The inbred strain, GR, carries the Mtv2a allele. This allele controls expression of endogenous MMTV and the early development of hormone-induced mammary tumors. Nearly all breeding females develop mammary tumors prior to one year of age. GR is used to study endocrine regulation of mammary gland development and tumorigenesis.Read More +
The inbred strain, GR carries the Mtv2a allele. This allele controls expression of endogenous MMTV and the early development of hormone-induced mammary tumors. Nearly all breeding females develop mammary tumors prior to one year of age (van Nie et al. 1977). Most females will exhibit small tumors by the day of first parturition (van Nie et al. 1971). These tumors are most often of the Dunn classification type B adenocarcinoma. MMTV is transmitted through both the milk and the germinal cells of both males and females. Foster nursing does not eliminate endogenous mammary tumor virus (Muhlbock 1965). MTV-antigens are detectable by immunodiffusion assay in the milk of the first lactation period. (van Nie et al. 1977). GR is used extensively to study endocrine regulation of mammary gland development and tumorigenesis.
The GR strain was introduced to the Netherlands Cancer Institute in 1955 by professor Otto Muhlbock. He received breeding pairs from professor Grumbach, who had used these mice under the name 'Gunder strain' in his tuberculosis studies at the Institut fur Medizinische Mikrobologie der Universitat Zurich (Muhlbock O, 1965). The colony at the Netherlands Cancer Institute reached F68 in 1976. The history of this particular colony can be traced to 1986 where it was maintained at Albert Ochsner Medical Foundation in New Orleans, Louisiana. Sagres Discovery imported the colony from Dr. Om Prakash at Albert Ochsner in 2001 and maintained it as a private colony at The Jackson Laboratory. It was donated to The Jackson Laboratory Repository in 2006.
|Allele Name||mammary tumor virus locus 2, present|
|Allele Type||Not Applicable|
|Gene Symbol and Name||Mtv2, mammary tumor virus locus 2|
|Strain of Origin||Not Applicable|
|General Note||The provirus is present in the following strains: GR/Imr, GR, and SHN/Mei.|