Overview

Also Known As:asebia 2 Jackson

Mice homozygous for the Scd1^ab-2J allele show slightly hunched posture, dry, scaly skin, thin fur, and small eyes with encrusted eyelids stuck shut. They have hypoplasia of the sebaceous glands and other hair follicle abnormalities that result in scarring alopecia. They also have a paucity of adipose tissue, thin subcutis, and a distinctive odor.

Genetic overview

Genetic Background	Generation
	F?+17 (2016-12-29 00:00:00)

Scd1^ab-2J

Allele Type	Gene Symbol	Gene Name
Spontaneous	Scd1	stearoyl-Coenzyme A desaturase 1

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Research Applications

Cardiovascular Research
Dermatology Research
Internal/Organ Research
Metabolism Research

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Base Price

Starting at:

$205.90 Domestic price for female

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Details

Detailed Description

The overall appearance of mice homozygous for either the Scd1^ab-2J or the Scd1^ab-J (no longer available) allele includes slightly hunched posture, dry, scaly skin, thin fur sometimes detectable by 7 days of age, and small eyes with encrusted eyelids stuck shut. They have hypoplasia of the sebaceous glands and other hair follicle abnormalities that result in scarring alopecia. These mice have a paucity of adipose tissue, thin subcutis, and a distinctive odor. Hepatic cholesterol ester and triglyceride synthesis was shown to be deficient in Scd1^ab-J homozygotes and could not be restored through diet. Early studies of skin lipids in the original asebia mutant ((Scd1^ab) revealed a deficiency in wax esters, wax diesters, and sterols esterified with very long-chain fatty acids along with an increase in free sterols. (Wilkinson and Darasek, 1966; Sundberg et al., 1994; Zheng et al. 1999; Miyazaki et al., 2000; Sundberg et al., 2000)

Mice homozygous for the Scd1^ab-2J allele showed greater dermal inflammatory infiltrate in the skin and thicker epidermis than did Scd1^ab-J mice. Scd1^ab-2J homozygotes show an increased transepidermal water loss and corresponding ad libitum intake of water that was not seen in Scd1^ab-J homozygotes. For a thorough description see Sundberg et al., 2000 and Sundberg, 1994.

Control Suggestions

None Available

Additional Information

Considerations for Choosing Controls

Genetics

Scd1^ab-2J

Allele Symbol: Scd1^ab-2J

Allele Name	asebia 2 Jackson
Allele Type	Spontaneous
Allele Synonym(s)
Gene Symbol and Name	Scd1, stearoyl-Coenzyme A desaturase 1
Gene Synonym(s)
Strain of Origin	DBA/1LacJ
Chromosome	19
Molecular Note	An 18 bp deletion in the exon 2/intron 2 boundary.

Disease/Phenotype

Disease Terms

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Genotype: Scd1^ab-2J related

Cardiovascular Research
- Hypotriglyceridemia
Dermatology Research
- Skin and Hair Texture Defects
Internal/Organ Research
- Adipose Defects
Metabolism Research
- Lipid Metabolism

Mammalian Phenotype Terms by Genotype

The following phenotype information is associated with a similar, but not exact match to this JAX^® Mice strain

Genotype: Scd1^ab-2J/Scd1^ab-2J
DBA/1LacJ-Scd1/J

behavior/neurological phenotype

hunched posture

increased fluid intake

homeostasis/metabolism phenotype

abnormal lipid level
- mice exhibit a reduction in skin surface lipids such as sterol esters and cholesterol with a total loss of diol esters unlike in wild-type mice

impaired skin barrier function
- transepidermal water loss is increased 4.5-fold compared to in wild-type mice

immune system phenotype

granulomatous inflammation
- hair shafts rupture through the base of the hair follicle and induce a foreign body granuloma in the dermal stroma resulting in dermal scarring and eventually scarring of the hair follicle

integument phenotype

abnormal hair cycle
- follicles stay in anagen longer than in wild-type mice
- while few follicles continue to cycle, with each cycle there is a progressive loss of individual follicles

abnormal hair follicle bulb morphology
- hair follicle bulbar histology is distorted compared to in wild-type mice

abnormal hair follicle inner root sheath morphology
- the inner root sheath is retained beyond the midfollicle into the outer piliary canal unlike in wild-type mice

abnormal hair follicle morphology
- hair shafts rupture through the base of the hair follicle and induce a foreign body granuloma in the dermal stroma resulting in dermal scarring and eventually scarring of the hair follicle

abnormal hair shaft morphology
- hair shafts rupture through the base of the hair follicle and induce a foreign body granuloma in the dermal stroma resulting in dermal scarring and eventually scarring of the hair follicle

abnormal sebocyte morphology
- although some early sebaceous differentiation occurs, sebocytes appear small and their cytoplasm is brightly eosinophilic, unlike wild-type cells

abnormal skin morphology
- mice exhibit thicker than normal epidermis, Malphigian layer and stratum corneum

acanthosis

dry skin

enlarged hair follicles
- during the first anagen stage the hair follicles are unusually long and extend at a sharp angle into the deep subcutis unlike in wild-type mice

flaky skin
- moderate white flaking is observed when hair is removed unlike in wild-type mice

impaired skin barrier function
- transepidermal water loss is increased 4.5-fold compared to in wild-type mice

matted coat

orthokeratosis
- mice exhibit varying degrees of orthokeratotic hyperkeratosis

parakeratosis
- in focal areas

scaly skin

sebaceous gland hypoplasia
- extreme sebaceous gland hypoplasia

small Meibomian gland
- small

small perianal sebaceous gland

small sebaceous gland
- at day 6 mice have very small sebaceous glands compared to in wild-type mice
- Normal - however, preputial, clitoral, lingual, Harderian and lacrimal glands are normal
- mice have small Meibomian, perianal and cerimous glands

sparse hair

thick dermal layer

thick epidermis

endocrine/exocrine gland phenotype

abnormal sebocyte morphology
- although some early sebaceous differentiation occurs, sebocytes appear small and their cytoplasm is brightly eosinophilic, unlike wild-type cells

sebaceous gland hypoplasia
- extreme sebaceous gland hypoplasia

small Meibomian gland
- small

small perianal sebaceous gland

small sebaceous gland
- at day 6 mice have very small sebaceous glands compared to in wild-type mice
- Normal - however, preputial, clitoral, lingual, Harderian and lacrimal glands are normal
- mice have small Meibomian, perianal and cerimous glands

renal/urinary system phenotype

polyuria
- urine output is increased by 2% compared to in wild-type mice

vision/eye phenotype

small Meibomian gland
- small

References

Additional - Scd1^ab-2J related

Technical Support

CONTACT TECHNICAL SUPPORT

Genotyping Protocols
- Genotyping resources and troubleshooting
Breeding Considerations

The homozygotes are very poor breeders and the mutation is best maintained using heterozygous females bred to homozygous males.
- Additional Breeding and Husbandry Support
Citation
When using the asebia 2 Jackson mouse strain in a publication, please cite the originating article(s) and include JAX stock #005956 in your Materials and Methods section.

Animal Health Reports

Facility Barrier Level Descriptions

MGL277 (Low)

Pricing & Availability

Availability Varies

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.

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Also Known As:asebia 2 Jackson

Genetic overview

Research Applications

Base Price

Detailed Description

Control Suggestions

Additional Information

Scd1ab-2J

Allele Symbol: Scd1ab-2J

Disease Terms

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Genotype: Scd1ab-2J related

Mammalian Phenotype Terms by Genotype

Genotype: Scd1ab-2J/Scd1ab-2JDBA/1LacJ-Scd1/J

behavior/neurological phenotype

homeostasis/metabolism phenotype

immune system phenotype

integument phenotype

endocrine/exocrine gland phenotype

renal/urinary system phenotype

vision/eye phenotype

References

Additional - Scd1ab-2J related

Genotyping Protocols

Breeding Considerations

Citation

Animal Health Reports

Live Mouse

Cryorecovery - Pricing

Payment Terms and Conditions

The Jackson Laboratory's Genotype Promise

Terms Of Use

Licensing Information

JAX® Mice, Products & Services Conditions of Use

No Warranty

Credit for PRODUCTS or SERVICES

Animal Care and Use for SERVICES

No Liability

Scd1^ab-2J

Allele Symbol: Scd1^ab-2J

Genotype: Scd1^ab-2J related

Genotype: Scd1^ab-2J/Scd1^ab-2J
DBA/1LacJ-Scd1/J

Additional - Scd1^ab-2J related