JAX Mouse Strain Datasheet - 006608

NOD.Cg-Ighm^tm1Cgn Tg(IghelMD4)4Ccg/DvsJ

Stock No:: 006608 |; NOD.IgHEL,Igh-/-

Cryo Recovery

Overview

Also Known As: NOD.IgHEL,Igh-/-, NOD.IgHEL.Igμ^null, NOD.IgHEL.Igu

Mice of this strain do not express endogenous IgM, and all B lymphocytes express Ig molecules specific for hen egg lyzozyme (HEL). This strain may be used to study defects in B-cell selection as it relates to Type 1 Diabetes.

Donating Investigator

Dr. David Serreze, The Jackson Laboratory

Genetic overview

Genetic Background	Generation
001289 NOD/ShiLt

Ighm^tm1Cgn

Allele Type	Gene Symbol	Gene Name
Targeted (Null/Knockout)	Ighm	immunoglobulin heavy constant mu

Tg(IghelMD4)4Ccg

Allele Type
Transgenic (Inserted expressed sequence)

View Genetics

Research Applications

Diabetes and Obesity Research
Immunology, Inflammation and Autoimmunity Research
Research Tools

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Base Price

Starting at:

$2,595.00 Domestic price Cryo Recovery

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Details

Detailed Description

NOD.Cg-Ighm^tm1Cgn Tg(IghelMD4)4Ccg/DvsJ (NOD.IgHEL Ighm-deficient) mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities. Because these mice are Ighm-deficient, they do not express endogenous IgM. All B lymphocytes in NOD.IgHEL Ighm-deficient mice express Ig molecules specific for hen egg lyzozyme (HEL). There is no significant difference in the total number of B and T lymphocytes between NOD.IgHEL Ighm-deficient and NOD.IgHEL (Stock No. 006345) mice. The incidence of diabetes in transgenic vs. non-transgenic NOD.Ighm-deficient mice is similar by 21 weeks of age, (16.7% vs. 13.6%, respectively). Histological evaluation of 12 week old NOD.IgHEL Ighm-deficient mice shows that most mice have low levels of insulitis compared to NOD/ShiLt control mice, although an occasional animal had extensive insulitis. In addition, NOD.IgHEL Ighm-deficient mice develop lymphosarcomas after 20 weeks of age. This pathology is not observed in either NOD.Ighm-deficient or NOD.IgHEL transgenic mice.

This strain may be used to study defects in B-cell selection as it relates to Type 1 Diabetes.

Development

NOD.129S2-Ighm^tm1Cgn/Dvs (Stock No. 003903) at generation N10 was bred with NOD.B6-Tg(IghelMD4)4Ccg/Dvs (Stock No. 004253). The doubly heterozygous offspring were backcrossed to the former strain (Stock No. 003903) to make the strain homozygous for the Ighm^tm1Cgn mutation. Siblings were then intercrossed to make this strain additionally homozygous for Tg(IghelMD4)4Ccg. In 2006, The T1DR received this strain at generation N11F16.

Expression Data

Expressed Gene	Ighg, Immunoglobulin heavy chain (gamma polypeptide), mouse, laboratory
Site of Expression

Control Suggestions

Additional Information

Considerations for Choosing Controls

Selected References

Silveira PA; Johnson E; Chapman HD; Bui T; Tisch RM; Serreze DV. 2002. The preferential ability of B lymphocytes to act as diabetogenic APC in NOD mice depends on expression of self-antigen-specific immunoglobulin receptors.. In: . . MGI: J:80859

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Genetics

Ighm^tm1Cgn

Allele Symbol: Ighm^tm1Cgn

Allele Name	targeted mutation 1, University of Cologne
Allele Type	Targeted (Null/Knockout)
Allele Synonym(s)	B cell^-; BCKO; BCR-; BKO; Cmu ^-; Ig- muMT; Ig^-; IgH-; IgH^muMT; Igh-6-; Igh-6^null; Igh-6^tm1Cgn; Igh-6tm1CgnmuMT⁰; Ighm^-; Igmu^null; mu-MT^-; muIgKO; muMT; muMt-; mum^-
Gene Symbol and Name	Ighm, immunoglobulin heavy constant mu
Gene Synonym(s)	AI326478; BCR; Ig mu; IgM; Igh-6; Igh-M; Igh-M; Igh6; expressed sequence AI326478; immunoglobulin heavy chain 6 (heavy chain of IgM); immunoglobulin heavy chain mu; muH; muMT
Strain of Origin	129S2/SvPas
Chromosome	12
Molecular Note	A neomycin resistance cassette disrupted one of the membrane exons of the gene encoding immunoglobulin heavy chain of the class mu (IgM).
Mutations Made By	Daisuke Kitamura, University of Cologne

Tg(IghelMD4)4Ccg

Allele Symbol: Tg(IghelMD4)4Ccg

Allele Name	transgene insertion 4, Christopher C Goodnow
Allele Type	Transgenic (Inserted expressed sequence)
Allele Synonym(s)	HELmuMT; Hel-Ig; Ig-transgenic; Ig^HEL; Ig^Tg; MD-3; MD4; MD4 HEL Ig; MD4 Ig; MD4 Ig BCR Tg; MD4-RAG; SWHEL
Gene Symbol and Name	Tg(IghelMD4)4Ccg, transgene insertion 4, Christopher C Goodnow
Gene Synonym(s)	HELmuMT; Hel-Ig; Ig-transgenic; Ig^HEL; MD-3; MD4; MD4 HEL Ig; MD4 Ig; MD4 Ig BCR Tg; MD4-RAG
Promoter	Ighg, Immunoglobulin heavy chain (gamma polypeptide), mouse, laboratory
Expressed Gene	Ighg, Immunoglobulin heavy chain (gamma polypeptide), mouse, laboratory
Strain of Origin	C57BL/6
Chromosome	17
Molecular Note	The hybridoma HyHEL10 produces an antibody with high affinity for hen egg lysozyme. Genomic clones encoding HyHEL10 immunoglobulin heavy and light chains were used for this construct. The gamma1-constant region of the heavy chain was replaced by a segment containing the mu and delta constant region genes derived from BALB/c mice. The light and heavy chains were co-injected into C57BL/6 eggs. Five lines, MD3-MD7, that carried multiple copies of the transgene construct were created. The MD4 line had the highest expression of the transgene and was propogated for further studies. Mice carrying this transgene had high serum titers of anti-lysozyme antibodies.
Mutations Made By	Dr. Christopher Goodnow, Stanford University School of Medicine

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Diabetes and Obesity Research
- Type 1 Diabetes (IDDM) Analysis Strains
  - NOD Transgenics
Immunology, Inflammation and Autoimmunity Research
- Autoimmunity
  - Type 1 Diabetes
- Immunodeficiency
  - B cell defects

Genotype: Ighm^tm1Cgn related

Immunology, Inflammation and Autoimmunity Research
- Immunodeficiency
  - B cell deficiency
Research Tools
- Cancer Research
  - B cell deficiency
- Immunology, Inflammation and Autoimmunity Research
  - B cell deficiency

Mammalian Phenotype Terms by Genotype

Genotype: Ighm^tm1Cgn/Ighm^tm1Cgn Tg(IghelMD4)4Ccg/Tg(IghelMD4)4Ccg
NOD.Cg-Ighm^tm1Cgn Tg(IghelMD4)4Ccg/DvsJ

immune system phenotype

abnormal B lymphocyte antigen presentation
- purified B cells fail to stimulate T cells from non-transgenic NOD mice when cultured together in the presence of the diabetes autoantigen GAD

abnormal T cell proliferation
- T cells fail to proliferate when splenocytes are cultured in vitro with the diabetes autoantigen GAD

abnormal mature B cell morphology
- all of the B cells express the transgenic IgM B cell receptor specific for hen egg lysozyme
- the number but not the proportion of B cells found in the spleen is twice that of non-transgenic NOD mice

decreased CD8-positive, alpha-beta T cell number
- the number of CD8 T cells found in the spleen is half that of non-transgenic NOD mice

decreased susceptibility to autoimmune diabetes
- 16.7% of female mice develop diabetes by 21 weeks of age compared to control NOD mice that have an incidence rate of 95.5% at this age
- mice with lymphosarcomas were not included in the analysis

insulitis
- mice have low levels of insulitis starting at 12 weeks of age with a mean disease score of 1.62 compared to non-transgenic NOD mice that have a mean score of 3.01 at this age

neoplasm

increased lymphoma incidence
- lymphosarcomas are present in the majority of mice with development starting at 20 weeks of age

hematopoietic system phenotype

abnormal B lymphocyte antigen presentation
- purified B cells fail to stimulate T cells from non-transgenic NOD mice when cultured together in the presence of the diabetes autoantigen GAD

abnormal T cell proliferation
- T cells fail to proliferate when splenocytes are cultured in vitro with the diabetes autoantigen GAD

abnormal mature B cell morphology
- all of the B cells express the transgenic IgM B cell receptor specific for hen egg lysozyme
- the number but not the proportion of B cells found in the spleen is twice that of non-transgenic NOD mice

decreased CD8-positive, alpha-beta T cell number
- the number of CD8 T cells found in the spleen is half that of non-transgenic NOD mice

endocrine/exocrine gland phenotype

insulitis
- mice have low levels of insulitis starting at 12 weeks of age with a mean disease score of 1.62 compared to non-transgenic NOD mice that have a mean score of 3.01 at this age

References

Silveira PA; Johnson E; Chapman HD; Bui T; Tisch RM; Serreze DV. 2002. The preferential ability of B lymphocytes to act as diabetogenic APC in NOD mice depends on expression of self-antigen-specific immunoglobulin receptors.. In: . . MGI: J:80859

Additional - Ighm^tm1Cgn related

Abraham D; Leon O; Schnyder-Candrian S; Wang CC; Galioto AM; Kerepesi LA; Lee JJ; Lustigman S. 2004. Immunoglobulin E and eosinophil-dependent protective immunity to larval Onchocerca volvulus in mice immunized with irradiated larvae.. In: . . MGI: J:87861
Akashi T; Nagafuchi S; Anzai K; Kitamura D; Wang J; Taniuchi I; Niho Y; Watanabe T. 1998. Proliferation of CD3+ B220- single-positive normal T cells was suppressed in B-cell-deficient lpr mice.. In: . . MGI: J:45808
Ali M; Weinreich M; Balcaitis S; Cooper CJ; Fink PJ. 2003. Differential regulation of peripheral CD4+ T cell tolerance induced by deletion and TCR revision.. In: . . MGI: J:132828
Allen HL; Deepe GS Jr. 2006. B cells and CD4-CD8- T cells are key regulators of the severity of reactivation histoplasmosis.. In: . . MGI: J:138028
Alpan O; Rudomen G; Matzinger P. 2001. The role of dendritic cells, B cells, and M cells in gut-oriented immune responses.. In: . . MGI: J:68620
Amante FH; Haque A; Stanley AC; Rivera Fde L; Randall LM; Wilson YA; Yeo G; Pieper C; Crabb BS; de Koning-Ward TF; Lundie RJ; Good MF; Pinzon-Charry A; Pearson MS; Duke MG; McManus DP; Loukas A; Hill GR; Engwerda CR. 2010. Immune-Mediated Mechanisms of Parasite Tissue Sequestration during Experimental Cerebral Malaria.. In: . . MGI: J:163540
Andersen C; Jensen T; Nansen A; Marker O; Thomsen AR. 1999. CD4(+) T cell-mediated protection against a lethal outcome of systemic infection with vesicular stomatitis virus requires CD40 ligand expression, but not IFN-gamma or IL-4.. In: . . MGI: J:110491
Ando T; Matsumoto K; Namiranian S; Yamashita H; Glatthorn H; Kimura M; Dolan BR; Lee JJ; Galli SJ; Kawakami Y; Jamora C; Kawakami T. 2013. Mast Cells Are Required for Full Expression of Allergen/SEB-Induced Skin Inflammation.. In: . . MGI: J:202870
Andoh M; Zhang G; Russell-Lodrigue KE; Shive HR; Weeks BR; Samuel JE. 2007. T Cells Are Essential for Bacterial Clearance, and Gamma Interferon, Tumor Necrosis Factor Alpha, and B Cells Are Crucial for Disease Development in Coxiella burnetii Infection in Mice.. In: . . MGI: J:122426
Andreansky S; Liu H; Adler H; Koszinowski UH; Efstathiou S; Doherty PC. 2004. The limits of protection by 'memory' T cells in Ig-/- mice persistently infected with a gamma-herpesvirus.. In: . . MGI: J:88442
Andrews DM; Smyth MJ. 2010. A potential role for RAG-1 in NK cell development revealed by analysis of NK cells during ontogeny.. In: . . MGI: J:163794
Angeli V; Ginhoux F; Llodra J; Quemeneur L; Frenette PS; Skobe M; Jessberger R; Merad M; Randolph GJ. 2006. B cell-driven lymphangiogenesis in inflamed lymph nodes enhances dendritic cell mobilization.. In: . . MGI: J:113320
Ankeny DP; Guan Z; Popovich PG. 2009. B cells produce pathogenic antibodies and impair recovery after spinal cord injury in mice.. In: . . MGI: J:154634
Archer NK; Harro JM; Shirtliff ME. 2013. Clearance of Staphylococcus aureus nasal carriage is T cell dependent and mediated through interleukin-17A expression and neutrophil influx.. In: . . MGI: J:199531
Aroeira LS; Mouton CG; Toran JL; Ward ES; Martinez C. 1999. Anti-Vbeta8 antibodies induce and maintain staphylococcal enterotoxin B-triggered Vbeta8+ T cell anergy.. In: . . MGI: J:115226
Arras M; Louahed J; Heilier JF; Delos M; Brombacher F; Renauld JC; Lison D; Huaux F. 2005. IL-9 protects against bleomycin-induced lung injury: involvement of prostaglandins.. In: . . MGI: J:95244
Arras M; Louahed J; Simoen V; Barbarin V; Misson P; van den Brule S; Delos M; Knoops L; Renauld JC; Lison D; Huaux F. 2006. B lymphocytes are critical for lung fibrosis control and prostaglandin E2 regulation in IL-9 transgenic mice.. In: . . MGI: J:136512
Asano MS; Ahmed R. 1996. CD8 T cell memory in B cell-deficient mice.. In: . . MGI: J:33136
Ashbaugh JJ; Brambilla R; Karmally SA; Cabello C; Malek TR; Bethea JR. 2013. IL7Ralpha Contributes to Experimental Autoimmune Encephalomyelitis through Altered T Cell Responses and Nonhematopoietic Cell Lineages.. In: . . MGI: J:195519
Ashour HM; Niederkorn JY. 2006. Peripheral tolerance via the anterior chamber of the eye: role of B cells in MHC class I and II antigen presentation.. In: . . MGI: J:131707
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Bajenoff M; Germain RN. 2009. B-cell follicle development remodels the conduit system and allows soluble antigen delivery to follicular dendritic cells.. In: . . MGI: J:155014
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Barr TA; Brown S; Mastroeni P; Gray D. 2010. TLR and B cell receptor signals to B cells differentially program primary and memory Th1 responses to Salmonella enterica.. In: . . MGI: J:163256
Barr TA; Brown S; Mastroeni P; Gray D. 2009. B cell intrinsic MyD88 signals drive IFN-gamma production from T cells and control switching to IgG2c.. In: . . MGI: J:151505
Basu S; Ray A; Dittel BN. 2011. Cannabinoid receptor 2 is critical for the homing and retention of marginal zone B lineage cells and for efficient T-independent immune responses.. In: . . MGI: J:179699
Batten M; Ramamoorthi N; Kljavin NM; Ma CS; Cox JH; Dengler HS; Danilenko DM; Caplazi P; Wong M; Fulcher DA; Cook MC; King C; Tangye SG; de Sauvage FJ; Ghilardi N. 2010. IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells.. In: . . MGI: J:176869
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Belperron AA; Bockenstedt LK. 2001. Natural Antibody Affects Survival of the Spirochete Borrelia burgdorferi within Feeding Ticks.. In: . . MGI: J:71569
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Additional - Tg(IghelMD4)4Ccg related

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Nijnik A; Dawson S; Crockford TL; Woodbine L; Visetnoi S; Bennett S; Jones M; Turner GD; Jeggo PA; Goodnow CC; Cornall RJ. 2009. Impaired lymphocyte development and antibody class switching and increased malignancy in a murine model of DNA ligase IV syndrome.. In: . . MGI: J:150573
O'Neill SK; Getahun A; Gauld SB; Merrell KT; Tamir I; Smith MJ; Dal Porto JM; Li QZ; Cambier JC. 2011. Monophosphorylation of CD79a and CD79b ITAM Motifs Initiates a SHIP-1 Phosphatase-Mediated Inhibitory Signaling Cascade Required for B Cell Anergy.. In: . . MGI: J:178833
Okada T; Miller MJ; Parker I; Krummel MF; Neighbors M; Hartley SB; O'Garra A; Cahalan MD; Cyster JG. 2005. Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells.. In: . . MGI: J:99611
Okuyama K; Murata A; Sudo T; Yoshino M; Hayashi S. 2012. A checkpoint in B-lymphopoiesis related to Notch resistance.. In: . . MGI: J:180314
Patakas A; Benson RA; Withers DR; Conigliaro P; McInnes IB; Brewer JM; Garside P. 2012. Th17 effector cells support B cell responses outside of germinal centres.. In: . . MGI: J:195462
Pathak S; Ma S; Shukla V; Lu R. 2013. A role for IRF8 in B cell anergy.. In: . . MGI: J:207133
Pathak S; Ma S; Trinh L; Lu R. 2008. A role for interferon regulatory factor 4 in receptor editing.. In: . . MGI: J:133924
Patterson HC; Kraus M; Kim YM; Ploegh H; Rajewsky K. 2006. The B cell receptor promotes B cell activation and proliferation through a non-ITAM tyrosine in the Igalpha cytoplasmic domain.. In: . . MGI: J:113407
Pereira JP; Kelly LM; Xu Y; Cyster JG. 2009. EBI2 mediates B cell segregation between the outer and centre follicle.. In: . . MGI: J:151077
Pfrengle F; Macauley MS; Kawasaki N; Paulson JC. 2013. Copresentation of antigen and ligands of Siglec-G induces B cell tolerance independent of CD22.. In: . . MGI: J:205703
Phan TG; Amesbury M; Gardam S; Crosbie J; Hasbold J; Hodgkin PD; Basten A; Brink R. 2003. B cell receptor-independent stimuli trigger immunoglobulin (Ig) class switch recombination and production of IgG autoantibodies by anergic self-reactive B cells.. In: . . MGI: J:132538
Ploquin MJ; Eksmond U; Kassiotis G. 2011. B cells and TCR avidity determine distinct functions of CD4+ T cells in retroviral infection.. In: . . MGI: J:179252
Pluger EB; Boes M; Alfonso C; Schroter CJ; Kalbacher H; Ploegh HL; Driessen C. 2002. Specific role for cathepsin S in the generation of antigenic peptides in vivo.. In: . . MGI: J:107213
Poe JC; Kountikov EI; Lykken JM; Natarajan A; Marchuk DA; Tedder TF. 2014. EndoU is a novel regulator of AICD during peripheral B cell selection.. In: . . MGI: J:208364
Poholek AC; Hansen K; Hernandez SG; Eto D; Chandele A; Weinstein JS; Dong X; Odegard JM; Kaech SM; Dent AL; Crotty S; Craft J. 2010. In vivo regulation of Bcl6 and T follicular helper cell development.. In: . . MGI: J:161433
Prazma CM; Yazawa N; Fujimoto Y; Fujimoto M; Tedder TF. 2007. CD83 expression is a sensitive marker of activation required for B cell and CD4+ T cell longevity in vivo.. In: . . MGI: J:152350
Qi H; Cannons JL; Klauschen F; Schwartzberg PL; Germain RN. 2008. SAP-controlled T-B cell interactions underlie germinal centre formation.. In: . . MGI: J:140086
Quah BJ; Barlow VP; McPhun V; Matthaei KI; Hulett MD; Parish CR. 2008. Bystander B cells rapidly acquire antigen receptors from activated B cells by membrane transfer.. In: . . MGI: J:173514
Quong MW; Harris DP; Swain SL; Murre C. 1999. E2A activity is induced during B-cell activation to promote immunoglobulin class switch recombination.. In: . . MGI: J:118965
Refaeli Y; Young RM; Turner BC; Duda J; Field KA; Bishop JM. 2008. The B cell antigen receptor and overexpression of MYC can cooperate in the genesis of B cell lymphomas.. In: . . MGI: J:139351
Reif K; Okkenhaug K; Sasaki T; Penninger JM; Vanhaesebroeck B; Cyster JG. 2004. Cutting edge: differential roles for phosphoinositide 3-kinases, p110gamma and p110delta, in lymphocyte chemotaxis and homing.. In: . . MGI: J:92733
Rivera A; Chen CC; Ron N; Dougherty JP; Ron Y. 2001. Role of B cells as antigen-presenting cells in vivo revisited: antigen-specific B cells are essential for T cell expansion in lymph nodes and for systemic T cell responses to low antigen concentrations.. In: . . MGI: J:107395
Roldan E; Fuxa M; Chong W; Martinez D; Novatchkova M; Busslinger M; Skok JA. 2005. Locus 'decontraction' and centromeric recruitment contribute to allelic exclusion of the immunoglobulin heavy-chain gene.. In: . . MGI: J:134531
Roy V; Bonventi G; Cai Y; Macleod R; Wither JE. 2007. Immune mechanisms leading to abnormal B cell selection and activation in New Zealand Black mice.. In: . . MGI: J:124351
Roy V; Chang NH; Cai Y; Bonventi G; Wither J. 2005. Aberrant IgM signaling promotes survival of transitional T1 B cells and prevents tolerance induction in lupus-prone New Zealand black mice.. In: . . MGI: J:122135
Rubtsova K; Rubtsov AV; van Dyk LF; Kappler JW; Marrack P. 2013. T-box transcription factor T-bet, a key player in a unique type of B-cell activation essential for effective viral clearance.. In: . . MGI: J:200754
Sabouri Z; Perotti S; Spierings E; Humburg P; Yabas M; Bergmann H; Horikawa K; Roots C; Lambe S; Young C; Andrews TD; Field M; Enders A; Reed JH; Goodnow CC. 2016. IgD attenuates the IgM-induced anergy response in transitional and mature B cells.. In: . . MGI: J:242719
Saez de Guinoa J; Barrio L; Mellado M; Carrasco YR. 2011. CXCL13/CXCR5 signaling enhances BCR-triggered B-cell activation by shaping cell dynamics.. In: . . MGI: J:176933
Schram BR; Tze LE; Ramsey LB; Liu J; Najera L; Vegoe AL; Hardy RR; Hippen KL; Farrar MA; Behrens TW. 2008. B cell receptor Basal signaling regulates antigen-induced Ig light chain rearrangements.. In: . . MGI: J:133383
Sharbeen G; Yee CW; Smith AL; Jolly CJ. 2012. Ectopic restriction of DNA repair reveals that UNG2 excises AID-induced uracils predominantly or exclusively during G1 phase.. In: . . MGI: J:185140
Shimomura Y; Ogawa A; Kawada M; Sugimoto K; Mizoguchi E; Shi HN; Pillai S; Bhan AK; Mizoguchi A. 2008. A unique B2 B cell subset in the intestine.. In: . . MGI: J:137039
Siggs OM; Stockenhuber A; Deobagkar-Lele M; Bull KR; Crockford TL; Kingston BL; Crawford G; Anzilotti C; Steeples V; Ghaffari S; Czibik G; Bellahcene M; Watkins H; Ashrafian H; Davies B; Woods A; Carling D; Yavari A; Beutler B; Cornall RJ. 2016. Mutation of Fnip1 is associated with B-cell deficiency, cardiomyopathy, and elevated AMPK activity.. In: . . MGI: J:234285
Silva DG; Daley SR; Hogan J; Lee SK; Teh CE; Hu DY; Lam KP; Goodnow CC; Vinuesa CG. 2011. Anti-islet autoantibodies trigger autoimmune diabetes in the presence of an increased frequency of islet-reactive CD4 T cells.. In: . . MGI: J:186792
Silveira PA; Chapman HD; Stolp J; Johnson E; Cox SL; Hunter K; Wicker LS; Serreze DV. 2006. Genes within the Idd5 and Idd9/11 Diabetes Susceptibility Loci Affect the Pathogenic Activity of B Cells in Nonobese Diabetic Mice.. In: . . MGI: J:114754
Silveira PA; Dombrowsky J; Johnson E; Chapman HD; Nemazee D; Serreze DV. 2004. B cell selection defects underlie the development of diabetogenic APCs in nonobese diabetic mice.. In: . . MGI: J:89156
Silver K; Ferry H; Crockford T; Cornall RJ. 2006. TLR4, TLR9 and MyD88 are not required for the positive selection of autoreactive B cells into the primary repertoire.. In: . . MGI: J:115059
Skelsey ME; Mayhew E; Niederkorn JY. 2003. Splenic B cells act as antigen presenting cells for the induction of anterior chamber-associated immune deviation.. In: . . MGI: J:107362
Stolp J; Marino E; Batten M; Sierro F; Cox SL; Grey ST; Silveira PA. 2013. Intrinsic molecular factors cause aberrant expansion of the splenic marginal zone B cell population in nonobese diabetic mice.. In: . . MGI: J:205458
Straub T; Schweier O; Bruns M; Nimmerjahn F; Waisman A; Pircher H. 2013. Nucleoprotein-specific nonneutralizing antibodies speed up LCMV elimination independently of complement and FcgammaR.. In: . . MGI: J:201330
Su YW; Chen YP; Chen MY; Reth M; Tan TH. 2013. The serine/threonine phosphatase PP4 is required for pro-B cell development through its promotion of immunoglobulin VDJ recombination.. In: . . MGI: J:204399
Swanson-Mungerson M; Bultema R; Longnecker R. 2006. Epstein-Barr virus LMP2A enhances B-cell responses in vivo and in vitro.. In: . . MGI: J:147405
Taylor JJ; Martinez RJ; Titcombe PJ; Barsness LO; Thomas SR; Zhang N; Katzman SD; Jenkins MK; Mueller DL. 2012. Deletion and anergy of polyclonal B cells specific for ubiquitous membrane-bound self-antigen.. In: . . MGI: J:190897
Tsitoura DC; Yeung VP; DeKruyff RH; Umetsu DT. 2002. Critical role of B cells in the development of T cell tolerance to aeroallergens.. In: . . MGI: J:133557
Tze LE; Schram BR; Lam KP; Hogquist KA; Hippen KL; Liu J; Shinton SA; Otipoby KL; Rodine PR; Vegoe AL; Kraus M; Hardy RR; Schlissel MS; Rajewsky K; Behrens TW. 2005. Basal immunoglobulin signaling actively maintains developmental stage in immature B cells.. In: . . MGI: J:133822
Ubelhart R; Hug E; Bach MP; Wossning T; Duhren-von Minden M; Horn AH; Tsiantoulas D; Kometani K; Kurosaki T; Binder CJ; Sticht H; Nitschke L; Reth M; Jumaa H. 2015. Responsiveness of B cells is regulated by the hinge region of IgD.. In: . . MGI: J:231857
Velazquez P; Wei B; McPherson M; Mendoza LM; Nguyen SL; Turovskaya O; Kronenberg M; Huang TT; Schrage M; Lobato LN; Fujiwara D; Brewer S; Arditi M; Cheng G; Sartor RB; Newberry RD; Braun J. 2008. Villous B cells of the small intestine are specialized for invariant NK T cell dependence.. In: . . MGI: J:133099
Villa M; Gialitakis M; Tolaini M; Ahlfors H; Henderson CJ; Wolf CR; Brink R; Stockinger B. 2017. Aryl hydrocarbon receptor is required for optimal B-cell proliferation.. In: . . MGI: J:239088
Wang JQ; Jeelall YS; Beutler B; Horikawa K; Goodnow CC. 2014. Consequences of the recurrent MYD88(L265P) somatic mutation for B cell tolerance.. In: . . MGI: J:210476
Weber M; Treanor B; Depoil D; Shinohara H; Harwood NE; Hikida M; Kurosaki T; Batista FD. 2008. Phospholipase C-gamma2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigen.. In: . . MGI: J:133999
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Also Known As: NOD.IgHEL,Igh-/-, NOD.IgHEL.Igμnull, NOD.IgHEL.Igu

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Ighmtm1Cgn

Allele Symbol: Ighmtm1Cgn

Tg(IghelMD4)4Ccg

Allele Symbol: Tg(IghelMD4)4Ccg

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This mouse can be used to support research in many areas including:

Genotype: Ighmtm1Cgn related

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Genotype: Ighmtm1Cgn/Ighmtm1Cgn Tg(IghelMD4)4Ccg/Tg(IghelMD4)4CcgNOD.Cg-Ighmtm1Cgn Tg(IghelMD4)4Ccg/DvsJ

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endocrine/exocrine gland phenotype

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Additional - Ighmtm1Cgn related

Additional - Tg(IghelMD4)4Ccg related

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Also Known As: NOD.IgHEL,Igh-/-, NOD.IgHEL.Igμ^null, NOD.IgHEL.Igu

Ighm^tm1Cgn

Allele Symbol: Ighm^tm1Cgn

Genotype: Ighm^tm1Cgn related

Genotype: Ighm^tm1Cgn/Ighm^tm1Cgn Tg(IghelMD4)4Ccg/Tg(IghelMD4)4Ccg
NOD.Cg-Ighm^tm1Cgn Tg(IghelMD4)4Ccg/DvsJ

Additional - Ighm^tm1Cgn related