This one of four strains derived from CD-1 mice to study the possible role of relative estrogen responsiveness in experimental Candida vaginitis infection. This strain, as well the others, is less responsive to estradiol than C57BL/6 mice.
Dr. Jimmy Spearow, University of California - Davis
Swiss derived CD-1 mice are less responsive to exogenous estradiol than most inbred strains as measured by resistance to decreases in testes weight, spermatogenesis, and spermatid development. Derived from CD-1, the inbred strains CD3/JlsJ, CD7/JlsJ, and CD9/JlsJ mice exhibit a moderate sensitivity to endocrine disruption by estradiol, while CD10/JlsJ mice are highly resistant to endocrine disruption by estradiol (personal communication). All lines generated in the selection program are significantly less responsive to estradiol than C57BL/6 mice.
The selectively bred strains CD3/JlsJ (Stock No. 006177), CD7/JlsJ (Stock No. 006178), CD9/JlsJ (Stock No. 006179) and CD10/JlsJ (Stock No. 006180) may serve as tools for mapping and characterizing genes responsible for estradiol sensitivity.
SNP data is available for this strain on the Wellcome Trust Centre for Human Genetics site.
This inbred strain was generated at the University of California-Davis as part of a selection program for hyposensitivity or hypersensitivity to exogenous 17-beta-estradiol (E2). All lines were derived from CD-1 mice. This strain reached the 41st generation of inbreeding in 2006. The Jackson Laboratory Repository imported four of these strains in 2006.
Currently there are no related genes or alleles for this strain.
When using the CD7/JlsJ mouse strain in a publication, please include JAX stock #006178 in your Materials and Methods section.
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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