These Rims1 knock-in mice were developed to study presynaptic proteins involved in neurotransmitter release in the CNS.
Dr. Thomas C. Sudhof, Stanford University School of Medicine
Homozygotes are viable and fertile and do not display any gross physical or behavioral abnormalities. No overt phenotype has been observed.
|Allele Name||targeted mutation 2, Thomas C Sudhof|
|Allele Type||Targeted (Not Applicable)|
|Allele Synonym(s)||RIM1 S413A-KI|
|Gene Symbol and Name||Rims1, regulating synaptic membrane exocytosis 1|
|Promoter||Rims1, regulating synaptic membrane exocytosis 1, mouse, laboratory|
|Strain of Origin||(129X1/SvJ x 129S1/Sv)F1-Kitl+|
|Molecular Note||Exon 6 was replaced with one in which nucleotide substitutions result in an amino acid substitution of alanine for serine at position 413 (S413A). A loxP site was inserted upstream of the modified exon 6 and an frt-flanked, double neo cassette with a 5' loxP site was inserted downstream of exon 6 and removed by germ line, flp mediated recombination.|
|Mutations Made By|| |
Dr. Thomas Sudhof, Stanford University School of Medicine
When maintained as a live colony heterozygotes or homozygotes may be used for breeding.
When using the RIM1 alpha S413A KI mouse strain in a publication, please cite the originating article(s) and include JAX stock #006384 in your Materials and Methods section.