; Jing X; Polineni R; Bhatia K; Pellagatti A; Boultwood J; Kambhampati S; Steidl U; Stein C; Ju W; Liu G; Kenny P; List A; Bitzer M; Verma A. 2013. miR-21 mediates hematopoietic suppression in MDS by activating TGF-beta signaling. Blood 121(15):2875-81. PubMed: 23390194MGI: J:196470
- Blaes N; Pecher C; Mehrenberger M; Cellier E; Praddaude F; Chevalier J; Tack I; Couture R; Girolami JP. 2012. Bradykinin inhibits high glucose- and growth factor-induced collagen synthesis in mesangial cells through the B2-kinin receptor. Am J Physiol Renal Physiol 303(2):F293-303. PubMed: 22573379MGI: J:187019
- Borkowski JA; Ransom RW; Seabrook GR; Trumbauer M; Chen H; Hill RG; Strader CD; Hess JF. 1995. Targeted disruption of a B2 bradykinin receptor gene in mice eliminates bradykinin action in smooth muscle and neurons. J Biol Chem 270(23):13706-10. PubMed: 7775424MGI: J:25953
- Brochu I; Labonte J; Bkaily G; D'Orleans-Juste P. 2002. Role of endothelin receptors in the hypertensive state of kinin B(2) knockout mice subjected to a high-salt diet. Clin Sci (Lond) 103 Suppl 48:380S-384S. PubMed: 12193127MGI: J:103135
- Cervenka L; Harrison-Bernard LM; Dipp S; Primrose G; Imig JD; El-Dahr SS. 1999. Early onset salt-sensitive hypertension in bradykinin B(2) receptor null mice. Hypertension 34(2):176-80. PubMed: 10454437MGI: J:88466
- Cervenka L; Vaneckova I; Maly J; Horacek V; El-Dahr SS. 2003. Genetic inactivation of the B2 receptor in mice worsens two-kidney, one-clip hypertension: role of NO and the AT2 receptor. J Hypertens 21(8):1531-8. PubMed: 12872048MGI: J:106003
- Diehl SA; McElvany B; Noubade R; Seeberger N; Harding B; Spach K; Teuscher C. 2014. G proteins Galphai1/3 are critical targets for Bordetella pertussis toxin-induced vasoactive amine sensitization. Infect Immun 82(2):773-82. PubMed: 24478091MGI: J:209809
- Duka I; Kintsurashvili E; Gavras I; Johns C; Bresnahan M; Gavras H. 2001. Vasoactive potential of the b(1) bradykinin receptor in normotension and hypertension. Circ Res 88(3):275-81. PubMed: 11179194MGI: J:115601
- Duka I; Shenouda S; Johns C; Kintsurashvili E; Gavras I; Gavras H. 2001. Role of the B(2) receptor of bradykinin in insulin sensitivity. Hypertension 38(6):1355-60. PubMed: 11751717MGI: J:103241
- Dutra RC; Bento AF; Leite DF; Manjavachi MN; Marcon R; Bicca MA; Pesquero JB; Calixto JB. 2013. The role of kinin B1 and B2 receptors in the persistent pain induced by experimental autoimmune encephalomyelitis (EAE) in mice: evidence for the involvement of astrocytes. Neurobiol Dis 54:82-93. PubMed: 23454198MGI: J:197950
- Dutra RC; Leite DF; Bento AF; Manjavachi MN; Patricio ES; Figueiredo CP; Pesquero JB; Calixto JB. 2011. The role of kinin receptors in preventing neuroinflammation and its clinical severity during experimental autoimmune encephalomyelitis in mice. PLoS One 6(11):e27875. PubMed: 22132157MGI: J:201039
- El-Dahr SS; Aboudehen K; Dipp S. 2008. Bradykinin B2 receptor null mice harboring a Ser23-to-Ala substitution in the p53 gene are protected from renal dysgenesis. Am J Physiol Renal Physiol 295(5):F1404-13. PubMed: 18753293MGI: J:140998
- El-Dahr SS; Harrison-Bernard LM; Dipp S; Yosipiv IV; Meleg-Smith S. 2000. Bradykinin B2 null mice are prone to renal dysplasia: gene-environment interactions in kidney development Physiol Genomics 3(3):121-31. PubMed: 11015607MGI: J:65386
- Emanueli C; Fink E; Milia AF; Salis MB; Conti M; Demontis MP; Madeddu P. 1998. Enhanced blood pressure sensitivity to deoxycorticosterone in mice with disruption of bradykinin B2 receptor gene. Hypertension 31(6):1278-83. PubMed: 9622142MGI: J:48384
- Emanueli C; Maestri R; Corradi D; Marchione R; Minasi A; Tozzi MG; Salis MB; Straino S; Capogrossi MC; Olivetti G; Madeddu P. 1999. Dilated and failing cardiomyopathy in bradykinin B(2) receptor knockout mice [see comments] Circulation 100(23):2359-65. PubMed: 10587341MGI: J:59835
- Fan H; Harrell JR; Dipp S; Saifudeen Z; El-Dahr SS. 2005. A novel pathological role of p53 in kidney development revealed by gene-environment interactions. Am J Physiol Renal Physiol 288(1):F98-107. PubMed: 15383401MGI: J:104678
- Fan H; Stefkova J; El-Dahr SS. 2006. Susceptibility to metanephric apoptosis in bradykinin B2 receptor null mice via the p53-Bax pathway. Am J Physiol Renal Physiol 291(3):F670-82. PubMed: 16571598MGI: J:111678
- Fang C; Stavrou E; Schmaier AA; Grobe N; Morris M; Chen A; Nieman MT; Adams GN; LaRusch G; Zhou Y; Bilodeau ML; Mahdi F; Warnock M; Schmaier AH. 2013. Angiotensin 1-7 and Mas decrease thrombosis in Bdkrb2-/- mice by increasing NO and prostacyclin to reduce platelet spreading and glycoprotein VI activation. Blood 121(15):3023-32. PubMed: 23386129MGI: J:196472
- Ferreira J; Campos MM; Pesquero JB; Araujo RC; Bader M; Calixto JB. 2001. Evidence for the participation of kinins in Freund's adjuvant-induced inflammatory and nociceptive responses in kinin B1 and B2 receptor knockout mice. Neuropharmacology 41(8):1006-12. PubMed: 11747905MGI: J:179423
- Gobel K; Pankratz S; Asaridou CM; Herrmann AM; Bittner S; Merker M; Ruck T; Glumm S; Langhauser F; Kraft P; Krug TF; Breuer J; Herold M; Gross CC; Beckmann D; Korb-Pap A; Schuhmann MK; Kuerten S; Mitroulis I; Ruppert C; Nolte MW; Panousis C; Klotz L; Kehrel B; Korn T; Langer HF; Pap T; Nieswandt B; Wiendl H; Chavakis T; Kleinschnitz C; Meuth SG. 2016. Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells. Nat Commun 7:11626. PubMed: 27188843MGI: J:239929
- Han ED; MacFarlane RC; Mulligan AN; Scafidi J; Davis AE 3rd. 2002. Increased vascular permeability in C1 inhibitor-deficient mice mediated by the bradykinin type 2 receptor. J Clin Invest 109(8):1057-63. PubMed: 11956243MGI: J:76090
- Harrison-Bernard LM; Dipp S; El-Dahr SS. 2003. Renal and blood pressure phenotype in 18-mo-old bradykinin B2R(-/-)CRD mice. Am J Physiol Regul Integr Comp Physiol 285(4):R782-90. PubMed: 12805091MGI: J:84494
- Hess JF; Chen RZ; Hey P; Breese R; Chang RS; Chen TB; Bock MG; Vogt T; Pettibone DJ. 2006. Generation and characterization of a humanized bradykinin B1 receptor mouse. Biol Chem 387(2):195-201. PubMed: 16497152MGI: J:135789
- Hillmeister P; Gatzke N; Dulsner A; Bader M; Schadock I; Hoefer I; Hamann I; Infante-Duarte C; Jung G; Troidl K; Urban D; Stawowy P; Frentsch M; Li M; Nagorka S; Wang H; Shi Y; le Noble F; Buschmann I. 2011. Arteriogenesis is modulated by bradykinin receptor signaling. Circ Res 109(5):524-33. PubMed: 21719759MGI: J:186598
- Isbell DC; Voros S; Yang Z; DiMaria JM; Berr SS; French BA; Epstein FH; Bishop SP; Wang H; Roy RJ; Kemp BA; Matsubara H; Carey RM; Kramer CM. 2007. Interaction between bradykinin subtype 2 and angiotensin II type 2 receptors during post-MI left ventricular remodeling. Am J Physiol Heart Circ Physiol 293(6):H3372-8. PubMed: 17933966MGI: J:132208
- Jaffa MA; Kobeissy F; Al Hariri M; Chalhoub H; Eid A; Ziyadeh FN; Jaffa AA. 2012. Global renal gene expression profiling analysis in B2-kinin receptor null mice: impact of diabetes. PLoS One 7(9):e44714. PubMed: 23028588MGI: J:191871
- Kahn R; Hellmark T; Leeb-Lundberg LM; Akbari N; Todiras M; Olofsson T; Wieslander J; Christensson A; Westman K; Bader M; Muller-Esterl W; Karpman D. 2009. Neutrophil-derived proteinase 3 induces kallikrein-independent release of a novel vasoactive kinin. J Immunol 182(12):7906-15. PubMed: 19494315MGI: J:149285
- Kakoki M; Sullivan KA; Backus C; Hayes JM; Oh SS; Hua K; Gasim AM; Tomita H; Grant R; Nossov SB; Kim HS; Jennette JC; Feldman EL; Smithies O. 2010. Lack of both bradykinin B1 and B2 receptors enhances nephropathy, neuropathy, and bone mineral loss in Akita diabetic mice. Proc Natl Acad Sci U S A 107(22):10190-5. PubMed: 20479236MGI: J:161075
- Krankel N; Kuschnerus K; Muller M; Speer T; Mocharla P; Madeddu P; Bader M; Luscher TF; Landmesser U. 2013. Novel insights into the critical role of bradykinin and the kinin B2 receptor for vascular recruitment of circulating endothelial repair-promoting mononuclear cell subsets: alterations in patients with coronary disease. Circulation 127(5):594-603. PubMed: 23275384MGI: J:210277
- Lu F; Chauhan AK; Fernandes SM; Walsh MT; Wagner DD; Davis AE 3rd. 2008. The effect of C1 inhibitor on intestinal ischemia and reperfusion injury. Am J Physiol Gastrointest Liver Physiol 295(5):G1042-9. PubMed: 18787060MGI: J:142529
- Madeddu P; Emanueli C; Gaspa L; Salis B; Milia AF; Chao L; Chao J. 1999. Role of the bradykinin B2 receptor in the maturation of blood pressure phenotype: lesson from transgenic and knockout mice Immunopharmacology 44(1-2):9-13. PubMed: 10604518MGI: J:59794
- Madeddu P; Emanueli C; Maestri R; Salis MB; Minasi A; Capogrossi MC; Olivetti G. 2000. Angiotensin II type 1 receptor blockade prevents cardiac remodeling in bradykinin B(2) receptor knockout mice Hypertension 35(1 Pt 2):391-6. PubMed: 10642330MGI: J:60047
- Madeddu P; Salis MB; Emanueli C. 1999. Altered baroreflex control of heart rate in bradykinin B2-receptor knockout mice Immunopharmacology 45(1-3):21-7. PubMed: 10614985MGI: J:59776
- Madeddu P; Varoni MV; Palomba D; Emanueli C; Demontis MP; Glorioso N; Dessi-Fulgheri P; Sarzani R; Anania V. 1997. Cardiovascular phenotype of a mouse strain with disruption of bradykinin B2-receptor gene. Circulation 96(10):3570-8. PubMed: 9396457MGI: J:112265
- Maestri R; Milia AF; Salis MB; Graiani G; Lagrasta C; Monica M; Corradi D; Emanueli C; Madeddu P. 2003. Cardiac hypertrophy and microvascular deficit in kinin B2 receptor knockout mice. Hypertension 41(5):1151-5. PubMed: 12654715MGI: J:103026
- Maul B; Krause W; Pankow K; Becker M; Gembardt F; Alenina N; Walther T; Bader M; Siems WE. 2005. Central angiotensin II controls alcohol consumption via its AT1 receptor. FASEB J 19(11):1474-81. PubMed: 16126915MGI: J:101196
- Milia AF; Gross V; Plehm R; De Silva JA Jr; Bader M; Luft FC. 2001. Normal blood pressure and renal function in mice lacking the bradykinin B(2) receptor. Hypertension 37(6):1473-9. PubMed: 11408397MGI: J:103234
- Monteiro AC; Schmitz V; Svensjo E; Gazzinelli RT; Almeida IC; Todorov A; de Arruda LB; Torrecilhas AC; Pesquero JB; Morrot A; Bouskela E; Bonomo A; Lima AP; Muller-Esterl W; Scharfstein J. 2006. Cooperative activation of TLR2 and bradykinin B2 receptor is required for induction of type 1 immunity in a mouse model of subcutaneous infection by Trypanosoma cruzi. J Immunol 177(9):6325-35. PubMed: 17056563MGI: J:140513
- Picard N; Eladari D; El Moghrabi S; Planes C; Bourgeois S; Houillier P; Wang Q; Burnier M; Deschenes G; Knepper MA; Meneton P; Chambrey R. 2008. Defective ENaC processing and function in tissue kallikrein-deficient mice. J Biol Chem 283(8):4602-11. PubMed: 18086683MGI: J:132178
- Prediger RD; Medeiros R; Pandolfo P; Duarte FS; Passos GF; Pesquero JB; Campos MM; Calixto JB; Takahashi RN. 2008. Genetic deletion or antagonism of kinin B(1) and B(2) receptors improves cognitive deficits in a mouse model of Alzheimer's disease. Neuroscience 151(3):631-43. PubMed: 18191900MGI: J:135258
- Rhaleb NE; Peng H; Alfie ME; Shesely EG; Carretero OA. 1999. Effect of ACE inhibitor on DOCA-salt- and aortic coarctation-induced hypertension in mice: do kinin B2 receptors play a role? Hypertension 33(1 Pt 2):329-34. PubMed: 9931125MGI: J:53680
- Rodi D; Buzzi A; Barbieri M; Zucchini S; Verlengia G; Binaschi A; Regoli D; Boschi A; Ongali B; Couture R; Simonato M. 2013. Bradykinin B receptors increase hippocampal excitability and susceptibility to seizures in mice. Neuroscience 248C:392-402. PubMed: 23811399MGI: J:207053
- Rodrigues ES; Martin RP; Felipe SA; Bader M; Oliveira SM; Shimuta SI. 2009. Cross talk between kinin and angiotensin II receptors in mouse abdominal aorta. Biol Chem 390(9):907-13. PubMed: 19453270MGI: J:164962
- Rupniak NM; Boyce S; Webb JK; Williams AR; Carlson EJ; Hill RG ; Borkowski JA ; Hess JF. 1997. Effects of the bradykinin B1 receptor antagonist des-Arg9[Leu8]bradykinin and genetic disruption of the B2 receptor on nociception in rats and mice. Pain 71(1):89-97. PubMed: 9200178MGI: J:41328
- Sanchez de Miguel L; Neysari S; Jakob S; Petrimpol M; Butz N; Banfi A; Zaugg CE; Humar R; Battegay EJ. 2008. B2-kinin receptor plays a key role in B1-, angiotensin converting enzyme inhibitor-, and vascular endothelial growth factor-stimulated in vitro angiogenesis in the hypoxic mouse heart. Cardiovasc Res 80(1):106-13. PubMed: 18566101MGI: J:161893
- Schanstra JP; Bachvarova M; Neau E; Bascands JL; Bachvarov D. 2007. Gene expression profiling in the remnant kidney model of wild type and kinin B1 and B2 receptor knockout mice. Kidney Int 72(4):442-54. PubMed: 17579666MGI: J:152886
- Schanstra JP; Duchene J; Praddaude F; Bruneval P; Tack I; Chevalier J; Girolami JP; Bascands JL. 2003. Decreased renal NO excretion and reduced glomerular tuft area in mice lacking the bradykinin B2 receptor. Am J Physiol Heart Circ Physiol 284(6):H1904-8. PubMed: 12560214MGI: J:83895
- Schanstra JP; Neau E; Drogoz P; Arevalo Gomez MA; Lopez Novoa JM; Calise D; Pecher C; Bader M; Girolami JP; Bascands JL. 2002. In vivo bradykinin B2 receptor activation reduces renal fibrosis. J Clin Invest 110(3):371-9. PubMed: 12163456MGI: J:78354
- Shariat-Madar Z; Mahdi F; Warnock M; Homeister JW; Srikanth S; Krijanovski Y; Murphey LJ; Jaffa AA; Schmaier AH. 2006. Bradykinin B2 receptor knockout mice are protected from thrombosis by increased nitric oxide and prostacyclin. Blood 108(1):192-9. PubMed: 16514058MGI: J:135575
- Silvestre JS; Bergaya S; Tamarat R; Duriez M; Boulanger CM; Levy BI. 2001. Proangiogenic effect of angiotensin-converting enzyme inhibition is mediated by the bradykinin B(2) receptor pathway. Circ Res 89(8):678-83. PubMed: 11597990MGI: J:115630
- Song JJ; Hwang I; Cho KH; Garcia MA; Kim AJ; Wang TH; Lindstrom TM; Lee AT; Nishimura T; Zhao L; Morser J; Nesheim M; Goodman SB; Lee DM; Bridges SL Jr; Gregersen PK; Leung LL; Robinson WH. 2011. Plasma carboxypeptidase B downregulates inflammatory responses in autoimmune arthritis. J Clin Invest 121(9):3517-27. PubMed: 21804193MGI: J:178261
- Strecker T; Messlinger K; Weyand M; Reeh PW. 2005. Role of different proton-sensitive channels in releasing calcitonin gene-related peptide from isolated hearts of mutant mice. Cardiovasc Res 65(2):405-10. PubMed: 15639479MGI: J:101967
- Tan Y; Keum JS; Wang B; McHenry MB; Lipsitz SR; Jaffa AA. 2007. Targeted deletion of B2-kinin receptors protects against the development of diabetic nephropathy. Am J Physiol Renal Physiol 293(4):F1026-35. PubMed: 17596525MGI: J:142936
- Trabold F; Pons S; Hagege AA; Bloch-Faure M; Alhenc-Gelas F; Giudicelli JF; Richer-Giudicelli C; Meneton P. 2002. Cardiovascular phenotypes of kinin B2 receptor- and tissue kallikrein-deficient mice. Hypertension 40(1):90-5. PubMed: 12105144MGI: J:103162
- Trevisani M; Schmidlin F; Tognetto M; Nijkamp FP; Gies JP; Frossard N; Amadesi S; Folkerts G; Geppetti P. 1999. Evidence for in vitro expression of B1 receptor in the mouse trachea and urinary bladder. Br J Pharmacol 126(6):1293-300. PubMed: 10217521MGI: J:54390
- Vashistha H; Singhal PC; Malhotra A; Husain M; Mathieson P; Saleem MA; Kuriakose C; Seshan S; Wilk A; Delvalle L; Peruzzi F; Giorgio M; Pelicci PG; Smithies O; Kim HS; Kakoki M; Reiss K; Meggs LG. 2012. Null mutations at the p66 and bradykinin 2 receptor loci induce divergent phenotypes in the diabetic kidney. Am J Physiol Renal Physiol 303(12):F1629-40. PubMed: 23019230MGI: J:190320
- Wang H; Kohno T; Amaya F; Brenner GJ; Ito N; Allchorne A; Ji RR; Woolf CJ. 2005. Bradykinin produces pain hypersensitivity by potentiating spinal cord glutamatergic synaptic transmission. J Neurosci 25(35):7986-92. PubMed: 16135755MGI: J:100473
- Xi L; Das A; Zhao ZQ; Merino VF; Bader M; Kukreja RC. 2008. Loss of myocardial ischemic postconditioning in adenosine A1 and bradykinin B2 receptors gene knockout mice. Circulation 118(14 Suppl):S32-7. PubMed: 18824766MGI: J:158042
- Xia CF; Smith RS Jr; Shen B; Yang ZR; Borlongan CV; Chao L; Chao J. 2006. Postischemic brain injury is exacerbated in mice lacking the kinin B2 receptor. Hypertension 47(4):752-61. PubMed: 16534002MGI: J:135763
- Xiao HD; Fuchs S; Cole JM; Disher KM; Sutliff RL; Bernstein KE. 2003. Role of bradykinin in angiotensin-converting enzyme knockout mice. Am J Physiol Heart Circ Physiol 284(6):H1969-77. PubMed: 12637363MGI: J:83894
- Yang XP; Liu YH; Mehta D; Cavasin MA; Shesely E; Xu J; Liu F; Carretero OA. 2001. Diminished cardioprotective response to inhibition of angiotensin-converting enzyme and angiotensin II type 1 receptor in B(2) kinin receptor gene knockout mice. Circ Res 88(10):1072-9. PubMed: 11375278MGI: J:111458
- Yosipiv IV; Dipp S; El-Dahr SS. 2001. Targeted disruption of the bradykinin B(2) receptor gene in mice alters the ontogeny of the renin-angiotensin system. Am J Physiol Renal Physiol 281(5):F795-801. PubMed: 11592936MGI: J:72552
- Zaika O; Zhang J; Shapiro MS. 2011. Functional role of M-type (KCNQ) K(+) channels in adrenergic control of cardiomyocyte contraction rate by sympathetic neurons. J Physiol 589(Pt 10):2559-68. PubMed: 21486761MGI: J:185252
Additional - Ins2Akita related
- Abdo S; Shi Y; Otoukesh A; Ghosh A; Lo CS; Chenier I; Filep JG; Ingelfinger JR; Zhang SL; Chan JS. 2014. Catalase overexpression prevents nuclear factor erythroid 2-related factor 2 stimulation of renal angiotensinogen gene expression, hypertension, and kidney injury in diabetic mice. Diabetes 63(10):3483-96. PubMed: 24812425MGI: J:229839
- Abudukadier A; Fujita Y; Obara A; Ohashi A; Fukushima T; Sato Y; Ogura M; Nakamura Y; Fujimoto S; Hosokawa M; Hasegawa H; Inagaki N. 2013. Tetrahydrobiopterin has a glucose-lowering effect by suppressing hepatic gluconeogenesis in an endothelial nitric oxide synthase-dependent manner in diabetic mice. Diabetes 62(9):3033-43. PubMed: 23649519MGI: J:208962
- Aghdam SY; Gurel Z; Ghaffarieh A; Sorenson CM; Sheibani N. 2013. High glucose and diabetes modulate cellular proteasome function: Implications in the pathogenesis of diabetes complications. Biochem Biophys Res Commun 432(2):339-44. PubMed: 23391566MGI: J:198848
- Akimov NP; Renteria RC. 2012. Spatial frequency threshold and contrast sensitivity of an optomotor behavior are impaired in the Ins2Akita mouse model of diabetes. Behav Brain Res 226(2):601-5. PubMed: 21963766MGI: J:180197
- Asakawa A; Toyoshima M; Inoue K; Koizumi A. 2007. Ins2Akita mice exhibit hyperphagia and anxiety behavior via the melanocortin system. Int J Mol Med 19(4):649-52. PubMed: 17334640MGI: J:125256
- Awad AS; Kinsey GR; Khutsishvili K; Gao T; Bolton WK; Okusa MD. 2011. Monocyte/macrophage chemokine receptor CCR2 mediates diabetic renal injury. Am J Physiol Renal Physiol 301(6):F1358-66. PubMed: 21880831MGI: J:180042
- Bachar-Wikstrom E; Wikstrom JD; Ariav Y; Tirosh B; Kaiser N; Cerasi E; Leibowitz G. 2013. Stimulation of autophagy improves endoplasmic reticulum stress-induced diabetes. Diabetes 62(4):1227-37. PubMed: 23274896MGI: J:208584
- Barber AJ; Antonetti DA; Kern TS; Reiter CE; Soans RS; Krady JK; Levison SW; Gardner TW; Bronson SK. 2005. The Ins2Akita mouse as a model of early retinal complications in diabetes. Invest Ophthalmol Vis Sci 46(6):2210-8. PubMed: 15914643MGI: J:99412
- Basu R; Lee J; Wang Z; Patel VB; Fan D; Das SK; Liu GC; John R; Scholey JW; Oudit GY; Kassiri Z. 2012. Loss of TIMP3 selectively exacerbates diabetic nephropathy. Am J Physiol Renal Physiol 303(9):F1341-52. PubMed: 22896043MGI: J:189948
- Basu R; Oudit GY; Wang X; Zhang L; Ussher JR; Lopaschuk GD; Kassiri Z. 2009. Type 1 diabetic cardiomyopathy in the Akita (Ins2WT/C96Y) mouse model is characterized by lipotoxicity and diastolic dysfunction with preserved systolic function. Am J Physiol Heart Circ Physiol 297(6):H2096-108. PubMed: 19801494MGI: J:158228
- Blum B; Roose AN; Barrandon O; Maehr R; Arvanites AC; Davidow LS; Davis JC; Peterson QP; Rubin LL; Melton DA. 2014. Reversal of beta cell de-differentiation by a small molecule inhibitor of the TGFbeta pathway. Elife 3:e02809. PubMed: 25233132MGI: J:218054
- Bostrom KI; Jumabay M; Matveyenko A; Nicholas SB; Yao Y. 2011. Activation of vascular bone morphogenetic protein signaling in diabetes mellitus. Circ Res 108(4):446-57. PubMed: 21193740MGI: J:183498
- Bugger H; Boudina S; Hu XX; Tuinei J; Zaha VG; Theobald HA; Yun UJ; McQueen AP; Wayment B; Litwin SE; Abel ED. 2008. Type 1 diabetic akita mouse hearts are insulin sensitive but manifest structurally abnormal mitochondria that remain coupled despite increased uncoupling protein 3. Diabetes 57(11):2924-32. PubMed: 18678617MGI: J:142159
- Bugger H; Chen D; Riehle C; Soto J; Theobald HA; Hu XX; Ganesan B; Weimer BC; Abel ED. 2009. Tissue-specific remodeling of the mitochondrial proteome in type 1 diabetic akita mice. Diabetes 58(9):1986-97. PubMed: 19542201MGI: J:154406
- Chacko BK; Reily C; Srivastava A; Johnson MS; Ye Y; Ulasova E; Agarwal A; Zinn KR; Murphy MP; Kalyanaraman B; Darley-Usmar V. 2010. Prevention of diabetic nephropathy in Ins2(+/)(AkitaJ) mice by the mitochondria-targeted therapy MitoQ. Biochem J 432(1):9-19. PubMed: 20825366MGI: J:166866
- Chang AS; Dale AN; Moley KH. 2005. Maternal diabetes adversely affects preovulatory oocyte maturation, development, and granulosa cell apoptosis. Endocrinology 146(5):2445-53. PubMed: 15718275MGI: J:129826
- Chang JH; Paik SY; Mao L; Eisner W; Flannery PJ; Wang L; Tang Y; Mattocks N; Hadjadj S; Goujon JM; Ruiz P; Gurley SB; Spurney RF. 2012. Diabetic kidney disease in FVB/NJ Akita mice: temporal pattern of kidney injury and urinary nephrin excretion. PLoS One 7(4):e33942. PubMed: 22496773MGI: J:187110
- Chavali V; Tyagi SC; Mishra PK. 2012. MicroRNA-133a regulates DNA methylation in diabetic cardiomyocytes. Biochem Biophys Res Commun 425(3):668-72. PubMed: 22842467MGI: J:188036
- Chen H; Li J; Jiao L; Petersen RB; Li J; Peng A; Zheng L; Huang K. 2014. Apelin inhibits the development of diabetic nephropathy by regulating histone acetylation in Akita mouse. J Physiol 592(Pt 3):505-21. PubMed: 24247978MGI: J:217958
- Chen Q; Takahashi Y; Oka K; Ma JX. 2016. Functional Differences of Very-Low-Density Lipoprotein Receptor Splice Variants in Regulating Wnt Signaling. Mol Cell Biol 36(20):2645-54. PubMed: 27528615MGI: J:236304
- Cheng L; Han X; Shi Y. 2009. A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice. Am J Physiol Endocrinol Metab 297(6):E1276-82. PubMed: 19773578MGI: J:159566
- Choeiri C; Hewitt K; Durkin J; Simard CJ; Renaud JM; Messier C. 2005. Longitudinal evaluation of memory performance and peripheral neuropathy in the Ins2(C96Y) Akita mice. Behav Brain Res 157(1):31-8. PubMed: 15617768MGI: J:95284
- Denhez B; Lizotte F; Guimond MO; Jones N; Takano T; Geraldes P. 2015. Increased SHP-1 protein expression by high glucose levels reduces nephrin phosphorylation in podocytes. J Biol Chem 290(1):350-8. PubMed: 25404734MGI: J:218390
- Dennis MD; Schrufer TL; Bronson SK; Kimball SR; Jefferson LS. 2011. Hyperglycemia-Induced O-GlcNAcylation and Truncation of 4E-BP1 Protein in Liver of a Mouse Model of Type 1 Diabetes. J Biol Chem 286(39):34286-97. PubMed: 21840999MGI: J:176719
- Dokun AO; Chen L; Lanjewar SS; Lye RJ; Annex BH. 2014. Glycaemic control improves perfusion recovery and VEGFR2 protein expression in diabetic mice following experimental PAD. Cardiovasc Res 101(3):364-72. PubMed: 24385342MGI: J:220054
- Drapeau N; Lizotte F; Denhez B; Guay A; Kennedy CR; Geraldes P. 2013. Expression of SHP-1 induced by hyperglycemia prevents insulin actions in podocytes. Am J Physiol Endocrinol Metab 304(11):E1188-98. PubMed: 23531619MGI: J:198982
- Dugan LL; You YH; Ali SS; Diamond-Stanic M; Miyamoto S; DeCleves AE; Andreyev A; Quach T; Ly S; Shekhtman G; Nguyen W; Chepetan A; Le TP; Wang L; Xu M; Paik KP; Fogo A; Viollet B; Murphy A; Brosius F; Naviaux RK; Sharma K. 2013. AMPK dysregulation promotes diabetes-related reduction of superoxide and mitochondrial function. J Clin Invest 123(11):4888-99. PubMed: 24135141MGI: J:204683
- Fang F; Bae EH; Hu A; Liu GC; Zhou X; Williams V; Maksimowski N; Lu C; Konvalinka A; John R; Scholey JW. 2015. Deletion of the gene for adiponectin accelerates diabetic nephropathy in the Ins2 (+/C96Y) mouse. Diabetologia 58(7):1668-78. PubMed: 25957229MGI: J:224619
- Fang RC; Kryger ZB; Buck DW 2nd; De la Garza M; Galiano RD; Mustoe TA. 2010. Limitations of the db/db mouse in translational wound healing research: Is the NONcNZO10 polygenic mouse model superior? Wound Repair Regen 18(6):605-13. PubMed: 20955341MGI: J:165705
- Faulhaber-Walter R; Chen L; Oppermann M; Kim SM; Huang Y; Hiramatsu N; Mizel D; Kajiyama H; Zerfas P; Briggs JP; Kopp JB; Schnermann J. 2008. Lack of A1 adenosine receptors augments diabetic hyperfiltration and glomerular injury. J Am Soc Nephrol 19(4):722-30. PubMed: 18256360MGI: J:149926
- Fort PE; Losiewicz MK; Pennathur S; Jefferson LS; Kimball SR; Abcouwer SF; Gardner TW. 2014. mTORC1-independent reduction of retinal protein synthesis in type 1 diabetes. Diabetes 63(9):3077-90. PubMed: 24740573MGI: J:229867
- Fox R; Kim HS; Reddick RL; Kujoth GC; Prolla TA; Tsutsumi S; Wada Y; Smithies O; Maeda N. 2011. Mitochondrial DNA polymerase editing mutation, PolgD257A, reduces the diabetic phenotype of Akita male mice by suppressing appetite. Proc Natl Acad Sci U S A 108(21):8779-84. PubMed: 21555558MGI: J:171899
- Fox TE; Bewley MC; Unrath KA; Pedersen MM; Anderson RE; Jung DY; Jefferson LS; Kim JK; Bronson SK; Flanagan JM; Kester M. 2011. Circulating sphingolipid biomarkers in models of type 1 diabetes. J Lipid Res 52(3):509-17. PubMed: 21068007MGI: J:170277
- Fragiadaki M; Hill N; Hewitt R; Bou-Gharios G; Cook T; Tam FW; Domin J; Mason RM. 2012. Hyperglycemia causes renal cell damage via CCN2-induced activation of the TrkA receptor: implications for diabetic nephropathy. Diabetes 61(9):2280-8. PubMed: 22586581MGI: J:208460
- Gambhir D; Ananth S; Veeranan-Karmegam R; Elangovan S; Hester S; Jennings E; Offermanns S; Nussbaum JJ; Smith SB; Thangaraju M; Ganapathy V; Martin PM. 2012. GPR109A as an anti-inflammatory receptor in retinal pigment epithelial cells and its relevance to diabetic retinopathy. Invest Ophthalmol Vis Sci 53(4):2208-17. PubMed: 22427566MGI: J:196849
- Gao J; Wang Y; Zhao X; Chen P; Xie L. 2015. MicroRNA-204-5p-Mediated Regulation of SIRT1 Contributes to the Delay of Epithelial Cell Cycle Traversal in Diabetic Corneas. Invest Ophthalmol Vis Sci 56(3):1493-504. PubMed: 25613939MGI: J:230981
- Gastinger MJ; Kunselman AR; Conboy EE; Bronson SK; Barber AJ. 2008. Dendrite remodeling and other abnormalities in the retinal ganglion cells of Ins2 Akita diabetic mice. Invest Ophthalmol Vis Sci 49(6):2635-42. PubMed: 18515593MGI: J:137045
- Gastinger MJ; Singh RS; Barber AJ. 2006. Loss of cholinergic and dopaminergic amacrine cells in streptozotocin-diabetic rat and Ins2Akita-diabetic mouse retinas. Invest Ophthalmol Vis Sci 47(7):3143-50. PubMed: 16799061MGI: J:112243
- Grasemann C; Devlin MJ; Rzeczkowska PA; Herrmann R; Horsthemke B; Hauffa BP; Grynpas M; Alm C; Bouxsein ML; Palmert MR. 2012. Parental diabetes: the Akita mouse as a model of the effects of maternal and paternal hyperglycemia in wildtype offspring. PLoS One 7(11):e50210. PubMed: 23209676MGI: J:195000
- Grutzmacher C; Park S; Zhao Y; Morrison ME; Sheibani N; Sorenson CM. 2013. Aberrant production of extracellular matrix proteins and dysfunction in kidney endothelial cells with a short duration of diabetes. Am J Physiol Renal Physiol 304(1):F19-30. PubMed: 23077100MGI: J:191244
- Guo C; Zhang Z; Zhang P; Makita J; Kawada H; Blessing K; Kador PF. 2014. Novel transgenic mouse models develop retinal changes associated with early diabetic retinopathy similar to those observed in rats with diabetes mellitus. Exp Eye Res 119:77-87. PubMed: 24370601MGI: J:210369
- Gupta I; Cahoon J; Zhang X; Jones AD; Ahmed F; Uehara H; Messenger W; Ambati BK. 2015. In vivo ZW800-microbead imaging of retinal and choroidal vascular leakage in mice. Exp Eye Res 134:155-8. PubMed: 25536533MGI: J:230273
- Gupta S; McGrath B; Cavener DR. 2010. PERK (EIF2AK3) regulates proinsulin trafficking and quality control in the secretory pathway. Diabetes 59(8):1937-47. PubMed: 20530744MGI: J:169638
- Gurel Z; Sieg KM; Shallow KD; Sorenson CM; Sheibani N. 2013. Retinal O-linked N-acetylglucosamine protein modifications: implications for postnatal retinal vascularization and the pathogenesis of diabetic retinopathy. Mol Vis 19:1047-59. PubMed: 23734074MGI: J:203213
- Gurley SB; Clare SE; Snow KP; Hu A; Meyer TW; Coffman TM. 2006. Impact of genetic background on nephropathy in diabetic mice. Am J Physiol Renal Physiol 290(1):F214-22. PubMed: 16118394MGI: J:104083
- Gurley SB; Mach CL; Stegbauer J; Yang J; Snow KP; Hu A; Meyer TW; Coffman TM. 2010. Influence of genetic background on albuminuria and kidney injury in Ins2(+/C96Y) (Akita) mice. Am J Physiol Renal Physiol 298(3):F788-95. PubMed: 20042456MGI: J:157873
- Gyurko R; Siqueira CC; Caldon N; Gao L; Kantarci A; Van Dyke TE. 2006. Chronic hyperglycemia predisposes to exaggerated inflammatory response and leukocyte dysfunction in Akita mice. J Immunol 177(10):7250-6. PubMed: 17082643MGI: J:140617
- Ha JH; Sei Y; Basile AS. 1995. Striatal met-enkephalin and substance P levels are decreased in mice infected with the LP-BM5 murine leukemia virus. J Neurochem 64(4):1896-8. PubMed: 7534338MGI: J:23782
- Ha Y; Dun Y; Thangaraju M; Duplantier J; Dong Z; Liu K; Ganapathy V; Smith SB. 2011. Sigma receptor 1 modulates endoplasmic reticulum stress in retinal neurons. Invest Ophthalmol Vis Sci 52(1):527-40. PubMed: 20811050MGI: J:171562
- Han Z; Guo J; Conley SM; Naash MI. 2013. Retinal angiogenesis in the Ins2(Akita) mouse model of diabetic retinopathy. Invest Ophthalmol Vis Sci 54(1):574-84. PubMed: 23221078MGI: J:214574
- Haseyama T; Fujita T; Hirasawa F; Tsukada M; Wakui H; Komatsuda A; Ohtani H; Miura AB; Imai H; Koizumi A. 2002. Complications of IgA nephropathy in a non-insulin-dependent diabetes model, the Akita mouse. Tohoku J Exp Med 198(4):233-44. PubMed: 12630555MGI: J:107880
- Hathaway CK; Gasim AM; Grant R; Chang AS; Kim HS; Madden VJ; Bagnell CR Jr; Jennette JC; Smithies O; Kakoki M. 2015. Low TGFbeta1 expression prevents and high expression exacerbates diabetic nephropathy in mice. Proc Natl Acad Sci U S A 112(18):5815-20. PubMed: 25902541MGI: J:221419
- Hien TT; Turczynska KM; Dahan D; Ekman M; Grossi M; Sjogren J; Nilsson J; Braun T; Boettger T; Garcia-Vaz E; Stenkula K; Sward K; Gomez MF; Albinsson S. 2016. Elevated Glucose Levels Promote Contractile and Cytoskeletal Gene Expression in Vascular Smooth Muscle via Rho/Protein Kinase C and Actin Polymerization. J Biol Chem 291(7):3552-68. PubMed: 26683376MGI: J:231038
- Hirosawa M; Minata M; Harada KH; Hitomi T; Krust A; Koizumi A. 2008. Ablation of estrogen receptor alpha (ERalpha) prevents upregulation of POMC by leptin and insulin. Biochem Biophys Res Commun 371(2):320-3. PubMed: 18439911MGI: J:136249
- Hodish I; Absood A; Liu L; Liu M; Haataja L; Larkin D; Al-Khafaji A; Zaki A; Arvan P. 2011. In vivo misfolding of proinsulin below the threshold of frank diabetes. Diabetes 60(8):2092-101. PubMed: 21677281MGI: J:186814
- Hombrebueno JR; Chen M; Penalva RG; Xu H. 2014. Loss of synaptic connectivity, particularly in second order neurons is a key feature of diabetic retinal neuropathy in the Ins2Akita mouse. PLoS One 9(5):e97970. PubMed: 24848689MGI: J:216322
- Hong EG; Jung DY; Ko HJ; Zhang Z; Ma Z; Jun JY; Kim JH; Sumner AD; Vary TC; Gardner TW; Bronson SK; Kim JK. 2007. Nonobese, insulin-deficient Ins2Akita mice develop type 2 diabetes phenotypes including insulin resistance and cardiac remodeling. Am J Physiol Endocrinol Metab 293(6):E1687-96. PubMed: 17911348MGI: J:130021
- Howard AC; McNeil AK; Xiong F; Xiong WC; McNeil PL. 2011. A novel cellular defect in diabetes: membrane repair failure. Diabetes 60(11):3034-43. PubMed: 21940783MGI: J:189473
- Howell SJ; Mekhail MN; Azem R; Ward NL; Kern TS. 2013. Degeneration of retinal ganglion cells in diabetic dogs and mice: relationship to glycemic control and retinal capillary degeneration. Mol Vis 19:1413-21. PubMed: 23825921MGI: J:200768
- Hu Y; Chen Y; Ding L; He X; Takahashi Y; Gao Y; Shen W; Cheng R; Chen Q; Qi X; Boulton ME; Ma JX. 2013. Pathogenic role of diabetes-induced PPAR-alpha down-regulation in microvascular dysfunction. Proc Natl Acad Sci U S A 110(38):15401-6. PubMed: 24003152MGI: J:201158
- Huang H; Gandhi JK; Zhong X; Wei Y; Gong J; Duh EJ; Vinores SA. 2011. TNFalpha is required for late BRB breakdown in diabetic retinopathy, and its inhibition prevents leukostasis and protects vessels and neurons from apoptosis. Invest Ophthalmol Vis Sci 52(3):1336-44. PubMed: 21212173MGI: J:171543
- Huang H; He J; Johnson D; Wei Y; Liu Y; Wang S; Lutty GA; Duh EJ; Semba RD. 2015. Deletion of placental growth factor prevents diabetic retinopathy and is associated with Akt activation and HIF1alpha-VEGF pathway inhibition. Diabetes 64(1):200-12. PubMed: 25187372MGI: J:230203
- Imai A; Toriyama Y; Iesato Y; Hirabayashi K; Sakurai T; Kamiyoshi A; Ichikawa-Shindo Y; Kawate H; Tanaka M; Liu T; Xian X; Zhai L; Dai K; Tanimura K; Liu T; Cui N; Yamauchi A; Murata T; Shindo T. 2017. Adrenomedullin Suppresses Vascular Endothelial Growth Factor-Induced Vascular Hyperpermeability and Inflammation in Retinopathy. Am J Pathol 187(5):999-1015. PubMed: 28322199MGI: J:242032
- Iwakura H; Akamizu T; Ariyasu H; Irako T; Hosoda K; Nakao K; Kangawa K. 2007. Effects of ghrelin administration on decreased growth hormone status in obese animals. Am J Physiol Endocrinol Metab 293(3):E819-25. PubMed: 17595213MGI: J:125421
- Izumi T; Yokota-Hashimoto H; Zhao S; Wang J; Halban PA; Takeuchi T. 2003. Dominant negative pathogenesis by mutant proinsulin in the Akita diabetic mouse. Diabetes 52(2):409-16. PubMed: 12540615MGI: J:107156
- Jaholkowski P; Mierzejewski P; Zatorski P; Scinska A; Sienkiewicz-Jarosz H; Kaczmarek L; Samochowiec J; Filipkowski RK; Bienkowski P. 2011. Increased ethanol intake and preference in cyclin D2 knockout mice. Genes Brain Behav 10(5):551-6. PubMed: 21429093MGI: J:185702
- Johnson LA; Kim HS; Knudson MJ; Nipp CT; Yi X; Maeda N. 2013. Diabetic atherosclerosis in APOE*4 mice: synergy between lipoprotein metabolism and vascular inflammation. J Lipid Res 54(2):386-96. PubMed: 23204275MGI: J:193106
- Jun JY; Ma Z; Segar L. 2011. Spontaneously diabetic Ins2(+/Akita):apoE-deficient mice exhibit exaggerated hypercholesterolemia and atherosclerosis. Am J Physiol Endocrinol Metab 301(1):E145-54. PubMed: 21447785MGI: J:182074
- Kador PF; Zhang P; Makita J; Zhang Z; Guo C; Randazzo J; Kawada H; Haider N; Blessing K. 2012. Novel diabetic mouse models as tools for investigating diabetic retinopathy. PLoS One 7(12):e49422. PubMed: 23251343MGI: J:195671
- Kakoki M; Sullivan KA; Backus C; Hayes JM; Oh SS; Hua K; Gasim AM; Tomita H; Grant R; Nossov SB; Kim HS; Jennette JC; Feldman EL; Smithies O. 2010. Lack of both bradykinin B1 and B2 receptors enhances nephropathy, neuropathy, and bone mineral loss in Akita diabetic mice. Proc Natl Acad Sci U S A 107(22):10190-5. PubMed: 20479236MGI: J:161075
- Kayo T; Koizumi A. 1998. Mapping of murine diabetogenic gene mody on chromosome 7 at D7Mit258 and its involvement in pancreatic islet and beta cell development during the perinatal period. J Clin Invest 101(10):2112-8. PubMed: 9593767MGI: J:47883
- Kern TS; Tang J; Berkowitz BA. 2010. Validation of structural and functional lesions of diabetic retinopathy in mice. Mol Vis 16:2121-31. PubMed: 21139688MGI: J:168105
- Kezic JM; Chen X; Rakoczy EP; McMenamin PG. 2013. The effects of age and Cx3cr1 deficiency on retinal microglia in the Ins2(Akita) diabetic mouse. Invest Ophthalmol Vis Sci 54(1):854-63. PubMed: 23307960MGI: J:214564
- Kikawa K; Sakano D; Shiraki N; Tsuyama T; Kume K; Endo F; Kume S. 2014. Beneficial effect of insulin treatment on islet transplantation outcomes in Akita mice. PLoS One 9(4):e95451. PubMed: 24743240MGI: J:215198
- Kim ST; Moley KH. 2008. Paternal effect on embryo quality in diabetic mice is related to poor sperm quality and associated with decreased glucose transporter expression. Reproduction 136(3):313-22. PubMed: 18558660MGI: J:145654
- Kobayashi H; Yamazaki S; Takashima S; Liu W; Okuda H; Yan J; Fujii Y; Hitomi T; Harada KH; Habu T; Koizumi A. 2013. Ablation of Rnf213 retards progression of diabetes in the Akita mouse. Biochem Biophys Res Commun 432(3):519-25. PubMed: 23410753MGI: J:200802
- Krause MP; Al-Sajee D; D'Souza DM; Rebalka IA; Moradi J; Riddell MC; Hawke TJ. 2013. Impaired macrophage and satellite cell infiltration occurs in a muscle-specific fashion following injury in diabetic skeletal muscle. PLoS One 8(8):e70971. PubMed: 23951058MGI: J:205890
- Krause MP; Moradi J; Nissar AA; Riddell MC; Hawke TJ. 2011. Inhibition of plasminogen activator inhibitor-1 restores skeletal muscle regeneration in untreated type 1 diabetic mice. Diabetes 60(7):1964-72. PubMed: 21593201MGI: J:186757
- Krishnan M; Janardhanan P; Roman L; Reddick RL; Natarajan M; van Haperen R; Habib SL; de Crom R; Mohan S. 2015. Enhancing eNOS activity with simultaneous inhibition of IKKbeta restores vascular function in Ins2(Akita+/-) type-1 diabetic mice. Lab Invest 95(10):1092-104. PubMed: 26214584MGI: J:226515
- Kuramoto K; Sakai F; Yoshinori N; Nakamura TY; Wakabayashi S; Kojidani T; Haraguchi T; Hirose F; Osumi T. 2014. Deficiency of a lipid droplet protein, perilipin 5, suppresses myocardial lipid accumulation, thereby preventing type 1 diabetes-induced heart malfunction. Mol Cell Biol 34(14):2721-31. PubMed: 24820416MGI: J:223685
- LaRocca TJ; Fabris F; Chen J; Benhayon D; Zhang S; McCollum L; Schecter AD; Cheung JY; Sobie EA; Hajjar RJ; Lebeche D. 2012. Na+/Ca2+ exchanger-1 protects against systolic failure in the Akitains2 model of diabetic cardiomyopathy via a CXCR4/NF-kappaB pathway. Am J Physiol Heart Circ Physiol 303(3):H353-67. PubMed: 22610174MGI: J:189027
- Le NT; Heo KS; Takei Y; Lee H; Woo CH; Chang E; McClain C; Hurley C; Wang X; Li F; Xu H; Morrell C; Sullivan MA; Cohen MS; Serafimova IM; Taunton J; Fujiwara K; Abe J. 2013. A crucial role for p90RSK-mediated reduction of ERK5 transcriptional activity in endothelial dysfunction and atherosclerosis. Circulation 127(4):486-99. PubMed: 23243209MGI: J:210137
- Lee AH; Heidtman K; Hotamisligil GS; Glimcher LH. 2011. Dual and opposing roles of the unfolded protein response regulated by IRE1{alpha} and XBP1 in proinsulin processing and insulin secretion. Proc Natl Acad Sci U S A 108(21):8885-90. PubMed: 21555585MGI: J:171889
- Lee J; Harris AN; Holley CL; Mahadevan J; Pyles KD; Lavagnino Z; Scherrer DE; Fujiwara H; Sidhu R; Zhang J; Huang SC; Piston DW; Remedi MS; Urano F; Ory DS; Schaffer JE. 2016. Rpl13a small nucleolar RNAs regulate systemic glucose metabolism. J Clin Invest 126(12):4616-4625. PubMed: 27820699MGI: J:237822
- Lerner AG; Upton JP; Praveen PV; Ghosh R; Nakagawa Y; Igbaria A; Shen S; Nguyen V; Backes BJ; Heiman M; Heintz N; Greengard P; Hui S; Tang Q; Trusina A; Oakes SA; Papa FR. 2012. IRE1alpha Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death under Irremediable ER Stress. Cell Metab 16(2):250-64. PubMed: 22883233MGI: J:187377
- Li J; Wang JJ; Yu Q; Wang M; Zhang SX. 2009. Endoplasmic reticulum stress is implicated in retinal inflammation and diabetic retinopathy. FEBS Lett 583(9):1521-7. PubMed: 19364508MGI: J:148021
- Liu GC; Fang F; Zhou J; Koulajian K; Yang S; Lam L; Reich HN; John R; Herzenberg AM; Giacca A; Oudit GY; Scholey JW. 2012. Deletion of p47 ( phox ) attenuates the progression of diabetic nephropathy and reduces the severity of diabetes in the Akita mouse. Diabetologia 55(9):2522-32. PubMed: 22653270MGI: J:186435
- Liu J; Gao BB; Clermont AC; Blair P; Chilcote TJ; Sinha S; Flaumenhaft R; Feener EP. 2011. Hyperglycemia-induced cerebral hematoma expansion is mediated by plasma kallikrein. Nat Med 17(2):206-10. PubMed: 21258336MGI: J:168556
- Liu Z; Tanabe K; Bernal-Mizrachi E; Permutt MA. 2008. Mice with beta cell overexpression of glycogen synthase kinase-3beta have reduced beta cell mass and proliferation. Diabetologia 51(4):623-31. PubMed: 18219478MGI: J:137936
- Lo CS; Chang SY; Chenier I; Filep JG; Ingelfinger JR; Zhang SL; Chan JS. 2012. Heterogeneous nuclear ribonucleoprotein F suppresses angiotensinogen gene expression and attenuates hypertension and kidney injury in diabetic mice. Diabetes 61(10):2597-608. PubMed: 22664958MGI: J:208538
- Lo CS; Liu F; Shi Y; Maachi H; Chenier I; Godin N; Filep JG; Ingelfinger JR; Zhang SL; Chan JS. 2012. Dual RAS blockade normalizes angiotensin-converting enzyme-2 expression and prevents hypertension and tubular apoptosis in Akita angiotensinogen-transgenic mice. Am J Physiol Renal Physiol 302(7):F840-52. PubMed: 22205225MGI: J:182441
- Lo CS; Shi Y; Chang SY; Abdo S; Chenier I; Filep JG; Ingelfinger JR; Zhang SL; Chan JS. 2015. Overexpression of heterogeneous nuclear ribonucleoprotein F stimulates renal Ace-2 gene expression and prevents TGF-beta1-induced kidney injury in a mouse model of diabetes. Diabetologia 58(10):2443-54. PubMed: 26232095MGI: J:226424
- Lorenzen J; Shah R; Biser A; Staicu SA; Niranjan T; Garcia AM; Gruenwald A; Thomas DB; Shatat IF; Supe K; Woroniecki RP; Susztak K. 2008. The role of osteopontin in the development of albuminuria. J Am Soc Nephrol 19(5):884-90. PubMed: 18443355MGI: J:150239
- Losiewicz MK; Fort PE. 2011. Diabetes impairs the neuroprotective properties of retinal alpha-crystallins. Invest Ophthalmol Vis Sci 52(9):5034-42. PubMed: 21467180MGI: J:181425
- Lu A; Miao M; Schoeb TR; Agarwal A; Murphy-Ullrich JE. 2011. Blockade of TSP1-Dependent TGF-beta Activity Reduces Renal Injury and Proteinuria in a Murine Model of Diabetic Nephropathy. Am J Pathol 178(6):2573-86. PubMed: 21641382MGI: J:173296
- Lu YC; Sternini C; Rozengurt E; Zhukova E. 2005. Release of transgenic human insulin from gastric g cells: a novel approach for the amelioration of diabetes. Endocrinology 146(6):2610-9. PubMed: 15731364MGI: J:99270
- Lu Z; Jiang YP; Xu XH; Ballou LM; Cohen IS; Lin RZ. 2007. Decreased L-type Ca2+ current in cardiac myocytes of type 1 diabetic Akita mice due to reduced phosphatidylinositol 3-kinase signaling. Diabetes 56(11):2780-9. PubMed: 17666471MGI: J:126727
- Martens GW; Arikan MC; Lee J; Ren F; Greiner D; Kornfeld H. 2007. Tuberculosis susceptibility of diabetic mice. Am J Respir Cell Mol Biol 37(5):518-24. PubMed: 17585110MGI: J:141650
- Mathews CE; Langley SH; Leiter EH. 2002. New mouse model to study islet transplantation in insulin-dependent diabetes mellitus. Transplantation 73(8):1333-6. PubMed: 11981430MGI: J:76224
- Matsuda T; Kido Y; Asahara S; Kaisho T; Tanaka T; Hashimoto N; Shigeyama Y; Takeda A; Inoue T; Shibutani Y; Koyanagi M; Hosooka T; Matsumoto M; Inoue H; Uchida T; Koike M; Uchiyama Y; Akira S; Kasuga M. 2010. Ablation of C/EBPbeta alleviates ER stress and pancreatic beta cell failure through the GRP78 chaperone in mice. J Clin Invest 120(1):115-26. PubMed: 19955657MGI: J:156725
- McBride JD; Jenkins AJ; Liu X; Zhang B; Lee K; Berry WL; Janknecht R; Griffin CT; Aston CE; Lyons TJ; Tomasek JJ; Ma JX. 2014. Elevated circulation levels of an antiangiogenic SERPIN in patients with diabetic microvascular complications impair wound healing through suppression of Wnt signaling. J Invest Dermatol 134(6):1725-34. PubMed: 24463424MGI: J:210841
- McLenachan S; Magno AL; Ramos D; Catita J; McMenamin PG; Chen FK; Rakoczy EP; Ruberte J. 2015. Angiography reveals novel features of the retinal vasculature in healthy and diabetic mice. Exp Eye Res 138:6-21. PubMed: 26122048MGI: J:230772
- Mishra PK; Givvimani S; Metreveli N; Tyagi SC. 2010. Attenuation of beta2-adrenergic receptors and homocysteine metabolic enzymes cause diabetic cardiomyopathy. Biochem Biophys Res Commun 401(2):175-81. PubMed: 20836991MGI: J:165848
- Mitchell T; Johnson MS; Ouyang X; Chacko BK; Mitra K; Lei X; Gai Y; Moore DR; Barnes S; Zhang J; Koizumi A; Ramanadham S; Darley-Usmar VM. 2013. Dysfunctional mitochondrial bioenergetics and oxidative stress in Akita(+/Ins2)-derived beta-cells. Am J Physiol Endocrinol Metab 305(5):E585-99. PubMed: 23820623MGI: J:203191
- Mochida T; Tanaka T; Shiraki Y; Tajiri H; Matsumoto S; Shimbo K; Ando T; Nakamura K; Okamoto M; Endo F. 2011. Time-dependent changes in the plasma amino acid concentration in diabetes mellitus. Mol Genet Metab 103(4):406-9. PubMed: 21636301MGI: J:174793
- Morris SM Jr; Gao T; Cooper TK; Kepka-Lenhart D; Awad AS. 2011. Arginase-2 mediates diabetic renal injury. Diabetes 60(11):3015-22. PubMed: 21926276MGI: J:189484
- Muir ER; Renteria RC; Duong TQ. 2012. Reduced ocular blood flow as an early indicator of diabetic retinopathy in a mouse model of diabetes. Invest Ophthalmol Vis Sci 53(10):6488-94. PubMed: 22915034MGI: J:214062
- Murray AR; Chen Q; Takahashi Y; Zhou KK; Park K; Ma JX. 2013. MicroRNA-200b downregulates oxidation resistance 1 (Oxr1) expression in the retina of type 1 diabetes model. Invest Ophthalmol Vis Sci 54(3):1689-97. PubMed: 23404117MGI: J:214916
- Nagareddy PR; Murphy AJ; Stirzaker RA; Hu Y; Yu S; Miller RG; Ramkhelawon B; Distel E; Westerterp M; Huang LS; Schmidt AM; Orchard TJ; Fisher EA; Tall AR; Goldberg IJ. 2013. Hyperglycemia promotes myelopoiesis and impairs the resolution of atherosclerosis. Cell Metab 17(5):695-708. PubMed: 23663738MGI: J:199272
- Nagasu H; Satoh M; Kiyokage E; Kidokoro K; Toida K; Channon KM; Kanwar YS; Sasaki T; Kashihara N. 2016. Activation of endothelial NAD(P)H oxidase accelerates early glomerular injury in diabetic mice. Lab Invest 96(1):25-36. PubMed: 26552047MGI: J:228069
- Nasrallah R; Xiong H; Hebert RL. 2007. Renal prostaglandin E2 receptor (EP) expression profile is altered in streptozotocin and B6-Ins2Akita type I diabetic mice. Am J Physiol Renal Physiol 292(1):F278-84. PubMed: 16954344MGI: J:118086
- Natarajan M; Konopinski R; Krishnan M; Roman L; Bera A; Hongying Z; Habib SL; Mohan S. 2015. Inhibitor-kappaB kinase attenuates Hsp90-dependent endothelial nitric oxide synthase function in vascular endothelial cells. Am J Physiol Cell Physiol 308(8):C673-83. PubMed: 25652452MGI: J:224012
- Nicholas SB; Liu J; Kim J; Ren Y; Collins AR; Nguyen L; Hsueh WA. 2010. Critical role for osteopontin in diabetic nephropathy. Kidney Int 77(7):588-600. PubMed: 20130530MGI: J:184276
- Nozaki J; Kubota H; Yoshida H; Naitoh M; Goji J; Yoshinaga T; Mori K; Koizumi A; Nagata K. 2004. The endoplasmic reticulum stress response is stimulated through the continuous activation of transcription factors ATF6 and XBP1 in Ins2+/Akita pancreatic beta cells. Genes Cells 9(3):261-70. PubMed: 15005713MGI: J:96748
- Okamoto K; Honda K; Doi K; Ishizu T; Katagiri D; Wada T; Tomita K; Ohtake T; Kaneko T; Kobayashi S; Nangaku M; Tokunaga K; Noiri E. 2015. Glypican-5 Increases Susceptibility to Nephrotic Damage in Diabetic Kidney. Am J Pathol 185(7):1889-98. PubMed: 25987249MGI: J:223300
- Okamoto K; Iwasaki N; Doi K; Noiri E; Iwamoto Y; Uchigata Y; Fujita T; Tokunaga K. 2012. Inhibition of glucose-stimulated insulin secretion by KCNJ15, a newly identified susceptibility gene for type 2 diabetes. Diabetes 61(7):1734-41. PubMed: 22566534MGI: J:203172
- Oudit GY; Liu GC; Zhong J; Basu R; Chow FL; Zhou J; Loibner H; Janzek E; Schuster M; Penninger JM; Herzenberg AM; Kassiri Z; Scholey JW. 2010. Human recombinant ACE2 reduces the progression of diabetic nephropathy. Diabetes 59(2):529-38. PubMed: 19934006MGI: J:164158
- Oyadomari S; Koizumi A; Takeda K; Gotoh T; Akira S; Araki E; Mori M. 2002. Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes. J Clin Invest 109(4):525-32. PubMed: 11854325MGI: J:74700
- Oyadomari S; Yun C; Fisher EA; Kreglinger N; Kreibich G; Oyadomari M; Harding HP; Goodman AG; Harant H; Garrison JL; Taunton J; Katze MG; Ron D. 2006. Cotranslocational degradation protects the stressed endoplasmic reticulum from protein overload. Cell 126(4):727-39. PubMed: 16923392MGI: J:115988
- Park HJ; Zhang Y; Du C; Welzig CM; Madias C; Aronovitz MJ; Georgescu SP; Naggar I; Wang B; Kim YB; Blaustein RO; Karas RH; Liao R; Mathews CE; Galper JB. 2009. Role of SREBP-1 in the development of parasympathetic dysfunction in the hearts of type 1 diabetic Akita mice. Circ Res 105(3):287-94. PubMed: 19423844MGI: J:164764
- Patel VB; Bodiga S; Basu R; Das SK; Wang W; Wang Z; Lo J; Grant MB; Zhong J; Kassiri Z; Oudit GY. 2012. Loss of angiotensin-converting enzyme-2 exacerbates diabetic cardiovascular complications and leads to systolic and vascular dysfunction: a critical role of the angiotensin II/AT1 receptor axis. Circ Res 110(10):1322-35. PubMed: 22474255MGI: J:212515
- Pearson T; Shultz LD; Lief J; Burzenski L; Gott B; Chase T; Foreman O; Rossini AA; Bottino R; Trucco M; Greiner DL. 2008. A new immunodeficient hyperglycaemic mouse model based on the Ins2 ( Akita ) mutation for analyses of human islet and beta stem and progenitor cell function. Diabetologia 51(8):1449-56. PubMed: 18563383MGI: J:138005
- Pendse AA; Johnson LA; Tsai YS; Maeda N. 2010. Pparg-P465L mutation worsens hyperglycemia in Ins2-Akita female mice via adipose-specific insulin resistance and storage dysfunction. Diabetes 59(11):2890-7. PubMed: 20724579MGI: J:169338
- Pfister F; Feng Y; vom Hagen F; Hoffmann S; Molema G; Hillebrands JL; Shani M; Deutsch U; Hammes HP. 2008. Pericyte migration: a novel mechanism of pericyte loss in experimental diabetic retinopathy. Diabetes 57(9):2495-502. PubMed: 18559662MGI: J:141775
- Proctor G; Jiang T; Iwahashi M; Wang Z; Li J; Levi M. 2006. Regulation of renal fatty acid and cholesterol metabolism, inflammation, and fibrosis in Akita and OVE26 mice with type 1 diabetes. Diabetes 55(9):2502-9. PubMed: 16936198MGI: J:116591
- Pulinilkunnil T; Kienesberger PC; Nagendran J; Waller TJ; Young ME; Kershaw EE; Korbutt G; Haemmerle G; Zechner R; Dyck JR. 2013. Myocardial adipose triglyceride lipase overexpression protects diabetic mice from the development of lipotoxic cardiomyopathy. Diabetes 62(5):1464-77. PubMed: 23349479MGI: J:208574
- Queisser MA; Yao D; Geisler S; Hammes HP; Lochnit G; Schleicher ED; Brownlee M; Preissner KT. 2010. Hyperglycemia impairs proteasome function by methylglyoxal. Diabetes 59(3):670-8. PubMed: 20009088MGI: J:164153
- Rajab M; Jin H; Welzig CM; Albano A; Aronovitz M; Zhang Y; Park HJ; Link MS; Noujaim SF; Galper JB. 2013. Increased inducibility of ventricular tachycardia and decreased heart rate variability in a mouse model for type 1 diabetes: effect of pravastatin. Am J Physiol Heart Circ Physiol 305(12):H1807-16. PubMed: 24163078MGI: J:207722
- Rakoczy EP; Ali Rahman IS; Binz N; Li CR; Vagaja NN; de Pinho M; Lai CM. 2010. Characterization of a mouse model of hyperglycemia and retinal neovascularization. Am J Pathol 177(5):2659-70. PubMed: 20829433MGI: J:166270
- Ron D. 2002. Proteotoxicity in the endoplasmic reticulum: lessons from the Akita diabetic mouse. J Clin Invest 109(4):443-5. PubMed: 11854314MGI: J:78863
- Rubin A; Salzberg AC; Imamura Y; Grivitishvilli A; Tombran-Tink J. 2016. Identification of novel targets of diabetic nephropathy and PEDF peptide treatment using RNA-seq. BMC Genomics 17(1):936. PubMed: 27855634MGI: J:239407
- Rudchenko A; Akude E; Cooper E. 2014. Synapses on sympathetic neurons and parasympathetic neurons differ in their vulnerability to diabetes. J Neurosci 34(26):8865-74. PubMed: 24966386MGI: J:212541
- Salem ES; Grobe N; Elased KM. 2014. Insulin treatment attenuates renal ADAM17 and ACE2 shedding in diabetic Akita mice. Am J Physiol Renal Physiol 306(6):F629-39. PubMed: 24452639MGI: J:207415
- Schmidt RE; Feng D; Wang Q; Green KG; Snipes LL; Yamin M; Brines M. 2011. Effect of insulin and an erythropoietin-derived peptide (ARA290) on established neuritic dystrophy and neuronopathy in Akita (Ins2 Akita) diabetic mouse sympathetic ganglia. Exp Neurol 232(2):126-35. PubMed: 21872588MGI: J:178385
- Schmidt RE; Green KG; Snipes LL; Feng D. 2009. Neuritic dystrophy and neuronopathy in Akita (Ins2(Akita)) diabetic mouse sympathetic ganglia. Exp Neurol 216(1):207-18. PubMed: 19111542MGI: J:146204
- Schoeller EL; Albanna G; Frolova AI; Moley KH. 2012. Insulin rescues impaired spermatogenesis via the hypothalamic-pituitary-gonadal axis in Akita diabetic mice and restores male fertility. Diabetes 61(7):1869-78. PubMed: 22522616MGI: J:203174
- Schoeller EL; Chi M; Drury A; Bertschinger A; Esakky P; Moley KH. 2014. Leptin monotherapy rescues spermatogenesis in male Akita type 1 diabetic mice. Endocrinology 155(8):2781-6. PubMed: 24840347MGI: J:214314
- Schrufer TL; Antonetti DA; Sonenberg N; Kimball SR; Gardner TW; Jefferson LS. 2010. Ablation of 4E-BP1/2 prevents hyperglycemia-mediated induction of VEGF expression in the rodent retina and in Muller cells in culture. Diabetes 59(9):2107-16. PubMed: 20547975MGI: J:169349
- Sharma RB; O'Donnell AC; Stamateris RE; Ha B; McCloskey KM; Reynolds PR; Arvan P; Alonso LC. 2015. Insulin demand regulates beta cell number via the unfolded protein response. J Clin Invest 125(10):3831-46. PubMed: 26389675MGI: J:226393
- Shi Y; Lo CS; Chenier I; Maachi H; Filep JG; Ingelfinger JR; Zhang SL; Chan JS. 2013. Overexpression of catalase prevents hypertension and tubulointerstitial fibrosis and normalization of renal angiotensin-converting enzyme-2 expression in Akita mice. Am J Physiol Renal Physiol 304(11):F1335-46. PubMed: 23552863MGI: J:197243
- Shirakawa J; Togashi Y; Sakamoto E; Kaji M; Tajima K; Orime K; Inoue H; Kubota N; Kadowaki T; Terauchi Y. 2013. Glucokinase activation ameliorates ER stress-induced apoptosis in pancreatic beta-cells. Diabetes 62(10):3448-58. PubMed: 23801577MGI: J:208951
- Sklavos MM; Bertera S; Tse HM; Bottino R; He J; Beilke JN; Coulombe MG; Gill RG; Crapo JD; Trucco M; Piganelli JD. 2010. Redox modulation protects islets from transplant-related injury. Diabetes 59(7):1731-8. PubMed: 20413509MGI: J:169646
- Smith SB; Duplantier J; Dun Y; Mysona B; Roon P; Martin PM; Ganapathy V. 2008. In vivo protection against retinal neurodegeneration by sigma receptor 1 ligand (+)-pentazocine. Invest Ophthalmol Vis Sci 49(9):4154-61. PubMed: 18469181MGI: J:141696
- Soto I; Howell GR; John CW; Kief JL; Libby RT; John SW. 2014. DBA/2J Mice Are Susceptible to Diabetic Nephropathy and Diabetic Exacerbation of IOP Elevation. PLoS One 9(9):e107291. PubMed: 25207540MGI: J:213912
- Takeshita S; Kitayama S; Suzuki T; Moritani M; Inoue H; Itakura M. 2012. Diabetic modifier QTL, Dbm4, affecting elevated fasting blood glucose concentrations in congenic mice. Genes Genet Syst 87(5):341-6. PubMed: 23412636MGI: J:238044
- Takeshita S; Moritani M; Kunika K; Inoue H; Itakura M. 2006. Diabetic modifier QTLs identified in F2 intercrosses between Akita and A/J mice. Mamm Genome 17(9):927-40. PubMed: 16964447MGI: J:112869
- Tchekneva EE; Rinchik EM; Polosukhina D; Davis LS; Kadkina V; Mohamed Y; Dunn SR; Sharma K; Qi Z; Fogo AB; Breyer MD. 2007. A sensitized screen of N-ethyl-N-nitrosourea-mutagenized mice identifies dominant mutants predisposed to diabetic nephropathy. J Am Soc Nephrol 18(1):103-12. PubMed: 17151334MGI: J:135943
- Toque HA; Nunes KP; Yao L; Xu Z; Kondrikov D; Su Y; Webb RC; Caldwell RB; Caldwell RW. 2013. Akita spontaneously type 1 diabetic mice exhibit elevated vascular arginase and impaired vascular endothelial and nitrergic function. PLoS One 8(8):e72277. PubMed: 23977269MGI: J:206426
- Umino Y; Solessio E. 2013. Loss of scotopic contrast sensitivity in the optomotor response of diabetic mice. Invest Ophthalmol Vis Sci 54(2):1536-43. PubMed: 23287790MGI: J:214570
- Vagaja NN; Chinnery HR; Binz N; Kezic JM; Rakoczy EP; McMenamin PG. 2012. Changes in murine hyalocytes are valuable early indicators of ocular disease. Invest Ophthalmol Vis Sci 53(3):1445-51. PubMed: 22297487MGI: J:196754
- Vallon V; Gerasimova M; Rose MA; Masuda T; Satriano J; Mayoux E; Koepsell H; Thomson SC; Rieg T. 2014. SGLT2 inhibitor empagliflozin reduces renal growth and albuminuria in proportion to hyperglycemia and prevents glomerular hyperfiltration in diabetic Akita mice. Am J Physiol Renal Physiol 306(2):F194-204. PubMed: 24226524MGI: J:205116
- Vallon V; Rose M; Gerasimova M; Satriano J; Platt KA; Koepsell H; Cunard R; Sharma K; Thomson SC; Rieg T. 2013. Knockout of Na-glucose transporter SGLT2 attenuates hyperglycemia and glomerular hyperfiltration but not kidney growth or injury in diabetes mellitus. Am J Physiol Renal Physiol 304(2):F156-67. PubMed: 23152292MGI: J:192346
- Vashistha H; Singhal PC; Malhotra A; Husain M; Mathieson P; Saleem MA; Kuriakose C; Seshan S; Wilk A; Delvalle L; Peruzzi F; Giorgio M; Pelicci PG; Smithies O; Kim HS; Kakoki M; Reiss K; Meggs LG. 2012. Null mutations at the p66 and bradykinin 2 receptor loci induce divergent phenotypes in the diabetic kidney. Am J Physiol Renal Physiol 303(12):F1629-40. PubMed: 23019230MGI: J:190320
- Venegas-Pino DE; Wang PW; Stoute HK; Singh-Pickersgill NA; Hong BY; Khan MI; Shi Y; Werstuck GH. 2016. Sex-Specific Differences in an ApoE(-/-):Ins2(+/Akita) Mouse Model of Accelerated Atherosclerosis. Am J Pathol 186(1):67-77. PubMed: 26597883MGI: J:228139
- Wang CH; Li F; Hiller S; Kim HS; Maeda N; Smithies O; Takahashi N. 2011. A modest decrease in endothelial NOS in mice comparable to that associated with human NOS3 variants exacerbates diabetic nephropathy. Proc Natl Acad Sci U S A 108(5):2070-5. PubMed: 21245338MGI: J:169115
- Wang J; Chen Y; Yuan Q; Tang W; Zhang X; Osei K. 2011. Control of Precursor Maturation and Disposal Is an Early Regulative Mechanism in the Normal Insulin Production of Pancreatic beta-Cells. PLoS One 6(4):e19446. PubMed: 21559376MGI: J:172346
- Wang J; Osei K. 2011. Proinsulin maturation disorder is a contributor to the defect of subsequent conversion to insulin in beta-cells. Biochem Biophys Res Commun 411(1):150-5. PubMed: 21723250MGI: J:174771
- Wang J; Song MY; Lee JY; Kwon KS; Park BH. 2015. The NLRP3 inflammasome is dispensable for ER stress-induced pancreatic beta-cell damage in Akita mice. Biochem Biophys Res Commun 466(3):300-5. PubMed: 26361146MGI: J:232872
- Wang J; Takeuchi T; Tanaka S; Kubo SK; Kayo T; Lu D; Takata K; Koizumi A; Izumi T. 1999. A mutation in the insulin 2 gene induces diabetes with severe pancreatic beta-cell dysfunction in the Mody mouse. J Clin Invest 103(1):27-37. PubMed: 9884331MGI: J:51935
- Wang L; Tang Y; Eisner W; Sparks MA; Buckley AF; Spurney RF. 2014. Augmenting podocyte injury promotes advanced diabetic kidney disease in Akita mice. Biochem Biophys Res Commun 444(4):622-7. PubMed: 24491571MGI: J:218580
- Wang Q; Frolova AI; Purcell S; Adastra K; Schoeller E; Chi MM; Schedl T; Moley KH. 2010. Mitochondrial dysfunction and apoptosis in cumulus cells of type I diabetic mice. PLoS One 5(12):e15901. PubMed: 21209947MGI: J:168309
- Wang Y; Zhao X; Shi D; Chen P; Yu Y; Yang L; Xie L. 2013. Overexpression of SIRT1 promotes high glucose-attenuated corneal epithelial wound healing via p53 regulation of the IGFBP3/IGF-1R/AKT pathway. Invest Ophthalmol Vis Sci 54(5):3806-14. PubMed: 23661372MGI: J:215435
- Wende AR; Soto J; Olsen CD; Pires KM; Schell JC; Larrieu-Lahargue F; Litwin SE; Kakoki M; Takahashi N; Smithies O; Abel ED. 2010. Loss of Bradykinin Signaling Does Not Accelerate the Development of Cardiac Dysfunction in Type 1 Diabetic Akita Mice. Endocrinology :. PubMed: 20501666MGI: J:161074
- Winnay JN; Dirice E; Liew CW; Kulkarni RN; Kahn CR. 2014. p85alpha deficiency protects beta-cells from endoplasmic reticulum stress-induced apoptosis. Proc Natl Acad Sci U S A 111(3):1192-7. PubMed: 24395790MGI: J:206472
- Wisniewska-Kruk J; Klaassen I; Vogels IM; Magno AL; Lai CM; Van Noorden CJ; Schlingemann RO; Rakoczy EP. 2014. Molecular analysis of blood-retinal barrier loss in the Akimba mouse, a model of advanced diabetic retinopathy. Exp Eye Res 122:123-31. PubMed: 24703908MGI: J:229882
- Wong DW; Oudit GY; Reich H; Kassiri Z; Zhou J; Liu QC; Backx PH; Penninger JM; Herzenberg AM; Scholey JW. 2007. Loss of angiotensin-converting enzyme-2 (Ace2) accelerates diabetic kidney injury. Am J Pathol 171(2):438-51. PubMed: 17600118MGI: J:123932
- Wright WS; Yadav AS; McElhatten RM; Harris NR. 2012. Retinal blood flow abnormalities following six months of hyperglycemia in the Ins2(Akita) mouse. Exp Eye Res 98:9-15. PubMed: 22440813MGI: J:196847
- Wu X; Davis RC; McMillen TS; Schaeffer V; Zhou Z; Qi H; Mazandarani PN; Alialy R; Hudkins KL; Lusis AJ; LeBoeuf RC. 2014. Genetic modulation of diabetic nephropathy among mouse strains with Ins2 Akita mutation. Physiol Rep 2(11):. PubMed: 25428948MGI: J:228850
- Xu C; Zhu L; Chan T; Lu X; Shen W; Gillies MC; Zhou F. 2015. The altered renal and hepatic expression of solute carrier transporters (SLCs) in type 1 diabetic mice. PLoS One 10(3):e0120760. PubMed: 25789863MGI: J:229579
- Xu L; Hiller S; Simington S; Nickeleit V; Maeda N; James LR; Yi X. 2016. Influence of Different Levels of Lipoic Acid Synthase Gene Expression on Diabetic Nephropathy. PLoS One 11(10):e0163208. PubMed: 27706190MGI: J:236908
- Yamaguchi K; Takeda K; Kadowaki H; Ueda I; Namba Y; Ouchi Y; Nishitoh H; Ichijo H. 2013. Involvement of ASK1-p38 pathway in the pathogenesis of diabetes triggered by pancreatic ss cell exhaustion. Biochim Biophys Acta 1830(6):3656-63. PubMed: 23416061MGI: J:202436
- Yamaguchi S; Ishihara H; Yamada T; Tamura A; Usui M; Tominaga R; Munakata Y; Satake C; Katagiri H; Tashiro F; Aburatani H; Tsukiyama-Kohara K; Miyazaki J; Sonenberg N; Oka Y. 2008. ATF4-mediated induction of 4E-BP1 contributes to pancreatic beta cell survival under endoplasmic reticulum stress. Cell Metab 7(3):269-76. PubMed: 18316032MGI: J:133217
- Yamamoto Y; Miyatsuka T; Sasaki S; Miyashita K; Kubo F; Shimo N; Takebe S; Watada H; Kaneto H; Matsuoka TA; Shimomura I. 2017. Preserving expression of Pdx1 improves beta-cell failure in diabetic mice. Biochem Biophys Res Commun 483(1):418-424. PubMed: 28017717MGI: J:241963
- Yao Y; Jumabay M; Ly A; Radparvar M; Cubberly MR; Bostrom KI. 2013. A role for the endothelium in vascular calcification. Circ Res 113(5):495-504. PubMed: 23852538MGI: J:213371
- Yeh CK; Harris SE; Mohan S; Horn D; Fajardo R; Chun YH; Jorgensen J; Macdougall M; Abboud-Werner S. 2012. Hyperglycemia and xerostomia are key determinants of tooth decay in type 1 diabetic mice. Lab Invest 92(6):868-82. PubMed: 22449801MGI: J:184712
- Yoshioka M; Kayo T; Ikeda T; Koizumi A. 1997. A novel locus, Mody4, distal to D7Mit189 on chromosome 7 determines early-onset NIDDM in nonobese C57BL/6 (Akita) mutant mice. Diabetes 46(5):887-94. PubMed: 9133560MGI: J:40063
- Yu L; Su Y; Paueksakon P; Cheng H; Chen X; Wang H; Harris RC; Zent R; Pozzi A. 2012. Integrin alpha1/Akita double-knockout mice on a Balb/c background develop advanced features of human diabetic nephropathy. Kidney Int 81(11):1086-97. PubMed: 22297672MGI: J:198186
- Yuan Q; Tang W; Zhang X; Hinson JA; Liu C; Osei K; Wang J. 2012. Proinsulin atypical maturation and disposal induces extensive defects in mouse Ins2+/Akita beta-cells. PLoS One 7(4):e35098. PubMed: 22509386MGI: J:187092
- Zamakhchari MF; Sima C; Sama K; Fine N; Glogauer M; Van Dyke TE; Gyurko R. 2016. Lack of p47(phox) in Akita Diabetic Mice Is Associated with Interstitial Pneumonia, Fibrosis, and Oral Inflammation. Am J Pathol 186(3):659-70. PubMed: 26747235MGI: J:229928
- Zhang Y; Welzig CM; Picard KL; Du C; Wang B; Pan JQ; Kyriakis JM; Aronovitz MJ; Claycomb WC; Blanton RM; Park HJ; Galper JB. 2014. Glycogen synthase kinase-3beta inhibition ameliorates cardiac parasympathetic dysfunction in type 1 diabetic Akita mice. Diabetes 63(6):2097-113. PubMed: 24458356MGI: J:229284
- Zhou C; Pridgen B; King N; Xu J; Breslow JL. 2011. Hyperglycemic Ins2AkitaLdlr-/- mice show severely elevated lipid levels and increased atherosclerosis: a model of type 1 diabetic macrovascular disease. J Lipid Res 52(8):1483-93. PubMed: 21606463MGI: J:174983
- Zito E; Chin KT; Blais J; Harding HP; Ron D. 2010. ERO1-beta, a pancreas-specific disulfide oxidase, promotes insulin biogenesis and glucose homeostasis. J Cell Biol 188(6):821-32. PubMed: 20308425MGI: J:158805
- Zou MH; Li H; He C; Lin M; Lyons TJ; Xie Z. 2011. Tyrosine nitration of prostacyclin synthase is associated with enhanced retinal cell apoptosis in diabetes. Am J Pathol 179(6):2835-44. PubMed: 22015457MGI: J:180271
- Zuber C; Fan JY; Guhl B; Roth J. 2004. Misfolded proinsulin accumulates in expanded pre-Golgi intermediates and endoplasmic reticulum subdomains in pancreatic beta cells of Akita mice. FASEB J 18(7):917-9. PubMed: 15033933MGI: J:118471
- de Preux Charles AS; Verdier V; Zenker J; Peter B; Medard JJ; Kuntzer T; Beckmann JS; Bergmann S; Chrast R. 2010. Global transcriptional programs in peripheral nerve endoneurium and DRG are resistant to the onset of type 1 diabetic neuropathy in Ins2 mice. PLoS One 5(5):e10832. PubMed: 20520806MGI: J:160899