This strain is homozygous for the retinal degeneration allele Pde6brd1.
This SJL/J congenic strain carries the T lymphocyte specific Thy1a (Thy1.1) allele. Donor T cells can be easily distinguished from recipient T cells by both flow cytometric and histological analysis. SJL/J mice are a model of experimental autoimmune encephalomyelitis (EAE). This congenic is useful for EAE research requiring an adoptive transfer system.
The donating investigator, Dr. Harley Y. Tse, backcrossed this congenic 12 times and then intercrossed to produce Thy1a homozygotes. Thy1a mice were selected using flow cytometry. The incross (F) generation number is unknown. The strain was cryopreserved as embryos in 1995. The embryos were donated to The Jackson Laboratory in 2005.
|Allele Name||a variant|
|Allele Type||Not Applicable|
|Allele Synonym(s)||thetaAKR; theta-AKR; Thy1.1; Thy-1.1; Thy1a|
|Gene Symbol and Name||Thy1, thymus cell antigen 1, theta|
|Site of Expression||The Thy1 locus determines a surface antigen present on cells of the thymus, a number of mouse leukemias, brain, and in lesser amounts on lymph node and spleen cells.|
|Strain of Origin||Not Applicable|
|General Note|| |
The Thy1 locus determines a surface antigen present on cells of the thymus, a number of mouse leukemias, brain, and in lesser amounts on lymph node and spleen cells. The allele Thy1a determines an antigenic specificity, Thy-1.1, found in the AKR and RF strains; the allele Thy1b determines an antigenic specificity, Thy-1.2, found in the C3HeB/Fe and many other strains (J:5243, J:5012, J:4469). The Thy1 antigen is probably present on all T lymphocytes and absent from all B lymphocytes, and it thus serves as a valuable T-cell marker (J:5243). It is very widely used in experiments designed to determine the distribution and function of T-cells. Thy1 specifies a T-cell surface glycoprotein, T25, with a molecular weight of 25 kDa (J:5707). The protein appears to be anchored in the cell membrane by a lipid that is either phosphotidylinositol or closely related to it (J:12016). Thy1 may function in the cell membrane as a signal transduction molecule (J:8333). The Thy1 locus, or possibly a gene closely linked to it, controls quantitative expression of a protein that is the same size as Thy1 and is expressed on thymus and brain but not on lymph node and spleen cells (J:7900).
|Molecular Note||The allele Thy1a determines an antigenic specificity, Thy-1.1, found in the AKR and RF strains.|
When using the SJL.AK-Thy1a/TseJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #005651 in your Materials and Methods section.