JAX Mouse Strain Datasheet - 005628

B6.129S2-Emx1^tm1(cre)Krj/J

Stock No:: 005628 |; Emx1^{IRES cre}

Repository Live

Overview

Also Known As: Emx1^{IRES cre}

Emx1-IRES-Cre knockin mice have the endogenous Emx1 locus directing expression of Cre recombinase to approximately 88% of the neurons of the neocortex and hippocampus, and in the glial cells of the pallium. These mice are useful in studies of forebrain development and function.

Donating Investigator

Kevin R. Jones, University of Colorado- Boulder

Genetic overview

Genetic Background	Generation
	N12+N1F11 (03-APR-17)

Emx1^tm1(cre)Krj

Allele Type	Gene Symbol	Gene Name
Targeted (Recombinase-expressing)	Emx1	empty spiracles homeobox 1

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Research Applications

Neurobiology Research
Research Tools

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Base Price

Starting at:

$246.50 Domestic price for female

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Details

Detailed Description

Mice homozygous for the targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. This strain expresses Cre recombinase from the endogenous Emx1 locus. Western blot analysis of cortical brain tissue does not detect reduced endogenous gene product (protein). When crossed with a strain containing a loxP-site flanked sequence, Cre-mediated recombination results in tissue-specific deletion of the flanked sequence. Recombination occurs in approximately 88% of the neurons of the neocortex and hippocampus, and in the glial cells of the pallium, mimicking the pattern of expression of the endogenous gene. Further, the donating investigator reports that Cre recombinase is also expressed in a subset of male germline cells, thus some offspring from a cre; floxed male will have the floxed allele recombined in all cells. Our findings suggest that females may also be similarly affected. This mutant mouse strain represents a model that may be useful in studies of forebrain development and function.

View cre expression characterization.

Development

A targeting vector containing an internal ribosome entry site (IRES) sequence, Cre coding sequence, a polyadenlyation signal and a FRT site flanked PGK-neomycin cassette was inserted 120bp 3' from the stop codon, in the 3' untranslated region. The construct was electroporated into 129S2/SvPas derived D3 embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient blastocysts. The resulting chimeric animal was crossed to a Flp recombinase expressing strain (FLP-4917) to remove the selection cassette. The mice were then backcrossed to C57BL/6 mice for 12 generations.

Expression Data

Expressed Gene	cre, cre recombinase, bacteriophage P1
Site of Expression	neurons of the neocortex and hippocampus; some germline

Control Suggestions

000664 C57BL/6J

Additional Information

Considerations for Choosing Controls

Selected References

Gorski JA; Talley T; Qiu M; Puelles L; Rubenstein JL; Jones KR. 2002. Cortical excitatory neurons and glia, but not GABAergic neurons, are produced in the Emx1-expressing lineage. J Neurosci 22(15):6309-14. PubMed: 12151506 MGI: J:78098

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Genetics

Emx1^tm1(cre)Krj

Allele Symbol: Emx1^tm1(cre)Krj

Allele Name	targeted mutation 1, Kevin R Jones
Allele Type	Targeted (Recombinase-expressing)
Allele Synonym(s)	Emx1-IRES-Cre; Emx1^Cre; Emx1^IREScre; emx1-cre
Gene Symbol and Name	Emx1, empty spiracles homeobox 1
Gene Synonym(s)	RGD1564002
Expressed Gene	cre, cre recombinase, bacteriophage P1
Site of Expression	neurons of the neocortex and hippocampus; some germline
Strain of Origin	129S2/SvPas
Chromosome	6
Molecular Note	An IRES-cre gene followed by an FRT flanked PGK-neomycin gene was inserted 120 bp 3' of the stop codon. The neomycin gene was later removed in vivo by crossing to an Flp recombinase expressing transgenic strain. The protein product of this gene was produced in normal quantities as confirmed by Western blot analysis. Cre recombinase expression was characterized by crossing to a Rosa26 strain.
Mutations Made By	Kevin Jones, University of Colorado- Boulder

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Neurobiology Research
- Cre-lox System
  - Cre Recombinase expression in neural tissue
- Neurodevelopmental Defects
Research Tools
- Cre-lox System
  - Cre Recombinase Expression
  - Cre Recombinase Expression: Germline/Embryonic Expression
- Developmental Biology Research
  - Cre-lox System
- Neurobiology Research

Genotype: cre related

Research Tools
- Cre-lox System
- Genetics Research
  - Mutagenesis and Transgenesis
  - Mutagenesis and Transgenesis: Cre-lox System

Mammalian Phenotype Terms by Genotype

The following phenotype information is associated with a similar, but not exact match to this JAX^® Mice strain

Genotype: Emx1^tm1(cre)Krj/Emx1^tm1(cre)Krj
involves: 129S2/SvPas * C57BL/6

normal phenotype

no abnormal phenotype detected
- homozygous mice do not show any of the abnormal phenotypes shown for Emx1^tm1Jlr homozygotes

References

Gorski JA; Talley T; Qiu M; Puelles L; Rubenstein JL; Jones KR. 2002. Cortical excitatory neurons and glia, but not GABAergic neurons, are produced in the Emx1-expressing lineage. J Neurosci 22(15):6309-14. PubMed: 12151506 MGI: J:78098

Additional - Emx1^tm1(cre)Krj related

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Ahmari SE; Spellman T; Douglass NL; Kheirbek MA; Simpson HB; Deisseroth K; Gordon JA; Hen R. 2013. Repeated cortico-striatal stimulation generates persistent OCD-like behavior. Science 340(6137):1234-9. PubMed: 23744948 MGI: J:199177
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Amaniti EM; Fu C; Lewis S; Saisana M; Magnani D; Mason JO; Theil T. 2015. Expansion of the piriform cortex contributes to corticothalamic pathfinding defects in Gli3 conditional mutants. Cereb Cortex 25(2):460-71. PubMed: 24014668 MGI: J:229226
Amaniti EM; Hasenpusch-Theil K; Li Z; Magnani D; Kessaris N; Mason JO; Theil T. 2013. Gli3 is required in Emx1(+) progenitors for the development of the corpus callosum. Dev Biol 376(2):113-24. PubMed: 23396189 MGI: J:195145
Antoine MW; Hubner CA; Arezzo JC; Hebert JM. 2013. A causative link between inner ear defects and long-term striatal dysfunction. Science 341(6150):1120-3. PubMed: 24009395 MGI: J:201156
Armentano M; Chou SJ; Tomassy GS; Leingartner A; O'Leary DD; Studer M. 2007. COUP-TFI regulates the balance of cortical patterning between frontal/motor and sensory areas. Nat Neurosci 10(10):1277-86. PubMed: 17828260 MGI: J:127387
Armour EA; Carson RP; Ess KC. 2012. Cystogenesis and elongated primary cilia in Tsc1-deficient distal convoluted tubules. Am J Physiol Renal Physiol 303(4):F584-92. PubMed: 22674026 MGI: J:188431
Asinof SK; Sukoff Rizzo SJ; Buckley AR; Beyer BJ; Letts VA; Frankel WN; Boumil RM. 2015. Independent Neuronal Origin of Seizures and Behavioral Comorbidities in an Animal Model of a Severe Childhood Genetic Epileptic Encephalopathy. PLoS Genet 11(6):e1005347. PubMed: 26125563 MGI: J:224850
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Also Known As: Emx1IRES cre

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Emx1tm1(cre)Krj

Allele Symbol: Emx1tm1(cre)Krj

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Genotype: cre related

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Genotype: Emx1tm1(cre)Krj/Emx1tm1(cre)Krjinvolves: 129S2/SvPas * C57BL/6

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Also Known As: Emx1^{IRES cre}

Emx1^tm1(cre)Krj

Allele Symbol: Emx1^tm1(cre)Krj

Genotype: Emx1^tm1(cre)Krj/Emx1^tm1(cre)Krj
involves: 129S2/SvPas * C57BL/6

Additional - Emx1^tm1(cre)Krj related