This transgenic strain carries a rearranged T cell receptor that recognizes a complex consisting of a short peptide derived from the H2-Ea gene (Ealpha52-68) and the H2-Ab gene product (IAb). This mouse lacks naturally occurring Ealpha52-68 peptide as the H2-Ea gene in C57BL/6J mice is incapable of expressing a protein product. Flow cytometric analysis shows 90% and 95% of CD4+ splenocytes expressing Tcra-V2 and Tcrb-V6, respectively. Mice that are hemizygous for these transgenes are viable, fertile and normal in size. This mutant mouse may be useful in studies of positive/negative selection, T cell receptor interactions, or graft-versus-host disease.

These TEa Tg mice express a transgene containing a rearranged T cell receptor that recognizes an H2-Ea/H2-Ab complex.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

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