This strain represents one of a panel of inter-species chromosome substitution (or consomic) strains (IC-ISS). Each strain carries a chromosome from the Mus musculus musculus wild-derived strain PWD/Ph introgressed into a Mus musculus domesticus C57BL/6J background. The two species are believed to have diverged 350,000 to one million years ago and exhibit multiple genetic and phenotypic differences. The strain set also includes a conplastic strain (mtPWD/Ph) created by sequential backcrossing of the donor female to the host male. A conplastic strain carries the mitochondrial genome of the donor strain. The IC-ISS strains represent a tool for dissection of quantitative trait loci.


A recently performed SNP analysis using a higher-resolution panel (GigaMuga) indicates that The Jackson Laboratory colony for Stock 006226 contains significant contributions from the C57BL/6 genome, rendering the strain sub-consomic. The entirety of Chromosome 4 (Chr 4) should be of PWD/Ph origin. 


The proximal end of Chr 4 is of C57BL/6 origin (break-point is between markers 04-017015246-M; rs3709725 [C57BL/6] and 04-019063943-M; rs3708738 [PWD]). The distal portion of Chr 4 is also of C57BL/6 origin (break-point is between markers 04-120122875-M; rs3702270 [PWD] and 04-122948823-M; rs3673616 [C57BL/6]) with the genetic contribution solely C57BL/6 through the end of the chromosome.


It is thought that the event introducing the C57BL/6 contribution occurred in 2010.

Chromosome 4 (Chr 4) from PWD/Ph replaces a significant portion, but not all, of the homologous C57BL/6J Chr 4 in this sub-consomic strain.&nbsp;

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