B6;129-Rims1^tm2Sud/J

Stock number: 006384
Product name: RIM1 alpha S413A KI
Research areas: Neurobiology Research

Description

These Rims1 knock-in mice were developed to study presynaptic proteins involved in neurotransmitter release in the CNS.

Detailed description

Homozygotes are viable and fertile and do not display any gross physical or behavioral abnormalities. No overt phenotype has been observed.

Allele

Symbol: Rims1^tm2Sud
Name: targeted mutation 2, Thomas C Sudhof
MGI accession ID: MGI:3693318
Generation method: Targeted
Attributes: Not Applicable
Marker symbol: Rims1
Marker name: regulating synaptic membrane exocytosis 1
Chromosome: 1
Strain of origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺
Molecular note: Exon 6 was replaced with one in which nucleotide substitutions result in an amino acid substitution of alanine for serine at position 413 (S413A). A loxP site was inserted upstream of the modified exon 6 and an frt-flanked, double neo cassette with a 5' loxP site was inserted downstream of exon 6 and removed by germ line, flp mediated recombination.