B6;B10SnJ-baw/J

Stock number: 006157
Product name: black and white
Research areas: Dermatology Research

Description

These mice harbor a spontaneous mutation on Chromosome 18 that causes a light coat color on the ventrum of affected mice.

Detailed description

The mutation black and white (baw) causes a light coat color on the ventrum of affected mice. The pattern is like that seen on mice carrying the black and tan mutation (a^t), but the hair is white on baw homozygotes rather than tan. In addition, the remaining coat is flecked with white hairs, particularly obvious as the mice age.

Development

The black and white (baw) mutation arose spontaneously on the C57BL/10ScSnJ background at The Jackson Laboratory in approximately 1983. It was backcrossed twice to C57BL/10ScSnJ and then maintained by sibling mating. In 2005 embryos were generated for cryopreservation by in vitro fertilization from C57BL/6J females and homozygous males at generation N2F48.

Allele

Symbol: baw
Name: black and white
MGI accession ID: MGI:3042545
Generation method: Spontaneous
Marker symbol: baw
Marker name: black and white
Chromosome: 18
Strain of origin: C57BL/10SnJ
Molecular note: This allele is a spontaneous mutation that arose at The Jackson Laboratory.
General note: It was expected that this phenotype would be the result of a remutation to the nonagouti gene on Chr 2; however, the chromosomal location on Chr 18 for this new mutant ruled out allelism.