JAX
Mouse Strain Datasheet - 005628
B6.129S2-Emx1tm1(cre)Krj/J
Also Known As: Emx1IRES cre
Emx1-IRES-Cre knockin mice have the endogenous Emx1 locus directing expression of Cre recombinase to approximately 88% of the neurons of the neocortex and hippocampus, and in the glial cells of the pallium. These mice are useful in studies of forebrain development and function.
Donating Investigator
Kevin R. Jones, University of Colorado- Boulder
Genetic overview
| Genetic Background | Generation |
|---|---|
|
N12+N1F12
|
Emx1tm1(cre)Krj
| Allele Type | Gene Symbol | Gene Name |
|---|---|---|
| Targeted (Recombinase-expressing) | Emx1 | empty spiracles homeobox 1 |
Detailed Description
Mice homozygous for the targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. This strain expresses Cre recombinase from the endogenous Emx1 locus. Western blot analysis of cortical brain tissue does not detect reduced endogenous gene product (protein). When crossed with a strain containing a loxP-site flanked sequence, Cre-mediated recombination results in tissue-specific deletion of the flanked sequence. Recombination occurs in approximately 88% of the neurons of the neocortex and hippocampus, and in the glial cells of the pallium, mimicking the pattern of expression of the endogenous gene. Further, the donating investigator reports that Cre recombinase is also expressed in a subset of male germline cells, thus some offspring from a cre; floxed male will have the floxed allele recombined in all cells. Our findings suggest that females may also be similarly affected. This mutant mouse strain represents a model that may be useful in studies of forebrain development and function.
View cre expression characterization.
Development
A targeting vector containing an internal ribosome entry site (IRES) sequence, Cre coding sequence, a polyadenlyation signal and a FRT site flanked PGK-neomycin cassette was inserted 120bp 3' from the stop codon, in the 3' untranslated region. The construct was electroporated into 129S2/SvPas derived D3 embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient blastocysts. The resulting chimeric animal was crossed to a Flp recombinase expressing strain (FLP-4917) to remove the selection cassette. The mice were then backcrossed to C57BL/6 mice for 12 generations.
Expression Data
| Expressed Gene | cre, cre recombinase, bacteriophage P1 |
|---|---|
| Site of Expression | neurons of the neocortex and hippocampus; some germline |
Control Suggestions
Selected References
- Gorski JA; Talley T; Qiu M; Puelles L; Rubenstein JL; Jones KR. 2002. Cortical excitatory neurons and glia, but not GABAergic neurons, are produced in the Emx1-expressing lineage.. In: . . MGI: J:78098
Emx1tm1(cre)Krj
Allele Symbol: Emx1tm1(cre)Krj
| Allele Name | targeted mutation 1, Kevin R Jones |
|---|---|
| Allele Type | Targeted (Recombinase-expressing) |
| Allele Synonym(s) | Emx1-IRES-Cre; Emx1Cre; Emx1IREScre; emx1-cre |
| Gene Symbol and Name | Emx1, empty spiracles homeobox 1 |
| Gene Synonym(s) | RGD1564002 |
| Expressed Gene | cre, cre recombinase, bacteriophage P1 |
| Site of Expression | neurons of the neocortex and hippocampus; some germline |
| Strain of Origin | 129S2/SvPas |
| Chromosome | 6 |
| Molecular Note | An IRES-cre gene followed by an FRT flanked PGK-neomycin gene was inserted 120 bp 3' of the stop codon. The neomycin gene was later removed in vivo by crossing to an Flp recombinase expressing transgenic strain. The protein product of this gene was produced in normal quantities as confirmed by Western blot analysis. Cre recombinase expression was characterized by crossing to a Rosa26 strain. |
| Mutations Made By | Kevin Jones, University of Colorado- Boulder |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Neurobiology Research
- Cre-lox System
- Cre Recombinase expression in neural tissue
- Neurodevelopmental Defects
- Cre-lox System
- Research Tools
- Cre-lox System
- Cre Recombinase Expression
- Cre Recombinase Expression: Germline/Embryonic Expression
- Developmental Biology Research
- Cre-lox System
- Neurobiology Research
- Cre-lox System
Genotype: cre related
- Research Tools
- Cre-lox System
- Genetics Research
- Mutagenesis and Transgenesis
- Mutagenesis and Transgenesis: Cre-lox System
Mammalian Phenotype Terms by Genotype
The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain
Genotype: Emx1tm1(cre)Krj/Emx1tm1(cre)Krj
involves: 129S2/SvPas * C57BL/6
normal phenotype
- no abnormal phenotype detected
- homozygous mice do not show any of the abnormal phenotypes shown for Emx1tm1Jlr homozygotes (MGI Ref ID J:78098)
References
- Gorski JA; Talley T; Qiu M; Puelles L; Rubenstein JL; Jones KR. 2002. Cortical excitatory neurons and glia, but not GABAergic neurons, are produced in the Emx1-expressing lineage.. In: . . MGI: J:78098
Additional - Emx1tm1(cre)Krj related
- Abraira VE; Kuehn ED; Chirila AM; Springel MW; Toliver AA; Zimmerman AL; Orefice LL; Boyle KA; Bai L; Song BJ; Bashista KA; O'Neill TG; Zhuo J; Tsan C; Hoynoski J; Rutlin M; Kus L; Niederkofler V; Watanabe M; Dymecki SM; Nelson SB; Heintz N; Hughes DI; Ginty DD. 2017. The Cellular and Synaptic Architecture of the Mechanosensory Dorsal Horn.. In: . . MGI: J:239228
- Ahmari SE; Spellman T; Douglass NL; Kheirbek MA; Simpson HB; Deisseroth K; Gordon JA; Hen R. 2013. Repeated cortico-striatal stimulation generates persistent OCD-like behavior.. In: . . MGI: J:199177
- Alfano C; Viola L; Heng JI; Pirozzi M; Clarkson M; Flore G; De Maio A; Schedl A; Guillemot F; Studer M. 2011. COUP-TFI promotes radial migration and proper morphology of callosal projection neurons by repressing Rnd2 expression.. In: . . MGI: J:178862
- Altmuller F; Pothula S; Annamneedi A; Nakhaei-Rad S; Montenegro-Venegas C; Pina-Fernandez E; Marini C; Santos M; Schanze D; Montag D; Ahmadian MR; Stork O; Zenker M; Fejtova A. 2017. Aberrant neuronal activity-induced signaling and gene expression in a mouse model of RASopathy.. In: . . MGI: J:242312
- Amaniti EM; Fu C; Lewis S; Saisana M; Magnani D; Mason JO; Theil T. 2015. Expansion of the piriform cortex contributes to corticothalamic pathfinding defects in Gli3 conditional mutants.. In: . . MGI: J:229226
- Amaniti EM; Hasenpusch-Theil K; Li Z; Magnani D; Kessaris N; Mason JO; Theil T. 2013. Gli3 is required in Emx1(+) progenitors for the development of the corpus callosum.. In: . . MGI: J:195145
- Antoine MW; Hubner CA; Arezzo JC; Hebert JM. 2013. A causative link between inner ear defects and long-term striatal dysfunction.. In: . . MGI: J:201156
- Armentano M; Chou SJ; Tomassy GS; Leingartner A; O'Leary DD; Studer M. 2007. COUP-TFI regulates the balance of cortical patterning between frontal/motor and sensory areas.. In: . . MGI: J:127387
- Armour EA; Carson RP; Ess KC. 2012. Cystogenesis and elongated primary cilia in Tsc1-deficient distal convoluted tubules.. In: . . MGI: J:188431
- Asinof SK; Sukoff Rizzo SJ; Buckley AR; Beyer BJ; Letts VA; Frankel WN; Boumil RM. 2015. Independent Neuronal Origin of Seizures and Behavioral Comorbidities in an Animal Model of a Severe Childhood Genetic Epileptic Encephalopathy.. In: . . MGI: J:224850
- Ballester-Rosado CJ; Albright MJ; Wu CS; Liao CC; Zhu J; Xu J; Lee LJ; Lu HC. 2010. mGluR5 in cortical excitatory neurons exerts both cell-autonomous and -nonautonomous influences on cortical somatosensory circuit formation.. In: . . MGI: J:167595
- Baquet ZC; Gorski JA; Jones KR. 2004. Early striatal dendrite deficits followed by neuron loss with advanced age in the absence of anterograde cortical brain-derived neurotrophic factor.. In: . . MGI: J:96903
- Bareyre FM; Kerschensteiner M; Misgeld T; Sanes JR. 2005. Transgenic labeling of the corticospinal tract for monitoring axonal responses to spinal cord injury.. In: . . MGI: J:123607
- Barnes AP; Lilley BN; Pan YA; Plummer LJ; Powell AW; Raines AN; Sanes JR; Polleux F. 2007. LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons.. In: . . MGI: J:162066
- Barros CS; Calabrese B; Chamero P; Roberts AJ; Korzus E; Lloyd K; Stowers L; Mayford M; Halpain S; Muller U. 2009. Impaired maturation of dendritic spines without disorganization of cortical cell layers in mice lacking NRG1/ErbB signaling in the central nervous system.. In: . . MGI: J:146779
- Beggs HE; Schahin-Reed D; Zang K; Goebbels S; Nave KA; Gorski J; Jones KR; Sretavan D; Reichardt LF. 2003. FAK deficiency in cells contributing to the basal lamina results in cortical abnormalities resembling congenital muscular dystrophies.. In: . . MGI: J:86453
- Benadiba C; Magnani D; Niquille M; Morle L; Valloton D; Nawabi H; Ait-Lounis A; Otsmane B; Reith W; Theil T; Hornung JP; Lebrand C; Durand B. 2012. The ciliogenic transcription factor RFX3 regulates early midline distribution of guidepost neurons required for corpus callosum development.. In: . . MGI: J:183848
- Berger J; Berger S; Tuoc TC; D'Amelio M; Cecconi F; Gorski JA; Jones KR; Gruss P; Stoykova A. 2007. Conditional activation of Pax6 in the developing cortex of transgenic mice causes progenitor apoptosis.. In: . . MGI: J:135032
- Betley JN; Wright CV; Kawaguchi Y; Erdelyi F; Szabo G; Jessell TM; Kaltschmidt JA. 2009. Stringent specificity in the construction of a GABAergic presynaptic inhibitory circuit.. In: . . MGI: J:157313
- Bloodgood BL; Sharma N; Browne HA; Trepman AZ; Greenberg ME. 2013. The activity-dependent transcription factor NPAS4 regulates domain-specific inhibition.. In: . . MGI: J:207770
- Bloom AJ; Miller BR; Sanes JR; Diantonio A. 2007. The requirement for Phr1 in CNS axon tract formation reveals the corticostriatal boundary as a choice point for cortical axons.. In: . . MGI: J:125702
- Borello U; Madhavan M; Vilinsky I; Faedo A; Pierani A; Rubenstein J; Campbell K. 2014. Sp8 and COUP-TF1 reciprocally regulate patterning and Fgf signaling in cortical progenitors.. In: . . MGI: J:222465
- Boretius S; Michaelis T; Tammer R; Ashery-Padan R; Frahm J; Stoykova A. 2009. In vivo MRI of altered brain anatomy and fiber connectivity in adult pax6 deficient mice.. In: . . MGI: J:174170
- Borgius L; Nishimaru H; Caldeira V; Kunugise Y; Low P; Reig R; Itohara S; Iwasato T; Kiehn O. 2014. Spinal glutamatergic neurons defined by EphA4 signaling are essential components of normal locomotor circuits.. In: . . MGI: J:209606
- Bosch PJ; Fuller LC; Sleeth CM; Weiner JA. 2016. Akirin2 is essential for the formation of the cerebral cortex.. In: . . MGI: J:237195
- Brinkmann BG; Agarwal A; Sereda MW; Garratt AN; Muller T; Wende H; Stassart RM; Nawaz S; Humml C; Velanac V; Radyushkin K; Goebbels S; Fischer TM; Franklin RJ; Lai C; Ehrenreich H; Birchmeier C; Schwab MH; Nave KA. 2008. Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system.. In: . . MGI: J:145464
- Brown KN; Chen S; Han Z; Lu CH; Tan X; Zhang XJ; Ding L; Lopez-Cruz A; Saur D; Anderson SA; Huang K; Shi SH. 2011. Clonal production and organization of inhibitory interneurons in the neocortex.. In: . . MGI: J:177854
- Caronia G; Wilcoxon J; Feldman P; Grove EA. 2010. Bone morphogenetic protein signaling in the developing telencephalon controls formation of the hippocampal dentate gyrus and modifies fear-related behavior.. In: . . MGI: J:160559
- Caronia-Brown G; Grove EA. 2011. Timing of cortical interneuron migration is influenced by the cortical hem.. In: . . MGI: J:181828
- Carson RP; Fu C; Winzenburger P; Ess KC. 2013. Deletion of Rictor in neural progenitor cells reveals contributions of mTORC2 signaling to tuberous sclerosis complex.. In: . . MGI: J:191137
- Carson RP; Van Nielen DL; Winzenburger PA; Ess KC. 2012. Neuronal and glia abnormalities in Tsc1-deficient forebrain and partial rescue by rapamycin.. In: . . MGI: J:179842
- Cederquist GY; Azim E; Shnider SJ; Padmanabhan H; Macklis JD. 2013. Lmo4 establishes rostral motor cortex projection neuron subtype diversity.. In: . . MGI: J:196674
- Chang H; Smallwood PM; Williams J; Nathans J. 2016. The spatio-temporal domains of Frizzled6 action in planar polarity control of hair follicle orientation.. In: . . MGI: J:228792
- Chen C; Lee GA; Pourmorady A; Sock E; Donoghue MJ. 2015. Orchestration of Neuronal Differentiation and Progenitor Pool Expansion in the Developing Cortex by SoxC Genes.. In: . . MGI: J:225805
- Chen Y; Huang WC; Sejourne J; Clipperton-Allen AE; Page DT. 2015. Pten Mutations Alter Brain Growth Trajectory and Allocation of Cell Types through Elevated beta-Catenin Signaling.. In: . . MGI: J:225815
- Chou SJ; Perez-Garcia CG; Kroll TT; O'Leary DD. 2009. Lhx2 specifies regional fate in Emx1 lineage of telencephalic progenitors generating cerebral cortex.. In: . . MGI: J:154611
- Cocas LA; Fernandez G; Barch M; Doll J; Zamora Diaz I; Pleasure SJ. 2016. Cell Type-Specific Circuit Mapping Reveals the Presynaptic Connectivity of Developing Cortical Circuits.. In: . . MGI: J:231657
- Cocas LA; Miyoshi G; Carney RS; Sousa VH; Hirata T; Jones KR; Fishell G; Huntsman MM; Corbin JG. 2009. Emx1-lineage progenitors differentially contribute to neural diversity in the striatum and amygdala.. In: . . MGI: J:157097
- D'Acunzo P; Badaloni A; Ferro M; Ripamonti M; Zimarino V; Malgaroli A; Consalez GG. 2014. A conditional transgenic reporter of presynaptic terminals reveals novel features of the mouse corticospinal tract.. In: . . MGI: J:206865
- De Marco Garcia NV; Priya R; Tuncdemir SN; Fishell G; Karayannis T. 2015. Sensory inputs control the integration of neurogliaform interneurons into cortical circuits.. In: . . MGI: J:221909
- Del Toro D; Ruff T; Cederfjall E; Villalba A; Seyit-Bremer G; Borrell V; Klein R. 2017. Regulation of Cerebral Cortex Folding by Controlling Neuronal Migration via FLRT Adhesion Molecules.. In: . . MGI: J:241499
- Depaepe V; Suarez-Gonzalez N; Dufour A; Passante L; Gorski JA; Jones KR; Ledent C; Vanderhaeghen P. 2005. Ephrin signalling controls brain size by regulating apoptosis of neural progenitors.. In: . . MGI: J:99355
- Ding Y; Qu Y; Feng J; Wang M; Han Q; So KF; Wu W; Zhou L. 2014. Functional motor recovery from motoneuron axotomy is compromised in mice with defective corticospinal projections.. In: . . MGI: J:218923
- Dissing-Olesen L; LeDue JM; Rungta RL; Hefendehl JK; Choi HB; MacVicar BA. 2014. Activation of neuronal NMDA receptors triggers transient ATP-mediated microglial process outgrowth.. In: . . MGI: J:215582
- Dudok JJ; Murtaza M; Henrique Alves C; Rashbass P; Wijnholds J. 2016. Crumbs 2 prevents cortical abnormalities in mouse dorsal telencephalon.. In: . . MGI: J:236353
- Elia LP; Yamamoto M; Zang K; Reichardt LF. 2006. p120 catenin regulates dendritic spine and synapse development through Rho-family GTPases and cadherins.. In: . . MGI: J:110469
- English CN; Vigers AJ; Jones KR. 2012. Genetic evidence that brain-derived neurotrophic factor mediates competitive interactions between individual cortical neurons.. In: . . MGI: J:192261
- Enriquez-Rios V; Dumitrache LC; Downing SM; Li Y; Brown EJ; Russell HR; McKinnon PJ. 2017. DNA-PKcs, ATM, and ATR Interplay Maintains Genome Integrity during Neurogenesis.. In: . . MGI: J:239152
- Falk S; Joosten E; Kaartinen V; Sommer L. 2014. Smad4 and Trim33/Tif1gamma redundantly regulate neural stem cells in the developing cortex.. In: . . MGI: J:226378
- Flore G; Di Ruberto G; Parisot J; Sannino S; Russo F; Illingworth EA; Studer M; De Leonibus E. 2017. Gradient COUP-TFI Expression Is Required for Functional Organization of the Hippocampal Septo-Temporal Longitudinal Axis.. In: . . MGI: J:241104
- Fu C; Ess KC. 2013. Conditional and domain-specific inactivation of the Tsc2 gene in neural progenitor cells.. In: . . MGI: J:195049
- Fuentes F; Zimmer D; Atienza M; Schottenfeld J; Penkala I; Bale T; Bence KK; Arregui CO. 2012. Protein tyrosine phosphatase PTP1B is involved in hippocampal synapse formation and learning.. In: . . MGI: J:189720
- Galazo MJ; Emsley JG; Macklis JD. 2016. Corticothalamic Projection Neuron Development beyond Subtype Specification: Fog2 and Intersectional Controls Regulate Intraclass Neuronal Diversity.. In: . . MGI: J:239715
- Garrett AM; Schreiner D; Lobas MA; Weiner JA. 2012. gamma-protocadherins control cortical dendrite arborization by regulating the activity of a FAK/PKC/MARCKS signaling pathway.. In: . . MGI: J:188387
- Gee JM; Smith NA; Fernandez FR; Economo MN; Brunert D; Rothermel M; Morris SC; Talbot A; Palumbos S; Ichida JM; Shepherd JD; West PJ; Wachowiak M; Capecchi MR; Wilcox KS; White JA; Tvrdik P. 2014. Imaging Activity in Neurons and Glia with a Polr2a-Based and Cre-Dependent GCaMP5G-IRES-tdTomato Reporter Mouse.. In: . . MGI: J:212315
- Genetic Resource Science at The Jackson Laboratory. 2008. Expression/Specificity Patterns of Cre Alleles. In: . . MGI: J:137887
- Genetic Resource Science at The Jackson Laboratory. 2012. Expression/Specificity Patterns of Cre Alleles, 2011. In: . . MGI: J:184578
- Gil-Sanz C; Espinosa A; Fregoso SP; Bluske KK; Cunningham CL; Martinez-Garay I; Zeng H; Franco SJ; Muller U. 2015. Lineage Tracing Using Cux2-Cre and Cux2-CreERT2 Mice.. In: . . MGI: J:223290
- Gil-Sanz C; Landeira B; Ramos C; Costa MR; Muller U. 2014. Proliferative defects and formation of a double cortex in mice lacking Mltt4 and Cdh2 in the dorsal telencephalon.. In: . . MGI: J:215584
- Goffin D; Brodkin ES; Blendy JA; Siegel SJ; Zhou Z. 2014. Cellular origins of auditory event-related potential deficits in Rett syndrome.. In: . . MGI: J:212933
- Golonzhka O; Nord A; Tang PL; Lindtner S; Ypsilanti AR; Ferretti E; Visel A; Selleri L; Rubenstein JL. 2015. Pbx Regulates Patterning of the Cerebral Cortex in Progenitors and Postmitotic Neurons.. In: . . MGI: J:228726
- Gong X; Zhang L; Huang T; Lin TV; Miyares L; Wen J; Hsieh L; Bordey A. 2015. Activating the translational repressor 4E-BP or reducing S6K-GSK3beta activity prevents accelerated axon growth induced by hyperactive mTOR in vivo.. In: . . MGI: J:226033
- Gorski JA; Balogh SA; Wehner JM; Jones KR. 2003. Learning deficits in forebrain-restricted brain-derived neurotrophic factor mutant mice.. In: . . MGI: J:100000
- Gorski JA; Zeiler SR; Tamowski S; Jones KR. 2003. Brain-derived neurotrophic factor is required for the maintenance of cortical dendrites.. In: . . MGI: J:84683
- Greer PL; Bear DM; Lassance JM; Bloom ML; Tsukahara T; Pashkovski SL; Masuda FK; Nowlan AC; Kirchner R; Hoekstra HE; Datta SR. 2016. A Family of non-GPCR Chemosensors Defines an Alternative Logic for Mammalian Olfaction.. In: . . MGI: J:234546
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- Han Q; Cao C; Ding Y; So KF; Wu W; Qu Y; Zhou L. 2015. Plasticity of motor network and function in the absence of corticospinal projection.. In: . . MGI: J:221606
- Hantman AW; Jessell TM. 2010. Clarke's column neurons as the focus of a corticospinal corollary circuit.. In: . . MGI: J:211843
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- Harris JA; Hirokawa KE; Sorensen SA; Gu H; Mills M; Ng LL; Bohn P; Mortrud M; Ouellette B; Kidney J; Smith KA; Dang C; Sunkin S; Bernard A; Oh SW; Madisen L; Zeng H. 2014. Anatomical characterization of Cre driver mice for neural circuit mapping and manipulation.. In: . . MGI: J:220523
- Harrison SJ; Nishinakamura R; Jones KR; Monaghan AP. 2012. Sall1 regulates cortical neurogenesis and laminar fate specification in mice: implications for neural abnormalities in Townes-Brocks syndrome.. In: . . MGI: J:179804
- Harwell CC; Parker PR; Gee SM; Okada A; McConnell SK; Kreitzer AC; Kriegstein AR. 2012. Sonic hedgehog expression in corticofugal projection neurons directs cortical microcircuit formation.. In: . . MGI: J:183457
- Hasenpusch-Theil K; Magnani D; Amaniti EM; Han L; Armstrong D; Theil T. 2012. Transcriptional analysis of Gli3 mutants identifies Wnt target genes in the developing hippocampus.. In: . . MGI: J:203028
- Hasenpusch-Theil K; Watson JA; Theil T. 2017. Direct Interactions Between Gli3, Wnt8b, and Fgfs Underlie Patterning of the Dorsal Telencephalon.. In: . . MGI: J:241042
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- Hippenmeyer S; Youn YH; Moon HM; Miyamichi K; Zong H; Wynshaw-Boris A; Luo L. 2010. Genetic mosaic dissection of lis1 and ndel1 in neuronal migration.. In: . . MGI: J:166047
- Histed MH; Maunsell JH. 2014. Cortical neural populations can guide behavior by integrating inputs linearly, independent of synchrony.. In: . . MGI: J:206379
- Houlihan SL; Lanctot AA; Guo Y; Feng Y. 2016. Upregulation of neurovascular communication through filamin abrogation promotes ectopic periventricular neurogenesis.. In: . . MGI: J:238096
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