Chromosome 11 congenic mice are useful for identifying genes in the Idd4 region involved in diabetes.
T1DR Colony, The Jackson Laboratory
Chromosome 11 congenic mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities. The reported conclusion of diabetes resistance in this Chr 11 congenic has been re-evaluated now that the B6 contaminating genome on Chr 1 has been eliminated. Diabetes incidence studies performed at The Jackson Laboratory show an accelerated onset and incidence of diabetes in females when compared with NOD/ShiLtJ controls and the original stock 005311, while the diabetes onset and incidence in males is accelerated compared to the original Stock 005311 and is slightly reduced compared to NOD/ShiLtJ controls. 006809 incidence study and fine mapping data.
This strain may be useful for identifying genes involved with diabetes located within the Idd4 region of Chr 11.
Idd4 subloci map to Chr 11. Due to a genetic contamination identified in the Idd5 region of Chr 1, Stock No. 005311 was further backcrossed to Stock No. 001976 - NOD/ShiLtJ for 2 generations. Genetic Quality Control indicates all previously C57BL/6 identified Chr 1 markers and all other known Idd's are of NOD origin; while Chr 11 markers D11Nds1 (43.8 cM) through D11Mit41 (49 cM) are of C57BL/6 origin. This Idd4 congenic strain containing a 5.2cM region located between D11Nds1 and D11Mit41 of Chr 11 is known to contain Nos2 (45.6cM) Mpmv4 (48cM), Xmv42 (53cM), Mpo, (49cM) and the beta-chemokine gene family, including, Ccl1 (Tcr3, 47cM), Ccl2(Mcp1, 46.5cM), Ccl3 (Mip1a, 47.59cM), Ccl4 (Mip1b, 47.6cM) (Gill et al, 1995 and Grattan et al, 2002). In 2008 this congenic strain is at generation N3+N2F2.