JAX
Mouse Strain Datasheet - 006232
B6.Cg-Tg(Scgb1a1-rtTA)1Jaw/J
These CCSP-rtTA transgenic mice express the reverse tetracycline-controlled transactivator (rtTA) protein under the control of the rat CCSP (or Scgb1a1, secretoglobin, family 1A, member 1 (uteroglobin)) gene promoter, and provide a "Tet-On" tool that allows the inducible expression of genes in the developing and adult lung and respiratory epithelium.
Donating Investigator
IMR Colony, The Jackson Laboratory
Genetic overview
| Genetic Background | Generation |
|---|---|
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Tg(Scgb1a1-rtTA)1Jaw
| Allele Type |
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| Transgenic (Transactivator) |
Research Applications
- Developmental Biology Research
- Immunology, Inflammation and Autoimmunity Research
- Internal/Organ Research
- Research Tools
Detailed Description
Mice hemizygous for the CCSP-rtTA transgene are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities. These transgenic mice express the reverse tetracycline-controlled transactivator (rtTA) protein under the control of the rat Scgb1a1, secretoglobin, family 1A, member 1 (uteroglobin), gene promoter. rtTA activity detected in bronchial and type II epithelial cells of lung tissue from adult transgenic mice and in embryos from pregnant females treated with the tetracycline analog doxycycline (dox). In the latter, rtTA-induced expression of a luciferase reporter under the regulation of a tetracycline-responsive promoter (TRE; tetO) has been detected as early as embryonic day 12.5. When hemizygotes are mated to a second transgenic strain carrying a gene of interest under the regulatory control of a TRE, expression of the target gene in the bitransgenic offspring can be regulated by dox; in the presence of dox, transcription of the target gene is induced in cells where rtTA is expressed. These CCSP-rtTA transgenic mice provide a "Tet-On" tool that allows the inducible expression of genes in the developing and adult lung and respiratory epithelium.
Of note, these CCSP-rtTA mice are available on different genetic backgrounds including FVB/N (Stock No. 006222), C57BL/6J (Stock No. 006232), and BALB/cJ (Stock No. 006242).
In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles frequently are moved to a genetic background different from that on which an allele was first characterized. This is the case for this strain. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.
Development
A transgenic construct containing 2.3kb sequence of the rat Scgb1a1, secretoglobin, family 1A, member 1 (uteroglobin), gene promoter, the reverse tetracycline regulatable transactivator protein (rtTA) gene, and 2.0kb sequence of the human growth hormone gene, containing introns and polyadenylation site, was injected into mixed C57BL/6 and 129 background embryos. Founder mice were bred to FVB/N animals. Upon arrival at The Jackson Laboratory, these mice were backcrossed to C57BL/6J mice for at least 5 generations.
Expression Data
| Expressed Gene | rtTA, reverse tetracycline-controlled transactivator, E. coli |
|---|---|
| Site of Expression | Expresses rtTA in developing and adult lung. |
Control Suggestions
Selected References
- Tichelaar JW; Lu W; Whitsett JA. 2000. Conditional expression of fibroblast growth factor-7 in the developing and mature lung. J Biol Chem 275(16):11858-64. PubMed: 10766812MGI: J:61736
Tg(Scgb1a1-rtTA)1Jaw
Allele Symbol: Tg(Scgb1a1-rtTA)1Jaw
| Allele Name | transgene insertion 1, Jeffrey A Whitsett |
|---|---|
| Allele Type | Transgenic (Transactivator) |
| Allele Synonym(s) | CC10-rtTA; CCSP-rtTA; CCSPtg; Scgb1a1-rtTA; Tg(Ugb-rtTA)1Jaw |
| Gene Symbol and Name | Tg(Scgb1a1-rtTA)1Jaw, transgene insertion 1, Jeffrey A Whitsett |
| Gene Synonym(s) | CC10-rtTA; CCSP-rtTA; CCSPtg; Tg(Ugb-rtTA)1Jaw |
| Promoter | Scgb1a1, secretoglobin family 1A member 1, rat |
| Expressed Gene | rtTA, reverse tetracycline-controlled transactivator, E. coli |
| Site of Expression | Expresses rtTA in developing and adult lung. |
| Strain of Origin | 129 and C57BL/6 |
| Chromosome | UN |
| General Note | Phenotypic Similarity to Human Syndrome: Bronchopulmonary dysplasia (J:130523, J:171488). |
| Molecular Note | The transgene is composed of 2.3 kb of rat Ugb (Scgb1a1) promoter, a reverse tetracycline responsive transactivator gene (rt-TA), and 2 kb of human growth hormone sequences, which includes introns and a polyadenylation signal. Transgene expression was confirmed by RT-PCR analysis. The rat Scgb1a1 promoter is active in respiratory epithelial cells. |
| Mutations Made By | Dr. Jeffrey Whitsett, Children's Hospital Medical Center |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Developmental Biology Research
- Internal/Organ Defects
- lung
- Internal/Organ Defects
- Immunology, Inflammation and Autoimmunity Research
- Cystic Fibrosis
- Internal/Organ Research
- Lung Defects
- Research Tools
- Cancer Research
- Tetop Tet System
- Developmental Biology Research
- Genetics Research
- Mutagenesis and Transgenesis
- Mutagenesis and Transgenesis: Tetop Tet System
- Immunology, Inflammation and Autoimmunity Research
- Internal/Organ Research
- Tet Expression Systems
- tTA/rtTA Expressing Strains
- Cancer Research
References
- Tichelaar JW; Lu W; Whitsett JA. 2000. Conditional expression of fibroblast growth factor-7 in the developing and mature lung. J Biol Chem 275(16):11858-64. PubMed: 10766812MGI: J:61736
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- Baluk P; Hogmalm A; Bry M; Alitalo K; Bry K; McDonald DM. 2013. Transgenic overexpression of interleukin-1beta induces persistent lymphangiogenesis but not angiogenesis in mouse airways. Am J Pathol 182(4):1434-47. PubMed: 23391392MGI: J:195210
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- Kramer EL; Deutsch GH; Sartor MA; Hardie WD; Ikegami M; Korfhagen TR; Le Cras TD. 2007. Perinatal increases in TGF-{alpha} disrupt the saccular phase of lung morphogenesis and cause remodeling: microarray analysis. Am J Physiol Lung Cell Mol Physiol 293(2):L314-27. PubMed: 17468132MGI: J:125842
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- Lange AW; Keiser AR; Wells JM; Zorn AM; Whitsett JA. 2009. Sox17 promotes cell cycle progression and inhibits TGF-beta/Smad3 signaling to initiate progenitor cell behavior in the respiratory epithelium. PLoS One 4(5):e5711. PubMed: 19479035MGI: J:148833
- Lappalainen U; Whitsett JA; Wert SE; Tichelaar JW; Bry K. 2005. Interleukin-1beta causes pulmonary inflammation, emphysema, and airway remodeling in the adult murine lung. Am J Respir Cell Mol Biol 32(4):311-8. PubMed: 15668323MGI: J:107601
- Lastwika KJ; Wilson W 3rd; Li QK; Norris J; Xu H; Ghazarian SR; Kitagawa H; Kawabata S; Taube JM; Yao S; Liu LN; Gills JJ; Dennis PA. 2016. Control of PD-L1 Expression by Oncogenic Activation of the AKT-mTOR Pathway in Non-Small Cell Lung Cancer. Cancer Res 76(2):227-38. PubMed: 26637667MGI: J:237661
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