CD7/JlsJ

Stock number: 006178
Research areas: Research Tools

Description

This one of four strains derived from CD-1 mice to study the possible role of relative estrogen responsiveness in experimental Candida vaginitis infection. This strain, as well the others, is less responsive to estradiol than C57BL/6 mice.

Detailed description

Swiss derived CD-1 mice are less responsive to exogenous estradiol than most inbred strains as measured by resistance to decreases in testes weight, spermatogenesis, and spermatid development. Derived from CD-1, the inbred strains CD3/JlsJ, CD7/JlsJ, and CD9/JlsJ mice exhibit a moderate sensitivity to endocrine disruption by estradiol, while CD10/JlsJ mice are highly resistant to endocrine disruption by estradiol (personal communication). All lines generated in the selection program are significantly less responsive to estradiol than C57BL/6 mice.

The selectively bred strains CD3/JlsJ (Stock No. 006177), CD7/JlsJ (Stock No. 006178), CD9/JlsJ (Stock No. 006179) and CD10/JlsJ (Stock No. 006180) may serve as tools for mapping and characterizing genes responsible for estradiol sensitivity.

SNP data is available for this strain on the Wellcome Trust Centre for Human Genetics site.

Development

This inbred strain was generated at the University of California-Davis as part of a selection program for hyposensitivity or hypersensitivity to exogenous 17-beta-estradiol (E2). All lines were derived from CD-1 mice. This strain reached the 41st generation of inbreeding in 2006. The Jackson Laboratory Repository imported four of these strains in 2006.