Mice carrying this spontaneous mutation of the Fgfr1 gene are characterized by hearing loss.
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous | Fgfr1 | fibroblast growth factor receptor 1 |
The ear askew mutation is homozygous embryonic lethal. Heterozygotes have unilateral or bilateral low-set ears and malformed pinna. There is variable expressivity. Heterozygotes are viable and fertile, but auditory brainstem response assessment shows severe hearing loss at 6 months of age.
The ear askew mutation arose spontaneously in the strain BALB/cByJ-Agtpbppcd-3J/J at The Jackson Laboratory in 2001. This mutant subline has been maintained by sibling intercrossing heterozygotes with wild-type siblings and the -Agtpbppcd-3J mutation was bred out. In 2009 his strain reached generation +F16 and sperm was cryopreserved from heterozygous males.
Allele Name | ear askew |
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Allele Type | Spontaneous |
Allele Synonym(s) | |
Gene Symbol and Name | Fgfr1, fibroblast growth factor receptor 1 |
Gene Synonym(s) | |
Strain of Origin | BALB/cByJ-Agtpbp1pcd-3J/J |
Chromosome | 8 |
Molecular Note | This spontaneous point mutation is a C-to-G transversion at position 25,557,813 (GRCm38) that results in an asparagine to lysine substitution at amino acid 147 (p.N147K). |
When using the ear askew mouse strain in a publication, please cite the originating article(s) and include JAX stock #005412 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous or Wildtype for Eask |
Frozen Mouse Embryo | BALB/cByJ-Fgfr1<Eask>/GrsrJ | $2595.00 |
Frozen Mouse Embryo | BALB/cByJ-Fgfr1<Eask>/GrsrJ | $2595.00 |
Frozen Mouse Embryo | BALB/cByJ-Fgfr1<Eask>/GrsrJ | $3373.50 |
Frozen Mouse Embryo | BALB/cByJ-Fgfr1<Eask>/GrsrJ | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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