growth/size/body region phenotype

• decreased body weight
  • mice weigh less than wild-type mice in the first month after birth and the difference in body weight persists for throughout their lifespan
  (MGI Ref ID J:83302)

hematopoietic system phenotype

• decreased spleen weight
  • 0.056+/-0.006 g compared to 0.070+/-0.004 g in wild-type mice
  (MGI Ref ID J:83302)

immune system phenotype

• decreased spleen weight
  • 0.056+/-0.006 g compared to 0.070+/-0.004 g in wild-type mice
  (MGI Ref ID J:83302)

mammalian phenotype

• nervous system phenotype
  • Normal - no evidence of epileptic seizures are detected
  (MGI Ref ID J:83302)

• reproductive system phenotype
  • Normal - mice have normal fertility
  (MGI Ref ID J:83302)

• vision/eye phenotype
  • Normal - mice have normal eye development
  (MGI Ref ID J:83302)

adipose tissue phenotype

• decreased percent body fat/body weight
  • 1.2% compared to 2% in wild-type mice
  (MGI Ref ID J:83302)

• decreased abdominal fat pad weight
  • abdominal fat pad weight is reduced (0.30+/-0.06 g compared to 0.56+/-0.05 g in wild-type mice)
  (MGI Ref ID J:83302)

behavior/neurological phenotype

• decreased startle reflex
  • mice startle less than wild-type mice
  (MGI Ref ID J:88027)

• hyperactivity
  • mice spend more time moving than wild-type mice
  (MGI Ref ID J:88027)
  • male mice, but not female mice, travel further and spend more time moving than wild-type mice
  (MGI Ref ID J:88027)

• abnormal anxiety-related response
  • male mice, but not female mice, exhibit fewer light-dark transitions compared to wild-type mice in a light-dark test
  (MGI Ref ID J:88027)

• abnormal behavior
  • self-injury behavior is observed
  (MGI Ref ID J:88027)
  • Normal - however, no self-injury behavior is observed when mice are single housed
  (MGI Ref ID J:88027)

• abnormal contextual conditioning behavior
  • male mice, but not female mice, display less freezing following contextual conditioning
  (MGI Ref ID J:88027)

adipose tissue phenotype

• decreased abdominal fat pad weight
  (MGI Ref ID J:138598)

growth/size/body region phenotype

• decreased body weight
  • at 12 weeks
  (MGI Ref ID J:138598)

nervous system phenotype

• decreased brain weight
  • at 12 weeks
  (MGI Ref ID J:138598)

behavior/neurological phenotype

• abnormal nest building behavior
  • 6.5 hours after introducing a paper towel to cages, only half of mice build nest compared with all wild-type mice
  (MGI Ref ID J:138598)

• abnormal social investigation
  • mice exhibit impaired sociability and response to social novelty compared with wild-type mice
  (MGI Ref ID J:138598)

• decreased vertical activity
  • mice exhibit decreased vertical activity (305+/-22 incidents compared to 499+/-60 incidences in wild-type mice)
  (MGI Ref ID J:114996)

• decreased exploration in new environment
  • mice exhibit decreased center to total distance ratio explored (0.26+/-0.01 compared to 0.33+/-0.04 in wild-type mice)
  (MGI Ref ID J:114996)

• decreased vocalization
  • only half of mice vocalize during handling compared with all wild-type mice
  (MGI Ref ID J:138598)

• abnormal social/conspecific interaction
  • Normal - however, mice exhibit normal aggression
  (MGI Ref ID J:138598)
  • mice exhibit increased dominance compared with wild-type mice
  (MGI Ref ID J:138598)

• abnormal contextual conditioning behavior
  • mice exhibit impaired contextual conditioning (12.6+/-2.5% freezing to context compared to 36.0+/-6.5 in wild-type mice)
  (MGI Ref ID J:114996)

• hyperactivity
  (MGI Ref ID J:114996)

• increased anxiety-related response
  • in an elevated plus maze
  (MGI Ref ID J:138598)

growth/size/body region phenotype

• decreased body weight
  • mice weigh even less than wild-type mice compared to Dp(11Cops3-Zfp179)1Jrl heterozygotes in the first month after birth and the difference in body weight persists for throughout their lifespan
  (MGI Ref ID J:83302)