NOD.B6-(D11Nds1-D11Mit41)/J

Stock number: 006809
Product name: NOD.Idd4A clean
Strain synonyms: NOD.B6-Idd4A
Research areas: Diabetes and Obesity Research, Immunology, Inflammation and Autoimmunity Research

Description

Chromosome 11 congenic mice are useful for identifying genes in the Idd4 region involved in diabetes.

Detailed description

Chromosome 11 congenic mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities. The reported conclusion of diabetes resistance in this Chr 11 congenic has been re-evaluated now that the B6 contaminating genome on Chr 1 has been eliminated. Diabetes incidence studies performed at The Jackson Laboratory show an accelerated onset and incidence of diabetes in females when compared with NOD/ShiLtJ controls and the original stock 005311, while the diabetes onset and incidence in males is accelerated compared to the original Stock 005311 and is slightly reduced compared to NOD/ShiLtJ controls. 006809 incidence study and fine mapping data.

In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. It should be noted that the phenotype could vary from that originally described on a NOD/ShiLt genetic background. We will modify the strain description if necessary as published results become available.

This strain may be useful for identifying genes involved with diabetes located within the Idd4 region of Chr 11.

Development

Idd4 subloci map to Chr 11. Due to a genetic contamination identified in the Idd5 region of Chr 1, Stock No. 005311 was further backcrossed to Stock No. 001976 - NOD/ShiLtJ for 2 generations. Genetic Quality Control indicates all previously C57BL/6 identified Chr 1 markers and all other known Idd's are of NOD origin; while Chr 11 markers D11Nds1 (43.8 cM) through D11Mit41 (49 cM) are of C57BL/6 origin. This Idd4 congenic strain containing a 5.2cM region located between D11Nds1 and D11Mit41 of Chr 11 is known to contain Nos2 (45.6cM) Mpmv4 (48cM), Xmv42 (53cM), Mpo, (49cM) and the beta-chemokine gene family, including, Ccl1 (Tcr3, 47cM), Ccl2(Mcp1, 46.5cM), Ccl3 (Mip1a, 47.59cM), Ccl4 (Mip1b, 47.6cM) (Gill et al, 1995 and Grattan et al, 2002). In 2008 this congenic strain is at generation N3+N2F2.

Allele

MGI accession ID: MGI:89125
Marker symbol: D11Mit41
Marker name: DNA segment, Chr 11, Massachusetts Institute of Technology 41
Chromosome: 11

Allele

MGI accession ID: MGI:89264
Marker symbol: D11Nds1
Marker name: DNA segment, Chr 11, Nuffield Department of Surgery 1
Chromosome: 11

Allele

MGI accession ID: MGI:96406
Marker symbol: Idd4
Marker name: insulin dependent diabetes susceptibility 4
Chromosome: 11