Mice carrying the Tsed mutation have significant polydactyly on all four feet and some display twisted hind legs, which often orient inward toward the body with varying degrees of severity. Homozygotes are viable and fertile. When outcrossed to BALB/cByJ the heterozygous offspring show incomplete penetrance.
The Tsed mutation was first identified by Norman Hawes in a segregating stock containing C57BL/6J, an undefined 129 inbred, and CAST/EiJ. This mutant subline has been maintained by sibling inbreeding mutants ever since and became homozygous for Tsed. In 2012 this homozygous line reached generation F26.
When using the STOCK Tsed/GrsrJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #006425 in your Materials and Methods section.