These Rims1 knock-in mice were developed to study presynaptic proteins involved in neurotransmitter release in the CNS.
Dr. Thomas C. Sudhof, Stanford University School of Medicine
Genetic Background | Generation |
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|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Targeted (Not Applicable) | Rims1 | regulating synaptic membrane exocytosis 1 |
Homozygotes are viable and fertile and do not display any gross physical or behavioral abnormalities. No overt phenotype has been observed.
Allele Name | targeted mutation 2, Thomas C Sudhof |
---|---|
Allele Type | Targeted (Not Applicable) |
Allele Synonym(s) | RIM1 S413A-KI |
Gene Symbol and Name | Rims1, regulating synaptic membrane exocytosis 1 |
Gene Synonym(s) | |
Promoter | Rims1, regulating synaptic membrane exocytosis 1, mouse, laboratory |
Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl+ |
Chromosome | 1 |
Molecular Note | Exon 6 was replaced with one in which nucleotide substitutions result in an amino acid substitution of alanine for serine at position 413 (S413A). A loxP site was inserted upstream of the modified exon 6 and an frt-flanked, double neo cassette with a 5' loxP site was inserted downstream of exon 6 and removed by germ line, flp mediated recombination. |
Mutations Made By | Dr. Thomas Sudhof, Stanford University School of Medicine |
When maintained as a live colony heterozygotes or homozygotes may be used for breeding.
When using the RIM1 alpha S413A KI mouse strain in a publication, please cite the originating article(s) and include JAX stock #006384 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous or Wild-type for Rims1<tm2Sud> |
Frozen Mouse Embryo | B6;129-Rims1<tm2Sud>/J Frozen Embryo | $2595.00 |
Frozen Mouse Embryo | B6;129-Rims1<tm2Sud>/J Frozen Embryo | $2595.00 |
Frozen Mouse Embryo | B6;129-Rims1<tm2Sud>/J Frozen Embryo | $3373.50 |
Frozen Mouse Embryo | B6;129-Rims1<tm2Sud>/J Frozen Embryo | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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