Mice homozygous for this targeted mutation die shortly after birth. Heterozygotes suffer no apparent morbidity or premature mortality. Newborn homozygotes exhibit a rounded appearance with a shoulder hump that may be caused by excess brown fat in the upper back. No developmental changes were noted. Analysis of brain sections did not detect any abnormalities or neurodegeneration. No changes are observed in the expression of a series of synaptic proteins. Spontaneous synaptic vesicle fusion and fusion induced by hypertonic sucrose are decreased approximately 10-fold, and fast Ca<sup>2+</sup>-triggered fusion was decreased more than 100-fold. No protein product from the targeted gene is detected in forebrain tissue. This mutant mouse strain represents a model that may be useful in studies of synaptic fusion mechanisms. 

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Homozygous vesicle-associated membrane protein 2 (formerly synaptobrevin 2) KO mice show decreased synaptic vesicle fusion and die shortly after birth.

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