Mice homozygous for the sunken mutation are small and have severe kyphosis with the abdomen appearing sunken in.
The sunken mutation arose spontaneously in 2003 in the A/J inbred colony of the Mouse Mutant Resource at The Jackson Laboratory and has been maintained on this inbred background ever since via sibling inbreeding with an occasional backcross to A/J.
|Gene Symbol and Name||Samd4, sterile alpha motif domain containing 4|
|Strain of Origin||A/J|
|Molecular Note||This spontaneous deletion begins at Chromosome 14 position 46,882,442 bp and extends through position 46,884,938 bp (GRCm38), and is predicted to remove the 5-prime UTR, exon 1, and a portion of exon 2 including the start codon.|