These mice carry a mutation of the Bmp5 gene that affects the morphology of the ear.
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Gene trapped (Not Applicable) | Gt(ROSA)26Sor | gene trap ROSA 26, Philippe Soriano |
Allele Type | Gene Symbol | Gene Name |
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Spontaneous | Bmp5 | bone morphogenetic protein 5 |
This strain is segregating for Gt(ROSA)26Sor.
Homozygotes have small, round ear pinnae with ridges along the perimeter and both ears are affected. This mutation is 100% penetrant. Unlike short ear mutations of this gene, skeletal abnormalities were not detected by X-ray for this mutant. Both males and females are fertile.
The cauliflower ear mutation arose spontaneously in 2002 in the production colony of C.129S7-Gt(ROSA)26Sor/J (stock #002255) at The Jackson Laboratory. The mutant subline was maintained by sibling breeding for 8 generations, then backcrossed once to BALB/cJ, and then intercrossed. In 2007 sperm were cryopreserved from homozygous Males at generation +F8N1F2.
Expressed Gene | lacZ, beta-galactosidase, E. coli |
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Site of Expression | All tissues of the developing embryo and in most tissues of the adult mouse. |
Site of Expression |
Allele Name | gene trap ROSA 26, Philippe Soriano |
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Allele Type | Gene trapped (Not Applicable) |
Allele Synonym(s) | Gt(ROSA)26Sor; gene trap ROSA 26, Philippe Soriano |
Gene Symbol and Name | Gt(ROSA)26Sor, gene trap ROSA 26, Philippe Soriano |
Gene Synonym(s) | beta geo; ROSA26; R26; Gtrgeo26; Gtrosa26; Gtrgeo26; Gtrosa26; AV258896; expressed sequence AV258896; gene trap ROSA 26; gene trap ROSA b-geo 26; SETD5-AS1; Thumpd3as1 |
Expressed Gene | lacZ, beta-galactosidase, E. coli |
Site of Expression | All tissues of the developing embryo and in most tissues of the adult mouse. |
Strain of Origin | 129S7/SvEvBrd-Hprt+ |
Chromosome | 6 |
General Note | ES cell line = AB1 or AB2.1. No overt phenotypes in heterozygous or homozygous animals. The trapped gene appears to be ubiquitously expressed during embryonic development and in all hematopoietic cells. |
Molecular Note | Random insertion of retroviral gene trap vector ROSA, Reverse Orientation with Splice Acceptor, which contains the beta-galactosidase gene and accompanying splice acceptor and neo sequences. The construct was inserted in reverse orientation in the retroviral vector pGen-. The transgene is controlled by an unknown endogenous promoter. lacZ is expressed in all tissues of the developing embryo and in most tissues of the adult transgenic mouse. |
Mutations Made By | Dr. Philippe Soriano, Mount Sinai School of Medicine |
Allele Name | cauliflower ear short ear 7 Jackson |
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Allele Type | Spontaneous |
Allele Synonym(s) | cauliflower ear short ear 7 Jackson; Bmp5cfe-se7J |
Gene Symbol and Name | Bmp5, bone morphogenetic protein 5 |
Gene Synonym(s) | AU023399; expressed sequence AU023399; se; short ear |
Strain of Origin | C.129S7-Gt(ROSA)26Sor/J |
Chromosome | 9 |
Molecular Note | The cauliflower ear mutation was found to be allelic with the short ear mutation through a noncomplementation test. |
When using the cauliflower ear 7 Jackson mouse strain in a publication, please cite the originating article(s) and include JAX stock #005420 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service | Genotype | Price |
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Heterozygous for Bmp5<cfe-se7J>, Heterozygous or Wild-type for Gt(ROSA)26Sor |
We will fulfill your order by providing at least two carriers for each strain ordered. The total number, sex, and genotypes provided will vary, although typically 8 or more animals are provided. Please check genotypes which will be recovered. While the genotypes of all animals produced will be communicated to you prior to scheduling shipment, the genotypes of animals provided may not reflect the mating scheme and genotypes described in the strain description. Animals are typically ready to ship in 11-14 weeks. If a second recovery is required to produce the minimum number of animals, then delivery time would increase to approximately 25 weeks. If we fail to produce animals of the correct genotype, you will not be charged. We cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.
Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation.
Frozen Mouse Embryo | C;129S7 Gt(ROSA)26Sor-Bmp5<cfe-se7J>/GrsrJ | $2595.00 |
Frozen Mouse Embryo | C;129S7 Gt(ROSA)26Sor-Bmp5<cfe-se7J>/GrsrJ | $2595.00 |
Frozen Mouse Embryo | C;129S7 Gt(ROSA)26Sor-Bmp5<cfe-se7J>/GrsrJ | $3373.50 |
Frozen Mouse Embryo | C;129S7 Gt(ROSA)26Sor-Bmp5<cfe-se7J>/GrsrJ | $3373.50 |
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