JAX
Mouse Strain Datasheet - 005867
B6.129-Ido1tm1Alm/J
Also Known As: IDO KO
The lack of endogenous protein in homozygotes of these indoleamine 2,3-dioxygenase 1 knock-out mice affects immune and a number of other physiological responses. These mice may be useful in studies of pregnancy and reproductive immunology, as well as other immune response and physiological processes.
Donating Investigator
Andrew Mellor, Medical College of Georgia
Genetic overview
| Genetic Background | Generation |
|---|---|
|
N10+N1pN1F10
|
Ido1tm1Alm
| Allele Type | Gene Symbol | Gene Name |
|---|---|---|
| Targeted (Null/Knockout) | Ido1 | indoleamine 2,3-dioxygenase 1 |
Research Applications
- Immunology, Inflammation and Autoimmunity Research
- Research Tools
Detailed Description
Homozygous mice are viable and fertile with normal immune system development and function. They exhibit no spontaneous autoimmune disorders. No gene product (mRNA or protein) from the targeted gene is detected in the epididymis. At embryonic day 10.5, endogenous protein is absent from all cells at the maternal-fetal interface when both parents are homozygous for the targeted gene. Allogeneic and syngeneic pregnancy outcomes are unaffected by this mutation. In contrast to wild-type, anti-proliferative treatments (CTLA4-Ig, IFNalpha, or CpG-ODN) do not suppress T cell expansion both in vivo and in vitro. In addition, homozygous dendritic cells isolated from lymph nodes draining (induced) tumor sites have no suppressor activity. These mice may be useful in studies of pregnancy and reproductive immunology (tryptophan degradation, T cell activation, clonal expansion) as well as autoimmune disease, tissue transplantation, fostering, acquired tolerance/T cell anergy, and immunosuppressive pathways.
Development
A targeting vector was designed to replace exons 3-5 (encode critical portions of the enzyme catalytic site) with the beta-galactosidase and neomycin resistance genes. Additionally, a translational "stop" codon (TAG) was introduced into exon 2. The construct was electroporated into 129/SvJ-derived embryonic stem (ES) cells and correctly targeted clones were injected into blastocysts. Male chimeric mice were mated with C57BL/6 females to produce heterozygotes. Mutant mice were backcrossed more than 10 generations to C57BL/6 before arriving at The Jackson Laboratory.
Control Suggestions
Selected References
- Baban B; Chandler P; McCool D; Marshall B; Munn DH; Mellor AL. 2004. Indoleamine 2,3-dioxygenase expression is restricted to fetal trophoblast giant cells during murine gestation and is maternal genome specific. J Reprod Immunol 61(2):67-77. PubMed: 15063630MGI: J:93797
Ido1tm1Alm
Allele Symbol: Ido1tm1Alm
| Allele Name | targeted mutation 1, Andrew L Mellor |
|---|---|
| Allele Type | Targeted (Null/Knockout) |
| Allele Synonym(s) | IDO-; Ido1-KO; Ido1- |
| Gene Symbol and Name | Ido1, indoleamine 2,3-dioxygenase 1 |
| Gene Synonym(s) | IDO; IDO-1; INDO; Ido; Ido; Indo; Indo; indole 2,3-dioxygenase; indole 2,4-dioxygenase; indoleamine-pyrrole 2,3 dioxygenase |
| Strain of Origin | 129X1/SvJ |
| Chromosome | 8 |
| Molecular Note | A Betagal and neomycin cassette replaced exons 3-5, which encode critical portions of the enzyme catalytic site. Also, a translation stop codon was introduced into exon 2. RT-PCR of total epididymis RNA from mutants showed no transcript was present. Western blot of mutant epididymis confirmed a lack of protein. |
| Mutations Made By | Brendan Marshall, Medical College of Georgia |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Immunology, Inflammation and Autoimmunity Research
- Autoimmunity
- Immunodeficiency
- T cell deficiency
- Research Tools
- Cancer Research
- B and T cell deficiency, xenograft/transplant host
- Immunology, Inflammation and Autoimmunity Research
- T cell deficiency, xenograft/transplant host
- Reproductive Biology Research
- Cancer Research
Mammalian Phenotype Terms by Genotype
The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain
Genotype: Ido1tm1Alm/Ido1tm1Alm
involves: 129X1/SvJ * BALB/c
reproductive system phenotype
- abnormal caput epididymis morphology
- abnormal sperm number
- caudal epididymal sperm counts are nearly twice as high in mutants as in wild-type males (MGI Ref ID J:170565)
- enlarged sperm head
- (MGI Ref ID J:170565)
- epididymal inflammation
- whereas wild-type caput epididymis exhibits a high KYN/Trp ratio indicating that it is in an immunosuppressed state, mutants have a much lower KYN/Trp ratio, indicating that the caput epididymis is in an inflammatory state (MGI Ref ID J:170565)
- hairpin sperm flagellum
- (MGI Ref ID J:170565)
- pinhead sperm
- (MGI Ref ID J:170565)
- reproductive system phenotype
- males exhibit normal fertility and testis weight (MGI Ref ID J:170565)
- teratozoospermia
- increase in the proportion of spermatozoa exhibiting abnormal morphology, including pinhead, giant head, hairpin and kite spermatozoa (MGI Ref ID J:170565)
cellular phenotype
- abnormal autophagy
- lysosomal autophagy is seen in mutant but not wild-type caput epididymal tissues as indicated by an increase in multilamellar/multivesicular bodies (MGI Ref ID J:170565)
- enlarged sperm head
- (MGI Ref ID J:170565)
- hairpin sperm flagellum
- (MGI Ref ID J:170565)
- pinhead sperm
- (MGI Ref ID J:170565)
- teratozoospermia
- increase in the proportion of spermatozoa exhibiting abnormal morphology, including pinhead, giant head, hairpin and kite spermatozoa (MGI Ref ID J:170565)
hematopoietic system phenotype
- decreased leukocyte cell number
- decrease in leukocyte count in caudal epididymal fluid (MGI Ref ID J:170565)
homeostasis/metabolism phenotype
- abnormal cytokine level
- levels of some cytokines are higher in mutant caput epididymis (MGI Ref ID J:170565)
- abnormal protein level
- significantly greater amounts of protein in caput epididymis extracts than in controls due to decreased protein degradation (MGI Ref ID J:170565)
immune system phenotype
- abnormal cytokine level
- levels of some cytokines are higher in mutant caput epididymis (MGI Ref ID J:170565)
- decreased leukocyte cell number
- decrease in leukocyte count in caudal epididymal fluid (MGI Ref ID J:170565)
- epididymal inflammation
- whereas wild-type caput epididymis exhibits a high KYN/Trp ratio indicating that it is in an immunosuppressed state, mutants have a much lower KYN/Trp ratio, indicating that the caput epididymis is in an inflammatory state (MGI Ref ID J:170565)
Genotype: Ido1tm1Alm/Ido1tm1Alm
involves: 129X1/SvJ * C57BL/6J * FVB/N
immune system phenotype
- decreased susceptibility to type IV hypersensitivity reaction
- reduced ear swelling in a contact hypersensitivity assay with oxazolone (MGI Ref ID J:211949)
- increased interferon-gamma secretion
- increased interleukin-6 secretion
Genotype: Ido1tm1Alm/Ido1tm1Alm
involves: 129X1/SvJ
homeostasis/metabolism phenotype
- homeostasis/metabolism phenotype
- tryptophan plasma levels are normal (MGI Ref ID J:177903)
Genotype: Ido1tm1Alm/Ido1tm1Alm
either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * CBA)
reproductive system phenotype
- reproductive system phenotype
- no effect on reproductive success (MGI Ref ID J:93797)
References
- Baban B; Chandler P; McCool D; Marshall B; Munn DH; Mellor AL. 2004. Indoleamine 2,3-dioxygenase expression is restricted to fetal trophoblast giant cells during murine gestation and is maternal genome specific. J Reprod Immunol 61(2):67-77. PubMed: 15063630MGI: J:93797
Additional - Ido1tm1Alm related
- Baban B; Chandler PR; Sharma MD; Pihkala J; Koni PA; Munn DH; Mellor AL. 2009. IDO activates regulatory T cells and blocks their conversion into Th17-like T cells. J Immunol 183(4):2475-83. PubMed: 19635913MGI: J:151475
- Baban B; Hansen AM; Chandler PR; Manlapat A; Bingaman A; Kahler DJ; Munn DH; Mellor AL. 2005. A minor population of splenic dendritic cells expressing CD19 mediates IDO-dependent T cell suppression via type I IFN signaling following B7 ligation. Int Immunol 17(7):909-19. PubMed: 15967784MGI: J:99971
- Bessede A; Gargaro M; Pallotta MT; Matino D; Servillo G; Brunacci C; Bicciato S; Mazza EM; Macchiarulo A; Vacca C; Iannitti R; Tissi L; Volpi C; Belladonna ML; Orabona C; Bianchi R; Lanz TV; Platten M; Della Fazia MA; Piobbico D; Zelante T; Funakoshi H; Nakamura T; Gilot D; Denison MS; Guillemin GJ; DuHadaway JB; Prendergast GC; Metz R; Geffard M; Boon L; Pirro M; Iorio A; Veyret B; Romani L; Grohmann U; Fallarino F; Puccetti P. 2014. Aryl hydrocarbon receptor control of a disease tolerance defence pathway. Nature 511(7508):184-90. PubMed: 24930766MGI: J:213564
- Blumenthal A; Nagalingam G; Huch JH; Walker L; Guillemin GJ; Smythe GA; Ehrt S; Britton WJ; Saunders BM. 2012. M. tuberculosis induces potent activation of IDO-1, but this is not essential for the immunological control of infection. PLoS One 7(5):e37314. PubMed: 22649518MGI: J:187311
- Bonifazi P; D'Angelo C; Zagarella S; Zelante T; Bozza S; De Luca A; Giovannini G; Moretti S; Iannitti RG; Fallarino F; Carvalho A; Cunha C; Bistoni F; Romani L. 2010. Intranasally delivered siRNA targeting PI3K/Akt/mTOR inflammatory pathways protects from aspergillosis. Mucosal Immunol 3(2):193-205. PubMed: 19924119MGI: J:194658
- Centuori SM; Trad M; LaCasse CJ; Alizadeh D; Larmonier CB; Hanke NT; Kartchner J; Janikashvili N; Bonnotte B; Larmonier N; Katsanis E. 2012. Myeloid-derived suppressor cells from tumor-bearing mice impair TGF-beta-induced differentiation of CD4+CD25+FoxP3+ Tregs from CD4+CD25-FoxP3- T cells. J Leukoc Biol 92(5):987-97. PubMed: 22891289MGI: J:189810
- Cobbold SP; Adams E; Farquhar CA; Nolan KF; Howie D; Lui KO; Fairchild PJ; Mellor AL; Ron D; Waldmann H. 2009. Infectious tolerance via the consumption of essential amino acids and mTOR signaling. Proc Natl Acad Sci U S A 106(29):12055-60. PubMed: 19567830MGI: J:150809
- Fukunaga M; Yamamoto Y; Kawasoe M; Arioka Y; Murakami Y; Hoshi M; Saito K. 2012. Studies on tissue and cellular distribution of indoleamine 2,3-dioxygenase 2: the absence of IDO1 upregulates IDO2 expression in the epididymis. J Histochem Cytochem 60(11):854-60. PubMed: 22895526MGI: J:214281
- Harrington L; Srikanth CV; Antony R; Rhee SJ; Mellor AL; Shi HN; Cherayil BJ. 2008. Deficiency of indoleamine 2,3-dioxygenase enhances commensal-induced antibody responses and protects against Citrobacter rodentium-induced colitis. Infect Immun 76(7):3045-53. PubMed: 18426872MGI: J:137302
- Heisler JM; O'Connor JC. 2015. Indoleamine 2,3-dioxygenase-dependent neurotoxic kynurenine metabolism mediates inflammation-induced deficit in recognition memory. Brain Behav Immun 50:115-24. PubMed: 26130057MGI: J:238320
- Holmgaard RB; Zamarin D; Munn DH; Wolchok JD; Allison JP. 2013. Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4. J Exp Med 210(7):1389-402. PubMed: 23752227MGI: J:201770
- Hoshi M; Matsumoto K; Ito H; Ohtaki H; Arioka Y; Osawa Y; Yamamoto Y; Matsunami H; Hara A; Seishima M; Saito K. 2012. L-tryptophan-kynurenine pathway metabolites regulate type I IFNs of acute viral myocarditis in mice. J Immunol 188(8):3980-7. PubMed: 22422885MGI: J:184065
- Hoshi M; Saito K; Hara A; Taguchi A; Ohtaki H; Tanaka R; Fujigaki H; Osawa Y; Takemura M; Matsunami H; Ito H; Seishima M. 2010. The absence of IDO upregulates type I IFN production, resulting in suppression of viral replication in the retrovirus-infected mouse. J Immunol 185(6):3305-12. PubMed: 20693424MGI: J:163841
- Huang L; Li L; Klonowski KD; Tompkins SM; Tripp RA; Mellor AL. 2013. Induction and role of indoleamine 2,3 dioxygenase in mouse models of influenza a virus infection. PLoS One 8(6):e66546. PubMed: 23785507MGI: J:203475
- Ito H; Ando T; Ando K; Ishikawa T; Saito K; Moriwaki H; Seishima M. 2014. Induction of hepatitis B virus surface antigen-specific cytotoxic T lymphocytes can be up-regulated by the inhibition of indoleamine 2, 3-dioxygenase activity. Immunology 142(4):614-23. PubMed: 24580128MGI: J:218577
- Ito H; Hoshi M; Ohtaki H; Taguchi A; Ando K; Ishikawa T; Osawa Y; Hara A; Moriwaki H; Saito K; Seishima M. 2010. Ability of IDO to attenuate liver injury in alpha-galactosylceramide-induced hepatitis model. J Immunol 185(8):4554-60. PubMed: 20844202MGI: J:164734
- Jasperson LK; Bucher C; Panoskaltsis-Mortari A; Mellor AL; Munn DH; Blazar BR. 2009. Inducing the tryptophan catabolic pathway, indoleamine 2,3-dioxygenase (IDO), for suppression of graft-versus-host disease (GVHD) lethality. Blood 114(24):5062-70. PubMed: 19828695MGI: J:155467
- Jasperson LK; Bucher C; Panoskaltsis-Mortari A; Taylor PA; Mellor AL; Munn DH; Blazar BR. 2008. Indoleamine 2,3-dioxygenase is a critical regulator of acute graft-versus-host disease lethality. Blood 111(6):3257-65. PubMed: 18077788MGI: J:132719
- Jrad-Lamine A; Henry-Berger J; Damon-Soubeyrand C; Saez F; Kocer A; Janny L; Pons-Rejraji H; Munn DH; Mellor AL; Gharbi N; Cadet R; Guiton R; Aitken RJ; Drevet JR. 2013. Indoleamine 2,3-dioxygenase 1 (ido1) is involved in the control of mouse caput epididymis immune environment. PLoS One 8(6):e66494. PubMed: 23840489MGI: J:204333
- Jrad-Lamine A; Henry-Berger J; Gourbeyre P; Damon-Soubeyrand C; Lenoir A; Combaret L; Saez F; Kocer A; Tone S; Fuchs D; Zhu W; Oefner PJ; Munn DH; Mellor AL; Gharbi N; Cadet R; Aitken RJ; Drevet JR. 2011. Deficient tryptophan catabolism along the kynurenine pathway reveals that the epididymis is in a unique tolerogenic state. J Biol Chem 286(10):8030-42. PubMed: 21189261MGI: J:170565
- Jung ID; Lee MG; Chang JH; Lee JS; Jeong YI; Lee CM; Park WS; Han J; Seo SK; Lee SY; Park YM. 2009. Blockade of indoleamine 2,3-dioxygenase protects mice against lipopolysaccharide-induced endotoxin shock. J Immunol 182(5):3146-54. PubMed: 19234212MGI: J:146236
- Kanai M; Funakoshi H; Takahashi H; Hayakawa T; Mizuno S; Matsumoto K; Nakamura T. 2009. Tryptophan 2,3-dioxygenase is a key modulator of physiological neurogenesis and anxiety-related behavior in mice. Mol Brain 2:8. PubMed: 19323847MGI: J:177903
- Kim H; Chen L; Lim G; Sung B; Wang S; McCabe MF; Rusanescu G; Yang L; Tian Y; Mao J. 2012. Brain indoleamine 2,3-dioxygenase contributes to the comorbidity of pain and depression. J Clin Invest 122(8):2940-54. PubMed: 22751107MGI: J:190079
- Lee J; Lee J; Park MK; Lim MA; Park EM; Kim EK; Yang EJ; Lee SY; Jhun JY; Park SH; Kim HY; Cho ML. 2013. Interferon gamma suppresses collagen-induced arthritis by regulation of Th17 through the induction of indoleamine-2,3-deoxygenase. PLoS One 8(4):e60900. PubMed: 23613752MGI: J:200571
- Lemos H; Mohamed E; Huang L; Ou R; Pacholczyk G; Arbab AS; Munn D; Mellor AL. 2016. STING Promotes the Growth of Tumors Characterized by Low Antigenicity via IDO Activation. Cancer Res 76(8):2076-81. PubMed: 26964621MGI: J:231773
- Lu Y; Giver CR; Sharma A; Li JM; Darlak KA; Owens LM; Roback JD; Galipeau J; Waller EK. 2012. IFN-gamma and indoleamine 2,3-dioxygenase signaling between donor dendritic cells and T cells regulates graft versus host and graft versus leukemia activity. Blood 119(4):1075-85. PubMed: 22130799MGI: J:181750
- Maazi H; Shirinbak S; den Boef LE; Fallarino F; Volpi C; Nawijn MC; van Oosterhout AJ. 2013. Cytotoxic T lymphocyte antigen 4-immunoglobulin G is a potent adjuvant for experimental allergen immunotherapy. Clin Exp Immunol 172(1):113-20. PubMed: 23480191MGI: J:194897
- Manlapat AK; Kahler DJ; Chandler PR; Munn DH; Mellor AL. 2007. Cell-autonomous control of interferon type I expression by indoleamine 2,3-dioxygenase in regulatory CD19+ dendritic cells. Eur J Immunol 37(4):1064-71. PubMed: 17343295MGI: J:120813
- Masoumy M; Yu J; Liu JY; Yanasak N; Middleton C; Lamoke F; Mozaffari MS; Baban B. 2014. The role of indoleamine 2,3 dioxygenase in beneficial effects of stem cells in hind limb ischemia reperfusion injury. PLoS One 9(4):e95720. PubMed: 24752324MGI: J:215178
- Mazarei G; Budac DP; Lu G; Lee H; Moller T; Leavitt BR. 2013. The absence of indoleamine 2,3-dioxygenase expression protects against NMDA receptor-mediated excitotoxicity in mouse brain. Exp Neurol 249:144-8. PubMed: 23994717MGI: J:203830
- Mellor AL; Baban B; Chandler P; Marshall B; Jhaver K; Hansen A; Koni PA; Iwashima M; Munn DH. 2003. Cutting edge: induced indoleamine 2,3 dioxygenase expression in dendritic cell subsets suppresses T cell clonal expansion. J Immunol 171(4):1652-5. PubMed: 12902462MGI: J:93796
- Mellor AL; Baban B; Chandler PR; Manlapat A; Kahler DJ; Munn DH. 2005. Cutting edge: CpG oligonucleotides induce splenic CD19+ dendritic cells to acquire potent indoleamine 2,3-dioxygenase-dependent T cell regulatory functions via IFN Type 1 signaling. J Immunol 175(9):5601-5. PubMed: 16237046MGI: J:119367
- Mellor AL; Chandler P; Baban B; Hansen AM; Marshall B; Pihkala J; Waldmann H; Cobbold S; Adams E; Munn DH. 2004. Specific subsets of murine dendritic cells acquire potent T cell regulatory functions following CTLA4-mediated induction of indoleamine 2,3 dioxygenase. Int Immunol 16(10):1391-401. PubMed: 15351783MGI: J:93639
- Merlo LM; Pigott E; DuHadaway JB; Grabler S; Metz R; Prendergast GC; Mandik-Nayak L. 2014. IDO2 is a critical mediator of autoantibody production and inflammatory pathogenesis in a mouse model of autoimmune arthritis. J Immunol 192(5):2082-90. PubMed: 24489090MGI: J:209940
- Metghalchi S; Ponnuswamy P; Simon T; Haddad Y; Laurans L; Clement M; Dalloz M; Romain M; Esposito B; Koropoulis V; Lamas B; Paul JL; Cottin Y; Kotti S; Bruneval P; Callebert J; den Ruijter H; Launay JM; Danchin N; Sokol H; Tedgui A; Taleb S; Mallat Z. 2015. Indoleamine 2,3-Dioxygenase Fine-Tunes Immune Homeostasis in Atherosclerosis and Colitis through Repression of Interleukin-10 Production. Cell Metab 22(3):460-71. PubMed: 26235422MGI: J:228095
- Metz R; Smith C; DuHadaway JB; Chandler P; Baban B; Merlo LM; Pigott E; Keough MP; Rust S; Mellor AL; Mandik-Nayak L; Muller AJ; Prendergast GC. 2014. IDO2 is critical for IDO1-mediated T-cell regulation and exerts a non-redundant function in inflammation. Int Immunol 26(7):357-67. PubMed: 24402311MGI: J:211949
- Mohib K; Wang S; Guan Q; Mellor AL; Sun H; Du C; Jevnikar AM. 2008. Indoleamine 2,3-dioxygenase expression promotes renal ischemia-reperfusion injury. Am J Physiol Renal Physiol 295(1):F226-34. PubMed: 18480171MGI: J:148645
- Moyer BJ; Rojas IY; Kerley-Hamilton JS; Hazlett HF; Nemani KV; Trask HW; West RJ; Lupien LE; Collins AJ; Ringelberg CS; Gimi B; Kinlaw WB 3rd; Tomlinson CR. 2016. Inhibition of the aryl hydrocarbon receptor prevents Western diet-induced obesity. Model for AHR activation by kynurenine via oxidized-LDL, TLR2/4, TGFbeta, and IDO1. Toxicol Appl Pharmacol 300:13-24. PubMed: 27020609MGI: J:234506
- Muller AJ; DuHadaway JB; Jaller D; Curtis P; Metz R; Prendergast GC. 2010. Immunotherapeutic suppression of indoleamine 2,3-dioxygenase and tumor growth with ethyl pyruvate. Cancer Res 70(5):1845-53. PubMed: 20160032MGI: J:158003
- Muller AJ; Sharma MD; Chandler PR; Duhadaway JB; Everhart ME; Johnson BA 3rd; Kahler DJ; Pihkala J; Soler AP; Munn DH; Prendergast GC; Mellor AL. 2008. Chronic inflammation that facilitates tumor progression creates local immune suppression by inducing indoleamine 2,3 dioxygenase. Proc Natl Acad Sci U S A 105(44):17073-8. PubMed: 18952840MGI: J:144863
- Nagano J; Shimizu M; Hara T; Shirakami Y; Kochi T; Nakamura N; Ohtaki H; Ito H; Tanaka T; Tsurumi H; Saito K; Seishima M; Moriwaki H. 2013. Effects of indoleamine 2,3-dioxygenase deficiency on high-fat diet-induced hepatic inflammation. PLoS One 8(9):e73404. PubMed: 24039933MGI: J:207350
- Noh KT; Chae SH; Chun SH; Jung ID; Kang HK; Park YM. 2013. Resveratrol suppresses tumor progression via the regulation of indoleamine 2,3-dioxygenase. Biochem Biophys Res Commun 431(2):348-53. PubMed: 23291179MGI: J:198077
- Noh KT; Jung ID; Cha GS; Han MK; Park YM. 2017. Platelet-activating Factor Mediates Endotoxin Tolerance by Regulating Indoleamine 2,3-Dioxygenase-dependent Expression of the Suppressor of Cytokine Signaling 3. J Biol Chem 292(8):3290-3298. PubMed: 28077574MGI: J:241084
- O'Connor JC; Lawson MA; Andre C; Briley EM; Szegedi SS; Lestage J; Castanon N; Herkenham M; Dantzer R; Kelley KW. 2009. Induction of IDO by bacille Calmette-Guerin is responsible for development of murine depressive-like behavior. J Immunol 182(5):3202-12. PubMed: 19234218MGI: J:146234
- Ohtaki H; Ito H; Ando K; Ishikawa T; Hoshi M; Ando T; Takamatsu M; Hara A; Moriwaki H; Saito K; Seishima M. 2014. Kynurenine production mediated by indoleamine 2,3-dioxygenase aggravates liver injury in HBV-specific CTL-induced fulminant hepatitis. Biochim Biophys Acta 1842(9):1464-71. PubMed: 24768802MGI: J:217041
- Ohtaki H; Ito H; Ando K; Ishikawa T; Hoshi M; Tanaka R; Osawa Y; Yokochi T; Moriwaki H; Saito K; Seishima M. 2009. Interaction between LPS-induced NO production and IDO activity in mouse peritoneal cells in the presence of activated Valpha14 NKT cells. Biochem Biophys Res Commun 389(2):229-34. PubMed: 19715679MGI: J:154077
- Pallotta MT; Orabona C; Volpi C; Vacca C; Belladonna ML; Bianchi R; Servillo G; Brunacci C; Calvitti M; Bicciato S; Mazza EM; Boon L; Grassi F; Fioretti MC; Fallarino F; Puccetti P; Grohmann U. 2011. Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells. Nat Immunol 12(9):870-8. PubMed: 21804557MGI: J:176469
- Peng K; Monack DM. 2010. Indoleamine 2,3-dioxygenase 1 is a lung-specific innate immune defense mechanism that inhibits growth of Francisella tularensis tryptophan auxotrophs. Infect Immun 78(6):2723-33. PubMed: 20385761MGI: J:160167
- Ravishankar B; Liu H; Shinde R; Chandler P; Baban B; Tanaka M; Munn DH; Mellor AL; Karlsson MC; McGaha TL. 2012. Tolerance to apoptotic cells is regulated by indoleamine 2,3-dioxygenase. Proc Natl Acad Sci U S A 109(10):3909-14. PubMed: 22355111MGI: J:182142
- Riella LV; Dada S; Chabtini L; Smith B; Huang L; Dakle P; Mfarrej B; D'Addio F; Adams LT; Kochupurakkal N; Vergani A; Fiorina P; Mellor AL; Sharpe AH; Yagita H; Guleria I. 2013. B7h (ICOS-L) maintains tolerance at the fetomaternal interface. Am J Pathol 182(6):2204-13. PubMed: 23578385MGI: J:198478
- Rytelewski M; Meilleur CE; Yekta MA; Szabo PA; Garg N; Schell TD; Jevnikar AM; Sharif S; Singh B; Haeryfar SM. 2014. Suppression of immunodominant antitumor and antiviral CD8+ T cell responses by indoleamine 2,3-dioxygenase. PLoS One 9(2):e90439. PubMed: 24587363MGI: J:214465
- Sharma MD; Baban B; Chandler P; Hou DY; Singh N; Yagita H; Azuma M; Blazar BR; Mellor AL; Munn DH. 2007. Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase. J Clin Invest 117(9):2570-82. PubMed: 17710230MGI: J:127409
- Sharma MD; Hou DY; Liu Y; Koni PA; Metz R; Chandler P; Mellor AL; He Y; Munn DH. 2009. Indoleamine 2,3-dioxygenase controls conversion of Foxp3+ Tregs to TH17-like cells in tumor-draining lymph nodes. Blood 113(24):6102-11. PubMed: 19366986MGI: J:149490
- Smith C; Chang MY; Parker KH; Beury DW; DuHadaway JB; Flick HE; Boulden J; Sutanto-Ward E; Soler AP; Laury-Kleintop LD; Mandik-Nayak L; Metz R; Ostrand-Rosenberg S; Prendergast GC; Muller AJ. 2012. IDO is a nodal pathogenic driver of lung cancer and metastasis development. Cancer Discov 2(8):722-35. PubMed: 22822050MGI: J:193156
- Sumpter TL; Dangi A; Matta BM; Huang C; Stolz DB; Vodovotz Y; Thomson AW; Gandhi CR. 2012. Hepatic stellate cells undermine the allostimulatory function of liver myeloid dendritic cells via STAT3-dependent induction of IDO. J Immunol 189(8):3848-58. PubMed: 22962681MGI: J:190536
- Takamatsu M; Hirata A; Ohtaki H; Hoshi M; Hatano Y; Tomita H; Kuno T; Saito K; Hara A. 2013. IDO1 plays an immunosuppressive role in 2,4,6-trinitrobenzene sulfate-induced colitis in mice. J Immunol 191(6):3057-64. PubMed: 23956437MGI: J:205871
- Tawara I; Shlomchik WD; Jones A; Zou W; Nieves E; Liu C; Toubai T; Duran-Struuck R; Sun Y; Clouthier SG; Evers R; Lowler KP; Levy RB; Reddy P. 2010. A crucial role for host APCs in the induction of donor CD4+CD25+ regulatory T cell-mediated suppression of experimental graft-versus-host disease. J Immunol 185(7):3866-72. PubMed: 20810991MGI: J:164307
- Too LK; McQuillan JA; Ball HJ; Kanai M; Nakamura T; Funakoshi H; McGregor IS; Hunt NH. 2014. The kynurenine pathway contributes to long-term neuropsychological changes in experimental pneumococcal meningitis. Behav Brain Res 270:179-95. PubMed: 24844751MGI: J:216882
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