Mice homozygous for the Snell's waltzer 2 Jackson mutation display circling and head tossing behavior and are deaf. They are unable to orient in water to swim.
The Snell's waltzer 2 Jackson mutation arose spontaneously in the strain NOD.CB17-Prkdcscid/J (stock #001303) at The Jackson Laboratory in December, 1999. Homozygous males were bred to NOD.NON-H2nb1/LtJ and the offspring intercrossed. Mice lacking the Prkdcscid mutation were selected to continue the line. The Myo6sv-2J mutation was then transferred to the C57BL/6J background by backcross-intercross breeding, reaching NE8 in 2006 and then being maintained by sibling breeding heterozygous females with homozygous sibling males until another backcross to C57BL/6J in 2010.
When using the Snell's waltzer 2 Jackson mouse strain in a publication, please cite the originating article(s) and include JAX stock #006124 in your Materials and Methods section.