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B6;D1Lac-Scd1ab-2J/J
Stock No: 005956 | asebia 2 Jackson
  • Spontaneous Mutation
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Overview

Also Known As:asebia 2 Jackson

Mice homozygous for the Scd1ab-2J allele show slightly hunched posture, dry, scaly skin, thin fur, and small eyes with encrusted eyelids stuck shut. They have hypoplasia of the sebaceous glands and other hair follicle abnormalities that result in scarring alopecia. They also have a paucity of adipose tissue, thin subcutis, and a distinctive odor.

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Genetic overview

Genetic Background Generation
F?+17
(2016-12-29 00:00:00)

Scd1ab-2J

Allele Type Gene Symbol Gene Name
Spontaneous Scd1 stearoyl-Coenzyme A desaturase 1
View Genetics

Research Applications

  • Cardiovascular Research
  • Dermatology Research
  • Internal/Organ Research
  • Metabolism Research
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Base Price

Starting at:

$205.90 Domestic price for female
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Details

Detailed Description

The overall appearance of mice homozygous for either the Scd1ab-2J or the Scd1ab-J (no longer available) allele includes slightly hunched posture, dry, scaly skin, thin fur sometimes detectable by 7 days of age, and small eyes with encrusted eyelids stuck shut. They have hypoplasia of the sebaceous glands and other hair follicle abnormalities that result in scarring alopecia. These mice have a paucity of adipose tissue, thin subcutis, and a distinctive odor. Hepatic cholesterol ester and triglyceride synthesis was shown to be deficient in Scd1ab-J homozygotes and could not be restored through diet. Early studies of skin lipids in the original asebia mutant ((Scd1ab) revealed a deficiency in wax esters, wax diesters, and sterols esterified with very long-chain fatty acids along with an increase in free sterols. (Wilkinson and Darasek, 1966; Sundberg et al., 1994; Zheng et al. 1999; Miyazaki et al., 2000; Sundberg et al., 2000)

Mice homozygous for the Scd1ab-2J allele showed greater dermal inflammatory infiltrate in the skin and thicker epidermis than did Scd1ab-J mice. Scd1ab-2J homozygotes show an increased transepidermal water loss and corresponding ad libitum intake of water that was not seen in Scd1ab-J homozygotes. For a thorough description see Sundberg et al., 2000 and Sundberg, 1994.

Control Suggestions

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Additional Information

  • Considerations for Choosing Controls

Genetics

Scd1ab-2J

Allele Symbol: Scd1ab-2J

Allele Name asebia 2 Jackson
Allele Type Spontaneous
Allele Synonym(s)
Gene Symbol and Name Scd1, stearoyl-Coenzyme A desaturase 1
Gene Synonym(s)
Strain of Origin DBA/1LacJ
Chromosome 19
Molecular Note An 18 bp deletion in the exon 2/intron 2 boundary.

Disease/Phenotype

Disease Terms

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Genotype: Scd1ab-2J related

  • Cardiovascular Research
    • Hypotriglyceridemia
  • Dermatology Research
    • Skin and Hair Texture Defects
  • Internal/Organ Research
    • Adipose Defects
  • Metabolism Research
    • Lipid Metabolism

Mammalian Phenotype Terms by Genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain

Genotype: Scd1ab-2J/Scd1ab-2J
DBA/1LacJ-Scd1/J

behavior/neurological phenotype

  • hunched posture
      (MGI Ref ID J:62699)
  • increased fluid intake
      (MGI Ref ID J:62699)

homeostasis/metabolism phenotype

  • abnormal lipid level
    • mice exhibit a reduction in skin surface lipids such as sterol esters and cholesterol with a total loss of diol esters unlike in wild-type mice
    • (MGI Ref ID J:62699)
  • impaired skin barrier function
    • transepidermal water loss is increased 4.5-fold compared to in wild-type mice
    • (MGI Ref ID J:62699)

immune system phenotype

  • granulomatous inflammation
    • hair shafts rupture through the base of the hair follicle and induce a foreign body granuloma in the dermal stroma resulting in dermal scarring and eventually scarring of the hair follicle
    • (MGI Ref ID J:62699)

integument phenotype

  • abnormal skin morphology
    • mice exhibit thicker than normal epidermis, Malphigian layer and stratum corneum
    • (MGI Ref ID J:62699)
  • flaky skin
    • moderate white flaking is observed when hair is removed unlike in wild-type mice
    • (MGI Ref ID J:62699)
  • impaired skin barrier function
    • transepidermal water loss is increased 4.5-fold compared to in wild-type mice
    • (MGI Ref ID J:62699)
  • thick dermal layer
      (MGI Ref ID J:62699)
  • small sebaceous gland
    • mice have small Meibomian, perianal and cerimous glands
    • (MGI Ref ID J:62699)
    • at day 6 mice have very small sebaceous glands compared to in wild-type mice
    • (MGI Ref ID J:62699)
    • Normal - however, preputial, clitoral, lingual, Harderian and lacrimal glands are normal
    • (MGI Ref ID J:62699)
  • abnormal hair cycle
    • while few follicles continue to cycle, with each cycle there is a progressive loss of individual follicles
    • (MGI Ref ID J:62699)
    • follicles stay in anagen longer than in wild-type mice
    • (MGI Ref ID J:62699)
  • abnormal hair follicle bulb morphology
    • hair follicle bulbar histology is distorted compared to in wild-type mice
    • (MGI Ref ID J:62699)
  • abnormal sebocyte morphology
    • although some early sebaceous differentiation occurs, sebocytes appear small and their cytoplasm is brightly eosinophilic, unlike wild-type cells
    • (MGI Ref ID J:62699)
  • enlarged hair follicles
    • during the first anagen stage the hair follicles are unusually long and extend at a sharp angle into the deep subcutis unlike in wild-type mice
    • (MGI Ref ID J:62699)
  • parakeratosis
    • in focal areas
    • (MGI Ref ID J:62699)
  • scaly skin
      (MGI Ref ID J:62699)
  • abnormal hair follicle morphology
    • hair shafts rupture through the base of the hair follicle and induce a foreign body granuloma in the dermal stroma resulting in dermal scarring and eventually scarring of the hair follicle
    • (MGI Ref ID J:62699)
  • small perianal sebaceous gland
      (MGI Ref ID J:62699)
  • acanthosis
      (MGI Ref ID J:62699)
  • dry skin
      (MGI Ref ID J:62699)
  • thick epidermis
      (MGI Ref ID J:62699)
  • abnormal hair shaft morphology
    • hair shafts rupture through the base of the hair follicle and induce a foreign body granuloma in the dermal stroma resulting in dermal scarring and eventually scarring of the hair follicle
    • (MGI Ref ID J:62699)
  • matted coat
      (MGI Ref ID J:62699)
  • orthokeratosis
    • mice exhibit varying degrees of orthokeratotic hyperkeratosis
    • (MGI Ref ID J:62699)
  • sebaceous gland hypoplasia
    • extreme sebaceous gland hypoplasia
    • (MGI Ref ID J:62699)
  • small Meibomian gland
    • small
    • (MGI Ref ID J:62699)
  • abnormal hair follicle inner root sheath morphology
    • the inner root sheath is retained beyond the midfollicle into the outer piliary canal unlike in wild-type mice
    • (MGI Ref ID J:62699)
  • sparse hair
      (MGI Ref ID J:62699)

endocrine/exocrine gland phenotype

  • abnormal sebocyte morphology
    • although some early sebaceous differentiation occurs, sebocytes appear small and their cytoplasm is brightly eosinophilic, unlike wild-type cells
    • (MGI Ref ID J:62699)
  • sebaceous gland hypoplasia
    • extreme sebaceous gland hypoplasia
    • (MGI Ref ID J:62699)
  • small Meibomian gland
    • small
    • (MGI Ref ID J:62699)
  • small sebaceous gland
    • mice have small Meibomian, perianal and cerimous glands
    • (MGI Ref ID J:62699)
    • at day 6 mice have very small sebaceous glands compared to in wild-type mice
    • (MGI Ref ID J:62699)
    • Normal - however, preputial, clitoral, lingual, Harderian and lacrimal glands are normal
    • (MGI Ref ID J:62699)
  • small perianal sebaceous gland
      (MGI Ref ID J:62699)

renal/urinary system phenotype

  • polyuria
    • urine output is increased by 2% compared to in wild-type mice
    • (MGI Ref ID J:62699)

vision/eye phenotype

  • small Meibomian gland
    • small
    • (MGI Ref ID J:62699)

References

Additional - Scd1ab-2J related

Technical Support

CONTACT TECHNICAL SUPPORT
  • Genotyping Protocols

    • Genotyping resources and troubleshooting
  • Breeding Considerations

    The homozygotes are very poor breeders and the mutation is best maintained using heterozygous females bred to homozygous males.

    • Additional Breeding and Husbandry Support
  • Citation

    When using the asebia 2 Jackson mouse strain in a publication, please cite the originating article(s) and include JAX stock #005956 in your Materials and Methods section.

Animal Health Reports

Facility Barrier Level Descriptions

MGL277 (Low)

Pricing & Availability

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.

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