JAX Mouse Strain Datasheet - 005346

NOD.Cg-Il10^tm1Cgn Casp1^tm1Sesh Casp4^del/LtJ

Stock No:: 005346 |; NOD-IL1-10^null/Casp1^null

Cryo Recovery

Overview

Also Known As: NOD-IL1-10^null/Casp1^null

These mice carry a double knock-out along with a deletion; they develop type 1 diabetes and are susceptible to colitis.

Donating Investigator

Dr. Edward Leiter, The Jackson Laboratory

Genetic overview

Genetic Background	Generation
001289 NOD/ShiLt

Casp1^tm1Sesh

Allele Type	Gene Symbol	Gene Name
Targeted (Null/Knockout)	Casp1	caspase 1

Casp4^del

Allele Type	Gene Symbol	Gene Name
Spontaneous	Casp4	caspase 4, apoptosis-related cysteine peptidase

Allele Type	Gene Symbol	Gene Name
Targeted (Null/Knockout)	Il10	interleukin 10

Research Applications

Cancer Research
Diabetes and Obesity Research
Immunology, Inflammation and Autoimmunity Research
Internal/Organ Research
Research Tools
Hematological Research

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Base Price

Starting at:

$2,595.00 Domestic price Cryo Recovery

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Details

Detailed Description

Mice homozygous for the Il10 and Casp1 targeted mutations are viable and fertile when housed under SPF conditions. NOD/Lt mice deficient for both of these genes develop type 1 diabetes at a rate equivalent to the parental strains. The Il10 targeted mutation also renders this NOD/Lt stock susceptible to colitis (although not as severe as other strains of Il10 deficient mice) when maintained under standard housing conditions.

Development

For details related to the construction of each allele, please refer to the entries for strains 004947 and 004266. NOD.Il10 homozygous mice were crossed to NOD.Casp1 homozygous mice prior to making homozygous for both alleles. In 2006, the T1DR received double homozygous mice at generation F16.

Control Suggestions

None Available

Additional Information

Considerations for Choosing Controls

Genetics

Casp1^tm1Sesh

Allele Symbol: Casp1^tm1Sesh

Allele Name	targeted mutation 1, Tara Seshadri
Allele Type	Targeted (Null/Knockout)
Allele Synonym(s)	Casp1 -; Casp1^-/Casp11^129mt; Caspase-1-; ICE -; casp-1^-
Gene Symbol and Name	Casp1, caspase 1
Gene Synonym(s)	Caspase-1; ICE; IL1BC; Ice; Il1bc; Il1bc; P45; interleukin 1 beta convertase; interleukin 1 beta-converting enzyme
Strain of Origin	129S2/SvPas
Chromosome	9
General Note	The ES cells used to generate this allele contain the linked Casp4^del truncated allele that fails to produce a functional Casp4. Phenotypes associated with this allele may be affected by the presence of the Casp^del allele. J:193522
Molecular Note	A neomycin expression cassette was inserted into exon 6, deleting 31 bp of sequence encoding the region of the active site and rendering the sequence out of frame after the insertion. Northern blot analysis on spleen RNA demonstrated an absence of the normal transcript in homozygous mice, and western blot analysis showed that the protein was not expressed in peritoneal macrophages of homozygous mice. This allele was generated in ES cells that lack protein expression of Casp11 (Casp^129mt).
Mutations Made By	Dr. Edward Leiter, The Jackson Laboratory

Casp4^del

Allele Symbol: Casp4^del

Allele Name	deletion
Allele Type	Spontaneous
Allele Synonym(s)	Casp¹²⁹
Gene Symbol and Name	Casp4, caspase 4, apoptosis-related cysteine peptidase
Gene Synonym(s)	Casp11; Casp11; Caspase-11; ICE(rel)II; ICEREL-II; ICH-2; Mih1; Mih1/TX; TX; capase 11, apoptosis-related cysteine protease; caspase 11, apoptosis-related cysteine peptidase; ich-3
Strain of Origin	129P3/J and 129S1/SvImJ and 129S2/SvPas and 129S6/SvEvTac and 129X1/SvJ
Chromosome	9
Molecular Note	RT-PCR confirmed that five 129 substrains (129X1/SvJ, 129S1/SvImJ, 129S2/SvPas, 129S6/SvEvTac and 129P3/J) express a transcript that lacks exon 7 (delta110 isoform). Sequencing identified a 5 bp deletion in exon 7 that results in the fusion of exon 6 and 8, a frame-shift after proline 304 and a stop codon after 5 aberrant amino acids. This deletion is not present in C57BL/6. Western blot analysis confirmed the absence of protein expression in LPS-primed macrophage.

Il10^tm1Cgn

Allele Symbol: Il10^tm1Cgn

Allele Name	targeted mutation 1, University of Cologne
Allele Type	Targeted (Null/Knockout)
Allele Synonym(s)	IL-10 KO; IL-10-; IL-10^KO; IL-10KO; Il10-; Il10^tmCgn
Gene Symbol and Name	Il10, interleukin 10
Gene Synonym(s)	CSIF; GVHDS; IL-10; IL10A; IL10X; Il-10; TGIF; cytokine synthesis inhibitory factor
Strain of Origin	129P2/OlaHsd
Chromosome	1
Molecular Note	A 500 bp genomic fragment containing codons 5-55 was replaced with a linker containing a termination codon followed by a neomycin cassette. A termination codon was also introduced into exon 3. No IL10 activity was detectable by ELISA assays in supernatants of in vitro cultures of Con A-stimulated splenic T cells derived from homozygous mice following infection with the nematode N. brasiliensis.
Mutations Made By	Dr. Ralf Kuhn, University of Cologne

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Cancer Research
- Growth Factors/Receptors/Cytokines
Diabetes and Obesity Research
- Type 1 Diabetes (IDDM) Analysis Strains
  - NOD Congenics with Mutations Affecting Cytokine Production by Autoreactive T Cells
- Type 1 Diabetes (IDDM)
  - Congenics with mutations affecting cytokine production by autoreactive T cells
Immunology, Inflammation and Autoimmunity Research
- Growth Factors/Receptors/Cytokines
  - control strain
Internal/Organ Research
- Gastrointestinal Defects
  - colitis

Genotype: Casp1^tm1Sesh related

Diabetes and Obesity Research
- Type 1 Diabetes (IDDM)
Immunology, Inflammation and Autoimmunity Research
- Immunodeficiency
  - B cell defects
Research Tools
- Diabetes and Obesity Research

Genotype: Il10^tm1Cgn related

Cancer Research
- Growth Factors/Receptors/Cytokines
Hematological Research
- Anemia, Iron Deficiency and Transport Defects
  - hemolytic
- Immunological Defects
Immunology, Inflammation and Autoimmunity Research
- Autoimmunity
- Growth Factors/Receptors/Cytokines
- Immunodeficiency
- Inflammation
  - Inflammatory bowel disease

References

Additional - Casp1^tm1Sesh related

Aachoui Y; Kajiwara Y; Leaf IA; Mao D; Ting JP; Coers J; Aderem A; Buxbaum JD; Miao EA. 2015. Canonical Inflammasomes Drive IFN-gamma to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium.. In: . . MGI: J:243015
Aachoui Y; Leaf IA; Hagar JA; Fontana MF; Campos CG; Zak DE; Tan MH; Cotter PA; Vance RE; Aderem A; Miao EA. 2013. Caspase-11 protects against bacteria that escape the vacuole.. In: . . MGI: J:193387
Anthony DA; Andrews DM; Chow M; Watt SV; House C; Akira S; Bird PI; Trapani JA; Smyth MJ. 2010. A role for granzyme M in TLR4-driven inflammation and endotoxicosis.. In: . . MGI: J:162467
Antonopoulos C; Cumberbatch M; Dearman RJ; Daniel RJ; Kimber I; Groves RW. 2001. Functional caspase-1 is required for Langerhans cell migration and optimal contact sensitization in mice.. In: . . MGI: J:124939
Antonopoulos C; Cumberbatch M; Mee JB; Dearman RJ; Wei XQ; Liew FY; Kimber I; Groves RW. 2008. IL-18 is a key proximal mediator of contact hypersensitivity and allergen-induced Langerhans cell migration in murine epidermis.. In: . . MGI: J:145093
Antonopoulos C; El Sanadi C; Kaiser WJ; Mocarski ES; Dubyak GR. 2013. Proapoptotic chemotherapeutic drugs induce noncanonical processing and release of IL-1beta via caspase-8 in dendritic cells.. In: . . MGI: J:206238
Antonopoulos C; Russo HM; El Sanadi C; Martin BN; Li X; Kaiser WJ; Mocarski ES; Dubyak GR. 2015. Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome Signaling.. In: . . MGI: J:224602
Barry KC; Fontana MF; Portman JL; Dugan AS; Vance RE. 2013. IL-1alpha signaling initiates the inflammatory response to virulent Legionella pneumophila in vivo.. In: . . MGI: J:204844
Birchenough GM; Nystrom EE; Johansson ME; Hansson GC. 2016. A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion.. In: . . MGI: J:233302
Boyden ED; Dietrich WF. 2006. Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin. In: . . MGI: J:99748
Chamberlain J; Evans D; King A; Dewberry R; Dower S; Crossman D; Francis S. 2006. Interleukin-1beta and signaling of interleukin-1 in vascular wall and circulating cells modulates the extent of neointima formation in mice.. In: . . MGI: J:107324
Cheng W; Shivshankar P; Li Z; Chen L; Yeh IT; Zhong G. 2008. Caspase-1 contributes to Chlamydia trachomatis-induced upper urogenital tract inflammatory pathologies without affecting the course of infection.. In: . . MGI: J:130235
Cieniewicz B; Dong Q; Li G; Forrest JC; Mounce BC; Tarakanova VL; van der Velden A; Krug LT. 2015. Murine Gammaherpesvirus 68 Pathogenesis Is Independent of Caspase-1 and Caspase-11 in Mice and Impairs Interleukin-1beta Production upon Extrinsic Stimulation in Culture.. In: . . MGI: J:222863
Coers J; Vance RE; Fontana MF; Dietrich WF. 2007. Restriction of Legionella pneumophila growth in macrophages requires the concerted action of cytokine and Naip5/Ipaf signalling pathways.. In: . . MGI: J:148669
Csoka B; Nemeth ZH; Toro G; Idzko M; Zech A; Koscso B; Spolarics Z; Antonioli L; Cseri K; Erdelyi K; Pacher P; Hasko G. 2015. Extracellular ATP protects against sepsis through macrophage P2X7 purinergic receptors by enhancing intracellular bacterial killing.. In: . . MGI: J:225524
Cumberbatch M; Dearman RJ; Antonopoulos C; Groves RW; Kimber I. 2001. Interleukin (IL)-18 induces Langerhans cell migration by a tumour necrosis factor-alpha- and IL-1beta-dependent mechanism.. In: . . MGI: J:68644
Cunha LD; Ribeiro JM; Fernandes TD; Massis LM; Khoo CA; Moffatt JH; Newton HJ; Roy CR; Zamboni DS. 2015. Inhibition of inflammasome activation by Coxiella burnetii type IV secretion system effector IcaA.. In: . . MGI: J:228423
Desbien AL; Reed SJ; Bailor HR; Dubois Cauwelaert N; Laurance JD; Orr MT; Fox CB; Carter D; Reed SG; Duthie MS. 2015. Squalene emulsion potentiates the adjuvant activity of the TLR4 agonist, GLA, via inflammatory caspases, IL-18, and IFN-gamma.. In: . . MGI: J:222315
Dewamitta SR; Nomura T; Kawamura I; Hara H; Tsuchiya K; Kurenuma T; Shen Y; Daim S; Yamamoto T; Qu H; Sakai S; Xu Y; Mitsuyama M. 2010. Listeriolysin O-dependent bacterial entry into the cytoplasm is required for calpain activation and interleukin-1 alpha secretion in macrophages infected with Listeria monocytogenes.. In: . . MGI: J:160087
Dixon LJ; Flask CA; Papouchado BG; Feldstein AE; Nagy LE. 2013. Caspase-1 as a central regulator of high fat diet-induced non-alcoholic steatohepatitis.. In: . . MGI: J:198314
Dorhoi A; Nouailles G; Jorg S; Hagens K; Heinemann E; Pradl L; Oberbeck-Muller D; Duque-Correa MA; Reece ST; Ruland J; Brosch R; Tschopp J; Gross O; Kaufmann SH. 2012. Activation of the NLRP3 inflammasome by Mycobacterium tuberculosis is uncoupled from susceptibility to active tuberculosis.. In: . . MGI: J:179821
Edelson BT; Unanue ER. 2002. MyD88-dependent but Toll-like receptor 2-independent innate immunity to Listeria: no role for either in macrophage listericidal activity.. In: . . MGI: J:120406
Eltom S; Belvisi MG; Stevenson CS; Maher SA; Dubuis E; Fitzgerald KA; Birrell MA. 2014. Role of the inflammasome-caspase1/11-IL-1/18 axis in cigarette smoke driven airway inflammation: an insight into the pathogenesis of COPD.. In: . . MGI: J:225298
Ewald SE; Chavarria-Smith J; Boothroyd JC. 2014. NLRP1 is an inflammasome sensor for Toxoplasma gondii.. In: . . MGI: J:206165
Feliciani C; Toto P; Amerio P; Pour SM; Coscione G; Shivji G; Wang B; Sauder DN. 2000. In vitro and in vivo expression of interleukin-1alpha and tumor necrosis factor-alpha mRNA in pemphigus vulgaris: interleukin-1alpha and tumor necrosis factor-alpha are involved in acantholysis.. In: . . MGI: J:127060
Freigang S; Ampenberger F; Spohn G; Heer S; Shamshiev AT; Kisielow J; Hersberger M; Yamamoto M; Bachmann MF; Kopf M. 2011. Nrf2 is essential for cholesterol crystal-induced inflammasome activation and exacerbation of atherosclerosis.. In: . . MGI: J:177309
Freigang S; Ampenberger F; Weiss A; Kanneganti TD; Iwakura Y; Hersberger M; Kopf M. 2013. Fatty acid-induced mitochondrial uncoupling elicits inflammasome-independent IL-1alpha and sterile vascular inflammation in atherosclerosis.. In: . . MGI: J:208219
Gehrig A; Janssen A; Horling F; Grimm C; Weber BH. 2006. The role of caspases in photoreceptor cell death of the retinoschisin-deficient mouse.. In: . . MGI: J:112879
Gross O; Poeck H; Bscheider M; Dostert C; Hannesschlager N; Endres S; Hartmann G; Tardivel A; Schweighoffer E; Tybulewicz V; Mocsai A; Tschopp J; Ruland J. 2009. Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence.. In: . . MGI: J:148538
Gurung P; Karki R; Vogel P; Watanabe M; Bix M; Lamkanfi M; Kanneganti TD. 2015. An NLRP3 inflammasome-triggered Th2-biased adaptive immune response promotes leishmaniasis.. In: . . MGI: J:220540
Hagar JA; Powell DA; Aachoui Y; Ernst RK; Miao EA. 2013. Cytoplasmic LPS activates caspase-11: implications in TLR4-independent endotoxic shock.. In: . . MGI: J:201144
Hanamsagar R; Aldrich A; Kielian T. 2014. Critical role for the AIM2 inflammasome during acute CNS bacterial infection.. In: . . MGI: J:208779
Hanley PJ; Kronlage M; Kirschning C; del Rey A; Di Virgilio F; Leipziger J; Chessell IP; Sargin S; Filippov MA; Lindemann O; Mohr S; Konigs V; Schillers H; Bahler M; Schwab A. 2012. Transient P2X7 receptor activation triggers macrophage death independent of Toll-like receptors 2 and 4, caspase-1, and pannexin-1 proteins.. In: . . MGI: J:183298
Heneka MT; Kummer MP; Stutz A; Delekate A; Schwartz S; Vieira-Saecker A; Griep A; Axt D; Remus A; Tzeng TC; Gelpi E; Halle A; Korte M; Latz E; Golenbock DT. 2013. NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice.. In: . . MGI: J:194405
Henry T; Brotcke A; Weiss DS; Thompson LJ; Monack DM. 2007. Type I interferon signaling is required for activation of the inflammasome during Francisella infection.. In: . . MGI: J:125737
Jamilloux Y; Pierini R; Querenet M; Juruj C; Fauchais AL; Jauberteau MO; Jarraud S; Lina G; Etienne J; Roy CR; Henry T; Davoust N; Ader F. 2013. Inflammasome activation restricts Legionella pneumophila replication in primary microglial cells through flagellin detection.. In: . . MGI: J:193477
Jayaraman P; Sada-Ovalle I; Beladi S; Anderson AC; Dardalhon V; Hotta C; Kuchroo VK; Behar SM. 2010. Tim3 binding to galectin-9 stimulates antimicrobial immunity.. In: . . MGI: J:166066
Jehl SP; Doling AM; Giddings KS; Phalipon A; Sansonetti PJ; Goldberg MB; Starnbach MN. 2011. Antigen-Specific CD8+ T Cells Fail To Respond to Shigella flexneri.. In: . . MGI: J:171947
Jolicoeur P; Hu C; Mak TW; Martinou JC; Kay DG. 2003. Protection against murine leukemia virus-induced spongiform myeloencephalopathy in mice overexpressing Bcl-2 but not in mice deficient for interleukin-6, inducible nitric oxide synthetase, ICE, Fas, Fas ligand, or TNF-R1 genes.. In: . . MGI: J:86761
Kang TJ; Basu S; Zhang L; Thomas KE; Vogel SN; Baillie L; Cross AS. 2008. Bacillus anthracis spores and lethal toxin induce IL-1beta via functionally distinct signaling pathways.. In: . . MGI: J:136368
Katsnelson MA; Lozada-Soto KM; Russo HM; Miller BA; Dubyak GR. 2016. NLRP3 inflammasome signaling is activated by low-level lysosome disruption but inhibited by extensive lysosome disruption: roles for K+ efflux and Ca2+ influx.. In: . . MGI: J:235671
Kayagaki N; Warming S; Lamkanfi M; Vande Walle L; Louie S; Dong J; Newton K; Qu Y; Liu J; Heldens S; Zhang J; Lee WP; Roose-Girma M; Dixit VM. 2011. Non-canonical inflammasome activation targets caspase-11.. In: . . MGI: J:193522
Kayagaki N; Wong MT; Stowe IB; Ramani SR; Gonzalez LC; Akashi-Takamura S; Miyake K; Zhang J; Lee WP; Muszynski A; Forsberg LS; Carlson RW; Dixit VM. 2013. Noncanonical inflammasome activation by intracellular LPS independent of TLR4.. In: . . MGI: J:201075
Kim ML; Chae JJ; Park YH; De Nardo D; Stirzaker RA; Ko HJ; Tye H; Cengia L; DiRago L; Metcalf D; Roberts AW; Kastner DL; Lew AM; Lyras D; Kile BT; Croker BA; Masters SL. 2015. Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1beta.. In: . . MGI: J:224778
Kistowska M; Gehrke S; Jankovic D; Kerl K; Fettelschoss A; Feldmeyer L; Fenini G; Kolios A; Navarini A; Ganceviciene R; Schauber J; Contassot E; French LE. 2014. IL-1beta Drives Inflammatory Responses to Propionibacterium acnes In Vitro and In Vivo.. In: . . MGI: J:206191
Kohli S; Ranjan S; Hoffmann J; Kashif M; Daniel EA; Al-Dabet MM; Bock F; Nazir S; Huebner H; Mertens PR; Fischer KD; Zenclussen AC; Offermanns S; Aharon A; Brenner B; Shahzad K; Ruebner M; Isermann B. 2016. Maternal extracellular vesicles and platelets promote preeclampsia via inflammasome activation in trophoblasts.. In: . . MGI: J:237268
Kordes M; Matuschewski K; Hafalla JC. 2011. Caspase-1 Activation of Interleukin-1{beta} (IL-1{beta}) and IL-18 Is Dispensable for Induction of Experimental Cerebral Malaria.. In: . . MGI: J:175707
Leibundgut-Landmann S; Weidner K; Hilbi H; Oxenius A. 2011. Nonhematopoietic cells are key players in innate control of bacterial airway infection.. In: . . MGI: J:169394
Li P; Allen H; Banerjee S; Franklin S; Herzog L; Johnston C; McDowell J; Paskind M; Rodman L; Salfeld J; Towne E; Tracey D; Wardwell S; Wei FY; Wong W; Kamen R; Seshadri T. 1995. Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock.. In: . . MGI: J:22964
Li P; Allen H; Banerjee S; Seshadri T. 1997. Characterization of mice deficient in interleukin-1 beta converting enzyme.. In: . . MGI: J:40691
Lichtnekert J; Kulkarni OP; Mulay SR; Rupanagudi KV; Ryu M; Allam R; Vielhauer V; Muruve D; Lindenmeyer MT; Cohen CD; Anders HJ. 2011. Anti-GBM Glomerulonephritis Involves IL-1 but Is Independent of NLRP3/ASC Inflammasome-Mediated Activation of Caspase-1.. In: . . MGI: J:178074
Liege S; Moze E; Kelley KW; Parnet P; Neveu PJ. 2000. Activation of the hypothalamic-pituitary-adrenal axis in IL-1 beta-converting enzyme-deficient mice.. In: . . MGI: J:62433
Lightfield KL; Persson J; Brubaker SW; Witte CE; von Moltke J; Dunipace EA; Henry T; Sun YH; Cado D; Dietrich WF; Monack DM; Tsolis RM; Vance RE. 2008. Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin.. In: . . MGI: J:141008
Liu XH; Kwon D; Schielke GP; Yang GY; Silverstein FS; Barks JD. 1999. Mice deficient in interleukin-1 converting enzyme are resistant to neonatal hypoxic-ischemic brain damage.. In: . . MGI: J:98866
MacDuff DA; Reese TA; Kimmey JM; Weiss LA; Song C; Zhang X; Kambal A; Duan E; Carrero JA; Boisson B; Laplantine E; Israel A; Picard C; Colonna M; Edelson BT; Sibley LD; Stallings CL; Casanova JL; Iwai K; Virgin HW. 2015. Phenotypic complementation of genetic immunodeficiency by chronic herpesvirus infection.. In: . . MGI: J:219574
Man SM; Ekpenyong A; Tourlomousis P; Achouri S; Cammarota E; Hughes K; Rizzo A; Ng G; Wright JA; Cicuta P; Guck JR; Bryant CE. 2014. Actin polymerization as a key innate immune effector mechanism to control Salmonella infection.. In: . . MGI: J:216797
Mankan AK; Canli O; Schwitalla S; Ziegler P; Tschopp J; Korn T; Greten FR. 2011. TNF-{alpha}-dependent loss of IKK{beta}-deficient myeloid progenitors triggers a cytokine loop culminating in granulocytosis.. In: . . MGI: J:171365
Mariathasan S; Weiss DS; Dixit VM; Monack DM. 2005. Innate immunity against Francisella tularensis is dependent on the ASC/caspase-1 axis.. In: . . MGI: J:116821
Masters SL; Gerlic M; Metcalf D; Preston S; Pellegrini M; O'Donnell JA; McArthur K; Baldwin TM; Chevrier S; Nowell CJ; Cengia LH; Henley KJ; Collinge JE; Kastner DL; Feigenbaum L; Hilton DJ; Alexander WS; Kile BT; Croker BA. 2012. NLRP1 Inflammasome Activation Induces Pyroptosis of Hematopoietic Progenitor Cells.. In: . . MGI: J:191055
Mastronardi C; Whelan F; Yildiz OA; Hannestad J; Elashoff D; McCann SM; Licinio J; Wong ML. 2007. Caspase 1 deficiency reduces inflammation-induced brain transcription.. In: . . MGI: J:120877
Meissner F; Molawi K; Zychlinsky A. 2008. Superoxide dismutase 1 regulates caspase-1 and endotoxic shock.. In: . . MGI: J:137865
Meunier E; Dick MS; Dreier RF; Schurmann N; Kenzelmann Broz D; Warming S; Roose-Girma M; Bumann D; Kayagaki N; Takeda K; Yamamoto M; Broz P. 2014. Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases.. In: . . MGI: J:210626
Miggin SM; Palsson-McDermott E; Dunne A; Jefferies C; Pinteaux E; Banahan K; Murphy C; Moynagh P; Yamamoto M; Akira S; Rothwell N; Golenbock D; Fitzgerald KA; O'Neill LA. 2007. NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1.. In: . . MGI: J:125936
Milora KA; Fu H; Dubaz O; Jensen LE. 2015. Unprocessed Interleukin-36alpha Regulates Psoriasis-Like Skin Inflammation in Cooperation With Interleukin-1.. In: . . MGI: J:227570
Miwa K; Asano M; Horai R; Iwakura Y; Nagata S; Suda T. 1998. Caspase 1-independent IL-1beta release and inflammation induced by the apoptosis inducer Fas ligand.. In: . . MGI: J:50775
Moayeri M; Crown D; Newman ZL; Okugawa S; Eckhaus M; Cataisson C; Liu S; Sastalla I; Leppla SH. 2010. Inflammasome sensor Nlrp1b-dependent resistance to anthrax is mediated by caspase-1, IL-1 signaling and neutrophil recruitment.. In: . . MGI: J:168096
Mohammadi N; Midiri A; Mancuso G; Patane F; Venza M; Venza I; Passantino A; Galbo R; Teti G; Beninati C; Biondo C. 2016. Neutrophils Directly Recognize Group B Streptococci and Contribute to Interleukin-1beta Production during Infection.. In: . . MGI: J:236919
Monack DM; Hersh D; Ghori N; Bouley D; Zychlinsky A; Falkow S. 2000. Salmonella exploits caspase-1 to colonize Peyer's patches in a murine typhoid model.. In: . . MGI: J:63488
Moreth K; Brodbeck R; Babelova A; Gretz N; Spieker T; Zeng-Brouwers J; Pfeilschifter J; Young MF; Schaefer RM; Schaefer L. 2010. The proteoglycan biglycan regulates expression of the B cell chemoattractant CXCL13 and aggravates murine lupus nephritis.. In: . . MGI: J:171866
Murphey ED. 2011. Cecal ligation and puncture-induced impairment of innate immune function does not occur in the absence of caspase-1.. In: . . MGI: J:178035
Nastase MV; Zeng-Brouwers J; Frey H; Hsieh LT; Poluzzi C; Beckmann J; Schroeder N; Pfeilschifter J; Lopez-Mosqueda J; Mersmann J; Ikeda F; Iozzo RV; Dikic I; Schaefer L. 2016. An Essential Role for SHARPIN in the Regulation of Caspase 1 Activity in Sepsis.. In: . . MGI: J:231908
Pilla DM; Hagar JA; Haldar AK; Mason AK; Degrandi D; Pfeffer K; Ernst RK; Yamamoto M; Miao EA; Coers J. 2014. Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS.. In: . . MGI: J:208845
Priceputu E; Rodrigue I; Chrobak P; Poudrier J; Mak TW; Hanna Z; Hu C; Kay DG; Jolicoeur P. 2005. The Nef-mediated AIDS-like disease of CD4C/human immunodeficiency virus transgenic mice is associated with increased Fas/FasL expression on T cells and T-cell death but is not prevented in Fas-, FasL-, tumor necrosis factor receptor 1-, or interleukin-1beta-converting enzyme-deficient or Bcl2-expressing transgenic mice.. In: . . MGI: J:98353
Qu Y; Misaghi S; Newton K; Maltzman A; Izrael-Tomasevic A; Arnott D; Dixit VM. 2016. NLRP3 recruitment by NLRC4 during Salmonella infection.. In: . . MGI: J:234785
Raupach B; Peuschel SK; Monack DM; Zychlinsky A. 2006. Caspase-1-mediated activation of interleukin-1beta (IL-1beta) and IL-18 contributes to innate immune defenses against Salmonella enterica serovar Typhimurium infection.. In: . . MGI: J:112400
Rosenzweig HL; Galster KT; Planck SR; Rosenbaum JT. 2009. NOD1 expression in the eye and functional contribution to IL-1beta-dependent ocular inflammation in mice.. In: . . MGI: J:146667
Rosenzweig HL; Martin TM; Planck SR; Galster K; Jann MM; Davey MP; Kobayashi K; Flavell RA; Rosenbaum JT. 2008. Activation of NOD2 in vivo induces IL-1beta production in the eye via caspase-1 but results in ocular inflammation independently of IL-1 signaling.. In: . . MGI: J:138433
Rowe SJ; Allen L; Ridger VC; Hellewell PG; Whyte MK. 2002. Caspase-1-deficient mice have delayed neutrophil apoptosis and a prolonged inflammatory response to lipopolysaccharide-induced acute lung injury.. In: . . MGI: J:80568
Ruhl S; Broz P. 2015. Caspase-11 activates a canonical NLRP3 inflammasome by promoting K(+) efflux.. In: . . MGI: J:233045
Samardzija M; Wenzel A; Thiersch M; Frigg R; Reme C; Grimm C. 2006. Caspase-1 ablation protects photoreceptors in a model of autosomal dominant retinitis pigmentosa.. In: . . MGI: J:123100
Sauer JD; Pereyre S; Archer KA; Burke TP; Hanson B; Lauer P; Portnoy DA. 2011. Listeria monocytogenes engineered to activate the Nlrc4 inflammasome are severely attenuated and are poor inducers of protective immunity.. In: . . MGI: J:174533
Schieber AM; Lee YM; Chang MW; Leblanc M; Collins B; Downes M; Evans RM; Ayres JS. 2015. Disease tolerance mediated by microbiome E. coli involves inflammasome and IGF-1 signaling.. In: . . MGI: J:226609
Schielke GP; Yang GY; Shivers BD; Betz AL. 1998. Reduced ischemic brain injury in interleukin-1 beta converting enzyme-deficient mice.. In: . . MGI: J:46306
Schott WH; Haskell BD; Tse HM; Milton MJ; Piganelli JD; Choisy-Rossi CM; Reifsnyder PC; Chervonsky AV; Leiter EH. 2004. Caspase-1 Is Not Required for Type 1 Diabetes in the NOD Mouse.. In: . . MGI: J:87250
Serbina NV; Hohl TM; Cherny M; Pamer EG. 2009. Selective expansion of the monocytic lineage directed by bacterial infection.. In: . . MGI: J:151581
Shi J; Zhao Y; Wang K; Shi X; Wang Y; Huang H; Zhuang Y; Cai T; Wang F; Shao F. 2015. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death.. In: . . MGI: J:226781
Sundquist M; Wick MJ. 2005. TNF-alpha-dependent and -independent maturation of dendritic cells and recruited CD11c(int)CD11b+ Cells during oral Salmonella infection.. In: . . MGI: J:113214
Tang H; Cao W; Kasturi SP; Ravindran R; Nakaya HI; Kundu K; Murthy N; Kepler TB; Malissen B; Pulendran B. 2010. The T helper type 2 response to cysteine proteases requires dendritic cell-basophil cooperation via ROS-mediated signaling.. In: . . MGI: J:161857
Tonti E; Jimenez de Oya N; Galliverti G; Moseman EA; Di Lucia P; Amabile A; Sammicheli S; De Giovanni M; Sironi L; Chevrier N; Sitia G; Gennari L; Guidotti LG; von Andrian UH; Iannacone M. 2013. Bisphosphonates target B cells to enhance humoral immune responses.. In: . . MGI: J:203773
Trunk G; Oxenius A. 2012. Innate instruction of CD4+ T cell immunity in respiratory bacterial infection.. In: . . MGI: J:189793
Vande Walle L; Van Opdenbosch N; Jacques P; Fossoul A; Verheugen E; Vogel P; Beyaert R; Elewaut D; Kanneganti TD; van Loo G; Lamkanfi M. 2014. Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis.. In: . . MGI: J:217119
Vladimer GI; Weng D; Paquette SW; Vanaja SK; Rathinam VA; Aune MH; Conlon JE; Burbage JJ; Proulx MK; Liu Q; Reed G; Mecsas JC; Iwakura Y; Bertin J; Goguen JD; Fitzgerald KA; Lien E. 2012. The NLRP12 inflammasome recognizes Yersinia pestis.. In: . . MGI: J:187388
Wali JA; Gurzov EN; Fynch S; Elkerbout L; Kay TW; Masters SL; Thomas HE. 2014. Activation of the NLRP3 inflammasome complex is not required for stress-induced death of pancreatic islets.. In: . . MGI: J:225299
Wickstrum JR; Bokhari SM; Fischer JL; Pinson DM; Yeh HW; Horvat RT; Parmely MJ. 2009. Francisella tularensis induces extensive caspase-3 activation and apoptotic cell death in the tissues of infected mice.. In: . . MGI: J:154196
Wong ML; Xie B; Beatini N; Phu P; Marathe S; Johns A; Gold PW; Hirsch E; Williams KJ; Licinio J; Tabas I. 2000. Acute systemic inflammation up-regulates secretory sphingomyelinase in vivo: A possible link between inflammatory cytokines and atherogenesis. In: . . MGI: J:63405
Xu H; Barks JD; Schielke GP; Silverstein FS. 2001. Attenuation of hypoxia-ischemia-induced monocyte chemoattractant protein-1 expression in brain of neonatal mice deficient in interleukin-1 converting enzyme.. In: . . MGI: J:69589
Yang GY; Schielke GP; Gong C; Mao Y; Ge HL; Liu XH; Betz AL. 1999. Expression of tumor necrosis factor-alpha and intercellular adhesion molecule-1 after focal cerebral ischemia in interleukin-1beta converting enzyme deficient mice.. In: . . MGI: J:59704
Yao JH; Ye SM; Burgess W; Zachary JF; Kelley KW; Johnson RW. 1999. Mice deficient in interleukin-1beta converting enzyme resist anorexia induced by central lipopolysaccharide.. In: . . MGI: J:58677
Zhang WH; Wang X; Narayanan M; Zhang Y; Huo C; Reed JC; Friedlander RM. 2003. Fundamental role of the Rip2/caspase-1 pathway in hypoxia and ischemia-induced neuronal cell death.. In: . . MGI: J:88212
Zhao Y; Yang J; Shi J; Gong YN; Lu Q; Xu H; Liu L; Shao F. 2011. The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus.. In: . . MGI: J:177040
Zoccal KF; Sorgi CA; Hori JI; Paula-Silva FW; Arantes EC; Serezani CH; Zamboni DS; Faccioli LH. 2016. Opposing roles of LTB4 and PGE2 in regulating the inflammasome-dependent scorpion venom-induced mortality.. In: . . MGI: J:234731
de Bilbao F; Giannakopoulos P; Srinivasan A; Dubois-Dauphin M. 2000. In vivo study of motoneuron death induced by nerve injury in mice deficient in the caspase 1/ interleukin-1 beta-converting enzyme.. In: . . MGI: J:118715
van der Velden AW; Velasquez M; Starnbach MN. 2003. Salmonella rapidly kill dendritic cells via a caspase-1-dependent mechanism.. In: . . MGI: J:118499

Additional - Casp4^del related

Aachoui Y; Leaf IA; Hagar JA; Fontana MF; Campos CG; Zak DE; Tan MH; Cotter PA; Vance RE; Aderem A; Miao EA. 2013. Caspase-11 protects against bacteria that escape the vacuole.. In: . . MGI: J:193387
Desbien AL; Reed SJ; Bailor HR; Dubois Cauwelaert N; Laurance JD; Orr MT; Fox CB; Carter D; Reed SG; Duthie MS. 2015. Squalene emulsion potentiates the adjuvant activity of the TLR4 agonist, GLA, via inflammatory caspases, IL-18, and IFN-gamma.. In: . . MGI: J:222315
Gurung P; Karki R; Vogel P; Watanabe M; Bix M; Lamkanfi M; Kanneganti TD. 2015. An NLRP3 inflammasome-triggered Th2-biased adaptive immune response promotes leishmaniasis.. In: . . MGI: J:220540
Kayagaki N; Stowe IB; Lee BL; O'Rourke K; Anderson K; Warming S; Cuellar T; Haley B; Roose-Girma M; Phung QT; Liu PS; Lill JR; Li H; Wu J; Kummerfeld S; Zhang J; Lee WP; Snipas SJ; Salvesen GS; Morris LX; Fitzgerald L; Zhang Y; Bertram EM; Goodnow CC; Dixit VM. 2015. Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling.. In: . . MGI: J:226780
Kayagaki N; Warming S; Lamkanfi M; Vande Walle L; Louie S; Dong J; Newton K; Qu Y; Liu J; Heldens S; Zhang J; Lee WP; Roose-Girma M; Dixit VM. 2011. Non-canonical inflammasome activation targets caspase-11.. In: . . MGI: J:193522
MacDuff DA; Reese TA; Kimmey JM; Weiss LA; Song C; Zhang X; Kambal A; Duan E; Carrero JA; Boisson B; Laplantine E; Israel A; Picard C; Colonna M; Edelson BT; Sibley LD; Stallings CL; Casanova JL; Iwai K; Virgin HW. 2015. Phenotypic complementation of genetic immunodeficiency by chronic herpesvirus infection.. In: . . MGI: J:219574
Masters SL; Gerlic M; Metcalf D; Preston S; Pellegrini M; O'Donnell JA; McArthur K; Baldwin TM; Chevrier S; Nowell CJ; Cengia LH; Henley KJ; Collinge JE; Kastner DL; Feigenbaum L; Hilton DJ; Alexander WS; Kile BT; Croker BA. 2012. NLRP1 Inflammasome Activation Induces Pyroptosis of Hematopoietic Progenitor Cells.. In: . . MGI: J:191055
Milora KA; Fu H; Dubaz O; Jensen LE. 2015. Unprocessed Interleukin-36alpha Regulates Psoriasis-Like Skin Inflammation in Cooperation With Interleukin-1.. In: . . MGI: J:227570
Place DE; Muse SJ; Kirimanjeswara GS; Harvill ET. 2014. Caspase-1-independent interleukin-1beta is required for clearance of Bordetella pertussis infections and whole-cell vaccine-mediated immunity.. In: . . MGI: J:221522
Shi J; Zhao Y; Wang K; Shi X; Wang Y; Huang H; Zhuang Y; Cai T; Wang F; Shao F. 2015. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death.. In: . . MGI: J:226781
Wynosky-Dolfi MA; Snyder AG; Philip NH; Doonan PJ; Poffenberger MC; Avizonis D; Zwack EE; Riblett AM; Hu B; Strowig T; Flavell RA; Jones RG; Freedman BD; Brodsky IE. 2014. Oxidative metabolism enables Salmonella evasion of the NLRP3 inflammasome.. In: . . MGI: J:211688
Zanoni I; Tan Y; Di Gioia M; Broggi A; Ruan J; Shi J; Donado CA; Shao F; Wu H; Springstead JR; Kagan JC. 2016. An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells.. In: . . MGI: J:232572

Additional - Il10^tm1Cgn related

Aggarwal NR; Tsushima K; Eto Y; Tripathi A; Mandke P; Mock JR; Garibaldi BT; Singer BD; Sidhaye VK; Horton MR; King LS; D'Alessio FR. 2014. Immunological priming requires regulatory T cells and IL-10-producing macrophages to accelerate resolution from severe lung inflammation.. In: . . MGI: J:209966
Akane K; Kojima S; Mak TW; Shiku H; Suzuki H. 2016. CD8+CD122+CD49dlow regulatory T cells maintain T-cell homeostasis by killing activated T cells via Fas/FasL-mediated cytotoxicity.. In: . . MGI: J:230413
Akhiani AA; Stensson A; Schon K; Lycke NY. 2005. IgA antibodies impair resistance against Helicobacter pylori infection: studies on immune evasion in IL-10-deficient mice.. In: . . MGI: J:100891
Alayan J; Ivanovski S; Farah CS. 2007. Alveolar bone loss in T helper 1/T helper 2 cytokine-deficient mice.. In: . . MGI: J:147935
Albert E; Walker J; Thiesen A; Churchill T; Madsen K. 2010. cis-Urocanic acid attenuates acute dextran sodium sulphate-induced intestinal inflammation.. In: . . MGI: J:166665
Aliberti J; Viola JP; Vieira-de-Abreu A; Bozza PT; Sher A; Scharfstein J. 2003. Cutting edge: Bradykinin induces IL-12 production by dendritic cells: a danger signal that drives Th1 polarization.. In: . . MGI: J:83453
Allen HL; Deepe GS Jr. 2005. Apoptosis modulates protective immunity to the pathogenic fungus Histoplasma capsulatum.. In: . . MGI: J:101533
Allen HL; Deepe GS Jr. 2006. B cells and CD4-CD8- T cells are key regulators of the severity of reactivation histoplasmosis.. In: . . MGI: J:138028
Almeida AR; Legrand N; Papiernik M; Freitas AA. 2002. Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers.. In: . . MGI: J:125748
Amante FH; Stanley AC; Randall LM; Zhou Y; Haque A; McSweeney K; Waters AP; Janse CJ; Good MF; Hill GR; Engwerda CR. 2007. A role for natural regulatory T cells in the pathogenesis of experimental cerebral malaria.. In: . . MGI: J:123927
Ameredes BT; Sethi JM; Liu HL; Choi AM; Calhoun WJ. 2005. Enhanced nitric oxide production associated with airway hyporesponsiveness in the absence of IL-10.. In: . . MGI: J:115459
Ameredes BT; Zamora R; Gibson KF; Billiar TR; Dixon-McCarthy B; Watkins S; Calhoun WJ. 2001. Increased nitric oxide production by airway cells of sensitized and challenged IL-10 knockout mice.. In: . . MGI: J:124461
Ameredes BT; Zamora R; Sethi JM; Liu HL; Kohut LK; Gligonic AL; Choi AM; Calhoun WJ. 2005. Alterations in nitric oxide and cytokine production with airway inflammation in the absence of IL-10.. In: . . MGI: J:100726
Ananieva O; Darragh J; Johansen C; Carr JM; McIlrath J; Park JM; Wingate A; Monk CE; Toth R; Santos SG; Iversen L; Arthur JS. 2008. The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling.. In: . . MGI: J:139576
Anderson AC; Reddy J; Nazareno R; Sobel RA; Nicholson LB; Kuchroo VK. 2004. IL-10 plays an important role in the homeostatic regulation of the autoreactive repertoire in naive mice.. In: . . MGI: J:91913
Anderson CF; Oukka M; Kuchroo VJ; Sacks D. 2007. CD4(+)CD25(-)Foxp3(-) Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis.. In: . . MGI: J:125372
Andou A; Hisamatsu T; Okamoto S; Chinen H; Kamada N; Kobayashi T; Hashimoto M; Okutsu T; Shimbo K; Takeda T; Matsumoto H; Sato A; Ohtsu H; Suzuki M; Hibi T. 2009. Dietary histidine ameliorates murine colitis by inhibition of proinflammatory cytokine production from macrophages.. In: . . MGI: J:145874
Andrade EB; Alves J; Madureira P; Oliveira L; Ribeiro A; Cordeiro-da-Silva A; Correia-Neves M; Trieu-Cuot P; Ferreira P. 2013. TLR2-induced IL-10 production impairs neutrophil recruitment to infected tissues during neonatal bacterial sepsis.. In: . . MGI: J:206234
Andrassy M; Igwe J; Autschbach F; Volz C; Remppis A; Neurath MF; Schleicher E; Humpert PM; Wendt T; Liliensiek B; Morcos M; Schiekofer S; Thiele K; Chen J; Kientsch-Engel R; Schmidt AM; Stremmel W; Stern DM; Katus HA; Nawroth PP; Bierhaus A. 2006. Posttranslationally modified proteins as mediators of sustained intestinal inflammation.. In: . . MGI: J:113376
Ankathatti Munegowda M; Xu S; Freywald A; Xiang J. 2012. CD4+ Th2 cells function alike effector Tr1 and Th1 cells through the deletion of a single cytokine IL-6 and IL-10 gene.. In: . . MGI: J:184874
Apte RS; Richter J; Herndon J; Ferguson TA. 2006. Macrophages inhibit neovascularization in a murine model of age-related macular degeneration.. In: . . MGI: J:134144
Arrieta MC; Madsen K; Doyle J; Meddings J. 2009. Reducing small intestinal permeability attenuates colitis in the IL10 gene-deficient mouse.. In: . . MGI: J:213262
Arsenescu R; Blum AM; Metwali A; Elliott DE; Weinstock JV. 2005. IL-12 induction of mRNA encoding substance P in murine macrophages from the spleen and sites of inflammation.. In: . . MGI: J:110005
Auerbuch V; Isberg RR. 2007. Growth of Yersinia pseudotuberculosis in Mice Occurs Independently of Toll-Like Receptor 2 Expression and Induction of Interleukin-10.. In: . . MGI: J:122417
Aviszus K; Macleod MK; Kirchenbaum GA; Detanico TO; Heiser RA; St Clair JB; Guo W; Wysocki LJ. 2012. Antigen-specific suppression of humoral immunity by anergic Ars/A1 B cells.. In: . . MGI: J:190617
Awasthi A; Carrier Y; Peron JP; Bettelli E; Kamanaka M; Flavell RA; Kuchroo VK; Oukka M; Weiner HL. 2007. A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells.. In: . . MGI: J:127774
Bai F; Town T; Qian F; Wang P; Kamanaka M; Connolly TM; Gate D; Montgomery RR; Flavell RA; Fikrig E. 2009. IL-10 signaling blockade controls murine West Nile virus infection.. In: . . MGI: J:162907
Balasa B; La Cava A; Van Gunst K; Mocnik L; Balakrishna D; Nguyen N; Tucker L; Sarvetnick N. 2000. A mechanism for IL-10-mediated diabetes in the nonobese diabetic (NOD) mouse: ICAM-1 deficiency blocks accelerated diabetes. In: . . MGI: J:66103
Balasa B; Van Gunst K; Jung N; Katz JD; Sarvetnick N. 2000. IL-10 deficiency does not inhibit insulitis and accelerates cyclophosphamide-induced diabetes in the nonobese diabetic mouse.. In: . . MGI: J:114170
Bamboat ZM; Ocuin LM; Balachandran VP; Obaid H; Plitas G; Dematteo RP. 2010. Conventional DCs reduce liver ischemia/reperfusion injury in mice via IL-10 secretion.. In: . . MGI: J:156672
Bandukwala HS; Clay BS; Tong J; Mody PD; Cannon JL; Shilling RA; Verbeek JS; Weinstock JV; Solway J; Sperling AI. 2007. Signaling through Fc gamma RIII is required for optimal T helper type (Th)2 responses and Th2-mediated airway inflammation.. In: . . MGI: J:125951
Barbi J; Brombacher F; Satoskar AR. 2008. T Cells from Leishmania major-susceptible BALB/c mice have a defect in efficiently up-regulating CXCR3 upon activation.. In: . . MGI: J:141294
Bassaganya-Riera J; Viladomiu M; Pedragosa M; De Simone C; Hontecillas R. 2012. Immunoregulatory mechanisms underlying prevention of colitis-associated colorectal cancer by probiotic bacteria.. In: . . MGI: J:187088
Beatty PL; Plevy SE; Sepulveda AR; Finn OJ. 2007. Cutting edge: transgenic expression of human MUC1 in IL-10-/- mice accelerates inflammatory bowel disease and progression to colon cancer.. In: . . MGI: J:149347
Beckwith J; Cong Y; Sundberg JP; Elson CO; Leiter EH. 2005. Cdcs1, a major colitogenic locus in mice, regulates innate and adaptive immune response to enteric bacterial antigens.. In: . . MGI: J:101721
Beenhouwer DO; Shapiro S; Feldmesser M; Casadevall A; Scharff MD. 2001. Both Th1 and Th2 Cytokines Affect the Ability of Monoclonal Antibodies To Protect Mice against Cryptococcus neoformans.. In: . . MGI: J:71570
Beissert S; Hosoi J; Kuhn R; Rajewsky K; Muller W; Granstein RD. 1996. Impaired immunosuppressive response to ultraviolet radiation in interleukin-10-deficient mice.. In: . . MGI: J:35510
Beiting DP; Bliss SK; Schlafer DH; Roberts VL; Appleton JA. 2004. Interleukin-10 limits local and body cavity inflammation during infection with muscle-stage Trichinella spiralis.. In: . . MGI: J:90250
Belkaid Y; Hoffmann KF; Mendez S; Kamhawi S; Udey MC; Wynn TA; Sacks DL. 2001. The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure.. In: . . MGI: J:118003
Benakis C; Brea D; Caballero S; Faraco G; Moore J; Murphy M; Sita G; Racchumi G; Ling L; Pamer EG; Iadecola C; Anrather J. 2016. Commensal microbiota affects ischemic stroke outcome by regulating intestinal gammadelta T cells.. In: . . MGI: J:234857
Berg DJ; Davidson N; Kuhn R; Muller W; Menon S; Holland G; Thompson-Snipes L; Leach MW; Rennick D. 1996. Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses.. In: . . MGI: J:35020
Berg DJ; Leach MW; Kuhn R; Rajewsky K; Muller W; Davidson NJ; Rennick D. 1995. Interleukin 10 but not interleukin 4 is a natural suppressant of cutaneous inflammatory responses.. In: . . MGI: J:26221
Bernert H; Sekikawa K; Radcliffe RA; Iraqi F; You M; Malkinson AM. 2003. Tnfa and Il-10 deficiencies have contrasting effects on lung tumor susceptibility: Gender-dependent modulation of IL-10 haploinsufficiency.. In: . . MGI: J:86489
Bettelli E; Das MP; Howard ED; Weiner HL; Sobel RA; Kuchroo VK. 1998. IL-10 is critical in the regulation of autoimmune encephalomyelitis as demonstrated by studies of IL-10- and IL-4-deficient and transgenic mice.. In: . . MGI: J:115204
Bettenworth D; Buyse M; Bohm M; Mennigen R; Czorniak I; Kannengiesser K; Brzoska T; Luger TA; Kucharzik T; Domschke W; Maaser C; Lugering A. 2011. The tripeptide KdPT protects from intestinal inflammation and maintains intestinal barrier function.. In: . . MGI: J:176323
Bhattacharyya S; Deb J; Patra AK; Thuy Pham DA; Chen W; Vaeth M; Berberich-Siebelt F; Klein-Hessling S; Lamperti ED; Reifenberg K; Jellusova J; Schweizer A; Nitschke L; Leich E; Rosenwald A; Brunner C; Engelmann S; Bommhardt U; Avots A; Muller MR; Kondo E; Serfling E. 2011. NFATc1 affects mouse splenic B cell function by controlling the calcineurin--NFAT signaling network.. In: . . MGI: J:177319
Biburger M; Tiegs G. 2008. Activation-induced NKT cell hyporesponsiveness protects from alpha-galactosylceramide hepatitis and is independent of active transregulatory factors.. In: . . MGI: J:137749
Biswas A; Wilmanski J; Forsman H; Hrncir T; Hao L; Tlaskalova-Hogenova H; Kobayashi KS. 2011. Negative regulation of Toll-like receptor signaling plays an essential role in homeostasis of the intestine.. In: . . MGI: J:174655
Bleich A; Buchler G; Beckwith J; Petell LM; Affourtit JP; King BL; Shaffer DJ; Roopenian DC; Hedrich HJ; Sundberg JP; Leiter EH. 2010. Cdcs1 a major colitis susceptibility locus in mice; subcongenic analysis reveals genetic complexity.. In: . . MGI: J:171733
Bleich A; Janus LM; Smoczek A; Westendorf AM; Strauch U; Mahler M; Hedrich HJ; Fichtner-Feigl S; Scholmerich J; Falk W; Hofmann C; Obermeier F. 2009. CpG motifs of bacterial DNA exert protective effects in mouse models of IBD by antigen-independent tolerance induction.. In: . . MGI: J:145618
Bliss SK; Alcaraz A; Appleton JA. 2003. IL-10 prevents liver necrosis during murine infection with Trichinella spiralis.. In: . . MGI: J:85372
Bliss SK; Bliss SP; Beiting DP; Alcaraz A; Appleton JA. 2007. IL-10 regulates movement of intestinally derived CD4+ T cells to the liver.. In: . . MGI: J:148582
Blois SM; Ilarregui JM; Tometten M; Garcia M; Orsal AS; Cordo-Russo R; Toscano MA; Bianco GA; Kobelt P; Handjiski B; Tirado I; Markert UR; Klapp BF; Poirier F; Szekeres-Bartho J; Rabinovich GA; Arck PC. 2007. A pivotal role for galectin-1 in fetomaternal tolerance.. In: . . MGI: J:130208
Blum A; Setiawan T; Hang L; Stoyanoff K; Weinstock JV. 2008. Interleukin-12 (IL-12) and IL-23 induction of substance p synthesis in murine T cells and macrophages is subject to IL-10 and transforming growth factor beta regulation.. In: . . MGI: J:139373
Bollyky PL; Falk BA; Long SA; Preisinger A; Braun KR; Wu RP; Evanko SP; Buckner JH; Wight TN; Nepom GT. 2009. CD44 costimulation promotes FoxP3+ regulatory T cell persistence and function via production of IL-2, IL-10, and TGF-beta.. In: . . MGI: J:151479
Bollyky PL; Wu RP; Falk BA; Lord JD; Long SA; Preisinger A; Teng B; Holt GE; Standifer NE; Braun KR; Xie CF; Samuels PL; Vernon RB; Gebe JA; Wight TN; Nepom GT. 2011. ECM components guide IL-10 producing regulatory T-cell (TR1) induction from effector memory T-cell precursors.. In: . . MGI: J:172198
Bosmann M; Haggadone MD; Zetoune FS; Sarma JV; Ward PA. 2013. The interaction between C5a and both C5aR and C5L2 receptors is required for production of G-CSF during acute inflammation.. In: . . MGI: J:201024
Bosschaerts T; Guilliams M; Noel W; Herin M; Burk RF; Hill KE; Brys L; Raes G; Ghassabeh GH; De Baetselier P; Beschin A. 2008. Alternatively activated myeloid cells limit pathogenicity associated with African trypanosomiasis through the IL-10 inducible gene selenoprotein P.. In: . . MGI: J:134536
Bowie RV; Donatello S; Lyes C; Owens MB; Babina IS; Hudson L; Walsh SV; O'Donoghue DP; Amu S; Barry SP; Fallon PG; Hopkins AM. 2012. Lipid rafts are disrupted in mildly inflamed intestinal microenvironments without overt disruption of the epithelial barrier.. In: . . MGI: J:185388
Brewer S; McPherson M; Fujiwara D; Turovskaya O; Ziring D; Chen L; Takedatsu H; Targan SR; Wei B; Braun J. 2008. Molecular imaging of murine intestinal inflammation with 2-deoxy-2-[18F]fluoro-D-glucose and positron emission tomography.. In: . . MGI: J:142005
Bristol IJ; Farmer MA; Cong Y; Zheng XX; Strom TB; Elson CO; Sundberg JP; Leiter EH. 2000. Heritable susceptibility for colitis in mice induced by IL-10 deficiency.. In: . . MGI: J:109882
Brooks DG; Trifilo MJ; Edelmann KH; Teyton L; McGavern DB; Oldstone MB. 2006. Interleukin-10 determines viral clearance or persistence in vivo.. In: . . MGI: J:115332
Brooks DG; Walsh KB; Elsaesser H; Oldstone MB. 2010. IL-10 directly suppresses CD4 but not CD8 T cell effector and memory responses following acute viral infection.. In: . . MGI: J:157557
Browne EP. 2013. Toll-Like Receptor 7 Inhibits Early Acute Retroviral Infection through Rapid Lymphocyte Responses.. In: . . MGI: J:198442
Brunn A; Mihelcic M; Carstov M; Hummel L; Geier F; Schmidt A; Saupe L; Utermohlen O; Deckert M. 2014. IL-10, IL-4, and STAT6 promote an M2 milieu required for termination of P0(106-125)-induced murine experimental autoimmune neuritis.. In: . . MGI: J:214835
Buchheister S; Buettner M; Basic M; Noack A; Breves G; Buchen B; Keubler LM; Becker C; Bleich A. 2017. CD14 Plays a Protective Role in Experimental Inflammatory Bowel Disease by Enhancing Intestinal Barrier Function.. In: . . MGI: J:242238
Bundoc VG; Keane-Myers A. 2007. IL-10 confers protection from mast cell degranulation in a mouse model of allergic conjunctivitis.. In: . . MGI: J:126367
Bunt SK; Clements VK; Hanson EM; Sinha P; Ostrand-Rosenberg S. 2009. Inflammation enhances myeloid-derived suppressor cell cross-talk by signaling through Toll-like receptor 4.. In: . . MGI: J:149766
Burich A; Hershberg R; Waggie K; Zeng W; Brabb T; Westrich G; Viney JL; Maggio-Price L. 2001. Helicobacter-induced inflammatory bowel disease in IL-10- and T cell-deficient mice.. In: . . MGI: J:108283
Buxbaum LU; Scott P. 2005. Interleukin 10- and Fcgamma receptor-deficient mice resolve Leishmania mexicana lesions.. In: . . MGI: J:97206
Cain JA; Smith JA; Ondr JK; Wang B; Katz JD. 2006. NKT cells and IFN-gamma establish the regulatory environment for the control of diabetogenic T cells in the nonobese diabetic mouse.. In: . . MGI: J:126603
Caligiuri G; Rudling M; Ollivier V; Jacob MP; Michel JB; Hansson GK; Nicoletti A. 2003. Interleukin-10 deficiency increases atherosclerosis, thrombosis, and low-density lipoproteins in apolipoprotein E knockout mice.. In: . . MGI: J:105858
Cantorna MT; Munsick C; Bemiss C; Mahon BD. 2000. 1,25-Dihydroxycholecalciferol prevents and ameliorates symptoms of experimental murine inflammatory bowel disease. In: . . MGI: J:65513
Cao AT; Yao S; Stefka AT; Liu Z; Qin H; Liu H; Evans-Marin HL; Elson CO; Nagler CR; Cong Y. 2014. TLR4 regulates IFN-gamma and IL-17 production by both thymic and induced Foxp3+ Tregs during intestinal inflammation.. In: . . MGI: J:220139
Carregaro V; Valenzuela JG; Cunha TM; Verri WA Jr; Grespan R; Matsumura G; Ribeiro JM; Elnaiem DE; Silva JS; Cunha FQ. 2008. Phlebotomine salivas inhibit immune inflammation-induced neutrophil migration via an autocrine DC-derived PGE2/IL-10 sequential pathway.. In: . . MGI: J:137750
Carrero JA; Calderon B; Unanue ER. 2006. Lymphocytes are detrimental during the early innate immune response against Listeria monocytogenes.. In: . . MGI: J:123753
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Xue X; Feng T; Yao S; Wolf KJ; Liu CG; Liu X; Elson CO; Cong Y. 2011. Microbiota downregulates dendritic cell expression of miR-10a, which targets IL-12/IL-23p40.. In: . . MGI: J:179678
Yan F; John SK; Wilson G; Jones DS; Washington MK; Polk DB. 2004. Kinase suppressor of Ras-1 protects intestinal epithelium from cytokine-mediated apoptosis during inflammation.. In: . . MGI: J:94534
Yan X; Hegab AE; Endo J; Anzai A; Matsuhashi T; Katsumata Y; Ito K; Yamamoto T; Betsuyaku T; Shinmura K; Shen W; Vivier E; Fukuda K; Sano M. 2014. Lung natural killer cells play a major counter-regulatory role in pulmonary vascular hyperpermeability after myocardial infarction.. In: . . MGI: J:223700
Yanaba K; Bouaziz JD; Haas KM; Poe JC; Fujimoto M; Tedder TF. 2008. A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses.. In: . . MGI: J:136340
Yanaba K; Bouaziz JD; Matsushita T; Tsubata T; Tedder TF. 2009. The development and function of regulatory B cells expressing IL-10 (B10 cells) requires antigen receptor diversity and TLR signals.. In: . . MGI: J:149301
Yanaba K; Kamata M; Ishiura N; Shibata S; Asano Y; Tada Y; Sugaya M; Kadono T; Tedder TF; Sato S. 2013. Regulatory B cells suppress imiquimod-induced, psoriasis-like skin inflammation.. In: . . MGI: J:202646
Yang F; Dong A; Mueller P; Caicedo J; Sutton AM; Odetunde J; Barrick CJ; Klyachkin YM; Abdel-Latif A; Smyth SS. 2012. Coronary artery remodeling in a model of left ventricular pressure overload is influenced by platelets and inflammatory cells.. In: . . MGI: J:190055
Yang HT; Wang Y; Zhao X; Demissie E; Papoutsopoulou S; Mambole A; O'Garra A; Tomczak MF; Erdman SE; Fox JG; Ley SC; Horwitz BH. 2011. NF-(kappa)B1 inhibits TLR-induced IFN-(beta) production in macrophages through TPL-2-dependent ERK activation.. In: . . MGI: J:169175
Yang I; Eibach D; Kops F; Brenneke B; Woltemate S; Schulze J; Bleich A; Gruber AD; Muthupalani S; Fox JG; Josenhans C; Suerbaum S. 2013. Intestinal microbiota composition of interleukin-10 deficient C57BL/6J mice and susceptibility to Helicobacter hepaticus-induced colitis.. In: . . MGI: J:204929
Yang M; Deng J; Liu Y; Ko KH; Wang X; Jiao Z; Wang S; Hua Z; Sun L; Srivastava G; Lau CS; Cao X; Lu L. 2012. IL-10-Producing Regulatory B10 Cells Ameliorate Collagen-Induced Arthritis via Suppressing Th17 Cell Generation.. In: . . MGI: J:184805
Yang M; Sun L; Wang S; Ko KH; Xu H; Zheng BJ; Cao X; Lu L. 2010. Novel function of B cell-activating factor in the induction of IL-10-producing regulatory B cells.. In: . . MGI: J:160064
Yang X; Wang S; Fan Y; Han X. 2000. IL-10 deficiency prevents IL-5 overproduction and eosinophilic inflammation in a murine model of asthma-like reaction.. In: . . MGI: J:60381
Yang Y; Huycke MM; Herman TS; Wang X. 2016. Glutathione S-transferase alpha 4 induction by activator protein 1 in colorectal cancer.. In: . . MGI: J:237932
Yang Z; Zhang X; Darrah PA; Mosser DM. 2010. The Regulation of Th1 Responses by the p38 MAPK.. In: . . MGI: J:165637
Yao Y; Li W; Kaplan MH; Chang CH. 2005. Interleukin (IL)-4 inhibits IL-10 to promote IL-12 production by dendritic cells.. In: . . MGI: J:99206
Yen D; Cheung J; Scheerens H; Poulet F; McClanahan T; McKenzie B; Kleinschek MA; Owyang A; Mattson J; Blumenschein W; Murphy E; Sathe M; Cua DJ; Kastelein RA; Rennick D. 2006. IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6.. In: . . MGI: J:108946
Yen JH; Kong W; Hooper KM; Emig F; Rahbari KM; Kuo PC; Scofield BA; Ganea D. 2015. Differential effects of IFN-beta on IL-12, IL-23, and IL-10 expression in TLR-stimulated dendritic cells.. In: . . MGI: J:242734
Yin S; Wang H; Park O; Wei W; Shen J; Gao B. 2011. Enhanced Liver Regeneration in IL-10-Deficient Mice after Partial Hepatectomy via Stimulating Inflammatory Response and Activating Hepatocyte STAT3.. In: . . MGI: J:169853
Yin Z; Bahtiyar G; Zhang N; Liu L; Zhu P; Robert ME; McNiff J; Madaio MP; Craft J. 2002. IL-10 regulates murine lupus.. In: . . MGI: J:78239
Yoshizaki A; Miyagaki T; DiLillo DJ; Matsushita T; Horikawa M; Kountikov EI; Spolski R; Poe JC; Leonard WJ; Tedder TF. 2012. Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions.. In: . . MGI: J:189218
Young A; Linehan E; Hams E; O'Hara Hall AC; McClurg A; Johnston JA; Hunter CA; Fallon PG; Fitzgerald DC. 2012. Cutting edge: suppression of GM-CSF expression in murine and human T cells by IL-27.. In: . . MGI: J:189868
Zediak VP; Hunter CA. 2003. IL-10 fails to inhibit the production of IL-18 in response to inflammatory stimuli.. In: . . MGI: J:128186
Zemse SM; Chiao CW; Hilgers RH; Webb RC. 2010. Interleukin-10 inhibits the in vivo and in vitro adverse effects of TNF-{alpha} on the endothelium of murine aorta.. In: . . MGI: J:162772
Zhang B; Maris CH; Foell J; Whitmire J; Niu L; Song J; Kwon BS; Vella AT; Ahmed R; Jacob J; Mittler RS. 2007. Immune suppression or enhancement by CD137 T cell costimulation during acute viral infection is time dependent.. In: . . MGI: J:127406
Zhang H; Stolz DB; Chalasani G; Thomson AW. 2013. Hepatic B cells are readily activated by Toll-like receptor-4 ligation and secrete less interleukin-10 than lymphoid tissue B cells.. In: . . MGI: J:200639
Zhang L; Yuan S; Cheng G; Guo B. 2011. Type I IFN promotes IL-10 production from T cells to suppress Th17 cells and Th17-associated autoimmune inflammation.. In: . . MGI: J:182267
Zhang N; Schroppel B; Lal G; Jakubzick C; Mao X; Chen D; Yin N; Jessberger R; Ochando JC; Ding Y; Bromberg JS. 2009. Regulatory T cells sequentially migrate from inflamed tissues to draining lymph nodes to suppress the alloimmune response.. In: . . MGI: J:147032
Zhang R; Li Q; Chuang PY; Lu G; Liu R; Yang J; Peng L; Dai Y; Zheng Z; Qi CF; He JC; Xiong H. 2013. Regulation of pathogenic th17 cell differentiation by IL-10 in the development of glomerulonephritis.. In: . . MGI: J:198724
Zhang R; Li Y; Beck PL; McCafferty DM. 2007. Toll-like receptor 4 regulates colitis-associated adenocarcinoma development in interleukin-10-deficient (IL-10(-/-)) mice.. In: . . MGI: J:131228
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Also Known As: NOD-IL1-10null/Casp1null

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Casp1tm1Sesh

Allele Symbol: Casp1tm1Sesh

Casp4del

Allele Symbol: Casp4del

Il10tm1Cgn

Allele Symbol: Il10tm1Cgn

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Genotype: Casp1tm1Sesh related

Genotype: Il10tm1Cgn related

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Also Known As: NOD-IL1-10^null/Casp1^null

Casp1^tm1Sesh

Allele Symbol: Casp1^tm1Sesh

Casp4^del

Allele Symbol: Casp4^del

Il10^tm1Cgn

Allele Symbol: Il10^tm1Cgn

Genotype: Casp1^tm1Sesh related

Genotype: Il10^tm1Cgn related

Additional - Casp1^tm1Sesh related

Additional - Casp4^del related

Additional - Il10^tm1Cgn related