This allele of <em>Or8a1</em> (formerly <em>Olfr151</em>) has five nucleotide substitutions in the promoter that alter both the homeodomain and the O/E-like binding site. Additionally there is a downstream IRES-tauLacZ cassette that is bicistronically expresssed. At 26 days of age homozygotes were found to have less than a third the normal number of OR8A1 expressing olfactory sensory neurons and many were located more ventrally in the epithelium than normal. When crossed to a strain with an IRES-tauGFP marker bicistronically expressed with OR8A1 (see Stock # <a href="https://www.jax.org/strain/006676"">006676</a>) the compound heterozygote did not show co-expression in the same olfactory sensory neurons so the disruption of the promoter in this allele does not interfere with monoallelic expression.

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This allele is useful in studying regulatory expression of olfactory receptor family 8 subfamily A member 1. There are five nucleotide substitutions in the promoter that alter both the homeodomain and the O/E-like binding site. Additionally there is a downstream IRES-tauLacZ cassette that is bicistronically expressed.

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