The inbred strain LT carries the spontaneous coat color mutation light (Tyrp1B-lt). Females exhibit oocyte metaphase I arrest (a result of prolonged spindle assembly checkpoint activity), parthenogenesis, embryonic triploidy and ovarian teratomas.
Eva Eicher, The Jackson Laboratory
LT is an inbred strain derived from a C58 mouse, which was outcrossed to BALB/c. LT carries the spontaneous coat color mutation light (B-lt), an arginine to cysteine substitution in tyrosinase-related protein 1 (Tyrp1). LT mice are characterized by a white hair shaft, brown hair tips and pigment dispersion in the iris of the eye. Approximately half of all females develop ovarian teratomas. Poor reproductive success in LT females is attributable to abnormalities in oocyte meiotic cell-cycle (specifically in the spindle assembly checkpoint), spontaneous parthenogenetic activation of oocytes, and the occasional occurrence of digynic triploidy.
This inbred strain began as a spontaneous mutation described as light (B-lt), it was discovered in a C58 colony by Dr. E. C. MacDowell in 1950. The affected light mouse was crossed to BALB and brother x sister mated for 7 generations. The colony was then transferred to Dr. Herman Chase and reached F28 by 1957. Chase sent the mice to Dr. E. S. Russell at The Jackson Laboratory in 1957. From Russell, the colony was transferred to Dr. S. E. Bernstein and in 1971 transferred to Dr. Leroy Stevens at the F75 (Stevens LC, et al., 1974 J:25361). Dr. Eva Eicher took over the colony from Dr. Stevens. It was imported into The Jackson Laboratory Repository in 2006.
Allele Name | light |
---|---|
Allele Type | Spontaneous |
Allele Synonym(s) | |
Gene Symbol and Name | Tyrp1, tyrosinase-related protein 1 |
Gene Synonym(s) | |
Strain of Origin | C58 |
Chromosome | 4 |
Molecular Note | A C-to-T transition at coding nucleotide 112 is predicted to result in an arginine to cysteine substitition at codon 38 (p.R38C). |
This strain is susceptible to kidney disease and the females are prone to ovarian teratomas. Replace breeder pair after their fourth litter.
When using the LT/SvEiJ mouse strain in a publication, please include JAX stock #006252 in your Materials and Methods section.
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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