JAX
Mouse Strain Datasheet - 006860
B6.Cg-Ins2Akita Bdkrb2tm1Jfh/SmiJ
Also Known As: B6-Akita, B2R, B6-B2R, Akita
Mice homozygous for this targeted mutation of the bradykinin receptor, beta 2 (Bdkrb2) gene and heterozygous for the Akita spontaneous mutation of the insulin 2 (Ins2) gene (Ins2Akita) are viable and fertile. They are extremely diabetic, underweight, hyperphagic, polyuric, and have severe kidney, skeletal, and testicular defects. essentially no subcutaneous fat, and a significantly reduced lifespan. This strain may be used to research the kallikrein-kinin system, specifically the role of bradykinin B2 receptor in diabetes, oxidative stress, mitochondrial DNA damage, apoptosis, kidney morphology and function, and other senescence-associated phenotypes.
Donating Investigator
Dr. Masao Kakoki, University of North Carolina at Chapel H
Genetic overview
| Genetic Background | Generation |
|---|---|
|
000664 C57BL/6J |
|
Bdkrb2tm1Jfh
| Allele Type | Gene Symbol | Gene Name |
|---|---|---|
| Targeted (Null/Knockout) | Bdkrb2 | bradykinin receptor, beta 2 |
Ins2Akita
| Allele Type | Gene Symbol | Gene Name |
|---|---|---|
| Spontaneous | Ins2 | insulin II |
Research Applications
- Apoptosis Research
- Cancer Research
- Diabetes and Obesity Research
- Immunology, Inflammation and Autoimmunity Research
- Internal/Organ Research
- Cardiovascular Research
- Cell Biology Research
- Endocrine Deficiency Research
Detailed Description
Mice homozygous for the targeted mutation and heterozygous for the Ins2Akita spontaneous mutation are viable and fertile. Similar to mice only heterozygous for the Ins2Akita mutation, the double mutant mice are severely diabetic: their body weights are 70% of wildtype, they consume over 3-fold the normal amount of food, and their urinary output is approximately 20-fold more than that of wildtype mice. Double mutant mice have markedly enlarged kidneys. Urinary albumin excretion in double mutants is almost 4-fold that of either single mutant, and double mutants experience more severe nephropathy than mice that are heterozygous for the Akita mutation alone. Megsin and nephrin expression is markedly increased in double mutant mice when compared to wildtype or to mice with either single mutation alone. By 12 months of age, double mutant mice experience hair loss due to a reduction in hair follicle numbers and thinning of the dermis. Double mutants have essentially no subcutaneous fat, severe kyphosis, reduced bone density, osteoporosis, testicular atrophy, lipofuscin accumulation in the renal proximal tubule and testicular Leydig cells, increased apoptosis in the testicular seminiferous tubules and intestinal villi, and a significantly reduced lifespan.
This model is useful for studying the kallikrein-kinin system, specifically the role of bradykinin B2 receptor in diabetes, oxidative stress, mitochondrial DNA damage, apoptosis, morphological and functional kidney changes, and other senescence-associated phenotypes.
Development
Dr. Oliver Smithies laboratory backcrossed Stock No. 002641 B6;129S7-Bdkrb2tm1Jfh/J mice to C57BL/6J (Stock No. 000664) for an additional 6 generations prior to mating to Stock No. 003548 C57BL/6-Ins2Akita/J. In 2007, The Jackson Laboratory received C57BL/6 congenic males homozygous for the Bdkrb2tm1Jfh mutation at N9F? and mated them to heterozygous females from Stock No. 003548 C57BL/6-Ins2Akita/J. The strain has been maintained subsequently by brother x sister matings.
Genetic quality control completed at The Jackson Laboratory indicates that there is 129 genetic contamination on chromosomes 3, 4, 6, 11, 15 and 17 (006860 SNP's marker data)
Control Suggestions
Selected References
- Kakoki M; Kizer CM; Yi X; Takahashi N; Kim HS; Bagnell CR; Edgell CJ; Maeda N; Jennette JC; Smithies O. 2006. Senescence-associated phenotypes in Akita diabetic mice are enhanced by absence of bradykinin B2 receptors.. In: . . MGI: J:108948
- Kakoki M; McGarrah RW; Kim HS; Smithies O. 2007. Bradykinin B1 and B2 receptors both have protective roles in renal ischemia/reperfusion injury.. In: . . MGI: J:121339
- Kakoki M; Takahashi N; Jennette JC; Smithies O. 2004. Diabetic nephropathy is markedly enhanced in mice lacking the bradykinin B2 receptor.. In: . . MGI: J:92403
Bdkrb2tm1Jfh
Allele Symbol: Bdkrb2tm1Jfh
| Allele Name | targeted mutation 1, J Fred Hess |
|---|---|
| Allele Type | Targeted (Null/Knockout) |
| Allele Synonym(s) | B2-; B2-KO; B2R-; BdkrB2; Bk B2R-; Bk2r-; rB2 - |
| Gene Symbol and Name | Bdkrb2, bradykinin receptor, beta 2 |
| Gene Synonym(s) | B(2); B2; B2BKR; B2BRA; B2R; BK-2; BK2; BK2R; BKR2; BRB2; kinin B2 |
| Strain of Origin | 129S7/SvEvBrd-Hprt |
| Chromosome | 12 |
| Molecular Note | A neomycin selection cassette replaced the entire coding sequences of the gene. Binding assays on membranes prepared from ileum tissue of homozygous mice confirmed that no functional protein is produced from this allele. |
| Mutations Made By | Dr. J. Hess, Merck Research Laboratories |
Ins2Akita
Allele Symbol: Ins2Akita
| Allele Name | Akita |
|---|---|
| Allele Type | Spontaneous |
| Allele Synonym(s) | Akita; AkitaIns2; Ins2C96Y; Ins2Mody; Mody; Mody4 |
| Gene Symbol and Name | Ins2, insulin II |
| Gene Synonym(s) | AA986540; CP-II; IDDM; IDDM1; IDDM2; ILPR; IRDN; Ins-2; Ins-2; InsII; MODY10; Mody; Mody; Mody4; Mody4; expressed sequence AA986540; maturity onset diabetes of the young; maturity onset diabetes of the young 4 |
| Strain of Origin | C57BL/6NSlc |
| Chromosome | 7 |
| Molecular Note | In the mutant allele a transition from G to A at nucleotide 1907 disrupted an Fnu4HI site in exon 3. This mutation changed the seventh amino acid in the A chain of mature insulin, Cys96 (TGC), to Tyr (TAC). The authors predict that the transition would disrupt a disulfide bond between the A and the B chains and would likely induce a major conformational change in insulin 2 molecules. RT-PCR studies suggest that both normal and mutant Ins2 alleles are transcribed similarly in pancreatic islets of heterozygous mice, although immunofluorescence and immunoblot analyses of heterozygous islets detected reduced levels of insulin and proinsulin. |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Apoptosis Research
- Cancer Research
- Growth Factors/Receptors/Cytokines
- Osteoporosis
- Growth Factors/Receptors/Cytokines
- Diabetes and Obesity Research
- Hyperglycemia
- Hypoinsulinemia
- Impaired Insulin Processing
- Insulin Receptors and Growth Factors
- Type 1 Diabetes (IDDM)
- MODY, mature onset diabetes of the young
- Immunology, Inflammation and Autoimmunity Research
- Autoimmunity
- Type 1 Diabetes
- Inflammation
- Autoimmunity
- Internal/Organ Research
- Kidney Defects
- Skeleton
- Bone
Genotype: Bdkrb2tm1Jfh related
- Cardiovascular Research
- Hypertension
- diet-induced
- Hypertension
- Immunology, Inflammation and Autoimmunity Research
- Inflammation
Genotype: Ins2Akita related
- Cell Biology Research
- Protein Processing
- Diabetes and Obesity Research
- Hyperglycemia
- Hypoinsulinemia
- Impaired Insulin Processing
- Insulin Receptors and Growth Factors
- Islet Transplantation Studies
- Type 1 Diabetes (IDDM)
- MODY, mature onset diabetes of the young
- Endocrine Deficiency Research
- Pancreas Defects
Mammalian Phenotype Terms by Genotype
Genotype: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh Ins2Akita/Ins2+
B6.Cg-Ins2Akita Bdkrb2tm1Jfh
mortality/aging
- premature death
- mice have much shorter lifespan than wild-type; 909 days (wt) vs 246 days (mutant) (MGI Ref ID J:108948)
cellular phenotype
- abnormal mitochondrial chromosome morphology
- mutants display increased mitochondrial DNA damage compared to single mutants or wild-type mice at 12 months of age (MGI Ref ID J:108948)
- abnormal spermatogonia morphology
- in double mutant males, severe loss of spermatogonia is observed and atrophy of spermatic cords is prevalent at 12 months of age (MGI Ref ID J:108948)
endocrine/exocrine gland phenotype
- abnormal Leydig cell morphology
- double mutant males display numerous pigmented vacuoles in Leydig cells in the testes at 12 months of age (MGI Ref ID J:108948)
- abnormal seminiferous tubule morphology
- double mutants have an increased frequency of apoptotic cells in the seminiferous tubules at 12 months of age (MGI Ref ID J:108948)
reproductive system phenotype
- abnormal Leydig cell morphology
- double mutant males display numerous pigmented vacuoles in Leydig cells in the testes at 12 months of age (MGI Ref ID J:108948)
- abnormal seminiferous tubule morphology
- double mutants have an increased frequency of apoptotic cells in the seminiferous tubules at 12 months of age (MGI Ref ID J:108948)
- abnormal spermatogonia morphology
- in double mutant males, severe loss of spermatogonia is observed and atrophy of spermatic cords is prevalent at 12 months of age (MGI Ref ID J:108948)
digestive/alimentary phenotype
- abnormal intestinal epithelium morphology
- intestinal villi in mutants have a greater frequency of apoptotic cells (MGI Ref ID J:108948)
adipose tissue phenotype
- decreased subcutaneous adipose tissue amount
- mutants have almost no subcutaneous fat (MGI Ref ID J:108948)
skeleton phenotype
- decreased bone mineral density
- double mutants have significantly reduced bone density compared to wild-type or single mutant mice (MGI Ref ID J:108948)
- kyphosis
- double mutants exhibit marked kyphosis (MGI Ref ID J:108948)
integument phenotype
- alopecia
- most mutants show significant alopecia by 12 months of age (MGI Ref ID J:108948)
- decreased subcutaneous adipose tissue amount
- mutants have almost no subcutaneous fat (MGI Ref ID J:108948)
References
- Kakoki M; Kizer CM; Yi X; Takahashi N; Kim HS; Bagnell CR; Edgell CJ; Maeda N; Jennette JC; Smithies O. 2006. Senescence-associated phenotypes in Akita diabetic mice are enhanced by absence of bradykinin B2 receptors.. In: . . MGI: J:108948
- Kakoki M; McGarrah RW; Kim HS; Smithies O. 2007. Bradykinin B1 and B2 receptors both have protective roles in renal ischemia/reperfusion injury.. In: . . MGI: J:121339
- Kakoki M; Takahashi N; Jennette JC; Smithies O. 2004. Diabetic nephropathy is markedly enhanced in mice lacking the bradykinin B2 receptor.. In: . . MGI: J:92403
Additional - Bdkrb2tm1Jfh related
- Abadir PM; Carey RM; Siragy HM. 2003. Angiotensin AT2 receptors directly stimulate renal nitric oxide in bradykinin B2-receptor-null mice.. In: . . MGI: J:103114
- Adolfo Arganaraz G; Regina Perosa S; Cristina Lencioni E; Bader M; Abrao Cavalheiro E; da Graca Naffah-Mazzacoratti M; Bosco Pesquero J; Antonio Silva J Jr. 2004. Role of kinin B1 and B2 receptors in the development of pilocarpine model of epilepsy.. In: . . MGI: J:90943
- Alfie ME; Alim S; Mehta D; Shesely EG; Carretero OA. 1999. An enhanced effect of arginine vasopressin in bradykinin B2 receptor null mutant mice.. In: . . MGI: J:56192
- Alfie ME; Yang XP; Hess F; Carretero OA. 1996. Salt-sensitive hypertension in bradykinin B2 receptor knockout mice.. In: . . MGI: J:34497
- Aliberti J; Viola JP; Vieira-de-Abreu A; Bozza PT; Sher A; Scharfstein J. 2003. Cutting edge: Bradykinin induces IL-12 production by dendritic cells: a danger signal that drives Th1 polarization.. In: . . MGI: J:83453
- Barros CC; Haro A; Russo FJ; Schadock I; Almeida SS; Reis FC; Moraes MR; Haidar A; Hirata AE; Mori M; Bacurau RF; Wurtele M; Bader M; Pesquero JB; Araujo RC. 2012. Bradykinin inhibits hepatic gluconeogenesis in obese mice.. In: . . MGI: J:188609
- Bergaya S; Meneton P; Bloch-Faure M; Mathieu E; Alhenc-Gelas F; Levy BI; Boulanger CM. 2001. Decreased flow-dependent dilation in carotid arteries of tissue kallikrein-knockout mice.. In: . . MGI: J:115590
- Bernstein KE; Xiao HD; Frenzel K; Li P; Shen XZ; Adams JW; Fuchs S. 2005. Six truisms concerning ACE and the renin-angiotensin system educed from the genetic analysis of mice.. In: . . MGI: J:109628
- Bhagat TD; Zhou L; Sokol L; Kessel R; Caceres G; Gundabolu K; Tamari R; Gordon S; Mantzaris I; Jodlowski T; Yu Y; Jing X; Polineni R; Bhatia K; Pellagatti A; Boultwood J; Kambhampati S; Steidl U; Stein C; Ju W; Liu G; Kenny P; List A; Bitzer M; Verma A. 2013. miR-21 mediates hematopoietic suppression in MDS by activating TGF-beta signaling.. In: . . MGI: J:196470
- Blaes N; Pecher C; Mehrenberger M; Cellier E; Praddaude F; Chevalier J; Tack I; Couture R; Girolami JP. 2012. Bradykinin inhibits high glucose- and growth factor-induced collagen synthesis in mesangial cells through the B2-kinin receptor.. In: . . MGI: J:187019
- Borkowski JA; Ransom RW; Seabrook GR; Trumbauer M; Chen H; Hill RG; Strader CD; Hess JF. 1995. Targeted disruption of a B2 bradykinin receptor gene in mice eliminates bradykinin action in smooth muscle and neurons.. In: . . MGI: J:25953
- Brochu I; Labonte J; Bkaily G; D'Orleans-Juste P. 2002. Role of endothelin receptors in the hypertensive state of kinin B(2) knockout mice subjected to a high-salt diet.. In: . . MGI: J:103135
- Cervenka L; Harrison-Bernard LM; Dipp S; Primrose G; Imig JD; El-Dahr SS. 1999. Early onset salt-sensitive hypertension in bradykinin B(2) receptor null mice.. In: . . MGI: J:88466
- Cervenka L; Vaneckova I; Maly J; Horacek V; El-Dahr SS. 2003. Genetic inactivation of the B2 receptor in mice worsens two-kidney, one-clip hypertension: role of NO and the AT2 receptor.. In: . . MGI: J:106003
- Diehl SA; McElvany B; Noubade R; Seeberger N; Harding B; Spach K; Teuscher C. 2014. G proteins Galphai1/3 are critical targets for Bordetella pertussis toxin-induced vasoactive amine sensitization.. In: . . MGI: J:209809
- Duka I; Kintsurashvili E; Gavras I; Johns C; Bresnahan M; Gavras H. 2001. Vasoactive potential of the b(1) bradykinin receptor in normotension and hypertension.. In: . . MGI: J:115601
- Duka I; Shenouda S; Johns C; Kintsurashvili E; Gavras I; Gavras H. 2001. Role of the B(2) receptor of bradykinin in insulin sensitivity.. In: . . MGI: J:103241
- Dutra RC; Bento AF; Leite DF; Manjavachi MN; Marcon R; Bicca MA; Pesquero JB; Calixto JB. 2013. The role of kinin B1 and B2 receptors in the persistent pain induced by experimental autoimmune encephalomyelitis (EAE) in mice: evidence for the involvement of astrocytes.. In: . . MGI: J:197950
- Dutra RC; Leite DF; Bento AF; Manjavachi MN; Patricio ES; Figueiredo CP; Pesquero JB; Calixto JB. 2011. The role of kinin receptors in preventing neuroinflammation and its clinical severity during experimental autoimmune encephalomyelitis in mice.. In: . . MGI: J:201039
- El-Dahr SS; Aboudehen K; Dipp S. 2008. Bradykinin B2 receptor null mice harboring a Ser23-to-Ala substitution in the p53 gene are protected from renal dysgenesis.. In: . . MGI: J:140998
- El-Dahr SS; Harrison-Bernard LM; Dipp S; Yosipiv IV; Meleg-Smith S. 2000. Bradykinin B2 null mice are prone to renal dysplasia: gene-environment interactions in kidney development. In: . . MGI: J:65386
- Emanueli C; Fink E; Milia AF; Salis MB; Conti M; Demontis MP; Madeddu P. 1998. Enhanced blood pressure sensitivity to deoxycorticosterone in mice with disruption of bradykinin B2 receptor gene.. In: . . MGI: J:48384
- Emanueli C; Maestri R; Corradi D; Marchione R; Minasi A; Tozzi MG; Salis MB; Straino S; Capogrossi MC; Olivetti G; Madeddu P. 1999. Dilated and failing cardiomyopathy in bradykinin B(2) receptor knockout mice [see comments]. In: . . MGI: J:59835
- Fan H; Harrell JR; Dipp S; Saifudeen Z; El-Dahr SS. 2005. A novel pathological role of p53 in kidney development revealed by gene-environment interactions.. In: . . MGI: J:104678
- Fan H; Stefkova J; El-Dahr SS. 2006. Susceptibility to metanephric apoptosis in bradykinin B2 receptor null mice via the p53-Bax pathway.. In: . . MGI: J:111678
- Fang C; Stavrou E; Schmaier AA; Grobe N; Morris M; Chen A; Nieman MT; Adams GN; LaRusch G; Zhou Y; Bilodeau ML; Mahdi F; Warnock M; Schmaier AH. 2013. Angiotensin 1-7 and Mas decrease thrombosis in Bdkrb2-/- mice by increasing NO and prostacyclin to reduce platelet spreading and glycoprotein VI activation.. In: . . MGI: J:196472
- Ferreira J; Campos MM; Pesquero JB; Araujo RC; Bader M; Calixto JB. 2001. Evidence for the participation of kinins in Freund's adjuvant-induced inflammatory and nociceptive responses in kinin B1 and B2 receptor knockout mice.. In: . . MGI: J:179423
- Gobel K; Pankratz S; Asaridou CM; Herrmann AM; Bittner S; Merker M; Ruck T; Glumm S; Langhauser F; Kraft P; Krug TF; Breuer J; Herold M; Gross CC; Beckmann D; Korb-Pap A; Schuhmann MK; Kuerten S; Mitroulis I; Ruppert C; Nolte MW; Panousis C; Klotz L; Kehrel B; Korn T; Langer HF; Pap T; Nieswandt B; Wiendl H; Chavakis T; Kleinschnitz C; Meuth SG. 2016. Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells.. In: . . MGI: J:239929
- Han ED; MacFarlane RC; Mulligan AN; Scafidi J; Davis AE 3rd. 2002. Increased vascular permeability in C1 inhibitor-deficient mice mediated by the bradykinin type 2 receptor.. In: . . MGI: J:76090
- Harrison-Bernard LM; Dipp S; El-Dahr SS. 2003. Renal and blood pressure phenotype in 18-mo-old bradykinin B2R(-/-)CRD mice.. In: . . MGI: J:84494
- Hess JF; Chen RZ; Hey P; Breese R; Chang RS; Chen TB; Bock MG; Vogt T; Pettibone DJ. 2006. Generation and characterization of a humanized bradykinin B1 receptor mouse.. In: . . MGI: J:135789
- Hillmeister P; Gatzke N; Dulsner A; Bader M; Schadock I; Hoefer I; Hamann I; Infante-Duarte C; Jung G; Troidl K; Urban D; Stawowy P; Frentsch M; Li M; Nagorka S; Wang H; Shi Y; le Noble F; Buschmann I. 2011. Arteriogenesis is modulated by bradykinin receptor signaling.. In: . . MGI: J:186598
- Isbell DC; Voros S; Yang Z; DiMaria JM; Berr SS; French BA; Epstein FH; Bishop SP; Wang H; Roy RJ; Kemp BA; Matsubara H; Carey RM; Kramer CM. 2007. Interaction between bradykinin subtype 2 and angiotensin II type 2 receptors during post-MI left ventricular remodeling.. In: . . MGI: J:132208
- Jaffa MA; Kobeissy F; Al Hariri M; Chalhoub H; Eid A; Ziyadeh FN; Jaffa AA. 2012. Global renal gene expression profiling analysis in B2-kinin receptor null mice: impact of diabetes.. In: . . MGI: J:191871
- Kahn R; Hellmark T; Leeb-Lundberg LM; Akbari N; Todiras M; Olofsson T; Wieslander J; Christensson A; Westman K; Bader M; Muller-Esterl W; Karpman D. 2009. Neutrophil-derived proteinase 3 induces kallikrein-independent release of a novel vasoactive kinin.. In: . . MGI: J:149285
- Kakoki M; Sullivan KA; Backus C; Hayes JM; Oh SS; Hua K; Gasim AM; Tomita H; Grant R; Nossov SB; Kim HS; Jennette JC; Feldman EL; Smithies O. 2010. Lack of both bradykinin B1 and B2 receptors enhances nephropathy, neuropathy, and bone mineral loss in Akita diabetic mice.. In: . . MGI: J:161075
- Krankel N; Kuschnerus K; Muller M; Speer T; Mocharla P; Madeddu P; Bader M; Luscher TF; Landmesser U. 2013. Novel insights into the critical role of bradykinin and the kinin B2 receptor for vascular recruitment of circulating endothelial repair-promoting mononuclear cell subsets: alterations in patients with coronary disease.. In: . . MGI: J:210277
- Lu F; Chauhan AK; Fernandes SM; Walsh MT; Wagner DD; Davis AE 3rd. 2008. The effect of C1 inhibitor on intestinal ischemia and reperfusion injury.. In: . . MGI: J:142529
- Madeddu P; Emanueli C; Gaspa L; Salis B; Milia AF; Chao L; Chao J. 1999. Role of the bradykinin B2 receptor in the maturation of blood pressure phenotype: lesson from transgenic and knockout mice. In: . . MGI: J:59794
- Madeddu P; Emanueli C; Maestri R; Salis MB; Minasi A; Capogrossi MC; Olivetti G. 2000. Angiotensin II type 1 receptor blockade prevents cardiac remodeling in bradykinin B(2) receptor knockout mice. In: . . MGI: J:60047
- Madeddu P; Salis MB; Emanueli C. 1999. Altered baroreflex control of heart rate in bradykinin B2-receptor knockout mice. In: . . MGI: J:59776
- Madeddu P; Varoni MV; Palomba D; Emanueli C; Demontis MP; Glorioso N; Dessi-Fulgheri P; Sarzani R; Anania V. 1997. Cardiovascular phenotype of a mouse strain with disruption of bradykinin B2-receptor gene.. In: . . MGI: J:112265
- Maestri R; Milia AF; Salis MB; Graiani G; Lagrasta C; Monica M; Corradi D; Emanueli C; Madeddu P. 2003. Cardiac hypertrophy and microvascular deficit in kinin B2 receptor knockout mice.. In: . . MGI: J:103026
- Maul B; Krause W; Pankow K; Becker M; Gembardt F; Alenina N; Walther T; Bader M; Siems WE. 2005. Central angiotensin II controls alcohol consumption via its AT1 receptor.. In: . . MGI: J:101196
- Milia AF; Gross V; Plehm R; De Silva JA Jr; Bader M; Luft FC. 2001. Normal blood pressure and renal function in mice lacking the bradykinin B(2) receptor.. In: . . MGI: J:103234
- Monteiro AC; Schmitz V; Svensjo E; Gazzinelli RT; Almeida IC; Todorov A; de Arruda LB; Torrecilhas AC; Pesquero JB; Morrot A; Bouskela E; Bonomo A; Lima AP; Muller-Esterl W; Scharfstein J. 2006. Cooperative activation of TLR2 and bradykinin B2 receptor is required for induction of type 1 immunity in a mouse model of subcutaneous infection by Trypanosoma cruzi.. In: . . MGI: J:140513
- Picard N; Eladari D; El Moghrabi S; Planes C; Bourgeois S; Houillier P; Wang Q; Burnier M; Deschenes G; Knepper MA; Meneton P; Chambrey R. 2008. Defective ENaC processing and function in tissue kallikrein-deficient mice.. In: . . MGI: J:132178
- Prediger RD; Medeiros R; Pandolfo P; Duarte FS; Passos GF; Pesquero JB; Campos MM; Calixto JB; Takahashi RN. 2008. Genetic deletion or antagonism of kinin B(1) and B(2) receptors improves cognitive deficits in a mouse model of Alzheimer's disease.. In: . . MGI: J:135258
- Rhaleb NE; Peng H; Alfie ME; Shesely EG; Carretero OA. 1999. Effect of ACE inhibitor on DOCA-salt- and aortic coarctation-induced hypertension in mice: do kinin B2 receptors play a role?. In: . . MGI: J:53680
- Rodi D; Buzzi A; Barbieri M; Zucchini S; Verlengia G; Binaschi A; Regoli D; Boschi A; Ongali B; Couture R; Simonato M. 2013. Bradykinin B receptors increase hippocampal excitability and susceptibility to seizures in mice.. In: . . MGI: J:207053
- Rodrigues ES; Martin RP; Felipe SA; Bader M; Oliveira SM; Shimuta SI. 2009. Cross talk between kinin and angiotensin II receptors in mouse abdominal aorta.. In: . . MGI: J:164962
- Rupniak NM; Boyce S; Webb JK; Williams AR; Carlson EJ; Hill RG ; Borkowski JA ; Hess JF. 1997. Effects of the bradykinin B1 receptor antagonist des-Arg9[Leu8]bradykinin and genetic disruption of the B2 receptor on nociception in rats and mice.. In: . . MGI: J:41328
- Sanchez de Miguel L; Neysari S; Jakob S; Petrimpol M; Butz N; Banfi A; Zaugg CE; Humar R; Battegay EJ. 2008. B2-kinin receptor plays a key role in B1-, angiotensin converting enzyme inhibitor-, and vascular endothelial growth factor-stimulated in vitro angiogenesis in the hypoxic mouse heart.. In: . . MGI: J:161893
- Schanstra JP; Bachvarova M; Neau E; Bascands JL; Bachvarov D. 2007. Gene expression profiling in the remnant kidney model of wild type and kinin B1 and B2 receptor knockout mice.. In: . . MGI: J:152886
- Schanstra JP; Duchene J; Praddaude F; Bruneval P; Tack I; Chevalier J; Girolami JP; Bascands JL. 2003. Decreased renal NO excretion and reduced glomerular tuft area in mice lacking the bradykinin B2 receptor.. In: . . MGI: J:83895
- Schanstra JP; Neau E; Drogoz P; Arevalo Gomez MA; Lopez Novoa JM; Calise D; Pecher C; Bader M; Girolami JP; Bascands JL. 2002. In vivo bradykinin B2 receptor activation reduces renal fibrosis.. In: . . MGI: J:78354
- Shariat-Madar Z; Mahdi F; Warnock M; Homeister JW; Srikanth S; Krijanovski Y; Murphey LJ; Jaffa AA; Schmaier AH. 2006. Bradykinin B2 receptor knockout mice are protected from thrombosis by increased nitric oxide and prostacyclin.. In: . . MGI: J:135575
- Silvestre JS; Bergaya S; Tamarat R; Duriez M; Boulanger CM; Levy BI. 2001. Proangiogenic effect of angiotensin-converting enzyme inhibition is mediated by the bradykinin B(2) receptor pathway.. In: . . MGI: J:115630
- Song JJ; Hwang I; Cho KH; Garcia MA; Kim AJ; Wang TH; Lindstrom TM; Lee AT; Nishimura T; Zhao L; Morser J; Nesheim M; Goodman SB; Lee DM; Bridges SL Jr; Gregersen PK; Leung LL; Robinson WH. 2011. Plasma carboxypeptidase B downregulates inflammatory responses in autoimmune arthritis.. In: . . MGI: J:178261
- Strecker T; Messlinger K; Weyand M; Reeh PW. 2005. Role of different proton-sensitive channels in releasing calcitonin gene-related peptide from isolated hearts of mutant mice.. In: . . MGI: J:101967
- Tan Y; Keum JS; Wang B; McHenry MB; Lipsitz SR; Jaffa AA. 2007. Targeted deletion of B2-kinin receptors protects against the development of diabetic nephropathy.. In: . . MGI: J:142936
- Trabold F; Pons S; Hagege AA; Bloch-Faure M; Alhenc-Gelas F; Giudicelli JF; Richer-Giudicelli C; Meneton P. 2002. Cardiovascular phenotypes of kinin B2 receptor- and tissue kallikrein-deficient mice.. In: . . MGI: J:103162
- Trevisani M; Schmidlin F; Tognetto M; Nijkamp FP; Gies JP; Frossard N; Amadesi S; Folkerts G; Geppetti P. 1999. Evidence for in vitro expression of B1 receptor in the mouse trachea and urinary bladder.. In: . . MGI: J:54390
- Vashistha H; Singhal PC; Malhotra A; Husain M; Mathieson P; Saleem MA; Kuriakose C; Seshan S; Wilk A; Delvalle L; Peruzzi F; Giorgio M; Pelicci PG; Smithies O; Kim HS; Kakoki M; Reiss K; Meggs LG. 2012. Null mutations at the p66 and bradykinin 2 receptor loci induce divergent phenotypes in the diabetic kidney.. In: . . MGI: J:190320
- Wang H; Kohno T; Amaya F; Brenner GJ; Ito N; Allchorne A; Ji RR; Woolf CJ. 2005. Bradykinin produces pain hypersensitivity by potentiating spinal cord glutamatergic synaptic transmission.. In: . . MGI: J:100473
- Xi L; Das A; Zhao ZQ; Merino VF; Bader M; Kukreja RC. 2008. Loss of myocardial ischemic postconditioning in adenosine A1 and bradykinin B2 receptors gene knockout mice.. In: . . MGI: J:158042
- Xia CF; Smith RS Jr; Shen B; Yang ZR; Borlongan CV; Chao L; Chao J. 2006. Postischemic brain injury is exacerbated in mice lacking the kinin B2 receptor.. In: . . MGI: J:135763
- Xiao HD; Fuchs S; Cole JM; Disher KM; Sutliff RL; Bernstein KE. 2003. Role of bradykinin in angiotensin-converting enzyme knockout mice.. In: . . MGI: J:83894
- Yang XP; Liu YH; Mehta D; Cavasin MA; Shesely E; Xu J; Liu F; Carretero OA. 2001. Diminished cardioprotective response to inhibition of angiotensin-converting enzyme and angiotensin II type 1 receptor in B(2) kinin receptor gene knockout mice.. In: . . MGI: J:111458
- Yosipiv IV; Dipp S; El-Dahr SS. 2001. Targeted disruption of the bradykinin B(2) receptor gene in mice alters the ontogeny of the renin-angiotensin system.. In: . . MGI: J:72552
- Zaika O; Zhang J; Shapiro MS. 2011. Functional role of M-type (KCNQ) K(+) channels in adrenergic control of cardiomyocyte contraction rate by sympathetic neurons.. In: . . MGI: J:185252
Additional - Ins2Akita related
- Abdo S; Shi Y; Otoukesh A; Ghosh A; Lo CS; Chenier I; Filep JG; Ingelfinger JR; Zhang SL; Chan JS. 2014. Catalase overexpression prevents nuclear factor erythroid 2-related factor 2 stimulation of renal angiotensinogen gene expression, hypertension, and kidney injury in diabetic mice.. In: . . MGI: J:229839
- Abudukadier A; Fujita Y; Obara A; Ohashi A; Fukushima T; Sato Y; Ogura M; Nakamura Y; Fujimoto S; Hosokawa M; Hasegawa H; Inagaki N. 2013. Tetrahydrobiopterin has a glucose-lowering effect by suppressing hepatic gluconeogenesis in an endothelial nitric oxide synthase-dependent manner in diabetic mice.. In: . . MGI: J:208962
- Aghdam SY; Gurel Z; Ghaffarieh A; Sorenson CM; Sheibani N. 2013. High glucose and diabetes modulate cellular proteasome function: Implications in the pathogenesis of diabetes complications.. In: . . MGI: J:198848
- Akimov NP; Renteria RC. 2012. Spatial frequency threshold and contrast sensitivity of an optomotor behavior are impaired in the Ins2Akita mouse model of diabetes.. In: . . MGI: J:180197
- Asakawa A; Toyoshima M; Inoue K; Koizumi A. 2007. Ins2Akita mice exhibit hyperphagia and anxiety behavior via the melanocortin system.. In: . . MGI: J:125256
- Awad AS; Kinsey GR; Khutsishvili K; Gao T; Bolton WK; Okusa MD. 2011. Monocyte/macrophage chemokine receptor CCR2 mediates diabetic renal injury.. In: . . MGI: J:180042
- Bachar-Wikstrom E; Wikstrom JD; Ariav Y; Tirosh B; Kaiser N; Cerasi E; Leibowitz G. 2013. Stimulation of autophagy improves endoplasmic reticulum stress-induced diabetes.. In: . . MGI: J:208584
- Barber AJ; Antonetti DA; Kern TS; Reiter CE; Soans RS; Krady JK; Levison SW; Gardner TW; Bronson SK. 2005. The Ins2Akita mouse as a model of early retinal complications in diabetes.. In: . . MGI: J:99412
- Basu R; Lee J; Wang Z; Patel VB; Fan D; Das SK; Liu GC; John R; Scholey JW; Oudit GY; Kassiri Z. 2012. Loss of TIMP3 selectively exacerbates diabetic nephropathy.. In: . . MGI: J:189948
- Basu R; Oudit GY; Wang X; Zhang L; Ussher JR; Lopaschuk GD; Kassiri Z. 2009. Type 1 diabetic cardiomyopathy in the Akita (Ins2WT/C96Y) mouse model is characterized by lipotoxicity and diastolic dysfunction with preserved systolic function.. In: . . MGI: J:158228
- Blum B; Roose AN; Barrandon O; Maehr R; Arvanites AC; Davidow LS; Davis JC; Peterson QP; Rubin LL; Melton DA. 2014. Reversal of beta cell de-differentiation by a small molecule inhibitor of the TGFbeta pathway.. In: . . MGI: J:218054
- Bostrom KI; Jumabay M; Matveyenko A; Nicholas SB; Yao Y. 2011. Activation of vascular bone morphogenetic protein signaling in diabetes mellitus.. In: . . MGI: J:183498
- Bugger H; Boudina S; Hu XX; Tuinei J; Zaha VG; Theobald HA; Yun UJ; McQueen AP; Wayment B; Litwin SE; Abel ED. 2008. Type 1 diabetic akita mouse hearts are insulin sensitive but manifest structurally abnormal mitochondria that remain coupled despite increased uncoupling protein 3.. In: . . MGI: J:142159
- Bugger H; Chen D; Riehle C; Soto J; Theobald HA; Hu XX; Ganesan B; Weimer BC; Abel ED. 2009. Tissue-specific remodeling of the mitochondrial proteome in type 1 diabetic akita mice.. In: . . MGI: J:154406
- Cerda-Esteban N; Naumann H; Ruzittu S; Mah N; Pongrac IM; Cozzitorto C; Hommel A; Andrade-Navarro MA; Bonifacio E; Spagnoli FM. 2017. Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2.. In: . . MGI: J:241373
- Chacko BK; Reily C; Srivastava A; Johnson MS; Ye Y; Ulasova E; Agarwal A; Zinn KR; Murphy MP; Kalyanaraman B; Darley-Usmar V. 2010. Prevention of diabetic nephropathy in Ins2(+/)(AkitaJ) mice by the mitochondria-targeted therapy MitoQ.. In: . . MGI: J:166866
- Chang AS; Dale AN; Moley KH. 2005. Maternal diabetes adversely affects preovulatory oocyte maturation, development, and granulosa cell apoptosis.. In: . . MGI: J:129826
- Chang JH; Paik SY; Mao L; Eisner W; Flannery PJ; Wang L; Tang Y; Mattocks N; Hadjadj S; Goujon JM; Ruiz P; Gurley SB; Spurney RF. 2012. Diabetic kidney disease in FVB/NJ Akita mice: temporal pattern of kidney injury and urinary nephrin excretion.. In: . . MGI: J:187110
- Chavali V; Tyagi SC; Mishra PK. 2012. MicroRNA-133a regulates DNA methylation in diabetic cardiomyocytes.. In: . . MGI: J:188036
- Chen H; Li J; Jiao L; Petersen RB; Li J; Peng A; Zheng L; Huang K. 2014. Apelin inhibits the development of diabetic nephropathy by regulating histone acetylation in Akita mouse.. In: . . MGI: J:217958
- Chen Q; Takahashi Y; Oka K; Ma JX. 2016. Functional Differences of Very-Low-Density Lipoprotein Receptor Splice Variants in Regulating Wnt Signaling.. In: . . MGI: J:236304
- Cheng L; Han X; Shi Y. 2009. A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.. In: . . MGI: J:159566
- Choeiri C; Hewitt K; Durkin J; Simard CJ; Renaud JM; Messier C. 2005. Longitudinal evaluation of memory performance and peripheral neuropathy in the Ins2(C96Y) Akita mice.. In: . . MGI: J:95284
- Denhez B; Lizotte F; Guimond MO; Jones N; Takano T; Geraldes P. 2015. Increased SHP-1 protein expression by high glucose levels reduces nephrin phosphorylation in podocytes.. In: . . MGI: J:218390
- Dennis MD; Schrufer TL; Bronson SK; Kimball SR; Jefferson LS. 2011. Hyperglycemia-Induced O-GlcNAcylation and Truncation of 4E-BP1 Protein in Liver of a Mouse Model of Type 1 Diabetes.. In: . . MGI: J:176719
- Dokun AO; Chen L; Lanjewar SS; Lye RJ; Annex BH. 2014. Glycaemic control improves perfusion recovery and VEGFR2 protein expression in diabetic mice following experimental PAD.. In: . . MGI: J:220054
- Drapeau N; Lizotte F; Denhez B; Guay A; Kennedy CR; Geraldes P. 2013. Expression of SHP-1 induced by hyperglycemia prevents insulin actions in podocytes.. In: . . MGI: J:198982
- Dugan LL; You YH; Ali SS; Diamond-Stanic M; Miyamoto S; DeCleves AE; Andreyev A; Quach T; Ly S; Shekhtman G; Nguyen W; Chepetan A; Le TP; Wang L; Xu M; Paik KP; Fogo A; Viollet B; Murphy A; Brosius F; Naviaux RK; Sharma K. 2013. AMPK dysregulation promotes diabetes-related reduction of superoxide and mitochondrial function.. In: . . MGI: J:204683
- Fang F; Bae EH; Hu A; Liu GC; Zhou X; Williams V; Maksimowski N; Lu C; Konvalinka A; John R; Scholey JW. 2015. Deletion of the gene for adiponectin accelerates diabetic nephropathy in the Ins2 (+/C96Y) mouse.. In: . . MGI: J:224619
- Fang RC; Kryger ZB; Buck DW 2nd; De la Garza M; Galiano RD; Mustoe TA. 2010. Limitations of the db/db mouse in translational wound healing research: Is the NONcNZO10 polygenic mouse model superior?. In: . . MGI: J:165705
- Faulhaber-Walter R; Chen L; Oppermann M; Kim SM; Huang Y; Hiramatsu N; Mizel D; Kajiyama H; Zerfas P; Briggs JP; Kopp JB; Schnermann J. 2008. Lack of A1 adenosine receptors augments diabetic hyperfiltration and glomerular injury.. In: . . MGI: J:149926
- Fort PE; Losiewicz MK; Pennathur S; Jefferson LS; Kimball SR; Abcouwer SF; Gardner TW. 2014. mTORC1-independent reduction of retinal protein synthesis in type 1 diabetes.. In: . . MGI: J:229867
- Fox R; Kim HS; Reddick RL; Kujoth GC; Prolla TA; Tsutsumi S; Wada Y; Smithies O; Maeda N. 2011. Mitochondrial DNA polymerase editing mutation, PolgD257A, reduces the diabetic phenotype of Akita male mice by suppressing appetite.. In: . . MGI: J:171899
- Fox TE; Bewley MC; Unrath KA; Pedersen MM; Anderson RE; Jung DY; Jefferson LS; Kim JK; Bronson SK; Flanagan JM; Kester M. 2011. Circulating sphingolipid biomarkers in models of type 1 diabetes.. In: . . MGI: J:170277
- Fragiadaki M; Hill N; Hewitt R; Bou-Gharios G; Cook T; Tam FW; Domin J; Mason RM. 2012. Hyperglycemia causes renal cell damage via CCN2-induced activation of the TrkA receptor: implications for diabetic nephropathy.. In: . . MGI: J:208460
- Gambhir D; Ananth S; Veeranan-Karmegam R; Elangovan S; Hester S; Jennings E; Offermanns S; Nussbaum JJ; Smith SB; Thangaraju M; Ganapathy V; Martin PM. 2012. GPR109A as an anti-inflammatory receptor in retinal pigment epithelial cells and its relevance to diabetic retinopathy.. In: . . MGI: J:196849
- Gao J; Wang Y; Zhao X; Chen P; Xie L. 2015. MicroRNA-204-5p-Mediated Regulation of SIRT1 Contributes to the Delay of Epithelial Cell Cycle Traversal in Diabetic Corneas.. In: . . MGI: J:230981
- Gastinger MJ; Kunselman AR; Conboy EE; Bronson SK; Barber AJ. 2008. Dendrite remodeling and other abnormalities in the retinal ganglion cells of Ins2 Akita diabetic mice.. In: . . MGI: J:137045
- Gastinger MJ; Singh RS; Barber AJ. 2006. Loss of cholinergic and dopaminergic amacrine cells in streptozotocin-diabetic rat and Ins2Akita-diabetic mouse retinas.. In: . . MGI: J:112243
- Grasemann C; Devlin MJ; Rzeczkowska PA; Herrmann R; Horsthemke B; Hauffa BP; Grynpas M; Alm C; Bouxsein ML; Palmert MR. 2012. Parental diabetes: the Akita mouse as a model of the effects of maternal and paternal hyperglycemia in wildtype offspring.. In: . . MGI: J:195000
- Grutzmacher C; Park S; Zhao Y; Morrison ME; Sheibani N; Sorenson CM. 2013. Aberrant production of extracellular matrix proteins and dysfunction in kidney endothelial cells with a short duration of diabetes.. In: . . MGI: J:191244
- Guo C; Zhang Z; Zhang P; Makita J; Kawada H; Blessing K; Kador PF. 2014. Novel transgenic mouse models develop retinal changes associated with early diabetic retinopathy similar to those observed in rats with diabetes mellitus.. In: . . MGI: J:210369
- Gupta I; Cahoon J; Zhang X; Jones AD; Ahmed F; Uehara H; Messenger W; Ambati BK. 2015. In vivo ZW800-microbead imaging of retinal and choroidal vascular leakage in mice.. In: . . MGI: J:230273
- Gupta S; McGrath B; Cavener DR. 2010. PERK (EIF2AK3) regulates proinsulin trafficking and quality control in the secretory pathway.. In: . . MGI: J:169638
- Gurel Z; Sieg KM; Shallow KD; Sorenson CM; Sheibani N. 2013. Retinal O-linked N-acetylglucosamine protein modifications: implications for postnatal retinal vascularization and the pathogenesis of diabetic retinopathy.. In: . . MGI: J:203213
- Gurley SB; Clare SE; Snow KP; Hu A; Meyer TW; Coffman TM. 2006. Impact of genetic background on nephropathy in diabetic mice.. In: . . MGI: J:104083
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- Gyurko R; Siqueira CC; Caldon N; Gao L; Kantarci A; Van Dyke TE. 2006. Chronic hyperglycemia predisposes to exaggerated inflammatory response and leukocyte dysfunction in Akita mice.. In: . . MGI: J:140617
- Ha JH; Sei Y; Basile AS. 1995. Striatal met-enkephalin and substance P levels are decreased in mice infected with the LP-BM5 murine leukemia virus.. In: . . MGI: J:23782
- Ha Y; Dun Y; Thangaraju M; Duplantier J; Dong Z; Liu K; Ganapathy V; Smith SB. 2011. Sigma receptor 1 modulates endoplasmic reticulum stress in retinal neurons.. In: . . MGI: J:171562
- Han Z; Guo J; Conley SM; Naash MI. 2013. Retinal angiogenesis in the Ins2(Akita) mouse model of diabetic retinopathy.. In: . . MGI: J:214574
- Haseyama T; Fujita T; Hirasawa F; Tsukada M; Wakui H; Komatsuda A; Ohtani H; Miura AB; Imai H; Koizumi A. 2002. Complications of IgA nephropathy in a non-insulin-dependent diabetes model, the Akita mouse.. In: . . MGI: J:107880
- Hathaway CK; Chang AS; Grant R; Kim HS; Madden VJ; Bagnell CR Jr; Jennette JC; Smithies O; Kakoki M. 2016. High Elmo1 expression aggravates and low Elmo1 expression prevents diabetic nephropathy.. In: . . MGI: J:230491
- Hathaway CK; Gasim AM; Grant R; Chang AS; Kim HS; Madden VJ; Bagnell CR Jr; Jennette JC; Smithies O; Kakoki M. 2015. Low TGFbeta1 expression prevents and high expression exacerbates diabetic nephropathy in mice.. In: . . MGI: J:221419
- Hien TT; Turczynska KM; Dahan D; Ekman M; Grossi M; Sjogren J; Nilsson J; Braun T; Boettger T; Garcia-Vaz E; Stenkula K; Sward K; Gomez MF; Albinsson S. 2016. Elevated Glucose Levels Promote Contractile and Cytoskeletal Gene Expression in Vascular Smooth Muscle via Rho/Protein Kinase C and Actin Polymerization.. In: . . MGI: J:231038
- Hirosawa M; Minata M; Harada KH; Hitomi T; Krust A; Koizumi A. 2008. Ablation of estrogen receptor alpha (ERalpha) prevents upregulation of POMC by leptin and insulin.. In: . . MGI: J:136249
- Hodish I; Absood A; Liu L; Liu M; Haataja L; Larkin D; Al-Khafaji A; Zaki A; Arvan P. 2011. In vivo misfolding of proinsulin below the threshold of frank diabetes.. In: . . MGI: J:186814
- Hombrebueno JR; Chen M; Penalva RG; Xu H. 2014. Loss of synaptic connectivity, particularly in second order neurons is a key feature of diabetic retinal neuropathy in the Ins2Akita mouse.. In: . . MGI: J:216322
- Hong EG; Jung DY; Ko HJ; Zhang Z; Ma Z; Jun JY; Kim JH; Sumner AD; Vary TC; Gardner TW; Bronson SK; Kim JK. 2007. Nonobese, insulin-deficient Ins2Akita mice develop type 2 diabetes phenotypes including insulin resistance and cardiac remodeling.. In: . . MGI: J:130021
- Howard AC; McNeil AK; Xiong F; Xiong WC; McNeil PL. 2011. A novel cellular defect in diabetes: membrane repair failure.. In: . . MGI: J:189473
- Howell SJ; Mekhail MN; Azem R; Ward NL; Kern TS. 2013. Degeneration of retinal ganglion cells in diabetic dogs and mice: relationship to glycemic control and retinal capillary degeneration.. In: . . MGI: J:200768
- Hu Y; Chen Y; Ding L; He X; Takahashi Y; Gao Y; Shen W; Cheng R; Chen Q; Qi X; Boulton ME; Ma JX. 2013. Pathogenic role of diabetes-induced PPAR-alpha down-regulation in microvascular dysfunction.. In: . . MGI: J:201158
- Huang H; Gandhi JK; Zhong X; Wei Y; Gong J; Duh EJ; Vinores SA. 2011. TNFalpha is required for late BRB breakdown in diabetic retinopathy, and its inhibition prevents leukostasis and protects vessels and neurons from apoptosis.. In: . . MGI: J:171543
- Huang H; He J; Johnson D; Wei Y; Liu Y; Wang S; Lutty GA; Duh EJ; Semba RD. 2015. Deletion of placental growth factor prevents diabetic retinopathy and is associated with Akt activation and HIF1alpha-VEGF pathway inhibition.. In: . . MGI: J:230203
- Imai A; Toriyama Y; Iesato Y; Hirabayashi K; Sakurai T; Kamiyoshi A; Ichikawa-Shindo Y; Kawate H; Tanaka M; Liu T; Xian X; Zhai L; Dai K; Tanimura K; Liu T; Cui N; Yamauchi A; Murata T; Shindo T. 2017. Adrenomedullin Suppresses Vascular Endothelial Growth Factor-Induced Vascular Hyperpermeability and Inflammation in Retinopathy.. In: . . MGI: J:242032
- Iwakura H; Akamizu T; Ariyasu H; Irako T; Hosoda K; Nakao K; Kangawa K. 2007. Effects of ghrelin administration on decreased growth hormone status in obese animals.. In: . . MGI: J:125421
- Izumi T; Yokota-Hashimoto H; Zhao S; Wang J; Halban PA; Takeuchi T. 2003. Dominant negative pathogenesis by mutant proinsulin in the Akita diabetic mouse.. In: . . MGI: J:107156
- Jaholkowski P; Mierzejewski P; Zatorski P; Scinska A; Sienkiewicz-Jarosz H; Kaczmarek L; Samochowiec J; Filipkowski RK; Bienkowski P. 2011. Increased ethanol intake and preference in cyclin D2 knockout mice.. In: . . MGI: J:185702
- Johnson LA; Kim HS; Knudson MJ; Nipp CT; Yi X; Maeda N. 2013. Diabetic atherosclerosis in APOE*4 mice: synergy between lipoprotein metabolism and vascular inflammation.. In: . . MGI: J:193106
- Jun JY; Ma Z; Segar L. 2011. Spontaneously diabetic Ins2(+/Akita):apoE-deficient mice exhibit exaggerated hypercholesterolemia and atherosclerosis.. In: . . MGI: J:182074
- Kador PF; Zhang P; Makita J; Zhang Z; Guo C; Randazzo J; Kawada H; Haider N; Blessing K. 2012. Novel diabetic mouse models as tools for investigating diabetic retinopathy.. In: . . MGI: J:195671
- Kakoki M; Sullivan KA; Backus C; Hayes JM; Oh SS; Hua K; Gasim AM; Tomita H; Grant R; Nossov SB; Kim HS; Jennette JC; Feldman EL; Smithies O. 2010. Lack of both bradykinin B1 and B2 receptors enhances nephropathy, neuropathy, and bone mineral loss in Akita diabetic mice.. In: . . MGI: J:161075
- Kayo T; Koizumi A. 1998. Mapping of murine diabetogenic gene mody on chromosome 7 at D7Mit258 and its involvement in pancreatic islet and beta cell development during the perinatal period.. In: . . MGI: J:47883
- Kern TS; Tang J; Berkowitz BA. 2010. Validation of structural and functional lesions of diabetic retinopathy in mice.. In: . . MGI: J:168105
- Kezic JM; Chen X; Rakoczy EP; McMenamin PG. 2013. The effects of age and Cx3cr1 deficiency on retinal microglia in the Ins2(Akita) diabetic mouse.. In: . . MGI: J:214564
- Kikawa K; Sakano D; Shiraki N; Tsuyama T; Kume K; Endo F; Kume S. 2014. Beneficial effect of insulin treatment on islet transplantation outcomes in Akita mice.. In: . . MGI: J:215198
- Kim ST; Moley KH. 2008. Paternal effect on embryo quality in diabetic mice is related to poor sperm quality and associated with decreased glucose transporter expression.. In: . . MGI: J:145654
- Kobayashi H; Yamazaki S; Takashima S; Liu W; Okuda H; Yan J; Fujii Y; Hitomi T; Harada KH; Habu T; Koizumi A. 2013. Ablation of Rnf213 retards progression of diabetes in the Akita mouse.. In: . . MGI: J:200802
- Krause MP; Al-Sajee D; D'Souza DM; Rebalka IA; Moradi J; Riddell MC; Hawke TJ. 2013. Impaired macrophage and satellite cell infiltration occurs in a muscle-specific fashion following injury in diabetic skeletal muscle.. In: . . MGI: J:205890
- Krause MP; Moradi J; Nissar AA; Riddell MC; Hawke TJ. 2011. Inhibition of plasminogen activator inhibitor-1 restores skeletal muscle regeneration in untreated type 1 diabetic mice.. In: . . MGI: J:186757
- Krishnan M; Janardhanan P; Roman L; Reddick RL; Natarajan M; van Haperen R; Habib SL; de Crom R; Mohan S. 2015. Enhancing eNOS activity with simultaneous inhibition of IKKbeta restores vascular function in Ins2(Akita+/-) type-1 diabetic mice.. In: . . MGI: J:226515
- Kuramoto K; Sakai F; Yoshinori N; Nakamura TY; Wakabayashi S; Kojidani T; Haraguchi T; Hirose F; Osumi T. 2014. Deficiency of a lipid droplet protein, perilipin 5, suppresses myocardial lipid accumulation, thereby preventing type 1 diabetes-induced heart malfunction.. In: . . MGI: J:223685
- LaRocca TJ; Fabris F; Chen J; Benhayon D; Zhang S; McCollum L; Schecter AD; Cheung JY; Sobie EA; Hajjar RJ; Lebeche D. 2012. Na+/Ca2+ exchanger-1 protects against systolic failure in the Akitains2 model of diabetic cardiomyopathy via a CXCR4/NF-kappaB pathway.. In: . . MGI: J:189027
- Le NT; Heo KS; Takei Y; Lee H; Woo CH; Chang E; McClain C; Hurley C; Wang X; Li F; Xu H; Morrell C; Sullivan MA; Cohen MS; Serafimova IM; Taunton J; Fujiwara K; Abe J. 2013. A crucial role for p90RSK-mediated reduction of ERK5 transcriptional activity in endothelial dysfunction and atherosclerosis.. In: . . MGI: J:210137
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