The Tsed spontaneous mutation causes polydactyly of all four paws and twisting of the hind legs.
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous | Tsed | twisted legs and extra digits |
Mice carrying the Tsed mutation have significant polydactyly on all four feet and some display twisted hind legs, which often orient inward toward the body with varying degrees of severity. Homozygotes are viable and fertile. When outcrossed to BALB/cByJ the heterozygous offspring show incomplete penetrance.
The Tsed mutation was first identified by Norman Hawes in a segregating stock containing C57BL/6J, an undefined 129 inbred, and CAST/EiJ. This mutant subline has been maintained by sibling inbreeding mutants ever since and became homozygous for Tsed. In 2012 this homozygous line reached generation F26.
When using the STOCK Tsed/GrsrJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #006425 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous |
Frozen Mouse Embryo | STOCK Tsed/GrsrJ Frozen Embryo | $2595.00 |
Frozen Mouse Embryo | STOCK Tsed/GrsrJ Frozen Embryo | $2595.00 |
Frozen Mouse Embryo | STOCK Tsed/GrsrJ Frozen Embryo | $3373.50 |
Frozen Mouse Embryo | STOCK Tsed/GrsrJ Frozen Embryo | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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