These mice carry an ENU-induced mutation characterized by ataxia.
The Jackson Laboratory cannot guarantee that cryorecovery of strains from the discontinued NIH-funded Neuroscience Mutagenesis Facility (NMF) will be successful or that the anticipated phenotype or genotype will be obtained. The cryorecovery fee for this effort will not be refunded or prorated if the recovery is unsuccessful or is in any way unsatisfactory. Genotyping will be the responsibility of the Purchaser.Read More +
These mutants are smaller than their unaffected littermates, and show intense body tremor, head nodding, and occasional hind limb spasms. The on-set of the phenotype is at 4.7 weeks of age (+/- 1.1 week; n=74); however, these behaviors intensify with age, and older mutants show intense hind limb spasms, torso swaying, at times loose their balance and fall over (trunk ataxia). When lifting the mice by their tail, hind limbs might not spread, and front limbs tend to stretch forward. Standard pathology work-up on three mutants (26 - 128 days of age) revealed no abnormalities. A colony can be maintained through regular breeding.
This phenotypic deviant was generated by ethylnitrosourea (ENU) mutagenesis in C57BL/6J males (Stock No. 000664), in the Neuroscience Mutagenesis facility at The Jackson Laboratory. Mutagenized males were crossed to C57BL/6J females; G3 descendants of the mutagenized males were selected for neurological impairment.
|Allele Name||neuroscience mutagenesis facility, 347|
|Allele Type||Chemically induced (ENU)|
|Gene Symbol and Name||nmf347, neuroscience mutagenesis facility, 347|
|Strain of Origin||C57BL/6J|
|Molecular Note||This phenotypic mutation was identified in an ENU mutagenesis screen.|