JAX
Mouse Strain Datasheet - 005420
C;129S7 Gt(ROSA)26Sor-Bmp5cfe-se7J/GrsrJ
Also Known As: cauliflower ear 7 Jackson
These mice carry a mutation of the Bmp5 gene that affects the morphology of the ear.
Read More +Genetic overview
| Genetic Background | Generation |
|---|---|
|
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Bmp5cfe-se7J
| Allele Type | Gene Symbol | Gene Name |
|---|---|---|
| Spontaneous | Bmp5 | bone morphogenetic protein 5 |
Gt(ROSA)26Sor
| Allele Type | Gene Symbol | Gene Name |
|---|---|---|
| Gene trapped (Not Applicable) | Gt(ROSA)26Sor | gene trap ROSA 26, Philippe Soriano |
Important Note
This strain is segregating for Gt(ROSA)26Sor.
Detailed Description
Homozygotes have small, round ear pinnae with ridges along the perimeter and both ears are affected. This mutation is 100% penetrant. Unlike short ear mutations of this gene, skeletal abnormalities were not detected by X-ray for this mutant. Both males and females are fertile.
Development
The cauliflower ear mutation arose spontaneously in 2002 in the production colony of C.129S7-Gt(ROSA)26Sor/J (stock #002255) at The Jackson Laboratory. The mutant subline was maintained by sibling breeding for 8 generations, then backcrossed once to BALB/cJ, and then intercrossed. In 2007 sperm were cryopreserved from homozygous Males at generation +F8N1F2.
Expression Data
| Expressed Gene | lacZ, beta-galactosidase, E. coli |
|---|---|
| Site of Expression | All tissues of the developing embryo and in most tissues of the adult mouse. |
Bmp5cfe-se7J
Allele Symbol: Bmp5cfe-se7J
| Allele Name | cauliflower ear short ear 7 Jackson |
|---|---|
| Allele Type | Spontaneous |
| Allele Synonym(s) | |
| Gene Symbol and Name | Bmp5, bone morphogenetic protein 5 |
| Gene Synonym(s) | AU023399; expressed sequence AU023399; se; short ear |
| Strain of Origin | C.129S7-Gt(ROSA)26Sor/J |
| Chromosome | 9 |
| Molecular Note | The cauliflower ear mutation was found to be allelic with the short ear mutation through a noncomplementation test. |
Gt(ROSA)26Sor
Allele Symbol: Gt(ROSA)26Sor
| Allele Name | gene trap ROSA 26, Philippe Soriano |
|---|---|
| Allele Type | Gene trapped (Not Applicable) |
| Allele Synonym(s) | R26tg; R26R3; ROSA26; ROSA26-lacZ; Rosa26lacZ; TgR(ROSA26)26Sor; gtrosa26 |
| Gene Symbol and Name | Gt(ROSA)26Sor, gene trap ROSA 26, Philippe Soriano |
| Gene Synonym(s) | AV258896; Gtrgeo26; Gtrgeo26; Gtrosa26; Gtrosa26; R26; ROSA26; SETD5-AS1; Thumpd3as1; beta geo; expressed sequence AV258896; gene trap ROSA 26; gene trap ROSA b-geo 26 |
| Expressed Gene | lacZ, beta-galactosidase, E. coli |
| Site of Expression | All tissues of the developing embryo and in most tissues of the adult mouse. |
| Strain of Origin | 129S7/SvEvBrd-Hprt<+> |
| Chromosome | 6 |
| General Note | ES cell line = AB1 or AB2.1. No overt phenotypes in heterozygous or homozygous animals. The trapped gene appears to be ubiquitously expressed during embryonic development and in all hematopoietic cells. |
| Molecular Note | Random insertion of retroviral gene trap vector ROSA, Reverse Orientation with Splice Acceptor, which contains the beta-galactosidase gene and accompanying splice acceptor and neo sequences. The construct was inserted in reverse orientation in the retroviral vector pGen-. The transgene is controlled by an unknown endogenous promoter. lacZ is expressed in all tissues of the developing embryo and in most tissues of the adult transgenic mouse. |
| Mutations Made By | Dr. Philippe Soriano, Mount Sinai School of Medicine |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
Genotype: Bmp5cfe-se7J related
- Developmental Biology Research
- Craniofacial and Palate Defects
Mammalian Phenotype Terms by Genotype
The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain
Genotype: Bmp5cfe-se7J/Bmp5cfe-se7J
involves: 129S7/SvEvBrd * BALB/cJ
craniofacial phenotype
- abnormal cranium morphology
- male homozygotes have greater skull height than controls, but female homozygotes have a statistically insignificant decrease in skull height (MGI Ref ID J:123049)
- the skull height to skull length ratio is increased in males (MGI Ref ID J:123049)
- the skull height to skull width ratio is increased in males (MGI Ref ID J:123049)
- the skull length to nose length ratio is decreased in females (MGI Ref ID J:123049)
- the skull length to skull width ratio is decreased in both males and females (MGI Ref ID J:123049)
- abnormal cranium size
- slight but significant decrease in the skull length to width ratio (MGI Ref ID J:223062)
- abnormal ear shape
- both ears are smaller than normal and have round ear pinnae with ridges around the perimeter (MGI Ref ID J:123049)
- abnormal nose morphology
- females have shorter nose lengths than controls, but the shortened nose lenghts of male homozygotes was not found statistically significant (MGI Ref ID J:123049)
- decreased cranium height
- males and females have shorter skull lengths than do controls (MGI Ref ID J:123049)
- decreased cranium length
- slightly smaller skull length in both males and females (MGI Ref ID J:223062)
- lowered ear position
- (MGI Ref ID J:123049)
- short ears
- both females and males have ear lobes that are approximately half normal length (MGI Ref ID J:223062)
- short mandible
- short maxilla
- shortened upper jaw length is statistically significant in males, but not statistically significant in females (MGI Ref ID J:123049)
- short snout
skeleton phenotype
- abnormal cranium morphology
- male homozygotes have greater skull height than controls, but female homozygotes have a statistically insignificant decrease in skull height (MGI Ref ID J:123049)
- the skull height to skull length ratio is increased in males (MGI Ref ID J:123049)
- the skull height to skull width ratio is increased in males (MGI Ref ID J:123049)
- the skull length to nose length ratio is decreased in females (MGI Ref ID J:123049)
- the skull length to skull width ratio is decreased in both males and females (MGI Ref ID J:123049)
- abnormal cranium size
- slight but significant decrease in the skull length to width ratio (MGI Ref ID J:223062)
- decreased areal bone mineral density
- (MGI Ref ID J:223062)
- decreased bone mineral content
- statistically slightly lower in both females and males (MGI Ref ID J:223062)
- decreased bone mineral density
- whole body bone mineral density is decreased in both females and males (MGI Ref ID J:123049)
- decreased cranium height
- males and females have shorter skull lengths than do controls (MGI Ref ID J:123049)
- decreased cranium length
- slightly smaller skull length in both males and females (MGI Ref ID J:223062)
- short mandible
- short maxilla
- shortened upper jaw length is statistically significant in males, but not statistically significant in females (MGI Ref ID J:123049)
- skeleton phenotype
- no abnormality was found in spine length, ratios of tail length to back length, femur length to back length or spine length to back length (MGI Ref ID J:123049)
hearing/vestibular/ear phenotype
- abnormal ear shape
- both ears are smaller than normal and have round ear pinnae with ridges around the perimeter (MGI Ref ID J:123049)
- hearing/vestibular/ear phenotype
- ABR threshold analysis at three months of age indicates normal hearing (MGI Ref ID J:123049)
- lowered ear position
- (MGI Ref ID J:123049)
- short ears
- both females and males have ear lobes that are approximately half normal length (MGI Ref ID J:223062)
respiratory system phenotype
- abnormal nose morphology
- females have shorter nose lengths than controls, but the shortened nose lenghts of male homozygotes was not found statistically significant (MGI Ref ID J:123049)
growth/size/body region phenotype
- abnormal ear shape
- both ears are smaller than normal and have round ear pinnae with ridges around the perimeter (MGI Ref ID J:123049)
- abnormal nose morphology
- females have shorter nose lengths than controls, but the shortened nose lenghts of male homozygotes was not found statistically significant (MGI Ref ID J:123049)
- lowered ear position
- (MGI Ref ID J:123049)
- short ears
- both females and males have ear lobes that are approximately half normal length (MGI Ref ID J:223062)
References
Additional - Bmp5cfe-se7J related
- Giggey J; Bauschatz J; Curtain M; Donahue LR. 2007. Cauliflower Ear, a Remutation to Bmp5. In: . . MGI: J:123049
- Palmer K; Fairfield H; Borgeia S; Curtain M; Hassan MG; Dionne L; Yong Karst S; Coombs H; Bronson RT; Reinholdt LG; Bergstrom DE; Donahue LR; Cox TC; Murray SA. 2016. Discovery and characterization of spontaneous mouse models of craniofacial dysmorphology.. In: . . MGI: J:223062
Additional - Gt(ROSA)26Sor related
- Aghi M; Cohen KS; Klein RJ; Scadden DT; Chiocca EA. 2006. Tumor stromal-derived factor-1 recruits vascular progenitors to mitotic neovasculature, where microenvironment influences their differentiated phenotypes.. In: . . MGI: J:112935
- Ahn GO; Brown JM. 2008. Matrix metalloproteinase-9 is required for tumor vasculogenesis but not for angiogenesis: role of bone marrow-derived myelomonocytic cells.. In: . . MGI: J:132946
- Ando S; Abe R; Sasaki M; Murata J; Inokuma D; Shimizu H. 2009. Bone marrow-derived cells are not the origin of the cancer stem cells in ultraviolet-induced skin cancer.. In: . . MGI: J:144196
- Anthony TE; Klein C; Fishell G; Heintz N. 2004. Radial glia serve as neuronal progenitors in all regions of the central nervous system.. In: . . MGI: J:89775
- Arnold K; Sarkar A; Yram MA; Polo JM; Bronson R; Sengupta S; Seandel M; Geijsen N; Hochedlinger K. 2011. Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice.. In: . . MGI: J:177655
- Arnold SJ; Hofmann UK; Bikoff EK; Robertson EJ. 2008. Pivotal roles for eomesodermin during axis formation, epithelium-to-mesenchyme transition and endoderm specification in the mouse.. In: . . MGI: J:131055
- Arruda-Carvalho M; Akers KG; Guskjolen A; Sakaguchi M; Josselyn SA; Frankland PW. 2014. Posttraining ablation of adult-generated olfactory granule cells degrades odor-reward memories.. In: . . MGI: J:218199
- Arruda-Carvalho M; Sakaguchi M; Akers KG; Josselyn SA; Frankland PW. 2011. Posttraining ablation of adult-generated neurons degrades previously acquired memories.. In: . . MGI: J:177636
- Baba M; Furihata M; Hong SB; Tessarollo L; Haines DC; Southon E; Patel V; Igarashi P; Alvord WG; Leighty R; Yao M; Bernardo M; Ileva L; Choyke P; Warren MB; Zbar B; Linehan WM; Schmidt LS. 2008. Kidney-targeted Birt-Hogg-Dube gene inactivation in a mouse model: Erk1/2 and Akt-mTOR activation, cell hyperproliferation, and polycystic kidneys.. In: . . MGI: J:130978
- Babaev VR; Yancey PG; Ryzhov SV; Kon V; Breyer MD; Magnuson MA; Fazio S; Linton MF. 2005. Conditional knockout of macrophage PPARgamma increases atherosclerosis in C57BL/6 and low-density lipoprotein receptor-deficient mice.. In: . . MGI: J:114332
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- Bianco C; Cotten C; Lonardo E; Strizzi L; Baraty C; Mancino M; Gonzales M; Watanabe K; Nagaoka T; Berry C; Arai AE; Minchiotti G; Salomon DS. 2009. Cripto-1 is required for hypoxia to induce cardiac differentiation of mouse embryonic stem cells.. In: . . MGI: J:154688
- Bosman EA; Lawson KA; Debruyn J; Beek L; Francis A; Schoonjans L; Huylebroeck D; Zwijsen A. 2006. Smad5 determines murine amnion fate through the control of bone morphogenetic protein expression and signalling levels.. In: . . MGI: J:112229
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- Chi L; Itaranta P; Zhang S; Vainio S. 2006. Sprouty2 is involved in male sex organogenesis by controlling fibroblast growth factor 9-induced mesonephric cell migration to the developing testis.. In: . . MGI: J:129651
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- Croyle MJ; Lehman JM; O'Connor AK; Wong SY; Malarkey EB; Iribarne D; Dowdle WE; Schoeb TR; Verney ZM; Athar M; Michaud EJ; Reiter JF; Yoder BK. 2011. Role of epidermal primary cilia in the homeostasis of skin and hair follicles.. In: . . MGI: J:171221
- Cuttler AS; Leclair RJ; Stohn JP; Wang Q; Sorenson CM; Liaw L; Lindner V. 2011. Characterization of Pdgfrb-Cre transgenic mice reveals reduction of ROSA26 reporter activity in remodeling arteries.. In: . . MGI: J:175492
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- Helsel AR; Yang QE; Oatley MJ; Lord T; Sablitzky F; Oatley JM. 2017. ID4 levels dictate the stem cell state in mouse spermatogonia.. In: . . MGI: J:239157
- Hirai H; Verma M; Watanabe S; Tastad C; Asakura Y; Asakura A. 2010. MyoD regulates apoptosis of myoblasts through microRNA-mediated down-regulation of Pax3.. In: . . MGI: J:165481
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- Hsu W; Mirando AJ; Yu HM. 2009. Manipulating gene activity in Wnt1-expressing precursors of neural epithelial and neural crest cells.. In: . . MGI: J:155252
- Humphreys BD; Lin SL; Kobayashi A; Hudson TE; Nowlin BT; Bonventre JV; Valerius MT; McMahon AP; Duffield JS. 2010. Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis.. In: . . MGI: J:158051
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- Jager R; Maurer J; Jacob A; Schorle H. 2004. Cell type-specific conditional regulation of the c-myc proto-oncogene by combining Cre/loxP recombination and tamoxifen-mediated activation.. In: . . MGI: J:89756
- Kitajima S; Takagi A; Inoue T; Saga Y. 2000. MesP1 and MesP2 are essential for the development of cardiac mesoderm.. In: . . MGI: J:62984
- Kleaveland B; Zheng X; Liu JJ; Blum Y; Tung JJ; Zou Z; Chen M; Guo L; Lu MM; Zhou D; Kitajewski J; Affolter M; Ginsberg MH; Kahn ML. 2009. Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway.. In: . . MGI: J:146528
- Kobayashi A; Valerius MT; Mugford JW; Carroll TJ; Self M; Oliver G; McMahon AP. 2008. Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development.. In: . . MGI: J:148455
- Kohlhepp RL; Hegge LF; Moser AR. 2001. The ROSA26 LacZ-neoR insertion confers resistance to mammary tumors in ApcMin/+ mice.. In: . . MGI: J:70825
- Kohlhepp RL; Hegge LF; Nett JE; Moser AR. 2000. ROSA26 mice carry a modifier of Min-induced mammary and intestinal tumor development.. In: . . MGI: J:66060
- Kubota H; Avarbock MR; Schmidt JA; Brinster RL. 2009. Spermatogonial stem cells derived from infertile Wv/Wv mice self-renew in vitro and generate progeny following transplantation.. In: . . MGI: J:152976
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- Li Z; Chen MJ; Stacy T; Speck NA. 2006. Runx1 function in hematopoiesis is required in cells that express Tek.. In: . . MGI: J:125796
- Lugus JJ; Park C; Ma YD; Choi K. 2009. Both primitive and definitive blood cells are derived from Flk-1+ mesoderm.. In: . . MGI: J:144056
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- Mukouyama YS; Deneen B; Lukaszewicz A; Novitch BG; Wichterle H; Jessell TM; Anderson DJ. 2006. Olig2+ neuroepithelial motoneuron progenitors are not multipotent stem cells in vivo.. In: . . MGI: J:142333
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