These mice carry a spontaneous mutation resulting in small body size, gait instability and shortened life span.
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous | Dab1 | disabled 1 |
By 2 weeks of age, mice homozygous for the scrambler 3 Jackson mutation are smaller than their littermates and ataxic with a severely unstable gait and inability to right themselves. They rarely survive beyond 3 weeks of age, although heterozygotes have a normal lifespan. Histology of homozygotes shows disorganization of the hippocampal layers and a lack of cerebellar folia. The scrambler 3 Jackson mutation causes a more severe phenotype than does the scrambler 2 Jackson mutation.
The scrambler 3 Jackson mutation arose spontaneously in the F2 offspring of a linkage cross of B6.CAST-Cdh23Ahl+/Kjn and B6.129S7-Sod1tm1Leb/DnJ and was backcrossed twice to C57BL/6J before being maintained by sibling intercrossing homozygous ovarian transplant hosts with heterozygous males. The targeted mutation has been bred out of this mutant subline.
Allele Name | scrambler 3 Jackson |
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Allele Type | Spontaneous |
Allele Synonym(s) | |
Gene Symbol and Name | Dab1, disabled 1 |
Gene Synonym(s) | |
Strain of Origin | (B6.CAST-Cdh23+/Kjn x B6.129S7-Sod1tm1Leb/DnJ)F2 |
Chromosome | 4 |
Molecular Note | This spontaneous mutation arose spontaneously at The Jackson Laboratory and was proven allelic with the original scrambler mutation by failed complementation. |
When using the scrambler(3J) mouse strain in a publication, please cite the originating article(s) and include JAX stock #006408 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Progeny testing required but not provided. No genotyping assay is available for these recessive cryo-recovered animals of undefined genotype |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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