Homozygous mice carrying this spontaneous mutation exhibit a progressive S-shaped kyphosis of the lumbar region resulting in a shortened trunk.
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous | sky | severe kyphosis |
Mice homozygous for the severe kyphosis mutation have open eyelids at birth leading to injury and blindness, a progressive S-shaped kyphosis of the lumbar region of the spine, and a resultant shortened trunk and higher tail position. Small granulomas in muscle and brown fat are also found. Death usually occurs between 3 and 6 months of age and homozygotes do not breed.
The severe kyphosis mutation (sky) arose spontaneously in 1988 at The Jackson Laboratory in the DBA/2J inbred strain when that inbred was at generation F160. It was maintained on this background by sibling breeding for 40 generations then backcrossed twice to DBA/2J before again being maintained by sibling breeding. This strain reached generation F160+40N2F12 in 2008.
When using the severe kyphosis mouse strain in a publication, please cite the originating article(s) and include JAX stock #006057 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Heterozygous for sky |
Frozen Mouse Embryo | DBA/2J-sky/J | $2595.00 |
Frozen Mouse Embryo | DBA/2J-sky/J | $2595.00 |
Frozen Mouse Embryo | DBA/2J-sky/J | $3373.50 |
Frozen Mouse Embryo | DBA/2J-sky/J | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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