The phenotype of this mutation can be identified by a curly coat, which is different from the smooth coat of control littermates. At 3 weeks of age, mice homozygous for this new mutation have very curly coats and slightly curved vibrissae. In several weeks time the curly coat disappears but the hair retains a rough texture, and the vibrissae then appear normal. Heterozygous mice have normal smooth coats and straight whiskers.
The short term perm mutation arose spontaneously on the RHJ/LeJ background at The Jackson Laboratory in 1998 when that strain was at F121. This mutant substrain was subsequently maintained by sibling mating primarily heterozygotes with homozygotes and vice versa. The recessive rhino mutation has never been seen in this substrain although it had to have been present heterozygously in the founders. In 2005 this strain reached F121+F23.
|Allele Name||short term perm|
|Gene Symbol and Name||Krt27, keratin 27|
|Strain of Origin||RHJ/LeJ|
|Molecular Note||This spontaneous mutation arose at The Jackson Laboratory. A T-to-C point mutation at coding nucleotide 965 of the cDNA (NM_010666) results in a leucine to proline substitution at position 322 of the encoded protein (p.L322P).|
When using the short term perm mouse strain in a publication, please cite the originating article(s) and include JAX stock #005415 in your Materials and Methods section.