B6.D2-Dtnbp1^sdy/LmLlpJ

Stock number: 005504
Research areas: Dermatology Research, Hematological Research, Internal/Organ Research, Mouse/Human Gene Homologs

Description

This strain is extinct, please refer to Stock No. 001594

Allele

Symbol: Dtnbp1^sdy
Name: sandy
MGI accession ID: MGI:1856628
Generation method: Spontaneous
Synonyms: Bloc1s8^sdy; Dys KO; Dys^-; sdy; sdy^-
Marker symbol: Dtnbp1
Marker name: dystrobrevin binding protein 1
Marker synonyms: 5430437B18Rik; Bloc1s8; DBND; dysbindin; HPS7; My031; sdy
Chromosome: 13
Strain of origin: DBA/2J
Molecular note: The mutation in the sandy mouse has been attributed to a deletion in the Dtnbp1 gene from intron 5 nucleotide 3701 to intron 7 nucleotide 12377. The deletion results in the loss of 52 amino acids from position 119-172 and abolishes expression of the protein. Western analysis did not detect protein in hippocampus tissue from homozygous mutant mice.