JAX
Mouse Strain Datasheet - 006245
C.Cg-Tg(SFTPC-rtTA)5Jaw/J
Also Known As: Sp-c-rtTA
Expression of rtTA in these transgenic mice is driven by the human SFTPC promoter and detected in lung peripheral epithelial cells from adult mice and in embryos.
Donating Investigator
IMR Colony, The Jackson Laboratory
Genetic overview
| Genetic Background | Generation |
|---|---|
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Tg(SFTPC-rtTA)5Jaw
| Allele Type |
|---|
| Transgenic (Transactivator) |
Research Applications
- Developmental Biology Research
- Immunology, Inflammation and Autoimmunity Research
- Internal/Organ Research
- Research Tools
Detailed Description
Hemizygous transgenic mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities. These transgenic mice express the reverse tetracycline-controlled transactivator (rtTA) protein under the control of the human SFTPC, surfactant, pulmonary-associated protein C, promoter. rtTA activity is detected in lung peripheral epithelial cells from adult mice and in embryos from pregnant females treated with the tetracycline analog, doxycycline (dox). In the latter, rtTA-induced expression of a luciferase reporter under the regulation of a tetracycline-responsive promoter (TRE; tetO) has been detected as early as embryonic day 10.5. When hemizygotes are mated to a second transgenic strain carrying a gene of interest under the regulatory control of a TRE, expression of the target gene in the bitransgenic offspring may be regulated by dox; in the presence of dox, transcription of the target gene is induced in cells where rtTA is expressed. This strain provides a "Tet-On" tool that allows the inducible expression of genes in the developing and adult lung and respiratory epithelium. Please note that some level of rtTA expression may be present in lung tissue from mice untreated with dox.
In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles frequently are moved to a genetic background different from that on which an allele was first characterized. This is the case for this strain. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.
Development
A transgenic construct containing 3.7kb sequence of the human SFTPC, surfactant, pulmonary-associated protein C, gene promoter, the reverse tetracycline regulatable transactivator protein (rtTA) gene, and SV40 polyadenylation signal sequence was injected into mixed C57BL/6 and 129 background embryos. Founder mice were bred to FVB/N animals. Upon arrival at The Jackson Laboratory, these mice were backcrossed to BALB/cJ mice for at least 5 generations
Expression Data
| Expressed Gene | rtTA, reverse tetracycline-controlled transactivator, E. coli |
|---|---|
| Site of Expression | Expresses rtTA in developing and adult lung. |
Control Suggestions
Selected References
- Tichelaar JW; Lu W; Whitsett JA. 2000. Conditional expression of fibroblast growth factor-7 in the developing and mature lung. J Biol Chem 275(16):11858-64. PubMed: 10766812MGI: J:61736
Tg(SFTPC-rtTA)5Jaw
Allele Symbol: Tg(SFTPC-rtTA)5Jaw
| Allele Name | transgene insertion 5, Jeffrey A Whitsett |
|---|---|
| Allele Type | Transgenic (Transactivator) |
| Allele Synonym(s) | SFTPC-rtTA; SP-C-rtTA mice (Line 1); SP-C-rtTAtg; SP-CrtTA; SP-CrtTAtg; SPC-rtTA; Sp-c-rtta; Tg(SFTPC-rtTA)1Jaw; hSPC-rtTA+ |
| Gene Symbol and Name | Tg(SFTPC-rtTA)5Jaw, transgene insertion 5, Jeffrey A Whitsett |
| Gene Synonym(s) | SP-C-rtTAtg; SP-CrtTA; SP-CrtTAtg; SPC-rtTA; Sp-c-rtta; Tg(SFTPC-rtTA)1Jaw; Tg(SFTPC-rtTA)1Jaw; hSPC-rtTA+; transgene insertion 1, Jeffrey A Whitsett |
| Promoter | SFTPC, surfactant protein C, human |
| Expressed Gene | rtTA, reverse tetracycline-controlled transactivator, E. coli |
| Site of Expression | Expresses rtTA in developing and adult lung. |
| Strain of Origin | Not Specified |
| Chromosome | UN |
| Molecular Note | The transgene is composed of 3.7 kb of human SFTPC promoter, a reverse tetracycline responsive transactivator gene (rt-TA), and a 0.45 kb SV40 polyadenylation signal. Transgene expression was confirmed by RT-PCR analysis. The human SFTPC promoter is active in respiratory epithelial cells. |
| Mutations Made By | Dr. Jeffrey Whitsett, Children's Hospital Medical Center |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Developmental Biology Research
- Internal/Organ Defects
- lung
- Internal/Organ Defects
- Immunology, Inflammation and Autoimmunity Research
- Cystic Fibrosis
- Internal/Organ Research
- Lung Defects
- Research Tools
- Cancer Research
- Tetop Tet System
- Developmental Biology Research
- Genetics Research
- Mutagenesis and Transgenesis
- Mutagenesis and Transgenesis: Tetop Tet System
- Immunology, Inflammation and Autoimmunity Research
- Internal/Organ Research
- Tet Expression Systems
- tTA/rtTA Expressing Strains
- Cancer Research
References
- Tichelaar JW; Lu W; Whitsett JA. 2000. Conditional expression of fibroblast growth factor-7 in the developing and mature lung. J Biol Chem 275(16):11858-64. PubMed: 10766812MGI: J:61736
Additional - Tg(SFTPC-rtTA)5Jaw related
- Akeson AL; Greenberg JM; Cameron JE; Thompson FY; Brooks SK; Wiginton D; Whitsett JA. 2003. Temporal and spatial regulation of VEGF-A controls vascular patterning in the embryonic lung. Dev Biol 264(2):443-55. PubMed: 14651929MGI: J:86840
- Allen TD; Zhu CQ; Jones KD; Yanagawa N; Tsao MS; Bishop JM. 2011. Interaction between MYC and MCL1 in the Genesis and Outcome of Non-Small-Cell Lung Cancer. Cancer Res 71(6):2212-21. PubMed: 21406400MGI: J:169920
- Antony N; Weir JR; McDougall AR; Mantamadiotis T; Meikle PJ; Cole TJ; Bird AD. 2013. cAMP response element binding protein1 is essential for activation of steroyl co-enzyme a desaturase 1 (Scd1) in mouse lung type II epithelial cells. PLoS One 8(4):e59763. PubMed: 23637738MGI: J:200565
- Balli D; Ustiyan V; Zhang Y; Wang IC; Masino AJ; Ren X; Whitsett JA; Kalinichenko VV; Kalin TV. 2013. Foxm1 transcription factor is required for lung fibrosis and epithelial-to-mesenchymal transition. EMBO J 32(2):231-44. PubMed: 23288041MGI: J:193263
- Basseres DS; Levantini E; Ji H; Monti S; Elf S; Dayaram T; Fenyus M; Kocher O; Golub T; Wong KK; Halmos B; Tenen DG. 2006. Respiratory failure due to differentiation arrest and expansion of alveolar cells following lung-specific loss of the transcription factor C/EBPalpha in mice. Mol Cell Biol 26(3):1109-23. PubMed: 16428462MGI: J:105593
- Bird AD; Choo YL; Hooper SB; McDougall AR; Cole TJ. 2014. Mesenchymal glucocorticoid receptor regulates the development of multiple cell layers of the mouse lung. Am J Respir Cell Mol Biol 50(2):419-28. PubMed: 24053134MGI: J:231865
- Bridges JP; Lin S; Ikegami M; Shannon JM. 2012. Conditional hypoxia inducible factor-1alpha induction in embryonic pulmonary epithelium impairs maturation and augments lymphangiogenesis. Dev Biol 362(1):24-41. PubMed: 22094019MGI: J:180152
- Bridges JP; Schehr A; Wang Y; Huo L; Besnard V; Ikegami M; Whitsett JA; Xu Y. 2014. Epithelial SCAP/INSIG/SREBP signaling regulates multiple biological processes during perinatal lung maturation. PLoS One 9(5):e91376. PubMed: 24806461MGI: J:216084
- Calvi C; Podowski M; Lopez-Mercado A; Metzger S; Misono K; Malinina A; Dikeman D; Poonyagariyon H; Ynalvez L; Derakhshandeh R; Le A; Merchant M; Schwall R; Neptune ER. 2013. Hepatocyte growth factor, a determinant of airspace homeostasis in the murine lung. PLoS Genet 9(2):e1003228. PubMed: 23459311MGI: J:195194
- Ceteci F; Ceteci S; Karreman C; Kramer BW; Asan E; Gotz R; Rapp UR. 2007. Disruption of Tumor Cell Adhesion Promotes Angiogenic Switch and Progression to Micrometastasis in RAF-Driven Murine Lung Cancer. Cancer Cell 12(2):145-159. PubMed: 17692806MGI: J:124321
- Chapman HA; Li X; Alexander JP; Brumwell A; Lorizio W; Tan K; Sonnenberg A; Wei Y; Vu TH. 2011. Integrin alpha6beta4 identifies an adult distal lung epithelial population with regenerative potential in mice. J Clin Invest 121(7):2855-62. PubMed: 21701069MGI: J:175915
- Chen G; Wan H; Luo F; Zhang L; Xu Y; Lewkowich I; Wills-Karp M; Whitsett JA. 2010. Foxa2 programs Th2 cell-mediated innate immunity in the developing lung. J Immunol 184(11):6133-41. PubMed: 20483781MGI: J:161217
- Chen H; Zhuang F; Liu YH; Xu B; Del Moral P; Deng W; Chai Y; Kolb M; Gauldie J; Warburton D; Moses HL; Shi W. 2008. TGF-beta receptor II in epithelia versus mesenchyme plays distinct roles in the developing lung. Eur Respir J 32(2):285-95. PubMed: 18321928MGI: J:137996
- Chen L; Acciani T; Le Cras T; Lutzko C; Perl AK. 2012. Dynamic regulation of platelet-derived growth factor receptor alpha expression in alveolar fibroblasts during realveolarization. Am J Respir Cell Mol Biol 47(4):517-27. PubMed: 22652199MGI: J:201241
- Chignalia AZ; Vogel SM; Reynolds AB; Mehta D; Dull RO; Minshall RD; Malik AB; Liu Y. 2015. p120-Catenin Expressed in Alveolar Type II Cells Is Essential for the Regulation of Lung Innate Immune Response. Am J Pathol 185(5):1251-63. PubMed: 25773174MGI: J:220680
- Clark JC; Tichelaar JW; Wert SE; Itoh N; Perl AK; Stahlman MT; Whitsett JA. 2001. FGF-10 disrupts lung morphogenesis and causes pulmonary adenomas in vivo. Am J Physiol Lung Cell Mol Physiol 280(4):L705-15. PubMed: 11238011MGI: J:68525
- Dave V; Childs T; Xu Y; Ikegami M; Besnard V; Maeda Y; Wert SE; Neilson JR; Crabtree GR; Whitsett JA. 2006. Calcineurin/Nfat signaling is required for perinatal lung maturation and function. J Clin Invest 116(10):2597-609. PubMed: 16998587MGI: J:114501
- Dave V; Wert SE; Tanner T; Thitoff AR; Loudy DE; Whitsett JA. 2008. Conditional deletion of Pten causes bronchiolar hyperplasia. Am J Respir Cell Mol Biol 38(3):337-45. PubMed: 17921358MGI: J:146355
- Ding BS; Nolan DJ; Guo P; Babazadeh AO; Cao Z; Rosenwaks Z; Crystal RG; Simons M; Sato TN; Worgall S; Shido K; Rabbany SY; Rafii S. 2011. Endothelial-derived angiocrine signals induce and sustain regenerative lung alveolarization. Cell 147(3):539-53. PubMed: 22036563MGI: J:178690
- Eckle T; Brodsky K; Bonney M; Packard T; Han J; Borchers CH; Mariani TJ; Kominsky DJ; Mittelbronn M; Eltzschig HK. 2013. HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium. PLoS Biol 11(9):e1001665. PubMed: 24086109MGI: J:201805
- Eckle T; Kewley EM; Brodsky KS; Tak E; Bonney S; Gobel M; Anderson D; Glover LE; Riegel AK; Colgan SP; Eltzschig HK. 2014. Identification of hypoxia-inducible factor HIF-1A as transcriptional regulator of the A2B adenosine receptor during acute lung injury. J Immunol 192(3):1249-56. PubMed: 24391213MGI: J:207297
- El-Hashash AH; Al Alam D; Turcatel G; Bellusci S; Warburton D. 2011. Eyes absent 1 (Eya1) is a critical coordinator of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung. Dev Biol 350(1):112-26. PubMed: 21129374MGI: J:170236
- El-Hashash AH; Turcatel G; Al Alam D; Buckley S; Tokumitsu H; Bellusci S; Warburton D. 2011. Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epithelium. Development 138(7):1395-407. PubMed: 21385765MGI: J:171504
- El-Hashash AH; Turcatel G; Varma S; Berika M; Al Alam D; Warburton D. 2012. Eya1 protein phosphatase regulates tight junction formation in lung distal epithelium. J Cell Sci 125(Pt 17):4036-48. PubMed: 22685326MGI: J:198889
- Fang P; Zhou L; Zhou Y; Kolls JK; Zheng T; Zhu Z. 2014. Immune modulatory effects of IL-22 on allergen-induced pulmonary inflammation. PLoS One 9(9):e107454. PubMed: 25254361MGI: J:222502
- Floyd HS; Farnsworth CL; Kock ND; Mizesko MC; Little JL; Dance ST; Everitt J; Tichelaar J; Whitsett JA; Miller MS. 2005. Conditional expression of the mutant Ki-rasG12C allele results in formation of benign lung adenomas: development of a novel mouse lung tumor model. Carcinogenesis 26(12):2196-206. PubMed: 16051643MGI: J:102839
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- Gontan C; de Munck A; Vermeij M; Grosveld F; Tibboel D; Rottier R. 2008. Sox2 is important for two crucial processes in lung development: branching morphogenesis and epithelial cell differentiation. Dev Biol 317(1):296-309. PubMed: 18374910MGI: J:136180
- Greenwood KK; Proper SP; Saini Y; Bramble LA; Jackson-Humbles DN; Wagner JG; Harkema JR; LaPres JJ. 2012. Neonatal epithelial hypoxia inducible factor-1alpha expression regulates the response of the lung to experimental asthma. Am J Physiol Lung Cell Mol Physiol 302(5):L455-62. PubMed: 22180657MGI: J:183445
- Gupte VV; Ramasamy SK; Reddy R; Lee J; Weinreb PH; Violette SM; Guenther A; Warburton D; Driscoll B; Minoo P; Bellusci S. 2009. Overexpression of fibroblast growth factor-10 during both inflammatory and fibrotic phases attenuates bleomycin-induced pulmonary fibrosis in mice. Am J Respir Crit Care Med 180(5):424-36. PubMed: 19498056MGI: J:167964
- Hahn DR; Na CL; Weaver TE. 2014. Reserve autophagic capacity in alveolar epithelia provides a replicative niche for influenza A virus. Am J Respir Cell Mol Biol 51(3):400-12. PubMed: 24661119MGI: J:232239
- Han CZ; Juncadella IJ; Kinchen JM; Buckley MW; Klibanov AL; Dryden K; Onengut-Gumuscu S; Erdbrugger U; Turner SD; Shim YM; Tung KS; Ravichandran KS. 2016. Macrophages redirect phagocytosis by non-professional phagocytes and influence inflammation. Nature 539(7630):570-574. PubMed: 27820945MGI: J:241315
- Hokuto I; Ikegami M; Yoshida M; Takeda K; Akira S; Perl AK; Hull WM; Wert SE; Whitsett JA. 2004. Stat-3 is required for pulmonary homeostasis during hyperoxia. J Clin Invest 113(1):28-37. PubMed: 14702106MGI: J:87622
- Hoshino T; Kato S; Oka N; Imaoka H; Kinoshita T; Takei S; Kitasato Y; Kawayama T; Imaizumi T; Yamada K; Young HA; Aizawa H. 2007. Pulmonary inflammation and emphysema: role of the cytokines IL-18 and IL-13. Am J Respir Crit Care Med 176(1):49-62. PubMed: 17400729MGI: J:147547
- Huang Y; Kempen MB; Munck AB; Swagemakers S; Driegen S; Mahavadi P; Meijer D; van Ijcken W; van der Spek P; Grosveld F; Gunther A; Tibboel D; Rottier RJ. 2012. Hypoxia-inducible factor 2alpha plays a critical role in the formation of alveoli and surfactant. Am J Respir Cell Mol Biol 46(2):224-32. PubMed: 22298531MGI: J:191907
- Ihara S; Kida H; Arase H; Tripathi LP; Chen YA; Kimura T; Yoshida M; Kashiwa Y; Hirata H; Fukamizu R; Inoue R; Hasegawa K; Goya S; Takahashi R; Minami T; Tsujino K; Suzuki M; Kohmo S; Inoue K; Nagatomo I; Takeda Y; Kijima T; Mizuguchi K; Tachibana I; Kumanogoh A. 2012. Inhibitory roles of signal transducer and activator of transcription 3 in antitumor immunity during carcinogen-induced lung tumorigenesis. Cancer Res 72(12):2990-9. PubMed: 22659452MGI: J:189293
- Ikeda H; Shiojima I; Oka T; Yoshida M; Maemura K; Walsh K; Igarashi T; Komuro I. 2011. Increased Akt-mTOR Signaling in Lung Epithelium Is Associated with Respiratory Distress Syndrome in Mice. Mol Cell Biol 31(5):1054-65. PubMed: 21189286MGI: J:169183
- Ikegami M; Falcone A; Whitsett JA. 2008. STAT-3 regulates surfactant phospholipid homeostasis in normal lung and during endotoxin-mediated lung injury. J Appl Physiol 104(6):1753-60. PubMed: 18369093MGI: J:183960
- Inoshima I; Inoshima N; Wilke GA; Powers ME; Frank KM; Wang Y; Bubeck Wardenburg J. 2011. A Staphylococcus aureus pore-forming toxin subverts the activity of ADAM10 to cause lethal infection in mice. Nat Med 17(10):1310-4. PubMed: 21926978MGI: J:177286
- Jia WJ; Jiang S; Tang QL; Shen D; Xue B; Ning W; Li CJ. 2016. Geranylgeranyl Diphosphate Synthase Modulates Fetal Lung Branching Morphogenesis Possibly through Controlling K-Ras Prenylation. Am J Pathol 186(6):1454-65. PubMed: 27106761MGI: J:233686
- Kalin TV; Wang IC; Meliton L; Zhang Y; Wert SE; Ren X; Snyder J; Bell SM; Graf L Jr; Whitsett JA; Kalinichenko VV. 2008. Forkhead Box m1 transcription factor is required for perinatal lung function. Proc Natl Acad Sci U S A 105(49):19330-5. PubMed: 19033457MGI: J:142246
- Kapere Ochieng J; Schilders K; Kool H; Buscop-van Kempen M; Boerema-De Munck A; Grosveld F; Wijnen R; Tibboel D; Rottier RJ. 2014. Differentiated type II pneumocytes can be reprogrammed by ectopic Sox2 expression. PLoS One 9(9):e107248. PubMed: 25210856MGI: J:222520
- Kida H; Mucenski ML; Thitoff AR; Le Cras TD; Park KS; Ikegami M; Muller W; Whitsett JA. 2008. GP130-STAT3 regulates epithelial cell migration and is required for repair of the bronchiolar epithelium. Am J Pathol 172(6):1542-54. PubMed: 18467707MGI: J:136187
- Kim KK; Wei Y; Szekeres C; Kugler MC; Wolters PJ; Hill ML; Frank JA; Brumwell AN; Wheeler SE; Kreidberg JA; Chapman HA. 2009. Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis. J Clin Invest 119(1):213-24. PubMed: 19104148MGI: J:144703
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- Kulkarni RM; Greenberg JM; Akeson AL. 2009. NFATc1 regulates lymphatic endothelial development. Mech Dev 126(5-6):350-65. PubMed: 19233265MGI: J:149253
- Kulkarni RM; Herman A; Ikegami M; Greenberg JM; Akeson AL. 2011. Lymphatic ontogeny and effect of hypoplasia in developing lung. Mech Dev 128(1-2):29-40. PubMed: 20932899MGI: J:170175
- Lawson WE; Cheng DS; Degryse AL; Tanjore H; Polosukhin VV; Xu XC; Newcomb DC; Jones BR; Roldan J; Lane KB; Morrisey EE; Beers MF; Yull FE; Blackwell TS. 2011. Endoplasmic reticulum stress enhances fibrotic remodeling in the lungs. Proc Natl Acad Sci U S A 108(26):10562-7. PubMed: 21670280MGI: J:173548
- Lin S; Ikegami M; Xu Y; Bosserhoff AK; Malkinson AM; Shannon JM. 2008. Misexpression of MIA disrupts lung morphogenesis and causes neonatal death. Dev Biol 316(2):441-55. PubMed: 18342301MGI: J:135990
- Liu Y; Sadikot RT; Adami GR; Kalinichenko VV; Pendyala S; Natarajan V; Zhao YY; Malik AB. 2011. FoxM1 mediates the progenitor function of type II epithelial cells in repairing alveolar injury induced by Pseudomonas aeruginosa. J Exp Med 208(7):1473-84. PubMed: 21708928MGI: J:176807
- Londhe VA; Tomi T; Nguyen TT; Lopez B; Smith JB. 2015. Overexpression of LINCR in the developing mouse lung epithelium inhibits distal differentiation and induces cystic changes. Dev Dyn 244(7):827-38. PubMed: 25904058MGI: J:223330
- Lu K; Reddy R; Berika M; Warburton D; El-Hashash AH. 2013. Abrogation of Eya1/Six1 disrupts the saccular phase of lung morphogenesis and causes remodeling. Dev Biol 382(1):110-23. PubMed: 23895934MGI: J:202226
- Luo Y; Chen H; Ren S; Li N; Mishina Y; Shi W. 2016. BMP signaling is essential in neonatal surfactant production during respiratory adaptation. Am J Physiol Lung Cell Mol Physiol 311(1):L29-38. PubMed: 27190064MGI: J:236055
- Mallory BP; Mead TJ; Wiginton DA; Kulkarni RM; Greenberg JM; Akeson AL. 2006. Lymphangiogenesis in the developing lung promoted by VEGF-A. Microvasc Res 72(1-2):62-73. PubMed: 16806288MGI: J:129289
- Martis PC; Whitsett JA; Xu Y; Perl AK; Wan H; Ikegami M. 2006. C/EBP{alpha} is required for lung maturation at birth. Development 133(6):1155-64. PubMed: 16467360MGI: J:106543
- Matsuzaki Y; Besnard V; Clark JC; Xu Y; Wert SE; Ikegami M; Whitsett JA. 2008. STAT3 regulates ABCA3 expression and influences lamellar body formation in alveolar type II cells. Am J Respir Cell Mol Biol 38(5):551-8. PubMed: 18096869MGI: J:149721
- Matsuzaki Y; Xu Y; Ikegami M; Besnard V; Park KS; Hull WM; Wert SE; Whitsett JA. 2006. Stat3 is required for cytoprotection of the respiratory epithelium during adenoviral infection. J Immunol 177(1):527-37. PubMed: 16785550MGI: J:134441
- Melino G. 2011. p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53. Cell Death Differ 18(9):1487-99. PubMed: 21760596MGI: J:203617
- Metzger DE; Stahlman MT; Shannon JM. 2008. Misexpression of ELF5 disrupts lung branching and inhibits epithelial differentiation. Dev Biol 320(1):149-60. PubMed: 18544451MGI: J:139210
- Miller LA; Wert SE; Clark JC; Xu Y; Perl AK; Whitsett JA. 2004. Role of Sonic hedgehog in patterning of tracheal-bronchial cartilage and the peripheral lung. Dev Dyn 231(1):57-71. PubMed: 15305287MGI: J:91723
- Minowada G; Miller YE. 2009. Overexpression of Sprouty 2 in mouse lung epithelium inhibits urethane-induced tumorigenesis. Am J Respir Cell Mol Biol 40(1):31-7. PubMed: 18635814MGI: J:155786
- Morimoto M; Kopan R. 2009. rtTA toxicity limits the usefulness of the SP-C-rtTA transgenic mouse. Dev Biol 325(1):171-8. PubMed: 19013447MGI: J:143537
- Morimoto M; Liu Z; Cheng HT; Winters N; Bader D; Kopan R. 2010. Canonical Notch signaling in the developing lung is required for determination of arterial smooth muscle cells and selection of Clara versus ciliated cell fate. J Cell Sci 123(Pt 2):213-24. PubMed: 20048339MGI: J:156690
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- Mucenski ML; Wert SE; Nation JM; Loudy DE; Huelsken J; Birchmeier W; Morrisey EE; Whitsett JA. 2003. beta-Catenin is required for specification of proximal/distal cell fate during lung morphogenesis. J Biol Chem 278(41):40231-8. PubMed: 12885771MGI: J:85946
- Nguyen NM; Kelley DG; Schlueter JA; Meyer MJ; Senior RM; Miner JH. 2005. Epithelial laminin alpha5 is necessary for distal epithelial cell maturation, VEGF production, and alveolization in the developing murine lung. Dev Biol 282(1):111-25. PubMed: 15936333MGI: J:104565
- Ochieng JK; Schilders K; Kool H; Boerema-De Munck A; Buscop-Van Kempen M; Gontan C; Smits R; Grosveld FG; Wijnen RM; Tibboel D; Rottier RJ. 2014. Sox2 regulates the emergence of lung basal cells by directly activating the transcription of Trp63. Am J Respir Cell Mol Biol 51(2):311-22. PubMed: 24669837MGI: J:232238
- Park KS; Wells JM; Zorn AM; Wert SE; Laubach VE; Fernandez LG; Whitsett JA. 2006. Transdifferentiation of ciliated cells during repair of the respiratory epithelium. Am J Respir Cell Mol Biol 34(2):151-7. PubMed: 16239640MGI: J:120191
- Park KS; Wells JM; Zorn AM; Wert SE; Whitsett JA. 2006. Sox17 influences the differentiation of respiratory epithelial cells. Dev Biol 294(1):192-202. PubMed: 16574095MGI: J:109303
- Perl AK; Gale E. 2009. FGF signaling is required for myofibroblast differentiation during alveolar regeneration. Am J Physiol Lung Cell Mol Physiol 297(2):L299-308. PubMed: 19502291MGI: J:151422
- Perl AK; Kist R; Shan Z; Scherer G; Whitsett JA. 2005. Normal lung development and function after Sox9 inactivation in the respiratory epithelium. Genesis 41(1):23-32. PubMed: 15645446MGI: J:95910
- Perl AK; Tichelaar JW; Whitsett JA. 2002. Conditional gene expression in the respiratory epithelium of the mouse. Transgenic Res 11(1):21-9. PubMed: 11874100MGI: J:129109
- Perl AK; Wert SE; Loudy DE; Shan Z; Blair PA; Whitsett JA. 2005. Conditional recombination reveals distinct subsets of epithelial cells in trachea, bronchi, and alveoli. Am J Respir Cell Mol Biol 33(5):455-62. PubMed: 16055670MGI: J:132772
- Perl AK; Wert SE; Nagy A; Lobe CG; Whitsett JA. 2002. Early restriction of peripheral and proximal cell lineages during formation of the lung. Proc Natl Acad Sci U S A 99(16):10482-7. PubMed: 12145322MGI: J:78365
- Perl AK; Zhang L; Whitsett JA. 2009. Conditional expression of genes in the respiratory epithelium in transgenic mice: cautionary notes and toward building a better mouse trap. Am J Respir Cell Mol Biol 40(1):1-3. PubMed: 19075182MGI: J:179352
- Planes C; Randrianarison NH; Charles RP; Frateschi S; Cluzeaud F; Vuagniaux G; Soler P; Clerici C; Rossier BC; Hummler E. 2010. ENaC-mediated alveolar fluid clearance and lung fluid balance depend on the channel-activating protease 1. EMBO Mol Med 2(1):26-37. PubMed: 20043279MGI: J:232314
- Plosa EJ; Young LR; Gulleman PM; Polosukhin VV; Zaynagetdinov R; Benjamin JT; Im AM; van der Meer R; Gleaves LA; Bulus N; Han W; Prince LS; Blackwell TS; Zent R. 2014. Epithelial beta1 integrin is required for lung branching morphogenesis and alveolarization. Development 141(24):4751-62. PubMed: 25395457MGI: J:217594
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