C57BL/6J-Chr 2^C3H/HeJ/J

Stock number: 006357
Product name: B6.C3-Chr2
Research areas: Research Tools

Description

This congenic strain carries a recessive susceptibility allele (Ctrq-1) at the C. trachomatis resistance QTL on Chromosome 2 from the C3H/HeJ strain.

Detailed description

A chromosome substitution or consomic strain is an inbred strain with one of its chromosomes replaced by the homologous chromosome of another inbred strain. The C57BL/6J and C3H/HeJ inbred strains were selected for this consomic because they differ in their susceptibility to infectious disease, specifically Chlamydia trachomatis. Consomic strains can accelerate quantitative trait loci identification and mapping.

Development

Drs. Michael Starnbach and Isaac Bernstein-Hanley from Harvard Medical School developed this consomic by replacing Chromosome 2 from the C3H/HeJ donor strain into the C57BL/6J host strain using a marker-assisted series of backcrosses. The set was donated to The Jackson Laboratory in 2006.