JAX Mouse Strain Datasheet - 005628

B6.129S2-Emx1^tm1(cre)Krj/J

Stock No:: 005628 |; Emx1^{IRES cre}

Repository Live

Overview

Also Known As: Emx1^{IRES cre}

Emx1-IRES-Cre knockin mice have the endogenous Emx1 locus directing expression of Cre recombinase to approximately 88% of the neurons of the neocortex and hippocampus, and in the glial cells of the pallium. These mice are useful in studies of forebrain development and function.

Donating Investigator

Kevin R. Jones, University of Colorado- Boulder

Genetic overview

Genetic Background	Generation
	N12+N1F11 (03-APR-17)

Emx1^tm1(cre)Krj

Allele Type	Gene Symbol	Gene Name
Targeted (Recombinase-expressing)	Emx1	empty spiracles homeobox 1

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Research Applications

Neurobiology Research
Research Tools

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Base Price

Starting at:

$255.00 Domestic price for female

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Details

Detailed Description

Mice homozygous for the targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. This strain expresses Cre recombinase from the endogenous Emx1 locus. Western blot analysis of cortical brain tissue does not detect reduced endogenous gene product (protein). When crossed with a strain containing a loxP-site flanked sequence, Cre-mediated recombination results in tissue-specific deletion of the flanked sequence. Recombination occurs in approximately 88% of the neurons of the neocortex and hippocampus, and in the glial cells of the pallium, mimicking the pattern of expression of the endogenous gene. Further, the donating investigator reports that Cre recombinase is also expressed in a subset of male germline cells, thus some offspring from a cre; floxed male will have the floxed allele recombined in all cells. Our findings suggest that females may also be similarly affected. This mutant mouse strain represents a model that may be useful in studies of forebrain development and function.

View cre expression characterization.

Development

A targeting vector containing an internal ribosome entry site (IRES) sequence, Cre coding sequence, a polyadenlyation signal and a FRT site flanked PGK-neomycin cassette was inserted 120bp 3' from the stop codon, in the 3' untranslated region. The construct was electroporated into 129S2/SvPas derived D3 embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient blastocysts. The resulting chimeric animal was crossed to a Flp recombinase expressing strain (FLP-4917) to remove the selection cassette. The mice were then backcrossed to C57BL/6 mice for 12 generations.

Expression Data

Expressed Gene	cre, cre recombinase, bacteriophage P1
Site of Expression	neurons of the neocortex and hippocampus; some germline

Control Suggestions

000664 C57BL/6J

Additional Information

Considerations for Choosing Controls

Selected References

Gorski JA; Talley T; Qiu M; Puelles L; Rubenstein JL; Jones KR. 2002. Cortical excitatory neurons and glia, but not GABAergic neurons, are produced in the Emx1-expressing lineage. J Neurosci 22(15):6309-14. PubMed: 12151506 MGI: J:78098

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Genetics

Emx1^tm1(cre)Krj

Allele Symbol: Emx1^tm1(cre)Krj

Allele Name	targeted mutation 1, Kevin R Jones
Allele Type	Targeted (Recombinase-expressing)
Allele Synonym(s)	Emx1-IRES-Cre; Emx1^Cre; Emx1^IREScre; emx1-cre
Gene Symbol and Name	Emx1, empty spiracles homeobox 1
Gene Synonym(s)	RGD1564002
Expressed Gene	cre, cre recombinase, bacteriophage P1
Site of Expression	neurons of the neocortex and hippocampus; some germline
Strain of Origin	129S2/SvPas
Chromosome	6
Molecular Note	An IRES-cre gene followed by an FRT flanked PGK-neomycin gene was inserted 120 bp 3' of the stop codon. The neomycin gene was later removed in vivo by crossing to an Flp recombinase expressing transgenic strain. The protein product of this gene was produced in normal quantities as confirmed by Western blot analysis. Cre recombinase expression was characterized by crossing to a Rosa26 strain.
Mutations Made By	Kevin Jones, University of Colorado- Boulder

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Neurobiology Research
- Cre-lox System
  - Cre Recombinase expression in neural tissue
- Neurodevelopmental Defects
Research Tools
- Cre-lox System
  - Cre Recombinase Expression
  - Cre Recombinase Expression: Germline/Embryonic Expression
- Developmental Biology Research
  - Cre-lox System
- Neurobiology Research

Genotype: cre related

Research Tools
- Cre-lox System
- Genetics Research
  - Mutagenesis and Transgenesis
  - Mutagenesis and Transgenesis: Cre-lox System

Mammalian Phenotype Terms by Genotype

The following phenotype information is associated with a similar, but not exact match to this JAX^® Mice strain

Genotype: Emx1^tm1(cre)Krj/Emx1^tm1(cre)Krj
involves: 129S2/SvPas * C57BL/6

normal phenotype

no abnormal phenotype detected
- homozygous mice do not show any of the abnormal phenotypes shown for Emx1^tm1Jlr homozygotes

References

Gorski JA; Talley T; Qiu M; Puelles L; Rubenstein JL; Jones KR. 2002. Cortical excitatory neurons and glia, but not GABAergic neurons, are produced in the Emx1-expressing lineage. J Neurosci 22(15):6309-14. PubMed: 12151506 MGI: J:78098

Additional - Emx1^tm1(cre)Krj related

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Ahmari SE; Spellman T; Douglass NL; Kheirbek MA; Simpson HB; Deisseroth K; Gordon JA; Hen R. 2013. Repeated cortico-striatal stimulation generates persistent OCD-like behavior. Science 340(6137):1234-9. PubMed: 23744948 MGI: J:199177
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Amaniti EM; Fu C; Lewis S; Saisana M; Magnani D; Mason JO; Theil T. 2015. Expansion of the piriform cortex contributes to corticothalamic pathfinding defects in Gli3 conditional mutants. Cereb Cortex 25(2):460-71. PubMed: 24014668 MGI: J:229226
Amaniti EM; Hasenpusch-Theil K; Li Z; Magnani D; Kessaris N; Mason JO; Theil T. 2013. Gli3 is required in Emx1(+) progenitors for the development of the corpus callosum. Dev Biol 376(2):113-24. PubMed: 23396189 MGI: J:195145
Antoine MW; Hubner CA; Arezzo JC; Hebert JM. 2013. A causative link between inner ear defects and long-term striatal dysfunction. Science 341(6150):1120-3. PubMed: 24009395 MGI: J:201156
Armentano M; Chou SJ; Tomassy GS; Leingartner A; O'Leary DD; Studer M. 2007. COUP-TFI regulates the balance of cortical patterning between frontal/motor and sensory areas. Nat Neurosci 10(10):1277-86. PubMed: 17828260 MGI: J:127387
Armour EA; Carson RP; Ess KC. 2012. Cystogenesis and elongated primary cilia in Tsc1-deficient distal convoluted tubules. Am J Physiol Renal Physiol 303(4):F584-92. PubMed: 22674026 MGI: J:188431
Asinof SK; Sukoff Rizzo SJ; Buckley AR; Beyer BJ; Letts VA; Frankel WN; Boumil RM. 2015. Independent Neuronal Origin of Seizures and Behavioral Comorbidities in an Animal Model of a Severe Childhood Genetic Epileptic Encephalopathy. PLoS Genet 11(6):e1005347. PubMed: 26125563 MGI: J:224850
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Depaepe V; Suarez-Gonzalez N; Dufour A; Passante L; Gorski JA; Jones KR; Ledent C; Vanderhaeghen P. 2005. Ephrin signalling controls brain size by regulating apoptosis of neural progenitors. Nature 435(7046):1244-50. PubMed: 15902206 MGI: J:99355
Ding Y; Qu Y; Feng J; Wang M; Han Q; So KF; Wu W; Zhou L. 2014. Functional motor recovery from motoneuron axotomy is compromised in mice with defective corticospinal projections. PLoS One 9(7):e101918. PubMed: 25003601 MGI: J:218923
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Dudok JJ; Murtaza M; Henrique Alves C; Rashbass P; Wijnholds J. 2016. Crumbs 2 prevents cortical abnormalities in mouse dorsal telencephalon. Neurosci Res 108:12-23. PubMed: 26802325 MGI: J:236353
Elia LP; Yamamoto M; Zang K; Reichardt LF. 2006. p120 catenin regulates dendritic spine and synapse development through Rho-family GTPases and cadherins. Neuron 51(1):43-56. PubMed: 16815331 MGI: J:110469
English CN; Vigers AJ; Jones KR. 2012. Genetic evidence that brain-derived neurotrophic factor mediates competitive interactions between individual cortical neurons. Proc Natl Acad Sci U S A 109(47):19456-61. PubMed: 23129644 MGI: J:192261
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Fu C; Ess KC. 2013. Conditional and domain-specific inactivation of the Tsc2 gene in neural progenitor cells. Genesis 51(4):284-92. PubMed: 23359422 MGI: J:195049
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Galazo MJ; Emsley JG; Macklis JD. 2016. Corticothalamic Projection Neuron Development beyond Subtype Specification: Fog2 and Intersectional Controls Regulate Intraclass Neuronal Diversity. Neuron 91(1):90-106. PubMed: 27321927 MGI: J:239715
Garrett AM; Schreiner D; Lobas MA; Weiner JA. 2012. gamma-protocadherins control cortical dendrite arborization by regulating the activity of a FAK/PKC/MARCKS signaling pathway. Neuron 74(2):269-76. PubMed: 22542181 MGI: J:188387
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Genetic Resource Science at The Jackson Laboratory. 2008. Expression/Specificity Patterns of Cre Alleles Direct Data Submission from Genetic Resource Science :. MGI: J:137887
Genetic Resource Science at The Jackson Laboratory. 2012. Expression/Specificity Patterns of Cre Alleles, 2011 Direct Data Submission from Genetic Resource Science :. MGI: J:184578
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Gil-Sanz C; Landeira B; Ramos C; Costa MR; Muller U. 2014. Proliferative defects and formation of a double cortex in mice lacking Mltt4 and Cdh2 in the dorsal telencephalon. J Neurosci 34(32):10475-87. PubMed: 25100583 MGI: J:215584
Goffin D; Brodkin ES; Blendy JA; Siegel SJ; Zhou Z. 2014. Cellular origins of auditory event-related potential deficits in Rett syndrome. Nat Neurosci 17(6):804-6. PubMed: 24777420 MGI: J:212933
Golonzhka O; Nord A; Tang PL; Lindtner S; Ypsilanti AR; Ferretti E; Visel A; Selleri L; Rubenstein JL. 2015. Pbx Regulates Patterning of the Cerebral Cortex in Progenitors and Postmitotic Neurons. Neuron 88(6):1192-207. PubMed: 26671461 MGI: J:228726
Gong X; Zhang L; Huang T; Lin TV; Miyares L; Wen J; Hsieh L; Bordey A. 2015. Activating the translational repressor 4E-BP or reducing S6K-GSK3beta activity prevents accelerated axon growth induced by hyperactive mTOR in vivo. Hum Mol Genet 24(20):5746-58. PubMed: 26220974 MGI: J:226033
Gorski JA; Balogh SA; Wehner JM; Jones KR. 2003. Learning deficits in forebrain-restricted brain-derived neurotrophic factor mutant mice. Neuroscience 121(2):341-54. PubMed: 14521993 MGI: J:100000
Gorski JA; Zeiler SR; Tamowski S; Jones KR. 2003. Brain-derived neurotrophic factor is required for the maintenance of cortical dendrites. J Neurosci 23(17):6856-65. PubMed: 12890780 MGI: J:84683
Greer PL; Bear DM; Lassance JM; Bloom ML; Tsukahara T; Pashkovski SL; Masuda FK; Nowlan AC; Kirchner R; Hoekstra HE; Datta SR. 2016. A Family of non-GPCR Chemosensors Defines an Alternative Logic for Mammalian Olfaction. Cell 165(7):1734-48. PubMed: 27238024 MGI: J:234546
Grigaravicius P; Kaminska E; Hubner CA; McKinnon PJ; von Deimling A; Frappart PO. 2016. Rint1 inactivation triggers genomic instability, ER stress and autophagy inhibition in the brain. Cell Death Differ 23(3):454-68. PubMed: 26383973 MGI: J:239805
Griveau A; Borello U; Causeret F; Tissir F; Boggetto N; Karaz S; Pierani A. 2010. A novel role for Dbx1-derived Cajal-Retzius cells in early regionalization of the cerebral cortical neuroepithelium. PLoS Biol 8(7):e1000440. PubMed: 20668538 MGI: J:165303
Han Q; Cao C; Ding Y; So KF; Wu W; Qu Y; Zhou L. 2015. Plasticity of motor network and function in the absence of corticospinal projection. Exp Neurol 267:194-208. PubMed: 25792481 MGI: J:221606
Hantman AW; Jessell TM. 2010. Clarke's column neurons as the focus of a corticospinal corollary circuit. Nat Neurosci 13(10):1233-9. PubMed: 20835249 MGI: J:211843
Harb K; Magrinelli E; Nicolas CS; Lukianets N; Frangeul L; Pietri M; Sun T; Sandoz G; Grammont F; Jabaudon D; Studer M; Alfano C. 2016. Area-specific development of distinct projection neuron subclasses is regulated by postnatal epigenetic modifications. Elife 5:. PubMed: 26814051 MGI: J:230652
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Harrison SJ; Nishinakamura R; Jones KR; Monaghan AP. 2012. Sall1 regulates cortical neurogenesis and laminar fate specification in mice: implications for neural abnormalities in Townes-Brocks syndrome. Dis Model Mech 5(3):351-65. PubMed: 22228756 MGI: J:179804
Harwell CC; Parker PR; Gee SM; Okada A; McConnell SK; Kreitzer AC; Kriegstein AR. 2012. Sonic hedgehog expression in corticofugal projection neurons directs cortical microcircuit formation. Neuron 73(6):1116-26. PubMed: 22445340 MGI: J:183457
Hasenpusch-Theil K; Magnani D; Amaniti EM; Han L; Armstrong D; Theil T. 2012. Transcriptional analysis of Gli3 mutants identifies Wnt target genes in the developing hippocampus. Cereb Cortex 22(12):2878-93. PubMed: 22235033 MGI: J:203028
He H; Mahnke AH; Doyle S; Fan N; Wang CC; Hall BJ; Tang YP; Inglis FM; Chen C; Erickson JD. 2012. Neurodevelopmental role for VGLUT2 in pyramidal neuron plasticity, dendritic refinement, and in spatial learning. J Neurosci 32(45):15886-901. PubMed: 23136427 MGI: J:192240
Hippenmeyer S; Youn YH; Moon HM; Miyamichi K; Zong H; Wynshaw-Boris A; Luo L. 2010. Genetic mosaic dissection of lis1 and ndel1 in neuronal migration. Neuron 68(4):695-709. PubMed: 21092859 MGI: J:166047
Histed MH; Maunsell JH. 2014. Cortical neural populations can guide behavior by integrating inputs linearly, independent of synchrony. Proc Natl Acad Sci U S A 111(1):E178-87. PubMed: 24367105 MGI: J:206379
Houlihan SL; Lanctot AA; Guo Y; Feng Y. 2016. Upregulation of neurovascular communication through filamin abrogation promotes ectopic periventricular neurogenesis. Elife 5:. PubMed: 27664421 MGI: J:238096
Hu H; Li J; Gagen CS; Gray NW; Zhang Z; Qi Y; Zhang P. 2011. Conditional knockout of protein O-mannosyltransferase 2 reveals tissue-specific roles of O-mannosyl glycosylation in brain development. J Comp Neurol 519(7):1320-37. PubMed: 21452199 MGI: J:179356
Hu L; Lan W; Guo H; Chai GD; Huang K; Zhang L; Huang Y; Chen XF; Zhang L; Song NN; Chen L; Lang B; Wang Y; Wang QX; Zhang JB; McCaig C; Xu L; Ding YQ. 2014. A mouse line for inducible and reversible silencing of specific neurons. Mol Brain 7:68. PubMed: 25231486 MGI: J:232456
Hua ZL; Jeon S; Caterina MJ; Nathans J. 2014. Frizzled3 is required for the development of multiple axon tracts in the mouse central nervous system. Proc Natl Acad Sci U S A 111(29):E3005-14. PubMed: 24799694 MGI: J:212111
Huang J; Ikeuchi Y; Malumbres M; Bonni A. 2015. A Cdh1-APC/FMRP Ubiquitin Signaling Link Drives mGluR-Dependent Synaptic Plasticity in the Mammalian Brain. Neuron 86(3):726-39. PubMed: 25913861 MGI: J:221567
Huang L; Xian Q; Shen N; Shi L; Qu Y; Zhou L. 2015. Congenital absence of corticospinal tract does not severely affect plastic changes of the developing postnatal spinal cord. Neuroscience 301:338-50. PubMed: 26079333 MGI: J:224548
Huang WH; Guenthner CJ; Xu J; Nguyen T; Schwarz LA; Wilkinson AW; Gozani O; Chang HY; Shamloo M; Luo L. 2016. Molecular and Neural Functions of Rai1, the Causal Gene for Smith-Magenis Syndrome. Neuron 92(2):392-406. PubMed: 27693255 MGI: J:237687
Huang Z; Shimazu K; Woo NH; Zang K; Muller U; Lu B; Reichardt LF. 2006. Distinct roles of the beta 1-class integrins at the developing and the mature hippocampal excitatory synapse. J Neurosci 26(43):11208-19. PubMed: 17065460 MGI: J:114964
Hupe M; Li MX; Gertow Gillner K; Adams RH; Stenman JM. 2014. Evaluation of TRAP-sequencing technology with a versatile conditional mouse model. Nucleic Acids Res 42(2):e14. PubMed: 24165879 MGI: J:210222
Imayoshi I; Hirano K; Sakamoto M; Miyoshi G; Imura T; Kitano S; Miyachi H; Kageyama R. 2012. A multifunctional teal-fluorescent Rosa26 reporter mouse line for Cre- and Flp-mediated recombination. Neurosci Res 73(1):85-91. PubMed: 22343123 MGI: J:182745
Insolera R; Bazzi H; Shao W; Anderson KV; Shi SH. 2014. Cortical neurogenesis in the absence of centrioles. Nat Neurosci 17(11):1528-35. PubMed: 25282615 MGI: J:219422
Issa JB; Haeffele BD; Agarwal A; Bergles DE; Young ED; Yue DT. 2014. Multiscale optical Ca2+ imaging of tonal organization in mouse auditory cortex. Neuron 83(4):944-59. PubMed: 25088366 MGI: J:224581
Ivanova E; Hwang GS; Pan ZH. 2010. Characterization of transgenic mouse lines expressing Cre recombinase in the retina. Neuroscience 165(1):233-43. PubMed: 19837136 MGI: J:158209
Jaarsma D; van den Berg R; Wulf PS; van Erp S; Keijzer N; Schlager MA; de Graaff E; De Zeeuw CI; Pasterkamp RJ; Akhmanova A; Hoogenraad CC. 2014. A role for Bicaudal-D2 in radial cerebellar granule cell migration. Nat Commun 5:3411. PubMed: 24614806 MGI: J:210236
Jacobi A; Loy K; Schmalz AM; Hellsten M; Umemori H; Kerschensteiner M; Bareyre FM. 2015. FGF22 signaling regulates synapse formation during post-injury remodeling of the spinal cord. EMBO J 34(9):1231-43. PubMed: 25766255 MGI: J:221040
Jiang L; O'Leary C; Kim HA; Parish CL; Massalas J; Waddington JL; Ehrlich ME; Schutz G; Gantois I; Lawrence AJ; Drago J. 2015. Motor and behavioral phenotype in conditional mutants with targeted ablation of cortical D1 dopamine receptor-expressing cells. Neurobiol Dis 76:137-58. PubMed: 25684539 MGI: J:219868
Jiang X; Zhang M; You Y; Liu F. 2013. The production of somatostatin interneurons in the olfactory bulb is regulated by the transcription factor sp8. PLoS One 8(7):e70049. PubMed: 23894587 MGI: J:203184
Judson MC; Bergman MY; Campbell DB; Eagleson KL; Levitt P. 2009. Dynamic gene and protein expression patterns of the autism-associated met receptor tyrosine kinase in the developing mouse forebrain. J Comp Neurol 513(5):511-31. PubMed: 19226509 MGI: J:172491
Jung HJ; Coffinier C; Choe Y; Beigneux AP; Davies BS; Yang SH; Barnes RH 2nd; Hong J; Sun T; Pleasure SJ; Young SG; Fong LG. 2012. Regulation of prelamin A but not lamin C by miR-9, a brain-specific microRNA. Proc Natl Acad Sci U S A 109(7):E423-31. PubMed: 22308344 MGI: J:182630
Karalay O; Doberauer K; Vadodaria KC; Knobloch M; Berti L; Miquelajauregui A; Schwark M; Jagasia R; Taketo MM; Tarabykin V; Lie DC; Jessberger S. 2011. Prospero-related homeobox 1 gene (Prox1) is regulated by canonical Wnt signaling and has a stage-specific role in adult hippocampal neurogenesis. Proc Natl Acad Sci U S A 108(14):5807-12. PubMed: 21436036 MGI: J:171216
Kawase-Koga Y; Low R; Otaegi G; Pollock A; Deng H; Eisenhaber F; Maurer-Stroh S; Sun T. 2010. RNAase-III enzyme Dicer maintains signaling pathways for differentiation and survival in mouse cortical neural stem cells. J Cell Sci 123(Pt 4):586-94. PubMed: 20103535 MGI: J:158531
Kawase-Koga Y; Otaegi G; Sun T. 2009. Different timings of Dicer deletion affect neurogenesis and gliogenesis in the developing mouse central nervous system. Dev Dyn 238(11):2800-12. PubMed: 19806666 MGI: J:153666
Kim S; Lehtinen MK; Sessa A; Zappaterra MW; Cho SH; Gonzalez D; Boggan B; Austin CA; Wijnholds J; Gambello MJ; Malicki J; LaMantia AS; Broccoli V; Walsh CA. 2010. The apical complex couples cell fate and cell survival to cerebral cortical development. Neuron 66(1):69-84. PubMed: 20399730 MGI: J:160624
Kirmse K; Kummer M; Kovalchuk Y; Witte OW; Garaschuk O; Holthoff K. 2015. GABA depolarizes immature neurons and inhibits network activity in the neonatal neocortex in vivo. Nat Commun 6:7750. PubMed: 26177896 MGI: J:224458
Kohwi M; Petryniak MA; Long JE; Ekker M; Obata K; Yanagawa Y; Rubenstein JL; Alvarez-Buylla A. 2007. A subpopulation of olfactory bulb GABAergic interneurons is derived from Emx1- and Dlx5/6-expressing progenitors. J Neurosci 27(26):6878-91. PubMed: 17596436 MGI: J:160206
Kraushar ML; Thompson K; Wijeratne HR; Viljetic B; Sakers K; Marson JW; Kontoyiannis DL; Buyske S; Hart RP; Rasin MR. 2014. Temporally defined neocortical translation and polysome assembly are determined by the RNA-binding protein Hu antigen R. Proc Natl Acad Sci U S A 111(36):E3815-24. PubMed: 25157170 MGI: J:216392
Kraushar ML; Viljetic B; Wijeratne HR; Thompson K; Jiao X; Pike JW; Medvedeva V; Groszer M; Kiledjian M; Hart RP; Rasin MR. 2015. Thalamic WNT3 Secretion Spatiotemporally Regulates the Neocortical Ribosome Signature and mRNA Translation to Specify Neocortical Cell Subtypes. J Neurosci 35(31):10911-26. PubMed: 26245956 MGI: J:225880
Kroll TT; O'Leary DD. 2005. Ventralized dorsal telencephalic progenitors in Pax6 mutant mice generate GABA interneurons of a lateral ganglionic eminence fate. Proc Natl Acad Sci U S A 102(20):7374-9. PubMed: 15878992 MGI: J:99239
Kummer M; Kirmse K; Witte OW; Holthoff K. 2012. Reliable in vivo identification of both GABAergic and glutamatergic neurons using Emx1-Cre driven fluorescent reporter expression. Cell Calcium 52(2):182-9. PubMed: 22658827 MGI: J:231129
Kwon HJ; Ma S; Huang Z. 2011. Radial glia regulate Cajal-Retzius cell positioning in the early embryonic cerebral cortex. Dev Biol 351(1):25-34. PubMed: 21185282 MGI: J:170581
Lang C; Bradley PM; Jacobi A; Kerschensteiner M; Bareyre FM. 2013. STAT3 promotes corticospinal remodelling and functional recovery after spinal cord injury. EMBO Rep 14(10):931-7. PubMed: 23928811 MGI: J:203869
Lange C; Turrero Garcia M; Decimo I; Bifari F; Eelen G; Quaegebeur A; Boon R; Zhao H; Boeckx B; Chang J; Wu C; Le Noble F; Lambrechts D; Dewerchin M; Kuo CJ; Huttner WB; Carmeliet P. 2016. Relief of hypoxia by angiogenesis promotes neural stem cell differentiation by targeting glycolysis. EMBO J 35(9):924-41. PubMed: 26856890 MGI: J:231532
Lavado A; He Y; Pare J; Neale G; Olson EN; Giovannini M; Cao X. 2013. Tumor suppressor Nf2 limits expansion of the neural progenitor pool by inhibiting Yap/Taz transcriptional coactivators. Development 140(16):3323-34. PubMed: 23863479 MGI: J:199301
Lavado A; Ware M; Pare J; Cao X. 2014. The tumor suppressor Nf2 regulates corpus callosum development by inhibiting the transcriptional coactivator Yap. Development 141(21):4182-93. PubMed: 25336744 MGI: J:217604
Lee Y; Katyal S; Downing SM; Zhao J; Russell HR; McKinnon PJ. 2012. Neurogenesis requires TopBP1 to prevent catastrophic replicative DNA damage in early progenitors. Nat Neurosci 15(6):819-26. PubMed: 22522401 MGI: J:191367
Lee Y; Shull ER; Frappart PO; Katyal S; Enriquez-Rios V; Zhao J; Russell HR; Brown EJ; McKinnon PJ. 2012. ATR maintains select progenitors during nervous system development. EMBO J 31(5):1177-89. PubMed: 22266795 MGI: J:181920
Leone DP; Heavner WE; Ferenczi EA; Dobreva G; Huguenard JR; Grosschedl R; McConnell SK. 2015. Satb2 Regulates the Differentiation of Both Callosal and Subcerebral Projection Neurons in the Developing Cerebral Cortex. Cereb Cortex 25(10):3406-19. PubMed: 25037921 MGI: J:235635
Li G; Fang L; Fernandez G; Pleasure SJ. 2013. The ventral hippocampus is the embryonic origin for adult neural stem cells in the dentate gyrus. Neuron 78(4):658-72. PubMed: 23643936 MGI: J:201555
Li G; Kataoka H; Coughlin SR; Pleasure SJ. 2009. Identification of a transient subpial neurogenic zone in the developing dentate gyrus and its regulation by Cxcl12 and reelin signaling. Development 136(2):327-35. PubMed: 19103804 MGI: J:143512
Li HS; Wang D; Shen Q; Schonemann MD; Gorski JA; Jones KR; Temple S; Jan LY; Jan YN. 2003. Inactivation of Numb and Numblike in embryonic dorsal forebrain impairs neurogenesis and disrupts cortical morphogenesis. Neuron 40(6):1105-18. PubMed: 14687546 MGI: J:87149
Li J; Yu M; Feng G; Hu H; Li X. 2011. Breaches of the pial basement membrane are associated with defective dentate gyrus development in mouse models of congenital muscular dystrophies. Neurosci Lett 505(1):19-24. PubMed: 21970971 MGI: J:178536
Li Q; Bian S; Hong J; Kawase-Koga Y; Zhu E; Zheng Y; Yang L; Sun T. 2011. Timing specific requirement of microRNA function is essential for embryonic and postnatal hippocampal development. PLoS One 6(10):e26000. PubMed: 21991391 MGI: J:178118
Liang CC; Tanabe LM; Jou S; Chi F; Dauer WT. 2014. TorsinA hypofunction causes abnormal twisting movements and sensorimotor circuit neurodegeneration. J Clin Invest 124(7):3080-92. PubMed: 24937429 MGI: J:213785
Liang H; Hippenmeyer S; Ghashghaei HT. 2013. A Nestin-cre ttransgenic mouse is insufficient for recombination in early embryonic neural progenitors Biol Open 1(12):1200-1203. PubMed: 23259054 MGI: J:192871
Liang H; Xiao G; Yin H; Hippenmeyer S; Horowitz JM; Ghashghaei HT. 2013. Neural development is dependent on the function of specificity protein 2 in cell cycle progression. Development 140(3):552-61. PubMed: 23293287 MGI: J:194076
Livet J; Weissman TA; Kang H; Draft RW; Lu J; Bennis RA; Sanes JR; Lichtman JW. 2007. Transgenic strategies for combinatorial expression of fluorescent proteins in the nervous system. Nature 450(7166):56-62. PubMed: 17972876 MGI: J:125961
Lo FS; Erzurumlu RS; Powell EM. 2016. Insulin-Independent GABAA Receptor-Mediated Response in the Barrel Cortex of Mice with Impaired Met Activity. J Neurosci 36(13):3691-7. PubMed: 27030755 MGI: J:231751
Louvi A; Chen L; Two AM; Zhang H; Min W; Gunel M. 2011. Loss of cerebral cavernous malformation 3 (Ccm3) in neuroglia leads to CCM and vascular pathology. Proc Natl Acad Sci U S A 108(9):3737-42. PubMed: 21321212 MGI: J:170480
Louvi A; Nishimura S; Gunel M. 2014. Ccm3, a gene associated with cerebral cavernous malformations, is required for neuronal migration. Development 141(6):1404-15. PubMed: 24595293 MGI: J:208651
Lu HC; Tan Q; Rousseaux MW; Wang W; Kim JY; Richman R; Wan YW; Yeh SY; Patel JM; Liu X; Lin T; Lee Y; Fryer JD; Han J; Chahrour M; Finnell RH; Lei Y; Zurita-Jimenez ME; Ahimaz P; Anyane-Yeboa K; Van Maldergem L; Lehalle D; Jean-Marcais N; Mosca-Boidron AL; Thevenon J; Cousin MA; Bro DE; Lanpher BC; Klee EW; Alexander N; Bainbridge MN; Orr HT; Sillitoe RV; Ljungberg MC; Liu Z; Schaaf CP; Zoghbi HY. 2017. Disruption of the ATXN1-CIC complex causes a spectrum of neurobehavioral phenotypes in mice and humans. Nat Genet 49(4):527-536. PubMed: 28288114 MGI: J:240674
Ma S; Kwon HJ; Johng H; Zang K; Huang Z. 2013. Radial glial neural progenitors regulate nascent brain vascular network stabilization via inhibition of Wnt signaling. PLoS Biol 11(1):e1001469. PubMed: 23349620 MGI: J:194480
Madisen L; Mao T; Koch H; Zhuo JM; Berenyi A; Fujisawa S; Hsu YW; Garcia AJ 3rd; Gu X; Zanella S; Kidney J; Gu H; Mao Y; Hooks BM; Boyden ES; Buzsaki G; Ramirez JM; Jones AR; Svoboda K; Han X; Turner EE; Zeng H. 2012. A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing. Nat Neurosci 15(5):793-802. PubMed: 22446880 MGI: J:182204
Madisen L; Zwingman TA; Sunkin SM; Oh SW; Zariwala HA; Gu H; Ng LL; Palmiter RD; Hawrylycz MJ; Jones AR; Lein ES; Zeng H. 2010. A robust and high-throughput Cre reporting and characterization system for the whole mouse brain. Nat Neurosci 13(1):133-40. PubMed: 20023653 MGI: J:155793
Magnani D; Hasenpusch-Theil K; Theil T. 2013. Gli3 controls subplate formation and growth of cortical axons. Cereb Cortex 23(11):2542-51. PubMed: 22903314 MGI: J:215515
Magri L; Cambiaghi M; Cominelli M; Alfaro-Cervello C; Cursi M; Pala M; Bulfone A; Garcia-Verdugo JM; Leocani L; Minicucci F; Poliani PL; Galli R. 2011. Sustained Activation of mTOR Pathway in Embryonic Neural Stem Cells Leads to Development of Tuberous Sclerosis Complex-Associated Lesions. Cell Stem Cell 9(5):447-62. PubMed: 22056141 MGI: J:177840
Mandai K; Reimert DV; Ginty DD. 2014. Linx Mediates Interaxonal Interactions and Formation of the Internal Capsule. Neuron :. PubMed: 24930700 MGI: J:210221
Mao H; McMahon JJ; Tsai YH; Wang Z; Silver DL. 2016. Haploinsufficiency for Core Exon Junction Complex Components Disrupts Embryonic Neurogenesis and Causes p53-Mediated Microcephaly. PLoS Genet 12(9):e1006282. PubMed: 27618312 MGI: J:235650
Mao H; Pilaz LJ; McMahon JJ; Golzio C; Wu D; Shi L; Katsanis N; Silver DL. 2015. Rbm8a haploinsufficiency disrupts embryonic cortical development resulting in microcephaly. J Neurosci 35(18):7003-18. PubMed: 25948253 MGI: J:221648
Mardinly AR; Spiegel I; Patrizi A; Centofante E; Bazinet JE; Tzeng CP; Mandel-Brehm C; Harmin DA; Adesnik H; Fagiolini M; Greenberg ME. 2016. Sensory experience regulates cortical inhibition by inducing IGF1 in VIP neurons. Nature 531(7594):371-5. PubMed: 26958833 MGI: J:229663
McKenna WL; Ortiz-Londono CF; Mathew TK; Hoang K; Katzman S; Chen B. 2015. Mutual regulation between Satb2 and Fezf2 promotes subcerebral projection neuron identity in the developing cerebral cortex. Proc Natl Acad Sci U S A 112(37):11702-7. PubMed: 26324926 MGI: J:226916
McKinstry SU; Karadeniz YB; Worthington AK; Hayrapetyan VY; Ozlu MI; Serafin-Molina K; Risher WC; Ustunkaya T; Dragatsis I; Zeitlin S; Yin HH; Eroglu C. 2014. Huntingtin is required for normal excitatory synapse development in cortical and striatal circuits. J Neurosci 34(28):9455-72. PubMed: 25009276 MGI: J:215303
McMahon JJ; Shi L; Silver DL. 2014. Generation of a Magoh conditional allele in mice. Genesis 52(8):752-8. PubMed: 24771530 MGI: J:213515
Miquelajauregui A; Van de Putte T; Polyakov A; Nityanandam A; Boppana S; Seuntjens E; Karabinos A; Higashi Y; Huylebroeck D; Tarabykin V. 2007. Smad-interacting protein-1 (Zfhx1b) acts upstream of Wnt signaling in the mouse hippocampus and controls its formation. Proc Natl Acad Sci U S A 104(31):12919-24. PubMed: 17644613 MGI: J:123406
Molumby MJ; Keeler AB; Weiner JA. 2016. Homophilic Protocadherin Cell-Cell Interactions Promote Dendrite Complexity. Cell Rep 15(5):1037-50. PubMed: 27117416 MGI: J:235387
Moon UY; Park JY; Park R; Cho JY; Hughes LJ; McKenna J 3rd; Goetzl L; Cho SH; Crino PB; Gambello MJ; Kim S. 2015. Impaired Reelin-Dab1 Signaling Contributes to Neuronal Migration Deficits of Tuberous Sclerosis Complex. Cell Rep 12(6):965-78. PubMed: 26235615 MGI: J:232899
Nakajima M; Gorlich A; Heintz N. 2014. Oxytocin modulates female sociosexual behavior through a specific class of prefrontal cortical interneurons. Cell 159(2):295-305. PubMed: 25303526 MGI: J:217549
Niewmierzycka A; Mills J; St-Arnaud R; Dedhar S; Reichardt LF. 2005. Integrin-linked kinase deletion from mouse cortex results in cortical lamination defects resembling cobblestone lissencephaly. J Neurosci 25(30):7022-31. PubMed: 16049178 MGI: J:100025
Nityanandam A; Parthasarathy S; Tarabykin V. 2012. Postnatal subventricular zone of the neocortex contributes GFAP+ cells to the rostral migratory stream under the control of Sip1. Dev Biol 366(2):341-56. PubMed: 22546691 MGI: J:185418
Okerlund ND; Kivimae S; Tong CK; Peng IF; Ullian EM; Cheyette BN. 2010. Dact1 is a postsynaptic protein required for dendrite, spine, and excitatory synapse development in the mouse forebrain. J Neurosci 30(12):4362-8. PubMed: 20335472 MGI: J:159217
Orefice LL; Zimmerman AL; Chirila AM; Sleboda SJ; Head JP; Ginty DD. 2016. Peripheral Mechanosensory Neuron Dysfunction Underlies Tactile and Behavioral Deficits in Mouse Models of ASDs. Cell :. PubMed: 27293187 MGI: J:232023
Ortega-de San Luis C; Pascual A. 2016. Simultaneous Detection of Both GDNF and GFRalpha1 Expression Patterns in the Mouse Central Nervous System. Front Neuroanat 10:73. PubMed: 27445711 MGI: J:240355
Ozkan ED; Creson TK; Kramar EA; Rojas C; Seese RR; Babyan AH; Shi Y; Lucero R; Xu X; Noebels JL; Miller CA; Lynch G; Rumbaugh G. 2014. Reduced cognition in Syngap1 mutants is caused by isolated damage within developing forebrain excitatory neurons. Neuron 82(6):1317-33. PubMed: 24945774 MGI: J:215492
Paixao S; Balijepalli A; Serradj N; Niu J; Luo W; Martin JH; Klein R. 2013. EphrinB3/EphA4-mediated guidance of ascending and descending spinal tracts. Neuron 80(6):1407-20. PubMed: 24360544 MGI: J:207511
Park H; Popescu A; Poo MM. 2014. Essential role of presynaptic NMDA receptors in activity-dependent BDNF secretion and corticostriatal LTP. Neuron 84(5):1009-22. PubMed: 25467984 MGI: J:217528
Parthasarathy S; Srivatsa S; Nityanandam A; Tarabykin V. 2014. Ntf3 acts downstream of Sip1 in cortical postmitotic neurons to control progenitor cell fate through feedback signaling. Development 141(17):3324-30. PubMed: 25085976 MGI: J:214086
Pawlisz AS; Feng Y. 2011. Three-dimensional regulation of radial glial functions by Lis1-Nde1 and dystrophin glycoprotein complexes. PLoS Biol 9(10):e1001172. PubMed: 22028625 MGI: J:184033
Peng Y; Lu Z; Li G; Piechowicz M; Anderson M; Uddin Y; Wu J; Qiu S. 2016. The autism-associated MET receptor tyrosine kinase engages early neuronal growth mechanism and controls glutamatergic circuits development in the forebrain. Mol Psychiatry 21(7):925-35. PubMed: 26728565 MGI: J:233610
Pereira JD; Sansom SN; Smith J; Dobenecker MW; Tarakhovsky A; Livesey FJ. 2010. Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex. Proc Natl Acad Sci U S A 107(36):15957-62. PubMed: 20798045 MGI: J:164377
Peron SP; Freeman J; Iyer V; Guo C; Svoboda K. 2015. A Cellular Resolution Map of Barrel Cortex Activity during Tactile Behavior. Neuron 86(3):783-99. PubMed: 25913859 MGI: J:221246
Pilaz LJ; McMahon JJ; Miller EE; Lennox AL; Suzuki A; Salmon E; Silver DL. 2016. Prolonged Mitosis of Neural Progenitors Alters Cell Fate in the Developing Brain. Neuron 89(1):83-99. PubMed: 26748089 MGI: J:230878
Pinon MC; Tuoc TC; Ashery-Padan R; Molnar Z; Stoykova A. 2008. Altered molecular regionalization and normal thalamocortical connections in cortex-specific Pax6 knock-out mice. J Neurosci 28(35):8724-34. PubMed: 18753373 MGI: J:138792
Pollock A; Bian S; Zhang C; Chen Z; Sun T. 2014. Growth of the developing cerebral cortex is controlled by microRNA-7 through the p53 pathway. Cell Rep 7(4):1184-96. PubMed: 24813889 MGI: J:210596
Pucilowska J; Puzerey PA; Karlo JC; Galan RF; Landreth GE. 2012. Disrupted ERK Signaling during Cortical Development Leads to Abnormal Progenitor Proliferation, Neuronal and Network Excitability and Behavior, Modeling Human Neuro-Cardio-Facial-Cutaneous and Related Syndromes. J Neurosci 32(25):8663-77. PubMed: 22723706 MGI: J:185659
Qiu S; Anderson CT; Levitt P; Shepherd GM. 2011. Circuit-specific intracortical hyperconnectivity in mice with deletion of the autism-associated met receptor tyrosine kinase. J Neurosci 31(15):5855-64. PubMed: 21490227 MGI: J:170966
Qiu S; Lu Z; Levitt P. 2014. MET receptor tyrosine kinase controls dendritic complexity, spine morphogenesis, and glutamatergic synapse maturation in the hippocampus. J Neurosci 34(49):16166-79. PubMed: 25471559 MGI: J:218749
Qiu Z; Cang Y; Goff SP. 2010. Abl family tyrosine kinases are essential for basement membrane integrity and cortical lamination in the cerebellum. J Neurosci 30(43):14430-9. PubMed: 20980600 MGI: J:166211
Qu Y; Huang Y; Feng J; Alvarez-Bolado G; Grove EA; Yang Y; Tissir F; Zhou L; Goffinet AM. 2014. Genetic evidence that Celsr3 and Celsr2, together with Fzd3, regulate forebrain wiring in a Vangl-independent manner. Proc Natl Acad Sci U S A 111(29):E2996-3004. PubMed: 25002511 MGI: J:212261
Rasin MR; Gazula VR; Breunig JJ; Kwan KY; Johnson MB; Liu-Chen S; Li HS; Jan LY; Jan YN; Rakic P; Sestan N. 2007. Numb and Numbl are required for maintenance of cadherin-based adhesion and polarity of neural progenitors. Nat Neurosci 10(7):819-27. PubMed: 17589506 MGI: J:124218
Ravni A; Qu Y; Goffinet AM; Tissir F. 2009. Planar cell polarity cadherin Celsr1 regulates skin hair patterning in the mouse. J Invest Dermatol 129(10):2507-9. PubMed: 19357712 MGI: J:157059
Roberts JM; Ennajdaoui H; Edmondson C; Wirth B; Sanford JR; Chen B. 2014. Splicing factor TRA2B is required for neural progenitor survival. J Comp Neurol 522(2):372-92. PubMed: 23818142 MGI: J:206632
Ross SE; Mardinly AR; McCord AE; Zurawski J; Cohen S; Jung C; Hu L; Mok SI; Shah A; Savner EM; Tolias C; Corfas R; Chen S; Inquimbert P; Xu Y; McInnes RR; Rice FL; Corfas G; Ma Q; Woolf CJ; Greenberg ME. 2010. Loss of inhibitory interneurons in the dorsal spinal cord and elevated itch in Bhlhb5 mutant mice. Neuron 65(6):886-98. PubMed: 20346763 MGI: J:158273
Ross SE; McCord AE; Jung C; Atan D; Mok SI; Hemberg M; Kim TK; Salogiannis J; Hu L; Cohen S; Lin Y; Harrar D; McInnes RR; Greenberg ME. 2012. Bhlhb5 and Prdm8 form a repressor complex involved in neuronal circuit assembly. Neuron 73(2):292-303. PubMed: 22284184 MGI: J:182304
Rothermel M; Brunert D; Zabawa C; Diaz-Quesada M; Wachowiak M. 2013. Transgene expression in target-defined neuron populations mediated by retrograde infection with adeno-associated viral vectors. J Neurosci 33(38):15195-206. PubMed: 24048849 MGI: J:231995
Saurat N; Andersson T; Vasistha NA; Molnar Z; Livesey FJ. 2013. Dicer is required for neural stem cell multipotency and lineage progression during cerebral cortex development. Neural Dev 8:14. PubMed: 23895693 MGI: J:199787
Schmidt EF; Warner-Schmidt JL; Otopalik BG; Pickett SB; Greengard P; Heintz N. 2012. Identification of the cortical neurons that mediate antidepressant responses. Cell 149(5):1152-63. PubMed: 22632977 MGI: J:226971
Serradj N; Paixao S; Sobocki T; Feinberg M; Klein R; Kullander K; Martin JH. 2014. EphA4-Mediated Ipsilateral Corticospinal Tract Misprojections Are Necessary for Bilateral Voluntary Movements But Not Bilateral Stereotypic Locomotion. J Neurosci 34(15):5211-21. PubMed: 24719100 MGI: J:208113
Seuntjens E; Nityanandam A; Miquelajauregui A; Debruyn J; Stryjewska A; Goebbels S; Nave KA; Huylebroeck D; Tarabykin V. 2009. Sip1 regulates sequential fate decisions by feedback signaling from postmitotic neurons to progenitors. Nat Neurosci 12(11):1373-80. PubMed: 19838179 MGI: J:154601
Shanks JA; Ito S; Schaevitz L; Yamada J; Chen B; Litke A; Feldheim DA. 2016. Corticothalamic Axons Are Essential for Retinal Ganglion Cell Axon Targeting to the Mouse Dorsal Lateral Geniculate Nucleus. J Neurosci 36(19):5252-63. PubMed: 27170123 MGI: J:231954
Shetty AS; Godbole G; Maheshwari U; Padmanabhan H; Chaudhary R; Muralidharan B; Hou PS; Monuki ES; Kuo HC; Rema V; Tole S. 2013. Lhx2 regulates a cortex-specific mechanism for barrel formation. Proc Natl Acad Sci U S A 110(50):E4913-21. PubMed: 24262147 MGI: J:205196
Shimada M; Dumitrache LC; Russell HR; McKinnon PJ. 2015. Polynucleotide kinase-phosphatase enables neurogenesis via multiple DNA repair pathways to maintain genome stability. EMBO J 34(19):2465-80. PubMed: 26290337 MGI: J:226703
Shrestha P; Mousa A; Heintz N. 2015. Layer 2/3 pyramidal cells in the medial prefrontal cortex moderate stress induced depressive behaviors. Elife 4:. PubMed: 26371510 MGI: J:226995
Simon R; Brylka H; Schwegler H; Venkataramanappa S; Andratschke J; Wiegreffe C; Liu P; Fuchs E; Jenkins NA; Copeland NG; Birchmeier C; Britsch S. 2012. A dual function of Bcl11b/Ctip2 in hippocampal neurogenesis. EMBO J 31(13):2922-36. PubMed: 22588081 MGI: J:187013
Soh H; Pant R; Loturco JJ; Tzingounis AV. 2014. Conditional Deletions of Epilepsy-Associated KCNQ2 and KCNQ3 Channels from Cerebral Cortex Cause Differential Effects on Neuronal Excitability. J Neurosci 34(15):5311-21. PubMed: 24719109 MGI: J:208109
Spiegel I; Mardinly AR; Gabel HW; Bazinet JE; Couch CH; Tzeng CP; Harmin DA; Greenberg ME. 2014. Npas4 regulates excitatory-inhibitory balance within neural circuits through cell-type-specific gene programs. Cell 157(5):1216-29. PubMed: 24855953 MGI: J:214381
Sreenivasan V; Karmakar K; Rijli FM; Petersen CC. 2015. Parallel pathways from motor and somatosensory cortex for controlling whisker movements in mice. Eur J Neurosci 41(3):354-67. PubMed: 25476605 MGI: J:238179
Strand AD; Baquet ZC; Aragaki AK; Holmans P; Yang L; Cleren C; Beal MF; Jones L; Kooperberg C; Olson JM; Jones KR. 2007. Expression profiling of Huntington's disease models suggests that brain-derived neurotrophic factor depletion plays a major role in striatal degeneration. J Neurosci 27(43):11758-68. PubMed: 17959817 MGI: J:127037
Svoboda DS; Paquin A; Park DS; Slack RS. 2013. Pocket proteins pRb and p107 are required for cortical lamination independent of apoptosis. Dev Biol 384(1):101-13. PubMed: 24056077 MGI: J:203999
Switon K; Kotulska K; Janusz-Kaminska A; Zmorzynska J; Jaworski J. 2017. Molecular neurobiology of mTOR. Neuroscience 341:112-153. PubMed: 27889578 MGI: J:238268
Tarkar A; Loges NT; Slagle CE; Francis R; Dougherty GW; Tamayo JV; Shook B; Cantino M; Schwartz D; Jahnke C; Olbrich H; Werner C; Raidt J; Pennekamp P; Abouhamed M; Hjeij R; Kohler G; Griese M; Li Y; Lemke K; Klena N; Liu X; Gabriel G; Tobita K; Jaspers M; Morgan LC; Shapiro AJ; Letteboer SJ; Mans DA; Carson JL; Leigh MW; Wolf WE; Chen S; Lucas JS; Onoufriadis A; Plagnol V; Schmidts M; Boldt K; Roepman R; Zariwala MA; Lo CW; Mitchison HM; Knowles MR; Burdine RD; Loturco JJ; Omran H. 2013. DYX1C1 is required for axonemal dynein assembly and ciliary motility. Nat Genet 45(9):995-1003. PubMed: 23872636 MGI: J:205312
Taylor AS; Glascock JJ; Rose FF Jr; Lutz C; Lorson CL. 2013. Restoration of SMN to Emx-1 expressing cortical neurons is not sufficient to provide benefit to a severe mouse model of Spinal Muscular Atrophy. Transgenic Res 22(5):1029-36. PubMed: 23512182 MGI: J:213313
Tissir F; Qu Y; Montcouquiol M; Zhou L; Komatsu K; Shi D; Fujimori T; Labeau J; Tyteca D; Courtoy P; Poumay Y; Uemura T; Goffinet AM. 2010. Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus. Nat Neurosci 13(6):700-7. PubMed: 20473291 MGI: J:161641
Tuoc TC; Boretius S; Sansom SN; Pitulescu ME; Frahm J; Livesey FJ; Stoykova A. 2013. Chromatin Regulation by BAF170 Controls Cerebral Cortical Size and Thickness. Dev Cell 25(3):256-69. PubMed: 23643363 MGI: J:197141
Tuoc TC; Radyushkin K; Tonchev AB; Pinon MC; Ashery-Padan R; Molnar Z; Davidoff MS; Stoykova A. 2009. Selective cortical layering abnormalities and behavioral deficits in cortex-specific Pax6 knock-out mice. J Neurosci 29(26):8335-49. PubMed: 19571125 MGI: J:150808
Waclaw RR; Wang B; Pei Z; Ehrman LA; Campbell K. 2009. Distinct temporal requirements for the homeobox gene Gsx2 in specifying striatal and olfactory bulb neuronal fates. Neuron 63(4):451-65. PubMed: 19709628 MGI: J:154936
Wagnon JL; Mahaffey CL; Sun W; Yang Y; Chao HT; Frankel WN. 2011. Etiology of a genetically complex seizure disorder in Celf4 mutant mice. Genes Brain Behav 10(7):765-77. PubMed: 21745337 MGI: J:181678
Wang H; Warner-Schmidt J; Varela S; Enikolopov G; Greengard P; Flajolet M. 2015. Norbin ablation results in defective adult hippocampal neurogenesis and depressive-like behavior in mice. Proc Natl Acad Sci U S A 112(31):9745-50. PubMed: 26195764 MGI: J:226063
Wang PS; Chou FS; Ramachandran S; Xia S; Chen HY; Guo F; Suraneni P; Maher BJ; Li R. 2016. Crucial roles of the Arp2/3 complex during mammalian corticogenesis. Development 143(15):2741-52. PubMed: 27385014 MGI: J:235720
Wang Y; Wu Q; Yang P; Wang C; Liu J; Ding W; Liu W; Bai Y; Yang Y; Wang H; Gao S; Wang X. 2016. LSD1 co-repressor Rcor2 orchestrates neurogenesis in the developing mouse brain. Nat Commun 7:10481. PubMed: 26795843 MGI: J:235702
Wei B; Huang Z; He S; Sun C; You Y; Liu F; Yang Z. 2012. The onion skin-like organization of the septum arises from multiple embryonic origins to form multiple adult neuronal fates. Neuroscience 222:110-23. PubMed: 22820053 MGI: J:192502
Wei B; Nie Y; Li X; Wang C; Ma T; Huang Z; Tian M; Sun C; Cai Y; You Y; Liu F; Yang Z. 2011. Emx1-expressing neural stem cells in the subventricular zone give rise to new interneurons in the ischemic injured striatum. Eur J Neurosci 33(5):819-30. PubMed: 21219481 MGI: J:176857
Whelan G; Kreidl E; Wutz G; Egner A; Peters JM; Eichele G. 2012. Cohesin acetyltransferase Esco2 is a cell viability factor and is required for cohesion in pericentric heterochromatin. EMBO J 31(1):71-82. PubMed: 22101327 MGI: J:180371
Wiegreffe C; Simon R; Peschkes K; Kling C; Strehle M; Cheng J; Srivatsa S; Liu P; Jenkins NA; Copeland NG; Tarabykin V; Britsch S. 2015. Bcl11a (Ctip1) Controls Migration of Cortical Projection Neurons through Regulation of Sema3c. Neuron 87(2):311-25. PubMed: 26182416 MGI: J:227426
Willaime-Morawek S; Seaberg RM; Batista C; Labbe E; Attisano L; Gorski JA; Jones KR; Kam A; Morshead CM; van der Kooy D. 2006. Embryonic cortical neural stem cells migrate ventrally and persist as postnatal striatal stem cells. J Cell Biol 175(1):159-68. PubMed: 17030986 MGI: J:114513
Willenberg R; Steward O. 2015. Nonspecific labeling limits the utility of Cre-Lox bred CST-YFP mice for studies of corticospinal tract regeneration. J Comp Neurol 523(18):2665-82. PubMed: 25976033 MGI: J:227738
Woodworth MB; Greig LC; Liu KX; Ippolito GC; Tucker HO; Macklis JD. 2016. Ctip1 Regulates the Balance between Specification of Distinct Projection Neuron Subtypes in Deep Cortical Layers. Cell Rep 15(5):999-1012. PubMed: 27117402 MGI: J:235394
Wu X; Gu X; Han X; Du A; Jiang Y; Zhang X; Wang Y; Cao G; Zhao C. 2014. A novel function for Foxm1 in interkinetic nuclear migration in the developing telencephalon and anxiety-related behavior. J Neurosci 34(4):1510-22. PubMed: 24453338 MGI: J:206964
Xie Y; Juschke C; Esk C; Hirotsune S; Knoblich JA. 2013. The phosphatase PP4c controls spindle orientation to maintain proliferative symmetric divisions in the developing neocortex. Neuron 79(2):254-65. PubMed: 23830831 MGI: J:201674
Xing L; Larsen RS; Bjorklund GR; Li X; Wu Y; Philpot BD; Snider WD; Newbern JM. 2016. Layer specific and general requirements for ERK/MAPK signaling in the developing neocortex. Elife 5:. PubMed: 26848828 MGI: J:230714
Xu HT; Han Z; Gao P; He S; Li Z; Shi W; Kodish O; Shao W; Brown KN; Huang K; Shi SH. 2014. Distinct lineage-dependent structural and functional organization of the hippocampus. Cell 157(7):1552-64. PubMed: 24949968 MGI: J:214530
Yamamoto H; Mandai K; Konno D; Maruo T; Matsuzaki F; Takai Y. 2015. Impairment of radial glial scaffold-dependent neuronal migration and formation of double cortex by genetic ablation of afadin. Brain Res 1620:139-52. PubMed: 25988834 MGI: J:229121
Yan K; Rousseau J; Littlejohn RO; Kiss C; Lehman A; Rosenfeld JA; Stumpel CT; Stegmann AP; Robak L; Scaglia F; Nguyen TT; Fu H; Ajeawung NF; Camurri MV; Li L; Gardham A; Panis B; Almannai M; Sacoto MJ; Baskin B; Ruivenkamp C; Xia F; Bi W; Cho MT; Potjer TP; Santen GW; Parker MJ; Canham N; McKinnon M; Potocki L; MacKenzie JJ; Roeder ER; Campeau PM; Yang XJ. 2017. Mutations in the Chromatin Regulator Gene BRPF1 Cause Syndromic Intellectual Disability and Deficient Histone Acetylation. Am J Hum Genet 100(1):91-104. PubMed: 27939640 MGI: J:240552
Yang YJ; Baltus AE; Mathew RS; Murphy EA; Evrony GD; Gonzalez DM; Wang EP; Marshall-Walker CA; Barry BJ; Murn J; Tatarakis A; Mahajan MA; Samuels HH; Shi Y; Golden JA; Mahajnah M; Shenhav R; Walsh CA. 2012. Microcephaly gene links trithorax and REST/NRSF to control neural stem cell proliferation and differentiation. Cell 151(5):1097-112. PubMed: 23178126 MGI: J:193339
Yoshida M; Assimacopoulos S; Jones KR; Grove EA. 2006. Massive loss of Cajal-Retzius cells does not disrupt neocortical layer order. Development 133(3):537-45. PubMed: 16410414 MGI: J:104373
You L; Yan K; Zhou J; Zhao H; Bertos NR; Park M; Wang E; Yang XJ. 2015. The lysine acetyltransferase activator Brpf1 governs dentate gyrus development through neural stem cells and progenitors. PLoS Genet 11(3):e1005034. PubMed: 25757017 MGI: J:224155
You L; Zou J; Zhao H; Bertos NR; Park M; Wang E; Yang XJ. 2015. Deficiency of the chromatin regulator BRPF1 causes abnormal brain development. J Biol Chem 290(11):7114-29. PubMed: 25568313 MGI: J:241490
Zariwala HA; Borghuis BG; Hoogland TM; Madisen L; Tian L; De Zeeuw CI; Zeng H; Looger LL; Svoboda K; Chen TW. 2012. A Cre-dependent GCaMP3 reporter mouse for neuronal imaging in vivo. J Neurosci 32(9):3131-41. PubMed: 22378886 MGI: J:182205
Zembrzycki A; Chou SJ; Ashery-Padan R; Stoykova A; O'Leary DD. 2013. Sensory cortex limits cortical maps and drives top-down plasticity in thalamocortical circuits. Nat Neurosci 16(8):1060-7. PubMed: 23831966 MGI: J:203728
Zhang L; Bartley CM; Gong X; Hsieh LS; Lin TV; Feliciano DM; Bordey A. 2014. MEK-ERK1/2-dependent FLNA overexpression promotes abnormal dendritic patterning in tuberous sclerosis independent of mTOR. Neuron 84(1):78-91. PubMed: 25277454 MGI: J:218036
Zhang W; Peterson M; Beyer B; Frankel WN; Zhang ZW. 2014. Loss of MeCP2 from forebrain excitatory neurons leads to cortical hyperexcitation and seizures. J Neurosci 34(7):2754-63. PubMed: 24523563 MGI: J:206934
Zhou L; Bar I; Achouri Y; Campbell K; De Backer O; Hebert JM; Jones K; Kessaris N; de Rouvroit CL; O'Leary D; Richardson WD; Goffinet AM; Tissir F. 2008. Early forebrain wiring: genetic dissection using conditional Celsr3 mutant mice. Science 320(5878):946-9. PubMed: 18487195 MGI: J:134879
Zhou X; Liu F; Tian M; Xu Z; Liang Q; Wang C; Li J; Liu Z; Tang K; He M; Yang Z. 2015. Transcription factors COUP-TFI and COUP-TFII are required for the production of granule cells in the mouse olfactory bulb. Development 142(9):1593-605. PubMed: 25922524 MGI: J:239278
Zhu H; Aryal DK; Olsen RH; Urban DJ; Swearingen A; Forbes S; Roth BL; Hochgeschwender U. 2016. Cre-dependent DREADD (Designer Receptors Exclusively Activated by Designer Drugs) mice. Genesis 54(8):439-46. PubMed: 27194399 MGI: J:236327

Also Known As: Emx1IRES cre

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Emx1tm1(cre)Krj

Allele Symbol: Emx1tm1(cre)Krj

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Genotype: cre related

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Genotype: Emx1tm1(cre)Krj/Emx1tm1(cre)Krjinvolves: 129S2/SvPas * C57BL/6

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Also Known As: Emx1^{IRES cre}

Emx1^tm1(cre)Krj

Allele Symbol: Emx1^tm1(cre)Krj

Genotype: Emx1^tm1(cre)Krj/Emx1^tm1(cre)Krj
involves: 129S2/SvPas * C57BL/6

Additional - Emx1^tm1(cre)Krj related