STOCK Tsed/GrsrJ

Stock number: 006425

Description

The Tsed spontaneous mutation causes polydactyly of all four paws and twisting of the hind legs.

Detailed description

Mice carrying the Tsed mutation have significant polydactyly on all four feet and some display twisted hind legs, which often orient inward toward the body with varying degrees of severity. Homozygotes are viable and fertile. When outcrossed to BALB/cByJ the heterozygous offspring show incomplete penetrance.

Development

The Tsed mutation was first identified by Norman Hawes in a segregating stock containing C57BL/6J, an undefined 129 inbred, and CAST/EiJ. This mutant subline has been maintained by sibling inbreeding mutants ever since and became homozygous for Tsed. In 2012 this homozygous line reached generation F26.

Allele

Symbol: Tsed
Name: twisted legs and extra digits
MGI accession ID: MGI:3845084
Generation method: Spontaneous
Marker symbol: Tsed
Marker name: twisted legs and extra digits
Chromosome: 5
Strain of origin: 129 and C57BL/6J and CAST/EiJ