The mutation black and white (baw) causes a light coat color on the ventrum of affected mice. The pattern is like that seen on mice carrying the black and tan mutation (at), but the hair is white on baw homozygotes rather than tan. In addition, the remaining coat is flecked with white hairs, particularly obvious as the mice age.
The black and white (baw) mutation arose spontaneously on the C57BL/10ScSnJ background at The Jackson Laboratory in approximately 1983. It was backcrossed twice to C57BL/10ScSnJ and then maintained by sibling mating. In 2005 embryos were generated for cryopreservation by in vitro fertilization from C57BL/6J females and homozygous males at generation N2F48.
|Allele Name||black and white|
|Gene Symbol and Name||baw, black and white|
|Strain of Origin||C57BL/10SnJ|
|General Note||It was expected that this phenotype would be the result of a remutation to the nonagouti gene on Chr 2; however, the chromosomal location on Chr 18 for this new mutant ruled out allelism.|
|Molecular Note||This allele is a spontaneous mutation that arose at The Jackson Laboratory.|
When using the black and white mouse strain in a publication, please cite the originating article(s) and include JAX stock #006157 in your Materials and Methods section.