These mice carry a spontaneous re-mutation of the chocolate-like (chtl) gene that affects coat color.
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous | chtl | chocolate-like |
Mice homozygous for this spontaneous recessive mutation are recognized by a diluted coat color that appears chocolate brown. This color dilution also lightens the eyes, feet, ears, and tail of affected animals.
The chtl2J re-mutation of chtl arose spontaneously on the B6.V-Lepob/J strain at The Jackson Laboratory in 1997 when that strain was at N24F1. A chtl2J homozygous female from this intercross was bred with an unaffected sibling and homozygotes were produced. This strain has been maintained by sibling breeding homozygotes with heterozygotes, of either gender, and in 2005 reached generation F25. Obese mice (Lepob homozygotes) have never been found in this chocolate like 2 Jackson subline.
Allele Name | chocolate-like 2 Jackson |
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Allele Type | Spontaneous |
Allele Synonym(s) | |
Gene Symbol and Name | chtl, chocolate-like |
Gene Synonym(s) | |
Strain of Origin | B6.Cg-Lepob/J |
Chromosome | 7 |
General Note | Tests for allelism to cht and chtl were considered inconclusive because the F2s produced in both tests resulted in two coat colors, and while indicating some interaction between the new mutation and the chocolate mutation, does not prove that the new mutation is a remutation to chocolate. |
Molecular Note | This spontaneous mutation occurred at The Jackson Laboratory. |
When using the Chocolate-like(2J) mouse strain in a publication, please cite the originating article(s) and include JAX stock #005565 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Heterozygous or Homozygous for chtl<2J>, 1 pair minimum |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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