JAX Mouse Strain Datasheet - 005582

B6.129P-Cx3cr1^tm1Litt/J

Stock No:: 005582 |; CX3CR1-GFP

Repository Live

Overview

Also Known As: CX3CR1-GFP

These CX3CR1-GFP mice express EGFP in monocytes, dendritic cells, NK cells, and brain microglia under control of the endogenous Cx3cr1 locus. They may be useful in studies of leukocyte migration and trafficking, as well as for transplantation studies.

Donating Investigator

Dr. Dan R. Littman, New York University Medical Center

Genetic overview

Genetic Background	Generation
	N12F10 (16-MAY-16)

Cx3cr1^tm1Litt

Allele Type	Gene Symbol	Gene Name
Targeted (Null/Knockout, Reporter)	Cx3cr1	chemokine (C-X3-C motif) receptor 1

View Genetics

Research Applications

Cancer Research
Immunology, Inflammation and Autoimmunity Research
Neurobiology Research
Research Tools

View All Research Applications

Base Price

Starting at:

$213.00 Domestic price for female 4-week

View Price List

Details

Detailed Description

Mice that are homozygous for the CX3CR1-GFP targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. RT-PCR analysis of lymphoid tissue from homozygotes detects mutant gene product (mRNA) and no wild type gene product (mRNA). Flow cytometric analysis of peripheral blood cells identified a subset of green fluorescent cells not observed in wild type mice. Enhanced Green Fluorescent Protein (EGFP), but not the endogenous gene, is expressed in monocytes, dendritic cells, NK cells, and brain microglia, mimicking endogenous gene expression. The same subset of peripheral blood cells isolated from heterozygote mice express detectable levels of EGFP. These CX3CR1-GFP mutant mice may be useful in studies of leukocyte migration and trafficking, as well as for transplantation studies.

Of note, CX3CR1-GFP mice are also available harboring with the CD45.1 (Ly5.1 or Ptprc^a) allele, which is atypical for the C57BL/6 congenic background (see Stock No. 008451).

When compared with GFP expression in monocytes in C57BL/6-Tg(CD68-EGFP)1Drg/J mice (Stock No. 026827) using a sterile zymosan peritonitis model, CD68-GFP monocytes retain high-level GFP expression as they differentiate to become mature macrophages, while, CX₃CR1^GFP monocytes downregulate GFP expression on differentiation into macrophages.

Development

A targeting vector containing an Enhanced Green Fluorescent Protein (EGFP, Clontech) cDNA sequence, loxP-flanked neomycin resistance gene, herpes simplex virus thymidine kinase gene, and SV40 polyadenylation site sequence was used to disrupt the first 390 bp of exon 2. The construct was electroporated into 129P2/OlaHsd derived E14.1 embryonic stem (ES) cells which were transiently transfected with a Cre recombinase vector to remove the selection cassette. ES cells that had successfully undergone Cre-mediated recombination (removing the loxP-flanked neo cassette and leaving a single loxP site downstream of EGFP) were injected into recipient blastocysts. The donating investigator reported that resulting chimeric animals were backcrossed to C57BL/6 (see SNP note below) for ten generations before being made homozygous. During the backcross, mice were likely bred to a B6.CD45.1 congenic strain (harboring the CD45.1 (Ly5.1 or Ptprc^a) allele rather than the CD45.2 (Ly5.2 or Ptprc^b) allele normally present in C57BL/6 mice). These mice, however, were bred such that they still harbor the expected CD45.2 (Ly5.2 or Ptprc^b) allele normally present in C57BL/6 mice.

In 2011, a 32 SNP (single nucleotide polymorphism) panel analysis, with 27 markers covering all 19 chromosomes and the X chromosome, as well as 5 markers that distinguish between the C57BL/6J and C57BL/6N substrains, was performed on the rederived living colony at The Jackson Laboratory Repository. While the 27 markers throughout the genome suggested a C57BL/6 genetic background, 2 of 5 markers that determine C57BL/6J from C57BL/6N were found to be segregating. These data suggest the mice sent to The Jackson Laboratory Repository were on a C57BL/6N genetic background or a mixed C57BL/6J;C57BL/6N genetic background. In 2013, the same SNP panel analysis showed 4 of 5 markers that determine C57BL/6J from C57BL/6N were segregating. The living colony is on a mixed C57BL/6J;C57BL/6N genetic background.

Expression Data

Expressed Gene	GFP, Green Fluorescent Protein,
Site of Expression	GFP labels T and B cells in the lymphoid organs such as spleen, small intestine, and large intestine.

Control Suggestions

Approximate Controls

Additional Information

Considerations for Choosing Controls

Selected References

Jung S; Aliberti J; Graemmel P; Sunshine MJ; Kreutzberg GW; Sher A; Littman DR. 2000. Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. Mol Cell Biol 20(11):4106-14. PubMed: 10805752 MGI: J:84544

View All References

Genetics

Cx3cr1^tm1Litt

Allele Symbol: Cx3cr1^tm1Litt

Allele Name	targeted mutation 1, Dan R Littman
Allele Type	Targeted (Null/Knockout, Reporter)
Allele Synonym(s)	CX3CR-GFP; CX3CR1-EGFP; CX3CR1-GFP; CX3CR1^-; CX3CR1^EGFP; CX3CR1^GFP; Cx3cr1^gfp
Gene Symbol and Name	Cx3cr1, chemokine (C-X3-C motif) receptor 1
Gene Synonym(s)	CCRL1; CMKBRL1; CMKDR1; GPR13; GPRV28; Rbs11; V28
Expressed Gene	GFP, Green Fluorescent Protein,
Site of Expression	GFP labels T and B cells in the lymphoid organs such as spleen, small intestine, and large intestine.
Strain of Origin	129P2/OlaHsd
Chromosome	9
General Note	Phenotypic Similarity to Human Syndrome: Macular Degeneration, Geographic Atrophy, Dry Type (J:200877)
Molecular Note	The endogenous locus was disrupted by the insertion of sequence encoding green fluourescent protein (GFP), replacing the first 390 bp of the coding exon (exon 2). The deleted region encoded an amino-terminal portion of the protein that is crucial for interaction with endogenous ligand, Cx3cl1. A floxed neo gene included in the targeting vector for selection was excised prior to germline transmission, leaving a single loxP site downstream of the GFP sequence. RT-PCR and flow cytometry indicated an absence of endogenous protein and the presence GFP expression in homozygous mutant mice.
Mutations Made By	Steffen Jung, Weizmann Institute of Science

Disease/Phenotype

Disease Terms

Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Cancer Research
- Growth Factors/Receptors/Cytokines
- Toxicology
  - xenograft/transplant host
Immunology, Inflammation and Autoimmunity Research
- Growth Factors/Receptors/Cytokines
- Immunodeficiency
  - NK Cell Deficiency
Neurobiology Research
- Alzheimer's Disease
Research Tools
- Cancer Research
  - B, T, and NK cell deficiency, xenograft/transplant host
  - xenograft/transplant host
- Cell Biology Research
- Developmental Biology Research
  - transplantation marker for embryonic and adult tissue
- Fluorescent Proteins
- Genetics Research
  - Tissue/Cell Markers
  - Tissue/Cell Markers: cell marker for bone marrow transplantation
  - Tissue/Cell Markers: glial cells
  - Tissue/Cell Markers: multiple
  - Tissue/Cell Markers: neurons
  - Tissue/Cell Markers: transplantation marker for embryonic and adult tissue
- Immunology, Inflammation and Autoimmunity Research
  - NK Cell Deficiency
- Neurobiology Research
  - cell marker
- Toxicology Research
  - xenograft/transplant host

Genotype: GFP related

Research Tools
- Fluorescent Proteins

Mammalian Phenotype Terms by Genotype

Genotype: Cx3cr1^tm1Litt/Cx3cr1⁺
B6.129P2-Cx3cr1^tm1Litt

nervous system phenotype

microgliosis
- moderate following LPS exposure

immune system phenotype

increased susceptibility to experimental autoimmune encephalomyelitis
- following induction of experimental autoimmune encephalomyelitis (EAE), mice exhibit intermediate EAE severity (including transient flaccid paresis) compared with homozygous and wild-type mice
- mice treated with anti-NK1.1 antibodies exhibit the same severity of EAE as in homozygous mice following induction of experimental autoimmune encephalomyelitis

microgliosis
- moderate following LPS exposure

behavior/neurological phenotype

paresis
- following induction of experimental autoimmune encephalomyelitis, mice exhibit transient flaccid paresis

hematopoietic system phenotype

microgliosis
- moderate following LPS exposure

Genotype: Cx3cr1^tm1Litt/Cx3cr1^tm1Litt
B6.129P-Cx3cr1^tm1Litt/J

homeostasis/metabolism phenotype

homeostasis/metabolism phenotype
- mice exhibit normal response (dopamine nerve loss, increased body temperature, and microgliosis) to methamphetamine treatment

Genotype: Cx3cr1^tm1Litt/Cx3cr1^tm1Litt
B6.129P2-Cx3cr1^tm1Litt

mortality/aging

increased sensitivity to induced morbidity/mortality
- following induction of experimental autoimmune encephalomyelitis

nervous system phenotype

abnormal microglial cell physiology
- however, adoptive transfer into Il1r null mice restores microglial cell migration
- migration of microglial cells in LPS-treated mice is impaired unlike in similarly treated heterozygous mice

brain inflammation
- following induction of experimental autoimmune encephalomyelitis

brainstem hemorrhage
- following induction of experimental autoimmune encephalomyelitis

demyelination
- following induction of experimental autoimmune encephalomyelitis, mice exhibit more severe demyelination compared with similarly treated wild-type mice

increased neuron apoptosis
- LPS-induced neurotoxicity is cell-autonomous
- following LPS exposure, neuron apoptosis is increased unlike in heterozygous mice
- however, adoptive transfer into Il1r null mice abolishes neuron apoptosis
- however, mice subjected to adoptive transfer experiments and treated with an IL1 receptor antagonist exhibit reduced neuron apoptosis

increased susceptibility to dopaminergic neuron neurotoxicity
- mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) exhibit more severe neurotoxicity than similarly treated wild-type mice

microgliosis
- intense and widespread following LPS exposure

immune system phenotype

abnormal NK cell physiology
- following induction of experimental autoimmune encephalomyelitis, recruitment of NK cells is impaired compared to in similarly treated wild-type mice

abnormal leukocyte physiology
- following arterial injury, monocyte recruitment is impaired compared to in similarly treated wild-type mice

abnormal microglial cell physiology
- however, adoptive transfer into Il1r null mice restores microglial cell migration
- migration of microglial cells in LPS-treated mice is impaired unlike in similarly treated heterozygous mice

brain inflammation
- following induction of experimental autoimmune encephalomyelitis

decreased NK cell number
- in the central nervous system following induction of experimental autoimmune encephalomyelitis

immune system phenotype
- mice exhibit normal response to murine cytomegalovirus infection

increased susceptibility to experimental autoimmune encephalomyelitis
- following induction of experimental autoimmune encephalomyelitis, mice exhibit earlier onset, higher mortality, and more severe EAE symptoms (nonremitting spastic paralysis, increased hemorrhagic inflammation, and extensive demyelination) compared with similarly treated wild-type micemilarly treated wild-type mice
- following induction of experimental autoimmune encephalomyelitis, recruitment of NK cells is impaired compared to in similarly treated wild-type mice
- however, priming of encephalitogenic T cells and NKT cell numbers are normal

microgliosis
- intense and widespread following LPS exposure

cardiovascular system phenotype

abnormal vascular smooth muscle physiology
- following arterial injury, vascular smooth muscle cell proliferation is decreased compared to in similarly treated wild-type mice
- in vitro, vascular smooth muscle cells fail to proliferate in response to CXCL1 unlike similarly treated wild-type cells

abnormal vascular wound healing
- following arterial injury, mice exhibit decreased intimal hyperplasia, impaired monocyte recruitment into the vascular wall, and decreased vascular smooth muscle cell proliferation compared to in similarly treated wild-type mice
- however, mice exhibit normal luminal and medial areas and platelet function

brainstem hemorrhage
- following induction of experimental autoimmune encephalomyelitis

homeostasis/metabolism phenotype

abnormal vascular wound healing
- following arterial injury, mice exhibit decreased intimal hyperplasia, impaired monocyte recruitment into the vascular wall, and decreased vascular smooth muscle cell proliferation compared to in similarly treated wild-type mice
- however, mice exhibit normal luminal and medial areas and platelet function

increased susceptibility to dopaminergic neuron neurotoxicity
- mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) exhibit more severe neurotoxicity than similarly treated wild-type mice

behavior/neurological phenotype

paralysis
- following induction of experimental autoimmune encephalomyelitis, mice exhibit nonremitting spastic paralysis

hematopoietic system phenotype

abnormal NK cell physiology
- following induction of experimental autoimmune encephalomyelitis, recruitment of NK cells is impaired compared to in similarly treated wild-type mice

abnormal leukocyte physiology
- following arterial injury, monocyte recruitment is impaired compared to in similarly treated wild-type mice

abnormal microglial cell physiology
- however, adoptive transfer into Il1r null mice restores microglial cell migration
- migration of microglial cells in LPS-treated mice is impaired unlike in similarly treated heterozygous mice

decreased NK cell number
- in the central nervous system following induction of experimental autoimmune encephalomyelitis

microgliosis
- intense and widespread following LPS exposure

muscle phenotype

abnormal vascular smooth muscle physiology
- following arterial injury, vascular smooth muscle cell proliferation is decreased compared to in similarly treated wild-type mice
- in vitro, vascular smooth muscle cells fail to proliferate in response to CXCL1 unlike similarly treated wild-type cells

cellular phenotype

increased neuron apoptosis
- LPS-induced neurotoxicity is cell-autonomous
- following LPS exposure, neuron apoptosis is increased unlike in heterozygous mice
- however, adoptive transfer into Il1r null mice abolishes neuron apoptosis
- however, mice subjected to adoptive transfer experiments and treated with an IL1 receptor antagonist exhibit reduced neuron apoptosis

increased susceptibility to dopaminergic neuron neurotoxicity
- mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) exhibit more severe neurotoxicity than similarly treated wild-type mice

The following phenotype information is associated with a similar, but not exact match to this JAX^® Mice strain

Genotype: Cx3cr1^tm1Litt/Cx3cr1^tm1Litt
involves: 129P2/OlaHsd * C57BL/6

immune system phenotype

abnormal leukocyte physiology
- following kidney ischemia and reperfusion, mice exhibit reduced monocyte egress from the blood into the inflamed kidney compared with similarly treated wild-type mice

decreased monocyte cell number
- Gr1^low monocytes are reduced 3-fold compared to in wild-type mice
- however, expression of Tg(S100A8-BCL2)1Lgs restores monocyte numbers
- mice exhibit a reduction in the number of total monocytes compared with wild-type mice

immune system phenotype
- normal Langerhans cell migration and APC function in response to contact sensitizer (oxazolone)
- normal dendritic cell migration and IL-12 production in response to a microbial antigen (STAg)

impaired macrophage chemotaxis
- following kidney ischemia and reperfusion

homeostasis/metabolism phenotype

decreased susceptibility to kidney reperfusion injury
- following kidney ischemia and reperfusion, mice exhibit decreased kidney injury, tubular cell necrosis, and macrophage recruitment compared with similarly treated heterozygous mice

vision/eye phenotype

abnormal retina morphology
- following laser injury, more subretinal microglial cells accumulate adjacent to the choroid scar than in heterozygous mice at 7 and 14 days post injury
- subretinal microglial cells accumulate with age in the retina unlike in wild-type mice

choroidal neovascularization
- following laser injury, more subretinal microglial cells accumulate adjacent to the choroid scar than in similarly treated wild-type mice and choroid neovascularization is twice as much as in similarly treated wild-type mice

renal/urinary system phenotype

decreased susceptibility to kidney reperfusion injury
- following kidney ischemia and reperfusion, mice exhibit decreased kidney injury, tubular cell necrosis, and macrophage recruitment compared with similarly treated heterozygous mice

nervous system phenotype

nervous system phenotype
- normal neuronal-glial cross talk indicated by microglial response to peripheral nerve injury, 129P2/OlaHsd and C57BL/6 mixed genetic background

cardiovascular system phenotype

choroidal neovascularization
- following laser injury, more subretinal microglial cells accumulate adjacent to the choroid scar than in similarly treated wild-type mice and choroid neovascularization is twice as much as in similarly treated wild-type mice

hematopoietic system phenotype

abnormal leukocyte physiology
- following kidney ischemia and reperfusion, mice exhibit reduced monocyte egress from the blood into the inflamed kidney compared with similarly treated wild-type mice

decreased monocyte cell number
- Gr1^low monocytes are reduced 3-fold compared to in wild-type mice
- however, expression of Tg(S100A8-BCL2)1Lgs restores monocyte numbers
- mice exhibit a reduction in the number of total monocytes compared with wild-type mice

impaired macrophage chemotaxis
- following kidney ischemia and reperfusion

cellular phenotype

impaired macrophage chemotaxis
- following kidney ischemia and reperfusion

Genotype: Cx3cr1^tm1Litt/Cx3cr1^tm1Litt
C.129P2-Cx3cr1^tm1Litt

immune system phenotype

immune system phenotype
- normal monocyte extravasation and subsequent differentiation into macrophages in response to intraperitoneal injection of thioglycolate, a model of acute peritonitis

Genotype: Cx3cr1^tm1Litt/Cx3cr1^tm1Litt
involves: 129P2/OlaHsd

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality
- S. typhimurium-infected mice exhibit a higher organ bacterial load and die within 6 days of infection unlike similarly treated heterozygous and wild-type mice

immune system phenotype

abnormal dendritic cell physiology
- S. typhimurium-infected mice exhibit laminar propria dendritic cells that only form globular structures that fail to cross the epithelium unlike in similarly treated heterozygous mice
- however, sampling of E. coli into the Peyer Patches is normal
- ileal villi lack intraepithelial dendritic cell extensions unlike in heterozygous mice
- laminar propria dendritic cells exhibit impaired capacity to traverse the epithelial cell monolayer unlike in heterozygous mice
- laminar propria dendritic cells fail to properly sample E. coli unlike in heterozygous mice

increased dendritic cell number
- antibiotic-treated mice exhibit increased numbers of all subsets of dendritic cells in the mesenteric lymph nodes as compared to untreated controls
- mice treated with antibiotic and infected with non-invasive Salmonella exhibit increased numbers of only CX3CR1 cells in the mesenteric lymph nodes and afferent lymph nodes as compared to uninfected controls

increased susceptibility to bacterial infection induced morbidity/mortality
- S. typhimurium-infected mice exhibit a higher organ bacterial load and die within 6 days of infection unlike similarly treated heterozygous and wild-type mice

digestive/alimentary phenotype

abnormal small intestinal villus morphology
- ileal villi lack intraepithelial dendritic cell extensions unlike in heterozygous mice

hematopoietic system phenotype

increased dendritic cell number
- antibiotic-treated mice exhibit increased numbers of all subsets of dendritic cells in the mesenteric lymph nodes as compared to untreated controls
- mice treated with antibiotic and infected with non-invasive Salmonella exhibit increased numbers of only CX3CR1 cells in the mesenteric lymph nodes and afferent lymph nodes as compared to uninfected controls

References

Jung S; Aliberti J; Graemmel P; Sunshine MJ; Kreutzberg GW; Sher A; Littman DR. 2000. Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. Mol Cell Biol 20(11):4106-14. PubMed: 10805752 MGI: J:84544

Additional - Cx3cr1^tm1Litt related

A-Gonzalez N; Guillen JA; Gallardo G; Diaz M; de la Rosa JV; Hernandez IH; Casanova-Acebes M; Lopez F; Tabraue C; Beceiro S; Hong C; Lara PC; Andujar M; Arai S; Miyazaki T; Li S; Corbi AL; Tontonoz P; Hidalgo A; Castrillo A. 2013. The nuclear receptor LXRalpha controls the functional specialization of splenic macrophages. Nat Immunol 14(8):831-9. PubMed: 23770640 MGI: J:204819
Abiega O; Beccari S; Diaz-Aparicio I; Nadjar A; Laye S; Leyrolle Q; Gomez-Nicola D; Domercq M; Perez-Samartin A; Sanchez-Zafra V; Paris I; Valero J; Savage JC; Hui CW; Tremblay ME; Deudero JJ; Brewster AL; Anderson AE; Zaldumbide L; Galbarriatu L; Marinas A; Vivanco Md; Matute C; Maletic-Savatic M; Encinas JM; Sierra A. 2016. Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling. PLoS Biol 14(5):e1002466. PubMed: 27228556 MGI: J:236323
Afik R; Zigmond E; Vugman M; Klepfish M; Shimshoni E; Pasmanik-Chor M; Shenoy A; Bassat E; Halpern Z; Geiger T; Sagi I; Varol C. 2016. Tumor macrophages are pivotal constructors of tumor collagenous matrix. J Exp Med 213(11):2315-2331. PubMed: 27697834 MGI: J:237417
Alt C; Runnels JM; Mortensen LJ; Zaher W; Lin CP. 2014. In vivo imaging of microglia turnover in the mouse retina after ionizing radiation and dexamethasone treatment. Invest Ophthalmol Vis Sci 55(8):5314-9. PubMed: 25082884 MGI: J:230246
An G; Wang H; Tang R; Yago T; McDaniel JM; McGee S; Huo Y; Xia L. 2008. P-selectin glycoprotein ligand-1 is highly expressed on Ly-6Chi monocytes and a major determinant for Ly-6Chi monocyte recruitment to sites of atherosclerosis in mice. Circulation 117(25):3227-37. PubMed: 18519846 MGI: J:155081
Arno B; Grassivaro F; Rossi C; Bergamaschi A; Castiglioni V; Furlan R; Greter M; Favaro R; Comi G; Becher B; Martino G; Muzio L. 2014. Neural progenitor cells orchestrate microglia migration and positioning into the developing cortex. Nat Commun 5:5611. PubMed: 25425146 MGI: J:225279
Arnold L; Henry A; Poron F; Baba-Amer Y; van Rooijen N; Plonquet A; Gherardi RK; Chazaud B. 2007. Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis. J Exp Med 204(5):1057-69. PubMed: 17485518 MGI: J:125715
Arnold L; Perrin H; de Chanville CB; Saclier M; Hermand P; Poupel L; Guyon E; Licata F; Carpentier W; Vilar J; Mounier R; Chazaud B; Benhabiles N; Boissonnas A; Combadiere B; Combadiere C. 2015. CX3CR1 deficiency promotes muscle repair and regeneration by enhancing macrophage ApoE production. Nat Commun 6:8972. PubMed: 26632270 MGI: J:228319
Asano K; Takahashi N; Ushiki M; Monya M; Aihara F; Kuboki E; Moriyama S; Iida M; Kitamura H; Qiu CH; Watanabe T; Tanaka M. 2015. Intestinal CD169(+) macrophages initiate mucosal inflammation by secreting CCL8 that recruits inflammatory monocytes. Nat Commun 6:7802. PubMed: 26193821 MGI: J:224450
Auffray C; Fogg DK; Narni-Mancinelli E; Senechal B; Trouillet C; Saederup N; Leemput J; Bigot K; Campisi L; Abitbol M; Molina T; Charo I; Hume DA; Cumano A; Lauvau G; Geissmann F. 2009. CX3CR1+ CD115+ CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation. J Exp Med 206(3):595-606. PubMed: 19273628 MGI: J:146747
Avraham-Davidi I; Yona S; Grunewald M; Landsman L; Cochain C; Silvestre JS; Mizrahi H; Faroja M; Strauss-Ayali D; Mack M; Jung S; Keshet E. 2013. On-site education of VEGF-recruited monocytes improves their performance as angiogenic and arteriogenic accessory cells. J Exp Med 210(12):2611-25. PubMed: 24166715 MGI: J:207718
Baalman K; Marin MA; Ho TS; Godoy M; Cherian L; Robertson C; Rasband MN. 2015. Axon initial segment-associated microglia. J Neurosci 35(5):2283-92. PubMed: 25653382 MGI: J:219895
Baik SH; Kang S; Son SM; Mook-Jung I. 2016. Microglia contributes to plaque growth by cell death due to uptake of amyloid beta in the brain of Alzheimer's disease mouse model. Glia 64(12):2274-2290. PubMed: 27658617 MGI: J:236228
Baldwin KT; Carbajal KS; Segal BM; Giger RJ. 2015. Neuroinflammation triggered by beta-glucan/dectin-1 signaling enables CNS axon regeneration. Proc Natl Acad Sci U S A 112(8):2581-6. PubMed: 25675510 MGI: J:220172
Bar-On L; Birnberg T; Lewis KL; Edelson BT; Bruder D; Hildner K; Buer J; Murphy KM; Reizis B; Jung S. 2010. CX3CR1+ CD8alpha+ dendritic cells are a steady-state population related to plasmacytoid dendritic cells. Proc Natl Acad Sci U S A 107(33):14745-50. PubMed: 20679228 MGI: J:163703
Baron R; Babcock AA; Nemirovsky A; Finsen B; Monsonego A. 2014. Accelerated microglial pathology is associated with Abeta plaques in mouse models of Alzheimer's disease. Aging Cell 13(4):584-95. PubMed: 24641683 MGI: J:215081
Batti L; Sundukova M; Murana E; Pimpinella S; De Castro Reis F; Pagani F; Wang H; Pellegrino E; Perlas E; Di Angelantonio S; Ragozzino D; Heppenstall PA. 2016. TMEM16F Regulates Spinal Microglial Function in Neuropathic Pain States. Cell Rep 15(12):2608-15. PubMed: 27332874 MGI: J:238366
Bergsbaken T; Bevan MJ. 2015. Proinflammatory microenvironments within the intestine regulate the differentiation of tissue-resident CD8(+) T cells responding to infection. Nat Immunol 16(4):406-14. PubMed: 25706747 MGI: J:231497
Berta T; Park CK; Xu ZZ; Xie RG; Liu T; Lu N; Liu YC; Ji RR. 2014. Extracellular caspase-6 drives murine inflammatory pain via microglial TNF-alpha secretion. J Clin Invest 124(3):1173-86. PubMed: 24531553 MGI: J:209726
Bertrand JY; Jalil A; Klaine M; Jung S; Cumano A; Godin I. 2005. Three pathways to mature macrophages in the early mouse yolk sac. Blood 106(9):3004-11. PubMed: 16020514 MGI: J:123941
Bhaskar K; Konerth M; Kokiko-Cochran ON; Cardona A; Ransohoff RM; Lamb BT. 2010. Regulation of tau pathology by the microglial fractalkine receptor. Neuron 68(1):19-31. PubMed: 20920788 MGI: J:167757
Blomster LV; Vukovic J; Hendrickx DA; Jung S; Harvey AR; Filgueira L; Ruitenberg MJ. 2011. CX(3)CR1 deficiency exacerbates neuronal loss and impairs early regenerative responses in the target-ablated olfactory epithelium. Mol Cell Neurosci 48(3):236-45. PubMed: 21871566 MGI: J:189381
Bogunovic M; Ginhoux F; Helft J; Shang L; Hashimoto D; Greter M; Liu K; Jakubzick C; Ingersoll MA; Leboeuf M; Stanley ER; Nussenzweig M; Lira SA; Randolph GJ; Merad M. 2009. Origin of the lamina propria dendritic cell network. Immunity 31(3):513-25. PubMed: 19733489 MGI: J:152688
Bonnardel J; Da Silva C; Henri S; Tamoutounour S; Chasson L; Montanana-Sanchis F; Gorvel JP; Lelouard H. 2015. Innate and adaptive immune functions of peyer's patch monocyte-derived cells. Cell Rep 11(5):770-84. PubMed: 25921539 MGI: J:228363
Bosco A; Crish SD; Steele MR; Romero CO; Inman DM; Horner PJ; Calkins DJ; Vetter ML. 2012. Early reduction of microglia activation by irradiation in a model of chronic glaucoma. PLoS One 7(8):e43602. PubMed: 22952717 MGI: J:191663
Bosco A; Romero CO; Breen KT; Chagovetz AA; Steele MR; Ambati BK; Vetter ML. 2015. Neurodegeneration severity can be predicted from early microglia alterations monitored in vivo in a mouse model of chronic glaucoma. Dis Model Mech 8(5):443-55. PubMed: 25755083 MGI: J:221352
Bottcher JP; Beyer M; Meissner F; Abdullah Z; Sander J; Hochst B; Eickhoff S; Rieckmann JC; Russo C; Bauer T; Flecken T; Giesen D; Engel D; Jung S; Busch DH; Protzer U; Thimme R; Mann M; Kurts C; Schultze JL; Kastenmuller W; Knolle PA. 2015. Functional classification of memory CD8(+) T cells by CX3CR1 expression. Nat Commun 6:8306. PubMed: 26404698 MGI: J:227216
Bradfield PF; Scheiermann C; Nourshargh S; Ody C; Luscinskas FW; Rainger GE; Nash GB; Miljkovic-Licina M; Aurrand-Lions M; Imhof BA. 2007. JAM-C regulates unidirectional monocyte transendothelial migration in inflammation. Blood 110(7):2545-55. PubMed: 17625065 MGI: J:147010
Broz ML; Binnewies M; Boldajipour B; Nelson AE; Pollack JL; Erle DJ; Barczak A; Rosenblum MD; Daud A; Barber DL; Amigorena S; Van't Veer LJ; Sperling AI; Wolf DM; Krummel MF. 2014. Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity. Cancer Cell 26(5):638-52. PubMed: 25446897 MGI: J:217466
Burguillos MA; Svensson M; Schulte T; Boza-Serrano A; Garcia-Quintanilla A; Kavanagh E; Santiago M; Viceconte N; Oliva-Martin MJ; Osman AM; Salomonsson E; Amar L; Persson A; Blomgren K; Achour A; Englund E; Leffler H; Venero JL; Joseph B; Deierborg T. 2015. Microglia-Secreted Galectin-3 Acts as a Toll-like Receptor 4 Ligand and Contributes to Microglial Activation. Cell Rep :. PubMed: 25753426 MGI: J:228186
Butovsky O; Siddiqui S; Gabriely G; Lanser AJ; Dake B; Murugaiyan G; Doykan CE; Wu PM; Gali RR; Iyer LK; Lawson R; Berry J; Krichevsky AM; Cudkowicz ME; Weiner HL. 2012. Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS. J Clin Invest 122(9):3063-87. PubMed: 22863620 MGI: J:191300
Cabanski M; Wilhelm J; Zaslona Z; Steinmuller M; Fink L; Seeger W; Lohmeyer J. 2009. Genome-wide transcriptional profiling of mononuclear phagocytes recruited to mouse lungs in response to alveolar challenge with the TLR2 agonist Pam3CSK4. Am J Physiol Lung Cell Mol Physiol 297(4):L608-18. PubMed: 19617307 MGI: J:154138
Cain DW; O'Koren EG; Kan MJ; Womble M; Sempowski GD; Hopper K; Gunn MD; Kelsoe G. 2013. Identification of a tissue-specific, C/EBPbeta-dependent pathway of differentiation for murine peritoneal macrophages. J Immunol 191(9):4665-75. PubMed: 24078688 MGI: J:206241
Cardona AE; Pioro EP; Sasse ME; Kostenko V; Cardona SM; Dijkstra IM; Huang D; Kidd G; Dombrowski S; Dutta R; Lee JC; Cook DN; Jung S; Lira SA; Littman DR; Ransohoff RM. 2006. Control of microglial neurotoxicity by the fractalkine receptor. Nat Neurosci 9(7):917-24. PubMed: 16732273 MGI: J:110266
Cardona AE; Sasse ME; Liu L; Cardona SM; Mizutani M; Savarin C; Hu T; Ransohoff RM. 2008. Scavenging roles of chemokine receptors: chemokine receptor deficiency is associated with increased levels of ligand in circulation and tissues. Blood 112(2):256-63. PubMed: 18347198 MGI: J:138467
Carlin LM; Stamatiades EG; Auffray C; Hanna RN; Glover L; Vizcay-Barrena G; Hedrick CC; Cook HT; Diebold S; Geissmann F. 2013. Nr4a1-dependent Ly6C(low) monocytes monitor endothelial cells and orchestrate their disposal. Cell 153(2):362-75. PubMed: 23582326 MGI: J:197367
Carreras E; Turner S; Paharkova-Vatchkova V; Mao A; Dascher C; Kovats S. 2008. Estradiol acts directly on bone marrow myeloid progenitors to differentially regulate GM-CSF or Flt3 ligand-mediated dendritic cell differentiation. J Immunol 180(2):727-38. PubMed: 18178810 MGI: J:130951
Chang KC; Shieh B; Petrash JM. 2016. Aldose reductase mediates retinal microglia activation. Biochem Biophys Res Commun 473(2):565-71. PubMed: 27033597 MGI: J:234967
Chang SY; Song JH; Guleng B; Cotoner CA; Arihiro S; Zhao Y; Chiang HS; O'Keeffe M; Liao G; Karp CL; Kweon MN; Sharpe AH; Bhan A; Terhorst C; Reinecker HC. 2013. Circulatory antigen processing by mucosal dendritic cells controls CD8(+) T cell activation. Immunity 38(1):153-65. PubMed: 23246312 MGI: J:192535
Chen M; Hombrebueno JR; Luo C; Penalva R; Zhao J; Colhoun L; Pandi SP; Forrester JV; Xu H. 2013. Age- and light-dependent development of localised retinal atrophy in CCL2(-/-)CX3CR1(GFP/GFP) mice. PLoS One 8(4):e61381. PubMed: 23637822 MGI: J:200877
Chen M; Luo C; Penalva R; Xu H. 2013. Paraquat-induced retinal degeneration is exaggerated in CX3CR1-deficient mice and is associated with increased retinal inflammation. Invest Ophthalmol Vis Sci 54(1):682-90. PubMed: 23299473 MGI: J:214566
Chen M; Zhao J; Luo C; Pandi SP; Penalva RG; Fitzgerald DC; Xu H. 2012. Para-inflammation-mediated retinal recruitment of bone marrow-derived myeloid cells following whole-body irradiation is CCL2 dependent. Glia 60(5):833-42. PubMed: 22362506 MGI: J:181628
Chen X; Zhang L; Zhang IY; Liang J; Wang H; Ouyang M; Wu S; da Fonseca AC; Weng L; Yamamoto Y; Yamamoto H; Natarajan R; Badie B. 2014. RAGE expression in tumor-associated macrophages promotes angiogenesis in glioma. Cancer Res 74(24):7285-97. PubMed: 25326491 MGI: J:218090
Cheret C; Gervais A; Lelli A; Colin C; Amar L; Ravassard P; Mallet J; Cumano A; Krause KH; Mallat M. 2008. Neurotoxic activation of microglia is promoted by a nox1-dependent NADPH oxidase. J Neurosci 28(46):12039-51. PubMed: 19005069 MGI: J:142401
Chinnery HR; Humphries T; Clare A; Dixon AE; Howes K; Moran CB; Scott D; Zakrzewski M; Pearlman E; McMenamin PG. 2008. Turnover of bone marrow-derived cells in the irradiated mouse cornea. Immunology 125(4):541-8. PubMed: 18540963 MGI: J:144440
Chinnery HR; McLenachan S; Humphries T; Kezic JM; Chen X; Ruitenberg MJ; McMenamin PG. 2012. Accumulation of murine subretinal macrophages: effects of age, pigmentation and CX3CR1. Neurobiol Aging 33(8):1769-76. PubMed: 21570740 MGI: J:188207
Chinnery HR; Ruitenberg MJ; Plant GW; Pearlman E; Jung S; McMenamin PG. 2007. The chemokine receptor CX3CR1 mediates homing of MHC class II-positive cells to the normal mouse corneal epithelium. Invest Ophthalmol Vis Sci 48(4):1568-74. PubMed: 17389486 MGI: J:123257
Choi HJ; Sun D; Jakobs TC. 2015. Isolation of intact astrocytes from the optic nerve head of adult mice. Exp Eye Res 137:103-10. PubMed: 26093274 MGI: J:230777
Choi I; Kim B; Byun JW; Baik SH; Huh YH; Kim JH; Mook-Jung I; Song WK; Shin JH; Seo H; Suh YH; Jou I; Park SM; Kang HC; Joe EH. 2015. LRRK2 G2019S mutation attenuates microglial motility by inhibiting focal adhesion kinase. Nat Commun 6:8255. PubMed: 26365310 MGI: J:227005
Choi JH; Cheong C; Dandamudi DB; Park CG; Rodriguez A; Mehandru S; Velinzon K; Jung IH; Yoo JY; Oh GT; Steinman RM. 2011. Flt3 Signaling-Dependent Dendritic Cells Protect against Atherosclerosis. Immunity 35(5):819-31. PubMed: 22078798 MGI: J:178831
Chorro L; Sarde A; Li M; Woollard KJ; Chambon P; Malissen B; Kissenpfennig A; Barbaroux JB; Groves R; Geissmann F. 2009. Langerhans cell (LC) proliferation mediates neonatal development, homeostasis, and inflammation-associated expansion of the epidermal LC network. J Exp Med 206(13):3089-100. PubMed: 19995948 MGI: J:155680
Chow A; Lucas D; Hidalgo A; Mendez-Ferrer S; Hashimoto D; Scheiermann C; Battista M; Leboeuf M; Prophete C; van Rooijen N; Tanaka M; Merad M; Frenette PS. 2011. Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche. J Exp Med 208(2):261-71. PubMed: 21282381 MGI: J:176846
Cipriani R; Villa P; Chece G; Lauro C; Paladini A; Micotti E; Perego C; De Simoni MG; Fredholm BB; Eusebi F; Limatola C. 2011. CX3CL1 is neuroprotective in permanent focal cerebral ischemia in rodents. J Neurosci 31(45):16327-35. PubMed: 22072684 MGI: J:191537
Cochain C; Rodero MP; Vilar J; Recalde A; Richart AL; Loinard C; Zouggari Y; Guerin C; Duriez M; Combadiere B; Poupel L; Levy BI; Mallat Z; Combadiere C; Silvestre JS. 2010. Regulation of monocyte subset systemic levels by distinct chemokine receptors controls post-ischaemic neovascularization. Cardiovasc Res 88(1):186-95. PubMed: 20501509 MGI: J:182115
Cohen M; Matcovitch O; David E; Barnett-Itzhaki Z; Keren-Shaul H; Blecher-Gonen R; Jaitin DA; Sica A; Amit I; Schwartz M. 2014. Chronic exposure to TGFbeta1 regulates myeloid cell inflammatory response in an IRF7-dependent manner. EMBO J 33(24):2906-21. PubMed: 25385836 MGI: J:216281
Combadiere C; Feumi C; Raoul W; Keller N; Rodero M; Pezard A; Lavalette S; Houssier M; Jonet L; Picard E; Debre P; Sirinyan M; Deterre P; Ferroukhi T; Cohen SY; Chauvaud D; Jeanny JC; Chemtob S; Behar-Cohen F; Sennlaub F. 2007. CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration. J Clin Invest 117(10):2920-8. PubMed: 17909628 MGI: J:127548
Corcione A; Ferretti E; Bertolotto M; Fais F; Raffaghello L; Gregorio A; Tenca C; Ottonello L; Gambini C; Furtado G; Lira S; Pistoia V. 2009. CX3CR1 is expressed by human B lymphocytes and meditates CX3CL1 driven chemotaxis of tonsil centrocytes. PLoS One 4(12):e8485. PubMed: 20041188 MGI: J:155943
Cronk JC; Derecki NC; Ji E; Xu Y; Lampano AE; Smirnov I; Baker W; Norris GT; Marin I; Coddington N; Wolf Y; Turner SD; Aderem A; Klibanov AL; Harris TH; Jung S; Litvak V; Kipnis J. 2015. Methyl-CpG Binding Protein 2 Regulates Microglia and Macrophage Gene Expression in Response to Inflammatory Stimuli. Immunity 42(4):679-91. PubMed: 25902482 MGI: J:229774
Da Silva N; Cortez-Retamozo V; Reinecker HC; Wildgruber M; Hill E; Brown D; Swirski FK; Pittet MJ; Breton S. 2011. A dense network of dendritic cells populates the murine epididymis. Reproduction 141(5):653-63. PubMed: 21310816 MGI: J:180932
Dagkalis A; Wallace C; Hing B; Liversidge J; Crane IJ. 2009. CX3CR1-deficiency is associated with increased severity of disease in experimental autoimmune uveitis. Immunology 128(1):25-33. PubMed: 19689733 MGI: J:162296
Dal-Secco D; Wang J; Zeng Z; Kolaczkowska E; Wong CH; Petri B; Ransohoff RM; Charo IF; Jenne CN; Kubes P. 2015. A dynamic spectrum of monocytes arising from the in situ reprogramming of CCR2+ monocytes at a site of sterile injury. J Exp Med 212(4):447-56. PubMed: 25800956 MGI: J:222434
Darbousset R; Thomas GM; Mezouar S; Frere C; Bonier R; Mackman N; Renne T; Dignat-George F; Dubois C; Panicot-Dubois L. 2012. Tissue factor-positive neutrophils bind to injured endothelial wall and initiate thrombus formation. Blood 120(10):2133-43. PubMed: 22837532 MGI: J:191325
Daria A; Colombo A; Llovera G; Hampel H; Willem M; Liesz A; Haass C; Tahirovic S. 2017. Young microglia restore amyloid plaque clearance of aged microglia. EMBO J 36(5):583-603. PubMed: 28007893 MGI: J:240183
Daussy C; Faure F; Mayol K; Viel S; Gasteiger G; Charrier E; Bienvenu J; Henry T; Debien E; Hasan UA; Marvel J; Yoh K; Takahashi S; Prinz I; de Bernard S; Buffat L; Walzer T. 2014. T-bet and Eomes instruct the development of two distinct natural killer cell lineages in the liver and in the bone marrow. J Exp Med 211(3):563-77. PubMed: 24516120 MGI: J:210160
Davalos D; Grutzendler J; Yang G; Kim JV; Zuo Y; Jung S; Littman DR; Dustin ML; Gan WB. 2005. ATP mediates rapid microglial response to local brain injury in vivo. Nat Neurosci 8(6):752-8. PubMed: 15895084 MGI: J:156913
David M; Machuca-Gayet I; Kikuta J; Ottewell P; Mima F; Leblanc R; Bonnelye E; Ribeiro J; Holen I; Vales RL; Jurdic P; Chun J; Clezardin P; Ishii M; Peyruchaud O. 2014. Lysophosphatidic acid receptor type 1 (LPA1) plays a functional role in osteoclast differentiation and bone resorption activity. J Biol Chem 289(10):6551-64. PubMed: 24429286 MGI: J:210684
DeFalco T; Bhattacharya I; Williams AV; Sams DM; Capel B. 2014. Yolk-sac-derived macrophages regulate fetal testis vascularization and morphogenesis. Proc Natl Acad Sci U S A 111(23):E2384-93. PubMed: 24912173 MGI: J:211622
Debien E; Mayol K; Biajoux V; Daussy C; De Aguero MG; Taillardet M; Dagany N; Brinza L; Henry T; Dubois B; Kaiserlian D; Marvel J; Balabanian K; Walzer T. 2013. S1PR5 is pivotal for the homeostasis of patrolling monocytes. Eur J Immunol 43(6):1667-75. PubMed: 23519784 MGI: J:198231
Devi S; Li A; Westhorpe CL; Lo CY; Abeynaike LD; Snelgrove SL; Hall P; Ooi JD; Sobey CG; Kitching AR; Hickey MJ. 2013. Multiphoton imaging reveals a new leukocyte recruitment paradigm in the glomerulus. Nat Med 19(1):107-12. PubMed: 23242472 MGI: J:194847
Devi S; Wang Y; Chew WK; Lima R; A-Gonzalez N; Mattar CN; Chong SZ; Schlitzer A; Bakocevic N; Chew S; Keeble JL; Goh CC; Li JL; Evrard M; Malleret B; Larbi A; Renia L; Haniffa M; Tan SM; Chan JK; Balabanian K; Nagasawa T; Bachelerie F; Hidalgo A; GinhouxF; Kubes P; Ng LG. 2013. Neutrophil mobilization via plerixafor-mediated CXCR4 inhibition arises from lung demargination and blockade of neutrophil homing to the bone marrow. J Exp Med 210(11):2321-36. PubMed: 24081949 MGI: J:204051
Dibaj P; Zschuntzsch J; Steffens H; Scheffel J; Goricke B; Weishaupt JH; Le Meur K; Kirchhoff F; Hanisch UK; Schomburg ED; Neusch C. 2012. Influence of methylene blue on microglia-induced inflammation and motor neuron degeneration in the SOD1(G93A) model for ALS. PLoS One 7(8):e43963. PubMed: 22952827 MGI: J:191656
Diehl GE; Longman RS; Zhang JX; Breart B; Galan C; Cuesta A; Schwab SR; Littman DR. 2013. Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX(3)CR1(hi) cells. Nature 494(7435):116-20. PubMed: 23334413 MGI: J:210086
Dissing-Olesen L; LeDue JM; Rungta RL; Hefendehl JK; Choi HB; MacVicar BA. 2014. Activation of neuronal NMDA receptors triggers transient ATP-mediated microglial process outgrowth. J Neurosci 34(32):10511-27. PubMed: 25100586 MGI: J:215582
Donnelly DJ; Longbrake EE; Shawler TM; Kigerl KA; Lai W; Tovar CA; Ransohoff RM; Popovich PG. 2011. Deficient CX3CR1 Signaling Promotes Recovery after Mouse Spinal Cord Injury by Limiting the Recruitment and Activation of Ly6Clo/iNOS+ Macrophages. J Neurosci 31(27):9910-22. PubMed: 21734283 MGI: J:174560
Dworzak J; Renvoise B; Habchi J; Yates EV; Combadiere C; Knowles TP; Dobson CM; Blackstone C; Paulsen O; Murphy PM. 2015. Neuronal Cx3cr1 Deficiency Protects against Amyloid beta-Induced Neurotoxicity. PLoS One 10(6):e0127730. PubMed: 26038823 MGI: J:237718
Eandi CM; Charles Messance H; Augustin S; Dominguez E; Lavalette S; Forster V; Hu SJ; Siquieros L; Craft CM; Sahel JA; Tadayoni R; Paques M; Guillonneau X; Sennlaub F. 2016. Subretinal mononuclear phagocytes induce cone segment loss via IL-1beta. Elife 5:. PubMed: 27438413 MGI: J:235216
Epelman S; Lavine KJ; Beaudin AE; Sojka DK; Carrero JA; Calderon B; Brija T; Gautier EL; Ivanov S; Satpathy AT; Schilling JD; Schwendener R; Sergin I; Razani B; Forsberg EC; Yokoyama WM; Unanue ER; Colonna M; Randolph GJ; Mann DL. 2014. Embryonic and adult-derived resident cardiac macrophages are maintained through distinct mechanisms at steady state and during inflammation. Immunity 40(1):91-104. PubMed: 24439267 MGI: J:209372
Evrard M; Chong SZ; Devi S; Chew WK; Lee B; Poidinger M; Ginhoux F; Tan SM; Ng LG. 2015. Visualization of bone marrow monocyte mobilization using Cx3cr1gfp/+Flt3L-/- reporter mouse by multiphoton intravital microscopy. J Leukoc Biol 97(3):611-9. PubMed: 25516753 MGI: J:220361
Eyo UB; Peng J; Swiatkowski P; Mukherjee A; Bispo A; Wu LJ. 2014. Neuronal hyperactivity recruits microglial processes via neuronal NMDA receptors and microglial P2Y12 receptors after status epilepticus. J Neurosci 34(32):10528-40. PubMed: 25100587 MGI: J:215581
Fainaru O; Woolf E; Lotem J; Yarmus M; Brenner O; Goldenberg D; Negreanu V; Bernstein Y; Levanon D; Jung S; Groner Y. 2004. Runx3 regulates mouse TGF-beta-mediated dendritic cell function and its absence results in airway inflammation. EMBO J 23(4):969-79. PubMed: 14765120 MGI: J:88424
Farache J; Koren I; Milo I; Gurevich I; Kim KW; Zigmond E; Furtado GC; Lira SA; Shakhar G. 2013. Luminal Bacteria Recruit CD103(+) Dendritic Cells into the Intestinal Epithelium to Sample Bacterial Antigens for Presentation. Immunity 38(3):581-95. PubMed: 23395676 MGI: J:194474
Ferjancic S; Gil-Bernabe AM; Hill SA; Allen PD; Richardson P; Sparey T; Savory E; McGuffog J; Muschel RJ. 2013. VCAM-1 and VAP-1 recruit myeloid cells that promote pulmonary metastasis in mice. Blood 121(16):3289-97. PubMed: 23407548 MGI: J:196458
Freria CM; Hall JC; Wei P; Guan Z; McTigue DM; Popovich PG. 2017. Deletion of the Fractalkine Receptor, CX3CR1, Improves Endogenous Repair, Axon Sprouting, and Synaptogenesis after Spinal Cord Injury in Mice. J Neurosci 37(13):3568-3587. PubMed: 28264978 MGI: J:240542
Fuhrmann M; Bittner T; Jung CK; Burgold S; Page RM; Mitteregger G; Haass C; LaFerla FM; Kretzschmar H; Herms J. 2010. Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease. Nat Neurosci 13(4):411-3. PubMed: 20305648 MGI: J:159680
Fumagalli S; Perego C; Ortolano F; De Simoni MG. 2013. CX3CR1 deficiency induces an early protective inflammatory environment in ischemic mice. Glia 61(6):827-42. PubMed: 23440897 MGI: J:194962
Gabanyi I; Muller PA; Feighery L; Oliveira TY; Costa-Pinto FA; Mucida D. 2016. Neuro-immune Interactions Drive Tissue Programming in Intestinal Macrophages. Cell 164(3):378-91. PubMed: 26777404 MGI: J:230661
Gadani SP; Walsh JT; Smirnov I; Zheng J; Kipnis J. 2015. The glia-derived alarmin IL-33 orchestrates the immune response and promotes recovery following CNS injury. Neuron 85(4):703-9. PubMed: 25661185 MGI: J:219889
Gan Y; Liu Q; Wu W; Yin JX; Bai XF; Shen R; Wang Y; Chen J; La Cava A; Poursine-Laurent J; Yokoyama W; Shi FD. 2014. Ischemic neurons recruit natural killer cells that accelerate brain infarction. Proc Natl Acad Sci U S A 111(7):2704-9. PubMed: 24550298 MGI: J:206801
Gao Y; Ottaway N; Schriever SC; Legutko B; Garcia-Caceres C; de la Fuente E; Mergen C; Bour S; Thaler JP; Seeley RJ; Filosa J; Stern JE; Perez-Tilve D; Schwartz MW; Tschop MH; Yi CX. 2014. Hormones and diet, but not body weight, control hypothalamic microglial activity. Glia 62(1):17-25. PubMed: 24166765 MGI: J:203061
Garcia JA; Pino PA; Mizutani M; Cardona SM; Charo IF; Ransohoff RM; Forsthuber TG; Cardona AE. 2013. Regulation of adaptive immunity by the fractalkine receptor during autoimmune inflammation. J Immunol 191(3):1063-72. PubMed: 23817416 MGI: J:205717
Garraud K; Cleret A; Mathieu J; Fiole D; Gauthier Y; Quesnel-Hellmann A; Tournier JN. 2012. Differential role of the interleukin-17 axis and neutrophils in resolution of inhalational anthrax. Infect Immun 80(1):131-42. PubMed: 22025514 MGI: J:178960
Geissmann F; Jung S; Littman DR. 2003. Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity 19(1):71-82. PubMed: 12871640 MGI: J:90912
Ghosh HS; Ceribelli M; Matos I; Lazarovici A; Bussemaker HJ; Lasorella A; Hiebert SW; Liu K; Staudt LM; Reizis B. 2014. ETO family protein Mtg16 regulates the balance of dendritic cell subsets by repressing Id2. J Exp Med 211(8):1623-35. PubMed: 24980046 MGI: J:214727
Gil-Bernabe AM; Ferjancic S; Tlalka M; Zhao L; Allen PD; Im JH; Watson K; Hill SA; Amirkhosravi A; Francis JL; Pollard JW; Ruf W; Muschel RJ. 2012. Recruitment of monocytes/macrophages by tissue factor-mediated coagulation is essential for metastatic cell survival and premetastatic niche establishment in mice. Blood 119(13):3164-75. PubMed: 22327225 MGI: J:182514
Ginhoux F; Liu K; Helft J; Bogunovic M; Greter M; Hashimoto D; Price J; Yin N; Bromberg J; Lira SA; Stanley ER; Nussenzweig M; Merad M. 2009. The origin and development of nonlymphoid tissue CD103+ DCs. J Exp Med 206(13):3115-30. PubMed: 20008528 MGI: J:155668
Gowrishankar S; Yuan P; Wu Y; Schrag M; Paradise S; Grutzendler J; De Camilli P; Ferguson SM. 2015. Massive accumulation of luminal protease-deficient axonal lysosomes at Alzheimer's disease amyloid plaques. Proc Natl Acad Sci U S A 112(28):E3699-708. PubMed: 26124111 MGI: J:223725
Grainger JR; Wohlfert EA; Fuss IJ; Bouladoux N; Askenase MH; Legrand F; Koo LY; Brenchley JM; Fraser ID; Belkaid Y. 2013. Inflammatory monocytes regulate pathologic responses to commensals during acute gastrointestinal infection. Nat Med 19(6):713-21. PubMed: 23708291 MGI: J:198666
Gregory AD; Capoccia BJ; Woloszynek JR; Link DC. 2010. Systemic levels of G-CSF and interleukin-6 determine the angiogenic potential of bone marrow resident monocytes. J Leukoc Biol 88(1):123-31. PubMed: 20354107 MGI: J:162446
Grier BD; Belluscio L; Cheetham CE. 2016. Olfactory Sensory Activity Modulates Microglial-Neuronal Interactions during Dopaminergic Cell Loss in the Olfactory Bulb. Front Cell Neurosci 10:178. PubMed: 27471450 MGI: J:240351
Grutzendler J; Murikinati S; Hiner B; Ji L; Lam CK; Yoo T; Gupta S; Hafler BP; Adelman RA; Yuan P; Rodriguez G. 2014. Angiophagy prevents early embolus washout but recanalizes microvessels through embolus extravasation. Sci Transl Med 6(226):226ra31. PubMed: 24598589 MGI: J:213666
Gu N; Peng J; Murugan M; Wang X; Eyo UB; Sun D; Ren Y; DiCicco-Bloom E; Young W; Dong H; Wu LJ. 2016. Spinal Microgliosis Due to Resident Microglial Proliferation Is Required for Pain Hypersensitivity after Peripheral Nerve Injury. Cell Rep 16(3):605-14. PubMed: 27373153 MGI: J:238587
Guerrero AD; Dong MB; Zhao Y; Lau-Kilby A; Tarbell KV. 2014. Interleukin-2-mediated inhibition of dendritic cell development correlates with decreased CD135 expression and increased monocyte/macrophage precursors. Immunology 143(4):640-50. PubMed: 24954893 MGI: J:220050
Gundra UM; Girgis NM; Ruckerl D; Jenkins S; Ward LN; Kurtz ZD; Wiens KE; Tang MS; Basu-Roy U; Mansukhani A; Allen JE; Loke P. 2014. Alternatively activated macrophages derived from monocytes and tissue macrophages are phenotypically and functionally distinct. Blood 123(20):e110-22. PubMed: 24695852 MGI: J:212404
Gyoneva S; Swanger SA; Zhang J; Weinshenker D; Traynelis SF. 2016. Altered motility of plaque-associated microglia in a model of Alzheimer's disease. Neuroscience 330:410-20. PubMed: 27288150 MGI: J:236495
Hadis U; Wahl B; Schulz O; Hardtke-Wolenski M; Schippers A; Wagner N; Muller W; Sparwasser T; Forster R; Pabst O. 2011. Intestinal Tolerance Requires Gut Homing and Expansion of FoxP3(+) Regulatory T Cells in the Lamina Propria. Immunity 34(2):237-46. PubMed: 21333554 MGI: J:168976
Hagemeyer N; Kierdorf K; Frenzel K; Xue J; Ringelhan M; Abdullah Z; Godin I; Wieghofer P; Costa Jordao MJ; Ulas T; Yorgancioglu G; Rosenbauer F; Knolle PA; Heikenwalder M; Schultze JL; Prinz M. 2016. Transcriptome-based profiling of yolk sac-derived macrophages reveals a role for Irf8 in macrophage maturation. EMBO J 35(16):1730-44. PubMed: 27412700 MGI: J:235152
Hammond MD; Taylor RA; Mullen MT; Ai Y; Aguila HL; Mack M; Kasner SE; McCullough LD; Sansing LH. 2014. CCR2+ Ly6C(hi) inflammatory monocyte recruitment exacerbates acute disability following intracerebral hemorrhage. J Neurosci 34(11):3901-9. PubMed: 24623768 MGI: J:209603
Hamon P; Loyher PL; Baudesson de Chanville C; Licata F; Combadiere C; Boissonnas A. 2017. CX3CR1-dependent endothelial margination modulates Ly6Chigh monocyte systemic deployment upon inflammation in mice. Blood 129(10):1296-1307. PubMed: 28011675 MGI: J:240107
Hapfelmeier S; Muller AJ; Stecher B; Kaiser P; Barthel M; Endt K; Eberhard M; Robbiani R; Jacobi CA; Heikenwalder M; Kirschning C; Jung S; Stallmach T; Kremer M; Hardt WD. 2008. Microbe sampling by mucosal dendritic cells is a discrete, MyD88-independent step in DeltainvG S. Typhimurium colitis. J Exp Med 205(2):437-50. PubMed: 18268033 MGI: J:132107
Haynes SE; Hollopeter G; Yang G; Kurpius D; Dailey ME; Gan WB; Julius D. 2006. The P2Y(12) receptor regulates microglial activation by extracellular nucleotides. Nat Neurosci 9(12):1512-9. PubMed: 17115040 MGI: J:116110
Hoeffel G; Wang Y; Greter M; See P; Teo P; Malleret B; Leboeuf M; Low D; Oller G; Almeida F; Choy SH; Grisotto M; Renia L; Conway SJ; Stanley ER; Chan JK; Ng LG; Samokhvalov IM; Merad M; Ginhoux F. 2012. Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac-derived macrophages. J Exp Med 209(6):1167-81. PubMed: 22565823 MGI: J:189052
Hohl TM; Rivera A; Lipuma L; Gallegos A; Shi C; Mack M; Pamer EG. 2009. Inflammatory monocytes facilitate adaptive CD4 T cell responses during respiratory fungal infection. Cell Host Microbe 6(5):470-81. PubMed: 19917501 MGI: J:214063
Holt MP; Cheng L; Ju C. 2008. Identification and characterization of infiltrating macrophages in acetaminophen-induced liver injury. J Leukoc Biol 84(6):1410-21. PubMed: 18713872 MGI: J:142295
Hoshiko M; Arnoux I; Avignone E; Yamamoto N; Audinat E. 2012. Deficiency of the microglial receptor CX3CR1 impairs postnatal functional development of thalamocortical synapses in the barrel cortex. J Neurosci 32(43):15106-11. PubMed: 23100431 MGI: J:192174
Hoshino A; Ueha S; Hanada S; Imai T; Ito M; Yamamoto K; Matsushima K; Yamaguchi A; Iimura T. 2013. Roles of chemokine receptor CX3CR1 in maintaining murine bone homeostasis through the regulation of both osteoblasts and osteoclasts. J Cell Sci 126(Pt 4):1032-45. PubMed: 23264747 MGI: J:200221
Hu SJ; Calippe B; Lavalette S; Roubeix C; Montassar F; Housset M; Levy O; Delarasse C; Paques M; Sahel JA; Sennlaub F; Guillonneau X. 2015. Upregulation of P2RX7 in Cx3cr1-Deficient Mononuclear Phagocytes Leads to Increased Interleukin-1beta Secretion and Photoreceptor Neurodegeneration. J Neurosci 35(18):6987-96. PubMed: 25948251 MGI: J:221649
Huang D; Shi FD; Jung S; Pien GC; Wang J; Salazar-Mather TP; He TT; Weaver JT; Ljunggren HG; Biron CA; Littman DR; Ransohoff RM. 2006. The neuronal chemokine CX3CL1/fractalkine selectively recruits NK cells that modify experimental autoimmune encephalomyelitis within the central nervous system. FASEB J 20(7):896-905. PubMed: 16675847 MGI: J:129712
Huang D; Wujek J; Kidd G; He TT; Cardona A; Sasse ME; Stein EJ; Kish J; Tani M; Charo IF; Proudfoot AE; Rollins BJ; Handel T; Ransohoff RM. 2005. Chronic expression of monocyte chemoattractant protein-1 in the central nervous system causes delayed encephalopathy and impaired microglial function in mice. FASEB J 19(7):761-72. PubMed: 15857890 MGI: J:134548
Hyun YM; Sumagin R; Sarangi PP; Lomakina E; Overstreet MG; Baker CM; Fowell DJ; Waugh RE; Sarelius IH; Kim M. 2012. Uropod elongation is a common final step in leukocyte extravasation through inflamed vessels. J Exp Med :. PubMed: 22711877 MGI: J:184820
Imhof BA; Jemelin S; Ballet R; Vesin C; Schapira M; Karaca M; Emre Y. 2016. CCN1/CYR61-mediated meticulous patrolling by Ly6Clow monocytes fuels vascular inflammation. Proc Natl Acad Sci U S A 113(33):E4847-56. PubMed: 27482114 MGI: J:235618
Iqbal AJ; McNeill E; Kapellos TS; Regan-Komito D; Norman S; Burd S; Smart N; Machemer DE; Stylianou E; McShane H; Channon KM; Chawla A; Greaves DR. 2014. Human CD68 promoter GFP transgenic mice allow analysis of monocyte to macrophage differentiation in vivo. Blood 124(15):e33-44. PubMed: 25030063 MGI: J:215825
Ishifune C; Maruyama S; Sasaki Y; Yagita H; Hozumi K; Tomita T; Kishihara K; Yasutomo K. 2014. Differentiation of CD11c+CX3CR1+ cells in the small intestine requires Notch signaling. Proc Natl Acad Sci U S A 111(16):5986-91. PubMed: 24711412 MGI: J:208857
Ishii M; Egen JG; Klauschen F; Meier-Schellersheim M; Saeki Y; Vacher J; Proia RL; Germain RN. 2009. Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis. Nature 458(7237):524-8. PubMed: 19204730 MGI: J:147106
Ishii M; Kikuta J; Shimazu Y; Meier-Schellersheim M; Germain RN. 2010. Chemorepulsion by blood S1P regulates osteoclast precursor mobilization and bone remodeling in vivo. J Exp Med 207(13):2793-8. PubMed: 21135136 MGI: J:176951
Ivanov S; Scallan JP; Kim KW; Werth K; Johnson MW; Saunders BT; Wang PL; Kuan EL; Straub AC; Ouhachi M; Weinstein EG; Williams JW; Briseno C; Colonna M; Isakson BE; Gautier EL; Forster R; Davis MJ; Zinselmeyer BH; Randolph GJ. 2016. CCR7 and IRF4-dependent dendritic cells regulate lymphatic collecting vessel permeability. J Clin Invest 126(4):1581-91. PubMed: 26999610 MGI: J:234708
Izhak L; Wildbaum G; Jung S; Stein A; Shaked Y; Karin N. 2012. Dissecting the autocrine and paracrine roles of the CCR2-CCL2 axis in tumor survival and angiogenesis. PLoS One 7(1):e28305. PubMed: 22279523 MGI: J:184239
Jacquelin S; Licata F; Dorgham K; Hermand P; Poupel L; Guyon E; Deterre P; Hume DA; Combadiere C; Boissonnas A. 2013. CX3CR1 reduces Ly6Chigh-monocyte motility within and release from the bone marrow after chemotherapy in mice. Blood 122(5):674-83. PubMed: 23775714 MGI: J:202291
Jakubzick C; Gautier EL; Gibbings SL; Sojka DK; Schlitzer A; Johnson TE; Ivanov S; Duan Q; Bala S; Condon T; van Rooijen N; Grainger JR; Belkaid Y; Ma'ayan A; Riches DW; Yokoyama WM; Ginhoux F; Henson PM; Randolph GJ. 2013. Minimal differentiation of classical monocytes as they survey steady-state tissues and transport antigen to lymph nodes. Immunity 39(3):599-610. PubMed: 24012416 MGI: J:208214
Jaworski T; Lechat B; Demedts D; Gielis L; Devijver H; Borghgraef P; Duimel H; Verheyen F; Kugler S; Van Leuven F. 2011. Dendritic degeneration, neurovascular defects, and inflammation precede neuronal loss in a mouse model for tau-mediated neurodegeneration. Am J Pathol 179(4):2001-15. PubMed: 21839061 MGI: J:176300
Jin LW; Horiuchi M; Wulff H; Liu XB; Cortopassi GA; Erickson JD; Maezawa I. 2015. Dysregulation of glutamine transporter SNAT1 in Rett syndrome microglia: a mechanism for mitochondrial dysfunction and neurotoxicity. J Neurosci 35(6):2516-29. PubMed: 25673846 MGI: J:219878
Joly S; Francke M; Ulbricht E; Beck S; Seeliger M; Hirrlinger P; Hirrlinger J; Lang KS; Zinkernagel M; Odermatt B; Samardzija M; Reichenbach A; Grimm C; Reme CE. 2009. Cooperative phagocytes: resident microglia and bone marrow immigrants remove dead photoreceptors in retinal lesions. Am J Pathol 174(6):2310-23. PubMed: 19435787 MGI: J:148765
Jung CK; Keppler K; Steinbach S; Blazquez-Llorca L; Herms J. 2015. Fibrillar amyloid plaque formation precedes microglial activation. PLoS One 10(3):e0119768. PubMed: 25799372 MGI: J:232972
Kabra DG; Pfuhlmann K; Garcia-Caceres C; Schriever SC; Casquero Garcia V; Kebede AF; Fuente-Martin E; Trivedi C; Heppner K; Uhlenhaut NH; Legutko B; Kabra UD; Gao Y; Yi CX; Quarta C; Clemmensen C; Finan B; Muller TD; Meyer CW; Paez-Pereda M; Stemmer K; Woods SC; Perez-Tilve D; Schneider R; Olson EN; Tschop MH; Pfluger PT. 2016. Hypothalamic leptin action is mediated by histone deacetylase 5. Nat Commun 7:10782. PubMed: 26923837 MGI: J:234826
Kaiser P; Regoes RR; Dolowschiak T; Wotzka SY; Lengefeld J; Slack E; Grant AJ; Ackermann M; Hardt WD. 2014. Cecum lymph node dendritic cells harbor slow-growing bacteria phenotypically tolerant to antibiotic treatment. PLoS Biol 12(2):e1001793. PubMed: 24558351 MGI: J:208411
Kang SJ; Liang HE; Reizis B; Locksley RM. 2008. Regulation of hierarchical clustering and activation of innate immune cells by dendritic cells. Immunity 29(5):819-33. PubMed: 19006696 MGI: J:142395
Kaur T; Zamani D; Tong L; Rubel EW; Ohlemiller KK; Hirose K; Warchol ME. 2015. Fractalkine Signaling Regulates Macrophage Recruitment into the Cochlea and Promotes the Survival of Spiral Ganglion Neurons after Selective Hair Cell Lesion. J Neurosci 35(45):15050-61. PubMed: 26558776 MGI: J:227699
Kawakami T; Lichtnekert J; Thompson LJ; Karna P; Bouabe H; Hohl TM; Heinecke JW; Ziegler SF; Nelson PJ; Duffield JS. 2013. Resident renal mononuclear phagocytes comprise five discrete populations with distinct phenotypes and functions. J Immunol 191(6):3358-72. PubMed: 23956422 MGI: J:205879
Kayama H; Ueda Y; Sawa Y; Jeon SG; Ma JS; Okumura R; Kubo A; Ishii M; Okazaki T; Murakami M; Yamamoto M; Yagita H; Takeda K. 2012. Intestinal CX3C chemokine receptor 1high (CX3CR1high) myeloid cells prevent T-cell-dependent colitis. Proc Natl Acad Sci U S A 109(13):5010-5. PubMed: 22403066 MGI: J:182225
Kezic J; McMenamin PG. 2008. Differential turnover rates of monocyte-derived cells in varied ocular tissue microenvironments. J Leukoc Biol 84(3):721-9. PubMed: 18577714 MGI: J:138301
Kezic J; McMenamin PG. 2010. The monocyte chemokine receptor CX3CR1 does not play a significant role in the pathogenesis of experimental autoimmune uveoretinitis. Invest Ophthalmol Vis Sci 51(10):5121-7. PubMed: 20463325 MGI: J:171405
Kezic J; Xu H; Chinnery HR; Murphy CC; McMenamin PG. 2008. Retinal microglia and uveal tract dendritic cells and macrophages are not CX3CR1 dependent in their recruitment and distribution in the young mouse eye. Invest Ophthalmol Vis Sci 49(4):1599-608. PubMed: 18385080 MGI: J:136154
Kezic JM; McMenamin PG. 2013. The effects of CX3CR1 deficiency and irradiation on the homing of monocyte-derived cell populations in the mouse eye. PLoS One 8(7):e68570. PubMed: 23844223 MGI: J:204298
Khan MA; Schultz S; Othman A; Fleming T; Lebron-Galan R; Rades D; Clemente D; Nawroth PP; Schwaninger M. 2016. Hyperglycemia in Stroke Impairs Polarization of Monocytes/Macrophages to a Protective Noninflammatory Cell Type. J Neurosci 36(36):9313-25. PubMed: 27605608 MGI: J:235206
Khandoga AG; Khandoga A; Reichel CA; Bihari P; Rehberg M; Krombach F. 2009. In vivo imaging and quantitative analysis of leukocyte directional migration and polarization in inflamed tissue. PLoS One 4(3):e4693. PubMed: 19259262 MGI: J:237974
Kierdorf K; Erny D; Goldmann T; Sander V; Schulz C; Perdiguero EG; Wieghofer P; Heinrich A; Riemke P; Holscher C; Muller DN; Luckow B; Brocker T; Debowski K; Fritz G; Opdenakker G; Diefenbach A; Biber K; Heikenwalder M; Geissmann F; Rosenbauer F; Prinz M. 2013. Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways. Nat Neurosci 16(3):273-80. PubMed: 23334579 MGI: J:197476
Kikuta J; Kawamura S; Okiji F; Shirazaki M; Sakai S; Saito H; Ishii M. 2013. Sphingosine-1-phosphate-mediated osteoclast precursor monocyte migration is a critical point of control in antibone-resorptive action of active vitamin D. Proc Natl Acad Sci U S A 110(17):7009-13. PubMed: 23569273 MGI: J:196150
Kim D; You B; Jo EK; Han SK; Simon MI; Lee SJ. 2010. NADPH oxidase 2-derived reactive oxygen species in spinal cord microglia contribute to peripheral nerve injury-induced neuropathic pain. Proc Natl Acad Sci U S A 107(33):14851-6. PubMed: 20679217 MGI: J:163708
Kim I; Mlsna LM; Yoon S; Le B; Yu S; Xu D; Koh S. 2015. A postnatal peak in microglial development in the mouse hippocampus is correlated with heightened sensitivity to seizure triggers. Brain Behav 5(12):e00403. PubMed: 26807334 MGI: J:240091
Kim JV; Dustin ML. 2006. Innate response to focal necrotic injury inside the blood-brain barrier. J Immunol 177(8):5269-77. PubMed: 17015712 MGI: J:139445
Kim KW; Vallon-Eberhard A; Zigmond E; Farache J; Shezen E; Shakhar G; Ludwig A; Lira SA; Jung S. 2011. In vivo structure/function and expression analysis of the CX3C chemokine fractalkine. Blood 118(22):e156-67. PubMed: 21951685 MGI: J:178874
Kim KW; Williams JW; Wang YT; Ivanov S; Gilfillan S; Colonna M; Virgin HW; Gautier EL; Randolph GJ. 2016. MHC II+ resident peritoneal and pleural macrophages rely on IRF4 for development from circulating monocytes. J Exp Med 213(10):1951-9. PubMed: 27551152 MGI: J:237036
Kim SH; Yang IY; Kim J; Lee KY; Jang YS. 2015. Antimicrobial peptide LL-37 promotes antigen-specific immune responses in mice by enhancing Th17-skewed mucosal and systemic immunities. Eur J Immunol 45(5):1402-13. PubMed: 25655317 MGI: J:229786
Koenigsknecht-Talboo J; Meyer-Luehmann M; Parsadanian M; Garcia-Alloza M; Finn MB; Hyman BT; Bacskai BJ; Holtzman DM. 2008. Rapid microglial response around amyloid pathology after systemic anti-Abeta antibody administration in PDAPP mice. J Neurosci 28(52):14156-64. PubMed: 19109498 MGI: J:143879
Kohno H; Maeda T; Perusek L; Pearlman E; Maeda A. 2014. CCL3 production by microglial cells modulates disease severity in murine models of retinal degeneration. J Immunol 192(8):3816-27. PubMed: 24639355 MGI: J:210001
Krabbe G; Halle A; Matyash V; Rinnenthal JL; Eom GD; Bernhardt U; Miller KR; Prokop S; Kettenmann H; Heppner FL. 2013. Functional impairment of microglia coincides with Beta-amyloid deposition in mice with Alzheimer-like pathology. PLoS One 8(4):e60921. PubMed: 23577177 MGI: J:199932
Kumar A; Zhao L; Fariss RN; McMenamin PG; Wong WT. 2014. Vascular associations and dynamic process motility in perivascular myeloid cells of the mouse choroid: implications for function and senescent change. Invest Ophthalmol Vis Sci 55(3):1787-96. PubMed: 24458147 MGI: J:229289
Kumar AH; Martin K; Turner EC; Buneker CK; Dorgham K; Deterre P; Caplice NM. 2013. Role of CX3CR1 receptor in monocyte/macrophage driven neovascularization. PLoS One 8(2):e57230. PubMed: 23437346 MGI: J:197189
Kurihara T; Westenskow PD; Krohne TU; Aguilar E; Johnson RS; Friedlander M. 2011. Astrocyte pVHL and HIF-alpha isoforms are required for embryonic-to-adult vascular transition in the eye. J Cell Biol 195(4):689-701. PubMed: 22084310 MGI: J:178823
Kwan W; Trager U; Davalos D; Chou A; Bouchard J; Andre R; Miller A; Weiss A; Giorgini F; Cheah C; Moller T; Stella N; Akassoglou K; Tabrizi SJ; Muchowski PJ. 2012. Mutant huntingtin impairs immune cell migration in Huntington disease. J Clin Invest 122(12):4737-47. PubMed: 23160193 MGI: J:193974
Laffont S; Siddiqui KR; Powrie F. 2010. Intestinal inflammation abrogates the tolerogenic properties of MLN CD103(+) dendritic cells. Eur J Immunol 40(7):1877-1883. PubMed: 20432234 MGI: J:161863
Lammermann T; Afonso PV; Angermann BR; Wang JM; Kastenmuller W; Parent CA; Germain RN. 2013. Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo. Nature 498(7454):371-5. PubMed: 23708969 MGI: J:198733
Landsman L; Bar-On L; Zernecke A; Kim KW; Krauthgamer R; Shagdarsuren E; Lira SA; Weissman IL; Weber C; Jung S. 2009. CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival. Blood 113(4):963-72. PubMed: 18971423 MGI: J:145036
Lantier L; Lacroix-Lamande S; Potiron L; Metton C; Drouet F; Guesdon W; Gnahoui-David A; Le Vern Y; Deriaud E; Fenis A; Rabot S; Descamps A; Werts C; Laurent F. 2013. Intestinal CD103+ dendritic cells are key players in the innate immune control of Cryptosporidium parvum infection in neonatal mice. PLoS Pathog 9(12):e1003801. PubMed: 24367259 MGI: J:238037
Lau CM; Nish SA; Yogev N; Waisman A; Reiner SL; Reizis B. 2016. Leukemia-associated activating mutation of Flt3 expands dendritic cells and alters T cell responses. J Exp Med 213(3):415-31. PubMed: 26903243 MGI: J:232928
Lau-Kilby AW; Kretz CC; Pechhold S; Price JD; Dorta S; Ramos H; Trinchieri G; Tarbell KV. 2011. Interleukin-2 inhibits FMS-like tyrosine kinase 3 receptor ligand (flt3L)-dependent development and function of conventional and plasmacytoid dendritic cells. Proc Natl Acad Sci U S A 108(6):2408-13. PubMed: 21262836 MGI: J:169098
Lauro C; Di Angelantonio S; Cipriani R; Sobrero F; Antonilli L; Brusadin V; Ragozzino D; Limatola C. 2008. Activity of adenosine receptors type 1 Is required for CX3CL1-mediated neuroprotection and neuromodulation in hippocampal neurons. J Immunol 180(11):7590-6. PubMed: 18490761 MGI: J:136344
Lee HS; Hos D; Blanco T; Bock F; Reyes NJ; Mathew R; Cursiefen C; Dana R; Saban DR. 2015. Involvement of corneal lymphangiogenesis in a mouse model of allergic eye disease. Invest Ophthalmol Vis Sci 56(5):3140-8. PubMed: 26024097 MGI: J:230962
Lee S; Varvel NH; Konerth ME; Xu G; Cardona AE; Ransohoff RM; Lamb BT. 2010. CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models. Am J Pathol 177(5):2549-62. PubMed: 20864679 MGI: J:166257
Lee S; Xu G; Jay TR; Bhatta S; Kim KW; Jung S; Landreth GE; Ransohoff RM; Lamb BT. 2014. Opposing effects of membrane-anchored CX3CL1 on amyloid and tau pathologies via the p38 MAPK pathway. J Neurosci 34(37):12538-46. PubMed: 25209291 MGI: J:216289
Lee WY; Moriarty TJ; Wong CH; Zhou H; Strieter RM; van Rooijen N; Chaconas G; Kubes P. 2010. An intravascular immune response to Borrelia burgdorferi involves Kupffer cells and iNKT cells. Nat Immunol 11(4):295-302. PubMed: 20228796 MGI: J:158972
Lee YS; Morinaga H; Kim JJ; Lagakos W; Taylor S; Keshwani M; Perkins G; Dong H; Kayali AG; Sweet IR; Olefsky J. 2013. The fractalkine/CX3CR1 system regulates beta cell function and insulin secretion. Cell 153(2):413-25. PubMed: 23582329 MGI: J:197365
Lerchenberger M; Uhl B; Stark K; Zuchtriegel G; Eckart A; Miller M; Puhr-Westerheide D; Praetner M; Rehberg M; Khandoga AG; Lauber K; Massberg S; Krombach F; Reichel CA. 2013. Matrix metalloproteinases modulate ameboid-like migration of neutrophils through inflamed interstitial tissue. Blood 122(5):770-80. PubMed: 23757732 MGI: J:201769
Leuschner F; Panizzi P; Chico-Calero I; Lee WW; Ueno T; Cortez-Retamozo V; Waterman P; Gorbatov R; Marinelli B; Iwamoto Y; Chudnovskiy A; Figueiredo JL; Sosnovik DE; Pittet MJ; Swirski FK; Weissleder R; Nahrendorf M. 2010. Angiotensin-converting enzyme inhibition prevents the release of monocytes from their splenic reservoir in mice with myocardial infarction. Circ Res 107(11):1364-73. PubMed: 20930148 MGI: J:178180
Levy O; Calippe B; Lavalette S; Hu SJ; Raoul W; Dominguez E; Housset M; Paques M; Sahel JA; Bemelmans AP; Combadiere C; Guillonneau X; Sennlaub F. 2015. Apolipoprotein E promotes subretinal mononuclear phagocyte survival and chronic inflammation in age-related macular degeneration. EMBO Mol Med 7(2):211-26. PubMed: 25604058 MGI: J:232682
Lewis CA; Solomon JN; Rossi FM; Krieger C. 2009. Bone marrow-derived cells in the central nervous system of a mouse model of amyotrophic lateral sclerosis are associated with blood vessels and express CX(3)CR1. Glia 57(13):1410-9. PubMed: 19243075 MGI: J:156201
Li L; Huang L; Sung SS; Vergis AL; Rosin DL; Rose CE Jr; Lobo PI; Okusa MD. 2008. The chemokine receptors CCR2 and CX3CR1 mediate monocyte/macrophage trafficking in kidney ischemia-reperfusion injury. Kidney Int 74(12):1526-37. PubMed: 18843253 MGI: J:162714
Liang KJ; Lee JE; Wang YD; Ma W; Fontainhas AM; Fariss RN; Wong WT. 2009. Regulation of dynamic behavior of retinal microglia by CX3CR1 signaling. Invest Ophthalmol Vis Sci 50(9):4444-51. PubMed: 19443728 MGI: J:154542
Lin KL; Suzuki Y; Nakano H; Ramsburg E; Gunn MD. 2008. CCR2+ monocyte-derived dendritic cells and exudate macrophages produce influenza-induced pulmonary immune pathology and mortality. J Immunol 180(4):2562-72. PubMed: 18250467 MGI: J:131979
Lionakis MS; Swamydas M; Fischer BG; Plantinga TS; Johnson MD; Jaeger M; Green NM; Masedunskas A; Weigert R; Mikelis C; Wan W; Lee CC; Lim JK; Rivollier A; Yang JC; Laird GM; Wheeler RT; Alexander BD; Perfect JR; Gao JL; Kullberg BJ; Netea MG; Murphy PM. 2013. CX3CR1-dependent renal macrophage survival promotes Candida control and host survival. J Clin Invest 123(12):5035-51. PubMed: 24177428 MGI: J:207701
Liu J; Copland DA; Horie S; Wu WK; Chen M; Xu Y; Paul Morgan B; Mack M; Xu H; Nicholson LB; Dick AD. 2013. Myeloid cells expressing VEGF and arginase-1 following uptake of damaged retinal pigment epithelium suggests potential mechanism that drives the onset of choroidal angiogenesis in mice. PLoS One 8(8):e72935. PubMed: 23977372 MGI: J:206423
Liu J; Tian D; Murugan M; Eyo UB; Dreyfus CF; Wang W; Wu LJ. 2015. Microglial Hv1 proton channel promotes cuprizone-induced demyelination through oxidative damage. J Neurochem 135(2):347-56. PubMed: 26173779 MGI: J:226078
Liu K; Victora GD; Schwickert TA; Guermonprez P; Meredith MM; Yao K; Chu FF; Randolph GJ; Rudensky AY; Nussenzweig M. 2009. In Vivo Analysis of Dendritic Cell Development and Homeostasis. Science :. PubMed: 19286519 MGI: J:147362
Liu P; Patil S; Rojas M; Fong AM; Smyth SS; Patel DD. 2006. CX3CR1 deficiency confers protection from intimal hyperplasia after arterial injury. Arterioscler Thromb Vasc Biol 26(9):2056-62. PubMed: 16809547 MGI: J:124722
Liu S; Li ZW; Weinreb RN; Xu G; Lindsey JD; Ye C; Yung WH; Pang CP; Lam DS; Leung CK. 2012. Tracking retinal microgliosis in models of retinal ganglion cell damage. Invest Ophthalmol Vis Sci 53(10):6254-62. PubMed: 22879415 MGI: J:213967
Liu Y; Zhou LJ; Wang J; Li D; Ren WJ; Peng J; Wei X; Xu T; Xin WJ; Pang RP; Li YY; Qin ZH; Murugan M; Mattson MP; Wu LJ; Liu XG. 2017. TNF-alpha Differentially Regulates Synaptic Plasticity in the Hippocampus and Spinal Cord by Microglia-Dependent Mechanisms after Peripheral Nerve Injury. J Neurosci 37(4):871-881. PubMed: 28123022 MGI: J:239153
Liu Z; Condello C; Schain A; Harb R; Grutzendler J. 2010. CX3CR1 in microglia regulates brain amyloid deposition through selective protofibrillar amyloid-beta phagocytosis. J Neurosci 30(50):17091-101. PubMed: 21159979 MGI: J:167723
Lloyd-Burton SM; York EM; Anwar MA; Vincent AJ; Roskams AJ. 2013. SPARC regulates microgliosis and functional recovery following cortical ischemia. J Neurosci 33(10):4468-81. PubMed: 23467362 MGI: J:196279
London A; Itskovich E; Benhar I; Kalchenko V; Mack M; Jung S; Schwartz M. 2011. Neuroprotection and progenitor cell renewal in the injured adult murine retina requires healing monocyte-derived macrophages. J Exp Med 208(1):23-39. PubMed: 21220455 MGI: J:176855
Lou N; Takano T; Pei Y; Xavier AL; Goldman SA; Nedergaard M. 2016. Purinergic receptor P2RY12-dependent microglial closure of the injured blood-brain barrier. Proc Natl Acad Sci U S A 113(4):1074-9. PubMed: 26755608 MGI: J:229920
Luche H; Ardouin L; Teo P; See P; Henri S; Merad M; Ginhoux F; Malissen B. 2011. The earliest intrathymic precursors of CD8alpha(+) thymic dendritic cells correspond to myeloid-type double-negative 1c cells. Eur J Immunol 41(8):2165-75. PubMed: 21630253 MGI: J:176820
Lyszkiewicz M; Witzlau K; Pommerencke J; Krueger A. 2011. Chemokine receptor CX3CR1 promotes dendritic cell development under steady-state conditions. Eur J Immunol 41(5):1256-65. PubMed: 21425158 MGI: J:175414
Lyszkiewicz M; Zietara N; Fohse L; Puchalka J; Diestelhorst J; Witzlau K; Prinz I; Schambach A; Krueger A. 2015. Limited niche availability suppresses murine intrathymic dendritic-cell development from noncommitted progenitors. Blood 125(3):457-64. PubMed: 25411428 MGI: J:221207
Ma B; Xu L; Pan X; Sun L; Ding J; Xie C; Koliatsos VE; Cai H. 2016. LRRK2 modulates microglial activity through regulation of chemokine (C-X3-C) receptor 1 -mediated signalling pathways. Hum Mol Genet 25(16):3515-3523. PubMed: 27378696 MGI: J:237862
Ma W; Coon S; Zhao L; Fariss RN; Wong WT. 2013. A2E accumulation influences retinal microglial activation and complement regulation. Neurobiol Aging 34(3):943-60. PubMed: 22819137 MGI: J:194430
Madsen DH; Leonard D; Masedunskas A; Moyer A; Jurgensen HJ; Peters DE; Amornphimoltham P; Selvaraj A; Yamada SS; Brenner DA; Burgdorf S; Engelholm LH; Behrendt N; Holmbeck K; Weigert R; Bugge TH. 2013. M2-like macrophages are responsible for collagen degradation through a mannose receptor-mediated pathway. J Cell Biol 202(6):951-66. PubMed: 24019537 MGI: J:201738
Maeda A; Palczewska G; Golczak M; Kohno H; Dong Z; Maeda T; Palczewski K. 2014. Two-photon microscopy reveals early rod photoreceptor cell damage in light-exposed mutant mice. Proc Natl Acad Sci U S A 111(14):E1428-37. PubMed: 24706832 MGI: J:208625
Mass E; Ballesteros I; Farlik M; Halbritter F; Gunther P; Crozet L; Jacome-Galarza CE; Handler K; Klughammer J; Kobayashi Y; Gomez-Perdiguero E; Schultze JL; Beyer M; Bock C; Geissmann F. 2016. Specification of tissue-resident macrophages during organogenesis. Science 353(6304):. PubMed: 27492475 MGI: J:235615
Masse GX; Corcuff E; Strick-Marchand H; Guy-Grand D; Tafuri-Bladt A; Albert ML; Lantz O; Di Santo JP. 2007. Gamma c cytokines condition the progressive differentiation of CD4+ T cells. Proc Natl Acad Sci U S A 104(39):15442-7. PubMed: 17855567 MGI: J:125207
Massena S; Christoffersson G; Hjertstrom E; Zcharia E; Vlodavsky I; Ausmees N; Rolny C; Li JP; Phillipson M. 2010. A chemotactic gradient sequestered on endothelial heparan sulfate induces directional intraluminal crawling of neutrophils. Blood 116(11):1924-31. PubMed: 20530797 MGI: J:164516
Massena S; Christoffersson G; Vagesjo E; Seignez C; Gustafsson K; Binet F; Herrera Hidalgo C; Giraud A; Lomei J; Westrom S; Shibuya M; Claesson-Welsh L; Gerwins P; Welsh M; Kreuger J; Phillipson M. 2015. Identification and characterization of VEGF-A-responsive neutrophils expressing CD49d, VEGFR1, and CXCR4 in mice and humans. Blood 126(17):2016-26. PubMed: 26286848 MGI: J:230680
McAvoy EF; McDonald B; Parsons SA; Wong CH; Landmann R; Kubes P. 2011. The role of CD14 in neutrophil recruitment within the liver microcirculation during endotoxemia. J Immunol 186(4):2592-601. PubMed: 21217012 MGI: J:169174
McComb JG; Ranganathan M; Liu XH; Pilewski JM; Ray P; Watkins SC; Choi AM; Lee JS. 2008. CX3CL1 up-regulation is associated with recruitment of CX3CR1+ mononuclear phagocytes and T lymphocytes in the lungs during cigarette smoke-induced emphysema. Am J Pathol 173(4):949-61. PubMed: 18772344 MGI: J:139658
McDole JR; Wheeler LW; McDonald KG; Wang B; Konjufca V; Knoop KA; Newberry RD; Miller MJ. 2012. Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine. Nature 483(7389):345-9. PubMed: 22422267 MGI: J:182576
Medina-Contreras O; Geem D; Laur O; Williams IR; Lira SA; Nusrat A; Parkos CA; Denning TL. 2011. CX3CR1 regulates intestinal macrophage homeostasis, bacterial translocation, and colitogenic Th17 responses in mice. J Clin Invest 121(12):4787-95. PubMed: 22045567 MGI: J:184030
Meisner JK; Song J; Price RJ. 2012. Arteriolar and venular remodeling are differentially regulated by bone marrow-derived cell-specific CX3CR1 and CCR2 expression. PLoS One 7(9):e46312. PubMed: 23029475 MGI: J:191962
Mesa KR; Rompolas P; Zito G; Myung P; Sun TY; Brown S; Gonzalez DG; Blagoev KB; Haberman AM; Greco V. 2015. Niche-induced cell death and epithelial phagocytosis regulate hair follicle stem cell pool. Nature 522(7554):94-7. PubMed: 25849774 MGI: J:226377
Meyer-Luehmann M; Spires-Jones TL; Prada C; Garcia-Alloza M; de Calignon A; Rozkalne A; Koenigsknecht-Talboo J; Holtzman DM; Bacskai BJ; Hyman BT. 2008. Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease. Nature 451(7179):720-4. PubMed: 18256671 MGI: J:132628
Michaud JP; Bellavance MA; Prefontaine P; Rivest S. 2013. Real-time in vivo imaging reveals the ability of monocytes to clear vascular amyloid beta. Cell Rep 5(3):646-53. PubMed: 24210819 MGI: J:205530
Milo I; Sapoznikov A; Kalchenko V; Tal O; Krauthgamer R; van Rooijen N; Dudziak D; Jung S; Shakhar G. 2013. Dynamic imaging reveals promiscuous crosspresentation of blood-borne antigens to naive CD8+ T cells in the bone marrow. Blood 122(2):193-208. PubMed: 23637125 MGI: J:200965
Mionnet C; Buatois V; Kanda A; Milcent V; Fleury S; Lair D; Langelot M; Lacoeuille Y; Hessel E; Coffman R; Magnan A; Dombrowicz D; Glaichenhaus N; Julia V. 2010. CX3CR1 is required for airway inflammation by promoting T helper cell survival and maintenance in inflamed lung. Nat Med 16(11):1305-12. PubMed: 21037587 MGI: J:166138
Misharin AV; Cuda CM; Saber R; Turner JD; Gierut AK; Haines GK 3rd; Berdnikovs S; Filer A; Clark AR; Buckley CD; Mutlu GM; Budinger GR; Perlman H. 2014. Nonclassical Ly6C(-) monocytes drive the development of inflammatory arthritis in mice. Cell Rep 9(2):591-604. PubMed: 25373902 MGI: J:218528
Mizutani M; Pino PA; Saederup N; Charo IF; Ransohoff RM; Cardona AE. 2012. The fractalkine receptor but not CCR2 is present on microglia from embryonic development throughout adulthood. J Immunol 188(1):29-36. PubMed: 22079990 MGI: J:180400
Mohammad MG; Tsai VW; Ruitenberg MJ; Hassanpour M; Li H; Hart PH; Breit SN; Sawchenko PE; Brown DA. 2014. Immune cell trafficking from the brain maintains CNS immune tolerance. J Clin Invest 124(3):1228-41. PubMed: 24569378 MGI: J:209720
Molawi K; Wolf Y; Kandalla PK; Favret J; Hagemeyer N; Frenzel K; Pinto AR; Klapproth K; Henri S; Malissen B; Rodewald HR; Rosenthal NA; Bajenoff M; Prinz M; Jung S; Sieweke MH. 2014. Progressive replacement of embryo-derived cardiac macrophages with age. J Exp Med 211(11):2151-8. PubMed: 25245760 MGI: J:218679
Mollah SA; Dobrin JS; Feder RE; Tse SW; Matos IG; Cheong C; Steinman RM; Anandasabapathy N. 2014. Flt3L Dependence Helps Define an Uncharacterized Subset of Murine Cutaneous Dendritic Cells. (Correction: J Invest Dermatol 2014;134:2850) J Invest Dermatol 134(5):1265-75. PubMed: 24288007 MGI: J:208074
Morganti JM; Jopson TD; Liu S; Gupta N; Rosi S. 2014. Cranial irradiation alters the brain's microenvironment and permits CCR2+ macrophage infiltration. PLoS One 9(4):e93650. PubMed: 24695541 MGI: J:215032
Morimura S; Sugaya M; Sato S. 2013. Interaction between CX3CL1 and CX3CR1 Regulates Vasculitis Induced by Immune Complex Deposition. Am J Pathol 182(5):1640-7. PubMed: 23470165 MGI: J:195540
Moriwaki K; Balaji S; Bertin J; Gough PJ; Chan FK. 2017. Distinct Kinase-Independent Role of RIPK3 in CD11c+ Mononuclear Phagocytes in Cytokine-Induced Tissue Repair. Cell Rep 18(10):2441-2451. PubMed: 28273458 MGI: J:239293
Morris DL; Cho KW; Delproposto JL; Oatmen KE; Geletka LM; Martinez-Santibanez G; Singer K; Lumeng CN. 2013. Adipose tissue macrophages function as antigen-presenting cells and regulate adipose tissue CD4+ T cells in mice. Diabetes 62(8):2762-72. PubMed: 23493569 MGI: J:208974
Morrison HW; Filosa JA. 2016. Sex differences in astrocyte and microglia responses immediately following middle cerebral artery occlusion in adult mice. Neuroscience 339:85-99. PubMed: 27717807 MGI: J:238200
Morselli E; Fuente-Martin E; Finan B; Kim M; Frank A; Garcia-Caceres C; Navas CR; Gordillo R; Neinast M; Kalainayakan SP; Li DL; Gao Y; Yi CX; Hahner L; Palmer BF; Tschop MH; Clegg DJ. 2014. Hypothalamic PGC-1alpha protects against high-fat diet exposure by regulating ERalpha. Cell Rep 9(2):633-45. PubMed: 25373903 MGI: J:218527
Motley MP; Madsen DH; Jurgensen HJ; Spencer DE; Szabo R; Holmbeck K; Flick MJ; Lawrence DA; Castellino FJ; Weigert R; Bugge TH. 2016. A CCR2 macrophage endocytic pathway mediates extravascular fibrin clearance in vivo. Blood 127(9):1085-96. PubMed: 26647393 MGI: J:232502
Mounier R; Theret M; Arnold L; Cuvellier S; Bultot L; Goransson O; Sanz N; Ferry A; Sakamoto K; Foretz M; Viollet B; Chazaud B. 2013. AMPKalpha1 regulates macrophage skewing at the time of resolution of inflammation during skeletal muscle regeneration. Cell Metab 18(2):251-64. PubMed: 23931756 MGI: J:200988
Mueller-Steiner S; Zhou Y; Arai H; Roberson ED; Sun B; Chen J; Wang X; Yu G; Esposito L; Mucke L; Gan L. 2006. Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease. Neuron 51(6):703-14. PubMed: 16982417 MGI: J:113649
Muller PA; Koscso B; Rajani GM; Stevanovic K; Berres ML; Hashimoto D; Mortha A; Leboeuf M; Li XM; Mucida D; Stanley ER; Dahan S; Margolis KG; Gershon MD; Merad M; Bogunovic M. 2014. Crosstalk between muscularis macrophages and enteric neurons regulates gastrointestinal motility. Cell 158(2):300-13. PubMed: 25036630 MGI: J:214621
Nahrendorf M; Swirski FK; Aikawa E; Stangenberg L; Wurdinger T; Figueiredo JL; Libby P; Weissleder R; Pittet MJ. 2007. The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions. J Exp Med 204(12):3037-47. PubMed: 18025128 MGI: J:128499
Narni-Mancinelli E; Soudja SM; Crozat K; Dalod M; Gounon P; Geissmann F; Lauvau G. 2011. Inflammatory monocytes and neutrophils are licensed to kill during memory responses in vivo. PLoS Pathog 7(12):e1002457. PubMed: 22241983 MGI: J:237966
Nayak D; Johnson KR; Heydari S; Roth TL; Zinselmeyer BH; McGavern DB. 2013. Type I interferon programs innate myeloid dynamics and gene expression in the virally infected nervous system. PLoS Pathog 9(5):e1003395. PubMed: 23737750 MGI: J:213399
Niess JH; Adler G. 2010. Enteric flora expands gut lamina propria CX3CR1+ dendritic cells supporting inflammatory immune responses under normal and inflammatory conditions. J Immunol 184(4):2026-37. PubMed: 20089703 MGI: J:159471
Niess JH; Brand S; Gu X; Landsman L; Jung S; McCormick BA; Vyas JM; Boes M; Ploegh HL; Fox JG; Littman DR; Reinecker HC. 2005. CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science 307(5707):254-8. PubMed: 15653504 MGI: J:95694
O'Koren EG; Hogan BL; Gunn MD. 2013. Loss of basal cells precedes bronchiolitis obliterans-like pathological changes in a murine model of chlorine gas inhalation. Am J Respir Cell Mol Biol 49(5):788-97. PubMed: 23742075 MGI: J:231570
Oberbarnscheidt MH; Zeng Q; Li Q; Dai H; Williams AL; Shlomchik WD; Rothstein DM; Lakkis FG. 2014. Non-self recognition by monocytes initiates allograft rejection. J Clin Invest 124(8):3579-89. PubMed: 24983319 MGI: J:213858
Old EA; Nadkarni S; Grist J; Gentry C; Bevan S; Kim KW; Mogg AJ; Perretti M; Malcangio M. 2014. Monocytes expressing CX3CR1 orchestrate the development of vincristine-induced pain. J Clin Invest 124(5):2023-36. PubMed: 24743146 MGI: J:212753
Orr AG; Orr AL; Li XJ; Gross RE; Traynelis SF. 2009. Adenosine A(2A) receptor mediates microglial process retraction. Nat Neurosci 12(7):872-8. PubMed: 19525944 MGI: J:163956
Paolicelli RC; Bolasco G; Pagani F; Maggi L; Scianni M; Panzanelli P; Giustetto M; Ferreira TA; Guiducci E; Dumas L; Ragozzino D; Gross CT. 2011. Synaptic pruning by microglia is necessary for normal brain development. Science 333(6048):1456-8. PubMed: 21778362 MGI: J:175794
Pasquevich KA; Bieber K; Gunter M; Grauer M; Potz O; Schleicher U; Biedermann T; Beer-Hammer S; Buhring HJ; Rammensee HG; Zender L; Autenrieth IB; Lengerke C; Autenrieth SE. 2015. Innate immune system favors emergency monopoiesis at the expense of DC-differentiation to control systemic bacterial infection in mice. Eur J Immunol 45(10):2821-33. PubMed: 26138432 MGI: J:233063
Peng B; Xiao J; Wang K; So KF; Tipoe GL; Lin B. 2014. Suppression of microglial activation is neuroprotective in a mouse model of human retinitis pigmentosa. J Neurosci 34(24):8139-50. PubMed: 24920619 MGI: J:211708
Peng J; Gu N; Zhou L; B Eyo U; Murugan M; Gan WB; Wu LJ. 2016. Microglia and monocytes synergistically promote the transition from acute to chronic pain after nerve injury. Nat Commun 7:12029. PubMed: 27349690 MGI: J:240065
Persson EK; Uronen-Hansson H; Semmrich M; Rivollier A; Hagerbrand K; Marsal J; Gudjonsson S; Hakansson U; Reizis B; Kotarsky K; Agace WW. 2013. IRF4 transcription-factor-dependent CD103(+)CD11b(+) dendritic cells drive mucosal T helper 17 cell differentiation. Immunity 38(5):958-69. PubMed: 23664832 MGI: J:203154
Pinto AR; Paolicelli R; Salimova E; Gospocic J; Slonimsky E; Bilbao-Cortes D; Godwin JW; Rosenthal NA. 2012. An abundant tissue macrophage population in the adult murine heart with a distinct alternatively-activated macrophage profile. PLoS One 7(5):e36814. PubMed: 22590615 MGI: J:187247
Plaks V; Boldajipour B; Linnemann JR; Nguyen NH; Kersten K; Wolf Y; Casbon AJ; Kong N; van den Bijgaart RJ; Sheppard D; Melton AC; Krummel MF; Werb Z. 2015. Adaptive Immune Regulation of Mammary Postnatal Organogenesis. Dev Cell 34(5):493-504. PubMed: 26321127 MGI: J:239781
Platt AM; Bain CC; Bordon Y; Sester DP; Mowat AM. 2010. An independent subset of TLR expressing CCR2-dependent macrophages promotes colonic inflammation. J Immunol 184(12):6843-54. PubMed: 20483766 MGI: J:161138
Ponzetta A; Sciume G; Benigni G; Antonangeli F; Morrone S; Santoni A; Bernardini G. 2013. CX3CR1 regulates the maintenance of KLRG1+ NK cells into the bone marrow by promoting their entry into circulation. J Immunol 191(11):5684-94. PubMed: 24184559 MGI: J:207151
Postea O; Vasina EM; Cauwenberghs S; Projahn D; Liehn EA; Lievens D; Theelen W; Kramp BK; Butoi ED; Soehnlein O; Heemskerk JW; Ludwig A; Weber C; Koenen RR. 2012. Contribution of platelet CX(3)CR1 to platelet-monocyte complex formation and vascular recruitment during hyperlipidemia. Arterioscler Thromb Vasc Biol 32(5):1186-93. PubMed: 22383701 MGI: J:196930
Poupel L; Boissonnas A; Hermand P; Dorgham K; Guyon E; Auvynet C; Charles FS; Lesnik P; Deterre P; Combadiere C. 2013. Pharmacological inhibition of the chemokine receptor, CX3CR1, reduces atherosclerosis in mice. Arterioscler Thromb Vasc Biol 33(10):2297-305. PubMed: 23887641 MGI: J:222227
Preissler J; Grosche A; Lede V; Le Duc D; Krugel K; Matyash V; Szulzewsky F; Kallendrusch S; Immig K; Kettenmann H; Bechmann I; Schoneberg T; Schulz A. 2015. Altered microglial phagocytosis in GPR34-deficient mice. Glia 63(2):206-15. PubMed: 25142016 MGI: J:217768
Qu C; Edwards EW; Tacke F; Angeli V; Llodra J; Sanchez-Schmitz G; Garin A; Haque NS; Peters W; van Rooijen N; Sanchez-Torres C; Bromberg J; Charo IF; Jung S; Lira SA; Randolph GJ. 2004. Role of CCR8 and other chemokine pathways in the migration of monocyte-derived dendritic cells to lymph nodes. J Exp Med 200(10):1231-41. PubMed: 15534368 MGI: J:94536
Ran L; Yu Q; Zhang S; Xiong F; Cheng J; Yang P; Xu JF; Nie H; Zhong Q; Yang X; Yang F; Gong Q; Kuczma M; Kraj P; Gu W; Ren BX; Wang CY. 2015. Cx3cr1 deficiency in mice attenuates hepatic granuloma formation during acute schistosomiasis by enhancing the M2-type polarization of macrophages. Dis Model Mech 8(7):691-700. PubMed: 26035381 MGI: J:223919
Rangasamy S; McGuire PG; Franco Nitta C; Monickaraj F; Oruganti SR; Das A. 2014. Chemokine mediated monocyte trafficking into the retina: role of inflammation in alteration of the blood-retinal barrier in diabetic retinopathy. PLoS One 9(10):e108508. PubMed: 25329075 MGI: J:223555
Raposo C; Graubardt N; Cohen M; Eitan C; London A; Berkutzki T; Schwartz M. 2014. CNS repair requires both effector and regulatory T cells with distinct temporal and spatial profiles. J Neurosci 34(31):10141-55. PubMed: 25080578 MGI: J:215779
Rasmussen TP; Wu Y; Joiner ML; Koval OM; Wilson NR; Luczak ED; Wang Q; Chen B; Gao Z; Zhu Z; Wagner BA; Soto J; McCormick ML; Kutschke W; Weiss RM; Yu L; Boudreau RL; Abel ED; Zhan F; Spitz DR; Buettner GR; Song LS; Zingman LV; Anderson ME. 2015. Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart. Proc Natl Acad Sci U S A 112(29):9129-34. PubMed: 26153425 MGI: J:223794
Ribeiro Xavier AL; Kress BT; Goldman SA; Lacerda de Menezes JR; Nedergaard M. 2015. A Distinct Population of Microglia Supports Adult Neurogenesis in the Subventricular Zone. J Neurosci 35(34):11848-11861. PubMed: 26311768 MGI: J:223788
Richter N; Wendt S; Georgieva PB; Hambardzumyan D; Nolte C; Kettenmann H. 2014. Glioma-associated microglia and macrophages/monocytes display distinct electrophysiological properties and do not communicate via gap junctions. Neurosci Lett 583:130-5. PubMed: 25261595 MGI: J:215530
Rigato C; Swinnen N; Buckinx R; Couillin I; Mangin JM; Rigo JM; Legendre P; Le Corronc H. 2012. Microglia Proliferation Is Controlled by P2X7 Receptors in a Pannexin-1-Independent Manner during Early Embryonic Spinal Cord Invasion. J Neurosci 32(34):11559-11573. PubMed: 22915101 MGI: J:187706
Rius C; Piqueras L; Gonzalez-Navarro H; Albertos F; Company C; Lopez-Gines C; Ludwig A; Blanes JI; Morcillo EJ; Sanz MJ. 2013. Arterial and venous endothelia display differential functional fractalkine (CX3CL1) expression by angiotensin-II. Arterioscler Thromb Vasc Biol 33(1):96-104. PubMed: 23117657 MGI: J:216918
Rivollier A; He J; Kole A; Valatas V; Kelsall BL. 2012. Inflammation switches the differentiation program of Ly6Chi monocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon. J Exp Med 209(1):139-55. PubMed: 22231304 MGI: J:181701
Rodero MP; Licata F; Poupel L; Hamon P; Khosrotehrani K; Combadiere C; Boissonnas A. 2014. In vivo imaging reveals a pioneer wave of monocyte recruitment into mouse skin wounds. PLoS One 9(10):e108212. PubMed: 25272047 MGI: J:223477
Rodero MP; Poupel L; Loyher PL; Hamon P; Licata F; Pessel C; Hume DA; Combadiere C; Boissonnas A. 2015. Immune surveillance of the lung by migrating tissue monocytes. Elife 4:e07847. PubMed: 26167653 MGI: J:225982
Rogers JT; Morganti JM; Bachstetter AD; Hudson CE; Peters MM; Grimmig BA; Weeber EJ; Bickford PC; Gemma C. 2011. CX3CR1 Deficiency Leads to Impairment of Hippocampal Cognitive Function and Synaptic Plasticity. J Neurosci 31(45):16241-50. PubMed: 22072675 MGI: J:177835
Rotzius P; Thams S; Soehnlein O; Kenne E; Tseng CN; Bjorkstrom NK; Malmberg KJ; Lindbom L; Eriksson EE. 2010. Distinct infiltration of neutrophils in lesion shoulders in ApoE-/- mice. Am J Pathol 177(1):493-500. PubMed: 20472897 MGI: J:162128
Ryu JK; Petersen MA; Murray SG; Baeten KM; Meyer-Franke A; Chan JP; Vagena E; Bedard C; Machado MR; Rios Coronado PE; Prod'homme T; Charo IF; Lassmann H; Degen JL; Zamvil SS; Akassoglou K. 2015. Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation. Nat Commun 6:8164. PubMed: 26353940 MGI: J:227017
Saederup N; Cardona AE; Croft K; Mizutani M; Cotleur AC; Tsou CL; Ransohoff RM; Charo IF. 2010. Selective chemokine receptor usage by central nervous system myeloid cells in CCR2-red fluorescent protein knock-in mice. PLoS One 5(10):e13693. PubMed: 21060874 MGI: J:166664
Salazar-Gonzalez RM; Niess JH; Zammit DJ; Ravindran R; Srinivasan A; Maxwell JR; Stoklasek T; Yadav R; Williams IR; Gu X; McCormick BA; Pazos MA; Vella AT; Lefrancois L; Reinecker HC; McSorley SJ. 2006. CCR6-mediated dendritic cell activation of pathogen-specific T cells in Peyer's patches. Immunity 24(5):623-32. PubMed: 16713979 MGI: J:113363
Sapoznikov A; Pewzner-Jung Y; Kalchenko V; Krauthgamer R; Shachar I; Jung S. 2008. Perivascular clusters of dendritic cells provide critical survival signals to B cells in bone marrow niches. Nat Immunol 9(4):388-95. PubMed: 18311142 MGI: J:133263
Sathaliyawala T; O'Gorman WE; Greter M; Bogunovic M; Konjufca V; Hou ZE; Nolan GP; Miller MJ; Merad M; Reizis B. 2010. Mammalian target of rapamycin controls dendritic cell development downstream of flt3 ligand signaling. Immunity 33(4):597-606. PubMed: 20933441 MGI: J:165522
Satpathy AT; Briseno CG; Lee JS; Ng D; Manieri NA; Kc W; Wu X; Thomas SR; Lee WL; Turkoz M; McDonald KG; Meredith MM; Song C; Guidos CJ; Newberry RD; Ouyang W; Murphy TL; Stappenbeck TS; Gommerman JL; Nussenzweig MC; Colonna M; Kopan R; Murphy KM. 2013. Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens. Nat Immunol 14(9):937-48. PubMed: 23913046 MGI: J:208234
Sawanobori Y; Ueha S; Kurachi M; Shimaoka T; Talmadge JE; Abe J; Shono Y; Kitabatake M; Kakimi K; Mukaida N; Matsushima K. 2008. Chemokine-mediated rapid turnover of myeloid-derived suppressor cells in tumor-bearing mice. Blood 111(12):5457-66. PubMed: 18375791 MGI: J:136844
Schafer DP; Heller CT; Gunner G; Heller M; Gordon C; Hammond T; Wolf Y; Jung S; Stevens B. 2016. Microglia contribute to circuit defects in Mecp2 null mice independent of microglia-specific loss of Mecp2 expression. Elife 5:. PubMed: 27458802 MGI: J:235289
Schallner N; Pandit R; LeBlanc R 3rd; Thomas AJ; Ogilvy CS; Zuckerbraun BS; Gallo D; Otterbein LE; Hanafy KA. 2015. Microglia regulate blood clearance in subarachnoid hemorrhage by heme oxygenase-1. J Clin Invest 125(7):2609-25. PubMed: 26011640 MGI: J:224477
Schlitzer A; Heiseke AF; Einwachter H; Reindl W; Schiemann M; Manta CP; See P; Niess JH; Suter T; Ginhoux F; Krug AB. 2012. Tissue-specific differentiation of a circulating CCR9- pDC-like common dendritic cell precursor. Blood 119(25):6063-71. PubMed: 22547585 MGI: J:188636
Schlitzer A; McGovern N; Teo P; Zelante T; Atarashi K; Low D; Ho AW; See P; Shin A; Wasan PS; Hoeffel G; Malleret B; Heiseke A; Chew S; Jardine L; Purvis HA; Hilkens CM; Tam J; Poidinger M; Stanley ER; Krug AB; Renia L; Sivasankar B; Ng LG; Collin M; Ricciardi-Castagnoli P; Honda K; Haniffa M; Ginhoux F. 2013. IRF4 transcription factor-dependent CD11b+ dendritic cells in human and mouse control mucosal IL-17 cytokine responses. Immunity 38(5):970-83. PubMed: 23706669 MGI: J:203145
Schlitzer A; Sivakamasundari V; Chen J; Sumatoh HR; Schreuder J; Lum J; Malleret B; Zhang S; Larbi A; Zolezzi F; Renia L; Poidinger M; Naik S; Newell EW; Robson P; Ginhoux F. 2015. Identification of cDC1- and cDC2-committed DC progenitors reveals early lineage priming at the common DC progenitor stage in the bone marrow. Nat Immunol 16(7):718-28. PubMed: 26054720 MGI: J:232962
Schulz C; Gomez Perdiguero E; Chorro L; Szabo-Rogers H; Cagnard N; Kierdorf K; Prinz M; Wu B; Jacobsen SE; Pollard JW; Frampton J; Liu KJ; Geissmann F. 2012. A lineage of myeloid cells independent of Myb and hematopoietic stem cells. Science 336(6077):86-90. PubMed: 22442384 MGI: J:182209
Schulz O; Jaensson E; Persson EK; Liu X; Worbs T; Agace WW; Pabst O. 2009. Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions. J Exp Med 206(13):3101-14. PubMed: 20008524 MGI: J:155671
Sciume G; De Angelis G; Benigni G; Ponzetta A; Morrone S; Santoni A; Bernardini G. 2011. CX3CR1 expression defines 2 KLRG1+ mouse NK-cell subsets with distinct functional properties and positioning in the bone marrow. Blood 117(17):4467-75. PubMed: 21364193 MGI: J:177799
Seeley EJ; Barry SS; Narala S; Matthay MA; Wolters PJ. 2013. Noradrenergic Neurons Regulate Monocyte Trafficking and Mortality during Gram-Negative Peritonitis in Mice. J Immunol 190(9):4717-24. PubMed: 23543756 MGI: J:195507
Seillet C; Jackson JT; Markey KA; Brady HJ; Hill GR; Macdonald KP; Nutt SL; Belz GT. 2013. CD8alpha+ DCs can be induced in the absence of transcription factors Id2, Nfil3, and Batf3. Blood 121(9):1574-83. PubMed: 23297132 MGI: J:194760
Seyed-Razavi Y; Chinnery HR; McMenamin PG. 2014. A novel association between resident tissue macrophages and nerves in the peripheral stroma of the murine cornea. Invest Ophthalmol Vis Sci 55(3):1313-20. PubMed: 24458151 MGI: J:229287
Shechter R; London A; Kuperman Y; Ronen A; Rolls A; Chen A; Schwartz M. 2013. Hypothalamic neuronal toll-like receptor 2 protects against age-induced obesity. Sci Rep 3:1254. PubMed: 23409245 MGI: J:207263
Shechter R; Miller O; Yovel G; Rosenzweig N; London A; Ruckh J; Kim KW; Klein E; Kalchenko V; Bendel P; Lira SA; Jung S; Schwartz M. 2013. Recruitment of beneficial m2 macrophages to injured spinal cord is orchestrated by remote brain choroid plexus. Immunity 38(3):555-69. PubMed: 23477737 MGI: J:194904
Shibuya Y; Chang CC; Huang LH; Bryleva EY; Chang TY. 2014. Inhibiting ACAT1/SOAT1 in microglia stimulates autophagy-mediated lysosomal proteolysis and increases Abeta1-42 clearance. J Neurosci 34(43):14484-501. PubMed: 25339759 MGI: J:217151
Shum WW; Smith TB; Cortez-Retamozo V; Grigoryeva LS; Roy JW; Hill E; Pittet MJ; Breton S; Da Silva N. 2014. Epithelial basal cells are distinct from dendritic cells and macrophages in the mouse epididymis. Biol Reprod 90(5):90. PubMed: 24648397 MGI: J:210305
Soehnlein O; Zernecke A; Eriksson EE; Rothfuchs AG; Pham CT; Herwald H; Bidzhekov K; Rottenberg ME; Weber C; Lindbom L. 2008. Neutrophil secretion products pave the way for inflammatory monocytes. Blood 112(4):1461-71. PubMed: 18490516 MGI: J:138439
Song JW; Misgeld T; Kang H; Knecht S; Lu J; Cao Y; Cotman SL; Bishop DL; Lichtman JW. 2008. Lysosomal activity associated with developmental axon pruning. J Neurosci 28(36):8993-9001. PubMed: 18768693 MGI: J:141170
Song KH; Park J; Park JH; Natarajan R; Ha H. 2013. Fractalkine and its receptor mediate extracellular matrix accumulation in diabetic nephropathy in mice. Diabetologia 56(7):1661-9. PubMed: 23604552 MGI: J:198960
Stark K; Philippi V; Stockhausen S; Busse J; Antonelli A; Miller M; Schubert I; Hoseinpour P; Chandraratne S; von Bruhl ML; Gaertner F; Lorenz M; Agresti A; Coletti R; Antoine DJ; Heermann R; Jung K; Reese S; Laitinen I; Schwaiger M; Walch A; Sperandio M; Nawroth PP; Reinhardt C; Jackel S; Bianchi ME; Massberg S. 2016. Disulfide HMGB1 derived from platelets coordinates venous thrombosis in mice. Blood 128(20):2435-2449. PubMed: 27574188 MGI: J:237387
Staumont-Salle D; Fleury S; Lazzari A; Molendi-Coste O; Hornez N; Lavogiez C; Kanda A; Wartelle J; Fries A; Pennino D; Mionnet C; Prawitt J; Bouchaert E; Delaporte E; Glaichenhaus N; Staels B; Julia V; Dombrowicz D. 2014. CX(3)CL1 (fractalkine) and its receptor CX(3)CR1 regulate atopic dermatitis by controlling effector T cell retention in inflamed skin. J Exp Med 211(6):1185-96. PubMed: 24821910 MGI: J:213740
Stephan AH; Madison DV; Mateos JM; Fraser DA; Lovelett EA; Coutellier L; Kim L; Tsai HH; Huang EJ; Rowitch DH; Berns DS; Tenner AJ; Shamloo M; Barres BA. 2013. A Dramatic Increase of C1q Protein in the CNS during Normal Aging. J Neurosci 33(33):13460-13474. PubMed: 23946404 MGI: J:200899
Sun K; Yajjala VK; Bauer C; Talmon GA; Fischer KJ; Kielian T; Metzger DW. 2016. Nox2-derived oxidative stress results in inefficacy of antibiotics against post-influenza S. aureus pneumonia. J Exp Med 213(9):1851-64. PubMed: 27526712 MGI: J:236726
Sundberg TB; Choi HG; Song JH; Russell CN; Hussain MM; Graham DB; Khor B; Gagnon J; O'Connell DJ; Narayan K; Dancik V; Perez JR; Reinecker HC; Gray NS; Schreiber SL; Xavier RJ; Shamji AF. 2014. Small-molecule screening identifies inhibition of salt-inducible kinases as a therapeutic strategy to enhance immunoregulatory functions of dendritic cells. Proc Natl Acad Sci U S A 111(34):12468-73. PubMed: 25114223 MGI: J:213913
Swiatkowski P; Murugan M; Eyo UB; Wang Y; Rangaraju S; Oh SB; Wu LJ. 2016. Activation of microglial P2Y12 receptor is required for outward potassium currents in response to neuronal injury. Neuroscience 318:22-33. PubMed: 26791526 MGI: J:231373
Swinnen N; Smolders S; Avila A; Notelaers K; Paesen R; Ameloot M; Brone B; Legendre P; Rigo JM. 2013. Complex invasion pattern of the cerebral cortex bymicroglial cells during development of the mouse embryo. Glia 61(2):150-63. PubMed: 23001583 MGI: J:191146
Synowitz M; Glass R; Farber K; Markovic D; Kronenberg G; Herrmann K; Schnermann J; Nolte C; van Rooijen N; Kiwit J; Kettenmann H. 2006. A1 adenosine receptors in microglia control glioblastoma-host interaction. Cancer Res 66(17):8550-7. PubMed: 16951167 MGI: J:112410
Szalay G; Martinecz B; Lenart N; Kornyei Z; Orsolits B; Judak L; Csaszar E; Fekete R; West BL; Katona G; Rozsa B; Denes A. 2016. Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke. Nat Commun 7:11499. PubMed: 27139776 MGI: J:239941
Tacke F; Alvarez D; Kaplan TJ; Jakubzick C; Spanbroek R; Llodra J; Garin A; Liu J; Mack M; van Rooijen N; Lira SA; Habenicht AJ; Randolph GJ. 2007. Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques. J Clin Invest 117(1):185-94. PubMed: 17200718 MGI: J:117437
Tagliani E; Shi C; Nancy P; Tay CS; Pamer EG; Erlebacher A. 2011. Coordinate regulation of tissue macrophage and dendritic cell population dynamics by CSF-1. J Exp Med 208(9):1901-16. PubMed: 21825019 MGI: J:177594
Tamoutounour S; Henri S; Lelouard H; de Bovis B; de Haar C; van der Woude CJ; Woltman AM; Reyal Y; Bonnet D; Sichien D; Bain CC; Mowat AM; Reis E Sousa C; Poulin LF; Malissen B; Guilliams M. 2012. CD64 distinguishes macrophages from dendritic cells in the gut and reveals the Th1-inducing role of mesenteric lymph node macrophages during colitis. Eur J Immunol 42(12):3150-66. PubMed: 22936024 MGI: J:190343
Taylor RA; Chang CF; Goods BA; Hammond MD; Mac Grory B; Ai Y; Steinschneider AF; Renfroe SC; Askenase MH; McCullough LD; Kasner SE; Mullen MT; Hafler DA; Love JC; Sansing LH. 2017. TGF-beta1 modulates microglial phenotype and promotes recovery after intracerebral hemorrhage. J Clin Invest 127(1):280-292. PubMed: 27893460 MGI: J:239742
Taylor RA; Hammond MD; Ai Y; Sansing LH. 2014. CX3CR1 signaling on monocytes is dispensable after intracerebral hemorrhage. PLoS One 9(12):e114472. PubMed: 25469644 MGI: J:225693
Thomas DM; Francescutti-Verbeem DM; Kuhn DM. 2008. Methamphetamine-induced neurotoxicity and microglial activation are not mediated by fractalkine receptor signaling. J Neurochem 106(2):696-705. PubMed: 18410508 MGI: J:139390
Tighe RM; Li Z; Potts EN; Frush S; Liu N; Gunn MD; Foster WM; Noble PW; Hollingsworth JW. 2011. Ozone inhalation promotes CX3CR1-dependent maturation of resident lung macrophages that limit oxidative stress and inflammation. J Immunol 187(9):4800-8. PubMed: 21930959 MGI: J:179462
Tussiwand R; Everts B; Grajales-Reyes GE; Kretzer NM; Iwata A; Bagaitkar J; Wu X; Wong R; Anderson DA; Murphy TL; Pearce EJ; Murphy KM. 2015. Klf4 expression in conventional dendritic cells is required for T helper 2 cell responses. Immunity 42(5):916-28. PubMed: 25992862 MGI: J:229740
Ueno M; Fujita Y; Tanaka T; Nakamura Y; Kikuta J; Ishii M; Yamashita T. 2013. Layer V cortical neurons require microglial support for survival during postnatal development. Nat Neurosci 16(5):543-51. PubMed: 23525041 MGI: J:197621
Ulmann L; Hirbec H; Rassendren F. 2010. P2X4 receptors mediate PGE2 release by tissue-resident macrophages and initiate inflammatory pain. EMBO J 29(14):2290-300. PubMed: 20562826 MGI: J:162082
Ulmann L; Levavasseur F; Avignone E; Peyroutou R; Hirbec H; Audinat E; Rassendren F. 2013. Involvement of P2X4 receptors in hippocampal microglial activation after status epilepticus. Glia 61(8):1306-19. PubMed: 23828736 MGI: J:199452
Vagaja NN; Chinnery HR; Binz N; Kezic JM; Rakoczy EP; McMenamin PG. 2012. Changes in murine hyalocytes are valuable early indicators of ocular disease. Invest Ophthalmol Vis Sci 53(3):1445-51. PubMed: 22297487 MGI: J:196754
Vaknin I; Kunis G; Miller O; Butovsky O; Bukshpan S; Beers DR; Henkel JS; Yoles E; Appel SH; Schwartz M. 2011. Excess circulating alternatively activated myeloid (M2) cells accelerate ALS progression while inhibiting experimental autoimmune encephalomyelitis. PLoS One 6(11):e26921. PubMed: 22073221 MGI: J:180998
Vallon-Eberhard A; Landsman L; Yogev N; Verrier B; Jung S. 2006. Transepithelial pathogen uptake into the small intestinal lamina propria. J Immunol 176(4):2465-9. PubMed: 16456006 MGI: J:106225
Van Overmeire E; Stijlemans B; Heymann F; Keirsse J; Morias Y; Elkrim Y; Brys L; Abels C; Lahmar Q; Ergen C; Vereecke L; Tacke F; De Baetselier P; Van Ginderachter JA; Laoui D. 2016. M-CSF and GM-CSF Receptor Signaling Differentially Regulate Monocyte Maturation and Macrophage Polarization in the Tumor Microenvironment. Cancer Res 76(1):35-42. PubMed: 26573801 MGI: J:230585
Varol C; Landsman L; Fogg DK; Greenshtein L; Gildor B; Margalit R; Kalchenko V; Geissmann F; Jung S. 2007. Monocytes give rise to mucosal, but not splenic, conventional dendritic cells. J Exp Med 204(1):171-80. PubMed: 17190836 MGI: J:125312
Varol C; Vallon-Eberhard A; Elinav E; Aychek T; Shapira Y; Luche H; Fehling HJ; Hardt WD; Shakhar G; Jung S. 2009. Intestinal lamina propria dendritic cell subsets have different origin and functions. Immunity 31(3):502-12. PubMed: 19733097 MGI: J:152689
Varvel NH; Bhaskar K; Kounnas MZ; Wagner SL; Yang Y; Lamb BT; Herrup K. 2009. NSAIDs prevent, but do not reverse, neuronal cell cycle reentry in a mouse model of Alzheimer disease. J Clin Invest 119(12):3692-702. PubMed: 19907078 MGI: J:155100
Vessey KA; Greferath U; Jobling AI; Phipps JA; Ho T; Waugh M; Fletcher EL. 2012. Ccl2/Cx3cr1 knockout mice have inner retinal dysfunction but are not an accelerated model of AMD. Invest Ophthalmol Vis Sci 53(12):7833-46. PubMed: 23074204 MGI: J:214216
Vukovic J; Blomster LV; Chinnery HR; Weninger W; Jung S; McMenamin PG; Ruitenberg MJ. 2010. Bone marrow chimeric mice reveal a role for CXCR1 in maintenance of the monocyte-derived cell population in the olfactory neuroepithelium. J Leukoc Biol 88(4):645-54. PubMed: 20610801 MGI: J:165615
Vukovic J; Colditz MJ; Blackmore DG; Ruitenberg MJ; Bartlett PF. 2012. Microglia modulate hippocampal neural precursor activity in response to exercise and aging. J Neurosci 32(19):6435-43. PubMed: 22573666 MGI: J:184859
Waddell A; Ahrens R; Steinbrecher K; Donovan B; Rothenberg ME; Munitz A; Hogan SP. 2011. Colonic eosinophilic inflammation in experimental colitis is mediated by Ly6C(high) CCR2(+) inflammatory monocyte/macrophage-derived CCL11. J Immunol 186(10):5993-6003. PubMed: 21498668 MGI: J:173219
Wang J; Gusti V; Saraswati A; Lo DD. 2011. Convergent and divergent development among M cell lineages in mouse mucosal epithelium. J Immunol 187(10):5277-85. PubMed: 21984701 MGI: J:179643
Wang J; Kubes P. 2016. A Reservoir of Mature Cavity Macrophages that Can Rapidly Invade Visceral Organs to Affect Tissue Repair. Cell 165(3):668-78. PubMed: 27062926 MGI: J:234500
Wang K; Peng B; Lin B. 2014. Fractalkine receptor regulates microglial neurotoxicity in an experimental mouse glaucoma model. Glia 62(12):1943-54. PubMed: 24989686 MGI: J:214962
Wang Y; Cella M; Mallinson K; Ulrich JD; Young KL; Robinette ML; Gilfillan S; Krishnan GM; Sudhakar S; Zinselmeyer BH; Holtzman DM; Cirrito JR; Colonna M. 2015. TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model. Cell 160(6):1061-71. PubMed: 25728668 MGI: J:222876
Wantha S; Alard JE; Megens RT; van der Does AM; Doring Y; Drechsler M; Pham CT; Wang MW; Wang JM; Gallo RL; von Hundelshausen P; Lindbom L; Hackeng T; Weber C; Soehnlein O. 2013. Neutrophil-derived cathelicidin promotes adhesion of classical monocytes. Circ Res 112(5):792-801. PubMed: 23283724 MGI: J:212860
Weber B; Saurer L; Schenk M; Dickgreber N; Mueller C. 2011. CX3CR1 defines functionally distinct intestinal mononuclear phagocyte subsets which maintain their respective functions during homeostatic and inflammatory conditions. Eur J Immunol 41(3):773-9. PubMed: 21341263 MGI: J:175420
Willart MA; Jan de Heer H; Hammad H; Soullie T; Deswarte K; Clausen BE; Boon L; Hoogsteden HC; Lambrecht BN. 2009. The lung vascular filter as a site of immune induction for T cell responses to large embolic antigen. J Exp Med 206(12):2823-35. PubMed: 19858325 MGI: J:154860
Wojcik AJ; Skaflen MD; Srinivasan S; Hedrick CC. 2008. A Critical Role for ABCG1 in Macrophage Inflammation and Lung Homeostasis. J Immunol 180(6):4273-82. PubMed: 18322240 MGI: J:132952
Wong HS; Jaumouille V; Freeman SA; Doodnauth SA; Schlam D; Canton J; Mukovozov IM; Saric A; Grinstein S; Robinson LA. 2016. Chemokine Signaling Enhances CD36 Responsiveness toward Oxidized Low-Density Lipoproteins and Accelerates Foam Cell Formation. Cell Rep 14(12):2859-71. PubMed: 26997267 MGI: J:234880
Woodfin A; Voisin MB; Beyrau M; Colom B; Caille D; Diapouli FM; Nash GB; Chavakis T; Albelda SM; Rainger GE; Meda P; Imhof BA; Nourshargh S. 2011. The junctional adhesion molecule JAM-C regulates polarized transendothelial migration of neutrophils in vivo. Nat Immunol 12(8):761-9. PubMed: 21706006 MGI: J:174437
Wu LJ; Vadakkan KI; Zhuo M. 2007. ATP-induced chemotaxis of microglial processes requires P2Y receptor-activated initiation of outward potassium currents. Glia 55(8):810-21. PubMed: 17357150 MGI: J:156095
Wu LJ; Wu G; Akhavan Sharif MR; Baker A; Jia Y; Fahey FH; Luo HR; Feener EP; Clapham DE. 2012. The voltage-gated proton channel Hv1 enhances brain damage from ischemic stroke. Nat Neurosci 15(4):565-73. PubMed: 22388960 MGI: J:191259
Xi H; Katschke KJ Jr; Helmy KY; Wark PA; Kljavin N; Clark H; Eastham-Anderson J; Shek T; Roose-Girma M; Ghilardi N; van Lookeren Campagne M. 2010. Negative regulation of autoimmune demyelination by the inhibitory receptor CLM-1. J Exp Med 207(1):7-16, S1-5. PubMed: 20038601 MGI: J:156819
Xiong Z; Leme AS; Ray P; Shapiro SD; Lee JS. 2011. CX3CR1+ Lung Mononuclear Phagocytes Spatially Confined to the Interstitium Produce TNF-{alpha} and IL-6 and Promote Cigarette Smoke-Induced Emphysema. J Immunol 186(5):3206-14. PubMed: 21278339 MGI: J:169385
Yamasaki R; Fujii T; Wang B; Masaki K; Kido MA; Yoshida M; Matsushita T; Kira JI. 2016. Allergic Inflammation Leads to Neuropathic Pain via Glial Cell Activation. J Neurosci 36(47):11929-11945. PubMed: 27881779 MGI: J:237192
Yamasaki R; Lu H; Butovsky O; Ohno N; Rietsch AM; Cialic R; Wu PM; Doykan CE; Lin J; Cotleur AC; Kidd G; Zorlu MM; Sun N; Hu W; Liu L; Lee JC; Taylor SE; Uehlein L; Dixon D; Gu J; Floruta CM; Zhu M; Charo IF; Weiner HL; Ransohoff RM. 2014. Differential roles of microglia and monocytes in the inflamed central nervous system. J Exp Med 211(8):1533-49. PubMed: 25002752 MGI: J:214724
Yang J; Yang H; Liu Y; Li X; Qin L; Lou H; Duan S; Wang H. 2016. Astrocytes contribute to synapse elimination via type 2 inositol 1,4,5-trisphosphate receptor-dependent release of ATP. Elife 5:. PubMed: 27067238 MGI: J:232107
Yin N; Xu J; Ginhoux F; Randolph GJ; Merad M; Ding Y; Bromberg JS. 2012. Functional specialization of islet dendritic cell subsets. J Immunol 188(10):4921-30. PubMed: 22508930 MGI: J:188667
Yona S; Kim KW; Wolf Y; Mildner A; Varol D; Breker M; Strauss-Ayali D; Viukov S; Guilliams M; Misharin A; Hume DA; Perlman H; Malissen B; Zelzer E; Jung S. 2013. Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis. Immunity 38(1):79-91. PubMed: 23273845 MGI: J:193038
Yun TJ; Lee JS; Machmach K; Shim D; Choi J; Wi YJ; Jang HS; Jung IH; Kim K; Yoon WK; Miah MA; Li B; Chang J; Bego MG; Pham TN; Loschko J; Fritz JH; Krug AB; Lee SP; Keler T; Guimond JV; Haddad E; Cohen EA; Sirois MG; El-Hamamsy I; Colonna M; Oh GT; Choi JH; Cheong C. 2016. Indoleamine 2,3-Dioxygenase-Expressing Aortic Plasmacytoid Dendritic Cells Protect against Atherosclerosis by Induction of Regulatory T Cells. Cell Metab 23(5):852-66. PubMed: 27166946 MGI: J:235369
Zabel MK; Zhao L; Zhang Y; Gonzalez SR; Ma W; Wang X; Fariss RN; Wong WT. 2016. Microglial phagocytosis and activation underlying photoreceptor degeneration is regulated by CX3CL1-CX3CR1 signaling in a mouse model of retinitis pigmentosa. Glia 64(9):1479-91. PubMed: 27314452 MGI: J:234182
Zawislak CL; Beaulieu AM; Loeb GB; Karo J; Canner D; Bezman NA; Lanier LL; Rudensky AY; Sun JC. 2013. Stage-specific regulation of natural killer cell homeostasis and response against viral infection by microRNA-155. Proc Natl Acad Sci U S A 110(17):6967-72. PubMed: 23572582 MGI: J:196148
Zhang N; Schroppel B; Lal G; Jakubzick C; Mao X; Chen D; Yin N; Jessberger R; Ochando JC; Ding Y; Bromberg JS. 2009. Regulatory T cells sequentially migrate from inflamed tissues to draining lymph nodes to suppress the alloimmune response. Immunity 30(3):458-69. PubMed: 19303390 MGI: J:147032
Zhao J; Chen M; Xu H. 2014. Experimental autoimmune uveoretinitis (EAU)-related tissue damage and angiogenesis is reduced in CCL2(-)/(-)CX(3)CR1gfp/gfp mice. Invest Ophthalmol Vis Sci 55(11):7572-82. PubMed: 25342612 MGI: J:230310
Zhao L; Ma W; Fariss RN; Wong WT. 2009. Retinal vascular repair and neovascularization are not dependent on CX3CR1 signaling in a model of ischemic retinopathy. Exp Eye Res 88(6):1004-13. PubMed: 19176215 MGI: J:151032
Zhao L; Zabel MK; Wang X; Ma W; Shah P; Fariss RN; Qian H; Parkhurst CN; Gan WB; Wong WT. 2015. Microglial phagocytosis of living photoreceptors contributes to inherited retinal degeneration. EMBO Mol Med 7(9):1179-97. PubMed: 26139610 MGI: J:233541
Zhao W; Lu H; Wang X; Ransohoff RM; Zhou L. 2016. CX3CR1 deficiency delays acute skeletal muscle injury repair by impairing macrophage functions. FASEB J 30(1):380-93. PubMed: 26443824 MGI: J:230848
Zhou H; Xiao J; Wu N; Liu C; Xu J; Liu F; Wu L. 2015. MicroRNA-223 Regulates the Differentiation and Function of Intestinal Dendritic Cells and Macrophages by Targeting C/EBPbeta. Cell Rep 13(6):1149-60. PubMed: 26526992 MGI: J:228968
Zieger M; Ahnelt PK; Uhrin P. 2014. CX3CL1 (fractalkine) protein expression in normal and degenerating mouse retina: in vivo studies. PLoS One 9(9):e106562. PubMed: 25191897 MGI: J:221528
Zigmond E; Varol C; Farache J; Elmaliah E; Satpathy AT; Friedlander G; Mack M; Shpigel N; Boneca IG; Murphy KM; Shakhar G; Halpern Z; Jung S. 2012. Ly6C(hi) Monocytes in the Inflamed Colon Give Rise to Proinflammatory Effector Cells and Migratory Antigen-Presenting Cells. Immunity 37(6):1076-90. PubMed: 23219392 MGI: J:191054
von Bruhl ML; Stark K; Steinhart A; Chandraratne S; Konrad I; Lorenz M; Khandoga A; Tirniceriu A; Coletti R; Kollnberger M; Byrne RA; Laitinen I; Walch A; Brill A; Pfeiler S; Manukyan D; Braun S; Lange P; Riegger J; Ware J; Eckart A; Haidari S; Rudelius M; Schulz C; Echtler K; Brinkmann V; Schwaiger M; Preissner KT; Wagner DD; Mackman N; Engelmann B; Massberg S. 2012. Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo. J Exp Med 209(4):819-35. PubMed: 22451716 MGI: J:183864

Also Known As: CX3CR1-GFP

Donating Investigator

Genetic overview

Research Applications

Base Price

Detailed Description

Development

Expression Data

Control Suggestions

Approximate Controls

Additional Information

Selected References

Cx3cr1tm1Litt

Allele Symbol: Cx3cr1tm1Litt

Disease Terms

Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: GFP related

Mammalian Phenotype Terms by Genotype

Genotype: Cx3cr1tm1Litt/Cx3cr1+B6.129P2-Cx3cr1tm1Litt

nervous system phenotype

immune system phenotype

behavior/neurological phenotype

hematopoietic system phenotype

Genotype: Cx3cr1tm1Litt/Cx3cr1tm1LittB6.129P-Cx3cr1tm1Litt/J

homeostasis/metabolism phenotype

Genotype: Cx3cr1tm1Litt/Cx3cr1tm1LittB6.129P2-Cx3cr1tm1Litt

mortality/aging

nervous system phenotype

immune system phenotype

cardiovascular system phenotype

homeostasis/metabolism phenotype

behavior/neurological phenotype

hematopoietic system phenotype

muscle phenotype

cellular phenotype

Genotype: Cx3cr1tm1Litt/Cx3cr1tm1Littinvolves: 129P2/OlaHsd * C57BL/6

immune system phenotype

homeostasis/metabolism phenotype

vision/eye phenotype

renal/urinary system phenotype

nervous system phenotype

cardiovascular system phenotype

hematopoietic system phenotype

cellular phenotype

Genotype: Cx3cr1tm1Litt/Cx3cr1tm1LittC.129P2-Cx3cr1tm1Litt

immune system phenotype

Genotype: Cx3cr1tm1Litt/Cx3cr1tm1Littinvolves: 129P2/OlaHsd

mortality/aging

immune system phenotype

digestive/alimentary phenotype

hematopoietic system phenotype

References

Additional - Cx3cr1tm1Litt related

Genotyping Protocols

Dietary Information

Breeding Considerations

Mating System

Animal Health Reports

Live Mouse

Cryorecovery - Pricing

Progeny testing is not required

RELATED PRODUCTS AND SERVICES

Payment Terms and Conditions

The Jackson Laboratory's Genotype Promise

Terms of Use

Additional Use Restrictions Apply

Licensing Information

JAX® Mice, Products & Services Conditions of Use

No Warranty

Credit for PRODUCTS or SERVICES

Animal Care and Use for SERVICES

No Liability

Cx3cr1^tm1Litt

Allele Symbol: Cx3cr1^tm1Litt

Genotype: Cx3cr1^tm1Litt/Cx3cr1⁺
B6.129P2-Cx3cr1^tm1Litt

Genotype: Cx3cr1^tm1Litt/Cx3cr1^tm1Litt
B6.129P-Cx3cr1^tm1Litt/J

Genotype: Cx3cr1^tm1Litt/Cx3cr1^tm1Litt
B6.129P2-Cx3cr1^tm1Litt

Genotype: Cx3cr1^tm1Litt/Cx3cr1^tm1Litt
involves: 129P2/OlaHsd * C57BL/6

Genotype: Cx3cr1^tm1Litt/Cx3cr1^tm1Litt
C.129P2-Cx3cr1^tm1Litt

Genotype: Cx3cr1^tm1Litt/Cx3cr1^tm1Litt
involves: 129P2/OlaHsd

Additional - Cx3cr1^tm1Litt related