RHJ/LeJ-Krt27^stpm/GrsrJ

Stock number: 005415
Product name: short term perm

Description

Mice carrying this spontaneous mutation of the Krt27 gene are characterized by having very curly coats and slightly curved vibrissae.

Detailed description

The phenotype of this mutation can be identified by a curly coat, which is different from the smooth coat of control littermates. At 3 weeks of age, mice homozygous for this new mutation have very curly coats and slightly curved vibrissae. In several weeks time the curly coat disappears but the hair retains a rough texture, and the vibrissae then appear normal. Heterozygous mice have normal smooth coats and straight whiskers.

Development

The short term perm mutation arose spontaneously on the RHJ/LeJ background at The Jackson Laboratory in 1998 when that strain was at F121. This mutant substrain was subsequently maintained by sibling mating primarily heterozygotes with homozygotes and vice versa. The recessive rhino mutation has never been seen in this substrain although it had to have been present heterozygously in the founders. In 2005 this strain reached F121+F23.

Allele

Symbol: Krt27^stpm
Name: short term perm
MGI accession ID: MGI:3522000
Generation method: Spontaneous
Marker symbol: Krt27
Marker name: keratin 27
Marker synonyms: K25IRS3; Ka40; Krt1-c29; KRT25C; mIRSa3.1; stpm
Chromosome: 11
Strain of origin: RHJ/LeJ
Molecular note: This spontaneous mutation arose at The Jackson Laboratory. A T-to-C point mutation at coding nucleotide 965 of the cDNA (NM_010666) results in a leucine to proline substitution at position 322 of the encoded protein (p.L322P).