Mice homozygous for this targeted mutation are viable and fertile, but are poor breeders. Morphological analyses of the brain failed to uncover structural abnormalities or changes in brain architecture. Protein product from the targeted gene is not detected in brain tissue. No statistically significant difference in the density and size of synapses, synaptic vesicle density, or number of docked vesicles has been detected. Decreased transmitter release during paired stimulations was found at inhibitory synapses, opposite to an increase at excitatory synapses. Post-tetanic potentiation (short-term plasticity) is strongly enhanced. This mutant mouse strain represents a model that may be useful in studies of neurotransmitter release. 

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These <i>Rims1</i> knock-out mice exhibit decreased transmitter release at inhibitory synapses and an increase at excitatory synapses. They may be useful in studies relating to neurotransmission.

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