By 2 weeks of age, mice homozygous for the scrambler 3 Jackson mutation are smaller than their littermates and ataxic with a severely unstable gait and inability to right themselves.  They rarely survive beyond 3 weeks of age, although heterozygotes have a normal lifespan.  Histology of homozygotes shows disorganization of the hippocampal layers and a lack of cerebellar folia. The scrambler 3 Jackson mutation causes a more severe phenotype than does the scrambler 2 Jackson mutation.

These mice carry a spontaneous mutation resulting in small body size, gait instability and shortened life span.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

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