Overview

This strain is extinct. Please search JAX^® Mice Database for other alleles of Hps6.

Genetic overview

Genetic Background	Generation

Hps6^ru-7J

Allele Type	Gene Symbol	Gene Name
Spontaneous	Hps6	HPS6, biogenesis of lysosomal organelles complex 2 subunit 3

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Research Applications

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Details

Detailed Description

Mice homozygous for the ruby-eye 7 Jackson mutation have ruby colored eyes and a grey coat on this predominantly C57BL/6J background.

Development

The ruby-eye 7 Jackson mutation arose spontaneously in the B6.129S4-Cd86^tm1Shr/J strain (stock #003609). This mutant subline was backcrossed once to C57BL/6J and selectively intercrossed to bred out the targeted mutation and this strain has been maintained subsequently by sibling mating.

Control Suggestions

Heterozygote from the colony

Additional Information

Considerations for Choosing Controls

Selected References

Dionne L; Ward-Bailey P; Samples R; Bronson R; Johnson K. 2008. Ruby-eye 7 Jackson (ru-7J); a new remutation in the Hps6 gene MGI Direct Data SubmissionMGI: J:133644

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Genetics

Hps6^ru-7J

Allele Symbol: Hps6^ru-7J

Allele Name	ruby-eye 7 Jackson
Allele Type	Spontaneous
Allele Synonym(s)
Gene Symbol and Name	Hps6, HPS6, biogenesis of lysosomal organelles complex 2 subunit 3
Gene Synonym(s)
Strain of Origin	B6.129S4-Cd86^tm1Shr/J
Chromosome	19
General Note	This allele is extinct as of May 22, 2009.
Molecular Note	Mice carrying this new remutation were discovered in a colony at the Jackson Laboratory.

Disease/Phenotype

Disease Terms

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Mammalian Phenotype Terms by Genotype

The following phenotype relates to a compound genotype created using this strain

Genotype: Hps6^ru-7J/Hps6^ru-7J
involves: 129S4/SvJae * C57BL/6

craniofacial phenotype

decreased ear pigmentation
- severe loss of pigment in the ear skin

vision/eye phenotype

decreased eye pigmentation
- ruby colored eyes

growth/size/body region phenotype

decreased ear pigmentation
- severe loss of pigment in the ear skin

hearing/vestibular/ear phenotype

decreased ear pigmentation
- severe loss of pigment in the ear skin

integument phenotype

decreased ear pigmentation
- severe loss of pigment in the ear skin

diluted coat color
- grey coat color

mammalian phenotype

hearing/vestibular/ear phenotype
- Normal - auditory brainstem response is normal

pigmentation phenotype

decreased ear pigmentation
- severe loss of pigment in the ear skin

diluted coat color
- grey coat color

decreased eye pigmentation
- ruby colored eyes

References

Dionne L; Ward-Bailey P; Samples R; Bronson R; Johnson K. 2008. Ruby-eye 7 Jackson (ru-7J); a new remutation in the Hps6 gene MGI Direct Data SubmissionMGI: J:133644

Additional - Hps6^ru-7J related

Technical Support

CONTACT TECHNICAL SUPPORT

Genotyping Protocols
- Genotyping resources and troubleshooting

Terms Of Use

General Terms and Conditions

Questions about Terms of Use

Licensing Information

Phone: 207-288-6470

Email: TechTran@jax.org

Genetic overview

Research Applications

Detailed Description

Development

Control Suggestions

Additional Information

Selected References

Hps6ru-7J

Allele Symbol: Hps6ru-7J

Disease Terms

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Mammalian Phenotype Terms by Genotype

Genotype: Hps6ru-7J/Hps6ru-7Jinvolves: 129S4/SvJae * C57BL/6

craniofacial phenotype

vision/eye phenotype

growth/size/body region phenotype

hearing/vestibular/ear phenotype

integument phenotype

mammalian phenotype

pigmentation phenotype

References

Additional - Hps6ru-7J related

Genotyping Protocols

Terms Of Use

Licensing Information

Hps6^ru-7J

Allele Symbol: Hps6^ru-7J

Genotype: Hps6^ru-7J/Hps6^ru-7J
involves: 129S4/SvJae * C57BL/6

Additional - Hps6^ru-7J related