This allele of <em>Or8a1</em> (formerly <em>Olfr151</em>) has five nucleotide substitutions in the promoter that alter both the homeodomain and the O/E-like binding site. Additionally there is a downstream IRES-tauLacZ cassette that is bicistronically expresssed. At 26 days of age homozygotes were found to have less than a third the normal number of OR8A1 expressing olfactory sensory neurons and many were located more ventrally in the epithelium than normal. When crossed to a strain with an IRES-tauGFP marker bicistronically expressed with OR8A1 (see Stock # <a href="https://www.jax.org/strain/006676"">006676</a>) the compound heterozygote did not show co-expression in the same olfactory sensory neurons so the disruption of the promoter in this allele does not interfere with monoallelic expression.

This allele is useful in studying regulatory expression of olfactory receptor family 8 subfamily A member 1. There are five nucleotide substitutions in the promoter that alter both the homeodomain and the O/E-like binding site. Additionally there is a downstream IRES-tauLacZ cassette that is bicistronically expressed.

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