These mice carry a spontaneous mutation the confers resistance to splenomegaly induction by Friend leukemia virus (FLV).
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous | Fv4 | Friend virus susceptibility 4 |
An allele providing resistance to Friend murine leukemia virus was identified in several wild mouse populations in Japan, Southeast Asia and western North America (Suzuki et al, 1975, Odaka et al, 1981). The (r) allele dominantly confers resistance to ecotropic murine leukemia virus (MuLV) and Moloney murine sarcoma virus (MuSV). Mice carrying the resistance allele suppress virus growth and do not develop splenomegaly. However, immunodeficient mice homozygous for Hfh11nu and heterozygous for Fvr are susceptible, suggesting an additional immune system requirement for resistance and a recessive mode of inheritance (Higo, et al 1997).
This congenic was developed by backcrossing virus resistant Japanese wild mice Mus musculus molossinus to BALB/c (Odaka, et al 1978 and 1981). Resistant mice were selected by spleen weight (virus-induced splenomegaly) and progeny testing results (Odaka, et al 1981). The virus used was the Friend isolate of murine leukemia virus. Several congenic lines were developed including an N6 congenic line designated C4W (from the wild mouse Fu), and an independently derived N6 congenic line described as Hz (from the wild mouse Hz-IV) (Odaka, et al 1978, Kozak, et al, 1984, Ikeda, et al 1985). The Hz-IV mice were originally tested by crossing to C57L and C57BL/6, it is not clear if the backcross to BALB/c began with these F1 mice or the original Hz-IV mice. Although the history is ambiguous, we believe Dr. Wallace Rowe at the NIAID Laboratory of Viral Disease received mice derived from Hz-IV from Dr. Odaka at the University of Tokyo. Dr. Morse obtained these mice from Dr. Rowe in 1983. The strain has been maintained by brother x sister matings since that time. The backcross generation is unknown, but is greater than N6. This strain was donated to The Jackson Laboratory in 2004.
Allele Name | host resistance (Friend leukemia virus) |
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Allele Type | Spontaneous |
Allele Synonym(s) | Fv-4r; Fv-4wr |
Gene Symbol and Name | Fv4, Friend virus susceptibility 4 |
Gene Synonym(s) | |
Strain of Origin | multiple strains |
Chromosome | 12 |
Molecular Note | This allele, associated with natural resistance to infection by ecotropic Friend murine leukemia virus (FLV, MuLV) and Murine sarcoma virus, was identified in several wild mouse populations in Japan, Southeast Asia and western North America. Sequencing demonstrated that the allele contains ecotropic MuLV-related proviral sequence beginning in the C-terminal end of the pol region and extending through the env region and the 3' long terminal repeat. |
When using the C.Cg-Fv4r/HmJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #005316 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Heterozygous for Fv4<r> |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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