JAX Mouse Strain Datasheet - 006605

NOD.Cg-Prkdc^scid Emv30^b Tg(HLA-A/H2-D/B2M)1Dvs/DvsJ

Stock No:: 006605 |; NOD.scid HHD

Cryo Recovery

Overview

Also Known As: NOD.scid HHD

These multiple mutant mice express the human histocompatibility complex (MHC) class I HLA-A2.1 allele in the absence of mouse H-2D^b, Β2m, and endogenous ecotropic murine leukemia virus (Emv30^b).

Donating Investigator

Dr. David Serreze, The Jackson Laboratory

Genetic overview

Genetic Background	Generation
002313 NOD.Cg-Prkdc^scid Emv30^b/Dvs

Emv30^b

Allele Type	Gene Symbol	Gene Name
Not Applicable	Emv30	endogenous ecotropic MuLV 30

Prkdc^scid

Allele Type	Gene Symbol	Gene Name
Spontaneous	Prkdc	protein kinase, DNA activated, catalytic polypeptide

Tg(HLA-A/H2-D/B2M)1Dvs

Allele Type
Transgenic (Humanized sequence, Inserted expressed sequence)

View Genetics

Research Applications

Diabetes and Obesity Research
Immunology, Inflammation and Autoimmunity Research
Research Tools
Internal/Organ Research
Virology Research

View All Research Applications

Base Price

Starting at:

$2,595.00 Domestic price Cryo Recovery

View Price List

Details

Detailed Description

Although NOD mice that carry this transgene (Stock No. 006604) develop diabetes significantly earlier than do NOD/ShiLtDvs (NOD) controls, this transgenic strain harbors the Prkdc^scid mutation (characterized by an absence of functional T cells and B cells), and therefore does not become diabetic. This strain is useful for adoptive transfer experiments, and as a source of insulitis free pancreatic islets.

Development

This transgene encodes a human B2-microglubulin (B2M) covalently linked to the MHC class 1, alpha1 and alpha2 binding domains of the human HLA-A2.1 gene and the alpha3, cytoplasmic and transmembrane domains of the murine H2-D^b protein. The transgene was injected into NOD/ShiLtDvs embryos. Transgenic offspring were mated to NOD.Prkdc^scid Emv30^b (Stock No. 002313), prior to sibling mating and fixing for homozygosity. In 2007, the T1DR received this stock at generation N2F2.

Expression Data

Expressed Gene	B2M, beta-2-microglobulin, human
Expressed Gene	HLA-A, major histocompatibility complex, class I, A, human
Site of Expression

Control Suggestions

Additional Information

Considerations for Choosing Controls

Selected References

Pascolo S; Bervas N; Ure JM; Smith AG; Lemonnier FA; Perarnau B. 1997. HLA-A2.1-restricted education and cytolytic activity of CD8(+) T lymphocytes from beta2 microglobulin (beta2m) HLA-A2.1 monochain transgenic H-2Db beta2m double knockout mice.. In: . . MGI: J:41077
Takaki T; Marron MP; Mathews CE; Guttmann ST; Bottino R; Trucco M; DiLorenzo TP; Serreze DV. 2006. HLA-A*0201-restricted T cells from humanized NOD mice recognize autoantigens of potential clinical relevance to type 1 diabetes.. In: . . MGI: J:121685

View All References

Genetics

Emv30^b

Allele Symbol: Emv30^b

Allele Name	endogenous ecotropic murine leukemia virus, absent
Allele Type	Not Applicable
Allele Synonym(s)
Gene Symbol and Name	Emv30, endogenous ecotropic MuLV 30
Gene Synonym(s)	Emv-30; Emv-30
Strain of Origin	Not Applicable
Chromosome	11
General Note	The provirus is missing from C57BLKS/J and from the NOR/LtDn stock which was derived from an NOD subline genetically contaminated with C57BLKS/J (J:14300, J:29951).

Prkdc^scid

Allele Symbol: Prkdc^scid

Allele Name	severe combined immunodeficiency
Allele Type	Spontaneous
Allele Synonym(s)	SCID; scid
Gene Symbol and Name	Prkdc, protein kinase, DNA activated, catalytic polypeptide
Gene Synonym(s)	AI326420; AU019811; DNA-PK; DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH; HYRC; HYRC1; IMD26; XRCC7; doxorubicin nephropathy; dxnph; dxnph; expressed sequence AI326420; expressed sequence AU019811; p350; scid; severe combined immunodeficiency; slip
Site of Expression	T and B lymphocytes.
Strain of Origin	C.B-17
Chromosome	16
Molecular Note	A T-to-A transversion point mutation at a position corresponding to codon 4095 created a premature stop codon.

Tg(HLA-A/H2-D/B2M)1Dvs

Allele Symbol: Tg(HLA-A/H2-D/B2M)1Dvs

Allele Name	transgene insertion 1, David Serreze
Allele Type	Transgenic (Humanized sequence, Inserted expressed sequence)
Allele Synonym(s)	HDD; HHD
Gene Symbol and Name	Tg(HLA-A/H2-D/B2M)1Dvs, transgene insertion 1, David Serreze
Gene Synonym(s)	HDD; HHD
Promoter	HLA-A2.1, major histocompatibility complex, class I, subtype A2.1, human
Expressed Gene	B2M, beta-2-microglobulin, human
Expressed Gene	HLA-A, major histocompatibility complex, class I, A, human
Strain of Origin	NOD/ShiLtDvs
Chromosome	UN
General Note	The HDD construct was created and used to generate a differnet transgenic mouse line in J:41077.
Molecular Note	This transgene encodes a human B2-microglubulin (B2M) covalently linked to the MHC class 1, alpha1 and alpha2 binding domains of the human HLA-A2.1 gene, and the alpha3, cytoplasmic and transmembrane domains of the murine H2-D^b. The construct was injected into fertilized NOD/ShiLtDvs oocytes. The construct was originally described in J:41077 and used to create a different transgenic line.
Mutations Made By	Dr. David Serreze, The Jackson Laboratory

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Diabetes and Obesity Research
- Islet Transplantation Studies
- Type 1 Diabetes (IDDM) Analysis Strains
  - NOD Congenics with Mutations Affecting Immunocompetence
  - NOD Transgenics
Immunology, Inflammation and Autoimmunity Research
- HLA transgenics
Research Tools
- Immunology, Inflammation and Autoimmunity Research
  - T cell deficiency, xenograft/transplant host

Genotype: Prkdc^scid related

Immunology, Inflammation and Autoimmunity Research
- Immunodeficiency
  - B and T cell deficiency
Internal/Organ Research
- Lymphoid Tissue Defects
  - B and T cell deficiency
Research Tools
- Cancer Research
  - B and T cell deficiency, xenograft/transplant host
- Toxicology Research
  - xenograft/transplant host
Virology Research
- B and T Cell Deficiency
  - AIDS research tool

References

Pascolo S; Bervas N; Ure JM; Smith AG; Lemonnier FA; Perarnau B. 1997. HLA-A2.1-restricted education and cytolytic activity of CD8(+) T lymphocytes from beta2 microglobulin (beta2m) HLA-A2.1 monochain transgenic H-2Db beta2m double knockout mice.. In: . . MGI: J:41077
Takaki T; Marron MP; Mathews CE; Guttmann ST; Bottino R; Trucco M; DiLorenzo TP; Serreze DV. 2006. HLA-A*0201-restricted T cells from humanized NOD mice recognize autoantigens of potential clinical relevance to type 1 diabetes.. In: . . MGI: J:121685

Additional References

Taylor BA; Rowe L; Grieco DA. 1993. The MEV mouse linkage testing stock: mapping 30 novel proviral insertions and establishment of an improved stock.. In: . . MGI: J:4958

Additional - Emv30^b related

Marron MP; Graser RT; Chapman HD; Serreze DV. 2002. Functional evidence for the mediation of diabetogenic T cell responses by HLA-A2.1 MHC class I molecules through transgenic expression in NOD mice.. In: . . MGI: J:109851
Prochazka M; Gaskins HR; Leiter EH. 1991. Emv-30: a novel ecotropic MuLV present in NOD/Lt and NON/Lt strains.. In: . . MGI: J:14300
Serreze DV; Leiter EH; Hanson MS; Christianson SW; Shultz LD; Hesselton RM; Greiner DL. 1995. Emv30null NOD-scid mice. An improved host for adoptive transfer of autoimmune diabetes and growth of human lymphohematopoietic cells.. In: . . MGI: J:29951

Additional - Prkdc^scid related

Accardi R; Gruffat H; Sirand C; Fusil F; Gheit T; Hernandez-Vargas H; Le Calvez-Kelm F; Traverse-Glehen A; Cosset FL; Manet E; Wild CP; Tommasino M. 2015. The mycotoxin aflatoxin B1 stimulates Epstein-Barr virus-induced B-cell transformation in in vitro and in vivo experimental models.. In: . . MGI: J:226625
Agerstam H; Jaras M; Andersson A; Johnels P; Hansen N; Lassen C; Rissler M; Gisselsson D; Olofsson T; Richter J; Fan X; Ehinger M; Fioretos T. 2010. Modeling the human 8p11-myeloproliferative syndrome in immunodeficient mice.. In: . . MGI: J:164507
Agliano A; Martin-Padura I; Mancuso P; Marighetti P; Rabascio C; Pruneri G; Shultz LD; Bertolini F. 2008. Human acute leukemia cells injected in NOD/LtSz-scid/IL-2Rgamma null mice generate a faster and more efficient disease compared to other NOD/scid-related strains.. In: . . MGI: J:142410
Ahsmann EJ; van Tol MJ; Oudeman-Gruber J; Lokhorst H; Uytdehaag FG; Schuurman HJ; Bloem AC. 1995. The SCID mouse as a model for multiple myeloma.. In: . . MGI: J:22989
Akiba H; Takeda K; Kojima Y; Usui Y; Harada N; Yamazaki T; Ma J; Tezuka K; Yagita H; Okumura K. 2005. The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivo.. In: . . MGI: J:107507
Al-Qaoud KM; Fleischer B; Hoerauf A. 1998. The Xid defect imparts susceptibility to experimental murine filariosis--association with a lack of antibody and IL-10 production by B cells in response to phosphorylcholine.. In: . . MGI: J:110480
Alba A; Puertas MC; Carrillo J; Planas R; Ampudia R; Pastor X; Bosch F; Pujol-Borrell R; Verdaguer J; Vives-Pi M. 2004. IFNbeta accelerates autoimmune type 1 diabetes in nonobese diabetic mice and breaks the tolerance to beta cells in nondiabetes-prone mice.. In: . . MGI: J:94366
Alfaro MP; Pagni M; Vincent A; Atkinson J; Hill MF; Cates J; Davidson JM; Rottman J; Lee E; Young PP. 2008. The Wnt modulator sFRP2 enhances mesenchymal stem cell engraftment, granulation tissue formation and myocardial repair.. In: . . MGI: J:142215
Ali N; Flutter B; Sanchez Rodriguez R; Sharif-Paghaleh E; Barber LD; Lombardi G; Nestle FO. 2012. Xenogeneic graft-versus-host-disease in NOD-scid IL-2Rgammanull mice display a T-effector memory phenotype.. In: . . MGI: J:191672
Alugupalli KR; Gerstein RM; Chen J; Szomolanyi-Tsuda E; Woodland RT; Leong JM. 2003. The resolution of relapsing fever borreliosis requires IgM and is concurrent with expansion of B1b lymphocytes.. In: . . MGI: J:125443
Amarnath S; Foley JE; Farthing DE; Gress RE; Laurence A; Eckhaus MA; Metais JY; Rose JJ; Hakim FT; Felizardo TC; Cheng AV; Robey PG; Stroncek DE; Sabatino M; Battiwalla M; Ito S; Fowler DH; Barrett AJ. 2015. Bone marrow-derived mesenchymal stromal cells harness purinergenic signaling to tolerize human Th1 cells in vivo.. In: . . MGI: J:224046
Ambrosino E; Spadaro M; Iezzi M; Curcio C; Forni G; Musiani P; Wei WZ; Cavallo F. 2006. Immunosurveillance of Erbb2 carcinogenesis in transgenic mice is concealed by a dominant regulatory T-cell self-tolerance.. In: . . MGI: J:112102
Amezcua Vesely MC; Schwartz M; Bermejo DA; Montes CL; Cautivo KM; Kalergis AM; Rawlings DJ; Acosta-Rodriguez EV; Gruppi A. 2012. FcgammaRIIb and BAFF differentially regulate peritoneal B1 cell survival.. In: . . MGI: J:188666
Amrani A; Verdaguer J; Anderson B; Utsugi T; Bou S; Santamaria P. 1999. Perforin-independent beta-cell destruction by diabetogenic CD8(+) T lymphocytes in transgenic nonobese diabetic mice.. In: . . MGI: J:108737
Anders K; Buschow C; Herrmann A; Milojkovic A; Loddenkemper C; Kammertoens T; Daniel P; Yu H; Charo J; Blankenstein T. 2011. Oncogene-Targeting T Cells Reject Large Tumors while Oncogene Inactivation Selects Escape Variants in Mouse Models of Cancer.. In: . . MGI: J:178597
Anderson MG; Nair KS; Amonoo LA; Mehalow A; Trantow CM; Masli S; John SW. 2008. GpnmbR150X allele must be present in bone marrow derived cells to mediate DBA/2J glaucoma.. In: . . MGI: J:134670
Andoh M; Zhang G; Russell-Lodrigue KE; Shive HR; Weeks BR; Samuel JE. 2007. T Cells Are Essential for Bacterial Clearance, and Gamma Interferon, Tumor Necrosis Factor Alpha, and B Cells Are Crucial for Disease Development in Coxiella burnetii Infection in Mice.. In: . . MGI: J:122426
Andre MC; Erbacher A; Gille C; Schmauke V; Goecke B; Hohberger A; Mang P; Wilhelm A; Mueller I; Herr W; Lang P; Handgretinger R; Hartwig UF. 2010. Long-term human CD34(+) stem cell-engrafted nonobese diabetic/SCID/IL-2Rgamma(null) mice show impaired CD8(+) T cell maintenance and a functional arrest of immature NK cells.. In: . . MGI: J:163262
Araki R; Fujimori A; Hamatani K; Mita K; Saito T; Mori M; Fukumura R; Morimyo M; Muto M; Itoh M; Tatsumi K; Abe M. 1997. Nonsense mutation at Tyr-4046 in the DNA-dependent protein kinase catalytic subunit of severe combined immune deficiency mice.. In: . . MGI: J:39329
Archer NK; Harro JM; Shirtliff ME. 2013. Clearance of Staphylococcus aureus nasal carriage is T cell dependent and mediated through interleukin-17A expression and neutrophil influx.. In: . . MGI: J:199531
Arendt LM; McCready J; Keller PJ; Baker DD; Naber SP; Seewaldt V; Kuperwasser C. 2013. Obesity promotes breast cancer by CCL2-mediated macrophage recruitment and angiogenesis.. In: . . MGI: J:202607
Ashkar AA; Di Santo JP; Croy BA. 2000. Interferon gamma contributes to initiation of uterine vascular modification, decidual integrity, and uterine natural killer cell maturation during normal murine pregnancy [see comments]. In: . . MGI: J:63645
Aspord C; Rome S; Thivolet C. 2004. Early events in islets and pancreatic lymph nodes in autoimmune diabetes.. In: . . MGI: J:91668
Augstein P; Stephens LA; Allison J; Elefanty AG; Ekberg M; Kay TW; Harrison LC. 1998. Beta-cell apoptosis in an accelerated model of autoimmune diabetes.. In: . . MGI: J:133840
Babu S; Porte P; Klei TR; Shultz LD; Rajan TV. 1998. Host NK cells are required for the growth of the human filarial parasite Brugia malayi in mice.. In: . . MGI: J:49819
Baerenwaldt A; Lux A; Danzer H; Spriewald BM; Ullrich E; Heidkamp G; Dudziak D; Nimmerjahn F. 2011. Fcgamma receptor IIB (FcgammaRIIB) maintains humoral tolerance in the human immune system in vivo.. In: . . MGI: J:180174
Baker RL; Delong T; Barbour G; Bradley B; Nakayama M; Haskins K. 2013. Cutting edge: CD4 T cells reactive to an islet amyloid polypeptide peptide accumulate in the pancreas and contribute to disease pathogenesis in nonobese diabetic mice.. In: . . MGI: J:206266
Balasa B; La Cava A; Van Gunst K; Mocnik L; Balakrishna D; Nguyen N; Tucker L; Sarvetnick N. 2000. A mechanism for IL-10-mediated diabetes in the nonobese diabetic (NOD) mouse: ICAM-1 deficiency blocks accelerated diabetes. In: . . MGI: J:66103
Balavenkatraman KK; Aceto N; Britschgi A; Mueller U; Bence KK; Neel BG; Bentires-Alj M. 2011. Epithelial protein-tyrosine phosphatase 1B contributes to the induction of mammary tumors by HER2/Neu but is not essential for tumor maintenance.. In: . . MGI: J:205401
Baleriola J; Suarez T; de la Rosa EJ. 2010. DNA-PK promotes the survival of young neurons in the embryonic mouse retina.. In: . . MGI: J:186357
Ballas ZK; Buchta CM; Rosean TR; Heusel JW; Shey MR. 2013. Role of NK cell subsets in organ-specific murine melanoma metastasis.. In: . . MGI: J:204234
Bandeira M; Santos CS; de Azevedo EC; Soares LM; Macedo JO; Marchi S; da Silva CL; Chagas-Junior AD; McBride AJ; McBride FW; Reis MG; Athanazio DA. 2011. Attenuated Nephritis in Inducible Nitric Oxide Synthase Knockout C57BL/6 Mice and Pulmonary Hemorrhage in CB17 SCID and Recombination Activating Gene 1 Knockout C57BL/6 Mice Infected with Leptospira interrogans.. In: . . MGI: J:173478
Bandi S; Joseph B; Berishvili E; Singhania R; Wu YM; Cheng K; Gupta S. 2011. Perturbations in ataxia telangiectasia mutant signaling pathways after drug-induced acute liver failure and their reversal during rescue of animals by cell therapy.. In: . . MGI: J:168235
Banerjee P; Tripp A; Lairmore MD; Crawford L; Sieburg M; Ramos JC; Harrington W Jr; Beilke MA; Feuer G. 2010. Adult T-cell leukemia/lymphoma development in HTLV-1-infected humanized SCID mice.. In: . . MGI: J:162610
Banga SS; Hall KT; Sandhu AK; Weaver DT; Athwal RS. 1994. Complementation of V(D)J recombination defect and X-ray sensitivity of scid mouse cells by human chromosome 8.. In: . . MGI: J:21219
Banuelos SJ; Shultz LD; Greiner DL; Burzenski LM; Gott B; Lyons BL; Rossini AA; Appel MC. 2004. Rejection of human islets and human HLA-A2.1 transgenic mouse islets by alloreactive human lymphocytes in immunodeficient NOD-scid and NOD-Rag1(null)Prf1(null) mice.. In: . . MGI: J:91764
Bao L; Haas M; Pippin J; Wang Y; Miwa T; Chang A; Minto AW; Petkova M; Qiao G; Song WC; Alpers CE; Zhang J; Shankland SJ; Quigg RJ. 2009. Focal and segmental glomerulosclerosis induced in mice lacking decay-accelerating factor in T cells.. In: . . MGI: J:149592
Barber RC; Miccoli L; van Buul PP; Burr KL; van Duyn-Goedhart A; Angulo JF; Dubrova YE. 2004. Germline mutation rates at tandem repeat loci in DNA-repair deficient mice.. In: . . MGI: J:93788
Bardeesy N; Kim M; Xu J; Kim RS; Shen Q; Bosenberg MW; Wong WH; Chin L. 2005. Role of epidermal growth factor receptor signaling in RAS-driven melanoma.. In: . . MGI: J:99136
Barrette B; Hebert MA; Filali M; Lafortune K; Vallieres N; Gowing G; Julien JP; Lacroix S. 2008. Requirement of myeloid cells for axon regeneration.. In: . . MGI: J:142759
Barroso-delJesus A; Lucena-Aguilar G; Sanchez L; Ligero G; Gutierrez-Aranda I; Menendez P. 2011. The Nodal inhibitor Lefty is negatively modulated by the microRNA miR-302 in human embryonic stem cells.. In: . . MGI: J:172780
Barthold SW; Hodzic E; Tunev S; Feng S. 2006. Antibody-mediated disease remission in the mouse model of lyme borreliosis.. In: . . MGI: J:112329
Battaglia M; Stabilini A; Draghici E; Migliavacca B; Gregori S; Bonifacio E; Roncarolo MG. 2006. Induction of Tolerance in Type 1 Diabetes via Both CD4+CD25+ T Regulatory Cells and T Regulatory Type 1 Cells.. In: . . MGI: J:111884
Beamer WG; Shultz KL; Tennent BJ; Shultz LD. 1993. Granulosa cell tumorigenesis in genetically hypogonadal-immunodeficient mice grafted with ovaries from tumor-susceptible donors.. In: . . MGI: J:14443
Belkaid Y; Mendez S; Lira R; Kadambi N; Milon G; Sacks D. 2000. A natural model of Leishmania major infection reveals a prolonged 'silent' phase of parasite amplification in the skin before the onset of lesion formation and immunity.. In: . . MGI: J:120233
Bellani MA; Romanienko PJ; Cairatti DA; Camerini-Otero RD. 2005. SPO11 is required for sex-body formation, and Spo11 heterozygosity rescues the prophase arrest of Atm-/- spermatocytes.. In: . . MGI: J:100203
Bello-Irizarry SN; Wang J; Johnston CJ; Gigliotti F; Wright TW. 2014. MyD88 signaling regulates both host defense and immunopathogenesis during pneumocystis infection.. In: . . MGI: J:207087
Benavente CA; McEvoy JD; Finkelstein D; Wei L; Kang G; Wang YD; Neale G; Ragsdale S; Valentine V; Bahrami A; Temirov J; Pounds S; Zhang J; Dyer MA. 2013. Cross-species genomic and epigenomic landscape of retinoblastoma.. In: . . MGI: J:207640
Benner EJ; Banerjee R; Reynolds AD; Sherman S; Pisarev VM; Tsiperson V; Nemachek C; Ciborowski P; Przedborski S; Mosley RL; Gendelman HE. 2008. Nitrated alpha-Synuclein Immunity Accelerates Degeneration of Nigral Dopaminergic Neurons.. In: . . MGI: J:131300
Bertin A. 1992. Comparison of susceptibility of inbred and outbred infant mice to Escherichia coli heat-stable enterotoxin STa.. In: . . MGI: J:2117
Bettini M; Castellaw AH; Lennon GP; Burton AR; Vignali DA. 2012. Prevention of autoimmune diabetes by ectopic pancreatic beta-cell expression of interleukin-35.. In: . . MGI: J:196852
Biedermann KA; Sun JR; Giaccia AJ; Tosto LM; Brown JM. 1991. scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair.. In: . . MGI: J:89590
Billerbeck E; Horwitz JA; Labitt RN; Donovan BM; Vega K; Budell WC; Koo GC; Rice CM; Ploss A. 2013. Characterization of human antiviral adaptive immune responses during hepatotropic virus infection in HLA-transgenic human immune system mice.. In: . . MGI: J:205706
Binder GK; Griffin DE. 2001. Interferon-gamma-mediated site-specific clearance of alphavirus from CNS neurons.. In: . . MGI: J:125465
Bitsaktsis C; Huntington J; Winslow G. 2004. Production of IFN-gamma by CD4 T cells is essential for resolving ehrlichia infection.. In: . . MGI: J:90518
Blanc L; Ciciotte SL; Gwynn B; Hildick-Smith GJ; Pierce EL; Soltis KA; Cooney JD; Paw BH; Peters LL. 2012. Critical function for the Ras-GTPase activating protein RASA3 in vertebrate erythropoiesis and megakaryopoiesis.. In: . . MGI: J:186485
Blunt T; Gell D; Fox M; Taccioli GE; Lehmann AR; Jackson SP; Jeggo PA. 1996. Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse.. In: . . MGI: J:35393
Bobbala D; Chen XL; Leblanc C; Mayhue M; Stankova J; Tanaka T; Chen YG; Ilangumaran S; Ramanathan S. 2012. Interleukin-15 plays an essential role in the pathogenesis of autoimmune diabetes in the NOD mouse.. In: . . MGI: J:191833
Bobbala D; Kandhi R; Chen X; Mayhue M; Bouchard E; Yan J; Knecht H; Barabe F; Ramanathan S; Ilangumaran S. 2016. Interleukin-15 deficiency promotes the development of T-cell acute lymphoblastic leukemia in non-obese diabetes mice with severe combined immunodeficiency.. In: . . MGI: J:233962
Boggiatto PM; Jie F; Ghosh M; Gibson-Corley KN; Ramer-Tait AE; Jones DE; Petersen CA. 2009. Altered dendritic cell phenotype in response to Leishmania amazonensis amastigote infection is mediated by MAP kinase, ERK.. In: . . MGI: J:147971
Bogue MA; Zhu C; Aguilar-Cordova E; Donehower LA; Roth DB. 1996. p53 is required for both radiation-induced differentiation and rescue of V(D)J rearrangement in scid mouse thymocytes.. In: . . MGI: J:31868
Boitano AE; Wang J; Romeo R; Bouchez LC; Parker AE; Sutton SE; Walker JR; Flaveny CA; Perdew GH; Denison MS; Schultz PG; Cooke MP. 2010. Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells.. In: . . MGI: J:167433
Boldizsar F; Tarjanyi O; Nemeth P; Mikecz K; Glant TT. 2009. Th1/Th17 polarization and acquisition of an arthritogenic phenotype in arthritis-susceptible BALB/c, but not in MHC-matched, arthritis-resistant DBA/2 mice.. In: . . MGI: J:148186
Bolz DD; Sundsbak RS; Ma Y; Akira S; Kirschning CJ; Zachary JF; Weis JH; Weis JJ. 2004. MyD88 plays a unique role in host defense but not arthritis development in Lyme disease.. In: . . MGI: J:92031
Bolz DD; Sundsbak RS; Ma Y; Akira S; Weis JH; Schwan TG; Weis JJ. 2006. Dual role of MyD88 in rapid clearance of relapsing fever Borrelia spp.. In: . . MGI: J:116070
Bonifazi P; Zelante T; D'Angelo C; De Luca A; Moretti S; Bozza S; Perruccio K; Iannitti RG; Giovannini G; Volpi C; Fallarino F; Puccetti P; Romani L. 2009. Balancing inflammation and tolerance in vivo through dendritic cells by the commensal Candida albicans.. In: . . MGI: J:193381
Bosma GC; Custer RP; Bosma MJ. 1983. A severe combined immunodeficiency mutation in the mouse.. In: . . MGI: J:6958
Bosma GC; Oshinsky J; Kiefer K; Nakajima PB; Charan D; Congelton C; Radic M; Bosma MJ. 2006. Development of functional B cells in a line of SCID mice with transgenes coding for anti-double-stranded DNA antibody.. In: . . MGI: J:126632
Bosma M; Schuler W; Bosma G. 1988. The scid mouse mutant.. In: . . MGI: J:9341
Boyartchuk V; Rojas M; Yan BS; Jobe O; Hurt N; Dorfman DM; Higgins DE; Dietrich WF; Kramnik I. 2004. The host resistance locus sst1 controls innate immunity to Listeria monocytogenes infection in immunodeficient mice.. In: . . MGI: J:93705
Brackett CM; Kojouharov B; Veith J; Greene KF; Burdelya LG; Gollnick SO; Abrams SI; Gudkov AV. 2016. Toll-like receptor-5 agonist, entolimod, suppresses metastasis and induces immunity by stimulating an NK-dendritic-CD8+ T-cell axis.. In: . . MGI: J:230433
Braumuller H; Wieder T; Brenner E; Assmann S; Hahn M; Alkhaled M; Schilbach K; Essmann F; Kneilling M; Griessinger C; Ranta F; Ullrich S; Mocikat R; Braungart K; Mehra T; Fehrenbacher B; Berdel J; Niessner H; Meier F; van den Broek M; Haring HU; Handgretinger R; Quintanilla-Martinez L; Fend F; Pesic M; Bauer J; Zender L; Schaller M; Schulze-Osthoff K; Rocken M. 2013. T-helper-1-cell cytokines drive cancer into senescence.. In: . . MGI: J:194546
Bregenholt S; Claesson MH. 1998. Splenic T helper cell type 1 cytokine profile and extramedullary haematopoiesis in severe combined immunodeficient (scid) mice with inflammatory bowel disease (IBD).. In: . . MGI: J:45450
Bregenholt S; Claesson MH. 1998. Increased intracellular Th1 cytokines in scid mice with inflammatory bowel disease.. In: . . MGI: J:45906
Brehm MA; Racki WJ; Leif J; Burzenski L; Hosur V; Wetmore A; Gott B; Herlihy M; Ignotz R; Dunn R; Shultz LD; Greiner DL. 2012. Engraftment of human HSC in non-irradiated newborn NOD-scid IL2rgammanull mice is enhanced by transgenic expression of membrane-bound human SCF.. In: . . MGI: J:180273
Brem-Exner BG; Sattler C; Hutchinson JA; Koehl GE; Kronenberg K; Farkas S; Inoue S; Blank C; Knechtle SJ; Schlitt HJ; Fandrich F; Geissler EK. 2008. Macrophages driven to a novel state of activation have anti-inflammatory properties in mice.. In: . . MGI: J:130932
Bridgett M; Cetkovic-Cvrlje M; O'Rourke R; Shi Y; Narayanswami S; Lambert J; Ramiya V; Baekkeskov S; Leiter EH. 1998. Differential protection in two transgenic lines of NOD/Lt mice hyperexpressing the autoantigen GAD65 in pancreatic beta-cells.. In: . . MGI: J:100251
Browning JL; Allaire N; Ngam-Ek A; Notidis E; Hunt J; Perrin S; Fava RA. 2005. Lymphotoxin-beta receptor signaling is required for the homeostatic control of HEV differentiation and function.. In: . . MGI: J:113284
Bruedigam C; Bagger FO; Heidel FH; Paine Kuhn C; Guignes S; Song A; Austin R; Vu T; Lee E; Riyat S; Moore AS; Lock RB; Bullinger L; Hill GR; Armstrong SA; Williams DA; Lane SW. 2014. Telomerase inhibition effectively targets mouse and human AML stem cells and delays relapse following chemotherapy.. In: . . MGI: J:223853
Bueno C; Lopes LF; Greaves M; Menendez P. 2007. Toward development of a novel NOD/SCID-based in vivo strategy to model multiple myeloma pathogenesis.. In: . . MGI: J:126691
Bugl S; Wirths S; Radsak MP; Schild H; Stein P; Andre MC; Muller MR; Malenke E; Wiesner T; Marklin M; Frick JS; Handgretinger R; Rammensee HG; Kanz L; Kopp HG. 2013. Steady-state neutrophil homeostasis is dependent on TLR4/TRIF signaling.. In: . . MGI: J:194620
Bumgardner GL; Gao D; Li J; Baskin JH; Heininger M; Orosz CG. 2000. Rejection responses to allogeneic hepatocytes by reconstituted SCID mice, CD4, KO, and CD8 KO mice.. In: . . MGI: J:66571
Buning J; Schmitz M; Repenning B; Ludwig D; Schmidt MA; Strobel S; Zimmer KP. 2005. Interferon-gamma mediates antigen trafficking to MHC class II-positive late endosomes of enterocytes.. In: . . MGI: J:96737
Burdeinick-Kerr R; Wind J; Griffin DE. 2007. Synergistic roles of antibody and interferon in noncytolytic clearance of Sindbis virus from different regions of the central nervous system.. In: . . MGI: J:153321
Burke SD; Barrette VF; Carter AL; Gravel J; Adams MA; Croy BA. 2011. Cardiovascular adaptations of pregnancy in T and B cell-deficient mice.. In: . . MGI: J:176701
Burr KL; Smith AG; Dubrova YE. 2005. p53 deficiency does not affect mutation rate in the mouse germline.. In: . . MGI: J:99550
Butler JM; Nolan DJ; Vertes EL; Varnum-Finney B; Kobayashi H; Hooper AT; Seandel M; Shido K; White IA; Kobayashi M; Witte L; May C; Shawber C; Kimura Y; Kitajewski J; Rosenwaks Z; Bernstein ID; Rafii S. 2010. Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells.. In: . . MGI: J:158983
Calderon B; Suri A; Unanue ER. 2006. In CD4+ T-cell-induced diabetes, macrophages are the final effector cells that mediate islet beta-cell killing: studies from an acute model.. In: . . MGI: J:116218
Callen E; Jankovic M; Wong N; Zha S; Chen HT; Difilippantonio S; Di Virgilio M; Heidkamp G; Alt FW; Nussenzweig A; Nussenzweig M. 2009. Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes.. In: . . MGI: J:150435
Carrero JA; Calderon B; Unanue ER. 2006. Lymphocytes are detrimental during the early innate immune response against Listeria monocytogenes.. In: . . MGI: J:123753
Carter CR; Whitcomb JP; Campbell JA; Mukbel RM; McDowell MA. 2009. Complement receptor 3 deficiency influences lesion progression during Leishmania major infection in BALB/c mice.. In: . . MGI: J:155481
Chakraborty P; Buaas FW; Sharma M; Snyder E; de Rooij DG; Braun RE. 2014. LIN28A marks the spermatogonial progenitor population and regulates its cyclic expansion.. In: . . MGI: J:210438
Chang Y; Bosma GC; Bosma MJ. 1995. Development of B cells in scid mice with immunoglobulin transgenes: implications for the control of V(D)J recombination.. In: . . MGI: J:27341
Chang Y; Bosma MJ. 1997. Effect of different Ig transgenes on B cell differentiation in scid mice.. In: . . MGI: J:125479
Chaparro RJ; Konigshofer Y; Beilhack GF; Shizuru JA; McDevitt HO; Chien YH. 2006. Nonobese diabetic mice express aspects of both type 1 and type 2 diabetes.. In: . . MGI: J:111775
Chen AM; Zhou Y; Swenson K; Sachs DH; Sykes M; Yang YG. 2000. Porcine stem cell engraftment and seeding of murine thymus with class II+ cells in mice expressing porcine cytokines: toward tolerance induction across discordant xenogeneic barriers.. In: . . MGI: J:93486
Chen CC; Murray PJ; Jiang TX; Plikus MV; Chang YT; Lee OK; Widelitz RB; Chuong CM. 2014. Regenerative hair waves in aging mice and extra-follicular modulators follistatin, dkk1, and sfrp4.. In: . . MGI: J:212840
Chen CH; Yeh YC; Wu GJ; Huang YH; Lai WF; Liu JY; Tzeng CR. 2010. Tracking the rejection and survival of mouse ovarian iso- and allografts in vivo with bioluminescent imaging.. In: . . MGI: J:175817
Chen D; Pacal M; Wenzel P; Knoepfler PS; Leone G; Bremner R. 2009. Division and apoptosis of E2f-deficient retinal progenitors.. In: . . MGI: J:155800
Chen G; Han G; Wang J; Wang R; Xu R; Shen B; Qian J; Li Y. 2009. Natural killer cells modulate overt autoimmunity to homeostasis in nonobese diabetic mice after anti-CD3 F(ab')2 antibody treatment through secreting transforming growth factor-beta.. In: . . MGI: J:152908
Chen J; Chen YG; Reifsnyder PC; Schott WH; Lee CH; Osborne M; Scheuplein F; Haag F; Koch-Nolte F; Serreze DV; Leiter EH. 2006. Targeted disruption of CD38 accelerates autoimmune diabetes in NOD/Lt mice by enhancing autoimmunity in an ADP-ribosyltransferase 2-dependent fashion.. In: . . MGI: J:108097
Chen J; Gusdon AM; Piganelli J; Leiter EH; Mathews CE. 2011. mt-Nd2(a) Modifies resistance against autoimmune type 1 diabetes in NOD mice at the level of the pancreatic beta-cell.. In: . . MGI: J:170153
Chen Q; Amaladoss A; Ye W; Liu M; Dummler S; Kong F; Wong LH; Loo HL; Loh E; Tan SQ; Tan TC; Chang KT; Dao M; Suresh S; Preiser PR; Chen J. 2014. Human natural killer cells control Plasmodium falciparum infection by eliminating infected red blood cells.. In: . . MGI: J:206650
Chen YT; Chen FY; Vijmasi T; Stephens DN; Gallup M; McNamara NA. 2013. Pax6 downregulation mediates abnormal lineage commitment of the ocular surface epithelium in aqueous-deficient dry eye disease.. In: . . MGI: J:209118
Chen Z; Zhang Y; Jia C; Wang Y; Lai P; Zhou X; Wang Y; Song Q; Lin J; Ren Z; Gao Q; Zhao Z; Zheng H; Wan Z; Gao T; Zhao A; Dai Y; Bai X. 2014. mTORC1/2 targeted by n-3 polyunsaturated fatty acids in the prevention of mammary tumorigenesis and tumor progression.. In: . . MGI: J:214352
Cheung KJ; Padmanaban V; Silvestri V; Schipper K; Cohen JD; Fairchild AN; Gorin MA; Verdone JE; Pienta KJ; Bader JS; Ewald AJ. 2016. Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters.. In: . . MGI: J:230438
Chi X; Zhi L; Gelderman MP; Vostal JG. 2012. Host platelets and, in part, neutrophils mediate lung accumulation of transfused UVB-irradiated human platelets in a mouse model of acute lung injury.. In: . . MGI: J:191794
Chiang EY; Stroynowski I. 2004. A nonclassical MHC class I molecule restricts CTL-mediated rejection of a syngeneic melanoma tumor.. In: . . MGI: J:93729
Chiaraviglio L; Duong S; Brown DA; Birtles RJ; Kirby JE. 2010. An immunocompromised murine model of chronic Bartonella infection.. In: . . MGI: J:161161
Chirieleison SM; Feduska JM; Schugar RC; Askew Y; Deasy BM. 2012. Human muscle-derived cell populations isolated by differential adhesion rates: phenotype and contribution to skeletal muscle regeneration in Mdx/SCID mice.. In: . . MGI: J:181239
Chiu IM; Heesters BA; Ghasemlou N; Von Hehn CA; Zhao F; Tran J; Wainger B; Strominger A; Muralidharan S; Horswill AR; Bubeck Wardenburg J; Hwang SW; Carroll MC; Woolf CJ. 2013. Bacteria activate sensory neurons that modulate pain and inflammation.. In: . . MGI: J:205431
Choi B; Chun E; Kim M; Kim SY; Kim ST; Yoon K; Lee KY; Kim SJ. 2011. Human T cell development in the liver of humanized NOD/SCID/IL-2Rgamma(null)(NSG) mice generated by intrahepatic injection of CD34(+) human (h) cord blood (CB) cells.. In: . . MGI: J:173961
Choi S; Chen Z; Tang LH; Fang Y; Shin SJ; Panarelli NC; Chen YT; Li Y; Jiang X; Du YC. 2016. Bcl-xL promotes metastasis independent of its anti-apoptotic activity.. In: . . MGI: J:235886
Chou FC; Shieh SJ; Sytwu HK. 2009. Attenuation of Th1 response through galectin-9 and T-cell Ig mucin 3 interaction inhibits autoimmune diabetes in NOD mice.. In: . . MGI: J:152168
Chow LH. 1993. Studies of virus-induced myocardial injury in mice: value of the scid mutation on different genetic backgrounds and combined with other mutations.. In: . . MGI: J:12476
Christianson SW; Greiner DL; Hesselton RA; Leif JH; Wagar EJ; Schweitzer IB; Rajan TV; Gott B; Roopenian DC; Shultz LD. 1997. Enhanced human CD4+ T cell engraftment in beta2-microglobulin-deficient NOD-scid mice.. In: . . MGI: J:102141
Christianson SW; Greiner DL; Schweitzer IB; Gott B; Beamer GL; Schweitzer PA; Hesselton RM; Shultz LD. 1996. Role of natural killer cells on engraftment of human lymphoid cells and on metastasis of human T-lymphoblastoid leukemia cells in C57BL/6J-scid mice and in C57BL/6J-scid bg mice.. In: . . MGI: J:34814
Clark CA; Gupta HB; Sareddy G; Pandeswara S; Lao S; Yuan B; Drerup JM; Padron A; Conejo-Garcia J; Murthy K; Liu Y; Turk MJ; Thedieck K; Hurez V; Li R; Vadlamudi R; Curiel TJ. 2016. Tumor-Intrinsic PD-L1 Signals Regulate Cell Growth, Pathogenesis, and Autophagy in Ovarian Cancer and Melanoma.. In: . . MGI: J:237848
Clemente-Casares X; Blanco J; Ambalavanan P; Yamanouchi J; Singha S; Fandos C; Tsai S; Wang J; Garabatos N; Izquierdo C; Agrawal S; Keough MB; Yong VW; James E; Moore A; Yang Y; Stratmann T; Serra P; Santamaria P. 2016. Expanding antigen-specific regulatory networks to treat autoimmunity.. In: . . MGI: J:229667
Cleveland SM; Smith S; Tripathi R; Mathias EM; Goodings C; Elliott N; Peng D; El-Rifai W; Yi D; Chen X; Li L; Mullighan C; Downing JR; Love P; Dave UP. 2013. Lmo2 induces hematopoietic stem cell-like features in T-cell progenitor cells prior to leukemia.. In: . . MGI: J:196312
Cook AJ; Oganesian L; Harumal P; Basten A; Brink R; Jolly CJ. 2003. Reduced switching in SCID B cells is associated with altered somatic mutation of recombined S regions.. In: . . MGI: J:117994
Coombes JL; Siddiqui KR; Arancibia-Carcamo CV; Hall J; Sun CM; Belkaid Y; Powrie F. 2007. A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism.. In: . . MGI: J:203901
Coppola V; Barrick CA; Southon EA; Celeste A; Wang K; Chen B; Haddad el-B; Yin J; Nussenzweig A; Subramaniam A; Tessarollo L. 2004. Ablation of TrkA function in the immune system causes B cell abnormalities.. In: . . MGI: J:93578
Cosgun KN; Rahmig S; Mende N; Reinke S; Hauber I; Schafer C; Petzold A; Weisbach H; Heidkamp G; Purbojo A; Cesnjevar R; Platz A; Bornhauser M; Schmitz M; Dudziak D; Hauber J; Kirberg J; Waskow C. 2014. Kit regulates HSC engraftment across the human-mouse species barrier.. In: . . MGI: J:232320
Coughlan AM; Harmon C; Whelan S; O'Brien EC; O'Reilly VP; Crotty P; Kelly P; Ryan M; Hickey FB; O'Farrelly C; Little MA. 2016. Myeloid Engraftment in Humanized Mice: Impact of Granulocyte-Colony Stimulating Factor Treatment and Transgenic Mouse Strain.. In: . . MGI: J:230785
Covassin L; Jangalwe S; Jouvet N; Laning J; Burzenski L; Shultz LD; Brehm MA. 2013. Human immune system development and survival of NOD-scid IL2rgamma (NSG) mice engrafted with human thymus and autologous hematopoietic stem cells.. In: . . MGI: J:200896
Covassin L; Laning J; Abdi R; Langevin DL; Phillips NE; Shultz LD; Brehm MA. 2011. Human peripheral blood CD4 T cell-engrafted non-obese diabetic-scid IL2rgamma(null) H2-Ab1 (tm1Gru) Tg (human leucocyte antigen D-related 4) mice: a mouse model of human allogeneic graft-versus-host disease.. In: . . MGI: J:177904
Craven AJ; Nixon AJ; Ashby MG; Ormandy CJ; Blazek K; Wilkins RJ; Pearson AJ. 2006. Prolactin delays hair regrowth in mice.. In: . . MGI: J:114701
Crowe MJ; Doetschman T; Greenhalgh DG. 2000. Delayed wound healing in immunodeficient TGF-beta1 knockout mice. In: . . MGI: J:63260
Crowley SD; Song YS; Lin EE; Griffiths R; Kim HS; Ruiz P. 2010. Lymphocyte responses exacerbate angiotensin II-dependent hypertension.. In: . . MGI: J:158609
Culmsee C; Bondada S; Mattson MP. 2001. Hippocampal neurons of mice deficient in DNA-dependent protein kinase exhibit increased vulnerability to DNA damage, oxidative stress and excitotoxicity.. In: . . MGI: J:109293
Cupedo T; Lund FE; Ngo VN; Randall TD; Jansen W; Greuter MJ; de Waal-Malefyt R; Kraal G; Cyster JG; Mebius RE. 2004. Initiation of cellular organization in lymph nodes is regulated by non-B cell-derived signals and is not dependent on CXC chemokine ligand 13.. In: . . MGI: J:93711
Custer RP; Bosma GC; Bosma MJ. 1985. Severe combined immunodeficiency (SCID) in the mouse. Pathology, reconstitution, neoplasms.. In: . . MGI: J:30980
D'Aveni M; Rossignol J; Coman T; Sivakumaran S; Henderson S; Manzo T; Santos e Sousa P; Bruneau J; Fouquet G; Zavala F; Alegria-Prevot O; Garfa-Traore M; Suarez F; Trebeden-Negre H; Mohty M; Bennett CL; Chakraverty R; Hermine O; Rubio MT. 2015. G-CSF mobilizes CD34+ regulatory monocytes that inhibit graft-versus-host disease.. In: . . MGI: J:234081
Dann SM; Spehlmann ME; Hammond DC; Iimura M; Hase K; Choi LJ; Hanson E; Eckmann L. 2008. IL-6-dependent mucosal protection prevents establishment of a microbial niche for attaching/effacing lesion-forming enteric bacterial pathogens.. In: . . MGI: J:134871
Danska JS; Holland DP; Mariathasan S; Williams KM; Guidos CJ. 1996. Biochemical and genetic defects in the DNA-dependent protein kinase in murine scid lymphocytes.. In: . . MGI: J:35350
Darwiche R; Chong MM; Santamaria P; Thomas HE; Kay TW. 2003. Fas is detectable on beta cells in accelerated, but not spontaneous, diabetes in nonobese diabetic mice.. In: . . MGI: J:108698
Das R; Bassiri H; Guan P; Wiener S; Banerjee PP; Zhong MC; Veillette A; Orange JS; Nichols KE. 2013. The adaptor molecule SAP plays essential roles during invariant NKT cell cytotoxicity and lytic synapse formation.. In: . . MGI: J:196692
De Luca A; Carvalho A; Cunha C; Iannitti RG; Pitzurra L; Giovannini G; Mencacci A; Bartolommei L; Moretti S; Massi-Benedetti C; Fuchs D; De Bernardis F; Puccetti P; Romani L. 2013. IL-22 and IDO1 affect immunity and tolerance to murine and human vaginal candidiasis.. In: . . MGI: J:213365
De Palma M; Venneri MA; Galli R; Sergi LS; Politi LS; Sampaolesi M; Naldini L. 2005. Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors.. In: . . MGI: J:102241
Derecki NC; Cardani AN; Yang CH; Quinnies KM; Crihfield A; Lynch KR; Kipnis J. 2010. Regulation of learning and memory by meningeal immunity: a key role for IL-4.. In: . . MGI: J:160932
DiLorenzo TP; Lieberman SM; Takaki T; Honda S; Chapman HD; Santamaria P; Serreze DV; Nathenson SG. 2002. During the early prediabetic period in NOD mice, the pathogenic CD8(+) T-cell population comprises multiple antigenic specificities.. In: . . MGI: J:94192
Diamond RA; Ward SB; Owada-Makabe K; Wang H; Rothenberg EV. 1997. Different developmental arrest points in RAG-2 -/- and SCID thymocytes on two genetic backgrounds: developmental choices and cell death mechanisms before TCR gene rearrangement.. In: . . MGI: J:39793
Diaz-Manera J; Touvier T; Dellavalle A; Tonlorenzi R; Tedesco FS; Messina G; Meregalli M; Navarro C; Perani L; Bonfanti C; Illa I; Torrente Y; Cossu G. 2010. Partial dysferlin reconstitution by adult murine mesoangioblasts is sufficient for full functional recovery in a murine model of dysferlinopathy.. In: . . MGI: J:186461
Dibra D; Cutrera JJ; Li S. 2012. Coordination between TLR9 signaling in macrophages and CD3 signaling in T cells induces robust expression of IL-30.. In: . . MGI: J:184078
Dodig TD; Mack KT; Cassarino DF; Clark SH. 2001. Development of the tight-skin phenotype in immune-deficient mice.. In: . . MGI: J:112962
Doherty TM; Sher A. 1997. Defects in cell-mediated immunity affect chronic, but not innate, resistance of mice to Mycobacterium avium infection.. In: . . MGI: J:40202
Dohi T; Fujihashi K; Koga T; Etani Y; Yoshino N; Kawamura YI; McGhee JR. 2004. CD4+CD45RBHi interleukin-4 defective T cells elicit antral gastritis and duodenitis.. In: . . MGI: J:93676
Dohi T; Fujihashi K; Koga T; Shirai Y; Kawamura YI; Ejima C; Kato R; Saitoh K; McGhee JR. 2003. T helper type-2 cells induce ileal villus atrophy, goblet cell metaplasia, and wasting disease in T cell-deficient mice.. In: . . MGI: J:82106
Dominique V; Francis L. 1995. Interactions of the scid or beige mutations with the viable motheaten mutation.. In: . . MGI: J:33985
Dorshkind K; Keller GM; Phillips RA; Miller RG; Bosma GC; O'Toole M; Bosma MJ. 1984. Functional status of cells from lymphoid and myeloid tissues in mice with severe combined immunodeficiency disease.. In: . . MGI: J:7343
Dos Santos C; McDonald T; Ho YW; Liu H; Lin A; Forman SJ; Kuo YH; Bhatia R. 2013. The Src and c-Kit kinase inhibitor dasatinib enhances p53-mediated targeting of human acute myeloid leukemia stem cells by chemotherapeutic agents.. In: . . MGI: J:202360
Dreyer AM; Matile H; Papastogiannidis P; Kamber J; Favuzza P; Voss TS; Wittlin S; Pluschke G. 2012. Passive immunoprotection of Plasmodium falciparum-infected mice designates the CyRPA as candidate malaria vaccine antigen.. In: . . MGI: J:188965
Dudek NL; Thomas HE; Mariana L; Sutherland RM; Allison J; Estella E; Angstetra E; Trapani JA; Santamaria P; Lew AM; Kay TW. 2006. Cytotoxic T-cells from T-cell receptor transgenic NOD8.3 mice destroy beta-cells via the perforin and Fas pathways.. In: . . MGI: J:116592
Dudley ME; Sundberg JP; Roopenian DC. 1996. Frequency and histological appearance of adenomas in multiple intestinal neoplasia mice are unaffected by severe combined immunodeficiency (scid) mutation.. In: . . MGI: J:31690
Dullin C; Missbach-Guentner J; Vogel WF; Grabbe E; Alves F. 2007. Semi-Automatic Classification of Skeletal Morphology in Genetically Altered Mice Using Flat-Panel Volume Computed Tomography.. In: . . MGI: J:123719
Dumont N; Boyer L; Emond H; Celebi-Saltik B; Pasha R; Bazin R; Mantovani D; Roy DC; Pineault N. 2014. Medium conditioned with mesenchymal stromal cell-derived osteoblasts improves the expansion and engraftment properties of cord blood progenitors.. In: . . MGI: J:214003
Eaton KA; Benson LH; Haeger J; Gray BM. 2006. Role of transcription factor T-bet expression by CD4+ cells in gastritis due to Helicobacter pylori in mice.. In: . . MGI: J:112403
Eaton KA; Mefford M; Thevenot T. 2001. The role of T cell subsets and cytokines in the pathogenesis of Helicobacter pylori gastritis in mice.. In: . . MGI: J:124425
Ebrahem Q; Chaurasia SS; Vasanji A; Qi JH; Klenotic PA; Cutler A; Asosingh K; Erzurum S; Anand-Apte B. 2010. Cross-talk between vascular endothelial growth factor and matrix metalloproteinases in the induction of neovascularization in vivo.. In: . . MGI: J:156380
Economopoulos V; Noad JC; Krishnamoorthy S; Rutt BK; Foster PJ. 2011. Comparing the MRI appearance of the lymph nodes and spleen in wild-type and immuno-deficient mouse strains.. In: . . MGI: J:180968
Elsegeiny W; Eddens T; Chen K; Kolls JK. 2015. Anti-CD20 antibody therapy and susceptibility to Pneumocystis pneumonia.. In: . . MGI: J:229720
Emoto M; Mittrucker HW; Schmits R; Mak TW; Kaufmann SH. 1999. Critical role of leukocyte function-associated antigen-1 in liver accumulation of CD4+NKT cells.. In: . . MGI: J:111009
Engle SJ; Ormsby I; Pawlowski S; Boivin GP; Croft J; Balish E; Doetschman T. 2002. Elimination of Colon Cancer in Germ-free Transforming Growth Factor Beta 1-deficient Mice.. In: . . MGI: J:80209
English WR; Lunt SJ; Fisher M; Lefley DV; Dhingra M; Lee YC; Bingham K; Hurrell JE; Lyons SK; Kanthou C; Tozer GM. 2017. Differential Expression of VEGFA Isoforms Regulates Metastasis and Response to Anti-VEGFA Therapy in Sarcoma.. In: . . MGI: J:242299
Ernst PB; Erickson LD; Loo WM; Scott KG; Wiznerowicz EB; Brown CC; Torres-Velez FJ; Alam MS; Black SG; McDuffie M; Feldman SH; Wallace JL; McKnight GW; Padol IT; Hunt RH; Tung KS. 2012. Spontaneous autoimmune gastritis and hypochlorhydria are manifest in the ileitis-prone SAMP1/YitFcs mice.. In: . . MGI: J:183342
Eyob H; Ekiz HA; Derose YS; Waltz SE; Williams MA; Welm AL. 2013. Inhibition of ron kinase blocks conversion of micrometastases to overt metastases by boosting antitumor immunity.. In: . . MGI: J:203569
Fahlen L; Read S; Gorelik L; Hurst SD; Coffman RL; Flavell RA; Powrie F. 2005. T cells that cannot respond to TGF-{beta} escape control by CD4+CD25+ regulatory T cells.. In: . . MGI: J:96624
Faleo G; Fotino C; Bocca N; Molano RD; Zahr-Akrawi E; Molina J; Villate S; Umland O; Skyler JS; Bayer AL; Ricordi C; Pileggi A. 2012. Prevention of autoimmune diabetes and induction of beta-cell proliferation in NOD mice by hyperbaric oxygen therapy.. In: . . MGI: J:203601
Fang R; Ismail N; Walker DH. 2012. Contribution of NK cells to the innate phase of host protection against an intracellular bacterium targeting systemic endothelium.. In: . . MGI: J:185539
Farini A; Meregalli M; Belicchi M; Battistelli M; Parolini D; D'Antona G; Gavina M; Ottoboni L; Constantin G; Bottinelli R; Torrente Y. 2007. T and B lymphocyte depletion has a marked effect on the fibrosis of dystrophic skeletal muscles in the scid/mdx mouse.. In: . . MGI: J:125527
Farini A; Sitzia C; Navarro C; D'Antona G; Belicchi M; Parolini D; Del Fraro G; Razini P; Bottinelli R; Meregalli M; Torrente Y. 2012. Absence of T and B lymphocytes modulates dystrophic features in dysferlin deficient animal model.. In: . . MGI: J:186460
Fattahi F; Steinbeck JA; Kriks S; Tchieu J; Zimmer B; Kishinevsky S; Zeltner N; Mica Y; El-Nachef W; Zhao H; de Stanchina E; Gershon MD; Grikscheit TC; Chen S; Studer L. 2016. Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease.. In: . . MGI: J:229669
Feng M; Chen JY; Weissman-Tsukamoto R; Volkmer JP; Ho PY; McKenna KM; Cheshier S; Zhang M; Guo N; Gip P; Mitra SS; Weissman IL. 2015. Macrophages eat cancer cells using their own calreticulin as a guide: roles of TLR and Btk.. In: . . MGI: J:220007
Fernandez NC; Lozier A; Flament C; Ricciardi-Castagnoli P; Bellet D; Suter M; Perricaudet M; Tursz T; Maraskovsky E; Zitvogel L. 1999. Dendritic cells directly trigger NK cell functions: cross-talk relevant in innate anti-tumor immune responses in vivo.. In: . . MGI: J:54135
Fiorucci S; Mencarelli A; Palazzetti B; Sprague AG; Distrutti E; Morelli A; Novobrantseva TI; Cirino G; Koteliansky VE; de Fougerolles AR. 2002. Importance of innate immunity and collagen binding integrin alpha1beta1 in TNBS-induced colitis.. In: . . MGI: J:113581
Flanagan K; Modrusan Z; Cornelius J; Chavali A; Kasman I; Komuves L; Mo L; Diehl L. 2008. Intestinal Epithelial Cell Up-Regulation of LY6 Molecules during Colitis Results in Enhanced Chemokine Secretion.. In: . . MGI: J:133031
Flesken-Nikitin A; Hwang CI; Cheng CY; Michurina TV; Enikolopov G; Nikitin AY. 2013. Ovarian surface epithelium at the junction area contains a cancer-prone stem cell niche.. In: . . MGI: J:194916
Fogler WE; Volker K; Watanabe M; Wigginton JM; Roessler P; Brunda MJ; Ortaldo JR; Wiltrout RH. 1998. Recruitment of hepatic NK cells by IL-12 is dependent on IFN-gamma and VCAM-1 and is rapidly down-regulated by a mechanism involving T cells and expression of Fas.. In: . . MGI: J:115033
Foquet L; Hermsen CC; van Gemert GJ; Van Braeckel E; Weening KE; Sauerwein R; Meuleman P; Leroux-Roels G. 2014. Vaccine-induced monoclonal antibodies targeting circumsporozoite protein prevent Plasmodium falciparum infection.. In: . . MGI: J:207925
Forbes JM; Soderlund J; Yap FY; Knip M; Andrikopoulos S; Ilonen J; Simell O; Veijola R; Sourris KC; Coughlan MT; Forsblom C; Slattery R; Grey ST; Wessman M; Yamamoto H; Bierhaus A; Cooper ME; Groop PH. 2011. Receptor for advanced glycation end-products (RAGE) provides a link between genetic susceptibility and environmental factors in type 1 diabetes.. In: . . MGI: J:169600
Ford ML; Evavold BD. 2006. Modulation of MOG 37-50-specific CD8+ T cell activation and expansion by CD43.. In: . . MGI: J:112761
Fortner KA; Lees RK; Macdonald HR; Budd RC. 2011. Fas (CD95/APO-1) limits the expansion of T lymphocytes in an environment of limited T-cell antigen receptor/MHC contacts.. In: . . MGI: J:168554
Fournier B; Murray B; Gutzwiller S; Marcaletti S; Marcellin D; Bergling S; Brachat S; Persohn E; Pierrel E; Bombard F; Hatakeyama S; Trendelenburg AU; Morvan F; Richardson B; Glass DJ; Lach-Trifilieff E; Feige JN. 2012. Blockade of the activin receptor IIb activates functional brown adipogenesis and thermogenesis by inducing mitochondrial oxidative metabolism.. In: . . MGI: J:186659
Franco S; Murphy MM; Li G; Borjeson T; Boboila C; Alt FW. 2008. DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombination.. In: . . MGI: J:133132
Frese M; Lee E; Larena M; Lim PS; Rao S; Matthaei KI; Khromykh A; Ramshaw I; Lobigs M. 2014. Internal ribosome entry site-based attenuation of a flavivirus candidate vaccine and evaluation of the effect of Beta interferon coexpression on vaccine properties.. In: . . MGI: J:205265
Friedline RH; Ko HJ; Jung DY; Lee Y; Bortell R; Dagdeviren S; Patel PR; Hu X; Inashima K; Kearns C; Tsitsilianos N; Shafiq U; Shultz LD; Lee KW; Greiner DL; Kim JK. 2016. Genetic ablation of lymphocytes and cytokine signaling in nonobese diabetic mice prevents diet-induced obesity and insulin resistance.. In: . . MGI: J:230896
Friswell MK; Gika H; Stratford IJ; Theodoridis G; Telfer B; Wilson ID; McBain AJ. 2010. Site and strain-specific variation in gut microbiota profiles and metabolism in experimental mice.. In: . . MGI: J:157249
Fuentes RE; Zaitsev S; Ahn HS; Hayes V; Kowalska MA; Lambert MP; Wang Y; Siegel DL; Bougie DW; Aster RH; Myers DD; Stepanova V; Cines DB; Muzykantov VR; Poncz M. 2015. A chimeric platelet-targeted urokinase prodrug selectively blocks new thrombus formation.. In: . . MGI: J:231183
Fukunaga-Kalabis M; Martinez G; Nguyen TK; Kim D; Santiago-Walker A; Roesch A; Herlyn M. 2010. Tenascin-C promotes melanoma progression by maintaining the ABCB5-positive side population.. In: . . MGI: J:166563
Fulop GM; Phillips RA. 1986. Full reconstitution of the immune deficiency in scid mice with normal stem cells requires low-dose irradiation of the recipients.. In: . . MGI: J:8299
Fyfe AI; Qiao JH; Lusis AJ. 1994. Immune-deficient mice develop typical atherosclerotic fatty streaks when fed an atherogenic diet.. In: . . MGI: J:22138
Gallo-Hendrikx E; Percy D; Copps J; McKeown B; Quinton M; McMillan I; Croy BA; Wildeman AG. 1999. Evaluation of three lines of immunodeficient mice for the study of spontaneous metastatic tumors.. In: . . MGI: J:54114
Ganley L; Babu S; Rajan TV. 2001. Course of Brugia malayi infection in C57BL/6J NOS2 +/+ and -/- mice.. In: . . MGI: J:102684
Garcia-Barros M; Thin TH; Maj J; Cordon-Cardo C; Haimovitz-Friedman A; Fuks Z; Kolesnick R. 2010. Impact of stromal sensitivity on radiation response of tumors implanted in SCID hosts revisited.. In: . . MGI: J:165564
Garcia-Rivera MF; Colvin-Wanshura LE; Nelson MS; Nan Z; Khan SA; Rogers TB; Maitra I; Low WC; Gupta P. 2007. Characterization of an immunodeficient mouse model of mucopolysaccharidosis type I suitable for preclinical testing of human stem cell and gene therapy.. In: . . MGI: J:139626
Gawronska-Kozak B; Bogacki M; Rim JS; Monroe WT; Manuel JA. 2006. Scarless skin repair in immunodeficient mice.. In: . . MGI: J:135709
Gelman AE; LaRosa DF; Zhang J; Walsh PT; Choi Y; Sunyer JO; Turka LA. 2006. The adaptor molecule MyD88 activates PI-3 kinase signaling in CD4+ T cells and enables CpG oligodeoxynucleotide-mediated costimulation.. In: . . MGI: J:116106
Gerling IC; Friedman H; Greiner DL; Shultz LD; Leiter EH. 1994. Multiple low-dose streptozocin-induced diabetes in NOD-scid/scid mice in the absence of functional lymphocytes.. In: . . MGI: J:16998
Gesina E; Blondeau B; Milet A; Le Nin I; Duchene B; Czernichow P; Scharfmann R; Tronche F; Breant B. 2006. Glucocorticoid signalling affects pancreatic development through both direct and indirect effects.. In: . . MGI: J:147261
Gittens JE; Barr KJ; Vanderhyden BC; Kidder GM. 2005. Interplay between paracrine signaling and gap junctional communication in ovarian follicles.. In: . . MGI: J:94692
Gladdy RA; Nutter LM; Kunath T; Danska JS; Guidos CJ. 2006. p53-Independent apoptosis disrupts early organogenesis in embryos lacking both ataxia-telangiectasia mutated and Prkdc.. In: . . MGI: J:108789
Gladdy RA; Taylor MD; Williams CJ; Grandal I; Karaskova J; Squire JA; Rutka JT; Guidos CJ; Danska JS. 2003. The RAG-1/2 endonuclease causes genomic instability and controls CNS complications of lymphoblastic leukemia in p53/Prkdc-deficient mice.. In: . . MGI: J:81538
Glimm H; Eisterer W; Lee K; Cashman J; Holyoake TL; Nicolini F; Shultz LD; von Kalle C; Eaves CJ. 2001. Previously undetected human hematopoietic cell populations with short-term repopulating activity selectively engraft NOD/SCID-beta2 microglobulin-null mice.. In: . . MGI: J:66974
Goldstein AS; Huang J; Guo C; Garraway IP; Witte ON. 2010. Identification of a cell of origin for human prostate cancer.. In: . . MGI: J:162606
Gorantla S; Makarov E; Finke-Dwyer J; Gebhart CL; Domm W; Dewhurst S; Gendelman HE; Poluektova LY. 2010. CD8+ cell depletion accelerates HIV-1 immunopathology in humanized mice.. In: . . MGI: J:161304
Graff RJ. 1970. Polymorphism of histocompatibility genes in the mouse.. In: . . MGI: J:5237
Graser RT; DiLorenzo TP; Wang F; Christianson GJ; Chapman HD; Roopenian DC; Nathenson SG; Serreze DV. 2000. Identification of a CD8 T cell that can independently mediate autoimmune diabetes development in the complete absence of CD4 T cell helper functions.. In: . . MGI: J:93553
Gray CA; Lawrence RA. 2002. A role for antibody and Fc receptor in the clearance of Brugia malayi microfilariae.. In: . . MGI: J:115364
Green-Mitchell SM; Tersey SA; Cole BK; Ma K; Kuhn NS; Cunningham TD; Maybee NA; Chakrabarti SK; McDuffie M; Taylor-Fishwick DA; Mirmira RG; Nadler JL; Morris MA. 2013. Deletion of 12/15-lipoxygenase alters macrophage and islet function in NOD-Alox15(null) mice, leading to protection against type 1 diabetes development.. In: . . MGI: J:197192
Grenningloh R; Kang BY; Ho IC. 2005. Ets-1, a functional cofactor of T-bet, is essential for Th1 inflammatory responses.. In: . . MGI: J:96627
Griffin RL; Kupper TS; Divito SJ. 2015. Humanized Mice in Dermatology Research.. In: . . MGI: J:228055
Guay HM; Andreyeva TA; Garcea RL; Welsh RM; Szomolanyi-Tsuda E. 2007. MyD88 is required for the formation of long-term humoral immunity to virus infection.. In: . . MGI: J:145278
Guay HM; Panarey L; Reed AJ; Caton AJ. 2004. Specificity-based negative selection of autoreactive B cells during memory formation.. In: . . MGI: J:93744
Guidos CJ; Williams CJ; Grandal I; Knowles G; Huang MT; Danska JS. 1996. V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors.. In: . . MGI: J:102044
Gundry MC; Brunetti L; Lin A; Mayle AE; Kitano A; Wagner D; Hsu JI; Hoegenauer KA; Rooney CM; Goodell MA; Nakada D. 2016. Highly Efficient Genome Editing of Murine and Human Hematopoietic Progenitor Cells by CRISPR/Cas9.. In: . . MGI: J:240901
Gurley KE; Kemp CJ. 2001. Synthetic lethality between mutation in Atm and DNA-PK(cs) during murine embryogenesis.. In: . . MGI: J:67533
Gurley KE; Vo K; Kemp CJ. 1998. DNA double-strand breaks, p53, and apoptosis during lymphomagenesis in scid/scid mice.. In: . . MGI: J:49372
Haetscher N; Feuermann Y; Wingert S; Rehage M; Thalheimer FB; Weiser C; Bohnenberger H; Jung K; Schroeder T; Serve H; Oellerich T; Hennighausen L; Rieger MA. 2015. STAT5-regulated microRNA-193b controls haematopoietic stem and progenitor cell expansion by modulating cytokine receptor signalling.. In: . . MGI: J:228007
Haks MC; Belkowski SM; Ciofani M; Rhodes M; Lefebvre JM; Trop S; Hugo P; Zuniga-Pflucker JC; Wiest DL. 2003. Low activation threshold as a mechanism for ligand-independent signaling in pre-T cells.. In: . . MGI: J:126301
Haks MC; Krimpenfort P; van den Brakel JH; Kruisbeek AM. 1999. Pre-TCR signaling and inactivation of p53 induces crucial cell survival pathways in pre-T cells.. In: . . MGI: J:110456
Halim TY; Maclaren A; Romanish MT; Gold MJ; McNagny KM; Takei F. 2012. Retinoic-Acid-receptor-related orphan nuclear receptor alpha is required for natural helper cell development and allergic inflammation.. In: . . MGI: J:187662
Halin C; Tobler NE; Vigl B; Brown LF; Detmar M. 2007. VEGF-A produced by chronically inflamed tissue induces lymphangiogenesis in draining lymph nodes.. In: . . MGI: J:148904
Haller BL; Barkon ML; Vogler GP; Virgin HW 4th. 1995. Genetic mapping of reovirus virulence and organ tropism in severe combined immunodeficient mice: organ-specific virulence genes.. In: . . MGI: J:21933
Han D; Walsh MC; Cejas PJ; Dang NN; Kim YF; Kim J; Charrier-Hisamuddin L; Chau L; Zhang Q; Bittinger K; Bushman FD; Turka LA; Shen H; Reizis B; Defranco AL; Wu GD; Choi Y. 2013. Dendritic cell expression of the signaling molecule TRAF6 is critical for gut microbiota-dependent immune tolerance.. In: . . MGI: J:207581
Han SJ; Jung SY; Wu SP; Hawkins SM; Park MJ; Kyo S; Qin J; Lydon JP; Tsai SY; Tsai MJ; DeMayo FJ; O'Malley BW. 2015. Estrogen Receptor beta Modulates Apoptosis Complexes and the Inflammasome to Drive the Pathogenesis of Endometriosis.. In: . . MGI: J:228035
Hande P; Slijepcevic P; Silver A; Bouffler S; van Buul P; Bryant P ; Lansdorp P. 1999. Elongated telomeres in scid mice.. In: . . MGI: J:53579
Hanks BA; Holtzhausen A; Evans KS; Jamieson R; Gimpel P; Campbell OM; Hector-Greene M; Sun L; Tewari A; George A; Starr M; Nixon A; Augustine C; Beasley G; Tyler DS; Osada T; Morse MA; Ling L; Lyerly HK; Blobe GC. 2013. Type III TGF-beta receptor downregulation generates an immunotolerant tumor microenvironment.. In: . . MGI: J:201617
Harkness RE; Guimond MJ; McBey BA; Klein MH; Percy DH; Croy BA. 1993. Branhamella catarrhalis pathogenesis in SCID and SCID/beige mice. Brief report.. In: . . MGI: J:16050
Harris WJ; Huang X; Lynch JT; Spencer GJ; Hitchin JR; Li Y; Ciceri F; Blaser JG; Greystoke BF; Jordan AM; Miller CJ; Ogilvie DJ; Somervaille TC. 2012. The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells.. In: . . MGI: J:189339
Hasegawa M; Kawai K; Mitsui T; Taniguchi K; Monnai M; Wakui M; Ito M; Suematsu M; Peltz G; Nakamura M; Suemizu H. 2011. The reconstituted 'humanized liver' in TK-NOG mice is mature and functional.. In: . . MGI: J:170638
Hastey CJ; Elsner RA; Barthold SW; Baumgarth N. 2012. Delays and diversions mark the development of B cell responses to Borrelia burgdorferi infection.. In: . . MGI: J:188726
Hayakawa Y; Sakitani K; Konishi M; Asfaha S; Niikura R; Tomita H; Renz BW; Tailor Y; Macchini M; Middelhoff M; Jiang Z; Tanaka T; Dubeykovskaya ZA; Kim W; Chen X; Urbanska AM; Nagar K; Westphalen CB; Quante M; Lin CS; Gershon MD; Hara A; Zhao CM; Chen D; Worthley DL; Koike K; Wang TC. 2017. Nerve Growth Factor Promotes Gastric Tumorigenesis through Aberrant Cholinergic Signaling.. In: . . MGI: J:238420
Hayashi Y; Haneji N; Hamano H; Yanagi K. 1994. Transfer of Sjogren's syndrome-like autoimmune lesions into SCID mice and prevention of lesions by anti-CD4 and anti-T cell receptor antibody treatment.. In: . . MGI: J:21965
Hayward AR; Chmura K; Cosyns M. 2000. Interferon-gamma is required for innate immunity to Cryptosporidium parvum in mice.. In: . . MGI: J:125986
He J; Haskins K. 2008. Pathogenicity of T helper 2 T-cell clones from T-cell receptor transgenic non-obese diabetic mice is determined by tumour necrosis factor-alpha.. In: . . MGI: J:134900
He Q; Morillon YM 2nd; Spidale NA; Kroger CJ; Liu B; Sartor RB; Wang B; Tisch R. 2013. Thymic development of autoreactive T cells in NOD mice is regulated in an age-dependent manner.. In: . . MGI: J:207147
Heaney NB; Pellicano F; Zhang B; Crawford L; Chu S; Kazmi SM; Allan EK; Jorgensen HG; Irvine AE; Bhatia R; Holyoake TL. 2010. Bortezomib induces apoptosis in primitive chronic myeloid leukemia cells including LTC-IC and NOD/SCID repopulating cells.. In: . . MGI: J:162612
Heine D; Passmore HC; Patel V; Shultz LD; Ward-Bailey P; Cook SA; Davisson MT. 1996. Effect of the mouse scid mutation on meiotic recombination.. In: . . MGI: J:34473
Hernandez-Novoa B; Bishop L; Logun C; Munson PJ; Elnekave E; Rangel ZG; Barb J; Danner RL; Kovacs JA. 2008. Immune responses to Pneumocystis murina are robust in healthy mice but largely absent in CD40 ligand-deficient mice.. In: . . MGI: J:138448
Hertz CJ; Filutowicz H; Mansfield JM. 1998. Resistance to the African trypanosomes is IFN-gamma dependent.. In: . . MGI: J:115095
Hesselton RM; Greiner DL; Mordes JP; Rajan TV; Sullivan JL; Shultz LD. 1995. High levels of human peripheral blood mononuclear cell engraftment and enhanced susceptibility to human immunodeficiency virus type 1 infection in NOD/LtSz-scid/scid mice.. In: . . MGI: J:109911
Hettmer S; Liu J; Miller CM; Lindsay MC; Sparks CA; Guertin DA; Bronson RT; Langenau DM; Wagers AJ. 2011. Sarcomas induced in discrete subsets of prospectively isolated skeletal muscle cells.. In: . . MGI: J:180528
Hilbert DM; Anderson AO; Holmes KL; Rudikoff S. 1994. Long-term lymphoid reconstitution of SCID mice suggests self-renewing B and T cell populations in peripheral and mucosal tissues.. In: . . MGI: J:19983
Hioki K; Kuramochi T; Endoh S; Terada E; Ueyama Y; Ito M. 2001. Lack of B cell leakiness in BALB/cA-nu, scid double mutant mice.. In: . . MGI: J:68089
Hirai H; Verma M; Watanabe S; Tastad C; Asakura Y; Asakura A. 2010. MyoD regulates apoptosis of myoblasts through microRNA-mediated down-regulation of Pax3.. In: . . MGI: J:165481
Hiramatsu H; Nishikomori R; Heike T; Ito M; Kobayashi K; Katamura K; Nakahata T. 2003. Complete reconstitution of human lymphocytes from cord blood CD34+ cells using the NOD/SCID/gammacnull mice model.. In: . . MGI: J:163372
Hofling AA; Vogler C; Creer MH; Sands MS. 2003. Engraftment of human CD34+ cells leads to widespread distribution of donor-derived cells and correction of tissue pathology in a novel murine xenotransplantation model of lysosomal storage disease.. In: . . MGI: J:109848
Hoggatt J; Singh P; Sampath J; Pelus LM. 2009. Prostaglandin E2 enhances hematopoietic stem cell homing, survival, and proliferation.. In: . . MGI: J:148898
Holland JD; Gyorffy B; Vogel R; Eckert K; Valenti G; Fang L; Lohneis P; Elezkurtaj S; Ziebold U; Birchmeier W. 2013. Combined Wnt/beta-catenin, Met, and CXCL12/CXCR4 signals characterize basal breast cancer and predict disease outcome.. In: . . MGI: J:206839
Holm TM; Jackson-Grusby L; Brambrink T; Yamada Y; Rideout WM 3rd; Jaenisch R. 2005. Global loss of imprinting leads to widespread tumorigenesis in adult mice.. In: . . MGI: J:104860
Holodick NE; Vizconde T; Rothstein TL. 2014. B-1a cell diversity: nontemplated addition in B-1a cell Ig is determined by progenitor population and developmental location.. In: . . MGI: J:209818
Holopainen T; Saharinen P; D'Amico G; Lampinen A; Eklund L; Sormunen R; Anisimov A; Zarkada G; Lohela M; Helotera H; Tammela T; Benjamin LE; Yla-Herttuala S; Leow CC; Koh GY; Alitalo K. 2012. Effects of angiopoietin-2-blocking antibody on endothelial cell-cell junctions and lung metastasis.. In: . . MGI: J:184937
Holt N; Wang J; Kim K; Friedman G; Wang X; Taupin V; Crooks GM; Kohn DB; Gregory PD; Holmes MC; Cannon PM. 2010. Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo.. In: . . MGI: J:162607
Hontecillas R; Bassaganya-Riera J. 2007. Peroxisome proliferator-activated receptor gamma is required for regulatory CD4+ T cell-mediated protection against colitis.. In: . . MGI: J:144105
Horai R; Nakajima A; Habiro K; Kotani M; Nakae S; Matsuki T; Nambu A; Saijo S; Kotaki H; Sudo K; Okahara A; Tanioka H; Ikuse T; Ishii N; Schwartzberg PL; Abe R; Iwakura Y. 2004. TNF-alpha is crucial for the development of autoimmune arthritis in IL-1 receptor antagonist-deficient mice.. In: . . MGI: J:94429
Hoshino T; Winkler-Pickett RT; Mason AT; Ortaldo JR; Young HA. 1999. IL-13 production by NK cells: IL-13-producing NK and T cells are present in vivo in the absence of IFN-gamma.. In: . . MGI: J:112424
Houghtaling S; Newell A; Akkari Y; Taniguchi T; Olson S; Grompe M. 2005. Fancd2 functions in a double strand break repair pathway that is distinct from non-homologous end joining.. In: . . MGI: J:102754
Hsu DM; Agarwal S; Benham A; Coarfa C; Trahan DN; Chen Z; Stowers PN; Courtney AN; Lakoma A; Barbieri E; Metelitsa LS; Gunaratne P; Kim ES; Shohet JM. 2013. G-CSF Receptor Positive Neuroblastoma Subpopulations Are Enriched in Chemotherapy-Resistant or Relapsed Tumors and Are Highly Tumorigenic.. In: . . MGI: J:199119
Hu Z; Van Rooijen N; Yang YG. 2011. Macrophages prevent human red blood cell reconstitution in immunodeficient mice.. In: . . MGI: J:178783
Hua C; Chang B; Ma B-L; Li Y; Wang G. 1992. Reduction of lymphokine-activated killer cell activity by the introduction of the beige gene into SCID mice. In: . . MGI: J:2627
Huang P; Huo Y; Lou LX; Li H; Barnstable CJ; Zhang C; Zhang SS. 2013. CD4 positive T helper cells contribute to retinal ganglion cell death in mouse model of ischemia reperfusion injury.. In: . . MGI: J:210412
Hubner A; Mulholland DJ; Standen CL; Karasarides M; Cavanagh-Kyros J; Barrett T; Chi H; Greiner DL; Tournier C; Sawyers CL; Flavell RA; Wu H; Davis RJ. 2012. JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate.. In: . . MGI: J:186492
Hubner MP; Shi Y; Torrero MN; Mueller E; Larson D; Soloviova K; Gondorf F; Hoerauf A; Killoran KE; Stocker JT; Davies SJ; Tarbell KV; Mitre E. 2012. Helminth protection against autoimmune diabetes in nonobese diabetic mice is independent of a type 2 immune shift and requires TGF-beta.. In: . . MGI: J:180789
Hugues S; Mougneau E; Ferlin W; Jeske D; Hofman P; Homann D; Beaudoin L; Schrike C; Von Herrath M; Lehuen A; Glaichenhaus N. 2002. Tolerance to islet antigens and prevention from diabetes induced by limited apoptosis of pancreatic beta cells.. In: . . MGI: J:132052
Hull ML; Johan MZ; Hodge WL; Robertson SA; Ingman WV. 2012. Host-derived TGFB1 deficiency suppresses lesion development in a mouse model of endometriosis.. In: . . MGI: J:181959
Hunter CA; Ellis-Neyes LA; Slifer T; Kanaly S; Grunig G; Fort M; Rennick D; Araujo FG. 1997. IL-10 is required to prevent immune hyperactivity during infection with Trypanosoma cruzi.. In: . . MGI: J:110835
Ichimura Y; Waguri S; Sou YS; Kageyama S; Hasegawa J; Ishimura R; Saito T; Yang Y; Kouno T; Fukutomi T; Hoshii T; Hirao A; Takagi K; Mizushima T; Motohashi H; Lee MS; Yoshimori T; Tanaka K; Yamamoto M; Komatsu M. 2013. Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.. In: . . MGI: J:203811
Ingman WV; Robertson SA. 2008. Mammary gland development in transforming growth factor beta1 null mutant mice: systemic and epithelial effects.. In: . . MGI: J:140882
Ingman WV; Robertson SA. 2007. Transforming growth factor-beta1 null mutation causes infertility in male mice associated with testosterone deficiency and sexual dysfunction.. In: . . MGI: J:129629
Ingman WV; Robker RL; Woittiez K; Robertson SA. 2006. Null mutation in transforming growth factor beta1 disrupts ovarian function and causes oocyte incompetence and early embryo arrest.. In: . . MGI: J:129446
Ippolito GC; Hoi KH; Reddy ST; Carroll SM; Ge X; Rogosch T; Zemlin M; Shultz LD; Ellington AD; Vandenberg CL; Georgiou G. 2012. Antibody repertoires in humanized NOD-scid-IL2Rgamma(null) mice and human B cells reveals human-like diversification and tolerance checkpoints in the mouse.. In: . . MGI: J:187283
Ishii T; Zhao Y; Sozer S; Shi J; Zhang W; Hoffman R; Xu M. 2007. Behavior of CD34+ cells isolated from patients with polycythemia vera in NOD/SCID mice.. In: . . MGI: J:132540
Ishii-Ohba H; Kobayashi S; Nishimura M; Shimada Y; Tsuji H; Sado T; Ogiu T. 2007. Existence of a threshold-like dose for gamma-ray induction of thymic lymphomas and no susceptibility to radiation-induced solid tumors in SCID mice.. In: . . MGI: J:120953
Ishikawa F; Yasukawa M; Lyons B; Yoshida S; Miyamoto T; Yoshimoto G; Watanabe T; Akashi K; Shultz LD; Harada M. 2005. Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) mice.. In: . . MGI: J:142411
Ito M; Hiramatsu H; Kobayashi K; Suzue K; Kawahata M; Hioki K; Ueyama Y; Koyanagi Y; Sugamura K; Tsuji K; Heike T; Nakahata T. 2002. NOD/SCID/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells.. In: . . MGI: J:163373
Ito R; Katano I; Ida-Tanaka M; Kamisako T; Kawai K; Suemizu H; Aiso S; Ito M. 2012. Efficient xenoengraftment in severe immunodeficient NOD/Shi-scid IL2rgammanull mice is attributed to a lack of CD11c+B220+CD122+ cells.. In: . . MGI: J:190612
Ito R; Negishi N; Irie N; Matsuo K; Suzuki D; Katano I; Hayakawa E; Kawai K; Kamisako T; Eto T; Ogura T; Hozumi K; Ando K; Aiso S; Tamaoki N; Habu S; Ito M. 2012. Osteosclerosis and inhibition of human hematopoiesis in NOG mice expressing human Delta-like 1 in osteoblasts.. In: . . MGI: J:203591
Ito R; Takahashi T; Katano I; Kawai K; Kamisako T; Ogura T; Ida-Tanaka M; Suemizu H; Nunomura S; Ra C; Mori A; Aiso S; Ito M. 2013. Establishment of a human allergy model using human IL-3/GM-CSF-transgenic NOG mice.. In: . . MGI: J:205873
Ito T; Seyama T; Kyoizumi S; Teraoka S; Iwamoto KS; Mizuno T; Tsuyama N; Asahara T; Dohi K; Akiyama M. 1995. The usefulness of severe combined immunodeficiency (SCID) mice to study human carcinogenesis.. In: . . MGI: J:23712
Iwai H; Abe M; Hirose S; Tsushima F; Tezuka K; Akiba H; Yagita H; Okumura K; Kohsaka H; Miyasaka N; Azuma M. 2003. Involvement of inducible costimulator-B7 homologous protein costimulatory pathway in murine lupus nephritis.. In: . . MGI: J:120381
Jaakkola I; Jalkanen S; Hanninen A. 2003. Diabetogenic T cells are primed both in pancreatic and gut-associated lymph nodes in NOD mice.. In: . . MGI: J:87142
Jaeschke A; Rincon M; Doran B; Reilly J; Neuberg D; Greiner DL; Shultz LD; Rossini AA; Flavell RA; Davis RJ. 2005. Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes.. In: . . MGI: J:99056
Jahchan NS; Lim JS; Bola B; Morris K; Seitz G; Tran KQ; Xu L; Trapani F; Morrow CJ; Cristea S; Coles GL; Yang D; Vaka D; Kareta MS; George J; Mazur PK; Nguyen T; Anderson WC; Dylla SJ; Blackhall F; Peifer M; Dive C; Sage J. 2016. Identification and Targeting of Long-Term Tumor-Propagating Cells in Small Cell Lung Cancer.. In: . . MGI: J:238584
Jaiswal S; Pearson T; Friberg H; Shultz LD; Greiner DL; Rothman AL; Mathew A. 2009. Dengue virus infection and virus-specific HLA-A2 restricted immune responses in humanized NOD-scid IL2rgammanull mice.. In: . . MGI: J:154110
Janes MR; Limon JJ; So L; Chen J; Lim RJ; Chavez MA; Vu C; Lilly MB; Mallya S; Ong ST; Konopleva M; Martin MB; Ren P; Liu Y; Rommel C; Fruman DA. 2010. Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor.. In: . . MGI: J:162611
Jimenez de Bagues MP; de Martino A; Quintana JF; Alcaraz A; Pardo J. 2011. Course of Infection with the Emergent Pathogen Brucella microti in Immunocompromised Mice.. In: . . MGI: J:175995
Johnson RM; Papp E; Grandal I; Kowalski PE; Nutter L; Wong RC; Joseph-George AM; Danska JS; Guidos CJ. 2014. MuLV-related endogenous retroviral elements and Flt3 participate in aberrant end-joining events that promote B-cell leukemogenesis.. In: . . MGI: J:211638
Jones-Carson J; Vazquez-Torres A; Balish E. 1995. Defective killing of Candida albicans hyphae by neutrophils from beige mice.. In: . . MGI: J:25930
Juelke K; Killig M; Luetke-Eversloh M; Parente E; Gruen J; Morandi B; Ferlazzo G; Thiel A; Schmitt-Knosalla I; Romagnani C. 2010. CD62L expression identifies a unique subset of polyfunctional CD56dim NK cells.. In: . . MGI: J:163485
Jun HS; Santamaria P; Lim HW; Zhang ML; Yoon JW. 1999. Absolute requirement of macrophages for the development and activation of beta-cell cytotoxic CD8+ T-cells in T-cell receptor transgenic NOD mice.. In: . . MGI: J:108751
Kagari T; Doi H; Shimozato T. 2002. The importance of IL-1 beta and TNF-alpha, and the noninvolvement of IL-6, in the development of monoclonal antibody-induced arthritis.. In: . . MGI: J:120707
Kahiri CN; Khalil MW; Tekpetey F; Kidder GM. 2006. Leydig cell function in mice lacking connexin43.. In: . . MGI: J:112888
Kalaany NY; Sabatini DM. 2009. Tumours with PI3K activation are resistant to dietary restriction.. In: . . MGI: J:147281
Kalscheuer H; Onoe T; Dahmani A; Li HW; Holzl M; Yamada K; Sykes M. 2014. Xenograft tolerance and immune function of human T cells developing in pig thymus xenografts.. In: . . MGI: J:209878
Kariya R; Taura M; Suzu S; Kai H; Katano H; Okada S. 2014. HIV protease inhibitor Lopinavir induces apoptosis of primary effusion lymphoma cells via suppression of NF-kappaB pathway.. In: . . MGI: J:204517
Katakura K; Lee J; Rachmilewitz D; Li G; Eckmann L; Raz E. 2005. Toll-like receptor 9-induced type I IFN protects mice from experimental colitis.. In: . . MGI: J:110027
Katakura T; Yoshida T; Kobayashi M; Herndon DN; Suzuki F. 2005. Immunological control of methicillin-resistant Staphylococcus aureus (MRSA) infection in an immunodeficient murine model of thermal injuries.. In: . . MGI: J:107603
Kawaguchi-Miyashita M; Shimada S; Kurosu H; Kato-Nagaoka N; Matsuoka Y; Ohwaki M; Ishikawa H; Nanno M. 2001. An accessory role of TCRgammadelta (+) cells in the exacerbation of inflammatory bowel disease in TCRalpha mutant mice.. In: . . MGI: J:68810
Kawahara M; Pandolfi A; Bartholdy B; Barreyro L; Will B; Roth M; Okoye-Okafor UC; Todorova TI; Figueroa ME; Melnick A; Mitsiades CS; Steidl U. 2012. H2.0-like homeobox regulates early hematopoiesis and promotes acute myeloid leukemia.. In: . . MGI: J:191823
Kayama H; Ueda Y; Sawa Y; Jeon SG; Ma JS; Okumura R; Kubo A; Ishii M; Okazaki T; Murakami M; Yamamoto M; Yagita H; Takeda K. 2012. Intestinal CX3C chemokine receptor 1high (CX3CR1high) myeloid cells prevent T-cell-dependent colitis.. In: . . MGI: J:182225
Kazerounian S; Gerald D; Huang M; Chin YR; Udayakumar D; Zheng N; O'Donnell RK; Perruzzi C; Mangiante L; Pourat J; Phung TL; Bravo-Nuevo A; Shechter S; McNamara S; Duhadaway JB; Kocher ON; Brown LF; Toker A; Prendergast GC; Benjamin LE. 2013. RhoB differentially controls Akt function in tumor cells and stromal endothelial cells during breast tumorigenesis.. In: . . MGI: J:194113
Kelly MN; Zheng M; Ruan S; Kolls J; D'Souza A; Shellito JE. 2013. Memory CD4+ T Cells Are Required for Optimal NK Cell Effector Functions against the Opportunistic Fungal Pathogen Pneumocystis murina.. In: . . MGI: J:190830
Kemp CJ; Vo K; Gurley KE. 1999. Resistance to skin tumorigenesis in DNAPK-deficient SCID mice is not due to immunodeficiency but results from hypersensitivity to TPA-induced apoptosis.. In: . . MGI: J:58425
Khaled AR; Li WQ; Huang J; Fry TJ; Khaled AS; Mackall CL; Muegge K; Young HA; Durum SK. 2002. Bax deficiency partially corrects interleukin-7 receptor alpha deficiency.. In: . . MGI: J:93139
Kharbanda S; Pandey P; Jin S; Inoue S; Bharti A; Yuan ZM; Weichselbaum R; Weaver D; Kufe D. 1997. Functional interaction between DNA-PK and c-Abl in response to DNA damage.. In: . . MGI: J:116399
Kiaris H; Chatzistamou I; Trimis G; Frangou-Plemmenou M; Pafiti-Kondi A; Kalofoutis A. 2005. Evidence for nonautonomous effect of p53 tumor suppressor in carcinogenesis.. In: . . MGI: J:97031
Kiefer K; Nakajima PB; Oshinsky J; Seeholzer SH; Radic M; Bosma GC; Bosma MJ. 2008. Antigen receptor editing in anti-DNA transitional B cells deficient for surface IgM.. In: . . MGI: J:160356
Kiefer K; Oshinsky J; Kim J; Nakajima PB; Bosma GC; Bosma MJ. 2007. The catalytic subunit of DNA-protein kinase (DNA-PKcs) is not required for Ig class-switch recombination.. In: . . MGI: J:125895
Kim KD; Srikanth S; Yee MK; Mock DC; Lawson GW; Gwack Y. 2011. ORAI1 deficiency impairs activated T cell death and enhances T cell survival.. In: . . MGI: J:179333
Kim S; Dubrovska A; Salamone RJ; Walker JR; Grandinetti KB; Bonamy GM; Orth AP; Elliott J; Porta DG; Garcia-Echeverria C; Reddy VA. 2013. FGFR2 promotes breast tumorigenicity through maintenance of breast tumor-initiating cells.. In: . . MGI: J:195822
King MA; Covassin L; Brehm MA; Racki W; Pearson T; Leif J; Laning J; Fodor W; Foreman O; Burzenski L; Chase TH; Gott B; Rossini AA; Bortell R; Shultz LD; Greiner DL. 2009. Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex.. In: . . MGI: J:151390
Kinkel SA; Galeev R; Flensburg C; Keniry A; Breslin K; Gilan O; Lee S; Liu J; Chen K; Gearing LJ; Moore DL; Alexander WS; Dawson M; Majewski IJ; Oshlack A; Larsson J; Blewitt ME. 2015. Jarid2 regulates hematopoietic stem cell function by acting with polycomb repressive complex 2.. In: . . MGI: J:222052
Kitamura K; Nakamoto Y; Kaneko S; Mukaida N. 2004. Pivotal roles of interleukin-6 in transmural inflammation in murine T cell transfer colitis.. In: . . MGI: J:94173
Kitaura H; Zhou P; Kim HJ; Novack DV; Ross FP; Teitelbaum SL. 2005. M-CSF mediates TNF-induced inflammatory osteolysis.. In: . . MGI: J:104533
Klein MA; Frigg R; Flechsig E; Raeber AJ; Kalinke U; Bluethmann H; Bootz F; Suter M; Zinkernagel RM; Aguzzi A. 1997. A crucial role for B cells in neuroinvasive scrapie [see comments]. In: . . MGI: J:44933
Klug F; Prakash H; Huber PE; Seibel T; Bender N; Halama N; Pfirschke C; Voss RH; Timke C; Umansky L; Klapproth K; Schakel K; Garbi N; Jager D; Weitz J; Schmitz-Winnenthal H; Hammerling GJ; Beckhove P. 2013. Low-dose irradiation programs macrophage differentiation to an iNOS(+)/M1 phenotype that orchestrates effective T cell immunotherapy.. In: . . MGI: J:206743
Kobayashi M; Nakamura K; Cornforth M; Suzuki F. 2012. Role of M2b macrophages in the acceleration of bacterial translocation and subsequent sepsis in mice exposed to whole body [137Cs] gamma-irradiation.. In: . . MGI: J:188934
Kodama T; Hikita H; Kawaguchi T; Saito Y; Tanaka S; Shigekawa M; Shimizu S; Li W; Miyagi T; Kanto T; Hiramatsu N; Tatsumi T; Takehara T. 2013. The Bcl-2 homology domain 3 (BH3)-only proteins Bim and bid are functionally active and restrained by anti-apoptotic Bcl-2 family proteins in healthy liver.. In: . . MGI: J:203931
Kometani K; Aoki M; Kawamata S; Shinozuka Y; Era T; Taniwaki M; Hattori M; Minato N. 2006. Role of SPA-1 in phenotypes of chronic myelogenous leukemia induced by BCR-ABL-expressing hematopoietic progenitors in a mouse model.. In: . . MGI: J:114993
Kong L; Robinson CP; Peck AB; Vela-Roch N; Sakata KM; Dang H; Talal N; Humphreys-Beher MG. 1998. Inappropriate apoptosis of salivary and lacrimal gland epithelium of immunodeficient NOD-scid mice.. In: . . MGI: J:53650
Kota DJ; Wiggins LL; Yoon N; Lee RH. 2013. TSG-6 produced by hMSCs delays the onset of autoimmune diabetes by suppressing Th1 development and enhancing tolerogenicity.. In: . . MGI: J:208563
Krishnamurthy S; Warner KA; Dong Z; Imai A; Nor C; Ward BB; Helman JI; Taichman RS; Bellile EL; McCauley LK; Polverini PJ; Prince ME; Wicha MS; Nor JE. 2014. Endothelial interleukin-6 defines the tumorigenic potential of primary human cancer stem cells.. In: . . MGI: J:218558
Ksander BR; Kolovou PE; Wilson BJ; Saab KR; Guo Q; Ma J; McGuire SP; Gregory MS; Vincent WJ; Perez VL; Cruz-Guilloty F; Kao WW; Call MK; Tucker BA; Zhan Q; Murphy GF; Lathrop KL; Alt C; Mortensen LJ; Lin CP; Zieske JD; Frank MH; Frank NY. 2014. ABCB5 is a limbal stem cell gene required for corneal development and repair.. In: . . MGI: J:213708
Kumar P; Ban HS; Kim SS; Wu H; Pearson T; Greiner DL; Laouar A; Yao J; Haridas V; Habiro K; Yang YG; Jeong JH; Lee KY; Kim YH; Kim SW; Peipp M; Fey GH; Manjunath N; Shultz LD; Lee SK; Shankar P. 2008. T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice.. In: . . MGI: J:142409
Kunisawa J; Gohda M; Kurashima Y; Ishikawa I; Higuchi M; Kiyono H. 2008. Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NF{kappa}B-inducing kinase in stromal cells.. In: . . MGI: J:134340
Kupfer TM; Crawford ML; Pham K; Gill RG. 2005. MHC-mismatched islet allografts are vulnerable to autoimmune recognition in vivo.. In: . . MGI: J:107508
Kurkjian C; Hollifield M; Lines JL; Rogosky A; Empey KM; Qureshi M; Brown SA; Garvy BA. 2012. Alveolar Macrophages in Neonatal Mice Are Inherently Unresponsive to Pneumocystis murina Infection.. In: . . MGI: J:186637
Kwun J; Hu H; Schadde E; Roenneburg D; Sullivan KA; DeMartino J; Burlingham WJ; Knechtle SJ. 2007. Altered distribution of H60 minor H antigen-specific CD8 T cells and attenuated chronic vasculopathy in minor histocompatibility antigen mismatched heart transplantation in Cxcr3-/- mouse recipients.. In: . . MGI: J:155042
Larcher F; Del Rio M; Serrano F; Segovia JC; Ramirez A; Meana A; Page A; Abad JL; Gonzalez MA; Bueren J; Bernad A; Jorcano JL. 2001. A cutaneous gene therapy approach to human leptin deficiencies: correction of the murine ob/ob phenotype using leptin-targeted keratinocyte grafts.. In: . . MGI: J:115148
Law KM; Komarova NL; Yewdall AW; Lee RK; Herrera OL; Wodarz D; Chen BK. 2016. In Vivo HIV-1 Cell-to-Cell Transmission Promotes Multicopy Micro-compartmentalized Infection.. In: . . MGI: J:238305
Lawres LA; Garg A; Kumar V; Bruzual I; Forquer IP; Renard I; Virji AZ; Boulard P; Rodriguez EX; Allen AJ; Pou S; Wegmann KW; Winter RW; Nilsen A; Mao J; Preston DA; Belperron AA; Bockenstedt LK; Hinrichs DJ; Riscoe MK; Doggett JS; Ben Mamoun C. 2016. Radical cure of experimental babesiosis in immunodeficient mice using a combination of an endochin-like quinolone and atovaquone.. In: . . MGI: J:236267
Lazarus JJ; Meadows MJ; Lintner RE; Wooten RM. 2006. IL-10 deficiency promotes increased Borrelia burgdorferi clearance predominantly through enhanced innate immune responses.. In: . . MGI: J:140484
Lee HM; Wysoczynski M; Liu R; Shin DM; Kucia M; Botto M; Ratajczak J; Ratajczak MZ. 2010. Mobilization studies in complement-deficient mice reveal that optimal AMD3100 mobilization of hematopoietic stem cells depends on complement cascade activation by AMD3100-stimulated granulocytes.. In: . . MGI: J:158026
Lee SM; Yang H; Tartar DM; Gao B; Luo X; Ye SQ; Zaghouani H; Fang D. 2011. Prevention and treatment of diabetes with resveratrol in a non-obese mouse model of type 1 diabetes.. In: . . MGI: J:169586
Lefevre S; Knedla A; Tennie C; Kampmann A; Wunrau C; Dinser R; Korb A; Schnaker EM; Tarner IH; Robbins PD; Evans CH; Sturz H; Steinmeyer J; Gay S; Scholmerich J; Pap T; Muller-Ladner U; Neumann E. 2009. Synovial fibroblasts spread rheumatoid arthritis to unaffected joints.. In: . . MGI: J:155763
Leiter EH; Prochazka M; Shultz LD. 1987. Effect of immunodeficiency on diabetogenesis in genetically diabetic (db/db) mice.. In: . . MGI: J:32752
Leung J; Suh WK. 2013. Host B7-H4 regulates antitumor T cell responses through inhibition of myeloid-derived suppressor cells in a 4T1 tumor transplantation model.. In: . . MGI: J:204842
Li B; Sharpe EE; Maupin AB; Teleron AA; Pyle AL; Carmeliet P; Young PP. 2006. VEGF and PlGF promote adult vasculogenesis by enhancing EPC recruitment and vessel formation at the site of tumor neovascularization.. In: . . MGI: J:111344
Li CR; Mueller EE; Bradley LM. 2014. Islet antigen-specific Th17 cells can induce TNF-alpha-dependent autoimmune diabetes.. In: . . MGI: J:209355
Li E; Zhou P; Singer SM. 2006. Neuronal nitric oxide synthase is necessary for elimination of Giardia lamblia infections in mice.. In: . . MGI: J:126256
Li G; Zhang L; Chen E; Wang J; Jiang X; Chen JH; Wickman G; Amundson K; Bergqvist S; Zobel J; Buckman D; Baxi SM; Bender SL; Casperson GF; Hu-Lowe DD. 2010. Dual functional monoclonal antibody PF-04605412 targets integrin alpha5beta1 and elicits potent antibody-dependent cellular cytotoxicity.. In: . . MGI: J:167600
Li S; Ling C; Zhong L; Li M; Su Q; He R; Tang Q; Greiner DL; Shultz LD; Brehm MA; Flotte TR; Mueller C; Srivastava A; Gao G. 2015. Efficient and Targeted Transduction of Nonhuman Primate Liver With Systemically Delivered Optimized AAV3B Vectors.. In: . . MGI: J:230567
Li SW; Koya V; Li Y; Donelan W; Lin P; Reeves WH; Yang LJ. 2010. Pancreatic duodenal homeobox 1 protein is a novel beta-cell-specific autoantigen for type I diabetes.. In: . . MGI: J:156607
Li T; Ramirez K; Palacios R. 1996. Distinct patterns of Fas cell surface expression during development of T- or B-lymphocyte lineages in normal, scid, and mutant mice lacking or overexpressing p53, bcl-2, or rag-2 genes.. In: . . MGI: J:31364
Li X; Sterling JA; Fan KH; Vessella RL; Shyr Y; Hayward SW; Matrisian LM; Bhowmick NA. 2012. Loss of TGF-beta responsiveness in prostate stromal cells alters chemokine levels and facilitates the development of mixed osteoblastic/osteolytic bone lesions.. In: . . MGI: J:205394
Li Y; Su J; Dingzhang X; Zhang J; Yoshimoto M; Liu S; Bijian K; Gupta A; Squire JA; Alaoui Jamali MA; Bismar TA. 2011. PTEN deletion and heme oxygenase-1 overexpression cooperate in prostate cancer progression and are associated with adverse clinical outcome.. In: . . MGI: J:171247
Liao MJ; Zhang XX; Hill R; Gao J; Qumsiyeh MB; Nichols W; Van Dyke T. 1998. No requirement for V(D)J recombination in p53-deficient thymic lymphoma.. In: . . MGI: J:47667
Liao YJ; Fang CC; Yen CH; Hsu SM; Wang CK; Huang SF; Liang YC; Lin YY; Chu YT; Arthur Chen YM. 2015. Niemann-Pick type C2 protein regulates liver cancer progression via modulating ERK1/2 pathway: Clinicopathological correlations and therapeutical implications.. In: . . MGI: J:222874
Libby SJ; Brehm MA; Greiner DL; Shultz LD; McClelland M; Smith KD; Cookson BT; Karlinsey JE; Kinkel TL; Porwollik S; Canals R; Cummings LA; Fang FC. 2010. Humanized nonobese diabetic-scid IL2rgammanull mice are susceptible to lethal Salmonella Typhi infection.. In: . . MGI: J:163745
Liebe B; Petukhova G; Barchi M; Bellani M; Braselmann H; Nakano T; Pandita TK; Jasin M; Fornace A; Meistrich ML; Baarends WM; Schimenti J; de Lange T; Keeney S; Camerini-Otero RD; Scherthan H. 2006. Mutations that affect meiosis in male mice influence the dynamics of the mid-preleptotene and bouquet stages.. In: . . MGI: J:147391
Liebler JM; Lutzko C; Banfalvi A; Senadheera D; Aghamohammadi N; Crandall ED; Borok Z. 2008. Retention of human bone marrow-derived cells in murine lungs following bleomycin-induced lung injury.. In: . . MGI: J:138638
Lieke T; Steeg C; Graefe SE; Fleischer B; Jacobs T. 2006. Interaction of natural killer cells with Trypanosoma cruzi-infected fibroblasts.. In: . . MGI: J:112856
Lin P; Li W; Yao Z; Sun Y; Wang L; Li S; Chen L. 2015. Oral administration of PDX1 confers protection against insulitis in the non-obese diabetic (NOD) mice.. In: . . MGI: J:232937
Liu D; Zhang T; Marshall AJ; Okkenhaug K; Vanhaesebroeck B; Uzonna JE. 2009. The p110delta isoform of phosphatidylinositol 3-kinase controls susceptibility to Leishmania major by regulating expansion and tissue homing of regulatory T cells.. In: . . MGI: J:151583
Liu R; Liu C; Chen D; Yang WH; Liu X; Liu CG; Dugas CM; Tang F; Zheng P; Liu Y; Wang L. 2015. FOXP3 Controls an miR-146/NF-kappaB Negative Feedback Loop That Inhibits Apoptosis in Breast Cancer Cells.. In: . . MGI: J:220159
Liu Y; Carlsson R; Comabella M; Wang J; Kosicki M; Carrion B; Hasan M; Wu X; Montalban X; Dziegiel MH; Sellebjerg F; Sorensen PS; Helin K; Issazadeh-Navikas S. 2014. FoxA1 directs the lineage and immunosuppressive properties of a novel regulatory T cell population in EAE and MS.. In: . . MGI: J:208760
Llamas B; Belanger S; Picard S; Deschepper CF. 2007. Cardiac mass and cardiomyocyte size are governed by different genetic loci on either autosomes or chromosome Y in recombinant inbred mice.. In: . . MGI: J:127219
Lode HN; Xiang R; Pertl U; Forster E; Schoenberger SP; Gillies SD; Reisfeld RA. 2000. Melanoma immunotherapy by targeted IL-2 depends on CD4(+) T-cell help mediated by CD40/CD40L interaction.. In: . . MGI: J:62762
Londono D; Bai Y; Zuckert WR; Gelderblom H; Cadavid D. 2005. Cardiac apoptosis in severe relapsing fever borreliosis.. In: . . MGI: J:104291
Long AH; Haso WM; Shern JF; Wanhainen KM; Murgai M; Ingaramo M; Smith JP; Walker AJ; Kohler ME; Venkateshwara VR; Kaplan RN; Patterson GH; Fry TJ; Orentas RJ; Mackall CL. 2015. 4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors.. In: . . MGI: J:228468
Lou YR; Peng QY; Li T; Medvecky CM; Lin Y; Shih WJ; Conney AH; Shapses S; Wagner GC; Lu YP. 2011. Effects of high-fat diets rich in either omega-3 or omega-6 fatty acids on UVB-induced skin carcinogenesis in SKH-1 mice.. In: . . MGI: J:173643
Lu L; Ghose AK; Quail MR; Albom MS; Durkin JT; Holskin BP; Angeles TS; Meyer SL; Ruggeri BA; Cheng M. 2009. ALK mutants in the kinase domain exhibit altered kinase activity and differential sensitivity to small molecule ALK inhibitors.. In: . . MGI: J:149248
Lu M; Kardel MD; O'Connor MD; Eaves CJ. 2009. Enhanced generation of hematopoietic cells from human hepatocarcinoma cell-stimulated human embryonic and induced pluripotent stem cells.. In: . . MGI: J:151435
Lucas S; Taront S; Magnan C; Fauconnier L; Delacre M; Macia L; Delanoye A; Verwaerde C; Spriet C; Saule P; Goormachtigh G; Heliot L; Ktorza A; Movassat J; Polakowska R; Auriault C; Poulain-Godefroy O; Di Santo J; Froguel P; Wolowczuk I. 2012. Interleukin-7 regulates adipose tissue mass and insulin sensitivity in high-fat diet-fed mice through lymphocyte-dependent and independent mechanisms.. In: . . MGI: J:187900
Lukacs RU; Memarzadeh S; Wu H; Witte ON. 2010. Bmi-1 is a crucial regulator of prostate stem cell self-renewal and malignant transformation.. In: . . MGI: J:168487
Luo X; Tarbell KV; Yang H; Pothoven K; Bailey SL; Ding R; Steinman RM; Suthanthiran M. 2007. Dendritic cells with TGF-beta1 differentiate naive CD4+CD25- T cells into islet-protective Foxp3+ regulatory T cells.. In: . . MGI: J:125908
MacKenzie DA; Sollinger HW; Hullett DA. 1996. Acute graft rejection of human fetal pancreas allografts using donor-specific human peripheral blood lymphocytes in the SCID mouse.. In: . . MGI: J:33268
Madlambayan GJ; Meacham AM; Hosaka K; Mir S; Jorgensen M; Scott EW; Siemann DW; Cogle CR. 2010. Leukemia regression by vascular disruption and antiangiogenic therapy.. In: . . MGI: J:164541
Maeda K; Nagasawa H; Furukawa A; Hisaeda H; Himeno K. 1994. Split tolerance between spleen and lymph node cells in severe combined immunodeficiency mice grafted with AKR fetal liver cells.. In: . . MGI: J:22574
Mahler M; Bristol IJ; Leiter EH; Workman AE; Birkenmeier EH; Elson CO; Sundberg JP. 1998. Differential susceptibility of inbred mouse strains to dextran sulfate sodium-induced colitis.. In: . . MGI: J:46553
Majeti R; Park CY; Weissman IL. 2007. Identification of a hierarchy of multipotent hematopoietic progenitors in human cord blood.. In: . . MGI: J:142413
Majumder M; Xin X; Liu L; Tutunea-Fatan E; Rodriguez-Torres M; Vincent K; Postovit LM; Hess D; Lala PK. 2016. COX-2 Induces Breast Cancer Stem Cells via EP4/PI3K/AKT/NOTCH/WNT Axis.. In: . . MGI: J:238376
Mamalaki C; Elliott J; Norton T; Yannoutsos N; Townsend AR; Chandler P; Simpson E; Kioussis D. 1993. Positive and negative selection in transgenic mice expressing a T-cell receptor specific for influenza nucleoprotein and endogenous superantigen.. In: . . MGI: J:113713
Mangada J; Pearson T; Brehm MA; Wicker LS; Peterson LB; Shultz LD; Serreze DV; Rossini AA; Greiner DL. 2009. Idd loci synergize to prolong islet allograft survival induced by costimulation blockade in NOD mice.. In: . . MGI: J:146982
Manis JP; Dudley D; Kaylor L; Alt FW. 2002. IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cells.. In: . . MGI: J:113521
Manuel JA; Gawronska-Kozak B. 2006. Matrix metalloproteinase 9 (MMP-9) is upregulated during scarless wound healing in athymic nude mice.. In: . . MGI: J:116052
Marigo I; Zilio S; Desantis G; Mlecnik B; Agnellini AH; Ugel S; Sasso MS; Qualls JE; Kratochvill F; Zanovello P; Molon B; Ries CH; Runza V; Hoves S; Bilocq AM; Bindea G; Mazza EM; Bicciato S; Galon J; Murray PJ; Bronte V. 2016. T Cell Cancer Therapy Requires CD40-CD40L Activation of Tumor Necrosis Factor and Inducible Nitric-Oxide-Synthase-Producing Dendritic Cells.. In: . . MGI: J:234978
Marino E; Walters SN; Villanueva JE; Richards JL; Mackay CR; Grey ST. 2014. BAFF regulates activation of self-reactive T cells through B-cell dependent mechanisms and mediates protection in NOD mice.. In: . . MGI: J:209374
Marron MP; Graser RT; Chapman HD; Serreze DV. 2002. Functional evidence for the mediation of diabetogenic T cell responses by HLA-A2.1 MHC class I molecules through transgenic expression in NOD mice.. In: . . MGI: J:109851
Marsden MD; Kovochich M; Suree N; Shimizu S; Mehta R; Cortado R; Bristol G; An DS; Zack JA. 2012. HIV Latency in the Humanized BLT Mouse.. In: . . MGI: J:179389
Masaki T; Qu J; Cholewa-Waclaw J; Burr K; Raaum R; Rambukkana A. 2013. Reprogramming adult Schwann cells to stem cell-like cells by leprosy bacilli promotes dissemination of infection.. In: . . MGI: J:214507
Matsuoka K; Saito M; Shibata K; Sekine M; Shitara H; Taya C; Zhang X; Takahashi TA; Kohno K; Kikkawa Y; Yonekawa H. 2013. Generation of mouse models for type 1 diabetes by selective depletion of pancreatic beta cells using toxin receptor-mediated cell knockout.. In: . . MGI: J:204420
Maykel J; Liu JH; Li H; Shultz LD; Greiner DL; Houghton J. 2014. NOD-scidIl2rg (tm1Wjl) and NOD-Rag1 (null) Il2rg (tm1Wjl) : a model for stromal cell-tumor cell interaction for human colon cancer.. In: . . MGI: J:227975
McCool TL; Weiser JN. 2004. Limited role of antibody in clearance of Streptococcus pneumoniae in a murine model of colonization.. In: . . MGI: J:93131
McDermott SP; Eppert K; Lechman ER; Doedens M; Dick JE. 2010. Comparison of human cord blood engraftment between immunocompromised mouse strains.. In: . . MGI: J:162809
McIntosh BE; Brown ME; Duffin BM; Maufort JP; Vereide DT; Slukvin II; Thomson JA. 2015. Nonirradiated NOD,B6.SCID Il2rgamma(-/-)Kit(W41/W41) (NBSGW) Mice Support Multilineage Engraftment of Human Hematopoietic Cells.. In: . . MGI: J:218738
Mehta S; Huillard E; Kesari S; Maire CL; Golebiowski D; Harrington EP; Alberta JA; Kane MF; Theisen M; Ligon KL; Rowitch DH; Stiles CD. 2011. The Central Nervous System-Restricted Transcription Factor Olig2 Opposes p53 Responses to Genotoxic Damage in Neural Progenitors and Malignant Glioma.. In: . . MGI: J:169930
Meissner N; Swain S; McInnerney K; Han S; Harmsen AG. 2010. Type-I IFN signaling suppresses an excessive IFN-gamma response and thus prevents lung damage and chronic inflammation during pneumocystis (PC) clearance in CD4 T cell-competent mice.. In: . . MGI: J:161163
Meissner NN; Swain S; Tighe M; Harmsen A; Harmsen A. 2005. Role of type I IFNs in pulmonary complications of Pneumocystis murina infection.. In: . . MGI: J:98407
Miller RD; Hogg J; Ozaki JH; Gell D; Jackson SP; Riblet R. 1995. Gene for the catalytic subunit of mouse DNA-dependent protein kinase maps to the scid locus.. In: . . MGI: J:29679
Mishra A; Brown AL; Yao X; Yang S; Park SJ; Liu C; Dagur PK; McCoy JP; Keeran KJ; Nugent GZ; Jeffries KR; Qu X; Yu ZX; Levine SJ; Chung JH. 2015. Dendritic cells induce Th2-mediated airway inflammatory responses to house dust mite via DNA-dependent protein kinase.. In: . . MGI: J:221358
Mishra A; Das B; Nath M; Iyer S; Kesarwani A; Bhattacharjee J; Arindkar S; Sahay P; Jain K; Sahu P; Sinha P; Velpandian T; Nagarajan P; Upadhyay P. 2017. A novel immunodeficient NOD.SCID-rd1 mouse model of retinitis pigmentosa to investigate potential therapeutics and pathogenesis of retinal degeneration.. In: . . MGI: J:242067
Mishra R; Chen AT; Welsh RM; Szomolanyi-Tsuda E. 2010. NK cells and gammadelta T cells mediate resistance to polyomavirus-induced tumors.. In: . . MGI: J:162921
Mizrahi K; Stein J; Pearl-Yafe M; Kaplan O; Yaniv I; Askenasy N. 2010. Regulatory functions of TRAIL in hematopoietic progenitors: human umbilical cord blood and murine bone marrow transplantation.. In: . . MGI: J:162490
Montecino-Rodriguez E; Leathers H; Dorshkind K. 2006. Identification of a B-1 B cell-specified progenitor.. In: . . MGI: J:112481
Monteiro JP; Benjamin A; Costa ES; Barcinski MA; Bonomo A. 2005. Normal hematopoiesis is maintained by activated bone marrow CD4+ T cells.. In: . . MGI: J:96600
Morris SC; Heidorn SM; Herbert DR; Perkins C; Hildeman DA; Khodoun MV; Finkelman FD. 2009. Endogenously produced IL-4 nonredundantly stimulates CD8+ T cell proliferation.. In: . . MGI: J:144327
Morrison C; Smith GC; Stingl L; Jackson SP; Wagner EF; Wang ZQ. 1997. Genetic interaction between PARP and DNA-PK in V(D)J recombination and tumorigenesis.. In: . . MGI: J:75374
Mosier DE; Stell KL; Gulizia RJ; Torbett BE; Gilmore GL. 1993. Homozygous scid/scid;beige/beige mice have low levels of spontaneous or neonatal T cell-induced B cell generation.. In: . . MGI: J:3479
Mota J; Rico-Hesse R. 2009. Humanized mice show clinical signs of dengue fever according to infecting virus genotype.. In: . . MGI: J:153922
Mustafi R; Dougherty U; Shah H; Dehghan H; Gliksberg A; Wu J; Zhu H; Joseph L; Hart J; Dive C; Fichera A; Threadgill D; Bissonnette M. 2012. Both stromal cell and colonocyte epidermal growth factor receptors control HCT116 colon cancer cell growth in tumor xenografts.. In: . . MGI: J:192954
Mutwiri G K; Kosecka U; Benjamin M; Rosendal S; Perdue M; Butler D G. 2001. Mycobacterium avium subspecies paratuberculosis triggers intestinal pathophysiologic changes in beige/scid mice.. In: . . MGI: J:73720
Nacht M; Strasser A; Chan YR; Harris AW; Schlissel M; Bronson RT; Jacks T. 1996. Mutations in the p53 and SCID genes cooperate in tumorigenesis.. In: . . MGI: J:35055
Nakayama M; Beilke JN; Jasinski JM; Kobayashi M; Miao D; Li M; Coulombe MG; Liu E; Elliott JF; Gill RG; Eisenbarth GS. 2007. Priming and effector dependence on insulin B:9-23 peptide in NOD islet autoimmunity.. In: . . MGI: J:124210
Naramura M; Nandwani N; Gu H; Band V; Band H. 2010. Rapidly fatal myeloproliferative disorders in mice with deletion of Casitas B-cell lymphoma (Cbl) and Cbl-b in hematopoietic stem cells.. In: . . MGI: J:164365
Nemoto Y; Kanai T; Takahara M; Oshima S; Okamoto R; Tsuchiya K; Matsumoto S; Watanabe M. 2013. Th1/Th17-mediated interstitial pneumonia in chronic colitis mice independent of intestinal microbiota.. In: . . MGI: J:204854
Niimi N; Sugo N; Aratani Y; Koyama H. 2005. Genetic interaction between DNA polymerase beta and DNA-PKcs in embryogenesis and neurogenesis.. In: . . MGI: J:106364
Nishiyama Y; Hamada H; Nonaka S; Yamamoto H; Nanno M; Katayama Y; Takahashi H; Ishikawa H. 2002. Homeostatic regulation of intestinal villous epithelia by B lymphocytes.. In: . . MGI: J:126867
Nonaka S; Naito T; Chen H; Yamamoto M; Moro K; Kiyono H; Hamada H; Ishikawa H. 2005. Intestinal gammadelta T cells develop in mice lacking thymus, all lymph nodes, Peyer's patches, and isolated lymphoid follicles.. In: . . MGI: J:96579
Nonoyama S; Smith FO; Bernstein ID; Ochs HD. 1993. Strain-dependent leakiness of mice with severe combined immune deficiency.. In: . . MGI: J:4610
Noorchashm H; Reed AJ; Rostami SY; Mozaffari R; Zekavat G; Koeberlein B; Caton AJ; Naji A. 2006. B cell-mediated antigen presentation is required for the pathogenesis of acute cardiac allograft rejection.. In: . . MGI: J:140848
Notley CA; Inglis JJ; Alzabin S; McCann FE; McNamee KE; Williams RO. 2008. Blockade of tumor necrosis factor in collagen-induced arthritis reveals a novel immunoregulatory pathway for Th1 and Th17 cells.. In: . . MGI: J:140651
Nucera S; Giustacchini A; Boccalatte F; Calabria A; Fanciullo C; Plati T; Ranghetti A; Garcia-Manteiga J; Cittaro D; Benedicenti F; Lechman ER; Dick JE; Ponzoni M; Ciceri F; Montini E; Gentner B; Naldini L. 2016. miRNA-126 Orchestrates an Oncogenic Program in B Cell Precursor Acute Lymphoblastic Leukemia.. In: . . MGI: J:232327
O'Boyle G; Fox CR; Walden HR; Willet JD; Mavin ER; Hine DW; Palmer JM; Barker CE; Lamb CA; Ali S; Kirby JA. 2012. Chemokine receptor CXCR3 agonist prevents human T-cell migration in a humanized model of arthritic inflammation.. In: . . MGI: J:182231
O'Hara JR; Skinn AC; MacNaughton WK; Sherman PM; Sharkey KA. 2006. Consequences of Citrobacter rodentium infection on enteroendocrine cells and the enteric nervous system in the mouse colon.. In: . . MGI: J:135756
O'Malley JT; Eri RD; Stritesky GL; Mathur AN; Chang HC; Hogenesch H; Srinivasan M; Kaplan MH. 2008. STAT4 isoforms differentially regulate Th1 cytokine production and the severity of inflammatory bowel disease.. In: . . MGI: J:142733
O'Reilly LA; Harris AW; Strasser A. 1997. bcl-2 transgene expression promotes survival and reduces proliferation of CD3-CD4-CD8- T cell progenitors.. In: . . MGI: J:93122
O'Reilly LA; Harris AW; Tarlinton DM; Corcoran LM; Strasser A. 1997. Expression of a bcl-2 transgene reduces proliferation and slows turnover of developing B lymphocytes in vivo.. In: . . MGI: J:93123
Ochiai M; Ubagai T; Kawamori T; Imai H; Sugimura T; Nakagama H. 2001. High susceptibility of Scid mice to colon carcinogenesis induced by azoxymethane indicates a possible caretaker role for DNA-dependent protein kinase.. In: . . MGI: J:84343
Ohsugi T; Kiuchi Y; Shimoda K; Oguri S; Maejima K. 1996. Translocation of bacteria from the gastrointestinal tract in immunodeficient mice.. In: . . MGI: J:31261
Oida T; Suzuki K; Nanno M; Kanamori Y; Saito H; Kubota E; Kato S; Itoh M; Kaminogawa S; Ishikawa H. 2000. Role of gut cryptopatches in early extrathymic maturation of intestinal intraepithelial T cells.. In: . . MGI: J:112139
Okada K; Shoda J; Taguchi K; Maher JM; Ishizaki K; Inoue Y; Ohtsuki M; Goto N; Takeda K; Utsunomiya H; Oda K; Warabi E; Ishii T; Osaka K; Hyodo I; Yamamoto M. 2008. Ursodeoxycholic acid stimulates Nrf2-mediated hepatocellular transport, detoxification, and antioxidative stress systems in mice.. In: . . MGI: J:142149
Okazaki T; Okazaki IM; Wang J; Sugiura D; Nakaki F; Yoshida T; Kato Y; Fagarasan S; Muramatsu M; Eto T; Hioki K; Honjo T. 2011. PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice.. In: . . MGI: J:176845
Okazuka K; Wakabayashi Y; Kashihara M; Inoue J; Sato T; Yokoyama M; Aizawa S; Aizawa Y; Mishima Y; Kominami R. 2005. p53 prevents maturation of T cell development to the immature CD4(-)CD8(+) stage in Bcl11b(-/-) mice.. In: . . MGI: J:96179
Omori K; Mitsuhashi M; Ishiyama K; Nair I; Rawson J; Todorov I; Kandeel F; Mullen Y. 2011. mRNA of the pro-apoptotic gene BBC3 serves as a molecular marker for TNF-alpha-induced islet damage in humans.. In: . . MGI: J:175299
Opata MM; Ye Z; Hollifield M; Garvy BA. 2013. B Cell Production of Tumor Necrosis Factor in Response to Pneumocystis murina Infection in Mice.. In: . . MGI: J:201876
Origanti S; Cai SR; Munir AZ; White LS; Piwnica-Worms H. 2013. Synthetic lethality of Chk1 inhibition combined with p53 and/or p21 loss during a DNA damage response in normal and tumor cells.. In: . . MGI: J:193369
Oruganti SR; Torres DJ; Krebsbach S; Asperti-Boursin F; Winters J; Matlawska-Wasowska K; Winter SS; Halsey C; Cannon JL. 2017. CARMA1 is a novel regulator of T-ALL disease and leukemic cell migration to the CNS.. In: . . MGI: J:237842
Osmond DG; Kim N; Manoukian R; Phillips RA; Rico-Vargas SA; Jacobsen K. 1992. Dynamics and localization of early B-lymphocyte precursor cells (pro-B cells) in the bone marrow of scid mice.. In: . . MGI: J:737
Owyang AM; Zaph C; Wilson EH; Guild KJ; McClanahan T; Miller HR; Cua DJ; Goldschmidt M; Hunter CA; Kastelein RA; Artis D. 2006. Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract.. In: . . MGI: J:123808
Ozaki H; Mori K; Nakagawa Y; Hoshikawa S; Ito S; Inoue Y; Takai T; Yoshida K. 2009. Autoimmune thyroiditis in Fcgamma receptor-deficient nonobese diabetic mice.. In: . . MGI: J:151452
Paciorkowski N; Porte P; Shultz LD; Rajan TV. 2000. B1 B lymphocytes play a critical role in host protection against lymphatic filarial parasites.. In: . . MGI: J:112016
Paliwal P; Conboy IM. 2011. Inhibitors of tyrosine phosphatases and apoptosis reprogram lineage-marked differentiated muscle to myogenic progenitor cells.. In: . . MGI: J:190199
Pancewicz J; Taylor JM; Datta A; Baydoun HH; Waldmann TA; Hermine O; Nicot C. 2010. Notch signaling contributes to proliferation and tumor formation of human T-cell leukemia virus type 1-associated adult T-cell leukemia.. In: . . MGI: J:164350
Papagiannakopoulos T; Friedmann-Morvinski D; Neveu P; Dugas JC; Gill RM; Huillard E; Liu C; Zong H; Rowitch DH; Barres BA; Verma IM; Kosik KS. 2012. Pro-neural miR-128 is a glioma tumor suppressor that targets mitogenic kinases.. In: . . MGI: J:186143
Papeta N; Zheng Z; Schon EA; Brosel S; Altintas MM; Nasr SH; Reiser J; D'Agati VD; Gharavi AG. 2010. Prkdc participates in mitochondrial genome maintenance and prevents Adriamycin-induced nephropathy in mice.. In: . . MGI: J:166909
Park CW; Ryu HW; Ryu KY. 2012. Locus coeruleus neurons are resistant to dysfunction and degeneration by maintaining free ubiquitin levels although total ubiquitin levels decrease upon disruption of polyubiquitin gene Ubb.. In: . . MGI: J:181255
Park JS; Kim IK; Han S; Park I; Kim C; Bae J; Oh SJ; Lee S; Kim JH; Woo DC; He Y; Augustin HG; Kim I; Lee D; Koh GY. 2016. Normalization of Tumor Vessels by Tie2 Activation and Ang2 Inhibition Enhances Drug Delivery and Produces a Favorable Tumor Microenvironment.. In: . . MGI: J:238058
Pathania R; Ramachandran S; Elangovan S; Padia R; Yang P; Cinghu S; Veeranan-Karmegam R; Arjunan P; Gnana-Prakasam JP; Sadanand F; Pei L; Chang CS; Choi JH; Shi H; Manicassamy S; Prasad PD; Sharma S; Ganapathy V; Jothi R; Thangaraju M. 2015. DNMT1 is essential for mammary and cancer stem cell maintenance and tumorigenesis.. In: . . MGI: J:222799
Pathania R; Ramachandran S; Mariappan G; Thakur P; Shi H; Choi JH; Manicassamy S; Kolhe R; Prasad PD; Sharma S; Lokeshwar BL; Ganapathy V; Thangaraju M. 2016. Combined Inhibition of DNMT and HDAC Blocks the Tumorigenicity of Cancer Stem-like Cells and Attenuates Mammary Tumor Growth.. In: . . MGI: J:232034
Pauza ME; Dobbs CM; He J; Patterson T; Wagner S; Anobile BS; Bradley BJ; Lo D; Haskins K. 2004. T-cell receptor transgenic response to an endogenous polymorphic autoantigen determines susceptibility to diabetes.. In: . . MGI: J:89082
Pearson T; Greiner DL; Shultz LD. 2008. Creation of 'humanized' mice to study human immunity.. In: . . MGI: J:151386
Pearson T; Shultz LD; Lief J; Burzenski L; Gott B; Chase T; Foreman O; Rossini AA; Bottino R; Trucco M; Greiner DL. 2008. A new immunodeficient hyperglycaemic mouse model based on the Ins2 ( Akita ) mutation for analyses of human islet and beta stem and progenitor cell function.. In: . . MGI: J:138005
Pearson T; Shultz LD; Miller D; King M; Laning J; Fodor W; Cuthbert A; Burzenski L; Gott B; Lyons B; Foreman O; Rossini AA; Greiner DL. 2008. Non-obese diabetic-recombination activating gene-1 (NOD-Rag1 null) interleukin (IL)-2 receptor common gamma chain (IL2r gamma null) null mice: a radioresistant model for human lymphohaematopoietic engraftment.. In: . . MGI: J:140388
Pedraza-Alva G; Koulnis M; Charland C; Thornton T; Clements JL; Schlissel MS; Rincon M. 2006. Activation of p38 MAP kinase by DNA double-strand breaks in V(D)J recombination induces a G2/M cell cycle checkpoint.. In: . . MGI: J:105987
Pei Y; Moore CE; Wang J; Tewari AK; Eroshkin A; Cho YJ; Witt H; Korshunov A; Read TA; Sun JL; Schmitt EM; Miller CR; Buckley AF; McLendon RE; Westbrook TF; Northcott PA; Taylor MD; Pfister SM; Febbo PG; Wechsler-Reya RJ. 2012. An Animal Model of MYC-Driven Medulloblastoma.. In: . . MGI: J:181463
Percy DH; Auger DC; Croy BA. 1994. Signs and lesions of experimental Sendai virus infection in two genetically distinct strains of SCID/beige mice.. In: . . MGI: J:17913
Percy DH; Barta JR. 1993. Spontaneous and experimental infections in scid and scid/beige mice.. In: . . MGI: J:4752
Perone MJ; Bertera S; Tawadrous ZS; Shufesky WJ; Piganelli JD; Baum LG; Trucco M; Morelli AE. 2006. Dendritic cells expressing transgenic galectin-1 delay onset of autoimmune diabetes in mice.. In: . . MGI: J:139444
Petitto JM; Huang Z; Lo J; Streit WJ. 2003. IL-2 gene knockout affects T lymphocyte trafficking and the microglial response to regenerating facial motor neurons.. In: . . MGI: J:105891
Phillips JM; Parish NM; Drage M; Cooke A. 2001. Cutting edge: interactions through the IL-10 receptor regulate autoimmune diabetes.. In: . . MGI: J:119045
Pierce EM; Carpenter K; Jakubzick C; Kunkel SL; Flaherty KR; Martinez FJ; Hogaboam CM. 2007. Therapeutic targeting of CC ligand 21 or CC chemokine receptor 7 abrogates pulmonary fibrosis induced by the adoptive transfer of human pulmonary fibroblasts to immunodeficient mice.. In: . . MGI: J:120124
Pierce MA; Chapman HD; Post CM; Svetlanov A; Efrat S; Horwitz M; Serreze DV. 2003. Adenovirus early region 3 antiapoptotic 10.4K, 14.5K, and 14.7K genes decrease the incidence of autoimmune diabetes in NOD mice.. In: . . MGI: J:83195
Plenter RJ; Grazia TJ; Nelson DP; Zamora MR; Gill RG; Pietra BA. 2015. Ectopic expression of Fas Ligand on cardiomyocytes renders cardiac allografts resistant to CD4(+) T-cell mediated rejection.. In: . . MGI: J:223254
Porubsky S; Wang S; Kiss E; Dehmel S; Bonrouhi M; Dorn T; Luckow B; Brakebusch C; Grone HJ. 2011. Rhoh deficiency reduces peripheral T-cell function and attenuates allogenic transplant rejection.. In: . . MGI: J:174659
Powrie F; Leach MW; Mauze S; Menon S; Caddle LB; Coffman RL. 1994. Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells.. In: . . MGI: J:133778
Prochazka M; Gaskins HR; Shultz LD; Leiter EH. 1992. The nonobese diabetic scid mouse: model for spontaneous thymomagenesis associated with immunodeficiency.. In: . . MGI: J:513
Purwana I; Zheng J; Li X; Deurloo M; Son DO; Zhang Z; Liang C; Shen E; Tadkase A; Feng ZP; Li Y; Hasilo C; Paraskevas S; Bortell R; Greiner DL; Atkinson M; Prud'homme GJ; Wang Q. 2014. GABA promotes human beta-cell proliferation and modulates glucose homeostasis.. In: . . MGI: J:230144
Qing Y; Lin Y; Gerson SL. 2012. An intrinsic BM hematopoietic niche occupancy defect of HSC in scid mice facilitates exogenous HSC engraftment.. In: . . MGI: J:181738
Qualls JE; Kaplan AM; van Rooijen N; Cohen DA. 2006. Suppression of experimental colitis by intestinal mononuclear phagocytes.. In: . . MGI: J:113033
Quintana E; Shackleton M; Sabel MS; Fullen DR; Johnson TM; Morrison SJ. 2008. Efficient tumour formation by single human melanoma cells.. In: . . MGI: J:142408
Rappa G; Mercapide J; Lorico A. 2012. Spontaneous Formation of Tumorigenic Hybrids between Breast Cancer and Multipotent Stromal Cells Is a Source of Tumor Heterogeneity.. In: . . MGI: J:184798
Rauch DA; Hurchla MA; Harding JC; Deng H; Shea LK; Eagleton MC; Niewiesk S; Lairmore MD; Piwnica-Worms D; Rosol TJ; Weber JD; Ratner L; Weilbaecher KN. 2010. The ARF tumor suppressor regulates bone remodeling and osteosarcoma development in mice.. In: . . MGI: J:168312
Rauner G; Leviav A; Mavor E; Barash I. 2013. Development of Foreign Mammary Epithelial Morphology in the Stroma of Immunodeficient Mice.. In: . . MGI: J:204342
Read TA; Fogarty MP; Markant SL; McLendon RE; Wei Z; Ellison DW; Febbo PG; Wechsler-Reya RJ. 2009. Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma.. In: . . MGI: J:144811
Riggs J; Stowers R. 1996. Ability of spleen, peritoneal cavity, and lymph node B cells to reconstitute serum immunoglobulin in SCID mice.. In: . . MGI: J:32916
Riggs JE; Feeney AJ; Kirven M; Mosier DE. 1994. VH11 bias and normal V-D-J junctions in SCID B lymphocytes rescued by neonatal T cell transfer.. In: . . MGI: J:19789
Rival C; Samy E; Setiady Y; Tung K. 2013. Cutting edge: Ly49C/I(-) neonatal NK cells predispose newborns to autoimmune ovarian disease induced by maternal autoantibody.. In: . . MGI: J:205867
Rivera J; Zaragoza O; Casadevall A. 2005. Antibody-mediated protection against Cryptococcus neoformans pulmonary infection is dependent on B cells.. In: . . MGI: J:95620
Roberts JL; Abe R; Shores EW; Singer A. 1992. Expression of Mls determinants in mice exhibiting the severe combined immunodeficiency (scid) mutation or X-linked immunodeficiency (xid) defect.. In: . . MGI: J:2072
Rochford R; Ohrt C; Baresel PC; Campo B; Sampath A; Magill AJ; Tekwani BL; Walker LA. 2013. Humanized mouse model of glucose 6-phosphate dehydrogenase deficiency for in vivo assessment of hemolytic toxicity.. In: . . MGI: J:201977
Rodgers JT; King KY; Brett JO; Cromie MJ; Charville GW; Maguire KK; Brunson C; Mastey N; Liu L; Tsai CR; Goodell MA; Rando TA. 2014. mTORC1 controls the adaptive transition of quiescent stem cells from G0 to G(Alert).. In: . . MGI: J:213273
Rolink A; Melchers F; Andersson J. 1996. The SCID but not the RAG-2 gene product is required for S mu-S epsilon heavy chain class switching.. In: . . MGI: J:36026
Rosario CO; Ko MA; Haffani YZ; Gladdy RA; Paderova J; Pollett A; Squire JA; Dennis JW; Swallow CJ. 2010. Plk4 is required for cytokinesis and maintenance of chromosomal stability.. In: . . MGI: J:159310
Rosen C; Shezen E; Aronovich A; Klionsky YZ; Yaakov Y; Assayag M; Biton IE; Tal O; Shakhar G; Ben-Hur H; Shneider D; Vaknin Z; Sadan O; Evron S; Freud E; Shoseyov D; Wilschanski M; Berkman N; Fibbe WE; Hagin D; Hillel-Karniel C; Krentsis IM; Bachar-Lustig E; Reisner Y. 2015. Preconditioning allows engraftment of mouse and human embryonic lung cells, enabling lung repair in mice.. In: . . MGI: J:228759
Roths JB; Smith AL; Sidman CL. 1993. Lethal exacerbation of Pneumocystis carinii pneumonia in severe combined immunodeficiency mice after infection by pneumonia virus of mice.. In: . . MGI: J:109921
Rotolo JA; Mesicek J; Maj J; Truman JP; Haimovitz-Friedman A; Kolesnick R; Fuks Z. 2010. Regulation of ceramide synthase-mediated crypt epithelium apoptosis by DNA damage repair enzymes.. In: . . MGI: J:156862
Roy N; Takeuchi KK; Ruggeri JM; Bailey P; Chang D; Li J; Leonhardt L; Puri S; Hoffman MT; Gao S; Halbrook CJ; Song Y; Ljungman M; Malik S; Wright CV; Dawson DW; Biankin AV; Hebrok M; Crawford HC. 2016. PDX1 dynamically regulates pancreatic ductal adenocarcinoma initiation and maintenance.. In: . . MGI: J:238701
Ruan S; McKinley L; Zheng M; Rudner X; D'Souza A; Kolls JK; Shellito JE. 2008. Interleukin-12 and host defense against murine Pneumocystis pneumonia.. In: . . MGI: J:134470
Ruetsch NR; Bosma GC; Bosma MJ. 2000. Unexpected rearrangement and expression of the immunoglobulin lambda1 locus in scid mice.. In: . . MGI: J:62701
Rui J; Deng S; Lebastchi J; Clark PL; Usmani-Brown S; Herold KC. 2016. Methylation of insulin DNA in response to proinflammatory cytokines during the progression of autoimmune diabetes in NOD mice.. In: . . MGI: J:232925
Rynda-Apple A; Dobrinen E; McAlpine M; Read A; Harmsen A; Richert LE; Calverley M; Pallister K; Voyich J; Wiley JA; Johnson B; Young M; Douglas T; Harmsen AG. 2012. Virus-Like Particle-Induced Protection Against MRSA Pneumonia Is Dependent on IL-13 and Enhancement of Phagocyte Function.. In: . . MGI: J:185523
Saeed H; Abdallah BM; Ditzel N; Catala-Lehnen P; Qiu W; Amling M; Kassem M. 2011. Telomerase-deficient mice exhibit bone loss owing to defects in osteoblasts and increased osteoclastogenesis by inflammatory microenvironment.. In: . . MGI: J:233117
Sakai D; Nakamura Y; Nakai T; Mishima T; Kato S; Grad S; Alini M; Risbud MV; Chan D; Cheah KS; Yamamura K; Masuda K; Okano H; Ando K; Mochida J. 2012. Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc.. In: . . MGI: J:225067
Salem ML; Al-Khami AA; El-Naggar SA; Diaz-Montero CM; Chen Y; Cole DJ. 2010. Cyclophosphamide induces dynamic alterations in the host microenvironments resulting in a Flt3 ligand-dependent expansion of dendritic cells.. In: . . MGI: J:159482
Samy ET; Meyer CA; Caplazi P; Langrish CL; Lora JM; Bluethmann H; Peng SL. 2007. Cutting edge: Modulation of intestinal autoimmunity and IL-2 signaling by sphingosine kinase 2 independent of sphingosine 1-phosphate.. In: . . MGI: J:153014
Sandri S; Bobisse S; Moxley K; Lamolinara A; De Sanctis F; Boschi F; Sbarbati A; Fracasso G; Ferrarini G; Hendriks RW; Cavallini C; Scupoli MT; Sartoris S; Iezzi M; Nishimura MI; Bronte V; Ugel S. 2016. Feasibility of Telomerase-Specific Adoptive T-cell Therapy for B-cell Chronic Lymphocytic Leukemia and Solid Malignancies.. In: . . MGI: J:232028
Santidrian AF; Matsuno-Yagi A; Ritland M; Seo BB; LeBoeuf SE; Gay LJ; Yagi T; Felding-Habermann B. 2013. Mitochondrial complex I activity and NAD+/NADH balance regulate breast cancer progression.. In: . . MGI: J:196392
Saville SP; Lazzell AL; Chaturvedi AK; Monteagudo C; Lopez-Ribot JL. 2008. Use of a genetically engineered strain to evaluate the pathogenic potential of yeast cell and filamentous forms during Candida albicans systemic infection in immunodeficient mice.. In: . . MGI: J:130296
Savinov AY; Rozanov DV; Strongin AY. 2007. Specific inhibition of autoimmune T cell transmigration contributes to beta cell functionality and insulin synthesis in non-obese diabetic (NOD) mice.. In: . . MGI: J:126809
Savinov AY; Tcherepanov A; Green EA; Flavell RA; Chervonsky AV. 2003. Contribution of Fas to diabetes development.. In: . . MGI: J:81416
Savouret C; Brisson E; Essers J; Kanaar R; Pastink A; te Riele H; Junien C; Gourdon G. 2003. CTG repeat instability and size variation timing in DNA repair-deficient mice.. In: . . MGI: J:83373
Scheeren FA; Kuo AH; van Weele LJ; Cai S; Glykofridis I; Sikandar SS; Zabala M; Qian D; Lam JS; Johnston D; Volkmer JP; Sahoo D; van de Rijn M; Dirbas FM; Somlo G; Kalisky T; Rothenberg ME; Quake SR; Clarke MF. 2014. A cell-intrinsic role for TLR2-MYD88 in intestinal and breast epithelia and oncogenesis.. In: . . MGI: J:217693
Schito ML; Barta JR. 1997. Nonspecific immune responses and mechanisms of resistance to Eimeria papillata infections in mice.. In: . . MGI: J:41839
Schmidt RE; Dorsey DA; Beaudet LN; Frederick KE; Parvin CA; Plurad SB; Levisetti MG. 2003. Non-obese diabetic mice rapidly develop dramatic sympathetic neuritic dystrophy: a new experimental model of diabetic autonomic neuropathy.. In: . . MGI: J:86318
Schon MP; Schon M; Warren HB; Donohue JP; Parker CM. 2000. Cutaneous inflammatory disorder in integrin alphaE (CD103)-deficient mice.. In: . . MGI: J:110810
Schroder PM; Khattar M; Baum CE; Miyahara Y; Chen W; Vyas R; Muralidharan S; Mierzejewska B; Stepkowski SM. 2015. PD-1-dependent restoration of self-tolerance in the NOD mouse model of diabetes after transient anti-TCRbeta mAb therapy.. In: . . MGI: J:220839
Schuler W; Weiler IJ; Schuler A; Phillips RA; Rosenberg N; Mak TW; Kearney JF; Perry RP; Bosma MJ. 1986. Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency.. In: . . MGI: J:8420
Searles S; Gauss K; Wilkison M; Hoyt TR; Dobrinen E; Meissner N. 2013. Modulation of inflammasome-mediated pulmonary immune activation by type I IFNs protects bone marrow homeostasis during systemic responses to Pneumocystis lung infection.. In: . . MGI: J:205844
Seehus CR; Aliahmad P; de la Torre B; Iliev ID; Spurka L; Funari VA; Kaye J. 2015. The development of innate lymphoid cells requires TOX-dependent generation of a common innate lymphoid cell progenitor.. In: . . MGI: J:232838
Seif AE; Barrett DM; Milone M; Brown VI; Grupp SA; Reid GS. 2009. Long-term protection from syngeneic acute lymphoblastic leukemia by CpG ODN-mediated stimulation of innate and adaptive immune responses.. In: . . MGI: J:152910
Sekiguchi J; Ferguson DO; Chen HT; Yang EM; Earle J; Frank K; Whitlow S; Gu Y; Xu Y; Nussenzweig A; Alt FW. 2001. Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development.. In: . . MGI: J:68074
Sela U; Olds P; Park A; Schlesinger SJ; Steinman RM. 2011. Dendritic cells induce antigen-specific regulatory T cells that prevent graft versus host disease and persist in mice.. In: . . MGI: J:178615
Serpe CJ; Kohm AP; Huppenbauer CB; Sanders VM; Jones KJ. 1999. Exacerbation of facial motoneuron loss after facial nerve transection in severe combined immunodeficient (scid) mice.. In: . . MGI: J:120563
Serre L; Fazilleau N; Guerder S. 2015. Central tolerance spares the private high-avidity CD4(+) T-cell repertoire specific for an islet antigen in NOD mice.. In: . . MGI: J:229782
Serreze DV; Chapman HD; Varnum DS; Gerling I; Leiter EH; Shultz LD. 1997. Initiation of autoimmune diabetes in NOD/Lt mice is MHC class I-dependent.. In: . . MGI: J:39473
Serreze DV; Johnson EA; Chapman HD; Graser RT; Marron MP; DiLorenzo TP; Silveira P; Yoshimura Y; Nathenson SG; Joyce S. 2001. Autoreactive diabetogenic T-cells in NOD mice can efficiently expand from a greatly reduced precursor pool.. In: . . MGI: J:71050
Serreze DV; Leiter EH; Hanson MS; Christianson SW; Shultz LD; Hesselton RM; Greiner DL. 1995. Emv30null NOD-scid mice. An improved host for adoptive transfer of autoimmune diabetes and growth of human lymphohematopoietic cells.. In: . . MGI: J:29951
Severe S; Gauvrit A; Vu AT; Bach JM. 2007. CD8(+) T lymphocytes specific for glutamic acid decarboxylase 90-98 epitope mediate diabetes in NOD(SCID) mouse.. In: . . MGI: J:119811
Sewald X; Ladinsky MS; Uchil PD; Beloor J; Pi R; Herrmann C; Motamedi N; Murooka TT; Brehm MA; Greiner DL; Shultz LD; Mempel TR; Bjorkman PJ; Kumar P; Mothes W. 2015. Retroviruses use CD169-mediated trans-infection of permissive lymphocytes to establish infection.. In: . . MGI: J:226540
Shang L; Hua H; Foo K; Martinez H; Watanabe K; Zimmer M; Kahler DJ; Freeby M; Chung W; LeDuc C; Goland R; Leibel RL; Egli D. 2014. beta-cell dysfunction due to increased ER stress in a stem cell model of Wolfram syndrome.. In: . . MGI: J:208989
Shellito JE; Kolls JK; Olariu R; Beck JM. 1996. Nitric oxide and host defense against Pneumocystis carinii infection in a mouse model.. In: . . MGI: J:31163
Shen Y; Park CS; Suppipat K; Mistretta TA; Puppi M; Horton TM; Rabin K; Gray NS; Meijerink JPP; Lacorazza HD. 2017. Inactivation of KLF4 promotes T-cell acute lymphoblastic leukemia and activates the MAP2K7 pathway.. In: . . MGI: J:241802
Shibata S; Asano T; Ogura A; Hashimoto N; Hayakawa J; Uetsuka K ; Nakayama H ; Doi K. 1997. SCID-bg mice as xenograft recipients.. In: . . MGI: J:40569
Shoji S; Watanabe H; Katoh O; Masaoka Y; Matsuura S; Tauchi H; Endo S; Komatsu K. 1998. Developmental malformations and intrauterine deaths in gamma-ray-irradiated scid mouse embryos.. In: . . MGI: J:51083
Shores EW; Nakayama T; Wiest DL; Takahama Y; Sharrow S; Singer A. 1993. Structurally distinct T cell receptor complexes on developmentally distinct T cell populations in severe combined immunodeficiency mice expressing a TCR beta transgene.. In: . . MGI: J:111476
Shukla A; Rai K; Shukla V; Chaturvedi NK; Bociek RG; Pirruccello SJ; Band H; Lu R; Joshi SS. 2016. Sprouty 2: a novel attenuator of B-cell receptor and MAPK-Erk signaling in CLL.. In: . . MGI: J:232635
Shultz LD; Banuelos S; Lyons B; Samuels R; Burzenski L; Gott B; Lang P; Leif J; Appel M; Rossini A; Greiner DL. 2003. NOD/LtSz-Rag1nullPfpnull mice: a new model system with increased levels of human peripheral leukocyte and hematopoietic stem-cell engraftment.. In: . . MGI: J:109843
Shultz LD; Ishikawa F; Greiner DL. 2007. Humanized mice in translational biomedical research.. In: . . MGI: J:142414
Shultz LD; Lyons BL; Burzenski LM; Gott B; Chen X; Chaleff S; Kotb M; Gillies SD; King M; Mangada J; Greiner DL; Handgretinger R. 2005. Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells.. In: . . MGI: J:109833
Shultz LD; Saito Y; Najima Y; Tanaka S; Ochi T; Tomizawa M; Doi T; Sone A; Suzuki N; Fujiwara H; Yasukawa M; Ishikawa F. 2010. Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2r gamma(null) humanized mice.. In: . . MGI: J:162315
Shultz LD; Schweitzer PA; Christianson SW; Gott B; Schweitzer IB; Tennent B; McKenna S; Mobraaten L; Rajan TV; Greiner DL; Leiter EH. 1995. Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice.. In: . . MGI: J:22026
Shurin MR; Potapovich AI; Tyurina YY; Tourkova IL; Shurin GV; Kagan VE. 2009. Recognition of live phosphatidylserine-labeled tumor cells by dendritic cells: a novel approach to immunotherapy of skin cancer.. In: . . MGI: J:147072
Simard C; Klein SJ; Mak T; Jolicoeur P. 1997. Studies of the susceptibility of nude, CD4 knockout, and SCID mutant mice to the disease induced by the murine AIDS defective virus.. In: . . MGI: J:38897
Simons BW; Hurley PJ; Huang Z; Ross AE; Miller R; Marchionni L; Berman DM; Schaeffer EM. 2012. Wnt signaling though beta-catenin is required for prostate lineage specification.. In: . . MGI: J:190538
Simpson-Abelson MR; Sonnenberg GF; Takita H; Yokota SJ; Conway TF Jr; Kelleher RJ Jr; Shultz LD; Barcos M; Bankert RB. 2008. Long-term engraftment and expansion of tumor-derived memory T cells following the implantation of non-disrupted pieces of human lung tumor into NOD-scid IL2Rgamma(null) mice.. In: . . MGI: J:142412
Smith AA; Li J; Liu B; Hunter D; Pyles M; Gillette M; Dhamdhere GR; Abo A; Oro A; Helms JA. 2016. Activating Hair Follicle Stem Cells via R-spondin2 to Stimulate Hair Growth.. In: . . MGI: J:235025
Smythies LE; Waites KB; Lindsey JR; Harris PR; Ghiara P; Smith PD. 2000. Helicobacter pylori-induced mucosal inflammation is Th1 mediated and exacerbated in IL-4, but not IFN-gamma, gene-deficient mice.. In: . . MGI: J:120556
Song X; Guo Y; Duo S; Che J; Wu C; Ochiya T; Ding M; Deng H. 2009. A mouse model of inducible liver injury caused by tet-on regulated urokinase for studies of hepatocyte transplantation.. In: . . MGI: J:154703
Spranger S; Jeremias I; Wilde S; Leisegang M; Starck L; Mosetter B; Uckert W; Heemskerk MH; Schendel DJ; Frankenberger B. 2012. TCR-transgenic lymphocytes specific for HMMR/Rhamm limit tumor outgrowth in vivo.. In: . . MGI: J:183769
Stalder AK; Carson MJ; Pagenstecher A; Asensio VC; Kincaid C; Benedict M; Powell HC; Masliah E; Campbell IL. 1998. Late-onset chronic inflammatory encephalopathy in immune-competent and severe combined immune-deficient (SCID) mice with astrocyte-targeted expression of tumor necrosis factor.. In: . . MGI: J:106595
Stokes KY; Calahan L; Hamric CM; Russell JM; Granger DN. 2009. CD40/CD40L contributes to hypercholesterolemia-induced microvascular inflammation.. In: . . MGI: J:146361
Stone JL; McMillan RE; Skaar DA; Bradshaw JM; Jirtle RL; Sikes ML. 2012. DNA Double-Strand Breaks Relieve USF-Mediated Repression of Dbeta2 Germline Transcription in Developing Thymocytes.. In: . . MGI: J:181246
Stracker TH; Couto SS; Cordon-Cardo C; Matos T; Petrini JH. 2008. Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage.. In: . . MGI: J:138550
Stracker TH; Williams BR; Deriano L; Theunissen JW; Adelman CA; Roth DB; Petrini JH. 2009. Artemis and nonhomologous end joining-independent influence of DNA-dependent protein kinase catalytic subunit on chromosome stability.. In: . . MGI: J:144749
Strasser A; Harris AW; Corcoran LM; Cory S. 1994. Bcl-2 expression promotes B- but not T-lymphoid development in scid mice.. In: . . MGI: J:17426
Stratford EW; Bostad M; Castro R; Skarpen E; Berg K; Hogset A; Myklebost O; Selbo PK. 2013. Photochemical internalization of CD133-targeting immunotoxins efficiently depletes sarcoma cells with stem-like properties and reduces tumorigenicity.. In: . . MGI: J:202381
Strowig T; Chijioke O; Carrega P; Arrey F; Meixlsperger S; Ramer PC; Ferlazzo G; Munz C. 2010. Human NK cells of mice with reconstituted human immune system components require preactivation to acquire functional competence.. In: . . MGI: J:167434
Su MA; Davini D; Cheng P; Giang K; Fan U; DeVoss JJ; Johannes KP; Taylor L; Shum AK; Valenzise M; Meloni A; Bour-Jordan H; Anderson MS. 2012. Defective autoimmune regulator-dependent central tolerance to myelin protein zero is linked to autoimmune peripheral neuropathy.. In: . . MGI: J:188686
Su X; Hu Q; Kristan JM; Costa C; Shen Y; Gero D; Matis LA; Wang Y. 2000. Significant role for Fas in the pathogenesis of autoimmune diabetes.. In: . . MGI: J:127009
Suffia I; Reckling SK; Salay G; Belkaid Y. 2005. A role for CD103 in the retention of CD4+CD25+ Treg and control of Leishmania major infection.. In: . . MGI: J:98414
Sugiarto S; Persson AI; Munoz EG; Waldhuber M; Lamagna C; Andor N; Hanecker P; Ayers-Ringler J; Phillips J; Siu J; Lim DA; Vandenberg S; Stallcup W; Berger MS; Bergers G; Weiss WA; Petritsch C. 2011. Asymmetry-defective oligodendrocyte progenitors are glioma precursors.. In: . . MGI: J:175969
Sugiura K; Taketani S; Yoshimura T; Nishino T; Nishino N; Fujisawa J; Hisha H; Inaba T; Ikehara S. 2007. Effect of hepatocyte growth factor on long term hematopoiesis of human progenitor cells in transgenic-severe combined immunodeficiency mice.. In: . . MGI: J:126823
Sun X; Robertson SA; Ingman WV. 2013. Regulation of epithelial cell turnover and macrophage phenotype by epithelial cell-derived transforming growth factor beta1 in the mammary gland.. In: . . MGI: J:197873
Sundberg JP (ed.). 1994. Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools. In: Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools. CRC Press, Boca Raton. MGI: J:30359
Sundberg JP; Adkison DL; Bedigian HG. 1991. Skeletal muscle rhabdomyosarcomas in inbred laboratory mice.. In: . . MGI: J:24311
Sundberg JP; Boggess D; Sundberg BA; Beamer WG; Shultz LD. 1993. Epidermal dendritic cell populations in the flaky skin mutant mouse.. In: . . MGI: J:14506
Swaims AY; Khani F; Zhang Y; Roberts AI; Devadas S; Shi Y; Rabson AB. 2010. Immune activation induces immortalization of HTLV-1 LTR-Tax transgenic CD4+ T cells.. In: . . MGI: J:165866
Swain SD; Siemsen DW; Pullen RR; Han S. 2014. CD4+ T cells and IFN-gamma are required for the development of Pneumocystis-associated pulmonary hypertension.. In: . . MGI: J:206386
Szomolanyi-Tsuda E; Dundon PL; Joris I; Shultz LD; Woda BA; Welsh RM. 1994. Acute, lethal, natural killer cell-resistant myeloproliferative disease induced by polyomavirus in severe combined immunodeficient mice.. In: . . MGI: J:16875
Ta VB; de Haan AB; de Bruijn MJ; Dingjan GM; Hendriks RW. 2011. Pre-B-cell leukemias in Btk/Slp65-deficient mice arise independently of ongoing V(D)J recombination activity.. In: . . MGI: J:167638
Tadokoro Y; Ema H; Okano M; Li E; Nakauchi H. 2007. De novo DNA methyltransferase is essential for self-renewal, but not for differentiation, in hematopoietic stem cells.. In: . . MGI: J:125606
Takagi S; Saito Y; Hijikata A; Tanaka S; Watanabe T; Hasegawa T; Mochizuki S; Kunisawa J; Kiyono H; Koseki H; Ohara O; Saito T; Taniguchi S; Shultz LD; Ishikawa F. 2012. Membrane-bound human SCF/KL promotes in vivo human hematopoietic engraftment and myeloid differentiation.. In: . . MGI: J:180274
Takahama Y; Sugaya K; Tsuda S; Hasegawa T; Hashimoto Y. 1995. Regulation of early T cell development by the engagement of TCR-beta complex expressed on fetal thymocytes from TCR-beta-transgenic scid mice.. In: . . MGI: J:25533
Takahashi Y; Inamine A; Hashimoto S; Haraguchi S; Yoshioka E; Kojima N; Abe R; Takemori T. 2005. Novel role of the Ras cascade in memory B cell response.. In: . . MGI: J:100532
Takata M; Nakagomi T; Kashiwamura S; Nakano-Doi A; Saino O; Nakagomi N; Okamura H; Mimura O; Taguchi A; Matsuyama T. 2012. Glucocorticoid-induced TNF receptor-triggered T cells are key modulators for survival/death of neural stem/progenitor cells induced by ischemic stroke.. In: . . MGI: J:203071
Takenaka K; Prasolava TK; Wang JC; Mortin-Toth SM; Khalouei S; Gan OI; Dick JE; Danska JS. 2007. Polymorphism in Sirpa modulates engraftment of human hematopoietic stem cells.. In: . . MGI: J:127760
Takeuchi D; Jones VC; Kobayashi M; Suzuki F. 2008. Cooperative role of macrophages and neutrophils in host Antiprotozoan resistance in mice acutely infected with Cryptosporidium parvum.. In: . . MGI: J:139362
Tanaka S; Saito Y; Kunisawa J; Kurashima Y; Wake T; Suzuki N; Shultz LD; Kiyono H; Ishikawa F. 2012. Development of mature and functional human myeloid subsets in hematopoietic stem cell-engrafted NOD/SCID/IL2rgammaKO mice.. In: . . MGI: J:188959
Thayer TC; Delano M; Liu C; Chen J; Padgett LE; Tse HM; Annamali M; Piganelli JD; Moldawer LL; Mathews CE. 2011. Superoxide production by macrophages and T cells is critical for the induction of autoreactivity and type 1 diabetes.. In: . . MGI: J:186804
The Jackson Laboratory. 2005. Information obtained from The Jackson Laboratory, Bar Harbor, ME. In: . . MGI: J:101977
Thomas DC; Mellanby RJ; Phillips JM; Cooke A. 2007. An early age-related increase in the frequency of CD4+ Foxp3+ cells in BDC2.5NOD mice.. In: . . MGI: J:125536
Todorova D; Kim J; Hamzeinejad S; He J; Xu Y. 2016. Brief Report: Immune Microenvironment Determines the Immunogenicity of Induced Pluripotent Stem Cell Derivatives.. In: . . MGI: J:233079
Touvrey C; Couedel C; Soulas P; Couderc R; Jasin M; de Villartay JP; Marche PN; Jouvin-Marche E; Candeias SM. 2008. Distinct effects of DNA-PKcs and Artemis inactivation on signal joint formation in vivo.. In: . . MGI: J:137712
Tremblay AM; Missiaglia E; Galli GG; Hettmer S; Urcia R; Carrara M; Judson RN; Thway K; Nadal G; Selfe JL; Murray G; Calogero RA; De Bari C; Zammit PS; Delorenzi M; Wagers AJ; Shipley J; Wackerhage H; Camargo FD. 2014. The Hippo transducer YAP1 transforms activated satellite cells and is a potent effector of embryonal rhabdomyosarcoma formation.. In: . . MGI: J:214602
Trowbridge JJ; Scott MP; Bhatia M. 2006. Hedgehog modulates cell cycle regulators in stem cells to control hematopoietic regeneration.. In: . . MGI: J:113717
Tsai S; Serra P; Clemente-Casares X; Slattery RM; Santamaria P. 2013. Dendritic cell-dependent in vivo generation of autoregulatory T cells by antidiabetogenic MHC class II.. In: . . MGI: J:205347
Tsai S; Shameli A; Yamanouchi J; Clemente-Casares X; Wang J; Serra P; Yang Y; Medarova Z; Moore A; Santamaria P. 2010. Reversal of autoimmunity by boosting memory-like autoregulatory T cells.. In: . . MGI: J:179859
Tsuchiya T; Fukuda S; Hamada H; Nakamura A; Kohama Y; Ishikawa H; Tsujikawa K; Yamamoto H. 2003. Role of gamma delta T cells in the inflammatory response of experimental colitis mice.. In: . . MGI: J:106734
Tsuji H; Ishii-Ohba H; Noda Y; Kubo E; Furuse T; Tatsumi K. 2009. Rag-dependent and Rag-independent mechanisms of Notch1 rearrangement in thymic lymphomas of Atm(-/-) and scid mice.. In: . . MGI: J:144042
Tsuji Y; Watanabe T; Kudo M; Arai H; Strober W; Chiba T. 2012. Sensing of Commensal Organisms by the Intracellular Sensor NOD1 Mediates Experimental Pancreatitis.. In: . . MGI: J:187368
Tucker TA; Kundert JA; Bondareva AA; Schmidt EE. 2005. Reproductive and neurological Quakingviable phenotypes in a severe combined immune deficient mouse background.. In: . . MGI: J:98496
Turley SJ; Lee JW; Dutton-Swain N; Mathis D; Benoist C. 2005. Endocrine self and gut non-self intersect in the pancreatic lymph nodes.. In: . . MGI: J:104385
Ueno S; Lu J; He J; Li A; Zhang X; Ritz J; Silberstein LE; Chai L. 2014. Aberrant expression of SALL4 in acute B cell lymphoblastic leukemia: mechanism, function, and implication for a potential novel therapeutic target.. In: . . MGI: J:215705
Uhlig HH; McKenzie BS; Hue S; Thompson C; Joyce-Shaikh B; Stepankova R; Robinson N; Buonocore S; Tlaskalova-Hogenova H; Cua DJ; Powrie F. 2006. Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology.. In: . . MGI: J:113470
Unsinger J; McDonough JS; Shultz LD; Ferguson TA; Hotchkiss RS. 2009. Sepsis-induced human lymphocyte apoptosis and cytokine production in 'humanized' mice.. In: . . MGI: J:151270
Van Buul PP; De Rooij DG; Zandman IM; Grigorova M; Van Duyn-Goedhart A. 1995. X-ray-induced chromosomal aberrations and cell killing in somatic and germ cells of the scid mouse.. In: . . MGI: J:26914
VanBuskirk KM; O'Neill MT; De La Vega P; Maier AG; Krzych U; Williams J; Dowler MG; Sacci JB Jr; Kangwanrangsan N; Tsuboi T; Kneteman NM; Heppner DG Jr; Murdock BA; Mikolajczak SA; Aly AS; Cowman AF; Kappe SH. 2009. Preerythrocytic, live-attenuated Plasmodium falciparum vaccine candidates by design.. In: . . MGI: J:152010
Vanner RJ; Remke M; Gallo M; Selvadurai HJ; Coutinho F; Lee L; Kushida M; Head R; Morrissy S; Zhu X; Aviv T; Voisin V; Clarke ID; Li Y; Mungall AJ; Moore RA; Ma Y; Jones SJ; Marra MA; Malkin D; Northcott PA; Kool M; Pfister SM; Bader G; Hochedlinger K; Korshunov A; Taylor MD; Dirks PB. 2014. Quiescent sox2(+) cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma.. In: . . MGI: J:213713
Vemuri MC; Schiller E; Naegele JR. 2001. Elevated DNA double strand breaks and apoptosis in the CNS of scid mutant mice.. In: . . MGI: J:115402
Verma-Gandhu M; Bercik P; Motomura Y; Verdu EF; Khan WI; Blennerhassett PA; Wang L; El-Sharkawy RT; Collins SM. 2006. CD4+ T-cell modulation of visceral nociception in mice.. In: . . MGI: J:124915
Viatour P; Ehmer U; Saddic LA; Dorrell C; Andersen JB; Lin C; Zmoos AF; Mazur PK; Schaffer BE; Ostermeier A; Vogel H; Sylvester KG; Thorgeirsson SS; Grompe M; Sage J. 2011. Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway.. In: . . MGI: J:177573
Viret C; Leung-Theung-Long S; Serre L; Lamare C; Vignali DA; Malissen B; Carrier A; Guerder S. 2011. Thymus-specific serine protease controls autoreactive CD4 T cell development and autoimmune diabetes in mice.. In: . . MGI: J:173941
Viriyakosol S; Matthias MA; Swancutt MA; Kirkland TN; Vinetz JM. 2006. Toll-like receptor 4 protects against lethal Leptospira interrogans serovar icterohaemorrhagiae infection and contributes to in vivo control of leptospiral burden.. In: . . MGI: J:105019
Volkmann A; Doffinger R; Ruther U; Kyewski BA. 1996. Insertional mutagenesis affecting programmed cell death leads to thymic hyperplasia and altered thymopoiesis.. In: . . MGI: J:108193
Vujanovic L; Szymkowski DE; Alber S; Watkins SC; Vujanovic NL; Butterfield LH. 2010. Virally infected and matured human dendritic cells activate natural killer cells via cooperative activity of plasma membrane-bound TNF and IL-15.. In: . . MGI: J:162797
Waldner H; Sobel RA; Price N; Kuchroo VK. 2006. The autoimmune diabetes locus Idd9 regulates development of type 1 diabetes by affecting the homing of islet-specific T cells.. In: . . MGI: J:131655
Walzer PD; Runck J; Steele P; White M; Linke MJ; Sidman CL. 1997. Immunodeficient and immunosuppressed mice as models to test anti-Pneumocystis carinii drugs.. In: . . MGI: J:39028
Wang C; Bogue MA; Levitt JM; Roth DB. 1999. Irradiation-mediated rescue of T cell-specific V(D)J recombination and thymocyte differentiation in severe combined immunodeficient mice by bone marrow cells.. In: . . MGI: J:115093
Wang GY; So PL; Wang L; Libove E; Wang J; Epstein EH Jr. 2011. Establishment of murine basal cell carcinoma allografts: a potential model for preclinical drug testing and for molecular analysis.. In: . . MGI: J:182174
Wang J; Cho S; Ueno A; Cheng L; Xu BY; Desrosiers MD; Shi Y; Yang Y. 2008. Ligand-dependent induction of noninflammatory dendritic cells by anergic invariant NKT cells minimizes autoimmune inflammation.. In: . . MGI: J:140188
Wang LX; Kang G; Kumar P; Lu W; Li Y; Zhou Y; Li Q; Wood C. 2014. Humanized-BLT mouse model of Kaposi's sarcoma-associated herpesvirus infection.. In: . . MGI: J:206819
Wang P; Rodriguez RT; Wang J; Ghodasara A; Kim SK. 2011. Targeting SOX17 in human embryonic stem cells creates unique strategies for isolating and analyzing developing endoderm.. In: . . MGI: J:171124
Wang Y; Sul HS. 2009. Pref-1 regulates mesenchymal cell commitment and differentiation through Sox9.. In: . . MGI: J:147095
Warner T; Balish E. 1995. Pulmonary alveolar proteinosis. A spontaneous and inducible disease in immunodeficient germ-free mice.. In: . . MGI: J:24415
Wecker H; Grusby MJ; Auchincloss H Jr. 1995. Effector cells must recognize antigens expressed in the graft to cause efficient skin graft rejection in SCID mice.. In: . . MGI: J:25110
Wei J; Wunderlich M; Fox C; Alvarez S; Cigudosa JC; Wilhelm JS; Zheng Y; Cancelas JA; Gu Y; Jansen M; Dimartino JF; Mulloy JC. 2008. Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia.. In: . . MGI: J:166360
Wei S; Kozono S; Kats L; Nechama M; Li W; Guarnerio J; Luo M; You MH; Yao Y; Kondo A; Hu H; Bozkurt G; Moerke NJ; Cao S; Reschke M; Chen CH; Rego EM; Lo-Coco F; Cantley LC; Lee TH; Wu H; Zhang Y; Pandolfi PP; Zhou XZ; Lu KP. 2015. Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer.. In: . . MGI: J:228245
Westwell-Roper C; Dai DL; Soukhatcheva G; Potter KJ; van Rooijen N; Ehses JA; Verchere CB. 2011. IL-1 blockade attenuates islet amyloid polypeptide-induced proinflammatory cytokine release and pancreatic islet graft dysfunction.. In: . . MGI: J:179268
White RE; Ramer PC; Naresh KN; Meixlsperger S; Pinaud L; Rooney C; Savoldo B; Coutinho R; Bodor C; Gribben J; Ibrahim HA; Bower M; Nourse JP; Gandhi MK; Middeldorp J; Cader FZ; Murray P; Munz C; Allday MJ. 2012. EBNA3B-deficient EBV promotes B cell lymphomagenesis in humanized mice and is found in human tumors.. In: . . MGI: J:184554
Wicklein D; Schmidt A; Labitzky V; Ullrich S; Valent P; Schumacher U. 2013. E- and p-selectins are essential for repopulation of chronic myelogenous and chronic eosinophilic leukemias in a scid mouse xenograft model.. In: . . MGI: J:204363
Wigginton JM; Lee JK; Wiltrout TA; Alvord WG; Hixon JA; Subleski J; Back TC; Wiltrout RH. 2002. Synergistic engagement of an ineffective endogenous anti-tumor immune response and induction of IFN-gamma and Fas-ligand-dependent tumor eradication by combined administration of IL-18 and IL-2.. In: . . MGI: J:109850
Wilkison M; Gauss K; Ran Y; Searles S; Taylor D; Meissner N. 2012. Type 1 interferons suppress accelerated osteoclastogenesis and prevent loss of bone mass during systemic inflammatory responses to pneumocystis lung infection.. In: . . MGI: J:185537
Willimann K; Matile H; Weiss NA; Imhof BA. 1995. In vivo sequestration of Plasmodium falciparum-infected human erythrocytes: a severe combined immunodeficiency mouse model for cerebral malaria.. In: . . MGI: J:28277
Winslow GM; Yager E; Shilo K; Collins DN; Chu FK. 1998. Infection of the laboratory mouse with the intracellular pathogen Ehrlichia chaffeensis.. In: . . MGI: J:48876
Wong FS; Du W; Thomas IJ; Wen L. 2005. The influence of the major histocompatibility complex on development of autoimmune diabetes in RIP-B7.1 mice.. In: . . MGI: J:109830
Woods NB; Bottero V; Schmidt M; von Kalle C; Verma IM. 2006. Gene therapy: therapeutic gene causing lymphoma.. In: . . MGI: J:108380
Wu T; Sun C; Chen Z; Zhen Y; Peng J; Qi Z; Yang X; Zhao Y. 2012. Smad3-deficient CD11b(+)Gr1(+) myeloid-derived suppressor cells prevent allograft rejection via the nitric oxide pathway.. In: . . MGI: J:190588
Wu X; Zhang W; Font-Burgada J; Palmer T; Hamil AS; Biswas SK; Poidinger M; Borcherding N; Xie Q; Ellies LG; Lytle NK; Wu LW; Fox RG; Yang J; Dowdy SF; Reya T; Karin M. 2014. Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade.. In: . . MGI: J:216379
Wunderlich M; Chou FS; Link KA; Mizukawa B; Perry RL; Carroll M; Mulloy JC. 2010. AML xenograft efficiency is significantly improved in NOD/SCID-IL2RG mice constitutively expressing human SCF, GM-CSF and IL-3.. In: . . MGI: J:166359
Xie J; Broxmeyer HE; Feng D; Schweitzer KS; Yi R; Cook TG; Chitteti BR; Barwinska D; Traktuev DO; Van Demark MJ; Justice MJ; Ou X; Srour EF; Prockop DJ; Petrache I; March KL. 2015. Human adipose-derived stem cells ameliorate cigarette smoke-induced murine myelosuppression via secretion of TSG-6.. In: . . MGI: J:223580
Xu L; Mohammad KS; Wu H; Crean C; Poteat B; Cheng Y; Cardoso AA; Machal C; Hanenberg H; Abonour R; Kacena MA; Chirgwin J; Suvannasankha A; Srour EF. 2016. Cell Adhesion Molecule CD166 Drives Malignant Progression and Osteolytic Disease in Multiple Myeloma.. In: . . MGI: J:237854
Xu W; Xin L; Soong L; Zhang K. 2011. Sphingolipid degradation by Leishmania major is required for its resistance to acidic pH in the mammalian host.. In: . . MGI: J:175272
XuFeng R; Boyer MJ; Shen H; Li Y; Yu H; Gao Y; Yang Q; Wang Q; Cheng T. 2009. ADAR1 is required for hematopoietic progenitor cell survival via RNA editing.. In: . . MGI: J:153698
Yahata T; Ando K; Nakamura Y; Ueyama Y; Shimamura K; Tamaoki N; Kato S; Hotta T. 2002. Functional human T lymphocyte development from cord blood CD34+ cells in nonobese diabetic/Shi-scid, IL-2 receptor gamma null mice.. In: . . MGI: J:77239
Yamasaki H; Sada A; Iwata T; Niwa T; Tomizawa M; Xanthopoulos KG; Koike T; Shiojiri N. 2006. Suppression of C/EBP{alpha} expression in periportal hepatoblasts may stimulate biliary cell differentiation through increased Hnf6 and Hnf1b expression.. In: . . MGI: J:114400
Yamashita J; Iwamura C; Ito T; Narita M; Hara Y; Sasaki T; Masuda D; Takahashi M; Tsuchiya M; Hada K; Ishikawa M; Matsuo T; Ohno Y; Tanaka H; Maruyama H; Ogawa Y; Nakayama T. 2013. Paraoxonase-1 suppresses experimental colitis via the inhibition of IFN-gamma production from CD4 T cells.. In: . . MGI: J:204816
Yan BS; Pichugin AV; Jobe O; Helming L; Eruslanov EB; Gutierrez-Pabello JA; Rojas M; Shebzukhov YV; Kobzik L; Kramnik I. 2007. Progression of pulmonary tuberculosis and efficiency of bacillus Calmette-Guerin vaccination are genetically controlled via a common sst1-mediated mechanism of innate immunity.. In: . . MGI: J:154010
Yang C; Loehn M; Jurczyk A; Przewozniak N; Leehy L; Herrera PL; Shultz LD; Greiner DL; Harlan DM; Bortell R. 2015. Lixisenatide accelerates restoration of normoglycemia and improves human beta-cell function and survival in diabetic immunodeficient NOD-scid IL-2rg(null) RIP-DTR mice engrafted with human islets.. In: . . MGI: J:225120
Yang GX; Wu Y; Tsukamoto H; Leung PS; Lian ZX; Rainbow DB; Hunter KM; Morris GA; Lyons PA; Peterson LB; Wicker LS; Gershwin ME; Ridgway WM. 2011. CD8 T cells mediate direct biliary ductule damage in nonobese diabetic autoimmune biliary disease.. In: . . MGI: J:168755
Yang L; Chen G; Mohanty S; Scott G; Fazal F; Rahman A; Begum S; Hynes RO; Xu L. 2011. GPR56 Regulates VEGF Production and Angiogenesis during Melanoma Progression.. In: . . MGI: J:175446
Yang L; Friedland S; Corson N; Xu L. 2014. GPR56 inhibits melanoma growth by internalizing and degrading its ligand TG2.. In: . . MGI: J:208172
Yang PL; Althage A; Chung J; Maier H; Wieland S; Isogawa M; Chisari FV. 2010. Immune effectors required for hepatitis B virus clearance.. In: . . MGI: J:156523
Yang X; Zhang Y; Yang Y; Lim S; Cao Z; Rak J; Cao Y. 2013. Vascular endothelial growth factor-dependent spatiotemporal dual roles of placental growth factor in modulation of angiogenesis and tumor growth.. In: . . MGI: J:200676
Yang YG; Chen AM; Garrett LJ; Sergio JJ; Theodore P; Awwad M; VerHalen J; Bodine DM; Sachs DH; Sykes M. 2000. Development and analysis of transgenic mice expressing porcine hematopoietic cytokines: a model for achieving durable porcine hematopoietic chimerism across an extensive xenogeneic barrier.. In: . . MGI: J:94302
Yasuda A; Tsuji O; Shibata S; Nori S; Takano M; Kobayashi Y; Takahashi Y; Fujiyoshi K; Hara CM; Miyawaki A; Okano HJ; Toyama Y; Nakamura M; Okano H. 2011. Significance of remyelination by neural stem/progenitor cells transplanted into the injured spinal cord.. In: . . MGI: J:190194
Yasutomo K; Maeda K; Hisaeda H; Good RA; Kuroda Y; Himeno K. 1997. The Fas-deficient SCID mouse exhibits the development of T cells in the thymus.. In: . . MGI: J:40207
Yeh ES; Lew BO; Means AR. 2006. The loss of PIN1 deregulates cyclin E and sensitizes mouse embryo fibroblasts to genomic instability.. In: . . MGI: J:105781
Yi S; Ji M; Wu J; Ma X; Phillips P; Hawthorne WJ; O'Connell PJ. 2012. Adoptive transfer with in vitro expanded human regulatory T cells protects against porcine islet xenograft rejection via interleukin-10 in humanized mice.. In: . . MGI: J:196728
Yi Z; Diz R; Martin AJ; Morillon YM; Kline DE; Li L; Wang B; Tisch R. 2012. Long-term remission of diabetes in NOD mice is induced by nondepleting anti-CD4 and anti-CD8 antibodies.. In: . . MGI: J:208520
Yi Z; Li L; Garland A; He Q; Wang H; Katz JD; Tisch R; Wang B. 2012. IFN-gamma receptor deficiency prevents diabetes induction by diabetogenic CD4+, but not CD8+, T cells.. In: . . MGI: J:187880
Yoshida K; van den Berg TK; Dijkstra CD. 1994. The functional state of follicular dendritic cells in severe combined immunodeficient (SCID) mice: role of the lymphocytes.. In: . . MGI: J:16866
Yoshioka T; Otero J; Chen Y; Kim YM; Koutcher JA; Satagopan J; Reuter V; Carver B; de Stanchina E; Enomoto K; Greenberg NM; Scardino PT; Scher HI; Sawyers CL; Giancotti FG. 2013. beta4 Integrin signaling induces expansion of prostate tumor progenitors.. In: . . MGI: J:194482
Yoshizawa M; Okada T; Morikawa Y; Sasaki F; Kiso Y. 1994. Murine granulated metrial gland cell population in beige (bg/bg) and SCID (scid/scid) genotypes.. In: . . MGI: J:21177
Young D; Kearney JF. 1995. Sequence analysis and antigen binding characteristics of Ig SCID Ig+ mice.. In: . . MGI: J:25547
Yui MA; Rothenberg EV. 2004. Deranged early T cell development in immunodeficient strains of nonobese diabetic mice.. In: . . MGI: J:132809
Zane NA; Gundelach JH; Lindquist LD; Bram RJ. 2012. Essential role for CAML in follicular B cell survival and homeostasis.. In: . . MGI: J:183110
Zare F; Bokarewa M; Nenonen N; Bergstrom T; Alexopoulou L; Flavell RA; Tarkowski A. 2004. Arthritogenic properties of double-stranded (viral) RNA.. In: . . MGI: J:89689
Zavidij O; Ball CR; Herbst F; Fessler S; Schmidt M; von Kalle C; Glimm H. 2010. Hematopoietic activity of human short-term repopulating cells in mobilized peripheral blood cell transplants is restricted to the first 5 months after transplantation.. In: . . MGI: J:161539
Zhang B; Strauss AC; Chu S; Li M; Ho Y; Shiang KD; Snyder DS; Huettner CS; Shultz L; Holyoake T; Bhatia R. 2010. Effective targeting of quiescent chronic myelogenous leukemia stem cells by histone deacetylase inhibitors in combination with imatinib mesylate.. In: . . MGI: J:160523
Zhang C; Cui Y; Houston S; Chang LJ. 1996. Protective immunity to HIV-1 in SCID/beige mice reconstituted with peripheral blood lymphocytes of exposed but uninfected individuals.. In: . . MGI: J:37253
Zhang H; Hilton MJ; Anolik JH; Welle SL; Zhao C; Yao Z; Li X; Wang Z; Boyce BF; Xing L. 2014. NOTCH inhibits osteoblast formation in inflammatory arthritis via noncanonical NF-kappaB.. In: . . MGI: J:213803
Zhang H; Watanabe R; Berry GJ; Vaglio A; Liao YJ; Warrington KJ; Goronzy JJ; Weyand CM. 2017. Immunoinhibitory checkpoint deficiency in medium and large vessel vasculitis.. In: . . MGI: J:240876
Zhang H; Zhou X; McQuade T; Li J; Chan FK; Zhang J. 2011. Functional complementation between FADD and RIP1 in embryos and lymphocytes.. In: . . MGI: J:170816
Zhang JQ; Okumura C; McCarty T; Shin MS; Mukhopadhyay P; Hori M; Torrey TA; Naghashfar Z; Zhou JX; Lee CH; Roopenian DC; Morse HC 3rd; Davidson WF. 2004. Evidence for selective transformation of autoreactive immature plasma cells in mice deficient in Fasl.. In: . . MGI: J:94696
Zhang Q; Hossain DM; Duttagupta P; Moreira D; Zhao X; Won H; Buettner R; Nechaev S; Majka M; Zhang B; Cai Q; Swiderski P; Kuo YH; Forman S; Marcucci G; Kortylewski M. 2016. Serum-resistant CpG-STAT3 decoy for targeting survival and immune checkpoint signaling in acute myeloid leukemia.. In: . . MGI: J:232638
Zhang S; Yajima H; Huynh H; Zheng J; Callen E; Chen HT; Wong N; Bunting S; Lin YF; Li M; Lee KJ; Story M; Gapud E; Sleckman BP; Nussenzweig A; Zhang CC; Chen DJ; Chen BP. 2011. Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair.. In: . . MGI: J:171351
Zhang X; Wan G; Mlotshwa S; Vance V; Berger FG; Chen H; Lu X. 2010. Oncogenic Wip1 phosphatase is inhibited by miR-16 in the DNA damage signaling pathway.. In: . . MGI: J:164245
Zhang YW; Su Y; Lanning N; Gustafson M; Shinomiya N; Zhao P; Cao B; Tsarfaty G; Wang LM; Hay R; Vande Woude GF. 2005. Enhanced growth of human met-expressing xenografts in a new strain of immunocompromised mice transgenic for human hepatocyte growth factor/scatter factor.. In: . . MGI: J:239806
Zhao C; Marrero I; Narsale A; Moya R; Davies JD. 2015. CD4(+) CD44(v.low) cells are unique peripheral precursors that are distinct from recent thymic emigrants and stem cell-like memory cells.. In: . . MGI: J:229768
Zhao Y; Guo C; Hwang D; Lin B; Dingeldein M; Mihailescu D; Sam S; Sidhwani S; Zhang Y; Jain S; Skidgel RA; Prabhakar BS; Mazzone T; Holterman MJ. 2010. Selective destruction of mouse islet beta cells by human T lymphocytes in a newly-established humanized type 1 diabetic model.. In: . . MGI: J:164900
Zheng CF; Guan KL. 1993. Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2.. In: . . MGI: J:31929
Zheng M; Ramsay AJ; Robichaux MB; Norris KA; Kliment C; Crowe C; Rapaka RR; Steele C; McAllister F; Shellito JE; Marrero L; Schwarzenberger P; Zhong Q; Kolls JK. 2005. CD4+ T cell-independent DNA vaccination against opportunistic infections.. In: . . MGI: J:104584
Zhou P; Szot GL; Guo Z; Kim O; He G; Wang J; Grusby MJ; Newell KA; Thistlethwaite JR; Bluestone JA; Alegre ML. 2000. Role of STAT4 and STAT6 signaling in allograft rejection and CTLA4-Ig-mediated tolerance.. In: . . MGI: J:119580
Zhu C; Roth DB. 1995. Characterization of coding ends in thymocytes of scid mice: implications for the mechanism of V(D)J recombination.. In: . . MGI: J:28349
de Laval B; Pawlikowska P; Petit-Cocault L; Bilhou-Nabera C; Aubin-Houzelstein G; Souyri M; Pouzoulet F; Gaudry M; Porteu F. 2013. Thrombopoietin-increased DNA-PK-dependent DNA repair limits hematopoietic stem and progenitor cell mutagenesis in response to DNA damage.. In: . . MGI: J:194947
de Oliveira VL; Keijsers RR; van de Kerkhof PC; Seyger MM; Fasse E; Svensson L; Latta M; Norsgaard H; Labuda T; Hupkens P; van Erp PE; Joosten I; Koenen HJ. 2012. Humanized mouse model of skin inflammation is characterized by disturbed keratinocyte differentiation and influx of IL-17A producing T cells.. In: . . MGI: J:192181
van Buul PP; Abramsson-Zetterberg L; Zandman IM; van Duyn-Goedhart A. 1998. Further characterization of the radiosensitivity of the scid mouse.. In: . . MGI: J:115137
van Essen D; Dullforce P; Gray D. 2000. Role of B cells in maintaining helper T-cell memory.. In: . . MGI: J:106317
van Rossum AM; Lysenko ES; Weiser JN. 2005. Host and bacterial factors contributing to the clearance of colonization by Streptococcus pneumoniae in a murine model.. In: . . MGI: J:104292
van den Pol AN. 2009. Brain trauma enhances transient cytomegalovirus invasion of the brain only in mice that are immunodeficient.. In: . . MGI: J:153392
van der Touw W; Cravedi P; Kwan WH; Paz-Artal E; Merad M; Heeger PS. 2013. Cutting edge: Receptors for C3a and C5a modulate stability of alloantigen-reactive induced regulatory T cells.. In: . . MGI: J:204834
von Herrath MG; Dockter J; Oldstone MB. 1994. How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model.. In: . . MGI: J:81287

Additional - Tg(HLA-A/H2-D/B2M)1Dvs related

Chen X; Tang Y; Zhang Y; Zhuo M; Tang Z; Yu Y; Zang G. 2014. Tapasin modification on the intracellular epitope HBcAg18-27 enhances HBV-specific CTL immune response and inhibits hepatitis B virus replication in vivo.. In: . . MGI: J:208402
Enee E; Martinuzzi E; Blancou P; Bach JM; Mallone R; van Endert P. 2008. Equivalent specificity of peripheral blood and islet-infiltrating CD8+ T lymphocytes in spontaneously diabetic HLA-A2 transgenic NOD mice.. In: . . MGI: J:134255
Jaiswal S; Pearson T; Friberg H; Shultz LD; Greiner DL; Rothman AL; Mathew A. 2009. Dengue virus infection and virus-specific HLA-A2 restricted immune responses in humanized NOD-scid IL2rgammanull mice.. In: . . MGI: J:154110
Jarchum I; Baker JC; Yamada T; Takaki T; Marron MP; Serreze DV; DiLorenzo TP. 2007. In vivo cytotoxicity of insulin-specific CD8+ T-cells in HLA-A*0201 transgenic NOD mice.. In: . . MGI: J:126569
Jarchum I; DiLorenzo TP. 2010. Ins2 deficiency augments spontaneous HLA-A*0201-restricted T cell responses to insulin.. In: . . MGI: J:159429
Niens M; Grier AE; Marron M; Kay TW; Greiner DL; Serreze DV. 2011. Prevention of 'Humanized' diabetogenic CD8 T-cell responses in HLA-transgenic NOD mice by a multipeptide coupled-cell approach.. In: . . MGI: J:171756
Serreze DV; Marron MP; Dilorenzo TP. 2007. 'Humanized' HLA transgenic NOD mice to identify pancreatic beta cell autoantigens of potential clinical relevance to type 1 diabetes.. In: . . MGI: J:123948
Shultz LD; Saito Y; Najima Y; Tanaka S; Ochi T; Tomizawa M; Doi T; Sone A; Suzuki N; Fujiwara H; Yasukawa M; Ishikawa F. 2010. Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2r gamma(null) humanized mice.. In: . . MGI: J:162315
Tsai S; Shameli A; Yamanouchi J; Clemente-Casares X; Wang J; Serra P; Yang Y; Medarova Z; Moore A; Santamaria P. 2010. Reversal of autoimmunity by boosting memory-like autoregulatory T cells.. In: . . MGI: J:179859
Whitfield-Larry F; Young EF; Talmage G; Fudge E; Azam A; Patel S; Largay J; Byrd W; Buse J; Calikoglu AS; Shultz LD; Frelinger JA. 2011. HLA-A2-matched peripheral blood mononuclear cells from type 1 diabetic patients, but not nondiabetic donors, transfer insulitis to NOD-scid/gammac(null)/HLA-A2 transgenic mice concurrent with the expansion of islet-specific CD8+ T cells.. In: . . MGI: J:177952

Also Known As: NOD.scid HHD

Donating Investigator

Genetic overview

Research Applications

Base Price

Detailed Description

Development

Expression Data

Control Suggestions

Additional Information

Selected References

Emv30b

Allele Symbol: Emv30b

Prkdcscid

Allele Symbol: Prkdcscid

Tg(HLA-A/H2-D/B2M)1Dvs

Allele Symbol: Tg(HLA-A/H2-D/B2M)1Dvs

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: Prkdcscid related

References

Additional References

Additional - Emv30b related

Additional - Prkdcscid related

Additional - Tg(HLA-A/H2-D/B2M)1Dvs related

Genotyping Protocols

Appearance

Citation

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200

Live Mouse

Cryorecovery - Pricing

Related Products and Services

Payment Terms and Conditions

The Jackson Laboratory's Genotype Promise

Terms of Use

Licensing Information

JAX® Mice, Products & Services Conditions of Use

No Warranty

Credit for PRODUCTS or SERVICES

Animal Care and Use for SERVICES

No Liability

Emv30^b

Allele Symbol: Emv30^b

Prkdc^scid

Allele Symbol: Prkdc^scid

Genotype: Prkdc^scid related

Additional - Emv30^b related

Additional - Prkdc^scid related