Homozygotes are viable with diminished fertility. A truncated transcript encoding of the first 120 amino acids followed by 63 extra residues is expressed in brain tissue. Antibodies against C terminal epitopes show no endogenous protein. Homozygous mice have complex neurological and behavioral impairments including tonic-clonic seizures and increased locomotor activity after handling. Compared to wildtype, mutant mice have significantly diminished adaptor complex 3 (AP-3) in dendritic processes and 62% less presynaptic zinc storage in the CA1 stratum oriens (total 25% decrease throughout the brain). The synaptic vesicle targeting of membrane proteins involved in zinc uptake (ZnT3 and ClC-3) is compromised. This mutant may be useful in studies of neuron biology, specifically membrane protein assembly and storage in synaptic vesicles.

These <i> Ap3b2</i> knock-out mice exhibit complex neurological and behavioral impairments and are suitable for use in applications related to the study of neuron biology.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

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